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WO2009016734A1 - 軽度認知機能障害の検定方法 - Google Patents

軽度認知機能障害の検定方法 Download PDF

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Publication number
WO2009016734A1
WO2009016734A1 PCT/JP2007/064988 JP2007064988W WO2009016734A1 WO 2009016734 A1 WO2009016734 A1 WO 2009016734A1 JP 2007064988 W JP2007064988 W JP 2007064988W WO 2009016734 A1 WO2009016734 A1 WO 2009016734A1
Authority
WO
WIPO (PCT)
Prior art keywords
amyloid
detection
cognitive impairment
mild cognitive
immunoassay
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2007/064988
Other languages
English (en)
French (fr)
Inventor
Takashi Asada
Shigeo Takayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanko Junyaku Co Ltd
Eisai R&D Management Co Ltd
University of Tsukuba NUC
Original Assignee
Sanko Junyaku Co Ltd
Eisai R&D Management Co Ltd
University of Tsukuba NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanko Junyaku Co Ltd, Eisai R&D Management Co Ltd, University of Tsukuba NUC filed Critical Sanko Junyaku Co Ltd
Priority to PCT/JP2007/064988 priority Critical patent/WO2009016734A1/ja
Publication of WO2009016734A1 publication Critical patent/WO2009016734A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

　血中等、生体試料検体中のβ－アミロイドの測定手法を工夫し、ＭＣＩの診断に応用することにある。β－アミロイド１－４２のＣ末端部分を認識する抗体を用いる免疫測定法によって、生体試料検体中の、β－アミロイド１－４２とβ－アミロイド１－４２のＣ末端部分を保有するβ－アミロイド１－４２断片のトータル量を測定することによりＭＣＩの検定を可能とした。前記免疫測定法が、競合的免疫測定法であることが好ましい。
PCT/JP2007/064988 2007-07-31 2007-07-31 軽度認知機能障害の検定方法 Ceased WO2009016734A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/064988 WO2009016734A1 (ja) 2007-07-31 2007-07-31 軽度認知機能障害の検定方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/064988 WO2009016734A1 (ja) 2007-07-31 2007-07-31 軽度認知機能障害の検定方法

Publications (1)

Publication Number Publication Date
WO2009016734A1 true WO2009016734A1 (ja) 2009-02-05

Family

ID=40303979

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/064988 Ceased WO2009016734A1 (ja) 2007-07-31 2007-07-31 軽度認知機能障害の検定方法

Country Status (1)

Country Link
WO (1) WO2009016734A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093001A1 (ja) * 2009-02-13 2010-08-19 国立大学法人大阪大学 アルツハイマー病の診断方法および診断薬
WO2014136443A1 (ja) * 2013-03-08 2014-09-12 パナソニックヘルスケア株式会社 抗Ａβ４２モノクローナル抗体
CN111393524A (zh) * 2020-02-20 2020-07-10 北京化工大学 基于金属标记的阿尔兹海默症脑组织Aβ蛋白的原位检测方法
JPWO2022102654A1 (ja) * 2020-11-10 2022-05-19

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006046644A1 (ja) * 2004-10-28 2006-05-04 Sanko Junyaku Co., Ltd. アルツハイマー病の検定方法及び診断試薬

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006046644A1 (ja) * 2004-10-28 2006-05-04 Sanko Junyaku Co., Ltd. アルツハイマー病の検定方法及び診断試薬

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ASADA T. ET AL.: "Alzheimer-byo no Shojo to Soki Hakken", MOLECULAR MEDICINE, vol. 37, no. 9, 2000, pages 986 - 990, XP003024136 *
ASADA T.: "Dai 2 Kai Hataraki Zakari to Koreisha no Kenko Anshin Bunkakai", SHINKENKO FRONTIER SENRYAKU KENJIN KAIGI, 2 February 2007 (2007-02-02), XP003024135, Retrieved from the Internet <URL:http://www.kantei.go.jp/jp/singi/kenkou/index.html> *
KUDO K.: "Keido Ninchi Shogai - Alzheimer-gata Ninchisho no Shoki, Sono Zenku Jotai o Chushin ni Kongo no Gazo Shindan", MODERN PHYSICIAN, vol. 26, no. 12, 2006, pages 1835 - 1838, XP003024140 *
ODAKA A. ET AL.: "Amyloid beta-protein no C-mattan Tokuiteki Koso Men'eki Sokutei Ho", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 33, no. 1, 1994, pages 232 - 233, XP003024138 *
SHOJI M. ET AL.: "Alzheimer-byo no Shindan Marker (Nosekizuieki to Kessho)", MEBIO, vol. 23, no. 6, 2006, pages 82 - 89, XP003024137 *
SHOJI M.: "Keido Ninchi Shogai - Alzheimer-gata Ninchisho no Shoki, Sono Zenku Jotai o Chushin ni Shindan Marker", MODERN PHYSICIAN, vol. 26, no. 12, 2006, pages 1839 - 1841, XP003024134 *
URAKAMI K.: "Keido Ninchi Shogai (MCI)", MODERN PHYSICIAN, vol. 26, no. 8, 2006, pages 1376 - 1383, XP003024139 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010093001A1 (ja) * 2009-02-13 2010-08-19 国立大学法人大阪大学 アルツハイマー病の診断方法および診断薬
WO2014136443A1 (ja) * 2013-03-08 2014-09-12 パナソニックヘルスケア株式会社 抗Ａβ４２モノクローナル抗体
CN111393524A (zh) * 2020-02-20 2020-07-10 北京化工大学 基于金属标记的阿尔兹海默症脑组织Aβ蛋白的原位检测方法
CN111393524B (zh) * 2020-02-20 2022-04-08 北京化工大学 基于金属标记的阿尔兹海默症脑组织Aβ蛋白的原位检测方法
JPWO2022102654A1 (ja) * 2020-11-10 2022-05-19
WO2022102654A1 (ja) * 2020-11-10 2022-05-19 株式会社Mcbi バイオマーカーの組合せ、及び、当該組合せを用いた認知機能障害又はそのリスクの検出方法
JP7737723B2 (ja) 2020-11-10 2025-09-11 株式会社Mcbi バイオマーカーの組合せ、及び、当該組合せを用いた認知機能障害又はそのリスクの検出方法

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