[go: up one dir, main page]

NO981974L - FremgangsmÕte for syntesen av curcuminrelaterte forbindelser - Google Patents

FremgangsmÕte for syntesen av curcuminrelaterte forbindelser

Info

Publication number
NO981974L
NO981974L NO981974A NO981974A NO981974L NO 981974 L NO981974 L NO 981974L NO 981974 A NO981974 A NO 981974A NO 981974 A NO981974 A NO 981974A NO 981974 L NO981974 L NO 981974L
Authority
NO
Norway
Prior art keywords
curcumin
synthesis
related compounds
diketone
reactants
Prior art date
Application number
NO981974A
Other languages
English (en)
Other versions
NO981974D0 (no
Inventor
Mark Harry Krackov
Harold Edward Bellis
Original Assignee
Geneprint Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneprint Inc filed Critical Geneprint Inc
Publication of NO981974D0 publication Critical patent/NO981974D0/no
Publication of NO981974L publication Critical patent/NO981974L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Foreliggende oppfinnelse er rettet mot en fremgangsmåte for syntesen av curcumin og curcuminrelaterte forbindelser ved reagering av enolformen av et 2,4-diketon med et monokarboksylsyrealdehyd i nærvær av en organisk aminkatalysator. Reaktantene blir oppløst i et sterkt polart, aprotisk organisk oppløsningsmiddel. Det curcuminrelaterte produktet blir gjenvunnet i krystallinsk form ved utfelling fra reaksjonsmassen og opp- løsningsmiddelrekrystallisering.
NO981974A 1995-11-03 1998-04-30 FremgangsmÕte for syntesen av curcuminrelaterte forbindelser NO981974L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/552,904 US5679864A (en) 1995-11-03 1995-11-03 Process for the synthesis of curcumin-related compounds
PCT/US1996/017524 WO1997016403A1 (en) 1995-11-03 1996-11-01 Process for the synthesis of curcumin-related compounds

Publications (2)

Publication Number Publication Date
NO981974D0 NO981974D0 (no) 1998-04-30
NO981974L true NO981974L (no) 1998-06-03

Family

ID=24207300

Family Applications (1)

Application Number Title Priority Date Filing Date
NO981974A NO981974L (no) 1995-11-03 1998-04-30 FremgangsmÕte for syntesen av curcuminrelaterte forbindelser

Country Status (16)

Country Link
US (1) US5679864A (no)
EP (1) EP0861223B1 (no)
JP (1) JP3346576B2 (no)
KR (1) KR19990067279A (no)
AT (1) ATE256652T1 (no)
AU (1) AU7551096A (no)
BR (1) BR9611412A (no)
CA (1) CA2236600A1 (no)
DE (1) DE69631155T2 (no)
DK (1) DK0861223T3 (no)
ES (1) ES2213183T3 (no)
HU (1) HUP9901894A2 (no)
MX (1) MX9803546A (no)
NO (1) NO981974L (no)
PL (1) PL326452A1 (no)
WO (1) WO1997016403A1 (no)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076492A1 (en) * 1999-06-15 2000-12-21 Nutri-Logics, Inc. Nutrient formulations for disease reduction, and related treatment and component screening methods
US20030236300A1 (en) * 1999-10-27 2003-12-25 Yale University Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
US20030149113A1 (en) * 2001-10-12 2003-08-07 Caplan Michael J. Conductance of improperly folded proteins through the secretory pathway and related methods for treating disease
DE10029770A1 (de) * 2000-06-16 2001-12-20 Transmit Technologietransfer Verwendung von Curcuminen zur Behandlung von soliden Tumoren,insbesondere von Hirntumoren
US6900356B2 (en) * 2001-04-18 2005-05-31 Laila Impex Polyhydroxy curcumins having antioxidant activity
US7355081B2 (en) 2002-04-17 2008-04-08 The University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
US6790979B2 (en) * 2002-04-17 2004-09-14 University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
AU2002314566A1 (en) * 2002-06-17 2003-12-31 Ho-Jeong Kwon Novel curcumin derivatives
DE102005008262A1 (de) * 2005-02-22 2006-08-24 Basf Ag Verfahren zur Herstellung von Curcumin
WO2007110168A1 (en) * 2006-03-29 2007-10-04 Dsm Ip Assets B.V. Curcumin synthesis
US20100048957A1 (en) * 2006-06-05 2010-02-25 Kim Darrick S H L Method to prepare pure curcumin
US7507864B2 (en) * 2006-08-01 2009-03-24 Salisbury University Method for the synthesis of curcumin analogues
JP5246779B2 (ja) 2006-11-30 2013-07-24 国立大学法人東京工業大学 新規クルクミン誘導体
US9000222B2 (en) 2007-01-08 2015-04-07 Androscience Corporation Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
CN101711231B (zh) 2007-01-08 2014-03-12 安德鲁科技有限公司 具有(取代苯基)-丙烯醛部分的化合物、它们的衍生物、生物活性及其用途
US8710272B2 (en) 2007-01-08 2014-04-29 Androscience Corporation Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
EP2136797A4 (en) * 2007-04-17 2013-08-21 Codman & Shurtleff INTRANASAL ADMINISTRATION OF CURCUMINE IN A HELIUM GAS BOLUS FOR THE TREATMENT OF MORBUS ALZHEIMER
EP2175726A4 (en) 2007-07-31 2011-01-05 Androscience Corp COMPOSITIONS WITH ANDROGEN RECEPTOR DERIVATIVES AND METHOD FOR THE PROPHYLACTIC OR THERAPEUTIC TREATMENT OF SKIN DISEASES OR HAIR LOSS
US7745670B2 (en) * 2008-06-27 2010-06-29 Codman & Shurtleff, Inc. Curcumin-Resveratrol hybrid molecule
US7985776B2 (en) * 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
US7723515B1 (en) 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
ES2761173T3 (es) 2009-05-15 2020-05-19 Univ New York State Res Found Análogos de curcumina como quelantes de zinc y sus usos
US9393198B2 (en) * 2010-03-22 2016-07-19 Signpath Pharma Inc. Intravenous curcumin and derivatives for treatment of neurodegenerative and stress disorders
US10349884B2 (en) 2011-06-03 2019-07-16 Sighpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
CA2836904C (en) 2011-06-03 2019-09-24 Signpath Pharma Inc. Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current
US12004868B2 (en) 2011-06-03 2024-06-11 Signpath Pharma Inc. Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel
US10238602B2 (en) 2011-06-03 2019-03-26 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies
ES2896105T3 (es) 2011-06-03 2022-02-23 Signpath Pharma Inc Mitigación liposomal del síndrome de QT largo inducido por un fármaco y corriente rectificadora retardada de potasio
US10449193B2 (en) 2011-06-03 2019-10-22 Signpath Pharma Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
US10117881B2 (en) 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
ES2837014T3 (es) 2012-05-08 2021-06-29 Asac Compania De Biotecnologia E Investig Sa Procedimiento para la síntesis de curcumina
AU2013274105A1 (en) 2012-06-14 2014-12-18 Signpath Pharma, Inc. Method and system for measuring the pharmacokinetics of liposomal curcumin and its metabolite tetrahydrocurcumin
CA2882978A1 (en) 2012-08-31 2014-03-06 University Of North Texas Health Science Center Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy
CA2933204C (en) 2013-12-18 2020-04-28 Signpath Pharma, Inc. Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel
JP6846052B2 (ja) 2016-03-22 2021-03-24 国立研究開発法人科学技術振興機構 クルクミンホウ素錯体及びこれを含有する医薬
KR102603673B1 (ko) 2016-04-27 2023-11-17 사인패스 파마 인코포레이티드 약물 유발된 방실 차단의 방지
CN110551026B (zh) * 2018-06-04 2022-02-15 永胜光学股份有限公司 改质姜黄素及其制备方法
US11434189B1 (en) * 2021-10-20 2022-09-06 I-Mei Foods Co., Ltd. Method for isolating curcuminoids from turmeric rhizome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE859145C (de) * 1944-04-22 1952-12-11 Hoechst Ag Verfahren zur Herstellung von symmetrischen 1, 3-Diketonen
NL255427A (no) * 1959-08-31
DE1280849B (de) * 1967-06-10 1968-10-24 Ludwig Heumann & Co Chem Pharm Verfahren zur Herstellung von Curcumin aus Vanillin und Acetylaceton
DE1282642B (de) * 1967-12-09 1968-11-14 Ludwig Heumann & Co Chemisch P Verfahren zur Herstellung von Curcumin aus Vanillin und Acetylaceton

Also Published As

Publication number Publication date
BR9611412A (pt) 1999-12-28
MX9803546A (es) 1998-11-29
EP0861223A1 (en) 1998-09-02
CA2236600A1 (en) 1997-05-09
EP0861223B1 (en) 2003-12-17
JP3346576B2 (ja) 2002-11-18
WO1997016403A1 (en) 1997-05-09
NO981974D0 (no) 1998-04-30
US5679864A (en) 1997-10-21
HUP9901894A2 (hu) 1999-09-28
ATE256652T1 (de) 2004-01-15
DE69631155T2 (de) 2004-09-02
ES2213183T3 (es) 2004-08-16
DE69631155D1 (de) 2004-01-29
PL326452A1 (en) 1998-09-28
DK0861223T3 (da) 2004-04-05
AU7551096A (en) 1997-05-22
JPH11502232A (ja) 1999-02-23
KR19990067279A (ko) 1999-08-16

Similar Documents

Publication Publication Date Title
NO981974L (no) FremgangsmÕte for syntesen av curcuminrelaterte forbindelser
Markó et al. Radical mediated oxidations in organic chemistry. 3. An efficient and versatile transformation of aldehydes into amides¥.
US4628084A (en) Process for 3-acylamino benzodiazepines
Shiragami et al. Synthesis of 2', 3'-dideoxyuridine via deoxygenation of 2', 3'-O-(methoxymethylene) uridine
US5344974A (en) Process for the preparation of N-acyl derivatives of 5-aminolevulinic acid, as well as the hydrochloride of the free acid
Spaltenstein et al. New synthesis of 4-and 5-imidazolethiols
Collin et al. Reductive couplings of acid chlorides mediated by SmI2
Zehavi Photochemical reactions of phenylglyoxalyl amides
McKenzie et al. The gomberg‐bachmann reaction of purines
US4480106A (en) Process for the preparation of asymmetrically substituted maleic anhydrides, and asymmetrically substituted maleic anhydrides
US5684161A (en) Process for preparing 1-substituted pyrrole-3-carboxylic acid derivatives
FI961680A0 (fi) Menetelmä epäsymmetrisesti substituoitujen triatsiinien valmistamiseksi
Hu et al. Photochemical reactions of sulfide-containing alkyl phenylglyoxylates
JPH04504405A (ja) シアノジエン類、ハロピリジン類、中間体及びそれらの製造方法
JP2579532B2 (ja) アミノアセトニトリル誘導体及びその製造方法
US4438276A (en) Process for synthesizing N-isopropyl-N'-o-carbomethoxyphenylsulphamide
US4279836A (en) Hydroxamic acid derivative and method of preparing metoclopramide using same
Strong et al. Monoesters of cyclohexane-1. beta., 3. beta., 5. beta.-triol
Ogura et al. A novel preparation of 3-methylthio-2-oxopropanal acetals using methylthiomethyl p-tolyl sulfone
Yamazaki et al. C‐5 functionalization of trisubstituted imidazoles with azodicarbonyl compounds
JP2005126340A (ja) 置換ピリドン類の製造法、その原料化合物及びその製造方法
Atsumi et al. A new synthetic route to 7 α-methoxycephalosporins
SU1167184A1 (ru) Способ получени 4- @ -селенопиранов
KR910000481B1 (ko) 피리딘 유도체의 제조방법
Goralski et al. The synthesis of 13C labelled N, N′‐dimethyl 2‐naphthaleneethanimidamide monohydrochloride, a potential psychotherapeutic agent