AU2007263712B2 - Piperazinyl derivatives useful in the treatment of GPR38 receptor mediated diseases - Google Patents

Piperazinyl derivatives useful in the treatment of GPR38 receptor mediated diseases Download PDF

Info

Publication number: AU2007263712B2
Authority: AU; Australia
Prior art keywords: methyl; phenyl; pyridinecarboxamide; fluorophenyl; piperazinyl
Prior art date: 2006-06-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

AU2007263712A

Other languages

English (en)

Other versions

AU2007263712A1 (en

Inventor

Samantha Louisa Brown

Darren Jason Mitchell

Jonathan Thomas Seal

Mervyn Thompson

Susan Marie Westaway

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-06-28

Filing date

2007-06-26

Publication date

2012-08-30

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38476358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2007263712(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-28 Priority claimed from GB0612844A external-priority patent/GB0612844D0/en

2007-06-14 Priority claimed from GB0711525A external-priority patent/GB0711525D0/en

2007-06-26 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2008-01-03 Publication of AU2007263712A1 publication Critical patent/AU2007263712A1/en

2012-08-30 Application granted granted Critical

2012-08-30 Publication of AU2007263712B2 publication Critical patent/AU2007263712B2/en

Status Ceased legal-status Critical Current

2027-06-26 Anticipated expiration legal-status Critical

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AU2007263712A 2006-06-28 2007-06-26 Piperazinyl derivatives useful in the treatment of GPR38 receptor mediated diseases Ceased AU2007263712B2 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB0612844A GB0612844D0 (en)	2006-06-28	2006-06-28	Compounds
GB0612844.1		2006-06-28
GB0711525.6		2007-06-14
GB0711525A GB0711525D0 (en)	2007-06-14	2007-06-14	Compounds
PCT/EP2007/056342 WO2008000729A1 (fr)	2006-06-28	2007-06-26	Dérivés de pipérazinyle utiles dans le traitement de maladies induites par le récepteur gpr38

Publications (2)

Publication Number	Publication Date
AU2007263712A1 AU2007263712A1 (en)	2008-01-03
AU2007263712B2 true AU2007263712B2 (en)	2012-08-30

Family

ID=38476358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2007263712A Ceased AU2007263712B2 (en)	2006-06-28	2007-06-26	Piperazinyl derivatives useful in the treatment of GPR38 receptor mediated diseases

Country Status (29)

Country	Link
US (2)	US7700599B2 (fr)
EP (1)	EP2041093B1 (fr)
JP (1)	JP5028484B2 (fr)
KR (1)	KR20090031688A (fr)
AR (1)	AR061656A1 (fr)
AT (1)	ATE465150T1 (fr)
AU (1)	AU2007263712B2 (fr)
BR (1)	BRPI0713443A2 (fr)
CA (1)	CA2655540A1 (fr)
CR (1)	CR10497A (fr)
CY (1)	CY1110190T1 (fr)
DE (1)	DE602007006019D1 (fr)
DK (1)	DK2041093T3 (fr)
EA (1)	EA015820B1 (fr)
ES (1)	ES2344484T3 (fr)
HR (1)	HRP20100284T1 (fr)
IL (1)	IL195900A0 (fr)
JO (1)	JO2645B1 (fr)
MA (1)	MA30539B1 (fr)
MX (1)	MX2009000110A (fr)
MY (1)	MY147677A (fr)
NO (1)	NO20090266L (fr)
NZ (1)	NZ573450A (fr)
PE (1)	PE20080345A1 (fr)
PL (1)	PL2041093T3 (fr)
PT (1)	PT2041093E (fr)
SI (1)	SI2041093T1 (fr)
TW (1)	TWI391386B (fr)
WO (1)	WO2008000729A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0611907D0 (en) *	2006-06-15	2006-07-26	Glaxo Group Ltd	Compounds
MY150098A (en) *	2005-07-26	2013-11-29	Glaxo Group Ltd	Benzylpiperazine derivates and their medical use
GB0524814D0 (en)	2005-12-05	2006-01-11	Glaxo Group Ltd	Compounds
SI2041093T1 (sl) *	2006-06-28	2010-07-30	Glaxo Group Ltd	Derivati piperazinila, uporabni pri zdravljenju bolezni, ki jih posreduje receptor gpr38
GB0723317D0 (en) *	2007-11-28	2008-01-09	Glaxo Group Ltd	Compounds
US8697877B2 (en)	2009-02-27	2014-04-15	Raqualia Pharma Inc.	Oxyindole derivatives with motilin receptor agonistic activity
US9452980B2 (en) *	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
WO2011092293A2 (fr)	2010-02-01	2011-08-04	Novartis Ag	Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf
CN102762572A (zh)	2010-02-01	2012-10-31	诺瓦提斯公司	作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
CN102753527B (zh)	2010-02-02	2014-12-24	诺华股份有限公司	用作crf受体拮抗剂的环己基酰胺衍生物
PT2623492E (pt)	2010-09-27	2014-08-29	Daiichi Sankyo Co Ltd	Composto derivado de ciclo-hexano
US9321727B2 (en) *	2011-06-10	2016-04-26	Hoffmann-La Roche Inc.	Pyridine derivatives as agonists of the CB2 receptor
EP3757102A1 (fr)	2016-03-17	2020-12-30	F. Hoffmann-La Roche AG	Dérivé de 5-éthyl-4-méthyl-pyrazole-3-carboxamide ayant une activité comme agonist de taar
TWI794994B (zh) *	2020-09-25	2023-03-01	大陸商上海美悅生物科技發展有限公司	嘧啶甲醯胺類化合物及其應用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030203922A1 (en) *	2001-01-12	2003-10-30	Amgen Inc.	Substituted amine derivatives and methods of use
WO2007012479A2 (fr) *	2005-07-26	2007-02-01	Glaxo Group Limited	Composes

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5385912A (en) *	1991-03-08	1995-01-31	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
TW355711B (en)	1992-11-04	1999-04-11	Chugai Pharmaceutical Co Ltd	Erythromycin derivatives
JPH06211886A (ja)	1992-11-04	1994-08-02	Chugai Pharmaceut Co Ltd	エリスロマイシン誘導体
US5593994A (en) *	1994-09-29	1997-01-14	The Dupont Merck Pharmaceutical Company	Prostaglandin synthase inhibitors
JP3901239B2 (ja)	1996-03-13	2007-04-04	大正製薬株式会社	アリールアルカン誘導体
US5965578A (en) *	1996-04-03	1999-10-12	Merck & Co., Inc.	Inhibitors of farnesyl-protein transferase
DE19644195A1 (de)	1996-10-24	1998-04-30	Solvay Pharm Gmbh	10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
AU4968997A (en) *	1996-11-26	1998-06-22	Chugai Seiyaku Kabushiki Kaisha	13-membered ring macrolide compounds, medicine containing the same, and process for producing the same
US6060491A (en) *	1997-06-19	2000-05-09	Dupont Pharmaceuticals	6-membered aromatics as factor Xa inhibitors
US5972939A (en) *	1997-10-28	1999-10-26	Ortho-Mcneil Pharmaceutical, Inc.	Cyclopentene derivatives useful as antagonists of the motilin receptor
DE19805822B4 (de)	1998-02-13	2009-02-05	Solvay Pharmaceuticals Gmbh	11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en)	1998-02-13	2000-12-26	Solvay Pharmaceuticals Gmbh	11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
GB9804734D0 (en) *	1998-03-05	1998-04-29	Pfizer Ltd	Compounds
PL215901B1 (pl) *	1999-04-15	2014-02-28	Bristol Myers Squibb Co	Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek
US20020052380A1 (en) *	2000-02-18	2002-05-02	Dinsmore Christopher J.	Inhibitors of prenyl-protein transferase
US20020010184A1 (en) *	2000-02-18	2002-01-24	Dinsmore Christopher J.	Inhibitors of prenyl-protein transferase
AU2001249144A1 (en) *	2000-03-13	2001-09-24	Ortho-Mcneil Pharmaceutical, Inc.	Novel cyclopentene derivatives useful as antagonists of the motilin receptor
US6423714B2 (en) *	2000-03-13	2002-07-23	Ortho Mcneil-Pharmaceutical, Inc..	Cyclohexene derivatives useful as antagonists of the motilin receptor
US6384031B2 (en) *	2000-03-13	2002-05-07	Ortho-Mcneil Pharmaceutical, Inc.	Cyclobutene derivatives useful as antagonists of the motilin receptor
US6511980B2 (en) *	2000-05-05	2003-01-28	Ortho Mcneil Pharmaceutical, Inc.	Substituted diamine derivatives useful as motilin antagonists
GB0013378D0 (en) *	2000-06-01	2000-07-26	Glaxo Group Ltd	Use of therapeutic benzamide derivatives
US7105682B2 (en) *	2001-01-12	2006-09-12	Amgen Inc.	Substituted amine derivatives and methods of use
US6878714B2 (en) *	2001-01-12	2005-04-12	Amgen Inc.	Substituted alkylamine derivatives and methods of use
EP1392679B1 (fr)	2001-05-10	2005-11-02	Solvay Pharmaceuticals GmbH	Nouveaux derives de 1-amidomethylcarbonyl-piperidine, procede pour produire ces composes et medicaments contenant ces composes
US6977264B2 (en) *	2001-07-25	2005-12-20	Amgen Inc.	Substituted piperidines and methods of use
GB0129013D0 (en) *	2001-12-04	2002-01-23	Glaxo Group Ltd	Compounds
GB0129015D0 (en) *	2001-12-04	2002-01-23	Glaxo Group Ltd	Compounds
SE0203302D0 (sv) *	2002-11-07	2002-11-07	Astrazeneca Ab	Novel Compounds
US7223788B2 (en) *	2003-02-14	2007-05-29	Sanofi-Aventis Deutschland Gmbh	Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
US7338954B2 (en)	2003-09-17	2008-03-04	Bristol-Myers Squibb Company	Compounds useful as motilin agonists and method
US7262195B2 (en)	2003-09-17	2007-08-28	Bristol-Myers Squibb Company	Compounds useful as motilin agonists and method
AU2004278352B2 (en) *	2003-10-01	2008-10-30	The Procter & Gamble Company	Melanin concentrating hormone antagonists
WO2005063720A1 (fr) *	2003-12-25	2005-07-14	Nippon Shinyaku Co., Ltd.	Derive d'amide et medicament
WO2005077345A1 (fr)	2004-02-03	2005-08-25	Astrazeneca Ab	Composes pour le traitement de la maladie du reflux gastro-oesophagien
WO2005077368A2 (fr)	2004-02-03	2005-08-25	Astrazeneca Ab	Nouveau traitement du reflux gastro-oesophagien pathologique iii
WO2005077373A2 (fr)	2004-02-03	2005-08-25	Astrazeneca Ab	Nouveau traitement du reflux gastro-oesophagien pathologique ii
US20050277629A1 (en) *	2004-03-18	2005-12-15	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies (Lansbury)
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
SE0401345D0 (sv)	2004-05-25	2004-05-25	Astrazeneca Ab	Therapeutic compounds: Pyridine as scaffold
GB0611907D0 (en)	2006-06-15	2006-07-26	Glaxo Group Ltd	Compounds
JP2009501199A (ja)	2005-07-12	2009-01-15	グラクソグループリミテッド	Ｇｐｒ３８アゴニストとしてのピペラジンヘテロアリール誘導体
SI2041093T1 (sl) *	2006-06-28	2010-07-30	Glaxo Group Ltd	Derivati piperazinila, uporabni pri zdravljenju bolezni, ki jih posreduje receptor gpr38

2007
- 2007-06-26 SI SI200730257T patent/SI2041093T1/sl unknown
- 2007-06-26 CA CA002655540A patent/CA2655540A1/fr not_active Abandoned
- 2007-06-26 US US11/768,339 patent/US7700599B2/en not_active Expired - Fee Related
- 2007-06-26 EA EA200970065A patent/EA015820B1/ru not_active IP Right Cessation
- 2007-06-26 JO JO2007261A patent/JO2645B1/en active
- 2007-06-26 DE DE602007006019T patent/DE602007006019D1/de active Active
- 2007-06-26 AT AT07765616T patent/ATE465150T1/de active
- 2007-06-26 PL PL07765616T patent/PL2041093T3/pl unknown
- 2007-06-26 EP EP07765616A patent/EP2041093B1/fr active Active
- 2007-06-26 AU AU2007263712A patent/AU2007263712B2/en not_active Ceased
- 2007-06-26 PE PE2007000819A patent/PE20080345A1/es not_active Application Discontinuation
- 2007-06-26 NZ NZ573450A patent/NZ573450A/en not_active IP Right Cessation
- 2007-06-26 MX MX2009000110A patent/MX2009000110A/es active IP Right Grant
- 2007-06-26 HR HR20100284T patent/HRP20100284T1/hr unknown
- 2007-06-26 WO PCT/EP2007/056342 patent/WO2008000729A1/fr not_active Ceased
- 2007-06-26 DK DK07765616.3T patent/DK2041093T3/da active
- 2007-06-26 JP JP2009517160A patent/JP5028484B2/ja not_active Expired - Fee Related
- 2007-06-26 ES ES07765616T patent/ES2344484T3/es active Active
- 2007-06-26 KR KR1020087031612A patent/KR20090031688A/ko not_active Ceased
- 2007-06-26 PT PT07765616T patent/PT2041093E/pt unknown
- 2007-06-26 TW TW096122969A patent/TWI391386B/zh not_active IP Right Cessation
- 2007-06-26 BR BRPI0713443-6A patent/BRPI0713443A2/pt not_active IP Right Cessation
- 2007-06-26 AR ARP070102835A patent/AR061656A1/es not_active Application Discontinuation
2008
- 2008-12-11 CR CR10497A patent/CR10497A/es not_active Application Discontinuation
- 2008-12-11 IL IL195900A patent/IL195900A0/en unknown
- 2008-12-24 MY MYPI20085319A patent/MY147677A/en unknown
- 2008-12-30 MA MA31526A patent/MA30539B1/fr unknown
2009
- 2009-01-16 NO NO20090266A patent/NO20090266L/no not_active Application Discontinuation
- 2009-04-02 US US12/417,176 patent/US8853218B2/en not_active Expired - Fee Related
2010
- 2010-06-11 CY CY20101100521T patent/CY1110190T1/el unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030203922A1 (en) *	2001-01-12	2003-10-30	Amgen Inc.	Substituted amine derivatives and methods of use
WO2007012479A2 (fr) *	2005-07-26	2007-02-01	Glaxo Group Limited	Composes

Also Published As

Publication number	Publication date
MX2009000110A (es)	2009-01-23
MA30539B1 (fr)	2009-06-01
TWI391386B (zh)	2013-04-01
JO2645B1 (en)	2012-06-17
BRPI0713443A2 (pt)	2012-03-06
ES2344484T3 (es)	2010-08-27
NO20090266L (no)	2009-03-17
PL2041093T3 (pl)	2010-09-30
DK2041093T3 (da)	2010-08-02
US8853218B2 (en)	2014-10-07
AR061656A1 (es)	2008-09-10
AU2007263712A1 (en)	2008-01-03
CA2655540A1 (fr)	2008-01-03
JP2009541432A (ja)	2009-11-26
US7700599B2 (en)	2010-04-20
US20080027065A1 (en)	2008-01-31
PT2041093E (pt)	2010-06-28
CY1110190T1 (el)	2015-01-14
HK1127608A1 (en)	2009-10-02
HRP20100284T1 (hr)	2010-06-30
US20090192160A1 (en)	2009-07-30
TW200817352A (en)	2008-04-16
EP2041093B1 (fr)	2010-04-21
ATE465150T1 (de)	2010-05-15
KR20090031688A (ko)	2009-03-27
EA200970065A1 (ru)	2009-06-30
WO2008000729A1 (fr)	2008-01-03
IL195900A0 (en)	2009-09-01
EA015820B1 (ru)	2011-12-30
NZ573450A (en)	2011-11-25
MY147677A (en)	2012-12-31
DE602007006019D1 (de)	2010-06-02
CR10497A (es)	2009-03-20
SI2041093T1 (sl)	2010-07-30
JP5028484B2 (ja)	2012-09-19
PE20080345A1 (es)	2008-05-29
EP2041093A1 (fr)	2009-04-01

Publication	Publication Date	Title
AU2007263712B2 (en)	2012-08-30	Piperazinyl derivatives useful in the treatment of GPR38 receptor mediated diseases
JP3390744B2 (ja)	2003-03-31	シアノフェニル誘導体
JP5232143B2 (ja)	2013-07-10	モチリン受容体アンタゴニストとしてのベンジルピペラジン誘導体
JPH09504004A (ja)	1997-04-22	５ｈｔ１ｄレセプター拮抗薬用アミドおよび尿素誘導体
CA2558243A1 (fr)	2005-09-22	Inhibiteurs d'histone desacetylase
US7964597B2 (en)	2011-06-21	Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases
US7964602B2 (en)	2011-06-21	Biaryl compounds useful as agonists of the Gpr38 receptor
AU8630998A (en)	1999-01-04	Angiogenesis inhibiting 5-substituted-1,2,4-thiadiazolyl derivatives
CN101511791B (zh)	2012-06-20	用于治疗gpr38受体介导的疾病的哌嗪基衍生物
HK1127608B (en)	2010-07-23	Piperazinyl derivatives useful in the treatment of gpr38 receptor mediated diseases
JPS60237082A (ja)	1985-11-25	アミン誘導体およびその塩
JPH0193568A (ja)	1989-04-12	アミド化合物、及びそれを有効成分とする消化管運動賦活剤
JP2003137873A (ja)	2003-05-14	シアノフェニル誘導体

Legal Events

Date	Code	Title	Description
2013-01-10	FGA	Letters patent sealed or granted (standard patent)
2015-01-29	MK14	Patent ceased section 143(a) (annual fees not paid) or expired