BE2015C027I2 - - Google Patents
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- Publication number
- BE2015C027I2 BE2015C027I2 BE2015C027C BE2015C027C BE2015C027I2 BE 2015C027 I2 BE2015C027 I2 BE 2015C027I2 BE 2015C027 C BE2015C027 C BE 2015C027C BE 2015C027 C BE2015C027 C BE 2015C027C BE 2015C027 I2 BE2015C027 I2 BE 2015C027I2
- Authority
- BE
- Belgium
- Prior art keywords
- antibodies
- kdr
- single chain
- chain antibodies
- triabodies
- Prior art date
Links
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 108010003723 Single-Domain Antibodies Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 102000058223 human VEGFA Human genes 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 229940072221 immunoglobulins Drugs 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36178302P | 2002-03-04 | 2002-03-04 | |
| EP03711375A EP1487856B1 (fr) | 2002-03-04 | 2003-03-04 | Anticorps humains specifiques de kdr et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2015C027I2 true BE2015C027I2 (fr) | 2022-05-19 |
Family
ID=27805075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2015C027C BE2015C027I2 (fr) | 2002-03-04 | 2015-05-06 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7498414B2 (fr) |
| EP (3) | EP2298346A3 (fr) |
| JP (3) | JP2005526506A (fr) |
| AT (2) | ATE475431T1 (fr) |
| AU (1) | AU2003213687A1 (fr) |
| BE (1) | BE2015C027I2 (fr) |
| CA (1) | CA2478169C (fr) |
| CY (3) | CY1111141T1 (fr) |
| DE (1) | DE60333554D1 (fr) |
| DK (2) | DK1916001T3 (fr) |
| ES (2) | ES2347543T3 (fr) |
| FR (1) | FR15C0034I2 (fr) |
| HU (1) | HUS1500025I1 (fr) |
| LU (1) | LU92710I2 (fr) |
| PT (2) | PT1487856E (fr) |
| SI (2) | SI1487856T1 (fr) |
| WO (1) | WO2003075840A2 (fr) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60333554D1 (de) * | 2002-03-04 | 2010-09-09 | Imclone Llc | Kdr-spezifische humane antikörper und deren anwendung |
| US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
| EP1711196A4 (fr) | 2003-12-05 | 2011-09-14 | Bristol Myers Squibb Co | Inhibiteurs des recepteurs du facteur de croissance endothelial vasculaire de type 2 |
| KR101333449B1 (ko) * | 2003-12-10 | 2013-11-26 | 메다렉스, 엘.엘.시. | Ip―10 항체 및 그의 용도 |
| ES2533492T3 (es) * | 2004-02-06 | 2015-04-10 | University Of Massachusetts | Anticuerpos contra toxinas de Clostridium difficile y usos de los mismos |
| MXPA06010715A (es) | 2004-03-19 | 2007-05-23 | Imclone Systems Inc | Anticuerpo del receptor del factor de crecimiento humano anti-epidermico. |
| JP4633788B2 (ja) | 2004-04-13 | 2011-02-16 | エフ.ホフマン−ラ ロシュ アーゲー | 抗p−セレクチン抗体 |
| CA2594356C (fr) | 2005-01-05 | 2018-07-17 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. | Domaines immunoglobuline synthetiques a proprietes de liaison elabores dans des regions de la molecule differentes des regions de determination de complementarite |
| US20060234941A1 (en) | 2005-04-15 | 2006-10-19 | The Gov. Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Peptide epitopes of VEGFR-2/KDR that inhibit angiogenesis |
| RU2502523C2 (ru) | 2005-06-17 | 2013-12-27 | Имклоун Элэлси | АНТИТЕЛА ПРОТИВ PDGFRα ДЛЯ ЛЕЧЕНИЯ ВТОРИЧНОЙ ОПУХОЛИ КОСТИ |
| EP1902145A4 (fr) * | 2005-07-13 | 2010-04-14 | Beth Israel Hospital | Méthodes de diagnostic et de traitement d'une réponse inflammatoire |
| EP3168234A1 (fr) * | 2005-12-15 | 2017-05-17 | Medimmune Limited | Combinaison d'un antagoniste de l'angiopoietine 2 et d'un antagoniste du vegf-a et/ou du kdr et/ou du fltl pour le traitement du cancer |
| AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
| JP5537946B2 (ja) | 2006-11-22 | 2014-07-02 | ブリストル−マイヤーズ スクイブ カンパニー | Igf−irを含むチロシンキナーゼ受容体に対する改変タンパク質に基づく標的治療薬 |
| CA2687633A1 (fr) * | 2007-05-24 | 2008-11-27 | Ablynx N.V. | Sequences d'acides amines dirigees contre les recepteurs des facteurs de croissance et polypeptides renfermant ces dernieres, destines au traitement de maladies et affections associees aux facteurs de croissance et a leurs recepteurs |
| KR100883430B1 (ko) * | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
| US8921279B2 (en) | 2007-06-26 | 2014-12-30 | F-Star Biotechnologische Forschungs—und Entwicklungsges. m.b.H | Display of binding agents |
| US10214588B2 (en) * | 2007-07-03 | 2019-02-26 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating CDR and/or FR positions |
| JP2010534469A (ja) * | 2007-07-25 | 2010-11-11 | アストラゼネカ アクチボラグ | Kdr指向性標的化結合物質およびその使用 |
| UY31478A1 (es) | 2007-11-21 | 2009-07-17 | Inhibicion del receptor para la proteina estimulante del macrofago (ron) y métodos para el tratamiento de lo mismo | |
| MX2010008874A (es) | 2008-02-14 | 2010-09-22 | Bristol Myers Squibb Co | Terapeuticos dirigidos a base de proteinas manipuladas que se unen al receptor de factor de crecimiento epidermico. |
| EP2113255A1 (fr) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Immunoglobuline cytotoxique |
| EP2799448A1 (fr) | 2008-05-22 | 2014-11-05 | Bristol-Myers Squibb Company | Protéines de domaine d'échafaudage à base de fribronectine multivalente |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| KR101224468B1 (ko) | 2009-05-20 | 2013-01-23 | 주식회사 파멥신 | 신규한 형태의 이중표적항체 및 그 용도 |
| US20120183547A1 (en) * | 2009-05-27 | 2012-07-19 | Mount Sinai School Of Medicine | Compositions and methods comprising vegfr-2 and vegfr-3 antagonists for the treatment of metastatic disease |
| US8465743B2 (en) | 2009-10-01 | 2013-06-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-vascular endothelial growth factor receptor-2 chimeric antigen receptors and use of same for the treatment of cancer |
| WO2011090648A2 (fr) * | 2009-12-29 | 2011-07-28 | Yale University | Inhibiteurs des récepteurs du facteur de croissance de l'endothélium vasculaire (vegf) et procédés pour les utiliser |
| US9328162B2 (en) | 2010-02-25 | 2016-05-03 | Schepens Eye Research Institute | Therapeutic compositions for the treatment of dry eye disease |
| WO2011150133A2 (fr) | 2010-05-26 | 2011-12-01 | Bristol-Myers Squibb Company | Protéines d'échafaudage à base de fibronectine ayant une stabilité améliorée |
| WO2012019168A2 (fr) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Acides nucléiques modifiés et leurs procédés d'utilisation |
| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
| WO2012138997A1 (fr) | 2011-04-07 | 2012-10-11 | Amgen Inc. | Nouvelles protéines de liaison d'egfr |
| SG10201604493TA (en) | 2011-06-02 | 2016-07-28 | Dyax Corp | Fc RECEPTOR BINDING PROTEINS |
| HK1199883A1 (en) | 2011-08-26 | 2015-07-24 | Merrimack Pharmaceuticals, Inc. | Tandem fc bispecific antibodies |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2648950C2 (ru) | 2011-10-03 | 2018-04-02 | Модерна Терапьютикс, Инк. | Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение |
| RU2014122184A (ru) | 2011-11-02 | 2015-12-10 | Апексиджен, Инк. | Антитела к kdr и способы их применения |
