BR9815395A - Composições à base de nicotina e método de formulção das mesmas - Google Patents
Composições à base de nicotina e método de formulção das mesmasInfo
- Publication number
- BR9815395A BR9815395A BR9815395-1A BR9815395A BR9815395A BR 9815395 A BR9815395 A BR 9815395A BR 9815395 A BR9815395 A BR 9815395A BR 9815395 A BR9815395 A BR 9815395A
- Authority
- BR
- Brazil
- Prior art keywords
- precursors
- descendants
- liquid crystals
- dispersions
- nicotine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
<B>"COMPOSIçõES à BASE DE NICOTINA E MéTODOS DE FORMULAçãO DAS MESMAS"<D>. A presente invenção se refere a formulações de nicotina de lipídios polares em cristais líquidos e dispersões coloidais dos mesmos e precursores e descendentes dos mesmos, que quando em contato com um fluido do corpo e/ou pela influência da temperatura do corpo, são transformados em um cristal líquido ou numa mistura de cristais líquidos, que funciona como uma matriz de liberação controlada para nicotina, adequado. Por exemplo, para a interrupção do ato de fumar e/ou terapias de substituição. As composições divulgadas dos ditos cristais líquidos ou dispersões dos mesmos, seus precursores ou descendentes dos mesmos, contendo nicotina ou antiirritantes ou um analgésico local, ou quaisquer combinações destes, reduzem a irritação local da nicotina e mascaram seu teste. As rotas aplicáveis de dispositivos e administração incluem administração bucal, usando goma de mascar em que cristais líquidos e dispersões dos mesmos ou precursores e descendentes dos mesmos são formulados, adesivos géis e emplastros bucais, usando cristal líquido adesivo de muco, dispersões dos mesmos ou precursores dos mesmos, e spray para boca usando dispersão dos ditos cristais líquidos, seus precursores ou descendentes , spray e gel nasal usando os ditos cristais líquidos ou suas dispersões, seus precursores ou descendentes, e uso tópico, usando o dito cristal líquido ou seus precursores ou descendentes em emplastros e géis adesivos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9703458A SE9703458D0 (sv) | 1997-09-25 | 1997-09-25 | Nicotine compositions and methods of formulation thereof |
| PCT/SE1998/001632 WO1999015171A1 (en) | 1997-09-25 | 1998-09-15 | Nicotine compositions and methods of formulation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9815395A true BR9815395A (pt) | 2000-11-14 |
Family
ID=20408364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9815395-1A BR9815395A (pt) | 1997-09-25 | 1998-09-15 | Composições à base de nicotina e método de formulção das mesmas |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1023069B1 (pt) |
| JP (1) | JP2001517624A (pt) |
| KR (1) | KR20010024305A (pt) |
| CN (1) | CN1123343C (pt) |
| AT (1) | ATE253362T1 (pt) |
| AU (1) | AU733619B2 (pt) |
| BR (1) | BR9815395A (pt) |
| CA (1) | CA2304042A1 (pt) |
| DE (1) | DE69819548T2 (pt) |
| DK (1) | DK1023069T3 (pt) |
| EE (1) | EE200000154A (pt) |
| ES (1) | ES2210817T3 (pt) |
| FI (1) | FI20000692A7 (pt) |
| HU (1) | HUP0004802A3 (pt) |
| MX (1) | MXPA00002955A (pt) |
| NO (1) | NO20001540L (pt) |
| NZ (1) | NZ503408A (pt) |
| PT (1) | PT1023069E (pt) |
| RU (1) | RU2201747C2 (pt) |
| SE (1) | SE9703458D0 (pt) |
| WO (1) | WO1999015171A1 (pt) |
| ZA (1) | ZA988794B (pt) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6638621B2 (en) | 2000-08-16 | 2003-10-28 | Lyotropic Therapeutics, Inc. | Coated particles, methods of making and using |
| US8256433B2 (en) | 1999-07-16 | 2012-09-04 | Aradigm Corporation | Systems and methods for effecting cessation of tobacco use |
| US6799576B2 (en) | 1999-07-16 | 2004-10-05 | Aradigm Corporation | System for effecting smoking cessation |
| AT409219B (de) * | 1999-08-13 | 2002-06-25 | Red Bull Gmbh | Verwendung von nikotin zum herstellen von arzneimitteln |
| KR100381622B1 (ko) * | 2000-08-30 | 2003-04-26 | 디디에스텍주식회사 | 자극성을 줄인 염기성 약물의 구강 투여 조성물 |
| DE10057769A1 (de) * | 2000-11-22 | 2002-05-23 | Beiersdorf Ag | Haarpflegeprodukte mit einem Gehalt an dispersen Flüssigkristallen, welche kubische Phasen darstellen |
| SE0102197D0 (sv) * | 2001-06-20 | 2001-06-20 | Pharmacia Ab | New product and use and manufacture thereof |
| SE521512C2 (sv) | 2001-06-25 | 2003-11-11 | Niconovum Ab | Anordning för administrering av en substans till främre delen av en individs munhåla |
| WO2003082240A1 (de) * | 2002-03-30 | 2003-10-09 | Beisel Guenther | Zubereitung enthaltend fettsäure zur appetitminderung, sättigung und/oder gewichtsreduktion |
| US20040002520A1 (en) * | 2002-07-01 | 2004-01-01 | Soderlund Patrick L. | Composition and method for cessation of Nicotine cravings |
| KR100443722B1 (ko) * | 2002-09-26 | 2004-08-09 | 이용원 | 니코틴을 함유한 하드츄잉캔디 및 그의 제조방법 |
| ES2708552T3 (es) | 2002-12-20 | 2019-04-10 | Niconovum Ab | Método para la preparación de un material particulado que contiene nicotina con una celulosa cristalina (en particular MCC) |
| FR2851470B1 (fr) * | 2003-02-20 | 2007-11-16 | Besins Int Belgique | Composition pharmaceutique pour administration transdermique ou transmuqueuse |
| US9358296B2 (en) | 2003-02-24 | 2016-06-07 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
| US8992974B2 (en) * | 2003-02-24 | 2015-03-31 | Pharmaceuticals Productions, Inc. | Transmucosal drug delivery system |
| US10172810B2 (en) | 2003-02-24 | 2019-01-08 | Pharmaceutical Productions, Inc. | Transmucosal ketamine delivery composition |
| US9498454B2 (en) * | 2003-02-24 | 2016-11-22 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
| US9254294B2 (en) | 2003-02-24 | 2016-02-09 | Pharmaceutical Productions Inc. | Transmucosal hormone delivery system |
| RU2250052C2 (ru) * | 2003-05-16 | 2005-04-20 | Квасенков Олег Иванович | Способ производства некурительного табачного изделия |
| RU2250051C2 (ru) * | 2003-05-16 | 2005-04-20 | Квасенков Олег Иванович | Способ производства некурительного табачного изделия |
| RU2250057C2 (ru) * | 2003-05-16 | 2005-04-20 | Квасенков Олег Иванович | Способ производства некурительного табачного изделия |
| TW200514579A (en) * | 2003-07-24 | 2005-05-01 | Smithkline Beecham Corp | Orally dissolving films |
| GB0322033D0 (en) * | 2003-09-19 | 2003-10-22 | Camurus Ab | Composition |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| WO2005046363A2 (en) | 2003-11-07 | 2005-05-26 | U.S. Smokeless Tobacco Company | Tobacco compositions |
| US7125954B2 (en) | 2005-01-27 | 2006-10-24 | General Electric Company | Method for producing polyether polymers |
| US20080219935A1 (en) * | 2005-07-08 | 2008-09-11 | Sang-Hoon Kwak | Phase Transitive Breath Care Products |
| WO2007104573A2 (en) | 2006-03-16 | 2007-09-20 | Niconovum Ab | Improved snuff composition |
| CA2649149A1 (en) * | 2006-04-11 | 2007-10-25 | Koko Kosmetikvertrieb Gmbh & Co. Kg | Nanoparticle containing nicotine and/or cotinine, dispersions, and use thereof |
| US20080287507A1 (en) * | 2007-05-16 | 2008-11-20 | John Hedenstrom | Nicotine containing toiletry waters |
| GB2469792A (en) * | 2009-04-23 | 2010-11-03 | Calvin John Ross | Oil-based pharmaceutical formulation for sublingual delivery |
| GB2476471A (en) * | 2009-12-22 | 2011-06-29 | Norwich Pharma Technologies Ltd | Cotinine formulation for the treatment of obesity |
| US8846725B2 (en) * | 2011-01-24 | 2014-09-30 | Quadex Pharmaceuticals, Llc | Highly penetrating compositions and methods for treating pathogen-induced disordered tissues |
| CN102552405B (zh) * | 2012-03-21 | 2013-10-16 | 张伟 | 一种肛周术后麻醉镇痛的药物组合物的制备方法 |
| CN103040741B (zh) * | 2012-12-11 | 2014-11-05 | 中山大学 | 溶致液晶的前体混悬液及其制备方法 |
| WO2014135630A1 (en) * | 2013-03-07 | 2014-09-12 | Danmarks Tekniske Universitet | Nano-microdelivery systems for oromucosal delivery of an active ingredient |
| KR102490695B1 (ko) * | 2013-05-06 | 2023-01-19 | 쥴 랩스, 인크. | 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법 |
| WO2015090337A1 (en) * | 2013-12-20 | 2015-06-25 | Fertin Pharma A/S | Nicotine powder composition |
| JP6672258B2 (ja) * | 2014-04-08 | 2020-03-25 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | ニコチン製剤及びその作製方法 |
| GB201414919D0 (en) * | 2014-08-21 | 2014-10-08 | Corbitt Terence Simon | Formulations for transmucosal delivery |
| CN108472251B (zh) * | 2016-01-13 | 2022-02-01 | 株式会社 Lg 生活健康 | 口腔用制剂 |
| CN108323791B (zh) * | 2018-01-03 | 2021-02-12 | 云南中烟工业有限责任公司 | 一种尼古丁-氧化锌复合物、其制备方法及包含其的烟草制品 |
| MX2020010908A (es) * | 2018-04-16 | 2021-03-25 | Poviva Corp | Composiciones infundidas con compuestos de nicotina y metodos de uso de las mismas. |
| CN109125251B (zh) * | 2018-09-10 | 2021-08-13 | 武汉百纳礼康生物制药有限公司 | 一种包载蛋白类药物的温敏性液晶凝胶制剂及其制备方法 |
| KR102186704B1 (ko) * | 2019-02-18 | 2020-12-04 | (주)아이엠디팜 | 서방성 지질 전구 제제 및 이를 포함하는 지질 용액 형태의 서방성 주사용 약학 조성물 |
| LU101520B1 (en) * | 2019-12-02 | 2021-06-07 | Herrera Arturo Solis | (S)-3-[1-Methylpyrrolidin-2-yl]pyridine, analogues thereof, precursors thereof, or its derivatives, for the use as a pharmaceutical in form of a homogeneous, viscous, semi-solid topical medication and topical medication |
| LU101511B1 (en) * | 2019-12-02 | 2021-06-04 | Herrera Arturo Solis | (S)-3-[1-Methylpyrrolidin-2-yl]pyridine, analogues thereof, precursors thereof, or its derivatives, for the use as a pharmaceutical in form of a parenteral administration and a process for the preparation of an injectable substance |
| US12137723B2 (en) | 2019-12-09 | 2024-11-12 | Nicoventures Trading Limited | Oral products with active ingredient combinations |
| NL2031331B1 (en) | 2022-03-18 | 2023-09-29 | Plethora Therapeutics B V | Transmucosal delivery of a short-acting psychedelic compound |
| NL2031332B1 (en) | 2022-03-18 | 2023-09-29 | Plethora Therapeutics B V | Transmucosal delivery of psychoactive compounds |
| EP4570082A1 (en) * | 2023-12-15 | 2025-06-18 | Contraf-Nicotex-Tobacco GmbH | Oral product for delivery of nicotine comprising a nicotine salt of a fatty acid |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5371109A (en) * | 1986-07-01 | 1994-12-06 | Drilletten Ab | Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase |
| IL86170A (en) * | 1987-05-01 | 1992-12-01 | Elan Transdermal Ltd | Preparations and compositions comprising nicotine for percutaneous administration |
| US4908213A (en) * | 1989-02-21 | 1990-03-13 | Schering Corporation | Transdermal delivery of nicotine |
| GB2230439A (en) * | 1989-04-20 | 1990-10-24 | Alec Stanley Walter Shaw | Nicotine lozenges |
| CA2120359C (en) * | 1991-10-04 | 2000-12-26 | Tomas Landh | Particles, method of preparing said particles and uses thereof |
| EP0871489A1 (en) * | 1995-10-12 | 1998-10-21 | Gs Development Ab | A pharmaceutical composition for administration of an active substance to or through a skin or mucosal surface |
-
1997
- 1997-09-25 SE SE9703458A patent/SE9703458D0/xx unknown
-
1998
- 1998-09-15 KR KR1020007003204A patent/KR20010024305A/ko not_active Ceased
- 1998-09-15 RU RU2000110632/14A patent/RU2201747C2/ru not_active IP Right Cessation
- 1998-09-15 CA CA002304042A patent/CA2304042A1/en not_active Abandoned
- 1998-09-15 NZ NZ50340898A patent/NZ503408A/xx unknown
- 1998-09-15 MX MXPA00002955A patent/MXPA00002955A/es not_active IP Right Cessation
- 1998-09-15 AT AT98945685T patent/ATE253362T1/de not_active IP Right Cessation
- 1998-09-15 PT PT98945685T patent/PT1023069E/pt unknown
- 1998-09-15 DE DE69819548T patent/DE69819548T2/de not_active Expired - Fee Related
- 1998-09-15 AU AU92872/98A patent/AU733619B2/en not_active Ceased
- 1998-09-15 ES ES98945685T patent/ES2210817T3/es not_active Expired - Lifetime
- 1998-09-15 EP EP98945685A patent/EP1023069B1/en not_active Expired - Lifetime
- 1998-09-15 BR BR9815395-1A patent/BR9815395A/pt not_active IP Right Cessation
- 1998-09-15 EE EEP200000154A patent/EE200000154A/xx unknown
- 1998-09-15 HU HU0004802A patent/HUP0004802A3/hu unknown
- 1998-09-15 JP JP2000512540A patent/JP2001517624A/ja active Pending
- 1998-09-15 DK DK98945685T patent/DK1023069T3/da active
- 1998-09-15 WO PCT/SE1998/001632 patent/WO1999015171A1/en not_active Ceased
- 1998-09-15 CN CN98810645A patent/CN1123343C/zh not_active Expired - Fee Related
- 1998-09-25 ZA ZA988794A patent/ZA988794B/xx unknown
-
2000
- 2000-03-24 NO NO20001540A patent/NO20001540L/no not_active Application Discontinuation
- 2000-03-24 FI FI20000692A patent/FI20000692A7/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001517624A (ja) | 2001-10-09 |
| ATE253362T1 (de) | 2003-11-15 |
| EE200000154A (et) | 2001-02-15 |
| FI20000692L (fi) | 2000-03-24 |
| ZA988794B (en) | 1999-04-01 |
| WO1999015171A1 (en) | 1999-04-01 |
| CN1278174A (zh) | 2000-12-27 |
| DE69819548D1 (de) | 2003-12-11 |
| AU733619B2 (en) | 2001-05-17 |
| HUP0004802A2 (hu) | 2001-05-28 |
| NZ503408A (en) | 2004-12-24 |
| EP1023069B1 (en) | 2003-11-05 |
| KR20010024305A (ko) | 2001-03-26 |
| SE9703458D0 (sv) | 1997-09-25 |
| ES2210817T3 (es) | 2004-07-01 |
| CA2304042A1 (en) | 1999-04-01 |
| AU9287298A (en) | 1999-04-12 |
| MXPA00002955A (es) | 2002-04-24 |
| EP1023069A1 (en) | 2000-08-02 |
| NO20001540L (no) | 2000-05-25 |
| PT1023069E (pt) | 2004-02-27 |
| DE69819548T2 (de) | 2004-08-12 |
| RU2201747C2 (ru) | 2003-04-10 |
| DK1023069T3 (da) | 2004-03-08 |
| CN1123343C (zh) | 2003-10-08 |
| FI20000692A7 (fi) | 2000-03-24 |
| NO20001540D0 (no) | 2000-03-24 |
| HUP0004802A3 (en) | 2001-12-28 |
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