BR9917006A - liposomal niflumic acid - transdermal anti-inflammatory drug - Google Patents
liposomal niflumic acid - transdermal anti-inflammatory drugInfo
- Publication number
- BR9917006A BR9917006A BR9917006-0A BR9917006A BR9917006A BR 9917006 A BR9917006 A BR 9917006A BR 9917006 A BR9917006 A BR 9917006A BR 9917006 A BR9917006 A BR 9917006A
- Authority
- BR
- Brazil
- Prior art keywords
- niflumic acid
- liposomes
- transdermal
- liposomal
- inflammatory drug
- Prior art date
Links
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 title abstract 3
- 229960000916 niflumic acid Drugs 0.000 title abstract 3
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 229940124599 anti-inflammatory drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 3
- 239000002502 liposome Substances 0.000 abstract 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000013020 final formulation Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: "áCIDO NIFLúMICO LIPOSSÈMICO -MEDICAMENTO ANTIINFLAMATóRIO TRANSDéRMICO". Apresente invenção refere-se à encapsulação da droga ácidoniflúmico em lipossomas com o propósito de criar uma formulaçãoantiinflamatória não esteroidal transdérmica nova. O ácidoniflúmico, bem como seus derivados de ésteres, têm sidoencapsulados em lipossomas com diferentes formulações lipídicasa fim de se alcançar uma efetividade aumentada do compostoativo. A suspensão de lipossomas, com ou sem a drogaencapsulada, tem sido formulada como um creme e um estudo deestabilidade da formulação final tem sido realizado.Invention Patent: "LIPOSEMIC NIFLUMIC ACID - TRANSDERMAL ANTIINFLAMMATORY MEDICATION". The present invention relates to the encapsulation of the nephlumic acid drug in liposomes for the purpose of creating a new transdermal non-steroidal anti-inflammatory formulation. Niflumic acid, as well as its ester derivatives, has been encapsulated in liposomes with different lipid formulations in order to achieve an increased effectiveness of the active compound. The suspension of liposomes, with or without the encapsulated drug, has been formulated as a cream and a stability study of the final formulation has been carried out.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR98100469 | 1998-12-24 | ||
| PCT/GR1999/000048 WO2000038681A1 (en) | 1998-12-24 | 1999-12-22 | Liposomic niflumic acid - new transdermal anti-inflammatory medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9917006A true BR9917006A (en) | 2001-10-30 |
Family
ID=10943556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9917006-0A BR9917006A (en) | 1998-12-24 | 1999-12-22 | liposomal niflumic acid - transdermal anti-inflammatory drug |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1140089A1 (en) |
| JP (1) | JP2002533394A (en) |
| KR (1) | KR20010089889A (en) |
| CN (1) | CN1331592A (en) |
| AU (1) | AU1673400A (en) |
| BR (1) | BR9917006A (en) |
| CA (1) | CA2357765A1 (en) |
| CZ (1) | CZ20012240A3 (en) |
| GR (1) | GR1003359B (en) |
| HU (1) | HUP0104853A3 (en) |
| IL (1) | IL143499A0 (en) |
| IS (1) | IS5964A (en) |
| MX (1) | MXPA01006462A (en) |
| NO (1) | NO20013015D0 (en) |
| PL (1) | PL349344A1 (en) |
| SK (1) | SK7962001A3 (en) |
| WO (1) | WO2000038681A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100367932C (en) * | 2002-11-26 | 2008-02-13 | 吉里德科学公司 | Method for Drug Loading in Liposomes by Gradients |
| CA2523413A1 (en) | 2003-04-25 | 2004-11-11 | The Penn State Research Foundation | Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds |
| US20050255154A1 (en) | 2004-05-11 | 2005-11-17 | Lena Pereswetoff-Morath | Method and composition for treating rhinitis |
| JP4791082B2 (en) * | 2005-05-30 | 2011-10-12 | 株式会社クラレ | Liposomes and topical skin preparations containing the same |
| JP4931369B2 (en) * | 2005-05-31 | 2012-05-16 | ポーラ化成工業株式会社 | Liposomes and therapeutic compositions containing the same |
| JP5846711B2 (en) | 2005-06-09 | 2016-01-20 | メダ アーベー | Methods and compositions for the treatment of inflammatory diseases |
| US20120028335A1 (en) | 2010-07-28 | 2012-02-02 | Life Technologies Corporation | Anti-viral azide-containing compounds |
| CN103237546B (en) | 2010-07-28 | 2016-06-08 | 生命科技公司 | The antiviral compound that contains azide |
| EP2807252B1 (en) | 2012-01-26 | 2017-05-10 | Life Technologies Corporation | Methods for increasing the infectivity of viruses |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528193A (en) * | 1978-12-27 | 1985-07-09 | A. Natterman & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
| EP0225162B1 (en) * | 1985-11-27 | 1992-01-22 | Ethicon, Inc. | Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug |
| ES2036593T3 (en) * | 1986-06-12 | 1993-06-01 | The Liposome Company, Inc. | COMPOSITIONS USING NON-STEROID ANTI-INFLAMMATORY MEDICINES ENCAPSULATED IN LIPOSOMES. |
| EP0825852B1 (en) * | 1995-04-18 | 2004-07-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
-
1998
- 1998-12-24 GR GR980100469A patent/GR1003359B/en not_active IP Right Cessation
-
1999
- 1999-12-22 CZ CZ20012240A patent/CZ20012240A3/en unknown
- 1999-12-22 KR KR1020017008144A patent/KR20010089889A/en not_active Withdrawn
- 1999-12-22 JP JP2000590635A patent/JP2002533394A/en active Pending
- 1999-12-22 WO PCT/GR1999/000048 patent/WO2000038681A1/en not_active Ceased
- 1999-12-22 PL PL99349344A patent/PL349344A1/en not_active Application Discontinuation
- 1999-12-22 EP EP99959605A patent/EP1140089A1/en not_active Withdrawn
- 1999-12-22 AU AU16734/00A patent/AU1673400A/en not_active Abandoned
- 1999-12-22 SK SK796-2001A patent/SK7962001A3/en unknown
- 1999-12-22 BR BR9917006-0A patent/BR9917006A/en not_active Application Discontinuation
- 1999-12-22 CN CN99814948A patent/CN1331592A/en active Pending
- 1999-12-22 MX MXPA01006462A patent/MXPA01006462A/en unknown
- 1999-12-22 HU HU0104853A patent/HUP0104853A3/en unknown
- 1999-12-22 IL IL14349999A patent/IL143499A0/en unknown
- 1999-12-22 CA CA002357765A patent/CA2357765A1/en not_active Abandoned
-
2001
- 2001-06-08 IS IS5964A patent/IS5964A/en unknown
- 2001-06-18 NO NO20013015A patent/NO20013015D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PL349344A1 (en) | 2002-07-15 |
| KR20010089889A (en) | 2001-10-12 |
| IL143499A0 (en) | 2002-04-21 |
| HUP0104853A3 (en) | 2003-05-28 |
| MXPA01006462A (en) | 2002-06-04 |
| WO2000038681A1 (en) | 2000-07-06 |
| GR1003359B (en) | 2000-04-10 |
| IS5964A (en) | 2001-06-08 |
| AU1673400A (en) | 2000-07-31 |
| SK7962001A3 (en) | 2002-02-05 |
| NO20013015L (en) | 2001-06-18 |
| JP2002533394A (en) | 2002-10-08 |
| CA2357765A1 (en) | 2000-07-06 |
| HUP0104853A2 (en) | 2002-05-29 |
| CZ20012240A3 (en) | 2001-11-14 |
| CN1331592A (en) | 2002-01-16 |
| EP1140089A1 (en) | 2001-10-10 |
| NO20013015D0 (en) | 2001-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |