[go: up one dir, main page]

BRPI0516674A - método de análise de mal de alzheimer e reagente de diagnóstico - Google Patents

método de análise de mal de alzheimer e reagente de diagnóstico

Info

Publication number
BRPI0516674A
BRPI0516674A BRPI0516674-8A BRPI0516674A BRPI0516674A BR PI0516674 A BRPI0516674 A BR PI0516674A BR PI0516674 A BRPI0516674 A BR PI0516674A BR PI0516674 A BRPI0516674 A BR PI0516674A
Authority
BR
Brazil
Prior art keywords
alzheimer
amyloid
disease
diagnostic reagent
analysis method
Prior art date
Application number
BRPI0516674-8A
Other languages
English (en)
Inventor
Shigeo Takayama
Yamada Yuji
Original Assignee
Sanko Junyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanko Junyaku Kk filed Critical Sanko Junyaku Kk
Publication of BRPI0516674A publication Critical patent/BRPI0516674A/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
    • G01N33/541—Double or second antibody, i.e. precipitating antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

MéTODO DE ANáLISE DE MAL DE ALZHEIMER E REAGENTE DE DIAGNóSTICO. A presente invenção objetiva inventar um processo de medição de <225>-amilóide em uma amostra biológica tal como sangue e aplicar o processo para diagnosticar mal de Alzheimer. é possível analisar o mal de Alzheimer através da medição da quantidade total de <225>-amilóide 1-42 e de fragmentos de <225>-amilóide 1-42, cada um dos quais retém o sítio C-terminal do <225>-amilóide 1-42 na amostra biológica através de uma análise imunológica na qual um anticorpo que reconhece o sítio C-terminal do <225>-amilóide 1-42 é usado. é preferível que a análise imunológica seja uma análise imunológica competitiva.
BRPI0516674-8A 2004-10-28 2005-10-27 método de análise de mal de alzheimer e reagente de diagnóstico BRPI0516674A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004314639 2004-10-28
JP2005052003 2005-02-25
PCT/JP2005/019787 WO2006046644A1 (ja) 2004-10-28 2005-10-27 アルツハイマー病の検定方法及び診断試薬

Publications (1)

Publication Number Publication Date
BRPI0516674A true BRPI0516674A (pt) 2008-09-16

Family

ID=36227886

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0516674-8A BRPI0516674A (pt) 2004-10-28 2005-10-27 método de análise de mal de alzheimer e reagente de diagnóstico

Country Status (13)

Country Link
US (1) US20080199879A1 (pt)
EP (1) EP1813947A4 (pt)
JP (1) JPWO2006046644A1 (pt)
KR (1) KR20070073778A (pt)
CN (1) CN101048662A (pt)
AU (1) AU2005297854A1 (pt)
BR (1) BRPI0516674A (pt)
CA (1) CA2585148A1 (pt)
IL (1) IL182540A0 (pt)
MX (1) MX2007005053A (pt)
NO (1) NO20072206L (pt)
RU (1) RU2007119535A (pt)
WO (1) WO2006046644A1 (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
PT1976877E (pt) 2005-11-30 2014-04-29 Abbvie Inc Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações
CN117903302A (zh) 2005-11-30 2024-04-19 Abbvie 公司 抗-Aβ球聚体抗体，其相关产品，生产所述抗体的方法，所述抗体的应用以及使用方法
ES2454253T3 (es) 2005-12-12 2014-04-10 Ac Immune S.A. Anticuerpos monoclonales específicos de beta A 1-42 con propiedades terapéuticas
US20090291453A1 (en) * 2006-04-13 2009-11-26 Shigeo Takayama Method for Testing Alzheimer's Disease by Measuring Degradation Rate of B-Amyloid in Blood and Diagnostic Reagent
KR101605207B1 (ko) 2006-07-14 2016-03-22 에이씨 이뮨 에스.에이. 아밀로이드 베타에 대해 인간화된 항체
JP4683298B2 (ja) * 2006-08-21 2011-05-18 アイシン精機株式会社 被検物質の免疫測定方法、及び免疫結合親和性解析の制御方法
US8455626B2 (en) * 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20100311767A1 (en) 2007-02-27 2010-12-09 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
EP2865670B1 (en) 2007-04-18 2017-01-11 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
WO2009016734A1 (ja) * 2007-07-31 2009-02-05 University Of Tsukuba 軽度認知機能障害の検定方法
RU2571859C2 (ru) * 2007-10-05 2015-12-20 Дженентек, Инк. Применение антитела против амилоида-бета при глазных заболеваниях
ES2445590T3 (es) 2007-10-05 2014-03-04 Genentech, Inc. Uso de anticuerpo anti-amiloide beta en enfermedades oculares
EP2224000B1 (en) * 2007-10-29 2020-05-13 TAO Health Life Pharma Co., Ltd. Antibody and use thereof
US20110263450A1 (en) * 2008-09-26 2011-10-27 The University Of Melbourne Alzheimer's disease biomarkers
EP2475428B1 (en) 2009-09-11 2015-07-01 Probiodrug AG Heterocylcic derivatives as inhibitors of glutaminyl cyclase
DK2510359T3 (en) 2009-12-11 2015-12-07 Araclón Biotech S L METHODS AND REAGENTS FOR IMPROVED DETECTION OF AMYLOID-BETA PEPTIDES
CN102713622B (zh) * 2010-01-28 2015-02-11 松下健康医疗器械株式会社 β淀粉样蛋白的测定方法
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
BR112012022478B1 (pt) 2010-03-10 2021-09-21 Probiodrug Ag Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica
CN104744591B (zh) 2010-04-15 2022-09-27 Abbvie德国有限责任两合公司 β淀粉样蛋白结合蛋白
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
EP3533803B1 (en) 2010-08-14 2021-10-27 AbbVie Inc. Anti-amyloid-beta antibodies
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
EP2511296A1 (en) 2011-04-12 2012-10-17 Araclón Biotech, S. L. Antibody, kit and method for determination of amyloid peptides
WO2012142300A2 (en) * 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
US9541561B2 (en) 2012-06-14 2017-01-10 Electronics And Telecommunications Research Institute Method for diagnosing Alzheimer's disease using biomaterial
JP5991666B2 (ja) * 2012-07-04 2016-09-14 公立大学法人大阪市立大学 アルツハイマー病を検出する方法及びキット
JP2016103980A (ja) * 2013-03-08 2016-06-09 パナソニックヘルスケア株式会社 ハイブリドーマ及びモノクローナル抗体
US11360098B2 (en) 2015-09-28 2022-06-14 Quest Diagnostics Investments Llc Amyloid beta detection by mass spectrometry
WO2017141881A1 (ja) * 2016-02-15 2017-08-24 ノーベルファーマ株式会社 遺伝性疾患に関わるタンパク質の測定方法及び測定キット
EP3242134A1 (en) * 2016-05-04 2017-11-08 Euroimmun Medizinische Labordiagnostika AG Assay for the diagnosis of a neurological disease
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase
WO2022197651A1 (en) * 2021-03-16 2022-09-22 Neurovision Imaging, Inc. Biofluid-based methods for diagnosing alzheimer's disease-associated conditions
CN113311153B (zh) * 2021-05-12 2023-05-26 华中科技大学 一种用于阿尔茨海默病诊疗一体化的多功能的纳米粒子

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0411974A1 (en) * 1989-07-05 1991-02-06 N.V. Innogenetics S.A. Monoclonal antibodies to a neurofibrillary tangle antigen
US6610493B1 (en) * 1993-06-17 2003-08-26 Brigham And Women's Hospital Screening compounds for the ability to alter the production of amyloid-β peptide
US5786180A (en) * 1995-02-14 1998-07-28 Bayer Corporation Monoclonal antibody 369.2B specific for β A4 peptide
ATE277952T1 (de) * 2001-06-12 2004-10-15 Wiltfang Jens Monoklonaler antikörper, mbab 1e8, welcher für die zwei ersten n-terminalen aminosäuren von amyloid-beta-peptiden spezifisch ist und dessen verwendung zum nachweis von amyloid-beta peptiden und/oder sappa
CA2457502A1 (en) * 2001-08-10 2003-03-06 Ming-Chih Crouthamel Gamma three protease
JP2005532276A (ja) * 2002-03-05 2005-10-27 ラモト アト テル−アヴィヴ ユニバーシティ リミテッド 免疫化組成物およびアミロイド前駆体タンパク質のβ−セクレターゼ開裂部位に対する免疫応答を誘発する方法

Also Published As

Publication number Publication date
EP1813947A1 (en) 2007-08-01
KR20070073778A (ko) 2007-07-10
AU2005297854A1 (en) 2006-05-04
CA2585148A1 (en) 2006-05-04
JPWO2006046644A1 (ja) 2008-05-22
CN101048662A (zh) 2007-10-03
WO2006046644A1 (ja) 2006-05-04
EP1813947A4 (en) 2008-06-11
IL182540A0 (en) 2007-09-20
NO20072206L (no) 2007-07-30
RU2007119535A (ru) 2008-12-10
US20080199879A1 (en) 2008-08-21
MX2007005053A (es) 2007-06-19

Similar Documents

Publication Publication Date Title
BRPI0516674A (pt) método de análise de mal de alzheimer e reagente de diagnóstico
EP1922325A4 (en) METHODS FOR DIAGNOSING DEMENTIA AND OTHER NEUROLOGICAL DISORDERS
ATE554386T1 (de) Verbesserte immunoassayverfahren
DE602004017201D1 (de) Nachweis einer histonmodifikation in zellfreien nukleosomen
BRPI0613478B8 (pt) dispositivo para análise quantitativa de um perfil de metabólito
BRPI0923199B8 (pt) método para determinar a presença de anticorpos de fixação de complemento
ES2572372T3 (es) Método de diagnóstico de enfermedades neurodegenerativas basado en la medición de los niveles o de la actividad de SIRT1
BRPI0114343B1 (pt) MÉTODO PARA DETECÇÃO DE IMUNOGLOBULINA IgE E PARA DIAGNÓSTICO IN VITRO DE ALERGIAS, BEM COMO CHIP DE MICROARRANJO E KIT QUE O COMPREENDE
ATE452343T1 (de) Verbesserte vitamin-d-messung
BRPI0411059A (pt) tiras de teste diagnóstico para detecção de um analito de interesse em uma amostra lìquida, para detecção de anticorpo de anti-hiv em uma amostra, e de teste de gravidez de imuno-diagnóstico, e, método de detecção de um anticorpo de interesse em uma amostra lìquida
WO2008069975A3 (en) Methods of using f-spondin as a biomarker for cartilage degenerative conditions
BRPI0619748A8 (pt) anticorpo monoclonal, polinucleotídeo, região variável de cadeia leve, região variável de cadeia pesada, composição, mistura, métodos para produzir um anticorpo, para preparar uma composição farmacêutica ou uma mistura, de diagnóstico de uma doença ou condição associada a amilóide, para determinar o grau de carga de placa amiloidogênica em um tecido, para diagnosticar uma predisposição para uma doença ou condição, para monitorar doença residual mínima e para prever responsabilidade de um paciente, uso de um anticorpo monoclonal e/ou uma parte funcional do mesmo e/ou uma composição farmacêutica ou uma mistura, linhagem celular de hibridoma, e, kits de teste
BR112016004320A2 (pt) biossensor, sistema, kit, métodos de determinação ou de identificação e de quantificação de uma concentração de amônia ou íon amônio, de diagnóstico de uma doença metabólica em um sujeito, de determinação da resposta do paciente a uma terapia, de fabricação de um biossensor, de um sistema ou de qualquer tira de teste e de detecção da presença, ausência, ou quantidade de aminoácidos em uma amostra, e, tira de teste
Sanchez et al. Factors influencing the prevalence of Salmonella spp. in swine farms: a meta-analysis approach
EA201400113A1 (ru) Биологический микрочип для количественного определения иммуноглобулинов классов e и g в биологических жидкостях, способ проведения анализа с его использованием и набор реагентов, его включающий
Fuentes-Rubio et al. Measurements of salivary alpha-amylase in horse: comparison of 2 different assays
AR071034A1 (es) Uso de la catepsina c en el diagnostico de susceptibilidad al dolor y para el tratamiento del dolor
BR0313194A (pt) Método para diagnose de esclerose múltipla
BR112018076005A2 (pt) anticorpo monoclonal isolado, método para medir o nível de gama-glutamil-l-epsilon-lisina (ggel), método ex vivo para o monitoramento de apoptose, uso de um anticorpo monoclonal específico para gama-glutamil-l-epsilon-lisina (ggel), métodos para monitorar a eficácia de um tratamento indutor de apoptose, método de tratamento de uma doença associada a apoptose desregulada, kit para o monitoramento de apoptose, método de tratamento de sepse e dispositivo de imunoensaio de fluxo lateral
DE60140346D1 (de) System zur internen, qualitativen und quantitativen überprüfung von zellmarker-indices
MX2010002009A (es) Panel de salud de aparato reproductor masculino y usos del mismo.
EP1898215A4 (en) METHOD FOR ANALYZING ENDOCRINE SUBSTANCE IN A SPECIMEN
Jackson et al. Epidemiology of fracture risk in the Women’s Health Initiative
EP2338988A4 (en) ASSESSMENT / SCREENING METHODS FOR DISEASES ASSOCIATED WITH D-AMINO ACID BY DAO1 - / - MOUSE
BRPI0415562B8 (pt) método in vitro para avaliação prognóstica de carcinoma de ovário em um paciente, e, kit de imunoensaio

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: EISAI RANDD MANAGEMENT CO., LTD. (JP)

Free format text: TRANSFERIDO DE: SANKO JUNYAKU CO., LTD.

B10A Cessation: cessation confirmed

Free format text: HOMOLOGADA A DESISTENCIA DO PEDIDO, SOLICITADA ATRAVES DA PETICAO NO 018090015157/SP DE 26.03.2009.