BR9814055B1 - composto, composição farmacêutica, uso do composto, e, processos para preparar e para produzir um composto. - Google Patents
composto, composição farmacêutica, uso do composto, e, processos para preparar e para produzir um composto.Info
- Publication number
- BR9814055B1 BR9814055B1 BRPI9814055-8A BR9814055A BR9814055B1 BR 9814055 B1 BR9814055 B1 BR 9814055B1 BR 9814055 A BR9814055 A BR 9814055A BR 9814055 B1 BR9814055 B1 BR 9814055B1
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- processes
- producing
- pharmaceutical composition
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- QDEVEJYEXBFIJD-UHFFFAOYSA-N triazolo[4,5-i][1]benzazepine Chemical class C1=CC2=CC=CC=NC2=C2C1=NN=N2 QDEVEJYEXBFIJD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26461197 | 1997-09-29 | ||
| JP5206398 | 1998-03-04 | ||
| PCT/JP1998/004363 WO1999016770A1 (en) | 1997-09-29 | 1998-09-29 | Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9814055A BR9814055A (pt) | 2000-09-26 |
| BR9814055B1 true BR9814055B1 (pt) | 2009-05-05 |
Family
ID=26392670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9814055-8A BR9814055B1 (pt) | 1997-09-29 | 1998-09-29 | composto, composição farmacêutica, uso do composto, e, processos para preparar e para produzir um composto. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US6372735B1 (pt) |
| EP (1) | EP1026167B1 (pt) |
| JP (1) | JP3188482B2 (pt) |
| KR (1) | KR100389140B1 (pt) |
| CN (2) | CN1155599C (pt) |
| AT (1) | ATE233764T1 (pt) |
| AU (1) | AU744636B2 (pt) |
| BR (1) | BR9814055B1 (pt) |
| CA (1) | CA2305307C (pt) |
| DE (1) | DE69811930T2 (pt) |
| DK (1) | DK1026167T3 (pt) |
| ES (1) | ES2191963T3 (pt) |
| HU (1) | HUP0004020A3 (pt) |
| ID (1) | ID24101A (pt) |
| IL (1) | IL135303A0 (pt) |
| NO (2) | NO319542B1 (pt) |
| NZ (1) | NZ503601A (pt) |
| PL (1) | PL339544A1 (pt) |
| PT (1) | PT1026167E (pt) |
| RU (1) | RU2198885C2 (pt) |
| SK (1) | SK283869B6 (pt) |
| TR (1) | TR200000808T2 (pt) |
| TW (1) | TW510902B (pt) |
| WO (1) | WO1999016770A1 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE469902T1 (de) * | 2001-12-26 | 2010-06-15 | Meiji Seika Kaisha | Amorphe substanz eines tricyclischen triazolobenzazepinderivats |
| JP4434747B2 (ja) * | 2002-02-01 | 2010-03-17 | 明治製菓株式会社 | １，２，３−トリアゾール化合物の製造法 |
| PL374860A1 (en) | 2002-07-09 | 2005-11-14 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| PL375230A1 (en) | 2002-07-09 | 2005-11-28 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| JPWO2004113343A1 (ja) * | 2003-06-19 | 2006-08-31 | 明治製菓株式会社 | 三環性トリアゾロベンゾアゼピン誘導体の新規結晶性物質 |
| JPWO2004113451A1 (ja) * | 2003-06-20 | 2006-08-17 | 明治製菓株式会社 | 難溶性物質と水溶性高分子との共沈物およびその製造方法 |
| ES2299080T3 (es) | 2004-05-14 | 2008-05-16 | Millennium Pharmaceuticals, Inc. | Compuestos y metodos para inhibir la progresion mitotica mediante la inhibicion de quinasas aurora. |
| BRPI0708448A2 (pt) * | 2006-03-02 | 2011-06-07 | Meiji Seika Kaisha | composição farmacêutica, método para a profilaxia ou tratamento de doenças oftálmicas alérgicas ou doenças nasais alérgicas, e, uso de um composto |
| EP2094711B8 (de) * | 2006-09-25 | 2018-03-28 | Forschungsverbund Berlin e.V. | Strukturmimetika prolinreicher peptide und ihre pharmazeutische verwendung |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| CN101903027B (zh) * | 2007-12-18 | 2013-06-12 | 明治制果药业株式会社 | 用于炎症性肠疾病的预防剂或治疗剂 |
| WO2010074724A1 (en) | 2008-12-22 | 2010-07-01 | Millennium Pharmaceuticals, Inc. | Combination of aurora kinase inhibitors and anti-cd20 antibodies |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
| ES2768295T3 (es) | 2010-01-07 | 2020-06-22 | Alkermes Pharma Ireland Ltd | Profármacos de compuestos heteroaromáticos |
| US8653064B2 (en) | 2010-02-19 | 2014-02-18 | Millennium Pharmaceuticals, Inc. | Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-D][2]benzazepin-2-yl]amino}-2-methoxybenzoate |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| US9724354B2 (en) | 2013-03-22 | 2017-08-08 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase |
| JP2018524292A (ja) | 2015-07-21 | 2018-08-30 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | オーロラキナーゼインヒビターと化学療法剤の投与 |
| WO2019133770A2 (en) * | 2017-12-29 | 2019-07-04 | Biomarin Pharmaceutical Inc. | Glycolate oxidase inhibitors for the treatment of disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5488134A (en) | 1993-04-16 | 1996-01-30 | Shionogi & Co., Ltd. | Preparation of compounds of lignan series |
| DE69427023T2 (de) * | 1993-12-28 | 2001-10-31 | Meiji Seika K.K., Tokio/Tokyo | Tricyclische benzazepin-und benzothiazepin derivate |
| CN1066148C (zh) | 1995-06-15 | 2001-05-23 | 明治制果株式会社 | 三环性苯并氮杂䓬化合物 |
| CN1084747C (zh) * | 1996-03-08 | 2002-05-15 | 曾尼卡有限公司 | 作为神经活性剂的吡咯并苯并氮杂䓬衍生物 |
| US20070059533A1 (en) * | 2005-09-12 | 2007-03-15 | Burdette Steven R | Thermal reflow of glass and fused silica body |
-
1998
- 1998-09-29 CN CNB98810735XA patent/CN1155599C/zh not_active Expired - Fee Related
- 1998-09-29 TR TR2000/00808T patent/TR200000808T2/xx unknown
- 1998-09-29 US US09/509,494 patent/US6372735B1/en not_active Expired - Lifetime
- 1998-09-29 AU AU91869/98A patent/AU744636B2/en not_active Ceased
- 1998-09-29 IL IL13530398A patent/IL135303A0/xx unknown
- 1998-09-29 DE DE69811930T patent/DE69811930T2/de not_active Expired - Lifetime
- 1998-09-29 BR BRPI9814055-8A patent/BR9814055B1/pt not_active IP Right Cessation
- 1998-09-29 PT PT98944289T patent/PT1026167E/pt unknown
- 1998-09-29 ES ES98944289T patent/ES2191963T3/es not_active Expired - Lifetime
- 1998-09-29 WO PCT/JP1998/004363 patent/WO1999016770A1/ja not_active Ceased
- 1998-09-29 AT AT98944289T patent/ATE233764T1/de active
- 1998-09-29 HU HU0004020A patent/HUP0004020A3/hu unknown
- 1998-09-29 JP JP51996999A patent/JP3188482B2/ja not_active Expired - Fee Related
- 1998-09-29 ID IDW20000808A patent/ID24101A/id unknown
- 1998-09-29 CN CNB2003101047539A patent/CN1312135C/zh not_active Expired - Fee Related
- 1998-09-29 NZ NZ503601A patent/NZ503601A/en unknown
- 1998-09-29 RU RU2000111517/04A patent/RU2198885C2/ru not_active IP Right Cessation
- 1998-09-29 KR KR10-2000-7003362A patent/KR100389140B1/ko not_active Expired - Fee Related
- 1998-09-29 DK DK98944289T patent/DK1026167T3/da active
- 1998-09-29 EP EP98944289A patent/EP1026167B1/en not_active Expired - Lifetime
- 1998-09-29 CA CA002305307A patent/CA2305307C/en not_active Expired - Fee Related
- 1998-09-29 PL PL98339544A patent/PL339544A1/xx unknown
- 1998-09-29 SK SK425-2000A patent/SK283869B6/sk unknown
- 1998-09-29 TW TW087116198A patent/TW510902B/zh not_active IP Right Cessation
-
2000
- 2000-03-23 NO NO20001500A patent/NO319542B1/no unknown
-
2002
- 2002-02-13 US US10/073,326 patent/US7022860B2/en not_active Expired - Fee Related
-
2004
- 2004-09-08 NO NO20043765A patent/NO20043765L/no not_active Application Discontinuation
-
2005
- 2005-11-09 US US11/269,828 patent/US7238812B2/en not_active Expired - Fee Related
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DE INT.CL.8: C07D 487/04, C07F 9/6561, A61K 31/55, C07D 249/04, C07C 69/738, C07C 59/76, A61P 37/08 Ipc: C07D 487/04 (2007.01), C07F 9/6561 (2007.01), A61K |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/07/2009, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B25D | Requested change of name of applicant approved |
Owner name: MEIJI SEIKA PHARMA CO., LTD. (JP) Free format text: NOME ALTERADO DE: MEIJI SEIKA KAISHA, LTD. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |
|
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2325 DE 28-07-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |