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BR0208363A - Produtos de formulação de solução aerossol medicinal com estabilidade quìmica melhorada - Google Patents

Produtos de formulação de solução aerossol medicinal com estabilidade quìmica melhorada

Info

Publication number
BR0208363A
BR0208363A BR0208363-9A BR0208363A BR0208363A BR 0208363 A BR0208363 A BR 0208363A BR 0208363 A BR0208363 A BR 0208363A BR 0208363 A BR0208363 A BR 0208363A
Authority
BR
Brazil
Prior art keywords
solution formulation
aerosol solution
chemical stability
improved chemical
formulation products
Prior art date
Application number
BR0208363-9A
Other languages
English (en)
Inventor
David Lewis
Gaetano Brambilla
David Ganderton
Brian Meakin
Alessandra Ferraris
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BR0208363A publication Critical patent/BR0208363A/pt

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/44—Valves specially adapted for the discharge of contents; Regulating devices
    • B65D83/52—Metering valves; Metering devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers for dispensing liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant
    • B65D83/38—Details of the container body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

"PRODUTOS DE FORMULAçãO DE SOLUçãO AEROSSOL MEDICINAL COM ESTABILIDADE QUìMICA MELHORADA". A presente invenção refere-se a um produto de formulação de solução aerossol medicinal com estabilidade química melhorada, compreendendo um inalador de dose medida pressurizada, compreendendo um recipiente de aerossol equipado com uma válvula de medição e contendo uma formulação de solução aerossol medicinal contendo um princípio ativo sujeito à degradação por peróxidos, um propelente de hidrofluorocarboneto, um co-solvente e, opcionalmente, um componente de baixa volatilidade, onde parte das superfícies ou todas as superfícies internas do referido inalador consistem de aço inoxidável, alumínio anodizado ou são revestidas com um revestimento orgânico inerte, e onde o recipiente possui uma extremidade com bordas arredondadas que evita rupturas nas borrachas usadas como gaxetas de válvula.
BR0208363-9A 2001-03-12 2002-03-12 Produtos de formulação de solução aerossol medicinal com estabilidade quìmica melhorada BR0208363A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01105410A EP1241113A1 (en) 2001-03-12 2001-03-12 Inhaler with means for improving chemical stability of medicinal aerosol solution contained therein
PCT/EP2002/002710 WO2002072448A1 (en) 2001-03-12 2002-03-12 Inhaler with means for improving chemical stability of medicinal aerosol solution contained therein

Publications (1)

Publication Number Publication Date
BR0208363A true BR0208363A (pt) 2004-03-09

Family

ID=8176686

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208363-9A BR0208363A (pt) 2001-03-12 2002-03-12 Produtos de formulação de solução aerossol medicinal com estabilidade quìmica melhorada

Country Status (9)

Country Link
EP (2) EP1241113A1 (pt)
JP (1) JP2004526495A (pt)
AT (1) ATE388099T1 (pt)
AU (1) AU2002308254B2 (pt)
BR (1) BR0208363A (pt)
CA (1) CA2437746A1 (pt)
DE (1) DE60225421T9 (pt)
NZ (1) NZ528443A (pt)
WO (1) WO2002072448A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003222753B2 (en) 2002-03-01 2008-04-17 Chiesi Farmaceutici S.P.A. Formoterol superfine formulation
HRP20050822B1 (hr) 2003-03-20 2013-09-30 Boehringer Ingelheim Pharmaceuticals Inc. Formulacija za inhalator s odmjerenom dozom koji koristi hidro-fluoro-alkane kao propelente
EP1915985A1 (en) 2003-03-20 2008-04-30 Boehringer Ingelheim Pharmaceuticals Inc. Formulation for a Metered Dose Inhaler Using Hydro-Fluoro-Alkanes as Propellants
ES2449718T3 (es) * 2003-08-11 2014-03-20 Glaxo Group Limited Inhalador de dosis farmacéutica medida y procedimiento relacionados con el mismo
JP2007509147A (ja) * 2003-10-20 2007-04-12 シェーリング　コーポレイション 薬学的エアロゾル組成物
EP1925293A3 (en) * 2003-10-20 2010-01-13 Schering Corporation Pharmaceutical aerosol compositions
MXPA06015204A (es) 2004-07-02 2007-03-15 Boehringer Ingelheim Int Formulaciones en suspension de aerosol con tg 227 ea o tg 134 a como agentes propulsores.
US20080216825A1 (en) * 2005-08-08 2008-09-11 Dilraj Singh Insulated Cansister for Metered Dose Inhalers
WO2007112312A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Medicinal formulation container with a treated metal surface
DE102006017320A1 (de) 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
AU2007346134A1 (en) * 2007-02-09 2008-08-14 Merck Sharp & Dohme Corp. Stable pharmaceutical drug aerosols
US8227027B2 (en) 2007-12-07 2012-07-24 Presspart Gmbh & Co. Kg Method for applying a polymer coating to an internal surface of a container
DK2711309T3 (en) * 2012-09-20 2016-09-26 Presspart Gmbh & Co Kg A container for a metered dose and method of producing such a container
DK3089735T3 (en) * 2013-12-30 2018-09-17 Chiesi Farm Spa STABLE PRESSURE AEROSOL SOLUTION COMPOSITION OF GLYCOPYRRONIUM BROMIDE AND FORMOTEROL COMBINATION
PE20221867A1 (es) * 2020-01-28 2022-12-02 Chiesi Farm Spa Inhaladores de dosis medida presurizada que comprenden una formulacion farmaceutica amortiguada

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4271875A (en) * 1978-09-21 1981-06-09 Philip Meshberg Dispenser adapted for fast pressure filling
US4800903A (en) * 1985-05-24 1989-01-31 Ray Jon P Nicotine dispenser with polymeric reservoir of nicotine
EP0673240B1 (en) 1992-12-09 1999-03-24 Boehringer Ingelheim Pharmaceuticals Inc. Stabilized medicinal aerosol solution formulations
US5899201A (en) * 1993-05-26 1999-05-04 Minnesota Mining And Manufacturing Company Aerosol actuator
CA2178473C (en) 1993-12-20 2004-08-24 Tsi-Zong Tzou Flunisolide aerosol formulations
DE69637257T2 (de) 1995-04-14 2008-06-12 Smithkline Beecham Corp. Verfahren zur Herstellung eines Dosierinhalators
JP2002512871A (ja) * 1998-04-30 2002-05-08 スリーエム イノベイティブ プロパティズ カンパニー 製薬エアロゾル用定量弁
DZ2947A1 (fr) 1998-11-25 2004-03-15 Chiesi Farma Spa Inhalateur à compteur de dose sous pression.
US6290930B1 (en) 1998-12-18 2001-09-18 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes and budesonide
FR2793478B1 (fr) * 1999-05-11 2001-07-27 Oreal Dispositif de montage d'une valve sur un reservoir, et distributeur contenant un produit sous pression, equipe d'un tel dispositif
US6315985B1 (en) 1999-06-18 2001-11-13 3M Innovative Properties Company C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability
CN1213732C (zh) 2000-05-22 2005-08-10 奇斯药制品公司 用于加压计量吸入器的稳定药用溶液制剂

Also Published As

Publication number Publication date
DE60225421T9 (de) 2010-04-15
EP1241113A1 (en) 2002-09-18
DE60225421D1 (de) 2008-04-17
CA2437746A1 (en) 2002-09-19
DE60225421T2 (de) 2009-07-16
WO2002072448A1 (en) 2002-09-19
AU2002308254C1 (en) 2002-09-24
JP2004526495A (ja) 2004-09-02
EP1368253B1 (en) 2008-03-05
EP1368253A1 (en) 2003-12-10
ATE388099T1 (de) 2008-03-15
NZ528443A (en) 2004-08-27
AU2002308254B2 (en) 2007-05-17

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Legal Events

Date Code Title Description
B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: PARA QUE SEJA ACEITA A PETICAO DE EXAME NO 8715/SP DE 16/05/2006 APRESENTE PETICAO DE DESARQUIVAMENTO DO PEDIDO, BEM COMO A RESPECTIVA RETRIBUICAO RELATIVA AO CUMPRIMENTO DE EXIGENCIA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010.