[go: up one dir, main page]

BR9708171A - Uso de derivados de 4-fenil-3,6-di-hidro-2h-piridila como bloqueadores de subtipo de receptor nmda - Google Patents

Uso de derivados de 4-fenil-3,6-di-hidro-2h-piridila como bloqueadores de subtipo de receptor nmda

Info

Publication number
BR9708171A
BR9708171A BR9708171A BR9708171A BR9708171A BR 9708171 A BR9708171 A BR 9708171A BR 9708171 A BR9708171 A BR 9708171A BR 9708171 A BR9708171 A BR 9708171A BR 9708171 A BR9708171 A BR 9708171A
Authority
BR
Brazil
Prior art keywords
nmda receptor
receptor subtype
hydrogen
dihydro
phenyl
Prior art date
Application number
BR9708171A
Other languages
English (en)
Inventor
Anne Bourson
Guenther Fischer
Neidhart Marie-Paule Heitz
Vincent Mutel
Gerhard Trube
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR9708171A publication Critical patent/BR9708171A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR9708171A 1996-03-08 1997-02-27 Uso de derivados de 4-fenil-3,6-di-hidro-2h-piridila como bloqueadores de subtipo de receptor nmda BR9708171A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96103636 1996-03-08
PCT/EP1997/000951 WO1997032581A1 (en) 1996-03-08 1997-02-27 Use of 4-phenyl-3,6-dihydro-2h-pyridyl derivatives as nmda receptor subtype blockers

Publications (1)

Publication Number Publication Date
BR9708171A true BR9708171A (pt) 1999-07-27

Family

ID=8222541

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9708171A BR9708171A (pt) 1996-03-08 1997-02-27 Uso de derivados de 4-fenil-3,6-di-hidro-2h-piridila como bloqueadores de subtipo de receptor nmda

Country Status (15)

Country Link
US (1) US5962472A (pt)
EP (1) EP0885004B1 (pt)
JP (1) JP3248917B2 (pt)
KR (1) KR100352358B1 (pt)
CN (1) CN1131031C (pt)
AT (1) ATE216883T1 (pt)
AU (1) AU717140B2 (pt)
BR (1) BR9708171A (pt)
CA (1) CA2248134A1 (pt)
DE (1) DE69712325T2 (pt)
DK (1) DK0885004T3 (pt)
ES (1) ES2174220T3 (pt)
PT (1) PT885004E (pt)
TR (1) TR199801774T2 (pt)
WO (1) WO1997032581A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
JP2005506292A (ja) * 2001-03-08 2005-03-03 エモリー　ユニバーシティ ｐＨに依存するＮＭＤＡレセプターアンタゴニスト
US6951875B2 (en) 2001-10-29 2005-10-04 Hoffmann-La Roche Inc. Conjugated aromatic compounds with a pyridine substituent
US7005432B2 (en) * 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
CA2547283C (en) * 2003-11-26 2010-11-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors
EP2170334B1 (en) 2007-06-29 2021-03-17 Emory University Nmda receptor antagonists for neuroprotection
KR20100135847A (ko) * 2008-03-27 2010-12-27 에보텍 뉴로사이언시즈 게엠베하 Ｎｍｄａ ｎｒ２ｂ―서브타입 선택적 길항제를 사용한 질병 치료 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH507239A (de) * 1968-12-24 1971-05-15 Hoffmann La Roche Verfahren zur Herstellung von aromatischen Äthern
CH558354A (de) * 1970-06-17 1975-01-31 Hoffmann La Roche Verfahren zur herstellung von aromatischen aethern.
US3879405A (en) * 1970-06-19 1975-04-22 Hoffmann La Roche Tetrahydropyridine derivatives
CH547802A (de) * 1970-06-19 1974-04-11 Hoffmann La Roche Verfahren zur herstellung von tetrahydropyridinderivaten.
US5149817A (en) * 1990-03-05 1992-09-22 Shionogi & Co., Ltd. Teirahydropyridine derivatives
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE4325885A1 (de) * 1993-08-02 1995-02-09 Basf Ag Elektrolumineszierende Anordnung
DE4410822A1 (de) * 1994-03-24 1995-09-28 Schering Ag Neue Piperidin-Derivate
US5698565A (en) * 1995-06-09 1997-12-16 Hoffmann-La Roche Inc. Use of phenoxy-pyridine derivatives

Also Published As

Publication number Publication date
KR19990087505A (ko) 1999-12-27
DK0885004T3 (da) 2002-08-19
PT885004E (pt) 2002-08-30
EP0885004B1 (en) 2002-05-02
EP0885004A1 (en) 1998-12-23
JP3248917B2 (ja) 2002-01-21
ATE216883T1 (de) 2002-05-15
DE69712325D1 (de) 2002-06-06
ES2174220T3 (es) 2002-11-01
CN1213304A (zh) 1999-04-07
AU1878297A (en) 1997-09-22
JP2000507542A (ja) 2000-06-20
CN1131031C (zh) 2003-12-17
DE69712325T2 (de) 2002-11-28
WO1997032581A1 (en) 1997-09-12
KR100352358B1 (ko) 2003-03-10
AU717140B2 (en) 2000-03-16
CA2248134A1 (en) 1997-09-12
TR199801774T2 (xx) 1998-12-21
US5962472A (en) 1999-10-05

Similar Documents

Publication Publication Date Title
BR9812046A (pt) Compostos, processos para a preperação do composto e para tratar um paciente humano ou animal, composição farmacêutica, e, uso de um composto
MY118163A (en) Aryl fused azapolycyclic compounds
MY138352A (en) Benzothiazole derivatives
ES2141137T3 (es) Agentes terapeuticos para la enfermedad de parkinson.
MY117896A (en) Quinazoline derivatives
DK1173433T3 (da) Cyanopyrroler som progesteronreceptoragonister
ATE139233T1 (de) Annelierte thiophen-derivate, ihre herstellung und verwendung
WO1999024022A3 (en) Isoquinoline derivatives for treating disorders associated with 5ht7 receptors
DE60001586D1 (de) Diphenyl-piperidin derivate
DK0779284T3 (da) Hidtil ukendte 2-naphtanamidderivater og terapeutiske anvendelser heraf som agonister af D3-receptorer
AR015446A1 (es) Antagonistas de receptores de vitronectina, composicion farmaceutica que los contiene, procedimiento para su preparacion, su uso para la elaboracion de unmedicamento y compuestos intermediarios
EA199801028A1 (ru) Применение производных п-аминофенола для проготовления фармацевтических композиций, используемых при лечении нейродегенеративных заболеваний
BR9708171A (pt) Uso de derivados de 4-fenil-3,6-di-hidro-2h-piridila como bloqueadores de subtipo de receptor nmda
MY111474A (en) Pyrimidone derivatives and analogs in the treatment of asthma or certain skin disorders.
NO953353L (no) Xantinderivater som adenosin-A -reseptorantagonister
PT99864A (pt) Processo para a preparacao de novas composicoes farmaceuticas contendo antagonistas de receptor de quisqualato
BR9812404A (pt) Combinação de um antagonista de endotelina, preparação farmacêutica, processo para preparar uma preparação farmacêutica, e , uso de uma combinação de um bloqueador de beta receptor e de um antagonista de endotelina
SE9603285D0 (sv) New compounds
SE9401087D0 (sv) New prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
NO950177L (no) Farmakologisk aktive erivater
FR2618435B1 (fr) Derives de benzimidazole, leur preparation et leur application en therapeutique
YU61096A (sh) Novi intermedijari, njihova primena u sintezi n,n'-premoštenih bisindolilmaleimida i farmaceutske formulacije
IT1260444B (it) Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
TR199900013T2 (xx) Yeni bile�ikler.
NO992316L (no) Benzensulfonamidderivater og legemidler inneholdende disse

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, COM BASE NOS ARTIGOS 8 E 11 DA LPI E DADO COMO CONCLUIDO O EXAME.

B12B Appeal against refusal [chapter 12.2 patent gazette]