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BR9711079A - Imunoglobina humanizada reagente com integrina e métodos para sua obtenção e para seu uso. - Google Patents

Imunoglobina humanizada reagente com integrina e métodos para sua obtenção e para seu uso.

Info

Publication number
BR9711079A
BR9711079A BR9711079-5A BR9711079A BR9711079A BR 9711079 A BR9711079 A BR 9711079A BR 9711079 A BR9711079 A BR 9711079A BR 9711079 A BR9711079 A BR 9711079A
Authority
BR
Brazil
Prior art keywords
present
humanized
immunoglobulin
integrin
human
Prior art date
Application number
BR9711079-5A
Other languages
English (en)
Other versions
BRPI9711079B8 (pt
BRPI9711079B1 (pt
Inventor
Paul D Ponath
Douglas J Ringler
S Tarran Jones
Walter Newman
Jose Saldanha
Mary M Bendig
Original Assignee
Leukosite Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24814673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9711079(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Leukosite Inc filed Critical Leukosite Inc
Publication of BR9711079A publication Critical patent/BR9711079A/pt
Publication of BRPI9711079B1 publication Critical patent/BRPI9711079B1/pt
Publication of BRPI9711079B8 publication Critical patent/BRPI9711079B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"IMUNOGLOBULINA HUMANIZADA REAGENTE COM INTEGRINA <244>4<225>7" E MéTODOS PARA SUA OBTENçãO E PARA SEU USO". A presente invenção relaciona-se a imunoglobulinas humanizadas tendo especificidade de ligação em relação a integrina <244>4<225>7, compreendendo uma região de ligação a antígeno de origem não humana (por exemplo, de roedor) e pelo menos uma porção de uma imunoglubulina de origem humana (por exemplo, uma região de estrutura humana, uma região constante humana). Em uma incorporação, a imunoglobulina humanizada pode competir com Act-1 murino em relação à ligação a integrina <244>4<225>7 humana. Em uma incorporação preferida, a região de ligação a antígeno da imunoglobulina humanizada compreende cada uma das regiões determinadoras de complementaridade das cadeias leve e pesada do anticorpo Act-1 murino. A presente invenção relaciona-se, ademais, a uma cadeia leve ou cadeia pesada de imunoglobulina humanizada, a ácidos nucléicos isolados compreendendo uma seq³ência codificando uma imunoglobulina ou cadeia de imunoglobulina humanizada da presente invenção (por exemplo, um anticorpo de cadeia única), construções compreendendo um ácido nucléico da presente invenção, e células hospedeiras compreendendo um ácido nucléico da presente invenção, úteis em um método para preparar uma imunoglobulina humanizada. As imunoglobulinas humanizadas podem ser usadas em aplicações de diagnóstico e terapêutica em seres humanos, por exemplo, para controlar a infiltração (incluindo recrutamento e/ou acumulação de linfócitos em tecido mucosal.
BRPI9711079-5A 1996-08-15 1997-08-06 Humanized immunoglobulin or antigen-binding fragment thereof, isolated nucleic acid, expression vector, humanized heavy chain immunoglobulin or antigen-binding fragment thereof, method for preparing a humanized light chain immunoglobulin, pharmaceutical composition and use of an immunoglobulin humanized or antigen-binding fragment thereof BRPI9711079B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/700,737 1996-08-15
US08/700,737 US7147851B1 (en) 1996-08-15 1996-08-15 Humanized immunoglobulin reactive with α4β7 integrin
PCT/US1997/013884 WO1998006248A2 (en) 1996-08-15 1997-08-06 HUMANIZED IMMUNOGLOBULIN REACTIVE WITH α4β7 INTEGRIN

Publications (3)

Publication Number Publication Date
BR9711079A true BR9711079A (pt) 2000-06-06
BRPI9711079B1 BRPI9711079B1 (pt) 2017-06-20
BRPI9711079B8 BRPI9711079B8 (pt) 2021-05-25

Family

ID=24814673

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9711079-5A BRPI9711079B1 (pt) 1996-08-15 1997-08-06 Humanized immunoglobulin or antigen-binding fragment thereof, isolated nucleic acid, expression vector, humanized heavy chain immunoglobulin or antigen-binding fragment thereof, method for preparing a humanized light chain immunoglobulin, pharmaceutical composition and use of an immunoglobulin humanized or antigen-binding fragment thereof

Country Status (19)

Country Link
US (3) US7147851B1 (pt)
EP (2) EP1710314A1 (pt)
JP (3) JP4171071B2 (pt)
CN (1) CN100406562C (pt)
AT (1) ATE321788T1 (pt)
AU (1) AU730326C (pt)
BE (1) BE2014C068I2 (pt)
BR (1) BRPI9711079B1 (pt)
CA (1) CA2263106C (pt)
DE (1) DE69735596T3 (pt)
DK (1) DK0918797T4 (pt)
ES (1) ES2262186T5 (pt)
IL (3) IL128052A0 (pt)
LT (1) LTC0918797I2 (pt)
LU (1) LU92596I2 (pt)
NZ (1) NZ334226A (pt)
PT (1) PT918797E (pt)
SI (1) SI0918797T2 (pt)
WO (1) WO1998006248A2 (pt)

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WO1998006248A3 (en) 1998-05-07
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DE69735596D1 (de) 2006-05-18
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