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BR9911351A - Formulações farmacêuticas para aerossóis com duas ou mais substâncias ativas - Google Patents

Formulações farmacêuticas para aerossóis com duas ou mais substâncias ativas

Info

Publication number
BR9911351A
BR9911351A BR9911351-1A BR9911351A BR9911351A BR 9911351 A BR9911351 A BR 9911351A BR 9911351 A BR9911351 A BR 9911351A BR 9911351 A BR9911351 A BR 9911351A
Authority
BR
Brazil
Prior art keywords
active substances
aerosols
pharmaceutical formulations
active substance
active
Prior art date
Application number
BR9911351-1A
Other languages
English (en)
Inventor
Daniel Patrick Mcnamara
George A Destefano
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26046888&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9911351(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE1998127178 external-priority patent/DE19827178A1/de
Priority claimed from DE1998142963 external-priority patent/DE19842963A1/de
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR9911351A publication Critical patent/BR9911351A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Patente de Invenção: <B>"FORMULAçõES FARMACêUTICAS PARA AEROSSóIS COM DUAS OU MAIS SUBSTâNCIAS ATIVAS"<D>. A presente invenção refere-se a novas formulações farmacêuticas para aerossóis com pelo menos duas ou mais substâncias ativas para administração por inalação ou por via nasal. Especificamente, a invenção refere-se a preparações farmacêuticas para aerossóis de doses medidas acionados por propelente usando flúor-hidrocarboneto (HFC) como propelente, que contém uma combinação de substância ativa de duas ou mais substâncias ativas, em que pelo menos uma substância ativa está presente na forma dissolvida junto com pelo menos uma outra substância ativa na forma de partículas colocadas em suspensão.
BR9911351-1A 1998-06-18 1999-06-08 Formulações farmacêuticas para aerossóis com duas ou mais substâncias ativas BR9911351A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998127178 DE19827178A1 (de) 1998-06-18 1998-06-18 Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen
DE1998142963 DE19842963A1 (de) 1998-09-19 1998-09-19 Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen
PCT/US1999/012785 WO1999065464A1 (en) 1998-06-18 1999-06-08 Pharmaceutical formulations for aerosols with two or more active substances

Publications (1)

Publication Number Publication Date
BR9911351A true BR9911351A (pt) 2001-03-13

Family

ID=26046888

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9911351-1A BR9911351A (pt) 1998-06-18 1999-06-08 Formulações farmacêuticas para aerossóis com duas ou mais substâncias ativas

Country Status (32)

Country Link
EP (1) EP1087750B1 (pt)
JP (1) JP2003522102A (pt)
KR (1) KR100600423B1 (pt)
CN (1) CN1161104C (pt)
AR (1) AR019690A1 (pt)
AT (1) ATE253896T1 (pt)
AU (1) AU759222B2 (pt)
BG (1) BG65252B1 (pt)
BR (1) BR9911351A (pt)
CA (1) CA2335065C (pt)
CO (1) CO5070580A1 (pt)
CZ (1) CZ300910B6 (pt)
DE (1) DE69912781T2 (pt)
DK (1) DK1087750T3 (pt)
EE (1) EE04450B1 (pt)
ES (1) ES2211108T3 (pt)
HR (1) HRP20000867B1 (pt)
HU (1) HU229064B1 (pt)
ID (1) ID27554A (pt)
IL (2) IL140353A0 (pt)
ME (1) ME00838B (pt)
MY (1) MY121073A (pt)
NO (1) NO329416B1 (pt)
NZ (1) NZ509418A (pt)
PL (1) PL193695B1 (pt)
PT (1) PT1087750E (pt)
RS (1) RS49977B (pt)
RU (1) RU2218152C2 (pt)
SK (1) SK284756B6 (pt)
TR (1) TR200003721T2 (pt)
TW (1) TW528606B (pt)
WO (1) WO1999065464A1 (pt)

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GB9616237D0 (en) 1996-08-01 1996-09-11 Norton Healthcare Ltd Aerosol formulations
US20010031244A1 (en) 1997-06-13 2001-10-18 Chiesi Farmaceutici S.P.A. Pharmaceutical aerosol composition
GB2332372B (en) * 1997-12-08 2002-08-14 Minnesota Mining & Mfg Pharmaceutical aerosol compositions
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US7214687B2 (en) 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
IT1313553B1 (it) 1999-07-23 2002-09-09 Chiesi Farma Spa Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione.
WO2001019342A2 (en) 1999-09-11 2001-03-22 Glaxo Group Limited Pharmaceutical formulation of fluticasone propionate
ATE286716T1 (de) * 1999-11-23 2005-01-15 Glaxo Group Ltd Pharmazeutische formulierungen enthaltend salmeterol
WO2001047493A1 (en) * 1999-12-24 2001-07-05 Glaxo Group Limited Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate
IT1317846B1 (it) 2000-02-22 2003-07-15 Chiesi Farma Spa Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva.
GB0008485D0 (en) * 2000-04-07 2000-05-24 Glaxo Group Ltd Pharmaceutical compositions
DZ3358A1 (fr) * 2000-05-22 2001-11-29 Chiesi Farma Spa Formulations en solution pharmaceutiques pour inhalateurs-doseurs sous pression
DE10062712A1 (de) * 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
DE10130371A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
BRPI0212586B8 (pt) 2001-09-18 2021-05-25 Nycomed Danmark Aps composição na forma de uma solução aquosa, e, uso da mesma
JP2010184937A (ja) * 2001-10-26 2010-08-26 Dey Lp 慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、キット、吸入溶液を中に有する１容器を作成する方法、および、吸入溶液を作成する方法
GB0207899D0 (en) * 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and cielesonide aerosol formulations
EP1915985A1 (en) * 2003-03-20 2008-04-30 Boehringer Ingelheim Pharmaceuticals Inc. Formulation for a Metered Dose Inhaler Using Hydro-Fluoro-Alkanes as Propellants
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US9308199B2 (en) * 2004-04-29 2016-04-12 Honeywell International Inc. Medicament formulations
EP1595531A1 (en) 2004-05-13 2005-11-16 CHIESI FARMACEUTICI S.p.A. Stable pharmaceutical solution formulations for pressurized metered dose inhalers
WO2006101882A2 (en) * 2005-03-16 2006-09-28 Honeywell International Inc. Medicament delivery formulations, devices and methods
DE102006053374A1 (de) * 2006-02-09 2007-08-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische Formulierung für Aerosole mit zwei oder mehr Wirkstoffen und mindestens einer oberflächenaktiven Substanz
DE102006017320A1 (de) 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
US8061350B2 (en) 2006-06-02 2011-11-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process and device for dosing pharmaceutical agents
US20070286814A1 (en) * 2006-06-12 2007-12-13 Medispray Laboratories Pvt. Ltd. Stable aerosol pharmaceutical formulations
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
RU2356537C2 (ru) * 2007-07-25 2009-05-27 Закрытое Акционерное Общество (ЗАО) "Пульмомед" Фармацевтический состав дозированных аэрозолей, содержащий противоастматические лекарственные средства в виде суспензий, растворов, эмульсий, растворов и эмульсий
EP2077132A1 (en) 2008-01-02 2009-07-08 Boehringer Ingelheim Pharma GmbH & Co. KG Dispensing device, storage device and method for dispensing a formulation
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2408500B1 (en) 2009-03-17 2015-04-29 Boehringer Ingelheim International GmbH Dispensing device, and storage device for dispensing a formulation
WO2010112358A2 (de) 2009-03-31 2010-10-07 Boehringer Ingelheim International Gmbh Verfahren zur beschichtung einer oberfläche eines bauteils
EP3508239B1 (de) 2009-05-18 2020-12-23 Boehringer Ingelheim International GmbH Adapter, inhalationseinrichtung und zerstäuber
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
AU2010323220B2 (en) 2009-11-25 2015-04-23 Boehringer Ingelheim International Gmbh Nebulizer
WO2011064163A1 (en) 2009-11-25 2011-06-03 Boehringer Ingelheim International Gmbh Nebulizer
EP2512438B1 (en) 2009-12-16 2017-01-25 3M Innovative Properties Company Formulations and methods for controlling mdi particle size delivery
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
EP2694220B1 (de) 2011-04-01 2020-05-06 Boehringer Ingelheim International GmbH Medizinisches gerät mit behälter
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
WO2013152894A1 (de) 2012-04-13 2013-10-17 Boehringer Ingelheim International Gmbh Zerstäuber mit kodiermitteln
ES2836977T3 (es) 2013-08-09 2021-06-28 Boehringer Ingelheim Int Nebulizador
JP6643231B2 (ja) 2013-08-09 2020-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ネブライザ
SG11201608891RA (en) 2014-05-07 2016-11-29 Boehringer Ingelheim Int Nebulizer, indicator device and container
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
EP3139979B1 (en) 2014-05-07 2023-07-05 Boehringer Ingelheim International GmbH Unit, nebulizer and method
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Also Published As

Publication number Publication date
ME00838B (me) 2008-09-29
ES2211108T3 (es) 2004-07-01
ATE253896T1 (de) 2003-11-15
CN1307470A (zh) 2001-08-08
NO20006318L (no) 2001-01-30
JP2003522102A (ja) 2003-07-22
IL140353A0 (en) 2002-02-10
TW528606B (en) 2003-04-21
ID27554A (id) 2001-04-12
DE69912781T2 (de) 2004-10-21
BG105033A (bg) 2001-09-28
AR019690A1 (es) 2002-03-13
HU229064B1 (en) 2013-07-29
DK1087750T3 (da) 2004-01-26
EE04450B1 (et) 2005-04-15
TR200003721T2 (tr) 2001-06-21
IL140353A (en) 2006-09-05
SK284756B6 (sk) 2005-11-03
CZ20004750A3 (en) 2001-05-16
BG65252B1 (bg) 2007-10-31
CA2335065A1 (en) 1999-12-23
PT1087750E (pt) 2004-02-27
EE200000759A (et) 2002-04-15
NO20006318D0 (no) 2000-12-12
HRP20000867B1 (en) 2010-10-31
EP1087750A1 (en) 2001-04-04
SK19392000A3 (sk) 2001-07-10
KR100600423B1 (ko) 2006-07-13
NO329416B1 (no) 2010-10-18
CN1161104C (zh) 2004-08-11
MY121073A (en) 2005-12-30
CZ300910B6 (cs) 2009-09-09
HK1037974A1 (en) 2002-03-01
HUP0104734A2 (hu) 2002-05-29
AU4552199A (en) 2000-01-05
YU80000A (sh) 2003-04-30
HUP0104734A3 (en) 2003-05-28
AU759222B2 (en) 2003-04-10
KR20010072621A (ko) 2001-07-31
WO1999065464A1 (en) 1999-12-23
CA2335065C (en) 2008-06-03
RS49977B (sr) 2008-09-29
DE69912781D1 (de) 2003-12-18
CO5070580A1 (es) 2001-08-28
NZ509418A (en) 2003-06-30
EP1087750B1 (en) 2003-11-12
HRP20000867A2 (en) 2001-10-31
PL193695B1 (pl) 2007-03-30
RU2218152C2 (ru) 2003-12-10
PL345685A1 (en) 2002-01-02

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11 S 2O E 13 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.