| AU2012352180A1 (en) | 2011-12-16 | 2014-07-31 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2013151663A1 (fr) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Polynucléotides modifiés pour la production de protéines membranaires |
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| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2903647B1 (fr) * | 2012-10-05 | 2020-01-01 | Kadmon Corporation, LLC | Anticorps humains anti-vegfr-2/kdr |
| CN104870476B (zh) | 2012-11-21 | 2018-04-13 | 药物抗体公司 | 靶向vegfr‑2和dll4的双靶向抗体及包含它的药物组合物 |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| JPWO2014098176A1 (ja) | 2012-12-21 | 2017-01-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体のアモルファス及びその製造方法 |
| ES2774964T3 (es) | 2013-02-04 | 2020-07-23 | Vascular Biogenics Ltd | Métodos para inducir la capacidad de respuesta a un agente antiangiogénico |
| CA2901226C (fr) | 2013-02-18 | 2020-11-17 | Vegenics Pty Limited | Proteines liant le facteur de croissance de l'endothelium vasculaire |
| US9618523B2 (en) | 2013-02-28 | 2017-04-11 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for determining isomeric analytes |
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| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| CN105264380B (zh) | 2013-05-14 | 2017-09-05 | 卫材R&D管理有限公司 | 用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志 |
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| KR20160067219A (ko) | 2013-10-03 | 2016-06-13 | 모더나 세라퓨틱스, 인코포레이티드 | 저밀도 지단백질 수용체를 암호화하는 폴리뉴클레오타이드 |
| KR102127408B1 (ko) * | 2014-01-29 | 2020-06-29 | 삼성전자주식회사 | 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체 |
| TWI558399B (zh) | 2014-02-26 | 2016-11-21 | 美國禮來大藥廠 | 癌症之組合療法 |
| TW201622744A (zh) | 2014-03-04 | 2016-07-01 | 美國禮來大藥廠 | 癌症之組合療法 |
| CA2949121A1 (fr) | 2014-05-15 | 2015-11-19 | Bristol-Myers Squibb Company | Traitement du cancer du poumon a l'aide d'une combinaison d'un anticorps anti-pd-1 et d'un autre agent anticancereux |
| TWI569808B (zh) | 2014-08-15 | 2017-02-11 | 禮來大藥廠 | 肝細胞腫瘤(hcc)之治療 |
| SMT202200367T1 (it) | 2014-08-28 | 2022-11-18 | Eisai R&D Man Co Ltd | Derivato di chinolina a elevata purezza e metodo per la produzione dello stesso |
| WO2016057726A2 (fr) | 2014-10-07 | 2016-04-14 | Kadmon Corporation, Llc | Anticorps humains anti-vegfr-2/kdr |
| TW201625304A (zh) | 2014-10-24 | 2016-07-16 | 美國禮來大藥廠 | 泌尿上皮癌之療法 |
| TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Erk抑制劑 |
| CA2976325C (fr) | 2015-02-25 | 2023-07-04 | Eisai R&D Management Co., Ltd. | Procede de suppression de l'amertume d'un derive de quinoleine |
| KR102662228B1 (ko) | 2015-03-04 | 2024-05-02 | 머크 샤프 앤드 돔 코포레이션 | 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합 |
| US20180155429A1 (en) | 2015-05-28 | 2018-06-07 | Bristol-Myers Squibb Company | Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody |
| US11078278B2 (en) | 2015-05-29 | 2021-08-03 | Bristol-Myers Squibb Company | Treatment of renal cell carcinoma |
| TW201711702A (zh) | 2015-06-04 | 2017-04-01 | 應克隆公司 | 使用針對纖維母細胞生長因子受體3(fgfr3)之化合物的療法 |
| CN107801379B (zh) | 2015-06-16 | 2021-05-25 | 卫材R&D管理有限公司 | 抗癌剂 |
| RS61532B1 (sr) | 2015-07-14 | 2021-04-29 | Bristol Myers Squibb Co | Postupak lečenja kancera primenom inhibitora imunološke kontrolne tačke; antitelo koje se vezuje za receptor programirane smrti-1 (pd-1) ili ligand programirane smrti-1 (pd-l1) |
| TW201716439A (zh) | 2015-07-20 | 2017-05-16 | 美國禮來大藥廠 | Her3抗體 |
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| TW201736399A (zh) * | 2015-12-31 | 2017-10-16 | 財團法人生物技術開發中心 | 抗vegfr抗體及其應用 |
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| JP2019513767A (ja) | 2016-04-15 | 2019-05-30 | イーライ リリー アンド カンパニー | マントル細胞リンパ腫の治療における使用のためのラムシルマブ及びアベマシクリブの組み合わせ療法 |
| JP7169195B2 (ja) | 2016-05-20 | 2022-11-10 | バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド | 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用 |
| JP2019517507A (ja) | 2016-06-03 | 2019-06-24 | イムクローン リミテッド ライアビリティ カンパニー | 特定の癌の治療のためのラムシルマブとペンブロリズマブとの組み合わせ |
| WO2018069871A2 (fr) * | 2016-10-13 | 2018-04-19 | Sorrento Therapeutics, Inc. | Protéines de liaison anti-kras |
| US20200062850A1 (en) | 2016-10-28 | 2020-02-27 | Imclone Llc | Combination of an anti-vegfr-2 antibody and an anti-pd-l1 antibody for the treatment of cancer |
| AU2017363309A1 (en) * | 2016-11-23 | 2019-07-11 | Bioverativ Therapeutics Inc. | Mono- and bispecific antibodies binding to coagulation factor IX and coagulation factor X |
| US10537637B2 (en) | 2017-01-05 | 2020-01-21 | Gensun Biopharma Inc. | Checkpoint regulator antagonists |
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- 2003-03-04 DE DE60333554T patent/DE60333554D1/de not_active Expired - Lifetime
- 2003-03-04 ES ES03711375T patent/ES2347543T3/es not_active Expired - Lifetime
- 2003-03-04 PT PT03711375T patent/PT1487856E/pt unknown
- 2003-03-04 ES ES07023361T patent/ES2362931T3/es not_active Expired - Lifetime
- 2003-03-04 AT AT03711375T patent/ATE475431T1/de active
- 2003-03-04 CA CA2478169A patent/CA2478169C/fr not_active Expired - Lifetime
- 2003-03-04 EP EP10183791A patent/EP2298346A3/fr not_active Withdrawn
- 2003-03-04 EP EP07023361A patent/EP1916001B1/fr not_active Expired - Lifetime
- 2003-03-04 JP JP2003574116A patent/JP2005526506A/ja active Pending
- 2003-03-04 DK DK07023361.4T patent/DK1916001T3/da active
- 2003-03-04 SI SI200331888T patent/SI1487856T1/sl unknown
- 2003-03-04 WO PCT/US2003/006459 patent/WO2003075840A2/fr not_active Ceased
- 2003-03-04 AU AU2003213687A patent/AU2003213687A1/en not_active Abandoned
- 2003-03-04 US US10/506,997 patent/US7498414B2/en active Active
- 2003-03-04 SI SI200332035T patent/SI1916001T1/sl unknown
- 2003-03-04 DK DK03711375.0T patent/DK1487856T3/da active
- 2003-03-04 AT AT07023361T patent/ATE510561T1/de active
- 2003-03-04 PT PT07023361T patent/PT1916001E/pt unknown
- 2003-03-04 EP EP03711375A patent/EP1487856B1/fr not_active Expired - Lifetime
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2008
- 2008-09-19 US US12/234,203 patent/US8057791B2/en not_active Expired - Lifetime
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2009
- 2009-03-26 JP JP2009076394A patent/JP4970483B2/ja not_active Expired - Lifetime
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2010
- 2010-08-30 CY CY20101100793T patent/CY1111141T1/el unknown
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2012
- 2012-02-23 JP JP2012036968A patent/JP5476404B2/ja not_active Expired - Lifetime
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- 2015-04-28 HU HUS1500025C patent/HUS1500025I1/hu unknown
- 2015-04-30 CY CY2015018C patent/CY2015018I1/el unknown
- 2015-05-06 FR FR15C0034C patent/FR15C0034I2/fr active Active
- 2015-05-06 LU LU92710C patent/LU92710I2/fr unknown
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