AU2022369036A1 - A synthesis scheme and procedures for preparing a sik3 inhibitor and intermediates thereof - Google Patents
A synthesis scheme and procedures for preparing a sik3 inhibitor and intermediates thereof Download PDFInfo
- Publication number
- AU2022369036A1 AU2022369036A1 AU2022369036A AU2022369036A AU2022369036A1 AU 2022369036 A1 AU2022369036 A1 AU 2022369036A1 AU 2022369036 A AU2022369036 A AU 2022369036A AU 2022369036 A AU2022369036 A AU 2022369036A AU 2022369036 A1 AU2022369036 A1 AU 2022369036A1
- Authority
- AU
- Australia
- Prior art keywords
- compound
- equiv
- preparing
- formula
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21203530 | 2021-10-19 | ||
| EP21203530.7 | 2021-10-19 | ||
| PCT/EP2022/079131 WO2023067021A1 (fr) | 2021-10-19 | 2022-10-19 | Schéma de synthèse et procédures de préparation d'un inhibiteur de sik3 et d'intermédiaires de celui-ci |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2022369036A1 true AU2022369036A1 (en) | 2024-05-02 |
Family
ID=79231044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2022369036A Pending AU2022369036A1 (en) | 2021-10-19 | 2022-10-19 | A synthesis scheme and procedures for preparing a sik3 inhibitor and intermediates thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250296928A1 (fr) |
| EP (1) | EP4419521A1 (fr) |
| JP (1) | JP2024539268A (fr) |
| KR (1) | KR20240115232A (fr) |
| CN (1) | CN118369321A (fr) |
| AU (1) | AU2022369036A1 (fr) |
| CA (1) | CA3234823A1 (fr) |
| IL (1) | IL312288A (fr) |
| MX (1) | MX2024004690A (fr) |
| WO (1) | WO2023067021A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3643713B1 (fr) | 2018-10-23 | 2025-07-30 | iOmx Therapeutics AG | Inhibiteurs de kinase hétérocycliques et leurs utilisations |
| CN116813608B (zh) * | 2023-06-08 | 2024-03-22 | 英矽智能科技(上海)有限公司 | 噻唑类化合物及其应用 |
| EP4643861A1 (fr) | 2024-04-30 | 2025-11-05 | iOmx Therapeutics AG | Inhibiteur de kinase heteroaryle halogenee destine au traitement du sarcome des tissus mous et des tumeurs vasculaires |
| WO2025229127A1 (fr) | 2024-04-30 | 2025-11-06 | Iomx Therapeutics Ag | Inhibiteur de kinase hétéroaryle halogéné pour le traitement d'un sarcome de tissu mou et de tumeurs vasculaires |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101812060B (zh) * | 2010-02-02 | 2011-08-17 | 南京卡文迪许生物工程技术有限公司 | 一种简捷制备高纯度达沙替尼的新方法以及中间体化合物 |
| AU2015300782B2 (en) | 2014-08-08 | 2020-04-16 | Dana-Farber Cancer Institute, Inc. | Uses of salt-inducible kinase (SIK) inhibitors |
| CN111163771B (zh) | 2017-02-28 | 2023-07-14 | 通用医疗公司 | 嘧啶并嘧啶酮类作为sik抑制剂的用途 |
| DK3391907T3 (da) | 2017-04-20 | 2020-03-09 | Iomx Therapeutics Ag | Intracellulær kinase sik3, der er associeret med resistens over for antitumorimmunresponser, og anvendelser deraf |
| EP3643713B1 (fr) * | 2018-10-23 | 2025-07-30 | iOmx Therapeutics AG | Inhibiteurs de kinase hétérocycliques et leurs utilisations |
| EP3901151A1 (fr) * | 2020-04-21 | 2021-10-27 | iOmx Therapeutics AG | Hétéroaryle halogéné et autres inhibiteurs de kinase hétérocycliques et leurs utilisations |
| WO2021219731A2 (fr) * | 2020-04-28 | 2021-11-04 | Iomx Therapeutics Ag | Inhibiteurs de kinase bicycliques et leurs utilisations |
-
2022
- 2022-10-19 CN CN202280081451.5A patent/CN118369321A/zh active Pending
- 2022-10-19 CA CA3234823A patent/CA3234823A1/fr active Pending
- 2022-10-19 AU AU2022369036A patent/AU2022369036A1/en active Pending
- 2022-10-19 JP JP2024524581A patent/JP2024539268A/ja active Pending
- 2022-10-19 WO PCT/EP2022/079131 patent/WO2023067021A1/fr not_active Ceased
- 2022-10-19 IL IL312288A patent/IL312288A/en unknown
- 2022-10-19 MX MX2024004690A patent/MX2024004690A/es unknown
- 2022-10-19 US US18/702,686 patent/US20250296928A1/en active Pending
- 2022-10-19 EP EP22808682.3A patent/EP4419521A1/fr active Pending
- 2022-10-19 KR KR1020247016088A patent/KR20240115232A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3234823A1 (fr) | 2023-04-27 |
| WO2023067021A1 (fr) | 2023-04-27 |
| EP4419521A1 (fr) | 2024-08-28 |
| CN118369321A (zh) | 2024-07-19 |
| KR20240115232A (ko) | 2024-07-25 |
| US20250296928A1 (en) | 2025-09-25 |
| IL312288A (en) | 2024-06-01 |
| JP2024539268A (ja) | 2024-10-28 |
| MX2024004690A (es) | 2024-07-10 |
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