BR9510410A - Composto, composição farmacêutica ou veterinária, processo para produzir o composto e uso do composto - Google Patents
Composto, composição farmacêutica ou veterinária, processo para produzir o composto e uso do compostoInfo
- Publication number
- BR9510410A BR9510410A BR9510410-0A BR9510410A BR9510410A BR 9510410 A BR9510410 A BR 9510410A BR 9510410 A BR9510410 A BR 9510410A BR 9510410 A BR9510410 A BR 9510410A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- alkyl
- compound
- nhco
- nco2r
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Patente de Invenção "COMPOSTO, COMPOSIçãO FARMACêUTICA OU VETERINáRIA, PROCESSO PARA PRODUZIR O COMPOSTO E USO DO COMPOSTO". Um derivado de piperazinodiona de fórmula (I): na qual R^ 1^é (i) um grupo no qual p é 0 ou 2; cada um de R~ a~ a R~ e~, que podem ser iguais ou diferentes, é independentemente selecionado de hidrogênio, C~ 1~-C~ 6~-alquila não-substituída ou substituída com um ou mais átomos de halogênio, C~ 1~-C~ 6~-alquenila, C~ 1~-C~ 6~-alcoxila, C~ 1~-C~ 6~-alquil-tio, halogênio, hidroxila, nitro, fenila opcionalmente substituída, ciano, -CH2OH, -CH2COOH, -CO2R^ 11^, -NRCOR^ 11^, -NHSOR^ 13^, -SO2R^ 13^, -COn(R^ 11^R^ 12^), -SOR^ 13^, - SO2)n(R^ 11^R^ 12^), -O(CH2)n(R^ 11^R^ 12^), -O(CH2)nCO2R^ 11^, -OCOR^ 11^, -CH2OCOR^ 11^, -CH2)nHCOR^ 11^, -CH2)nHCOOR^ 13^, -CH2SR^ 11^, -CH2SCOR^ 11^, -CH2S (O)mR^ 13^, em que m é 1 ou 2, -CH2)nHCO(CH2)nCO2R^ 11^, -N(R^ 11^)COR^ 12^, -NHCOCF3, - NHCO(CH2)nCO2R^ 11^. -NHCO(CH2)nOCOR^ 11^e -NHCO(CH2)n(CO2R^ 11^; na qual n é 0 ou é um número inteiro de 1 a 6, cada um de R^ 11^ e R^ 12^ é independentemente selecionado de H ou C~ 1~-C~ 6~-alquila e R^ 13^ é C~ 1~-C~6~-alquila; ou qualquer um de R~ a~ e R~ b~, R~ b~ e R~ c~ e R~ d~ e ou R~ d~ e R~ e~ juntos formam um grupo metileno-dioxila, ou formam juntos com os átomos de carbono nos quais estão ligados um anel benzeno que está opcionalmente substituído; (ii) um grupo heterocíclico de 5 ou 6 membros contendo pelo menos um heteroátomo selecionado de ), N e S, cujo grupo pode estar fundido em um sal benzeno; (iii) um grupo C~ 1~-C~ 6~-alquila ou C~ 5~-C~ 7~-ciclo-alquila; ou (iv) um grupo C~ 5~-C~ 7~-ciclo-alquenila que está não-substituído ou substituído com uma C~ 2~-C~6~-alquenila; R^ 2^ é H, C~ 1~-C~ 6~-alquila opcionalmente substituída com um grupo -N(R^ 11^R^ 12^) como definido acima, C~ 3~-C~ 6~-ciclo-alquila, C~ 2~-C~ 6~-alquenila, -COOR^ 11^ no qual R^ 11^ é como o definido acima ou um grupo fenila como definido sob (i) acima, mais é diferente de H quando R^ 1^ for fenila não-substituída; e um de R^ 3^ e R^ 4^ é hidrogênio e o outro é um grupo de fórmula (A); na qual q é um número inteiro de 1 a 4, r é 0 ou 1 e R^ 5^ e R^ 6^, que podem ser iguais ou diferentes, são cada um H ou C~ 1~-C~ 6~-alcoxila, ou R^ 5^ e R^ 6^ juntos formam um grupo metileno-dioxila; e <sym> é uma ligação dupla ou, se R^ 1^ for como o definido sob (i) acima, é ima ligação dupla ou uma ligação simples; ou um seu sal farmaceuticamente aceitável.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426224.3A GB9426224D0 (en) | 1994-12-23 | 1994-12-23 | Pharmaceutical compounds |
| PCT/GB1995/003027 WO1996020190A1 (en) | 1994-12-23 | 1995-12-22 | Piperazine 2,5 dione derivatives as modulators of multi-drug resistance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9510410A true BR9510410A (pt) | 1999-09-08 |
Family
ID=10766589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9510410-0A BR9510410A (pt) | 1994-12-23 | 1995-12-22 | Composto, composição farmacêutica ou veterinária, processo para produzir o composto e uso do composto |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0799222A1 (pt) |
| JP (1) | JPH10511384A (pt) |
| CN (1) | CN1175253A (pt) |
| AU (1) | AU698828B2 (pt) |
| BG (1) | BG101602A (pt) |
| BR (1) | BR9510410A (pt) |
| CA (1) | CA2207500A1 (pt) |
| CZ (1) | CZ190097A3 (pt) |
| FI (1) | FI972660L (pt) |
| GB (1) | GB9426224D0 (pt) |
| HU (1) | HUT77943A (pt) |
| IL (1) | IL116525A0 (pt) |
| NO (1) | NO972937D0 (pt) |
| NZ (1) | NZ297847A (pt) |
| PL (1) | PL320916A1 (pt) |
| SK (1) | SK83697A3 (pt) |
| TW (1) | TW358094B (pt) |
| WO (1) | WO1996020190A1 (pt) |
| ZA (1) | ZA9510909B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0001531A3 (en) * | 1996-10-18 | 2000-09-28 | Xenova Ltd Slough | Anthranilic acid derivatives as multi drug resistance modulators |
| GB9717576D0 (en) * | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| US6605607B1 (en) | 1998-10-08 | 2003-08-12 | Smithkline Beecham P.L.C. | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) |
| MXPA02006826A (es) * | 2000-01-18 | 2004-04-05 | Nereus Phamraceuticals Inc | Un inhibidor de division celular y un metodo de produccion del mismo. |
| AU2001288829A1 (en) | 2000-09-06 | 2002-03-22 | Ap Pharma, Inc. | Degradable polyacetal polymers |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| ATE374767T1 (de) | 2002-08-02 | 2007-10-15 | Nereus Pharmaceuticals Inc | Dehydrophenylahistine und analoge davon sowie ein verfahren zur herstellung von dehydrophenylahistinen und analogen davon |
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| CN103396372B (zh) * | 2013-08-09 | 2015-05-20 | 中国科学院南海海洋研究所 | 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用 |
| JP6769982B2 (ja) | 2015-03-06 | 2020-10-14 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | Ｒａｓ変異と関連するがんの治療方法 |
| EP3265091A4 (en) | 2015-03-06 | 2018-08-01 | Beyondspring Pharmaceuticals Inc. | Method of treating a brain tumor |
| CN108026075B (zh) | 2015-07-13 | 2021-06-29 | 大连万春布林医药有限公司 | 普那布林组合物 |
| RU2753543C1 (ru) | 2016-02-08 | 2021-08-17 | Бейондспринг Фармасьютикалс, Инк. | Композиции, содержащие тукаресол или его аналоги |
| EP3463337A4 (en) | 2016-06-06 | 2020-02-12 | Beyondspring Pharmaceuticals, Inc. | COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA |
| WO2018129381A1 (en) | 2017-01-06 | 2018-07-12 | Beyondspring Pharmaceuticals, Inc. | Tubulin binding compounds and therapeutic use thereof |
| SG11201907023UA (en) | 2017-02-01 | 2019-08-27 | Beyondspring Pharmaceuticals Inc | Method of reducing neutropenia |
| BR112020014960A2 (pt) | 2018-01-24 | 2020-12-22 | Beyondspring Pharmaceuticals, Inc. | Composição e método para redução de trombocitopenia |
| JP2024513505A (ja) | 2021-04-09 | 2024-03-25 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | 腫瘍を治療するための組成物及び方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0649410T3 (da) * | 1992-07-10 | 1997-09-15 | Glaxo Lab Sa | Anilidderivater. |
| GB9217331D0 (en) * | 1992-08-14 | 1992-09-30 | Xenova Ltd | Pharmaceutical compounds |
-
1994
- 1994-12-23 GB GBGB9426224.3A patent/GB9426224D0/en active Pending
-
1995
- 1995-12-21 ZA ZA9510909A patent/ZA9510909B/xx unknown
- 1995-12-22 SK SK836-97A patent/SK83697A3/sk unknown
- 1995-12-22 AU AU43100/96A patent/AU698828B2/en not_active Ceased
- 1995-12-22 WO PCT/GB1995/003027 patent/WO1996020190A1/en not_active Ceased
- 1995-12-22 IL IL11652595A patent/IL116525A0/xx unknown
- 1995-12-22 NZ NZ297847A patent/NZ297847A/en unknown
- 1995-12-22 EP EP95941797A patent/EP0799222A1/en not_active Withdrawn
- 1995-12-22 JP JP8520301A patent/JPH10511384A/ja active Pending
- 1995-12-22 CA CA002207500A patent/CA2207500A1/en not_active Abandoned
- 1995-12-22 PL PL95320916A patent/PL320916A1/xx unknown
- 1995-12-22 BR BR9510410-0A patent/BR9510410A/pt not_active Application Discontinuation
- 1995-12-22 CN CN95197672A patent/CN1175253A/zh active Pending
- 1995-12-22 CZ CZ971900A patent/CZ190097A3/cs unknown
- 1995-12-22 FI FI972660A patent/FI972660L/fi unknown
- 1995-12-22 HU HU9800398A patent/HUT77943A/hu unknown
- 1995-12-23 TW TW084113836A patent/TW358094B/zh active
-
1997
- 1997-06-11 BG BG101602A patent/BG101602A/xx unknown
- 1997-06-23 NO NO972937A patent/NO972937D0/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9426224D0 (en) | 1995-02-22 |
| AU4310096A (en) | 1996-07-19 |
| NZ297847A (en) | 1999-04-29 |
| FI972660A7 (fi) | 1997-08-22 |
| NO972937L (no) | 1997-06-23 |
| PL320916A1 (en) | 1997-11-10 |
| FI972660A0 (fi) | 1997-06-19 |
| CA2207500A1 (en) | 1996-07-04 |
| SK83697A3 (en) | 1998-05-06 |
| EP0799222A1 (en) | 1997-10-08 |
| NO972937D0 (no) | 1997-06-23 |
| IL116525A0 (en) | 1996-03-31 |
| FI972660L (fi) | 1997-08-22 |
| JPH10511384A (ja) | 1998-11-04 |
| BG101602A (en) | 1998-02-27 |
| CZ190097A3 (cs) | 1998-01-14 |
| WO1996020190A1 (en) | 1996-07-04 |
| ZA9510909B (en) | 1996-08-30 |
| TW358094B (en) | 1999-05-11 |
| AU698828B2 (en) | 1998-11-05 |
| CN1175253A (zh) | 1998-03-04 |
| HUT77943A (hu) | 1998-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |