[go: up one dir, main page]

BE850401A - Derives de phtalane et procede de preparation - Google Patents

Derives de phtalane et procede de preparation

Info

Publication number
BE850401A
BE850401A BE174098A BE174098A BE850401A BE 850401 A BE850401 A BE 850401A BE 174098 A BE174098 A BE 174098A BE 174098 A BE174098 A BE 174098A BE 850401 A BE850401 A BE 850401A
Authority
BE
Belgium
Prior art keywords
phthalane
derivatives
preparation process
preparation
phthalane derivatives
Prior art date
Application number
BE174098A
Other languages
English (en)
Inventor
K P Bogeso
A S Tofit
Original Assignee
Kefalas As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9722860&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE850401(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kefalas As filed Critical Kefalas As
Publication of BE850401A publication Critical patent/BE850401A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BE174098A 1976-01-14 1977-01-14 Derives de phtalane et procede de preparation BE850401A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1486/76A GB1526331A (en) 1976-01-14 1976-01-14 Phthalanes

Publications (1)

Publication Number Publication Date
BE850401A true BE850401A (fr) 1977-07-14

Family

ID=9722860

Family Applications (1)

Application Number Title Priority Date Filing Date
BE174098A BE850401A (fr) 1976-01-14 1977-01-14 Derives de phtalane et procede de preparation

Country Status (19)

Country Link
US (1) US4136193A (fr)
JP (1) JPS52105162A (fr)
AT (1) AT359488B (fr)
AU (1) AU509445B2 (fr)
BE (1) BE850401A (fr)
CA (1) CA1094087A (fr)
CH (3) CH626886A5 (fr)
DE (1) DE2657013C2 (fr)
DK (1) DK143275C (fr)
ES (1) ES454980A1 (fr)
FI (1) FI63754C (fr)
FR (1) FR2338271A1 (fr)
GB (1) GB1526331A (fr)
IE (1) IE44055B1 (fr)
NL (2) NL192451C (fr)
NO (2) NO147243C (fr)
NZ (1) NZ183001A (fr)
SE (1) SE429551B (fr)
ZA (1) ZA7757B (fr)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4602035A (en) * 1983-12-07 1986-07-22 Hoechst-Roussel Pharmaceuticals Inc. Antidepressant (3-aryl-2,3-dihydrobenzofuran-3-yl)alkylamines
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
EP0759299B1 (fr) * 1995-08-16 2000-04-26 Eli Lilly And Company Potentialisation de la sérotonine
ATE205824T1 (de) * 1997-07-08 2001-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (fr) * 1997-11-11 1998-05-14 H. Lundbeck A/S Procede de preparation de citaloprame
DE69904853T2 (de) 1998-10-20 2003-09-04 Lundbeck As Valby H Verfahren zur herstellung von citalopram
KR20010081071A (ko) 1998-12-08 2001-08-25 피터슨 존 메이달 벤조푸란 유도체, 그것들의 제조 및 사용
AR021509A1 (es) * 1998-12-08 2002-07-24 Lundbeck & Co As H Derivados de benzofurano, su preparacion y uso
CZ300408B6 (cs) 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PT1173431E (pt) * 1999-04-14 2003-09-30 Lundbeck & Co As H Metodo de preparacao do citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
IL143875A0 (en) 1999-10-25 2002-04-21 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
ES2219095T3 (es) 1999-12-28 2004-11-16 H. Lundbeck A/S Metodo para la preparacion de citalopram.
CA2395733C (fr) * 1999-12-30 2007-03-20 H. Lundbeck A/S Procede de preparation de citaloprame
HK1054392B (zh) * 2000-01-14 2005-11-18 H‧隆德贝克有限公司 製備5-氰基2-苯並[c]呋喃酮的方法
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) * 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
BR0109176A (pt) * 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
MXPA02008653A (es) 2000-03-14 2003-02-24 Lundbeck & Co As H Metodo para la preparacion de citalopram.
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AU2001257022B2 (en) * 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
US6977306B2 (en) 2000-05-02 2005-12-20 Sumitomo Chemical Company, Limited Citalopram hydrobromide crystal and method for crystallization thereof
AR032455A1 (es) * 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
KR100821912B1 (ko) * 2000-05-12 2008-04-16 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
IL148525A0 (en) * 2000-07-06 2002-09-12 Lundbeck & Co As H Method for the preparation of citalopram
ES2238466T3 (es) * 2000-07-21 2005-09-01 H. Lundbeck A/S Compuestos y su uso como inhibidores del transporte de glicina.
IES20010693A2 (en) 2000-08-10 2002-07-10 Lundbeck & Co As H Pharmaceutical composition containing citalopram
CA2354880C (fr) * 2000-08-18 2003-06-03 H. Lundbeck A/S Procede de preparation du citaloprame
US20030109577A1 (en) * 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram
US20030232881A1 (en) * 2000-10-27 2003-12-18 H. Lundbeck A/S Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them
IT1319686B1 (it) * 2000-12-12 2003-10-23 C D Farmasint S R L Procedimento di preparazione di citalopram.
IL147226A (en) * 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
DE10112828C1 (de) * 2000-12-28 2002-11-21 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
DE10164725B4 (de) * 2000-12-28 2004-08-26 H. Lundbeck A/S Verfahren zur Herstellung von gereinigtem Citalopram
TR200200018T1 (tr) * 2000-12-28 2002-06-21 H. Lundbeck A/S Saf sitalopram hazırlanması için yöntem.
AU2001100195B4 (en) * 2001-01-05 2001-12-20 H Lundbeck As Pharmaceutical composition containing citalopram.
WO2002060886A1 (fr) * 2001-01-30 2002-08-08 Orion Corporation, Fermion Procede de preparation de 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
JP2004529883A (ja) * 2001-02-22 2004-09-30 ナトコ ファーマ リミテッド シタロプラムの調製方法
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
RU2003130073A (ru) * 2001-03-09 2005-04-10 Ранбакси Лабораторис Лимитед (In) Способ получения циталопрама
MXPA03008777A (es) * 2001-05-01 2004-02-12 Lundbeck & Co As H El uso de escitalopram enantiomericamente puro.
BG65271B1 (bg) * 2001-06-18 2007-11-30 H. Lundbeck A/S Метод за получаване на циталопрам
AR034759A1 (es) * 2001-07-13 2004-03-17 Lundbeck & Co As H Metodo para la preparacion de escitalopram
IN192057B (fr) * 2001-07-19 2004-02-14 Ranbaxy Lab Ltd
ES2280892T3 (es) * 2001-07-31 2007-09-16 H. Lundbeck A/S Composicion cristalina que contiene escitalopram.
EP1288211A1 (fr) * 2001-08-28 2003-03-05 Sekhsaria Chemicals Ltd. Procédé amélioré pour la préparation d'hydrobromure de Citalopram à partir de 5-bromophthalide
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
ES2666188T3 (es) * 2001-10-12 2018-05-03 Azevan Pharmaceuticals, Inc. Antagonistas del v1a de vasopresina beta-lactámicos
IN192863B (fr) * 2001-11-13 2004-05-22 Ranbaxy Lab Ltd
IS7239A (is) * 2001-12-14 2004-04-29 H. Lundbeck A/S Aðferð til framleiðslu á essítalóprami
AU2003222435A1 (en) * 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2385848A (en) * 2002-02-27 2003-09-03 Cipla Ltd Citalopram salts
GB2387844B (en) * 2002-02-27 2005-05-11 Matrix Lab Ltd Separation of impurities from a crude mixture of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (fr) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Procede ameliore de preparation de citalopram et de bromhydrate de citalopram
DE60334785D1 (de) * 2002-03-27 2010-12-16 Bando Chemical Ind Neues 1,3,5-tris(arylamino)benzol
CA2381341A1 (fr) * 2002-04-09 2003-10-09 Torcan Chemical Ltd. Methode de preparation et intermediaires connexes pour la synthese de l'escitalopram
FI20021421A0 (fi) * 2002-07-30 2002-07-30 Orion Corp Fermion Valmistusmenetelmä
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
WO2004016602A1 (fr) * 2002-08-14 2004-02-26 Natco Pharma Limited Procede de preparation de citalopram haute purete et de ses sels pharmaceutiquement acceptables
GB2385051B (en) * 2002-08-29 2003-12-24 Max India Ltd Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
US20050137255A1 (en) * 2002-12-23 2005-06-23 H. Lundbeck A/S Crystalline escitalopram hydrobromide and methods for preparing the same
PT1578738E (pt) * 2002-12-23 2008-04-11 Lundbeck & Co As H Bromidrato de escitalopram e um método para a sua preparação
AU2003242990A1 (en) * 2003-01-17 2004-08-13 Pulla Reddy Muddasani Processes for the preparation of escitalopram and its precursor
WO2004071431A2 (fr) * 2003-02-05 2004-08-26 Myriad Genetics, Inc. Composition et methode de traitement de troubles neurodegeneratifs
ITMI20030479A1 (it) * 2003-03-13 2004-09-14 Adorkem Technology S P A Procedimento per la preparazione di un ciano-isobenzofurano.
US7019153B2 (en) * 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
JP2007528857A (ja) * 2003-07-11 2007-10-18 ミリアド ジェネティクス， インコーポレイテッド アルツハイマー病の処置のための薬学的方法、投与レジメンおよび投薬形態
GB0317475D0 (en) * 2003-07-25 2003-08-27 Meditab Specialities Pvt Ltd Product
ITFI20030202A1 (it) * 2003-07-28 2005-01-29 Synteco Spa Processo per la preparazione di derivati del
SG146683A1 (en) * 2003-09-17 2008-10-30 Janssen Pharmaceutica Nv Fused heterocyclic compounds as serotonin receptor modulators
WO2005042473A1 (fr) * 2003-10-28 2005-05-12 Wockhardt Limited Procede ameliore de preparation d'hydrobromure de citalopram
PT1506963E (pt) * 2003-10-28 2005-08-31 Adorkem Technology Spa Processo para a preparacao de citalopram
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
PL1708790T3 (pl) * 2003-12-02 2010-10-29 Pharmaneuroboost N V Zastosowanie pipamperonu oraz antagonisty receptora D2 lub antagonisty receptora serotoniny/dopaminy do leczenia zaburzeń psychotycznych
WO2005060968A1 (fr) 2003-12-11 2005-07-07 Sepracor Inc. Combinaison d'un sedatif et d'un modulateur des neurotransmetteurs, et methodes permettant d'ameliorer la qualite du sommeil et de traiter la depression
CN100569765C (zh) * 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI339651B (en) * 2004-02-12 2011-04-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
US20080119662A1 (en) * 2004-02-16 2008-05-22 Jubilant Organosys Limted One Spot Synthesis of Citalopram from 5-Cyanophthalide
US20050196453A1 (en) * 2004-03-05 2005-09-08 H. Lundbeck A/S Crystalline composition containing escitalopram
ITMI20040717A1 (it) * 2004-04-09 2004-07-09 Adorkem Technology Spa Procedimento chemo-enzimatico per la preparazione dell'escitalopram
US20070293538A1 (en) * 2004-04-13 2007-12-20 Myriad Genetics, Incorporated Pharmaceutical Composition And Methods For Treating Neurodegenerative Disorders
EP1737473A4 (fr) * 2004-04-19 2009-08-26 Noven Therapeutics Llc Combinaisons de lithium et utilisations associees
MXPA06012165A (es) * 2004-04-29 2007-01-17 Keystone Retaining Wall System Chapas para muros, muros de contencion y similares.
WO2006020853A2 (fr) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Composition pharmaceutique et methode de traitement de troubles neurodegeneratifs
WO2006020850A2 (fr) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Composition pharmaceutique et technique de traitement de troubles neurodegeneratifs
WO2006020852A2 (fr) * 2004-08-11 2006-02-23 Myriad Genetics, Inc. Composition pharmaceutique et technique de traitement de troubles neurodegeneratifs
EP2141156A1 (fr) 2004-08-23 2010-01-06 Sun Pharma Global FZE Procédé de préparation du citalopram et de ses énantiomères
US7989645B2 (en) * 2004-08-23 2011-08-02 Sun Pharma Global Fze Process for preparation of citalopram and enantiomers
EP1868434A4 (fr) 2005-03-22 2011-10-26 Azevan Pharmaceuticals Inc Acides beta-lactamylalcanoiques destines au traitement des troubles premenstruels
WO2006103550A1 (fr) * 2005-03-31 2006-10-05 Ranbaxy Laboratories Limited Processus de preparation du citalopram et son intermediaire, le 5-aminophthalide
WO2006116218A1 (fr) * 2005-04-22 2006-11-02 Wyeth Formes cristallines de {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}chlorhydrate amine
US7402687B2 (en) 2005-04-22 2008-07-22 Wyeth Dihydrobenzofuran derivatives and uses thereof
EP1871358A1 (fr) * 2005-04-22 2008-01-02 Wyeth Derives d'alcanamine de benzofuranyle et leurs utilisations comme agonistes 5-ht2c
JP2008538577A (ja) * 2005-04-22 2008-10-30 ワイス ジヒドロベンゾフラン誘導体およびその使用
TWI358407B (en) 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
WO2007008758A2 (fr) 2005-07-08 2007-01-18 Braincells, Inc. Methodes destinees a identifier des agents et des conditions modulant la neurogenese
US20070015832A1 (en) * 2005-07-14 2007-01-18 Myriad Genetics, Incorporated Methods of treating overactive bladder and urinary incontinence
JP5328349B2 (ja) * 2005-07-19 2013-10-30 アゼヴァン ファーマスーティカルズ，インコーポレイテッド ベータ−ラクタミルフェニルアラニン、システイン、およびセリン・バソプレッシン拮抗剤
AU2006272760A1 (en) * 2005-07-22 2007-02-01 Myriad Genetics, Inc. High drug load formulations and dosage forms
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
WO2007047978A2 (fr) 2005-10-21 2007-04-26 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
WO2007053596A1 (fr) 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
CN101309924A (zh) * 2005-11-14 2008-11-19 H.隆德贝克有限公司 依地普仑的制备方法
GB0601286D0 (en) 2006-01-23 2006-03-01 Sandoz Ag Asymmetric synthesis
FR2912057B1 (fr) * 2007-02-07 2009-04-17 Sanofi Aventis Sa Composition pharmaceutique contenant en association le saredutant et un inhibiteur selectif de la recapture de la serotonine ou un inhibiteur de la recapture de la serotonine/norepinephrine
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP1991212A1 (fr) * 2006-03-08 2008-11-19 Braincells, Inc. Modulation de neurogenèse par des agents nootropes
TW200806300A (en) * 2006-03-24 2008-02-01 Wyeth Corp New therapeutic combinations for the treatment of depression
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
EP2021000A2 (fr) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenèse par modulation de l'angiotensine
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
WO2008006099A2 (fr) * 2006-07-07 2008-01-10 Myriad Genetics, Inc. Traitement de troubles psychiatriques
TW200817003A (en) * 2006-07-31 2008-04-16 Sanofi Aventis Pharmaceutical composition comprising, in combination, saredutant and a selective serotonin peuptake inhibitor or a serotonin/norepinephrine reuptake inhibitor
WO2008059514A2 (fr) * 2006-07-31 2008-05-22 Cadila Healthcare Limited Procédé de préparation d'escitalopram
KR20090064418A (ko) * 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
WO2008034032A2 (fr) * 2006-09-14 2008-03-20 Azevan Pharmaceuticals, Inc. Modulateurs du récepteur cannabinoïde de type bêta-lactame
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
JP4927497B2 (ja) * 2006-10-25 2012-05-09 株式会社シスコ 無湿乾燥用ホッパー装置
CN100457747C (zh) * 2006-11-21 2009-02-04 浙江大学 抗抑郁药西酞普兰关键中间体5-氰基苯酞的制备工艺
US20080167363A1 (en) * 2006-12-28 2008-07-10 Braincells, Inc Modulation of Neurogenesis By Melatoninergic Agents
AU2008204800A1 (en) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation of neurogenesis with use of modafinil
DK1988086T4 (en) 2007-04-23 2015-03-02 Synthon Bv Method of dissolving citalopram via its (S) -riched citalopram tartrate compound
NZ580738A (en) * 2007-05-18 2012-02-24 Cipla Ltd Process for the preparation of escitalopram
US20080312318A1 (en) * 2007-06-14 2008-12-18 Protia, Llc Deuterium-enriched escitalopram
EP2017271A1 (fr) 2007-07-06 2009-01-21 Aurobindo Pharma Limited Procédé de préparation d'escitalopram
US8022232B2 (en) * 2007-09-11 2011-09-20 H. Lundbeck A/S Method for manufacture of escitalopram
KR101103118B1 (ko) * 2007-11-02 2012-01-04 동아제약주식회사 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물
WO2009128058A1 (fr) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Produits psycho-pharmaceutiques
EP2116231A1 (fr) 2008-05-07 2009-11-11 Hexal Ag Granulé comprenant de l'oxalate d'escitalopram
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
GR20080100696A (el) 2008-10-23 2010-05-13 Genepharm �.�. Φαρμακοτεχνικη μορφη με βελτιωμενη γευση του φαρμακευτικα αποδεκτου αλατος εσιταλοπραμης
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
MX2012004753A (es) 2009-10-23 2012-09-07 Janssen Pharmaceutica Nv Octahidropirrolo[3,4-c]pirrolos disustituidos como moduladores del receptor de orexina.
CN107007596A (zh) 2010-07-01 2017-08-04 阿泽凡药物公司 用于治疗创伤后应激障碍的方法
WO2013100870A1 (fr) 2011-12-02 2013-07-04 Mahmut Bilgic Nouvelles compositions antipsychotiques
WO2013081567A1 (fr) 2011-12-02 2013-06-06 Mahmut Bilgic Formulations antipsychotiques effervescentes
WO2013110313A1 (fr) * 2012-01-23 2013-08-01 H. Lundbeck A/S Modulateurs allostériques sélectifs du transporteur de la sérotonine
AU2015237253B2 (en) 2014-03-28 2019-11-14 Azevan Pharmaceuticals, Inc. Compositions and methods for treating neurodegenerative diseases
UA125873C2 (uk) * 2016-03-10 2022-06-29 Янссен Фармацевтика Нв Спосіб лікування депресії з використанням антагоністів рецептора орексин-2
MY208313A (en) 2017-09-15 2025-04-30 Azevan Pharmaceuticals Inc Compositions and methods for treating brain injury
KR20220049526A (ko) 2019-07-19 2022-04-21 바이오엑셀 테라퓨틱스 인코포레이티드 비-진정성 덱스메데토미딘 치료 양생법
US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (fr) * 1965-03-18

Also Published As

Publication number Publication date
CA1094087A (fr) 1981-01-20
IE44055L (en) 1977-07-14
FI63754C (fi) 1983-08-10
ATA947276A (de) 1980-04-15
JPS52105162A (en) 1977-09-03
AU509445B2 (en) 1980-05-15
US4136193A (en) 1979-01-23
SE7614201L (sv) 1977-07-15
NL970031I2 (nl) 1997-10-01
NO1996001I1 (no) 1996-01-05
AU2107377A (en) 1978-07-13
FI63754B (fi) 1983-04-29
DK143275B (da) 1981-08-03
NL192451B (nl) 1997-04-01
NL970031I1 (nl) 1997-10-01
FR2338271A1 (fr) 1977-08-12
NL7700244A (nl) 1977-07-18
CH632259A5 (de) 1982-09-30
NO147243B (no) 1982-11-22
IE44055B1 (en) 1981-07-29
NO147243C (no) 1983-03-02
ES454980A1 (es) 1978-04-01
GB1526331A (en) 1978-09-27
ZA7757B (en) 1977-11-30
AT359488B (de) 1980-11-10
FI770073A7 (fr) 1977-07-15
JPS6135986B2 (fr) 1986-08-15
FR2338271B1 (fr) 1982-11-05
CH632258A5 (de) 1982-09-30
NO770109L (no) 1977-07-15
CH626886A5 (fr) 1981-12-15
DK143275C (da) 1982-01-18
DE2657013A1 (de) 1977-07-28
DE2657013C2 (de) 1985-11-14
NL192451C (nl) 1997-08-04
DK13177A (da) 1977-07-15
NZ183001A (en) 1978-06-02
SE429551B (sv) 1983-09-12

Similar Documents

Publication Publication Date Title
BE850401A (fr) Derives de phtalane et procede de preparation
BE849794A (fr) Derives de carbostyrile et leur procede de preparation
BE855273A (fr) Procede de preparation de polyurethannes
BE857854A (fr) Procede de preparation de polyurethanne-urees
BE880844A (fr) Nouveaux derives de peptidyl-arginine-aldehydes et procede de preparation de ceux-ci
FR2349579A1 (fr) Derives de 1,2-dihydronaphtalene et leur procede de preparation
BE856313A (fr) Procede de preparation de benzothiazoles
BE838079A (fr) Derives de tetrahydroisoquinoleine et leur procede de preparation
BE842182A (fr) Lucknomycine et son procede de preparation
BE856220A (fr) Polyether-polyureides et procede de leur preparation
BE853162A (fr) Procede de preparation de chloromethylsilanes
LU78503A1 (fr) Procede de preparation de gamma-pyrones
BE855092A (fr) 3,5,5-trimethylhexanoyl-ferrcene et son procede de preparation
FR2347337A1 (fr) Procede de preparation et de purification de la secretine
FR2351967A1 (fr) Procede de preparation de derives de 3-benzazepines
FR2352830A1 (fr) Derives de la neamine et leur procede de preparation
FR2352821A1 (fr) Nouveaux derives de thiazolorifamycine et leur procede de preparation
BE854314A (fr) Procede de preparation de beta-halo-acetals et de beta-halo-cetals
FR2366259B1 (fr) Procede de preparation de derives de nitroalcanols
BE860707A (fr) Derives de quinolone et leur procede de preparation
FR2348928A1 (fr) Procede de preparation de derives 3-hydroxymethylcephem
FR2311537A1 (fr) Derives de 3-nitropyrazole et leur procede de preparation
FR2309230A1 (fr) Derives de triazolocycloalkylthiadiazine et leur procede de preparation
FR2335515A1 (fr) Trimethylphosphiniminodimethylmethylenephosphorane et son procede de preparation
RO67301A2 (fr) Procede de preparation de la 9-azidoacridine et de ses derives

Legal Events

Date Code Title Description
CCPA Application for a supplementary protection certificate

Free format text: 093C0064

CCPV Grant of a supplementary protection certificate

Free format text: 093C0064, EXPIRES 20020114

RE20 Patent expired

Owner name: H. LUNDBECK A/S

Effective date: 19970114