BR9908959A - Processo para a produição de derivados de purina - Google Patents
Processo para a produição de derivados de purinaInfo
- Publication number
- BR9908959A BR9908959A BR9908959-9A BR9908959A BR9908959A BR 9908959 A BR9908959 A BR 9908959A BR 9908959 A BR9908959 A BR 9908959A BR 9908959 A BR9908959 A BR 9908959A
- Authority
- BR
- Brazil
- Prior art keywords
- 12alkyl
- formula
- compound
- production
- hydrogen
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
- 125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 aryl carbonate Chemical compound 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical class 0.000 abstract 1
- 125000005116 aryl carbamoyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005104 aryl silyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229960004396 famciclovir Drugs 0.000 abstract 1
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 229960001179 penciclovir Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000006462 rearrangement reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Patente de Invenção: <B>"PROCESSO PARA A PRODUçãO DE DERIVADOS DE PURINA"<D>. A presente invenção proporciona um método de restruturação de um composto da fórmula (I) em que R e R' são selecionados, independentemente, de hidrogênio e C~ 1-12~ alquila; e R~ 1~ e R~ 2~ são selecionados, independentemente, de hidrogênio, hidróxi, halo, C~ 1-12~ alquil- ou arilcarbonato, amino, mono- ou di-C~ 1-12~ alquilamino, C~ 1-12~ alquil- ou arilamido, C~ 1-12~ alquil- ou arilcarbonila, C~ 1-12~ alquil- ou arilcarbóxi, C~ 1-12~ alquil- ou arilcarbamoíla, C~ 1-12~ alquila, C~ 2-12~ alquenila, C~ 2-12~ alquinila, arila, heteroarila, C~ 1-12~ alcóxi, arilóxi, azido, C~ 1-12~ alquil- ou ariltio, C~ 1-12~ alquil- ou aril-sulfonila, C~ 1-12~ alquil- ou aril-silila, C~ 1-12~ alquil ou arilfosforila e fosfato; a fim de formar um composto da fórmula (II), em que R, R', R~ 1~ e R~ 2~ são conforme definido com relação à fórmula (I); o referido método compreendendo o tratamento do composto da fórmula (I) com um catalisador de paládio(0) e um (difenilfosfino)~ n~C~ 1-6~ alcano, em que n é um número inteiro de 1 a 6. A invenção também proporciona método de fabricação de penciclovir e famciclovir usando-se essa reação de restruturação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9807116.0A GB9807116D0 (en) | 1998-04-02 | 1998-04-02 | Novel process |
| PCT/EP1999/002309 WO1999051604A2 (en) | 1998-04-02 | 1999-03-30 | Process for the production of purine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9908959A true BR9908959A (pt) | 2000-12-05 |
Family
ID=10829765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9908959-9A BR9908959A (pt) | 1998-04-02 | 1999-03-30 | Processo para a produição de derivados de purina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6437125B1 (pt) |
| EP (1) | EP1068210B1 (pt) |
| JP (1) | JP4459439B2 (pt) |
| KR (1) | KR100613812B1 (pt) |
| CN (1) | CN1125068C (pt) |
| AT (1) | ATE268332T1 (pt) |
| AU (1) | AU3605199A (pt) |
| BR (1) | BR9908959A (pt) |
| CA (1) | CA2323965A1 (pt) |
| DE (1) | DE69917765T2 (pt) |
| DK (1) | DK1068210T3 (pt) |
| ES (1) | ES2222702T3 (pt) |
| GB (1) | GB9807116D0 (pt) |
| IL (1) | IL138289A0 (pt) |
| PT (1) | PT1068210E (pt) |
| WO (1) | WO1999051604A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60202245T2 (de) | 2001-08-30 | 2005-09-01 | Ajinomoto Co., Inc. | Herstellungsmethode von Famciclovir und Herstellungs- bzw. Kristallisationsmethode eines entsprechenden Intermediates |
