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BR9909377A - Composto de multiaglutinação farmacêutica, método para sua preparação, composição e isÈmero (s) do mesmo, e método para produzir anestesia local em um mamìfero - Google Patents

Composto de multiaglutinação farmacêutica, método para sua preparação, composição e isÈmero (s) do mesmo, e método para produzir anestesia local em um mamìfero

Info

Publication number
BR9909377A
BR9909377A BR9909377-4A BR9909377A BR9909377A BR 9909377 A BR9909377 A BR 9909377A BR 9909377 A BR9909377 A BR 9909377A BR 9909377 A BR9909377 A BR 9909377A
Authority
BR
Brazil
Prior art keywords
multiaglutination
local anesthesia
pharmaceutical
compound
preparation
Prior art date
Application number
BR9909377-4A
Other languages
English (en)
Inventor
Sabine M Axt
Timothy J Church
Witold Hruzewicz
John R Jacobsen
Thomas E Jenkins
Yu-Hua Ji
J Kevin Judice
Original Assignee
Advanced Medicine Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Medicine Inc filed Critical Advanced Medicine Inc
Publication of BR9909377A publication Critical patent/BR9909377A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

<B>COMPOSTO DE MULTIAGLUTINAçãO FARMACêUTICA, MéTODO PARA SUA PREPARAçãO, COMPOSIçãO E ISÈMERO (S) DO MESMO, E MéTODO PARA PRODUZIR ANESTESIA LOCAL EM UM MAMìFERO<D> São revelados novos compostos, composições farmacêuticas e métodos para produzir anestesia local de longa duração. Os compostos da presente invenção são compostos de multiaglutinação que compreendem de 2 a 10 ligantes fixados de forma covalente a um ligador ou ligadores, cada ligante sendo capaz de se aglutinar a um sítio de aglutinação de ligante em um canal Na+ de desbloqueio de voltagem para modular os processos biológicos/funções do mesmo.
BR9909377-4A 1998-04-03 1999-04-02 Composto de multiaglutinação farmacêutica, método para sua preparação, composição e isÈmero (s) do mesmo, e método para produzir anestesia local em um mamìfero BR9909377A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8053198P 1998-04-03 1998-04-03
US12207599P 1999-03-01 1999-03-01
PCT/US1999/007263 WO1999051565A1 (en) 1998-04-03 1999-04-02 Novel local anesthetic compounds and uses

Publications (1)

Publication Number Publication Date
BR9909377A true BR9909377A (pt) 2000-12-05

Family

ID=26763633

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909377-4A BR9909377A (pt) 1998-04-03 1999-04-02 Composto de multiaglutinação farmacêutica, método para sua preparação, composição e isÈmero (s) do mesmo, e método para produzir anestesia local em um mamìfero

Country Status (16)

Country Link
US (3) US6337423B1 (pt)
EP (1) EP1066245A4 (pt)
JP (1) JP2002510669A (pt)
KR (1) KR20010034737A (pt)
CN (1) CN1295558A (pt)
AR (1) AR014809A1 (pt)
AU (1) AU3464999A (pt)
BR (1) BR9909377A (pt)
CA (1) CA2315946A1 (pt)
CO (1) CO5040088A1 (pt)
HU (1) HUP0102831A2 (pt)
IL (1) IL137411A0 (pt)
NO (1) NO20004961L (pt)
PE (1) PE20000354A1 (pt)
PL (1) PL342991A1 (pt)
WO (1) WO1999051565A1 (pt)

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EP1216242A1 (en) * 1999-10-01 2002-06-26 Advanced Medicine, Inc. Macrocyclic quinazolinones and their use as local anesthetics
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US20030124174A1 (en) * 2001-10-25 2003-07-03 Endo Pharmaceuticals, Inc Method for treating non-neuropathic pain
DE10161644A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh N,N'-disubstituierte Piperazin-Verbindungen
US20050112183A1 (en) * 2003-11-25 2005-05-26 Galer Bradley S. Compositions and methods for treating neuropathic sensory loss
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
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US20100303753A1 (en) * 2007-10-19 2010-12-02 Nektar Therapeutics Oligomer Conjugates of Lidocaine and Its Derivatives
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CN105418489A (zh) * 2016-01-22 2016-03-23 江苏宝众宝达药业有限公司 一种布比卡因的合成方法
CN110092731B (zh) * 2018-01-31 2022-03-04 四川大学华西医院 长链胺取代的二甲基苯铵类化合物、制备、自组装结构及用途
WO2019154287A1 (zh) * 2018-02-11 2019-08-15 四川大学华西医院 一种季铵盐类化合物及其制备方法与用途
CN108514589A (zh) * 2018-06-28 2018-09-11 河南科技大学第附属医院 一种用于局部麻醉的中药麻醉剂
EP3919476B1 (en) 2019-02-01 2024-12-11 West China Hospital, Sichuan University Quaternary ammonium salt compound, preparation method therefor and use thereof
CN112574098B (zh) * 2019-09-30 2022-06-07 四川大学华西医院 一种酰胺化合物及其制备方法和用途
TWI883391B (zh) 2020-02-18 2025-05-11 美商基利科學股份有限公司 抗病毒化合物
CN115135383B (zh) 2020-02-18 2024-06-11 吉利德科学公司 抗病毒化合物
TWI775313B (zh) 2020-02-18 2022-08-21 美商基利科學股份有限公司 抗病毒化合物
CN116113621A (zh) * 2020-07-22 2023-05-12 弗格制药有限公司 氨基酸
CN114075184B (zh) * 2020-08-17 2023-05-05 四川大学华西医院 一种用于麻醉的季铵盐类化合物及其制备方法和用途
CN111909039A (zh) * 2020-09-07 2020-11-10 江苏湘园化工有限公司 一种高位阻效应的脂肪族二元仲胺的制备方法
JP7688152B2 (ja) 2021-04-16 2025-06-03 ギリアード サイエンシーズ， インコーポレイテッド アミドを使用してカルバヌクレオシドを調製する方法
KR20240049311A (ko) 2021-08-18 2024-04-16 길리애드 사이언시즈, 인코포레이티드 인지질 화합물 및 이의 제조 및 사용 방법
CN118851987A (zh) * 2023-04-27 2024-10-29 宜昌人福药业有限责任公司 一种季铵盐化合物、盐型及其应用

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Also Published As

Publication number Publication date
US6337423B1 (en) 2002-01-08
US6495681B1 (en) 2002-12-17
KR20010034737A (ko) 2001-04-25
WO1999051565A1 (en) 1999-10-14
PL342991A1 (en) 2001-07-16
US6576791B1 (en) 2003-06-10
AR014809A1 (es) 2001-03-28
WO1999051565A9 (en) 1999-12-02
PE20000354A1 (es) 2000-05-20
CN1295558A (zh) 2001-05-16
HUP0102831A2 (hu) 2001-12-28
JP2002510669A (ja) 2002-04-09
CO5040088A1 (es) 2001-05-29
CA2315946A1 (en) 1999-10-14
EP1066245A1 (en) 2001-01-10
EP1066245A4 (en) 2001-01-24
IL137411A0 (en) 2001-07-24
AU3464999A (en) 1999-10-25
NO20004961D0 (no) 2000-10-02
NO20004961L (no) 2000-10-02

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Legal Events

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