BG25090A3 - Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли - Google Patents

Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли

Info

Publication number: BG25090A3
Authority: BG; Bulgaria
Prior art keywords: benzomorphanes; tetrahydrofurfuryl; beta; salts; substituted
Prior art date: 1974-08-05

Application number

BG031843A

Other languages

Bulgarian (bg)

English (en)

Inventor

Herbert Merz

Adolf Langbein

Gerhard Walther

Klaus Stockhaus

Original Assignee

C.H.Boehringer Sohn

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-08-05

Filing date

1975-08-02

Publication date

1978-07-12

1975-08-02 Application filed by C.H.Boehringer Sohn filed Critical C.H.Boehringer Sohn

1978-07-12 Publication of BG25090A3 publication Critical patent/BG25090A3/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG031843A 1974-08-05 1975-08-02 Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли BG25090A3 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE2437610A DE2437610A1 (de)	1974-08-05	1974-08-05	Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number	Publication Date
BG25090A3 true BG25090A3 (bg)	1978-07-12

Family

ID=5922448

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
BG031843A BG25090A3 (bg)	1974-08-05	1975-08-02	Метод за получаване на 5,9-бета-заместени -2-тетрахидрофурфурил- 6,7-бензоморфани и техните соли
BG030726A BG25088A3 (bg)	1974-08-05	1975-08-02	Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли
BG031842A BG25089A3 (bg)	1974-08-05	1975-08-02	Метод за получаване на 5,9-бета-заместени 2-тетра-хидрофурфурил-6,7- бензоморфани и техните соли

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
BG030726A BG25088A3 (bg)	1974-08-05	1975-08-02	Метод за получаване на 5,9-бета заместени 2-тетрахидро-фурфурил-6,7- бензоморфани и техните соли
BG031842A BG25089A3 (bg)	1974-08-05	1975-08-02	Метод за получаване на 5,9-бета-заместени 2-тетра-хидрофурфурил-6,7- бензоморфани и техните соли

Country Status (27)

Country	Link
US (1)	US3982005A (xx)
JP (1)	JPS60358B2 (xx)
AT (1)	AT348140B (xx)
BE (1)	BE832099R (xx)
BG (3)	BG25090A3 (xx)
CA (1)	CA1049008A (xx)
CH (7)	CH613963A5 (xx)
CS (1)	CS189717B2 (xx)
DD (1)	DD122685A5 (xx)
DE (1)	DE2437610A1 (xx)
DK (1)	DK138992C (xx)
ES (6)	ES452764A1 (xx)
FI (1)	FI63229C (xx)
FR (1)	FR2320096A2 (xx)
GB (1)	GB1513950A (xx)
HU (1)	HU177952B (xx)
IE (1)	IE42216B1 (xx)
IL (1)	IL47860A (xx)
LU (1)	LU73138A1 (xx)
NL (1)	NL7509249A (xx)
NO (1)	NO143460C (xx)
PH (1)	PH13687A (xx)
PL (3)	PL99819B1 (xx)
RO (3)	RO67390A (xx)
SE (1)	SE425392B (xx)
SU (3)	SU591147A3 (xx)
ZA (1)	ZA754997B (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4087532A (en) *	1974-03-09	1978-05-02	Boehringer Ingelheim Gmbh	Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
GB1575009A (en) *	1976-06-21	1980-09-17	Acf Chemiefarma Nv	6,7-benzomorphan derivatives
DE2716687A1 (de) *	1977-04-15	1978-10-19	Boehringer Sohn Ingelheim	2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel
NL7804509A (nl) *	1978-04-26	1979-10-30	Acf Chemiefarma Nv	Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.
DE2828039A1 (de) *	1978-06-26	1980-01-10	Boehringer Sohn Ingelheim	2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
JPS5636521A (en) *	1979-08-31	1981-04-09	Shin Etsu Chem Co Ltd	Production of alkenyloxy group-containing organopolysiloxane
US8329897B2 (en)	2007-07-26	2012-12-11	Vitae Pharmaceuticals, Inc.	Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
CA2704628C (en)	2007-11-16	2016-11-29	Boehringer Ingelheim International Gmbh	Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
CA2708303A1 (en)	2007-12-11	2009-06-18	Vitae Pharmaceuticals, Inc.	Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en)	2008-01-07	2009-08-16	Vitae Pharmaceuticals Inc	Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
JP5490020B2 (ja)	2008-01-24	2014-05-14	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状カルバゼート及びセミカルバジドインヒビター
US8598160B2 (en)	2008-02-15	2013-12-03	Vitae Pharmaceuticals, Inc.	Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US8569292B2 (en)	2008-05-01	2013-10-29	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
PL2300461T3 (pl)	2008-05-01	2013-09-30	Vitae Pharmaceuticals Inc	Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1
CA2723034A1 (en)	2008-05-01	2009-11-05	Vitae Pharmaceuticals, Inc.	Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001151A1 (es)	2008-05-13	2010-08-13	Boehringer Ingelheim Int	Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos.
JP5379160B2 (ja)	2008-07-25	2013-12-25	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
TW201016691A (en)	2008-07-25	2010-05-01	Boehringer Ingelheim Int	Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
MA33216B1 (fr)	2009-04-30	2012-04-02	Boehringer Ingelheim Int	Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
JP5656986B2 (ja)	2009-06-11	2015-01-21	ヴァイティーファーマシューティカルズ，インコーポレイテッド	１，３−オキサジナン−２−オン構造に基づく１１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状阻害剤
TWI531571B (zh) *	2009-11-06	2016-05-01	維它藥物公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜芳基羰基衍生物
EP2582698B1 (en)	2010-06-16	2016-09-14	Vitae Pharmaceuticals, Inc.	Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh)	2010-11-05	2016-06-11	百靈佳殷格翰國際股份有限公司	六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
US8735585B2 (en)	2011-08-17	2014-05-27	Boehringer Ingelheim International Gmbh	Indenopyridine derivatives
CN116507689A (zh)	2020-11-26	2023-07-28	信越化学工业株式会社	室温固化性有机聚硅氧烷组合物及物品以及水解性有机硅烷化合物及其制造方法
EP4397695A4 (en)	2021-09-03	2025-09-10	Shinetsu Chemical Co	ORGANOPOLYSILOXANE COMPOUND, ROOM TEMPERATURE CURABLE ORGANOPOLYSILOXANE COMPOSITION AND ARTICLE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE582575A (xx) *	1958-09-22
US3700734A (en) *	1969-01-23	1972-10-24	Merck & Co Inc	2{40 -hydroxy-2,3,5-trimethyl-6,7-benzomorphan
DE2105743C3 (de) *	1971-02-08	1979-11-29	Boehringer Sohn Ingelheim	2-(Furylmethyl)- a -5,9-dialkyl -6,7benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
CS166803B2 (xx) *	1971-02-08	1976-03-29	Boehringer Sohn Ingelheim
DE2200596A1 (de) *	1972-01-07	1973-07-12	Boehringer Sohn Ingelheim	N-(furyl-methyl)-2'-hydroxy-5-phenyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
DE2217420C3 (de) *	1972-04-12	1981-03-12	C.H. Boehringer Sohn, 6507 Ingelheim	N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) *	1972-06-19	1974-01-31	Boehringer Sohn Ingelheim	2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung

1974
- 1974-08-05 DE DE2437610A patent/DE2437610A1/de not_active Ceased
1975
- 1975-07-08 AT AT523775A patent/AT348140B/de not_active IP Right Cessation
- 1975-07-25 SU SU752162235A patent/SU591147A3/ru active
- 1975-07-30 US US05/600,374 patent/US3982005A/en not_active Expired - Lifetime
- 1975-07-30 JP JP50092995A patent/JPS60358B2/ja not_active Expired
- 1975-07-30 RO RO7583017A patent/RO67390A/ro unknown
- 1975-07-31 RO RO7593231A patent/RO72736A/ro unknown
- 1975-07-31 CH CH1002475A patent/CH613963A5/xx not_active IP Right Cessation
- 1975-07-31 RO RO7593232A patent/RO72735A/ro unknown
- 1975-08-01 CA CA75232728A patent/CA1049008A/en not_active Expired
- 1975-08-02 BG BG031843A patent/BG25090A3/xx unknown
- 1975-08-02 BG BG030726A patent/BG25088A3/xx unknown
- 1975-08-02 BG BG031842A patent/BG25089A3/xx unknown
- 1975-08-04 NL NL7509249A patent/NL7509249A/xx not_active Application Discontinuation
- 1975-08-04 CS CS755425A patent/CS189717B2/cs unknown
- 1975-08-04 SE SE7508789A patent/SE425392B/xx not_active IP Right Cessation
- 1975-08-04 IL IL47860A patent/IL47860A/xx unknown
- 1975-08-04 DD DD187666A patent/DD122685A5/xx unknown
- 1975-08-04 BE BE158924A patent/BE832099R/xx not_active IP Right Cessation
- 1975-08-04 LU LU73138A patent/LU73138A1/xx unknown
- 1975-08-04 PH PH17443A patent/PH13687A/en unknown
- 1975-08-04 ZA ZA754997A patent/ZA754997B/xx unknown
- 1975-08-04 PL PL1975190658A patent/PL99819B1/pl unknown
- 1975-08-04 DK DK352875A patent/DK138992C/da active
- 1975-08-04 NO NO752731A patent/NO143460C/no unknown
- 1975-08-04 PL PL1975190659A patent/PL99816B1/pl unknown
- 1975-08-04 HU HU75BO1566A patent/HU177952B/hu unknown
- 1975-08-04 GB GB32576/75A patent/GB1513950A/en not_active Expired
- 1975-08-04 PL PL1975182528A patent/PL99838B1/pl unknown
- 1975-08-04 FI FI752211A patent/FI63229C/fi not_active IP Right Cessation
- 1975-08-05 IE IE1738/75A patent/IE42216B1/en unknown
- 1975-08-05 FR FR7524380A patent/FR2320096A2/fr active Granted
1976
- 1976-04-16 SU SU762346107A patent/SU587858A3/ru active
- 1976-04-16 SU SU762346108A patent/SU587859A3/ru active
- 1976-10-27 ES ES452764A patent/ES452764A1/es not_active Expired
- 1976-10-27 ES ES452765A patent/ES452765A1/es not_active Expired
- 1976-10-27 ES ES452763A patent/ES452763A1/es not_active Expired
- 1976-10-27 ES ES452766A patent/ES452766A1/es not_active Expired
- 1976-10-27 ES ES452768A patent/ES452768A1/es not_active Expired
- 1976-10-27 ES ES452767A patent/ES452767A1/es not_active Expired
1979
- 1979-04-26 CH CH393379A patent/CH616420A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393679A patent/CH615680A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393479A patent/CH615679A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393579A patent/CH616421A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393279A patent/CH615678A5/de not_active IP Right Cessation
- 1979-04-26 CH CH393179A patent/CH615677A5/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE42216L (en)	1976-02-05
CH615678A5 (xx)	1980-02-15
ZA754997B (en)	1977-04-27
CA1049008A (en)	1979-02-20
AU8364675A (en)	1977-02-10
PL99819B1 (pl)	1978-08-31
LU73138A1 (xx)	1977-04-13
FR2320096B2 (xx)	1978-09-01
CH615679A5 (xx)	1980-02-15
DK138992B (da)	1978-11-27
PL99816B1 (pl)	1978-08-31
CH613963A5 (xx)	1979-10-31
DK138992C (da)	1979-04-30
DK352875A (da)	1976-02-06
IL47860A0 (en)	1975-11-25
ES452766A1 (es)	1977-10-01
ES452767A1 (es)	1977-10-01
SU587859A3 (ru)	1978-01-05
US3982005A (en)	1976-09-21
CH615677A5 (xx)	1980-02-15
SE425392B (sv)	1982-09-27
JPS60358B2 (ja)	1985-01-07
SE7508789L (sv)	1976-02-10
CH615680A5 (xx)	1980-02-15
ATA523775A (de)	1978-06-15
AT348140B (de)	1979-01-25
PH13687A (en)	1980-09-01
RO67390A (ro)	1981-06-30
NL7509249A (nl)	1976-02-09
ES452764A1 (es)	1977-10-16
IE42216B1 (en)	1980-07-02
IL47860A (en)	1979-01-31
ES452763A1 (es)	1977-10-01
BE832099R (fr)	1976-02-04
FI63229B (fi)	1983-01-31
CH616421A5 (xx)	1980-03-31
NO143460C (no)	1981-02-18
FR2320096A2 (fr)	1977-03-04
JPS5139673A (en)	1976-04-02
DE2437610A1 (de)	1976-02-26
CH616420A5 (xx)	1980-03-31
ES452768A1 (es)	1977-10-01
PL99838B1 (pl)	1978-08-31
SU591147A3 (ru)	1978-01-30
RO72736A (ro)	1982-09-09
CS189717B2 (en)	1979-04-30
BG25089A3 (bg)	1978-07-12
SU587858A3 (ru)	1978-01-05
RO72735A (ro)	1982-09-09
FI752211A7 (xx)	1976-02-06
DD122685A5 (xx)	1976-10-20
HU177952B (en)	1982-02-28
GB1513950A (en)	1978-06-14
BG25088A3 (bg)	1978-07-12
FI63229C (fi)	1983-05-10
ES452765A1 (es)	1977-10-16
NO143460B (no)	1980-11-10
NO752731L (xx)	1976-02-06

Publication	Publication Date	Title
BG24814A4 (bg)	1978-05-12	Метод за получаване на 2-тетрахидрофурфурил-6,7 бензоморфани и техните соли
BG25089A3 (bg)	1978-07-12	Метод за получаване на 5,9-бета-заместени 2-тетра-хидрофурфурил-6,7- бензоморфани и техните соли
BG23212A3 (bg)	1977-07-12	Метод за получаване на арилоксифенилпропиламини
BG26512A3 (bg)	1979-04-12	Метод за получаване на амиди на 2,4,6-трийод-изофталовата киселина
BG25072A3 (bg)	1978-07-12	Метод за получаване на n-(1-бензилпиролидинил-2-алкил) субституирани бензамиди
BG25082A3 (bg)	1978-07-12	Метод за получаване на 1-ароил-2-ариламино-2-имидазолови производни
BG25220A3 (bg)	1978-08-10	Метод за получаване на 2,6-дисубституирани 2-фенилимино-имидазолидини и техните соли
FR2291764A1 (fr)	1976-06-18	Diacylnucleosides et procede de preparation
BG24539A3 (bg)	1978-03-10	Метод за получаване на 1-етил- за- субституирани - фенил - декахидроизохинолини
BG27546A4 (bg)	1979-11-12	Метод за получаване на n-тетрахидрофурил-порокси-морфини и техни соли
AR214315A1 (es)	1979-05-31	Metodo de preparacion de fenetil-alquil-aminas terciarias
BG25091A3 (bg)	1978-07-12	Метод за получаване на 7-ацилоамида-3-флуорцефалоспоринови съединения
BG27234A3 (bg)	1979-09-14	Метод за получаване на 2-карбалкоксиамино-5(6)- фенилсулфонилокси-бензимидазоли
BG26527A3 (bg)	1979-04-12	Метод за получаване на 2-ариламино-2-имидазолинови производни
BG24816A3 (bg)	1978-05-12	Метод за получаване на 4- оксо-4н пирано-/3,2-с/-хинолин-2 карбонови киселини и техните соли
BG27558A3 (bg)	1979-11-12	Метод за получаване на 7-в-/д-2-амино -2- метилсулфониламинофенил/ ацетиламино -3-r-3- цефем -4-карбонови киселини и техните соли
SE7504587L (sv)	1975-10-23	Prostansyraderivat och sett for deras framstellning.
BG23899A3 (bg)	1977-11-10	Метод за получаване на 1-2-(-нафтилокси)-етил-3-метил-пиразолон-(5).
BG25519A3 (bg)	1978-10-10	Метод за получаване на производни на пеницилиновата и цефалоспориновата киселина
BG24666A3 (bg)	1978-04-12	Метод за получаване на n-(2-пиролидинил-алкил)субституирани бензамиди и техните производни
SE417092B (sv)	1981-02-23	Forfarande for framstellning av 1,2,3,4-tetrahydroisokinoliner
IT1029677B (it)	1979-03-20	Metodo per la preparazione di ditiodianiline
BG26366A3 (bg)	1979-03-15	Метод за получаване на арилоксиаминобутаноли и техни производни
SE423992B (sv)	1982-06-21	Forfarande for framstellning av 9, 11, 15-trihydroxi-13, 14-dehydroprostaglandiner
BG26538A3 (bg)	1979-04-12	Метод за получаване на дикарбоксицефалоспорини и тяхните производни