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BR9611412A - Processo para a sìntese de componentes correlatos a curcumina. - Google Patents

Processo para a sìntese de componentes correlatos a curcumina.

Info

Publication number
BR9611412A
BR9611412A BR9611412-6A BR9611412A BR9611412A BR 9611412 A BR9611412 A BR 9611412A BR 9611412 A BR9611412 A BR 9611412A BR 9611412 A BR9611412 A BR 9611412A
Authority
BR
Brazil
Prior art keywords
curcumin
synthesis
components related
solvent
curcumina
Prior art date
Application number
BR9611412-6A
Other languages
English (en)
Inventor
Harry Mark Krackov
Original Assignee
Geneprint Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneprint Inc filed Critical Geneprint Inc
Publication of BR9611412A publication Critical patent/BR9611412A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Relatório Descritivo da Patente de Invenção para <B>"PROCESSO PARA SìNTESE DE COMPONENTES CORRELATOS A CURCUMINA"<D>. A invenção é direcionada a um processo para a síntese da curcumina e dos componentes correlatos a curcumina, reagindo a forma enol de uma dicetona 2,4 com um aldeído mono-carbocíclico na presença de um catalisador amina orgânico. Os reagentes são dissolvidos em um solvente orgânico aprótico altamente polar. O produto correlato a curcumina é recoberto numa forma cristalina através da precipitação da massa de reação da recristalização do solvente.
BR9611412-6A 1995-11-03 1996-11-01 Processo para a sìntese de componentes correlatos a curcumina. BR9611412A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/552,904 US5679864A (en) 1995-11-03 1995-11-03 Process for the synthesis of curcumin-related compounds
PCT/US1996/017524 WO1997016403A1 (en) 1995-11-03 1996-11-01 Process for the synthesis of curcumin-related compounds

Publications (1)

Publication Number Publication Date
BR9611412A true BR9611412A (pt) 1999-12-28

Family

ID=24207300

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9611412-6A BR9611412A (pt) 1995-11-03 1996-11-01 Processo para a sìntese de componentes correlatos a curcumina.

Country Status (16)

Country Link
US (1) US5679864A (pt)
EP (1) EP0861223B1 (pt)
JP (1) JP3346576B2 (pt)
KR (1) KR19990067279A (pt)
AT (1) ATE256652T1 (pt)
AU (1) AU7551096A (pt)
BR (1) BR9611412A (pt)
CA (1) CA2236600A1 (pt)
DE (1) DE69631155T2 (pt)
DK (1) DK0861223T3 (pt)
ES (1) ES2213183T3 (pt)
HU (1) HUP9901894A2 (pt)
MX (1) MX9803546A (pt)
NO (1) NO981974L (pt)
PL (1) PL326452A1 (pt)
WO (1) WO1997016403A1 (pt)

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WO2000076492A1 (en) * 1999-06-15 2000-12-21 Nutri-Logics, Inc. Nutrient formulations for disease reduction, and related treatment and component screening methods
US20030149113A1 (en) * 2001-10-12 2003-08-07 Caplan Michael J. Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
US20030236300A1 (en) * 1999-10-27 2003-12-25 Yale University Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
DE10029770A1 (de) * 2000-06-16 2001-12-20 Transmit Technologietransfer Verwendung von Curcuminen zur Behandlung von soliden Tumoren,insbesondere von Hirntumoren
WO2002083614A1 (en) * 2001-04-18 2002-10-24 Laila, Impex Novel polyhydroxy curcumins having antioxidant activity
US7355081B2 (en) 2002-04-17 2008-04-08 The University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
US6790979B2 (en) * 2002-04-17 2004-09-14 University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
AU2002314566A1 (en) * 2002-06-17 2003-12-31 Ho-Jeong Kwon Novel curcumin derivatives
DE102005008262A1 (de) * 2005-02-22 2006-08-24 Basf Ag Verfahren zur Herstellung von Curcumin
EP1999097B1 (en) * 2006-03-29 2011-12-21 DSM IP Assets B.V. Curcumin synthesis
EP2037762A4 (en) * 2006-06-05 2009-07-08 Darrick S H L Kim PROCESS FOR THE PREPARATION OF PURE CURCUMIN
US7507864B2 (en) * 2006-08-01 2009-03-24 Salisbury University Method for the synthesis of curcumin analogues
US8962674B2 (en) 2006-11-30 2015-02-24 Tokyo Institute Of Technology Curcumin derivative
US9000222B2 (en) 2007-01-08 2015-04-07 Androscience Corporation Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US8710272B2 (en) 2007-01-08 2014-04-29 Androscience Corporation Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
KR101563370B1 (ko) 2007-01-08 2015-10-26 앤드로사이언스 코포레이션 (치환된 페닐)-프로페날 잔기를 갖는 화합물, 이의 유도체, 생물학적 활성, 및 이의 용도
EP2749552B1 (en) * 2007-04-17 2015-11-18 Codman & Shurtleff, Inc. Curcumin-resveratrol hybrids
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
EP2175726A4 (en) 2007-07-31 2011-01-05 Androscience Corp COMPOSITIONS WITH ANDROGEN RECEPTOR DERIVATIVES AND METHOD FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF SKIN DISEASES OR HAIR LOSS
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US7985776B2 (en) * 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
US7723515B1 (en) * 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
WO2010132815A1 (en) 2009-05-15 2010-11-18 The Research Foundation Of State University Of New York Curcumin analogues as zinc chelators and their uses
US9393198B2 (en) * 2010-03-22 2016-07-19 Signpath Pharma Inc. Intravenous curcumin and derivatives for treatment of neurodegenerative and stress disorders
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
EP2714011B1 (en) 2011-06-03 2018-01-31 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
EP3326616B1 (en) 2011-06-03 2021-07-28 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
US10449193B2 (en) 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
WO2013167770A1 (es) 2012-05-08 2013-11-14 Asac Compañía De Biotecnología E Investigacion Sa Procedimiento para la síntesis de curcumina
US9170257B2 (en) 2012-06-14 2015-10-27 Signpath Pharma Inc. Method and system for measuring the pharmacokinetics of liposomal curcumin and its metabolite tetrahydrocurcumin
CA2882978A1 (en) 2012-08-31 2014-03-06 University Of North Texas Health Science Center Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy
JP6895252B2 (ja) 2013-12-18 2021-06-30 サインパス ファルマ, インク.Signpath Pharma, Inc. 心筋ｉｋｒチャネルの薬剤誘発性阻害のリポソームによる軽減
WO2017164172A1 (ja) 2016-03-22 2017-09-28 国立研究開発法人科学技術振興機構 クルクミンホウ素錯体及びこれを含有する医薬
AU2017257496B2 (en) 2016-04-27 2020-05-07 Signpath Pharma, Inc. Prevention of drug-induced atrio-ventricular block
CN110551026B (zh) * 2018-06-04 2022-02-15 永胜光学股份有限公司 改质姜黄素及其制备方法
US11434189B1 (en) * 2021-10-20 2022-09-06 I-Mei Foods Co., Ltd. Method for isolating curcuminoids from turmeric rhizome

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DE859145C (de) * 1944-04-22 1952-12-11 Hoechst Ag Verfahren zur Herstellung von symmetrischen 1, 3-Diketonen
NL255427A (pt) * 1959-08-31
DE1280849B (de) * 1967-06-10 1968-10-24 Ludwig Heumann & Co Chem Pharm Verfahren zur Herstellung von Curcumin aus Vanillin und Acetylaceton
DE1282642B (de) * 1967-12-09 1968-11-14 Ludwig Heumann & Co Chemisch P Verfahren zur Herstellung von Curcumin aus Vanillin und Acetylaceton

Also Published As

Publication number Publication date
EP0861223B1 (en) 2003-12-17
US5679864A (en) 1997-10-21
KR19990067279A (ko) 1999-08-16
NO981974D0 (no) 1998-04-30
DE69631155D1 (de) 2004-01-29
MX9803546A (es) 1998-11-29
DE69631155T2 (de) 2004-09-02
JPH11502232A (ja) 1999-02-23
AU7551096A (en) 1997-05-22
CA2236600A1 (en) 1997-05-09
ES2213183T3 (es) 2004-08-16
DK0861223T3 (da) 2004-04-05
PL326452A1 (en) 1998-09-28
JP3346576B2 (ja) 2002-11-18
NO981974L (no) 1998-06-03
EP0861223A1 (en) 1998-09-02
HUP9901894A2 (hu) 1999-09-28
WO1997016403A1 (en) 1997-05-09
ATE256652T1 (de) 2004-01-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A, 4A, 5A, 6A, 7A, 8A, 9A, 10A, 11A, 12A, 13A E 14A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.