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BRPI0408059A - sistema de administração de opióides - Google Patents

sistema de administração de opióides

Info

Publication number
BRPI0408059A
BRPI0408059A BRPI0408059-9A BRPI0408059A BRPI0408059A BR PI0408059 A BRPI0408059 A BR PI0408059A BR PI0408059 A BRPI0408059 A BR PI0408059A BR PI0408059 A BRPI0408059 A BR PI0408059A
Authority
BR
Brazil
Prior art keywords
opioid
administration
formulation
pulmonary
delivery system
Prior art date
Application number
BRPI0408059-9A
Other languages
English (en)
Inventor
Orlando Ricardo Hung
Steven Louis Shafer
Diana Helen Pliura
Original Assignee
Delex Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delex Therapeutics Inc filed Critical Delex Therapeutics Inc
Publication of BRPI0408059A publication Critical patent/BRPI0408059A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Paper (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"SISTEMA DE ADMINISTRACãO DE OPIóIDES". Uma formulação de opióide para administração pulmonar no tratamento ou gerenciamento de dor, que contém um dispositivo de administração de fármaco pulmonar, método de administração, que contém um kit e usos da mesma. A formulação contém pelo menos um opióide de início rápido e preferivelmente também contém um opióide de efeito prolongado para reduzir a freqüência de administração. A invenção emprega os efeitos colaterais da formulação de opióide para permitir que os pacientes autolimitem a ingestão de fármaco e, com isso, evite a toxicidade enquanto se atinge analgesia. Emprega-se um modelo farmacocinético e farmacodinâmico para determinar as formulações de fármaco ideais e os parâmetros ideais para administração.
BRPI0408059-9A 2003-02-28 2004-03-01 sistema de administração de opióides BRPI0408059A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45033303P 2003-02-28 2003-02-28
PCT/CA2004/000303 WO2004075879A1 (en) 2003-02-28 2004-03-01 Opioid delivery system

Publications (1)

Publication Number Publication Date
BRPI0408059A true BRPI0408059A (pt) 2006-02-14

Family

ID=32927636

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408059-9A BRPI0408059A (pt) 2003-02-28 2004-03-01 sistema de administração de opióides

Country Status (19)

Country Link
EP (1) EP1603533B1 (pt)
JP (1) JP2006519185A (pt)
KR (1) KR20050114221A (pt)
CN (1) CN1780605A (pt)
AT (1) ATE428402T1 (pt)
AU (1) AU2004216550B2 (pt)
BR (1) BRPI0408059A (pt)
CA (1) CA2556629A1 (pt)
CY (1) CY1109215T1 (pt)
DE (1) DE602004020597D1 (pt)
DK (1) DK1603533T3 (pt)
ES (1) ES2325834T3 (pt)
IL (1) IL177764A0 (pt)
MX (1) MXPA05009179A (pt)
NZ (1) NZ542005A (pt)
PT (1) PT1603533E (pt)
RU (1) RU2362559C2 (pt)
WO (1) WO2004075879A1 (pt)
ZA (1) ZA200607418B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques
EP2039360A1 (en) * 2007-09-19 2009-03-25 Euro-Celtique S.A. Non-invasive direct delivery of opioids to the central nervous system
GB0919893D0 (en) * 2009-11-13 2009-12-30 Biocopea Ltd Drug composition and its use in therapy
KR101298303B1 (ko) * 2010-04-27 2013-08-20 울산대학교 산학협력단 약물의 약동-약력학적 모델링을 위한 통합 분석 시스템
DE102012009617B4 (de) 2012-05-15 2020-03-26 Drägerwerk AG & Co. KGaA Datenverarbeitungseinrichtung für eine Anästhesievorrichtung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8900267D0 (en) * 1989-01-06 1989-03-08 Riker Laboratories Inc Narcotic analgesic formulations and apparatus containing same
US5451408A (en) * 1994-03-23 1995-09-19 Liposome Pain Management, Ltd. Pain management with liposome-encapsulated analgesic drugs
CA2189351C (en) * 1994-05-13 2008-12-30 Stephen J. Farr Narcotic containing aerosol formulation
GB9415810D0 (en) * 1994-08-04 1994-09-28 Jerrow Mohammad A Z Composition
GB9606188D0 (en) * 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
ES2207867T3 (es) * 1998-12-11 2004-06-01 Pharmachemie B.V. Preparacion farmaceutica para inhalacion de un opioide.
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound

Also Published As

Publication number Publication date
JP2006519185A (ja) 2006-08-24
NZ542005A (en) 2009-05-31
RU2362559C2 (ru) 2009-07-27
ATE428402T1 (de) 2009-05-15
CA2556629A1 (en) 2004-09-10
CN1780605A (zh) 2006-05-31
ES2325834T3 (es) 2009-09-21
EP1603533A1 (en) 2005-12-14
AU2004216550B2 (en) 2010-06-03
ZA200607418B (en) 2008-01-30
AU2004216550A1 (en) 2004-09-10
PT1603533E (pt) 2009-07-23
DK1603533T3 (da) 2009-08-17
IL177764A0 (en) 2007-03-08
HK1084341A1 (en) 2006-07-28
DE602004020597D1 (de) 2009-05-28
CY1109215T1 (el) 2014-07-02
WO2004075879A1 (en) 2004-09-10
EP1603533B1 (en) 2009-04-15
MXPA05009179A (es) 2006-03-08
RU2005130166A (ru) 2006-06-10
KR20050114221A (ko) 2005-12-05

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: YM BIOSCIENCES INC. (CA)

Free format text: TRANSFERIDO DE: DELEX THERAPEUTICS INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.