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BRPI0416030A - pirido-7-pirimidin-7-onas substituìdas com hidroxialquila - Google Patents

pirido-7-pirimidin-7-onas substituìdas com hidroxialquila

Info

Publication number
BRPI0416030A
BRPI0416030A BRPI0416030-4A BRPI0416030A BRPI0416030A BR PI0416030 A BRPI0416030 A BR PI0416030A BR PI0416030 A BRPI0416030 A BR PI0416030A BR PI0416030 A BRPI0416030 A BR PI0416030A
Authority
BR
Brazil
Prior art keywords
pyrimidin
ones
hydroxyalkyl substituted
substituted pyrido
hydroxyalkyl
Prior art date
Application number
BRPI0416030-4A
Other languages
English (en)
Inventor
David Michael Goldstein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0416030A publication Critical patent/BRPI0416030A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"PIRIDO-7-PIRIMIDIN-7-ONAS SUBSTITUìDAS COM HIDROXIALQUILA". A presente invenção refere-se a um composto de fórmula I onde X¬ 1¬, Ar¬ 1¬, R¬ 1¬ e R¬ 2¬ são como aqui definidos, e composições compreendendo os mesmos. A presente invenção também fornece métodos para usar os compostos de fórmula I no tratamento de distúrbios mediados por p38 em um paciente.
BRPI0416030-4A 2003-11-13 2004-11-04 pirido-7-pirimidin-7-onas substituìdas com hidroxialquila BRPI0416030A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51978903P 2003-11-13 2003-11-13
PCT/EP2004/012475 WO2005047284A1 (en) 2003-11-13 2004-11-04 Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones

Publications (1)

Publication Number Publication Date
BRPI0416030A true BRPI0416030A (pt) 2007-01-02

Family

ID=34590444

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0416030-4A BRPI0416030A (pt) 2003-11-13 2004-11-04 pirido-7-pirimidin-7-onas substituìdas com hidroxialquila

Country Status (26)

Country Link
US (2) US7348331B2 (pt)
EP (1) EP1685131B1 (pt)
JP (1) JP4616839B2 (pt)
KR (1) KR100816321B1 (pt)
CN (1) CN100455582C (pt)
AR (1) AR046705A1 (pt)
AT (1) ATE356124T1 (pt)
AU (1) AU2004289428B2 (pt)
BR (1) BRPI0416030A (pt)
CA (1) CA2544247A1 (pt)
CO (1) CO5690600A2 (pt)
DE (1) DE602004005238T2 (pt)
DK (1) DK1685131T3 (pt)
ES (1) ES2281843T3 (pt)
HR (1) HRP20070132T3 (pt)
IL (1) IL175284A0 (pt)
MY (1) MY141011A (pt)
NO (1) NO20062256L (pt)
NZ (1) NZ546634A (pt)
PL (1) PL1685131T3 (pt)
PT (1) PT1685131E (pt)
RU (1) RU2348632C2 (pt)
SI (1) SI1685131T1 (pt)
TW (1) TWI349670B (pt)
WO (1) WO2005047284A1 (pt)
ZA (1) ZA200603829B (pt)

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CA2656507C (en) 2006-07-17 2012-03-20 Amgen Inc. Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors
JP2010513382A (ja) * 2006-12-22 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー アミノ−アルキレンジオール合成のための化合物及び方法
CN101679211A (zh) * 2007-06-15 2010-03-24 霍夫曼-拉罗奇有限公司 用于制备3-氨基-戊-1,5-二醇的新方法
KR101754664B1 (ko) * 2009-12-18 2017-07-06 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 치환된 피리도〔2,3-ｄ〕피리미딘-7(8ｈ)-온스 및 이의 치료 용도
KR102046448B1 (ko) 2014-02-07 2019-11-19 프린시피아 바이오파마, 인코퍼레이티드 섬유모세포 성장 인자 수용체 저해제로서 퀴놀론 유도체들
WO2017027567A1 (en) 2015-08-11 2017-02-16 Principia Biopharma, Inc. Processes for preparing an fgfr inhibitor
CN105418609B (zh) * 2015-12-31 2017-06-23 山东大学 4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用
WO2017151409A1 (en) 2016-02-29 2017-09-08 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods
MY194619A (en) 2016-06-02 2022-12-07 Abbvie Inc Glucocorticoid receptor agonist and immunoconjugates thereof
SG11201809882XA (en) 2016-06-08 2018-12-28 Support Venture Gmbh Pharmaceutical combinations for treating cancer
CN109562105A (zh) 2016-08-17 2019-04-02 企业支持有限责任公司 预防或治疗听力损失的方法
SG10202110804WA (en) * 2017-04-04 2021-11-29 Kinarus Ag Methods of preventing or treating ophthalmic diseases
EP3692144A1 (en) 2017-10-05 2020-08-12 Fulcrum Therapeutics, Inc. Use of p38 inhibitors to reduce expression of dux4
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
BR112020010694A2 (pt) 2017-12-01 2020-11-10 Abbvie Inc. agonista de receptor de glicocorticoides e imunoconjugados do mesmo
JP7304896B2 (ja) 2018-05-21 2023-07-07 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ 複素縮合ピリドン化合物及びｉｄｈ阻害剤としてのこれらの使用
CN112512586A (zh) 2018-07-13 2021-03-16 基纳鲁斯股份公司 用于预防或治疗纤维化疾病的ppar激动剂和p38激酶抑制剂的组合
WO2021089395A1 (en) 2019-11-08 2021-05-14 Nerviano Medical Sciences S.R.L. Gem-disubstituted heterocyclic compounds and their use as idh inhibitors
WO2022034031A1 (en) 2020-08-11 2022-02-17 Kinarus Ag Methods of preventing or treating covid-19 and related viral diseases or disorders

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US4215216A (en) * 1979-04-18 1980-07-29 American Home Products Corporation 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
EP0278686A1 (en) 1987-02-07 1988-08-17 The Wellcome Foundation Limited Pyridopyrimidines methods for their preparation and pharmaceutical formulations thereof
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
WO1993017682A1 (en) 1992-03-04 1993-09-16 Abbott Laboratories Angiotensin ii receptor antagonists
IL115256A0 (en) * 1994-11-14 1995-12-31 Warner Lambert Co 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
ES2146782T3 (es) 1994-11-14 2000-08-16 Warner Lambert Co 6-aril-pirido(2,3-d)pirimidinas y naftiridinas para la inhibicion de la proliferacion celular inducida por la proteina tirosina quinasa.
US5620981A (en) * 1995-05-03 1997-04-15 Warner-Lambert Company Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
IL117923A (en) 1995-05-03 2000-06-01 Warner Lambert Co Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds
ES2301194T3 (es) 1997-02-05 2008-06-16 Warner-Lambert Company Llc Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular.
US5945422A (en) * 1997-02-05 1999-08-31 Warner-Lambert Company N-oxides of amino containing pyrido 2,3-D! pyrimidines
CN1138778C (zh) 1998-05-26 2004-02-18 沃尼尔·朗伯公司 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途
US7053070B2 (en) * 2000-01-25 2006-05-30 Warner-Lambert Company Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
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Also Published As

Publication number Publication date
KR100816321B1 (ko) 2008-03-24
US7348331B2 (en) 2008-03-25
NZ546634A (en) 2010-01-29
RU2348632C2 (ru) 2009-03-10
ATE356124T1 (de) 2007-03-15
RU2006120486A (ru) 2008-01-20
TWI349670B (en) 2011-10-01
US20050107408A1 (en) 2005-05-19
JP4616839B2 (ja) 2011-01-19
JP2007510686A (ja) 2007-04-26
CA2544247A1 (en) 2005-05-26
EP1685131B1 (en) 2007-03-07
PT1685131E (pt) 2007-05-31
HRP20070132T3 (en) 2007-05-31
CO5690600A2 (es) 2006-10-31
HK1099021A1 (zh) 2007-08-03
KR20060086417A (ko) 2006-07-31
SI1685131T1 (sl) 2007-06-30
AU2004289428B2 (en) 2010-06-03
PL1685131T3 (pl) 2007-08-31
CN1882585A (zh) 2006-12-20
NO20062256L (no) 2006-06-06
CN100455582C (zh) 2009-01-28
ZA200603829B (en) 2007-10-31
AU2004289428A1 (en) 2005-05-26
AR046705A1 (es) 2005-12-21
MY141011A (en) 2010-02-25
DE602004005238D1 (de) 2007-04-19
WO2005047284A1 (en) 2005-05-26
US20080119497A1 (en) 2008-05-22
US7750016B2 (en) 2010-07-06
DE602004005238T2 (de) 2007-11-08
TW200526657A (en) 2005-08-16
ES2281843T3 (es) 2007-10-01
IL175284A0 (en) 2006-09-05
EP1685131A1 (en) 2006-08-02
DK1685131T3 (da) 2007-07-09

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.