BRPI9711856B8 - métodos para preparação de um agente ativo, substancialmente insolúvel em água e composição para liberação in vivo de um agente ativo - Google Patents
métodos para preparação de um agente ativo, substancialmente insolúvel em água e composição para liberação in vivo de um agente ativoInfo
- Publication number
- BRPI9711856B8 BRPI9711856B8 BRPI9711856A BR9711856A BRPI9711856B8 BR PI9711856 B8 BRPI9711856 B8 BR PI9711856B8 BR PI9711856 A BRPI9711856 A BR PI9711856A BR 9711856 A BR9711856 A BR 9711856A BR PI9711856 B8 BRPI9711856 B8 BR PI9711856B8
- Authority
- BR
- Brazil
- Prior art keywords
- active agent
- pharmacologically active
- preparing
- composition
- methods
- Prior art date
Links
- 239000013543 active substance Substances 0.000 title abstract 5
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000001727 in vivo Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 239000011162 core material Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002105 nanoparticle Substances 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Nutrition Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Pediatric Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
patente de invenção: "agentes farmacologicamente ativos estabilizados com proteína, processos para a sua preparação e processos para o seu uso". de acordo com a presente invenção são providos composições e processos para liberação in vivo de agentes farmacologicamente ativos substancialmente insolúveis em água (tais como paclitaxel de drogas anticâncer) nos quais o agente farmacologicamente ativo é liberado na forma de partículas suspensas revestidas com proteína (que agem como um agente estabilizador) . em particular, a proteína e o agente farmacologicamente ativo em um meio dispersante biocompatível são submetidos a alto cisalhamento, na ausência de qualquer tensoativo convencional e também na ausência de qualquer material de núcleo polimérico para as partículas. o procedimento produz partículas com diâmetro menor do que 1 mícron. o uso de composição e de preparação específicas (por exemplo, adição de um solvente polar à fase orgânica) e uma seleção cuidadosa da fase orgânica apropriada permite a produção reproduzível de nanopartículas especialmente pequenas de menos do que 200 nm de diâmetro, as quais podem ser filtradas sob condições estéreis. o sistema de partícula produzido de acordo com a presente invenção pode ser convertido em um pó seco redispersável compreendendo nanopartículas de droga insolúvel em água revestidas com proteína e uma proteína livre à qual as moléculas do referido agente farmacologicamente ativo está associado. isto resulta em um sistema único de liberação no qual parte do agente farmacologicamente ativo está rapidamente biodisponível (na forma de moléculas ligadas a uma proteína) e parte do agente está presente dentro de partículas sem qualquer matriz polimérica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/720,756 US5916596A (en) | 1993-02-22 | 1996-10-01 | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
| PCT/US1997/017157 WO1998014174A1 (en) | 1996-10-01 | 1997-09-24 | Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR9711856A BR9711856A (pt) | 2001-11-06 |
| BRPI9711856B1 BRPI9711856B1 (pt) | 2016-07-12 |
| BRPI9711856B8 true BRPI9711856B8 (pt) | 2021-05-25 |
Family
ID=24895164
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9715297A BRPI9715297B8 (pt) | 1996-10-01 | 1997-09-24 | composição compreendendo partículas de agente farmacologicamente ativo, uso da mesma, cateter intravenoso, frasco selado e emulsão compreendendo um agente farmacologicamente ativo |
| BRPI9711856A BRPI9711856B8 (pt) | 1996-10-01 | 1997-09-24 | métodos para preparação de um agente ativo, substancialmente insolúvel em água e composição para liberação in vivo de um agente ativo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9715297A BRPI9715297B8 (pt) | 1996-10-01 | 1997-09-24 | composição compreendendo partículas de agente farmacologicamente ativo, uso da mesma, cateter intravenoso, frasco selado e emulsão compreendendo um agente farmacologicamente ativo |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5916596A (pt) |
| EP (3) | EP2286798A1 (pt) |
| JP (2) | JP4837809B2 (pt) |
| CN (2) | CN1515244B (pt) |
| AT (1) | ATE427739T1 (pt) |
| AU (1) | AU718753B2 (pt) |
| BR (2) | BRPI9715297B8 (pt) |
| CA (2) | CA2267498C (pt) |
| DE (2) | DE69739348D1 (pt) |
| DK (1) | DK0961612T4 (pt) |
| ES (2) | ES2323559T5 (pt) |
| FR (1) | FR09C0050I2 (pt) |
| LU (1) | LU91613I2 (pt) |
| NL (1) | NL300417I1 (pt) |
| NO (1) | NO328689B1 (pt) |
| NZ (1) | NZ335133A (pt) |
| PT (1) | PT961612E (pt) |
| WO (1) | WO1998014174A1 (pt) |
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1996
- 1996-10-01 US US08/720,756 patent/US5916596A/en not_active Expired - Lifetime
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1997
- 1997-09-24 NZ NZ335133A patent/NZ335133A/xx not_active IP Right Cessation
- 1997-09-24 ES ES97944429T patent/ES2323559T5/es not_active Expired - Lifetime
- 1997-09-24 BR BRPI9715297A patent/BRPI9715297B8/pt not_active IP Right Cessation
- 1997-09-24 JP JP51665798A patent/JP4837809B2/ja not_active Expired - Lifetime
- 1997-09-24 EP EP10011100A patent/EP2286798A1/en not_active Withdrawn
- 1997-09-24 CN CN200310123461XA patent/CN1515244B/zh not_active Expired - Lifetime
- 1997-09-24 WO PCT/US1997/017157 patent/WO1998014174A1/en not_active Ceased
- 1997-09-24 DE DE69739348T patent/DE69739348D1/de not_active Expired - Lifetime
- 1997-09-24 ES ES08006374.6T patent/ES2609853T3/es not_active Expired - Lifetime
- 1997-09-24 DK DK97944429.6T patent/DK0961612T4/da active
- 1997-09-24 AT AT97944429T patent/ATE427739T1/de active
- 1997-09-24 EP EP97944429A patent/EP0961612B2/en not_active Expired - Lifetime
- 1997-09-24 CA CA002267498A patent/CA2267498C/en not_active Expired - Lifetime
- 1997-09-24 PT PT97944429T patent/PT961612E/pt unknown
- 1997-09-24 EP EP08006374.6A patent/EP1944019B1/en not_active Expired - Lifetime
- 1997-09-24 CN CNB971997209A patent/CN1157185C/zh not_active Expired - Lifetime
- 1997-09-24 CA CA2512487A patent/CA2512487C/en not_active Expired - Lifetime
- 1997-09-24 DE DE122009000065C patent/DE122009000065I1/de active Pending
- 1997-09-24 BR BRPI9711856A patent/BRPI9711856B8/pt not_active IP Right Cessation
- 1997-09-24 AU AU45929/97A patent/AU718753B2/en not_active Expired
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1999
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- 2009-10-06 FR FR09C0050C patent/FR09C0050I2/fr active Active
- 2009-10-07 LU LU91613C patent/LU91613I2/fr unknown
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