| CA2496684A1 (en) * | 2002-08-26 | 2004-03-04 | Teva Pharmaceutical Industries Ltd | Crystalline solid famciclovir forms i, ii, iii and preparation thereof |
| TW200613304A (en) * | 2004-05-18 | 2006-05-01 | Teva Pharma | Drying process for preparing crystalline solid famciclovir |
| GB2426247A (en) * | 2005-05-20 | 2006-11-22 | Arrow Int Ltd | Methods of preparing purine derivatives such as famciclovir |
| CN110386935A (zh) * | 2018-04-20 | 2019-10-29 | 重庆常捷医药有限公司 | 一种泛昔洛韦中间体的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5684153A (en) * | 1984-08-16 | 1997-11-04 | Beecham Group Plc | Process for the preparation of purine derivatives |
| EP0141927B1 (en) | 1983-08-18 | 1991-10-30 | Beecham Group Plc | Antiviral guanine derivatives |
| EP0182024B1 (en) | 1984-09-20 | 1991-04-03 | Beecham Group Plc | Purine derivatives and their pharmaceutical use |
| GB8817607D0 (en) * | 1988-07-23 | 1988-09-01 | Beecham Group Plc | Novel process |
| US5688948A (en) * | 1991-09-18 | 1997-11-18 | Ajinomoto Co., Inc. | Process for isomerizing acyclic nucleosides and process for separating purine nucleosides |
| GB9407698D0 (en) * | 1994-04-19 | 1994-06-15 | Smithkline Beecham Plc | Pharmaceuticals |
| EP0827960A1 (en) * | 1996-09-10 | 1998-03-11 | Ajinomoto Co., Inc. | Process for producing purine derivatives |
-
1998
- 1998-04-02 GB GBGB9807116.0A patent/GB9807116D0/en not_active Ceased
-
1999
- 1999-03-30 WO PCT/EP1999/002309 patent/WO1999051604A2/en not_active Ceased
- 1999-03-30 IL IL13828999A patent/IL138289A0/xx not_active IP Right Cessation
- 1999-03-30 EP EP19990917959 patent/EP1068210B1/en not_active Expired - Lifetime
- 1999-03-30 US US09/623,700 patent/US6437125B1/en not_active Expired - Lifetime
- 1999-03-30 ES ES99917959T patent/ES2222702T3/es not_active Expired - Lifetime
- 1999-03-30 AT AT99917959T patent/ATE268332T1/de not_active IP Right Cessation
- 1999-03-30 BR BR9908959-9A patent/BR9908959A/pt not_active Application Discontinuation
- 1999-03-30 PT PT99917959T patent/PT1068210E/pt unknown
- 1999-03-30 CN CN99804402A patent/CN1125068C/zh not_active Expired - Fee Related
- 1999-03-30 AU AU36051/99A patent/AU3605199A/en not_active Abandoned
- 1999-03-30 JP JP2000542325A patent/JP4459439B2/ja not_active Expired - Fee Related
- 1999-03-30 KR KR1020007010706A patent/KR100613812B1/ko not_active Expired - Fee Related
- 1999-03-30 DE DE69917765T patent/DE69917765T2/de not_active Expired - Fee Related
- 1999-03-30 DK DK99917959T patent/DK1068210T3/da active
- 1999-03-30 CA CA002323965A patent/CA2323965A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1068210B1 (en) | 2004-06-02 |
| KR100613812B1 (ko) | 2006-08-18 |
| US6437125B1 (en) | 2002-08-20 |
| AU3605199A (en) | 1999-10-25 |
| DE69917765T2 (de) | 2005-07-14 |
| IL138289A0 (en) | 2001-10-31 |
| ATE268332T1 (de) | 2004-06-15 |
| DE69917765D1 (de) | 2004-07-08 |
| ES2222702T3 (es) | 2005-02-01 |
| CA2323965A1 (en) | 1999-10-14 |
| JP2002510692A (ja) | 2002-04-09 |
| DK1068210T3 (da) | 2004-09-20 |
| PT1068210E (pt) | 2004-10-29 |
| WO1999051604A2 (en) | 1999-10-14 |
| CN1125068C (zh) | 2003-10-22 |
| WO1999051604A3 (en) | 2000-02-17 |
| JP4459439B2 (ja) | 2010-04-28 |
| HK1035896A1 (en) | 2001-12-14 |
| EP1068210A2 (en) | 2001-01-17 |
| CN1294591A (zh) | 2001-05-09 |
| GB9807116D0 (en) | 1998-06-03 |
| KR20010034701A (ko) | 2001-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Free format text: NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD (BM) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE A MATERIA REIVINDICADA NAO ATENDE AO REQUISITO DE ATIVIDADE INVENTIVA ( ART. 8O COMBINADO COM ART.13 DA LPI ) |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |