AU2006313701A1

AU2006313701A1 - Novel pyridopyrazines and their use as modulators of kinases

Info

Publication number: AU2006313701A1
Application number: AU2006313701A
Authority: AU
Inventors: Eckhard Claus; Michael Czech; Eckhard Gunther; Emmanuel Polymeropoulos; Tilmann Schuster; Irene Seipelt
Original assignee: Aeterna Zentaris GmbH
Current assignee: Aeterna Zentaris GmbH
Priority date: 2005-11-11
Filing date: 2006-11-10
Publication date: 2007-05-18
Anticipated expiration: 2026-11-10
Also published as: JP2009515853A; EP1957487A1; CA2628039A1; JP5527972B2; HK1126474A1; WO2007054556A1; AU2006313701B2; IL191139A0; AR060010A1; KR101400905B1; NO20082511L; KR20080068117A

Description

IN THE MATTER OF an Australian Application corresponding to PCT Application PCT/EP2006/068322 C RWS Group Ltd, of Europa House, Marsham Way, Gerrards Cross, Buckinghamshire, England, hereby solemnly and sincerely declares that, to the best of its knowledge and belief, the following document, prepared by one of its translators competent in the art and conversant with the English and German languages, is a true and correct translation of the PCT Application filed under No. PCT/EP2006/068322. Date: 9 April 2008 - N. T. SIMPKIN Deputy Managing Director - UK Translation Division For and on behalf of RWS Group Ltd IP A', a SYD W02007/054556 PCT/EP2006/068322 Novel pyridopyrazines and their use as modulators of kinases Description 5 Technical field The invention relates to kinase modulators of the pyrido[2,3-b]pyrazine type and to the preparation and use thereof as medicaments for the modulation of misdirected cellular signal transduction processes, in particular for influencing the function of tyrosine kinases, serine/threonine kinases and lipid kinases and for the treatment of 10 malignant or benign oncoses and other disorders based on pathological cell proliferation, for example restenosis, psoriasis, arteriosclerosis and cirrhosis of the liver. State of the art 15 The activation of protein kinases is a central event in cellular signal transduction processes. Aberrant kinase activation is observed in various pathological states. Targeted inhibition of kinases is therefore a fundamental therapeutic aim. The phosphorylation of proteins is generally initiated by extracellular signals and represents a universal mechanism for controlling various cellular events, for example 20 metabolic processes, cell growth, cell migration, cell differentiation, membrane transport and apoptosis. The kinase protein family is responsible for protein phosphorylation. These enzymes catalyse transfer of phosphate to specific substrate proteins. Based on the substrate specificity, the kinases are divided into three main classes, the tyrosine kinases, the serine/threonine kinases and the lipid kinases. Both 25 the receptor tyrosine kinases and the cytoplasmic tyrosine, serine/threonine and lipid kinases are important proteins in cellular signal transduction. Overexpression or degradation of these proteins plays an important part in disorders based on pathological cell proliferations. These include metabolic disorders, disorders of the connective tissue and of the blood vessels, and malignant and benign oncoses. In 30 tumour initiation and development they frequently occur as oncogens, i.e. as aberrant, constitutively active kinase proteins. The consequences of this excessive kinase activation are, for example, uncontrolled cell growth and reduced cell death.

W02007/054556 PCT/EP2006/068322 Stimulation of tumour-induced growth factors may also be the cause of overstimulation of kinases. The development of kinase modulators is therefore of particular interest for all pathogenic processes influenced by kinases. The ras-Raf-Mek-Erk and P13K-Akt signal transduction cascades play a central role 5 in cell growth, cell proliferation, apoptosis, adhesion, migration and glucose metabolism. Thus, the fundamental involvement in the pathogenesis of disorders such as cancer, neurodegeneration and inflammatory disorders has been demonstrated both for the ras-Raf-Mek-Erk and for the P13K-Akt signal pathway. Therefore, the individual components of these signal cascades constitute important therapeutic points of attack 10 for the intervention in the various disease processes (Weinstein-Oppenheimer C.R. et al 2000, Chang F. et al 2003, Katso R. et al 2001 and Lu Y. et al 2003). The molecular and biochemical properties of the two signal pathways will first be described separately below. A multitude of growth factors, cytokines and oncogens transduce their growth 15 promoting signals via the activation of G-protein-coupled ras, which leads to the activation of the serine-threonine kinase Raf and to the activation of the mitogen activated protein kinase kinase 1 and 2 (MAPKK1/2 or Mekl/2), and results in the phosphorylation and activation of MAPK 1 and 2 - also known as extracellular signal regulated kinase (Erk1 and 2). Compared to other single pathways, the ras-Raf-Mek 20 Erk signal pathway combines a large number of proto-oncogens, including ligands, tyrosine kinase receptors, G proteins, kinases and nuclear transcription factors. Tyrosine-kinases, for example EGFR (Mendelsohn J. et al., 2000) mediate, in the course of the tumour process, caused by overexpression and mutation, frequently constitutively active signals to the downstream ras-Raf-Mek-Erk signal pathway. Ras 25 mutations have mutated in 30% of all human tumours (Khleif S.N. et al., 1999, Marshall C., 1999), the highest incidence at 90% being in pancreas carcinomas (Friess H. et al., 1996, Sirivatanauksorn V. et al., 1998). For c-Raf, deregulated expression and/or activation have been described in various tumours (Hoshino R. et al., 1999, McPhillips F. et al., 2001). B-Raf point mutants have been detected in 66% of all human malignant 30 melanomas, 14% of ovarian carcinomas and 12% of colon carcinomas (Davies H. et al., 2002). It is therefore not surprising that Erkl/2 is involved at primary stage in many cellular processes, such as cell growth, cell proliferation and cell differentiation (Lewis T.S. et al., 1998, Chang F. et al., 2003).

W02007/054556 PCT/EP2006/068322 -3 In addition, the members of Raf kinases also have Mek-Erk-independent, anti apoptotic functions whose molecular steps have not yet been described fully. Possible interaction partners described for the Mek-Erk-independent Raf activity have been Ask1, Bcl-2, Akt and Bag1 (Chen J et al., 2001, Troppmaier J. et al., 2003, Rapp U.R. -5 -et al., 2004, Gotz R. et al., 2005). It is now assumed that both Mek-Erk-dependent and Mek-Erk-independent signal transduction mechanisms control the activation of the upstream ras and Raf stimuli. The isoenzymes of the phosphatidylinositol 3-kinases (P13Ks) function primarily as 10 lipid kinases and catalyse the D3 phosphorylation of the second messenger lipids PtdIns (phosphatidylinositol) to Ptdlns(3)P, Ptdlns(3,4)P 2 , PtdIns(3,4,5)P3 phosphatidylinositol phosphates. The P13Ks of class I are composed in structural terms of the catalytic subunit (p11Oalpha, beta, gamma, delta) and of the regulatory subunit (p85alpha, beta or plOlgamma). In addition, the class II (Pl3K-C2alpha, P13K-C2beta) 15 and class Ill (Vps34p) enzymes belong to the family of the P13 kinases (Wymann M.P. et al., 1998, VanHaesebroeck B. et al., 2001). The PIP rise induced by the P13Ks firstly activates the proliferative ras-Raf-Mek-Erk signal pathway via the coupling of ras (Rodriguez-Viciana P. et al., 1994) and secondly stimulates the anti-apoptotic signal pathway by recruiting Akt to the cell membrane and consequently overactivating this 20 kinase (Alessi D.R. et al., 1996, Chang H.W. et al., 1997, Moore S.M. et al., 1998). Thus, the activation of the PI3Ks fulfils at least 2 crucial mechanisms of tumour development, specifically the activation of cell growth and cell differentiation, and the inhibition of apoptosis. In addition, the PI3Ks also have protein-phosphorylating properties (Dhand et al., 1994, Bondeva T. et al., 1998, Bondev A. et al., 1999, 25 VanHaesebroeck B. et al., 1999), which, for example, can induce serine autophosphorylation which intrinsically regulates the PI3Ks. It is also known that PI3Ks have kinase-independent, regulating effector properties, for example in the control of heart contraction (Crackower M.A. et al., 2002, Patrucco et al., 2004). It has also been demonstrated that Pl3Kdelta and Pl3Kgamma are expressed specifically on 30 haematopoietic cells and are thus potential points of attack for isoenzyme-specific PI3Kdelta and Pl3Kgamma inhibitors in the treatment of inflammatory disorders such as rheumatism, asthmas and allergies and in the treatment of B and T cell lymphomas (Okkenhaug K. et al., 2003, Ali K. et al., 2004, Sujobert P. et al., 2005). Pl3Kalpha, which has recently been identified as a proto-oncogen (Shayesteh L. et al., 1999, Ma W02007/054556 PCT/EP2006/068322 -4 Y.Y. et al., 2000, Samuels Y. et al., 2004, Campbell l.G. et al., 2004, Levine D.A., 2005) is an important target in the therapy of tumour disorders. The significance of the P13K species as a target for active ingredient development is therefore extremely wide (Chang F. & Lee J.T. et al, 2003). 5 Of equally great interest are the P13K-related kinases (PIKKs), which include the serine/threonine kinases mTOR, ATM, ATR, h-SMG-1 and DNA-PK (Chiang G.G. et al 2004). Their catalytic domains have a high sequence homology to the catalytic domains of the PI3Ks. 10 Moreover, the loss of the tumour suppressor protein PTEN (Li J. et al., 1997, Steck P.A. et al., 1997) - whose function is the reversal of the phosphorylation initiated by P13K - contributes to overactivation of Akt and its downstream cascade components and hence underlines the causal significance of P13K as a target molecule for tumour therapy. 15 Various inhibitors of individual components of the ras-Raf-Mek-Erk and P13K-Akt signal pathways have already been published and patented. The current state of development in the field of the kinase-inhibitors, particularly of the 20 ras-Raf-Mek-Erk and of the PI3K-Akt pathway, is detailed in the reviews by J.S. Sebolt Leopold et al., 2004, and R. Wetzker et al., 2004. Said publications contain a comprehensive list of the published patents which describe the synthesis and use of low molecular weight ras-Raf-Mek-Erk and P13K inhibitors. 25 The kinase inhibitor Bay 43-9006 (WO 99/32111, WO 03/068223) already in clinical trials exhibits a relatively unspecific inhibition pattern of serine/threonine kinases and of tyrosine kinases such as Raf, VEGFR2/3, Flt-3, PDGFR, c-Kit and further kinases. Great significance is attributed to this inhibitor in advanced tumour disorders induced by angiogenesis (for example in the case of kidney cell carcinoma) but also in the case of 30 melanomas with high B-Raf mutation rate. The clinical action of Bay 43-9006 is currently also being determined in patients having refractory solid tumours in combination, for example, with docetaxel. To date, mild side effects and promising anti-tumour effects W02007/054556 PCT/EP2006/068322 have been described. Inhibition of the kinases in the P13K-Akt signal pathway has neither been described nor disclosed for Bay 43-9006. The Mekl/2 inhibitor PD0325901 (WO 02/06213) is currently in phase I clinical 5 trials. The precursor substance Cl-1040 (WO 00/35435, WO 00/37141) was noticeable by its high Mek specificity and target affinity. However, this compound was found to be metabolically unstable in phase I/1l studies. Clinical data for the current successor substance PD0325901 are still to come. However, neither interaction with Erk1 or Erk2 nor a function inhibiting the P13K-Akt signal pathway or their simultaneous modulation 10 has been published or disclosed for this Mek inhibitor. The P13K inhibitors published to date are still in preclinical trials. ICOS disclosed a P13K inhibitor IC87114 with high P13Kdelta isoenzyme specificity (WO 01/81346). For P1103 (WO 04/017950), Yamanouchi/Piramed describe a selectivity versus the P13Kalpha 15 isoform. Moreover, a highly noted field of research exists in the early development of P13K inhibitors (see review of R. Wetzker et al., 2004). Inhibitors of the SAPK signal pathway, either of Jnk or of p38, are described in the literature (Gum R.J., 1998, Bennett B.L. et al 2001, Davies S.P. et al 2000). However, 20 no function of inhibiting the P13Ks nor any specific inhibition of Erk1 or Erk2 or else any specific inhibition of SAPKs, Erk1, Erk2, or P13Ks has been disclosed for these SAPK inhibitors. 6- or 7-substituted pyrido[2,3-b]pyrazine derivatives find wide use in pharmaceutical 25 chemistry as pharmacologically active compounds and as synthetic units. For example, the patents WO 04/104002 and WO 04/104003 describe pyrido[2,3 b]pyrazines which may be 6- or 7-substituted by urea, thiourea, amidine or guanidine groups. These compounds have properties as inhibitors or modulators of kinases, especially of tyrosine and serine/threonine kinases, and a use as a medicament is 30 reported. In contrast, a use of these compounds as modulators of lipid kinases, alone or in combination with tyrosine and serine/threonine kinases, has not been described.

W02007/054556 PCT/EP2006/068322 Moreover, the patent WO 99/17759 describes pyrido[2,3-b]pyrazines which bear, in the 6-position, inter alia, alkyl-, aryl- and heteroaryl-substituted carbamates. These compounds are intended for use to modulate the function of serine-threonine protein kinases. 5 The patent WO 05/007099 (Kawakami et al.) describes, inter alia, urea-substituted pyrido[2,3-b]pyrazines as inhibitors of the serine/threonine kinase PKB. However, this patent does not further define the R radical, which should describe the range of substitution on the urea, and the range of substitution on the urea is thus not clearly disclosed. For these compounds, use in the treatment of cancer disorders is reported. 10 However, no specific examples of urea-substituted pyridopyrazines having these biological properties are given. In addition, the pyridopyrazines described here differ structurally significantly from the inventive pyrido[2,3-b]pyrazines described in this invention. Further examples of 6- and 7-urea-substituted pyrido[2,3-b]pyrazines are reported 15 in the patent WO 05/056547 (Bemis et al.). However, the compounds in this patent have additional carbonyl, sulphoxy, sulphone or imine substitution in the 2- or 3 position, which means that the compounds differ structurally significantly from the inventive pyrido[2,3-b]pyrazines described in this invention. The pyridopyrazines reported in WO 05/056547 are described as inhibitors of protein kinases, especially of 20 GSK-3, Syk and JAK-3. For these compounds, the uses reported include use in the treatment of proliferative disorders. Use of these compounds as modulators of lipid kinases, alone or in combination with serine/threonine kinases, is not described. The patent WO 04/005472 by White et al. describes, inter alia, 6-carbamate substituted pyrido[2,3-b]pyrazines which, as antibacterial substances, inhibit the growth 25 of bacteria. Antitumour action is not described. Certain diphenylquinoxalines and -pyrido[2,3-b]pyrazines with specific alkylpyrrolidine, alkylpiperidine or alkylsulphonamide radicals on a phenyl ring, which may additionally also bear urea or carbamate substitutions in the 6- or 7-position, are described in the patents WO 03/084473 (Barnett et al.), WO 03/086394 (Bilodeau et 30 al.) and WO 03/086403 (Lindsley et al.) as inhibitors of the activity of the serine/threonine kinase Akt. For these compounds, use in the treatment of cancer disorders is reported. For the pyrido[2,3-b]pyrazine example compounds described there, no defined indication of biological action is specified. Moreover, there is a W02007/054556 PCT/EP2006/068322 -7 significant structural difference from the inventive pyrido[2,3-b]pyrazines described in this invention. Moreover, the patent WO 03/024448 by Delorme et al. describes amide- and acrylamide-substituted pyrido[2,3-b]pyrazines which also contain carbamates as 5 additional substitutents and can be used as histone deacetylase inhibitors for the treatment of cell proliferation disorders. A further publication (C. Temple, Jr.; J. Med. Chem. 1990, 3044-3050) uses an example to describe the synthesis of a 6-ethyl carbamate-substituted pyrido[2,3 b]pyrazine derivative. Antitumour action is neither disclosed nor rendered obvious. 10 The synthesis of further derivatives of the 6-ethyl carbamate-substituted pyrido[2,3 b]pyrazine is described in a publication by R. D. Elliott (J. Org. Chem. 1968, 2393 2397). Biological action of these compounds is neither described nor rendered obvious. The publication by C.Temple, Jr. J. Med. Chem. 1968,1216-1218 describes the synthesis and examination of 6-ethyl carbamate-substituted pyrido[2,3-b]pyrazines as 15 potential active antimalarial ingredients. Antitumour action is neither disclosed nor rendered obvious. Statement of the invention The invention is therefore directed to the provision of novel compounds which are 20 suitable as modulators of receptor tyrosine kinases, of cytoplasmic tyrosine kinases, serine/threonine kinases and lipid kinases. Since not all kinases which are present in series in misregulated signal transduction cascades - for example in the case of Raf Mek-Erk or PI3K-Akt -, need be present as oncogenic kinases or as constitutively active enzymes, this invention also considers the inactive kinases as therapeutic target 25 proteins, i.e. the novel compounds can bind both to active and to inactive kinases and hence influence signal transduction. The invention is also directed to the provision of novel compounds which, as modulators of receptor tyrosine kinases, cytoplasmic tyrosine kinases, serine/threonine kinases and lipid kinases, have the property of influencing either an individual kinase or 30 two or more kinases, especially Erkl/2 and P13K, from one signal transduction cascade or different signal transduction cascades, especially ras-Raf-Mek-Erk and PI3K-Akt. A dual mechanism, i.e. the simultaneous inhibition of two or more signal transduction W02007/054556 PCT/EP2006/0683 22 cascades compared to the therapeutic attack on only one signal transduction pathway, should, by virtue of the additive effect, lead to an increase in the effect in the treatment of all pathogenic processes which are influenced by kinases. 5 It has now been found that, surprisingly, novel compounds from the group of the pyrido[2,3-b]pyrazines which are 6- or 7-substituted, for example by urea or thiourea moieties, are suitable for producing medicaments for modulating misdirected cellular signal transduction processes, especially for influencing the function of receptor tyrosine kinases, cytoplasmic tyrosine kinases, serine/threonine kinases and lipid 10 kinases, and for treating malignant or benign tumour disorders, for example of the breast, prostate, lung, skin, ovaries, and other disorders based on pathological cell proliferations. A first aspect of the present application describes novel compounds from the group 15 of the pyrido[2,3-b]pyrazines of the general formula (1) z 5 Z2 N Z4 Zi N N Z3 20 in which: (A) one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted aryl", where "substituted aryl" is substituted by at least one substituent selected identically or differently from the group consisting of: 25 (a) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-X1, -N(alkyl) 2 , NHC(O)-alkyl, -NHC(O)-cycloalkyl, -NHC(O)-heterocyclyl,

-NHC(O)

aryl, -NHC(O)-heteroaryl, -NHC(O)-arylalkyl, -NHC(O)-heteroarylalkyl, -NHS(0 2 )-alkyl, -NHS(0 2 )-cycloalkyl, -NHS(O 2 )-heterocyclyl, NHS(0 2 )-aryl, -NHS(0 2 )-heteroaryl, -NHS(O 2 )-arylalkyl, -NHS(0 2

)-

W02007/054556 PCT/EP2006/0683 22 heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -O-X2, -OC(O)-alkyl, OC(O)-cycloalkyl, -OC(O)-heterocyclyl, -OC(O)-aryl, -OC(0) heteroaryl, -OC(O)-arylalkyl, -OC(O)-heteroarylalkyl,

-OS(O

2 )-alkyl, OS(0 2 )-cycloalkyl, -OS(0 2 )-heterocyclyl, -OS(0 2 )-aryl, -OS(0 2

)

5 heteroaryl, -OS(0 2 )-arylalkyl, -OS(0 2 )-heteroarylalkyl, -C(0)-alkyl, C(0)-aryl, -C(0)-heteroaryl, -C(0)O-X3, -C(0)NH-X4, -C(O)N(alkyl) 2 , -C(O)N(cycloalkyl) 2 , -C(O)N(aryl) 2 , -C(0)N(heteroaryl)2, -S(O)-alkyl, S(0)-aryl, -S(0 2 )-alkyl, -S(0 2 )-aryl, -S(0 2 )NH-alkyl, -S(0 2 )NH-aryl, S(0 2 )NH-heteroaryl, -S(0 2 )NH-arylalkyl, S(0 2 )0-alkyl, -S(0 2 )O-aryl, 10 S(0 2 )0-arylalkyl"; where X1, X2, X3, X4 are each independently selected from the group consisting of: "alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; with the proviso that the above substituents of substituent group (a) are 15 each independently substituted further by at least one substituent selected identically or differently from the group consisting of: (i) "(C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl,

N

3 , -NH cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, 20 -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NX5X6, S-cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -0 cycloalkyl, -0-cycloalkylalkyl, -0-arylalkyl, -0-heteroaryl, -0 heteroarylalkyl, -0-heterocyclyl, -0-heterocyclylalkyl,-O(-X7-0)p 25 X8 (p = 1, 2, 3, 4, 5), -OP(O)(OX9)(OX1 0), -C(O)O-X1 1, -C(O)NH 2 , -C(O)NH-X12, -C(O)NX13X14, -S(0 2 )-X15, -P(O)(OH) 2 , P(O)(OX16)(OX17), -Si(X18)(X19)(X20), -0-Si(X21)(X22)(X23), -0 C(0)-O-X24, -0-C(O)-NH-X25, -0-C(O)-NX26X27,

-NH-C(O)

O-X28, -NH-C(O)-NH-X29, -NH-C(O)-NX3OX31, -NX32-C(O)-0 30 X33, -NX34-C(O)-NH-X35, -NX36-C(O)-NX37X38, -O-S(0 2 )-X39, -NH-C(O)-X40, -NX41-C(O)-X42, -C(O)-X43, -OC(0)-X44, S(0)-X45, -S(0 2 )-NHX46, -S(0 2 )-NX47X48, -S(0 2 )-OX49, -0( X50-0)p-H (p = 1, 2, 3, 4, 5)"; W02007/054556 PCT/EP2006/068322 -10 with the further proviso that "-N(alkyl)2" is further substituted by at least one substituent selected from the following substituent group (b); where X5, X6, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, X18, X19, X20, X21, X22, X23, X24, X25, X26, X27, X28, X29, X30, 5 X31, X32, X33, X34, X35, X36, X37, X38, X39, X40, X41, X42, X43, X44, X45, X46, X47, X48, X49, X50 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X13, X14 and/or 10 X26, X27 and/or X30, X31 and/or X37, X38 and/or X47, X48 together may also form "heterocyclyl"; and with the further proviso that when one of the Z3 or Z4 radicals is "substituted aryl" substituted by "heterocyclylalkyl", the other Z3 or Z4 radical in each case is not "substituted or unsubstituted aryl"; 15 where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (b) "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, 20 CF 3 , N 3 , NH 2 , -NHX51, -NX52X53, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X54, -C(O)O-X55, -C(O)NH-X56, -C(O)NX57X58, -O-X59, -O(-X60-0),-H (r = 1, 2, 3, 4, 5), -O(-X61-O),-X62 (r = 1, 2, 3, 4, 5), -OC(O)-X63, -OC(0) O-X64, -OC(O)-NHX65, -O-C(O)-NX66X67, -OP(O)(OX68)(OX69), 25 OSi(X70)(X71)(X72), -OS(0 2 )-X73, -NHC(O)-X74, -NX75C(O)-X76, NH-C(O)-0-X77, -NH-C(O)-NH-X78, -NH-C(O)-NX79X80, -NX81 C(O)-0-X82, -NX83-C(O)-NH-X84, -NX85-C(O)-NX86X87, -NHS(0 2

)

X88, -NX89S(0 2 )-X90, -S-X91, -S(O)-X92, -S(0 2 )-X93, -S(0 2 )NH-X94, -S(0 2 )NX95X96, -S(0 2 )O-X97, -P(O)(OX98)(OX99), 30 Si(X1 00)(X1 01)(X1 02)"; where X51, X52, X53, X54, X55, X56, X57, X58, X59, X60, X61, X62, X63, X64, X65, X66, X67, X68, X69, X70, X71, X72, X73, X74, X75, X76, X77, X78, X79, X80, X81, X82, X83, X84, X85, X86, X87, X88, X89, X90, X91, W02007/054556 PCT/EP2006/068322 X92, X93, X94, X95, X96, X97, X98, X99, X100, X101, X102 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X57, X58 and/or X66, 5 X67 and/or X79, X80 and/or X86, X87 and/or X95, X96 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (b) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (ii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX103, -NX104X105,

-NO

2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X106, -C(O)O-X107, -C(O)NH-X108, 15 C(O)NX109X110, -O-X111, -O(-X112-0),-H (s = 1, 2, 3, 4, 5), -O( X1 13-0),-X1 14 (s = 1, 2, 3, 4, 5), -OC(O)-X1 15, -OC(O)-O-X1 16, OC(O)-NHX1 17, -O-C(O)-NX1 18X1 19, -OP(O)(OX1 20)(OX121), OSi(X122)(X123)(X124),

-OS(O

2 )-X125, -NHC(O)-X126, NX1 27C(O)-X1 28, -NH-C(O)-O-X1 29, -NH-C(O)-NH-X1 30, -NH 20 C(O)-NX1 31 X1 32, -NX1 33-C(O)-O-X1 34, -NX1 35-C(O)-NH-X1 36, -NX1 37-C(O)-NX1 38X1 39, -NHS(0 2 )-X1 40, -NX1 41 S(0 2 )-X1 42, -S X1 43, -S(O)-X1 44, -S(0 2 )-X1 45, -S(0 2 )NH-X146, -S(0 2 )NX1 47X1 48, -S(0 2 )O-X1 49, -P(O)(OX1 50)(OX1 51), -Si(X1 52)(X1 53)(X1 54)"; where X103, X104, X105, X106, X107, X108, X109, X110, X111, X112, 25 X11 3 , X11 4 , X115, X116, X117, X118, X119, X120, X121, X122, X123, X124, X125, X126, X127, X128, X129, X130, X131, X132, X133, X134, X135, X136, X137, X138, X139, X140, X141, X142, X143, X144, X145, X146, X147, X148, X149, X150, X151, X152, X153, X154 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, 30 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1 09, X110 and/or X118, X119 and/or X131, X132 and/or X138, X139 and/or X147, X148 together may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 12 where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX155, -NX156X157,

-NO

2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X158, -C(O)O-X159, -C(O)NH-X160, 10 C(O)NX161X162, -O-X163, -O(-X164-O)-H (t = 1, 2, 3, 4, 5), -O( X1 65-O)t-X1 66 (t = 1, 2, 3, 4, 5), -OC(O)-X1 67, -OC(O)-O-X1 68, OC(O)-NHX1 69, -O-C(O)-NX1 70X1 71, -OP(O)(OX1 72)(OX1 73), OSi(X1 74)(X1 75)(X1 76), -OS(0 2 )-X1 77, -NHC(O)-X1 78, NX1 79C(O)-X1 80, -NH-C(O)-O-X181, -NH-C(O)-NH-X1 82, -NH 15 C(O)-NX183X184, -NX185-C(O)-O-X186, -NX187-C(O)-NH-X188, -NX1 89-C(O)-NX1 90X1 91, -NHS(0 2 )-X1 92, -NX1 93S(0 2 )-X1 94, -S X1 95, -S(O)-X1 96, -S(0 2 )-X1 97, -S(0 2 )NH-X1 98, -S(0 2 )NX1 99X200, -S(0 2 )O-X201, -P(O)(OX202)(OX203), -Si(X204)(X205)(X206)"; where X155, X156, X157, X158, X159, X160, X161, X162, X163, X164, 20 X165, X166, X167, X168, X169, X170, X171, X172, X173, X174, X175, X176, X177, X178, X179, X180, X181, X182, X183, X184, X185, X186, X187, X188, X189, X190, X191, X192, X193, X194, X195, X196, X197, X198, X199, X200, X201, X202, X203, X204, X205, X206 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, 25 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1 61, X1 62 and/or X170, X171 and/or X183, X184 and/or X190, X191 and/or X199, X200 together may also form "heterocyclyl"; 30 or one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted aryl", where "substituted aryl" is substituted by at least one substituent selected identically or differently from the group consisting of: W020071054556 PCT/EP20061068322 -13 (c) "(C 9

-C

30 )alkyl, -NX207X208, -NH-(Cg-C 30 )alkyl, -NHC(O)-cycloalkylalkyl, NHC(O)-heterocyclylalkyl, -NHC(O)-(Cg-C 30 )alkyl, -NX209C(O)-X210, NX21 1 C(O)-(C9-C 3 0)alkyl, -NHC(O)-OX212, -NX213C(O)-OX214, NHC(O)-NHX215, -NHC(O)-NX216X217, -NX218C(O)-NHX219, 5 NX220C(O)-NX221X222, -NHS(0 2 )-cycloalkylalkyl, -NHS(0 2

)

heterocyclylalkyl, -NX223S(0 2 )-X224, -O-(C-C 30 )alkyl, -S-cycloalkyl, -S heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl, -S-cycloalkylalkyl, -S heterocyclylalkyl, -S-(C 9

-C

30 )alkyl, -OC(O)-cycloalkylalkyl,

-OC(O)

heterocyclylalkyl, -OC(O)-(Cg-C 30 )alkyl, -OS(0 2 )-cycloalkylalkyl, -OS(02) 10 heterocyclylalkyl, -OS(0 2 )-(Cg-C 30 )alkyl, -OC(O)-OX225, -OC(O) NHX226, -OC(O)-NX227X228, -OP(O)(OX229)(OX230), -C(O)-cycloalkyl, -C(O)-heterocyclyl, -C(O)-arylalkyl, -C(0)-heteroarylalkyl,

-C(O)

cycloalkylalkyl, -C(O)-heterocyclylalkyl,

-C(O)-(C-C

30 )alkyl, -C(0)0-(C

C

30 )alkyl, -C(O)NH-(C-C 3 0 )alkyl, -C(O)NX231X232, -C(O)NH-OX233, 15 C(O)NX234-OX235, -C(O)NH-NX236X237, -C(O)NX238-NX239X240, S(O)-cycloalkyl, -S(O)-heterocyclyl, -S(O)-heteroaryl, -S(O)-arylalkyl, S(O)-heteroarylalkyl, -S(O)-cycloalkylalkyl, -S(O)-heterocyclylalkyl, S(O)-(C-C 30 )alkyl, -S(0 2 )-cycloalkyl, -S(0 2 )-heterocycly, -S(02) heteroaryl, -S(0 2 )-arylalkyl, -S(0 2 )-heteroarylalkyl, -S(0 2 )-cycloalkylalkyl, 20 -S(0 2 )-heterocyclylalkyl, -S(0 2

)-(C

9

-C

30 )alkyl, -S(0 2 )NH-cycloalkyl, S(0 2 )NH-heterocyclyl, -S(0 2 )NH-heteroarylalkyl, -S(0 2

)NH

cycloalkylalkyl, -S(0 2 )NH-heterocyclylalkyl, -S(0 2

)NH-(C

9

-C

30 )alkyl, S(0 2 )O-cycloalkyl, -S(0 2 )0-heterocyclyl, -S(0 2 )0-heteroaryl, -S(0 2 )0 heteroarylalkyl, -S(0 2 )O-cycloalkylalkyl, -S(0 2 )O-heterocyclylalkyl, 25 S(0 2 )0-(C-C 30 )alkyl, -P(O)(OH) 2 , -P(O)(OX241)(OX242), Si(X243)(X244)(X245), -O-Si(X246)(X247)(X248)"; where X207, X208, X209, X210, X211, X212, X213, X214, X215, X216, X217, X218, X219, X220, X221, X222, X223, X224, X225, X226, X227, X228, X229, X230, X231, X232, X233, X234, X235, X236, X237, X238, 30 X239, X240, X241, X242, X243, X244, X245, X246, X247, X248 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X216, X217 and/or W02007/054556 PCT/EP2006/068322 X221, X222 and/or X227, X228 and/or X231, X232 and/or X236, X237 and/or X239, X240, in each case together, may also form "heterocyclyl"; with the proviso that the substituents "-N(alkyl) 2 ", "-C(O)N(alkyl) 2 ", " C(O)N(cycloalkyl) 2 ", "-C(O)N(aryl) 2 ", "-C(O)N(heteroaryl) 2 " are substituted 5 further by at least one substituent selected from the following substituent group (i); with the further proviso that when one of the Z3 or Z4 radicals is "substituted aryl" substituted by "heterocyclylalkyl", the other Z3 or Z4 radical in each case is not "unsubstituted or substituted aryl"; 10 where, optionally, the above substituents of substituent group (c) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, 15 CN, CF 3 , N 3 , NH 2 , -NHX249, -NX250X251, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X252, -C(O)O-X253, -C(O)NH-X254, C(O)NX255X256, -O-X257, -O(-X258-0),-H (u = 1, 2, 3, 4, 5), -O( X259-0),-X260 (u = 1, 2, 3, 4, 5), -OC(O)-X261, -OC(O)-O-X262, 20 OC(O)-NHX263, -O-C(O)-NX264X265, -OP(O)(OX266)(OX267), OSi(X268)(X269)(X270), -OS(0 2 )-X271, -NHC(O)-X272, NX273C(O)-X274, -NH-C(O)-O-X275, -NH-C(O)-NH-X276,

-NH

C(O)-NX277X278, -NX279-C(O)-O-X280, -NX281-C(O)-NH-X282, -NX283-C(O)-NX284X285, -NHS(0 2 )-X286, -NX287S(0 2 )-X288, -S 25 X289, -S(O)-X290, -S(0 2 )-X291, -S(0 2 )NH-X292, -S(0 2 )NX293X294, -S(0 2 )O-X295, -P(O)(OX296)(OX297), -Si(X298)(X299)(X300)"; where X249, X250, X251, X252, X253, X254, X255, X256, X257, X258, X259, X260, X261, X262, X263, X264, X265, X266, X267, X268, X269, X270, X271, X272, X273, X274, X275, X276, X277, X278, X279, X280, 30 X281, X282, X283, X284, X285, X286, X287, X288, X289, X290, X291, X292, X293, X294, X295, X296, X297, X298, X299, X300 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, W02007/054556 PCT/EP2006/068322 - 15 heteroaryl, heteroarylalkyl" and where, alternatively, X255, X256 and/or X264, X265 and/or X277, X278 and/or X284, X285 and/or X293, X294, in each case together, may also form "heterocyclyl"; where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, 5 Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (d) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN,

CF

3 , N 3 , NH 2 , -NHX301, -NX302X303, -NO 2 , -OH, -OCF 3 , -SH, -0 10 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-X304, -C(O)O-X305, -C(O)NH-X306, -C(O)NX307X308, -O-X309, -O(-X31 0-O)uu-H (uu = 1, 2, 3, 4, 5), -O(-X31 1 -O).u-X312 (uu = 1, 2, 3, 4, 5), -OC(O)-X313, -OC(O)-O-X314, -OC(O)-NHX315, -0-C(O) NX316X317, -OP(O)(OX318)(OX319), -OSi(X320)(X321)(X322),

-OS(O

2

)

15 X323, -NHC(O)-X324, -NX325C(O)-X326, -NH-C(O)-O-X327,

-NH

C(O)-NH-X328, -NH-C(O)-NX329X330, -NX331-C(O)-O-X332, NX333-C(O)-NH-X334, -NX335-C(O)-NX336X337, -NHS(0 2 )-X338, NX339S(0 2 )-X340, -S-X341, -S(O)-X342, -S(0 2 )-X343, -S(0 2

)NH

X344, -S(0 2 )NX345X346, -S(0 2 )O-X347, -P(O)(OX348)(OX349), 20 Si(X350)(X351)(X352)"; where X301, X302, X303, X304, X305, X306, X307, X308, X309, X310, X311, X312, X313, X314, X315, X316, X317, X318, X319, X320, X321, X322, X323, X324, X325, X326, X327, X328, X329, X330, X331, X332, X333, X334, X335, X336, X337, X338, X339, X340, X341, X342, X343, 25 X344, X345, X346, X347, X348, X349, X350, X351, X352 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X307, X308 and/or X316, X317 and/or X329, X330 and/or X336, X337 and/or X345, X346, in 30 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (d) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 -16- PCT/EP2006/068322 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX353, -NX354X355,

-NO

2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 5

P(O)(OH)

2 , -C(O)-X356, -C(O)O-X357, -C(O)NH-X358, C(O)NX359X360, -O-X361, -O(-X362-0),-H (v = 1, 2, 3, 4, 5), -O( X363-0),-X364 (v = 1, 2, 3, 4, 5), -OC(O)-X365, -OC(O)-O-X366, OC(O)-NHX367, -O-C(O)-NX368X369, -OP(O)(OX370)(OX371), OSi(X372)(X373)(X374), -OS(0 2 )-X375, -NHC(O)-X376, 10 NX377C(O)-X378, -NH-C(O)-O-X379, -NH-C(O)-NH-X380,

-NH

C(O)-NX381X382, -NX383-C(O)-O-X38 4 , -NX385-C(O)-NH-X386, -NX387-C(O)-NX388X389, -NHS(0 2 )-X390, -NX391S(0 2 )-X392, -S X393, -S(O)-X394, -S(0 2 )-X395, -S(0 2 )NH-X396, -S(0 2 )NX397X398, -S(0 2 )O-X399, -P(O)(OX400)(OX401), -Si(X402)(X403)(X404)"; 15 where X353, X354, X355, X356, X357, X358, X359, X360, X361, X362, X363, X364, X365, X366, X367, X368, X369, X370, X371, X372, X373, X374, X375, X376, X377, X378, X379, X380, X381, X382, X383, X384, X385, X386, X387, X388, X389, X390, X391, X392, X393, X394, X395, X396, X397, X398, X399, X400, X401, X402, X403, X404 are each 20 independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X359, X360 and/or X368, X369 and/or X381, X382 and/or X388, X389 and/or X397, X398, in each case together, may also form "heterocyclyl"; 25 where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX405, -NX406X407,

-NO

2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH)2, -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X408, -C(O)O-X409, -C(O)NH-X410, C(O)NX411X412, -O-X413, -O(-X414-O)w-H (w = 1, 2, 3, 4, 5), -O(- W02007/054556 PCT/EP2006/068322 X415-O)w-X416 (w = 1, 2, 3, 4, 5), -OC(O)-X417, -OC(O)-O-X418, OC(O)-NHX419, -O-C(O)-NX420X421, -OP(O)(OX422)(OX423), OSi(X424)(X425)(X426), -OS(0 2 )-X427, -NHC(O)-X428, NX429C(O)-X430, -NH-C(O)-O-X431, -NH-C(O)-NH-X432,

-NH

5 C(O)-NX433X434, -NX435-C(O)-O-X436, -NX437-C(O)-NH-X438, -NX439-C(O)-NX440X441, -NHS(0 2 )-X442, -NX443S(O 2 )-X444, -S X445, -S(O)-X446, -S(0 2 )-X447, -S(0 2 )NH-X448, -S(0 2 )NX449X450, -S(0 2 )O-X451, -P(O)(OX452)(OX453), -Si(X454)(X455)(X456)"; where X405, X406, X407, X408, X409, X410, X411, X412, X413, X414, 10 X415, X416, X417, X418, X419, X420, X421, X422, X423, X424, X425, X426, X427, X428, X429, X430, X431, X432, X433, X434, X435, X436, X437, X438, X439, X440, X441, X442, X443, X444, X445, X446, X447, X448, X449, X450, X451, X452, X453, X454, X455, X456 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 o)alkyl, 15 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X41 1, X412 and/or X420, X421 and/or X433, X434 and/or X440, X441 and/or X449, X450, in each case together, may also form "heterocyclyl"; 20 and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently selected from the group consisting of: (e) hydrogen; (f) halogen, F, Cl, Br, 1; (g) unsubstituted or substituted alkyl or (C 9

-C

30 )alkyl, where, optionally, the 25 alkyl or (Cg-C 30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHX457, -NX458X459, -NO 2 , -OH, -OCF 3 , -SH, 30

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X460, -C(O)O-X461, -C(O)NH-X462, C(O)NX463X464, -O-X465, -O(-X466-O).-H (x = 1, 2, 3, 4, 5), -O( X467-0),-X468 (x = 1, 2, 3, 4, 5), -OC(O)-X469, -OC(O)-O-X470,

-

W02007/054556 PCT/EP2006/068322 -18 OC(O)-NHX471, -O-C(O)-NX472X473, -OP(O)(OX474)(OX475), OSi(X476)(X477)(X478), -OS(02)-X479, -NHC(O)-X480, NX481C(O)-X482, -NH-C(O)-O-X483, -NH-C(O)-NH-X484,

-NH

C(O)-NX485X486, -NX487-C(O)-O-X488, -NX489-C(O)-NH 5 X490, -NX491-C(O)-NX492X493, -NHS(0 2 )-X494, -NX495S(0 2

)

X496, -S-X497, -S(O)-X498, -S(0 2 )-X499, -S(0 2 )NH-X500, S(0 2 )NX501 X502, -S(0 2 )O-X503, -P(O)(OX504)(OX505), Si(X506)(X507)(X508)"; where X457, X458, X459, X460, X461, X462, X463, X464, X465, 10 X466, X467, X468, X469, X470, X471, X472, X473, X474, X475, X476, X477, X478, X479, X480, X481, X482, X483, X484, X485, X486, X487, X488, X489, X490, X491, X492, X493, X494, X495, X496, X497, X498, X499, X500, X501, X502, X503, X504, X505, X506, X507, X508 are each independently selected from the group 15 consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X463, X464 and/or X472, X473 and/or X485, X486 and/or X492, X493 and/or X501, X502, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 25 Br, I, CN, CF 3 , N 3 , NH 2 , -NHX509, -NX51OX511, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-X512, -C(O)O-X513,

-C(O)NH

X514, -C(O)NX515X516, -O-X517, -O(-X518-O)y-H (y = 1, 2, 3, 4, 5), -O(-X519-O)y-X520 (y = 1, 2, 3, 4, 5), -OC(O)-X521, 30 OC(O)-O-X522, -OC(O)-NHX523, -O-C(O)-NX524X525, OP(O)(OX526)(OX527), -OSi(X528)(X529)(X530), -OS(0 2

)

X531, -NHC(O)-X532, -NX533C(O)-X534, -NH-C(O)-O-X535, -NH-C(O)-NH-X536, -NH-C(O)-NX537X538, -NX539-C(O)-O X540, -NX541-C(O)-NH-X542, -NX543-C(O)-NX544X545,

-

W02007/054556 PCT/EP2006/068322 NHS(0 2 )-X546, -NX547S(0 2 )-X548, -S-X549, -S(O)-X550, S(0 2 )-X551, -S(0 2 )NH-X552, -S(0 2 )NX553X554, -S(0 2

)O

X555, -P(O)(OX556)(OX557), -Si(X558)(X559)(X560)"; where X509, X510, X511, X512, X513, X514, X515, X516, X517, 5 X518, X519, X520, X521, X522, X523, X524, X525, X526, X527, X528, X529, X530, X531, X532, X533, X534, X535, X536, X537, X538, X539, X540, X541, X542, X543, X544, X545, X546, X547, X548, X549, X550, X551, X552, X553, X554, X555, X556, X557, X558, X559, X560 are each independently selected from the group 10 consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X515, X516 and/or X524, X525 and/or X537, X538 and/or X544, X545 and/or X553, X554, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHX561, -NX562X563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X564, -C(O)O-X565, C(O)NH-X566, -C(O)NX567X568, -O-X569, -O(-X570-0) 25 H (z = 1, 2, 3, 4, 5), -O(-X571-O),-X572 (z = 1, 2, 3, 4, 5), OC(O)-X573, -OC(O)-O-X574, -OC(O)-NHX575, -0-C(0) NX576X577, -OP(O)(OX578)(OX579), OSi(X580)(X581)(X582), -OS(0 2 )-X583, -NHC(O)-X584, NX585C(O)-X586, -NH-C(O)-O-X587,

-NH-C(O)-NH

30 X588, -NH-C(O)-NX589X590, -NX591-C(O)-O-X592, NX593-C(O)-NH-X594, -NX595-C(O)-NX596X597, NHS(0 2 )-X598, -NX599S(0 2 )-X600, -S-X601, -S(O)-X602, -S(0 2 )-X603, -S(0 2 )NH-X604, -S(0 2 )NX605X606, -S(0 2

)O

X607, -P(O)(OX608)(OX609), -Si(X61 0)(X61 1)(X612)"; W02007/054556 -20- PCT/EP20061068322 where X561, X562, X563, X564, X565, X566, X567, X568, X569, X570, X571, X572, X573, X574, X575, X576, X577, X578, X579, X580, X581, X582, X583, X584, X585, X586, X587, X588, X589, X590, X591, X592, X593, X594, X595, 5 X596, X597, X598, X599, X600, X601, X602, X603, X604, X605, X606, X607, X608, X609, X610, X611, X612 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 10 where, alternatively, X567, X568 and/or X576, X577 and/or X589, X590 and/or X596, X597 and/or X605, X606, in each case together, may also form "heterocyclyl"; (h) unsubstituted or substituted aryl where, optionally, the aryl radical may be 15 substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX613, -NX614X615,

-NO

2 , -OH, -OCF 3 , -SH, 20

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X616, -C(O)O-X617, -C(O)NH-X618, C(O)NX619X620, -O-X621, -0(-X622-0)a-H (a = 1, 2, 3, 4, 5), -O( X623-0)a-X624 (a = 1, 2, 3, 4, 5), -OC(O)-X625, -OC(O)-O-X626, OC(O)-NHX627, -O-C(O)-NX628X629, -OP(O)(OX630)(OX631), 25 OSi(X632)(X633)(X634), -OS(0 2 )-X635, -NHC(O)-X636, NX637C(O)-X638, -NH-C(O)-O-X639, -NH-C(O)-NH-X640,

-NH

C(O)-NX641X642, -NX643-C(O)-O-X644, -NX645-C(O)-NH X646, -NX647-C(O)-NX648X649, -NHS(0 2 )-X650, -NX651S(0 2

)

X652, -S-X653, -S(O)-X654, -S(0 2 )-X655, -S(0 2 )NH-X656, 30 S(0 2 )NX657X658, -S(0 2 )O-X659, -P(O)(OX660)(OX661), Si(X662)(X663)(X664)"; where X613, X614, X615, X616, X617, X618, X619, X620, X621, X622, X623, X624, X625, X626, X627, X628, X629, X630, X631, W02007/054556 PCT/EP2006/068322 - 21 X632, X633, X634, X635, X636, X637, X638, X639, X640, X641, X642, X643, X644, X645, X646, X647, X648, X649, X650, X651, X652, X653, X654, X655, X656, X657, X658, X659, X660, X661, X662, X663, X664 are each independently selected from the group 5 consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X61 9, X620 and/or X628, X629 and/or X641, X642 and/or X648, X649 and/or X657, X658, in each case together, may also form "heterocycly"; 10 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 15 Br, I, CN, CF 3 , N 3 , NH 2 , -NHX665, -NX666X667, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-X668, -C(O)O-X669,

-C(O)NH

X670, -C(O)NX671X672, -0-X673, -O(-X674-O)b-H (b = 1, 2, 3, 4, 5), -O(-X675-0)b-X6 76 (b = 1, 2, 3, 4, 5), -OC(O)-X677, 20 OC(O)-O-X678, -OC(O)-NHX679, -0-C(O)-NX680X681, OP(O)(OX682)(OX683), -OSi(X684)(X685)(X686), -OS(0 2

)

X687, -NHC(O)-X688, -NX689C(O)-X690, -NH-C(O)-O-X691, -NH-C(O)-NH-X692, -NH-C(O)-NX693X694, -NX695-C(O)-O X696, -NX697-C(O)-NH-X698, -NX699-C(O)-NX700X701, 25 NHS(0 2 )-X702, -NX703S(0 2 )-X704, -S-X705, -S(O)-X706, S(0 2 )-X707, -S(0 2 )NH-X708, -S(0 2 )NX709X710, -S(0 2

)O

X71 1, -P(O)(OX712)(OX713), -Si(X714)(X715)(X716)"; where X665, X666, X667, X668, X669, X670, X671, X672, X673, X674, X675, X676, X677, X678, X679, X680, X681, X682, X683, 30 X684, X685, X686, X687, X688, X689, X690, X691, X692, X693, X694, X695, X696, X697, X698, X699, X700, X701, X702, X703, X704, X705, X706, X707, X708, X709, X710, X711, X712, X713, X714, X715, X716 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, W02007/054556 PCT/EP2006/068322 - 22 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X671, X672 and/or X680, X681 and/or X693, X694 and/or X700, X701 and/or X709, X710, in each case together, may also form "heterocyclyl"; 5 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX717, -NX718X719, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X720, -C(O)O-X721, C(O)NH-X722, -C(O)NX723X724, -O-X725, -O(-X726-O)c 15 H (c = 1, 2, 3, 4, 5), -O(-X727-0)c-X728 (c = 1, 2, 3, 4, 5), OC(O)-X729, -OC(O)-O-X730, -OC(O)-NHX731, -0-C(O) NX732X733, -OP(O)(OX734)(OX735), OSi(X736)(X737)(X738), -OS(0 2 )-X739, -NHC(O)-X740, NX741 C(O)-X742, -N H-C(O)-O-X743, -N H-C(O)-N H 20 X744, -NH-C(O)-NX745X746, -NX747-C(O)-O-X748, NX749-C(O)-NH-X750, -NX751-C(O)-NX752X753, NHS(0 2 )-X754, -NX755S(0 2 )-X756, -S-X757, -S(O)-X758, -S(0 2 )-X759, -S(0 2 )NH-X760, -S(0 2 )NX761X762, -S(0 2

)O

X763, -P(O)(OX764)(OX765), -Si(X766)(X767)(X768)"; 25 where X717, X718, X719, X720, X721, X722, X723, X724, X725, X726, X727, X728, X729, X730, X731, X732, X733, X734, X735, X736, X737, X738, X739, X740, X741, X742, X743, X744, X745, X746, X747, X748, X749, X750, X751, X752, X753, X754, X755, X756, X757, X758, X759, X760, 30 X761, X762, X763, X764, X765, X766, X767, X768 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X723, X724 and/or X732, X733 and/or W02007/054556 PCT/EP2006/068322 - 23 X745, X746 and/or X752, X753 and/or X761, X762, in each case together, may also form "heterocyclyl"; (j) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl 5 radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX769, -NX770X771,

-NO

2 , -OH, -OCF 3 , -SH, 10

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X772, -C(O)O-X773, -C(O)NH-X774, C(O)NX775X776, -O-X777, -O(-X778-O)d-H (d = 1, 2, 3, 4, 5), -O( X779-O)d-X780 (d = 1, 2, 3, 4, 5), -OC(O)-X781, -OC(O)-O-X782, OC(O)-NHX783, -O-C(O)-NX784X785, -OP(O)(OX786)(OX787), 15 OSi(X788)(X789)(X790), -OS(0 2 )-X791, -NHC(O)-X792, NX793C(O)-X794, -NH-C(O)-O-X795, -NH-C(O)-NH-X796,

-NH

C(O)-NX797X798, -NX799-C(O)-O-X800, -NX801-C(O)-NH X802, -NX803-C(O)-NX804X805, -NHS(0 2 )-X806, -NX807S(0 2

)

X808, -S-X809, -S(O)-X810, -S(0 2 )-X811, -S(0 2 )NH-X812, 20 S(0 2 )NX813X814, -S(0 2 )O-X815, -P(O)(OX816)(OX817), Si(X81 8)(X819)(X820)"; where X769, X770, X771, X772, X773, X774, X775, X776, X777, X778, X779, X780, X781, X782, X783, X784, X785, X786, X787, X788, X789, X790, X791, X792, X793, X794, X795, X796, X797, 25 X798, X799, X800, X801, X802, X803, X804, X805, X806, X807, X808, X809, X810, X811, X812, X813, X814, X815, X816, X817, X818, X819, X820 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 30 heteroarylalkyl" and where, alternatively, X775, X776 and/or X784, X785 and/or X797, X798 and/or X804, X805 and/or X813, X814, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -24 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX821, -NX822X823,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH)2, -C(O)-X824, -C(O)O-X825,

-C(O)NH

X826, -C(O)NX827X828, -O-X829, -O(-X830-0)e-H (e = 1, 2, 3, 10 4, 5), -0(-X831-0)e-X832 (e = 1, 2, 3, 4, 5), -OC(O)-X833, OC(O)-O-X834, -OC(O)-NHX835, -O-C(O)-NX836X837, OP(O)(OX838)(OX839), -OSi(X840)(X841)(X842), -OS(0 2

)

X843, -NHC(O)-X844, -NX845C(O)-X846, -NH-C(O)-O-X847, -NH-C(O)-NH-X848, -NH-C(O)-NX849X850, -NX851-C(O)-O 15 X852, -NX853-C(O)-NH-X854, -NX855-C(O)-NX856X857, NHS(0 2 )-X858, -NX859S(0 2 )-X860, -S-X861, -S(O)-X862, S(0 2 )-X863, -S(0 2 )NH-X864, -S(0 2 )NX865X866, -S(0 2

)O

X867, -P(O)(OX868)(OX869), -Si(X870)(X871)(X872)'; where X821, X822, X823, X824, X825, X826, X827, X828, X829, 20 X830, X831, X832, X833, X834, X835, X836, X837, X838, X839, X840, X841, X842, X843, X844, X845, X846, X847, X848, X849, X850, X851, X852, X853, X854, X855, X856, X857, X858, X859, X860, X861, X862, X863, X864, X865, X866, X867, X868, X869, X870, X871, X872 are each independently selected from the group 25 consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X827, X828 and/or X836, X837 and/or X849, X850 and/or X856, X857 and/or X865, X866, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 -25- PCT/EP2006/068322 (iii) alkyll, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX873, -NX874X875,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 5

C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X876, -C(O)O-X877, C(O)NH-X878, -C(O)NX879X880, -O-X881,

-O(-X

882 -O)r H (f = 1, 2, 3, 4, 5), -O(-X883-O)f-X884 (f = 1, 2, 3, 4, 5), OC(O)-X885, -OC(O)-O-X886, -OC(O)-NHX887, -0-C(O) NX888X889, -OP(O)(OX890)(OX891), 10 OSi(X892)(X893)(X894), -OS(0 2 )-X895, -NHC(O)-X896, NX897C(O)-X898, -NH-C(O)-0-X899,

-NH-C(O)-NH

X900, -NH-C(O)-NX901X902, -NX903-C(O)-0-X90 4 , NX905-C(O)-NH-X906, -NX907-C(O)-NX908X909, NHS(0 2 )-X91 0, -NX91 1 S(0 2 )-X912, -S-X913, -S(O)-X914, 15 -S(0 2 )-X915, -S(0 2 )NH-X916, -S(0 2 )NX917X918, -S(0 2

)O

X919, -P(O)(OX920)(OX921), -Si(X922)(X923)(X924)"; where X873, X874, X875, X876, X877, X878, X879, X880, X881, X882, X883, X884, X885, X886, X887, X888, X889, X890, X891, X892, X893, X894, X895, X896, X897, X898, 20 X899, X900, X901, X902, X903, X904, X905, X906, X907, X908, X909, X910, X911, X912, X913, X914, X915, X916, X917, X918, X919, X920, X921, X922, X923, X924 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X879, X880 and/or X888, X889 and/or X901, X902 and/or X908, X909 and/or X917, X918, in each case together, may also form "heterocyclyl"; 30 (k) OZ6 where Z6 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; W02007/054556 PCT/EP2006/068322 - 26 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX925, -NX926X927,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-X928, -C(O)O-X929,

-C(O)NH

X930, -C(O)NX931X932, -O-X933, -O(-X934-O)g-H (g = 1, 2, 3, 10 4, 5), -O(-X935-0)g-X 93 6 (g = 1, 2, 3, 4, 5), -OC(O)-X937, OC(O)-O-X938, -OC(O)-NHX939, -O-C(O)-NX940X941, OP(O)(OX942)(OX943), -OSi(X944)(X945)(X946), -OS(0 2

)

X947, -NHC(O)-X948, -NX949C(O)-X950, -NH-C(O)-O-X951, -N H-C(O)-NH-X952, -NH-C(O)-NX953X954, -NX955-C(O)-O 15 X956, -NX957-C(O)-NH-X958, -NX959-C(O)-NX960X961, NHS(0 2 )-X962, -NX963S(0 2 )-X964, -S-X965, -S(O)-X966, S(0 2 )-X967, -S(0 2 )NH-X968, -S(0 2 )NX969X970, -S(0 2

)O

X971, -P(O)(OX972)(OX973), -Si(X974)(X975)(X976)"; where X925, X926, X927, X928, X929, X930, X931, X932, X933, 20 X934, X935, X936, X937, X938, X939, X940, X941, X942, X943, X944, X945, X946, X947, X948, X949, X950, X951, X952, X953, X954, X955, X956, X957, X958, X959, X960, X961, X962, X963, X964, X965, X966, X967, X968, X969, X970, X971, X972, X973, X974, X975, X976 are each independently selected from the group 25 consisting of: "alkyl, (COg-C 3 o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X931, X932 and/or X940, X941 and/or X953, X954 and/or X960, X961 and/or X969, X970, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 - 27 (iii) "alkyl, (C 9 -C3o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX977, -NX978X979,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 5

C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X980, -C(O)O-X981, C(O)NH-X982, -C(O)NX983X984, -O-X985, -O(-X986-O)h H (h = 1, 2, 3, 4, 5), -O(-X987-O)h-X 988 (h = 1, 2, 3, 4, 5), OC(O)-X989, -OC(O)-O-X990, -OC(O)-NHX991, -0-C(O) NX992X993, -OP(O)(OX994)(OX995), 10 OSi(X996)(X997)(X998), -OS(0 2 )-X999, -NHC(O)-X1 000, NX1001C(O)-X1002, -NH-C(O)-O-X1003,

-NH-C(O)-NH

X1004, -NH-C(O)-NX1005X1006, -NX1007-C(O)-O-X1008, -NX1009-C(O)-NH-X1010, -NX1011-C(O)-NX1012X1013, NHS(0 2 )-X1014, -NX1015S(0 2 )-X1016, -S-X1017, -S(O) 15 X1018, -S(0 2 )-X1019, -S(0 2 )NH-X1020, S(0 2 )NX1021X1022, -S(0 2 )O-X1023, P(O)(OX1 024)(OX1 025), -Si(X1 026)(X1 027)(X1 028)"; where X977, X978, X979, X980, X981, X982, X983, X984, X985, X986, X987, X988, X989, X990, X991, X992, X993, 20 X994, X995, X996, X997, X998, X999, Xl000, X1001, X1002, X1003, X1004, X1005, X1006, X1007, X1008, X1009, X101O, X1011, X1012, X1013, X1014, X1015, X1016, X1017, X1018, X1019, X1020, X1021, X1022, X1023, X1024, X1025, X1026, X1 027, X1028 are each independently selected from the group 25 consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X983, X984 and/or X992, X993 and/or X1 005, X1006 and/or X1012, X1013 and/or X1 021, X1 022, in each case together, may also form 30 "heterocyclyl"; (1) SZ7 where Z7 is independently selected from the group consisting of: W020071054556 -28- PCT/EP20061068322 (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 5 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX1029, -NX1030X1031,

-NO

2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 10

C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1032, -C(O)O-X1033, C(O)NH-X1034, -C(O)NX1035X1036, -O-X1037, -O(-X1038 O)rH (i = 1, 2, 3, 4, 5), -0(-X1 039-O)r.X1 040 (i = 1, 2, 3, 4, 5), OC(O)-X1041, -OC(O)-O-X1042, -OC(O)-NHX1043, -0-C(O) NX1044X1045, -OP(O)(OX1 046)(OX1 047), 15 OSi(X1048)(X1049)(X1050),

-OS(O

2 )-X1051, -NHC(O)-X1052, NX1053C(O)-X1054, -NH-C(O)-O-X1055,

-NH-C(O)-NH

X1056, -NH-C(O)-NX1057X1058, -NX1059-C(O)-O-X1060, NX1061-C(O)-NH-X1062, -NX1063-C(O)-NX1064X1065, NHS(0 2 )-X1 066, -NX1 067S(0 2 )-X1 068, -S-X1 069, -S(O) 20 X1 070, -S(0 2 )-X1 071, -S(0 2 )NH-X1 072, -S(0 2 )NX1 073X1 074, S(0 2 )O-X1075, -P(O)(OX1076)(OX1077), Si(X1 078)(X1 079)(X1 080)"; where X1029, X1030, X1031, X1032, X1033, X1034, X1035, X1036, X1037, X1038, X1039, X1040, X1041, X1042, X1043, 25 X1044, X1045, X1046, X1047, X1048, X1049, X1050, X1051, X1052, X1053, X1054, X1055, X1056, X1057, X1058, X1059, X1060, X1061, X1062, X1063, X1064, X1065, X1066, X1067, X1068, X1069, X1070, X1071, X1072, X1073, X1074, X1075, X1 076, X1077, X1078, X1 079, X1 080 are each independently 30 selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1 035, X1 036 and/or X1 044, X1 045 and/or X1 057, X1 058 and/or W02007/054556 PCT/EP2006/068322 - 29 X1064, X1065 and/or X1073, X1074, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 5 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX1081, -NX1082X1083,

-NO

2 , 10 -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1084,

-C(O)O

X1 085, -C(O)NH-X1 086, -C(O)NX1 087X1 088, -O-X1 089, O(-X1090-0)1 -H (j = 1, 2, 3, 4, 5), -O(-X1091-0)-X10 92 (j = 1, 2, 3, 4, 5), -OC(O)-X1093, -OC(O)-O-X1094,

-OC(O)

15 NHX1095, -O-C(O)-NX1096X1097, OP(O)(OX1 098)(OX1 099), -OSi(XI 1 00)(X1 101)(X1 102), OS(0 2 )-X1 103, -NHC(O)-X1104, -NX1 105C(O)-X1 106, NH-C(O)-O-X1 107, -NH-C(O)-NH-X1 108, -NH-C(O) NX1109X1110, -NX1111-C(O)-0-X11 2 , -NX1113-C(O) 20 NH-X1114, -NX1115-C(O)-NX1116X1117, -NHS(0 2

)

X1118, -NX1119S(0 2 )-X1120, -S-X1121, -S(O)-X1122, S(0 2 )-X1 123, -S(0 2 )NH-X1 124, -S(0 2 )NX1 125X1 126, S(0 2 )O-X1 127, -P(O)(OX1 128)(OX1 129), Si(X1 130)(X1 131)(X1 132)"; 25 where X1081, X1082, X1083, X1084, X1085, X1086, X1087, X1088, X1089, X1090, X1091, X1092, X1093, X1094, X1095, X1096, X1097, X1098, X1099, X1100, X1101, X1102, X1103, X1104, X1105, X1106, X1107, X1108, X1109, X1110, X1111, X1112, X1113, X1114, X1115, X1116, X1117, X1118, X1119, 30 X1120, X1121, X1122, X1123, X1124, X1125, X1126, X1127, X1128, X1129, X1130, X1131, X1132 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W02007/054556 PCT/EP2006/068322 X1087, X1088 and/or X1096, X1097 and/or X1109, X1110 and/or X1 116, X1 117 and/or X1 125, X1 126, in each case together, may also form "heterocyclyl"; 5 (m) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) X1133, -C(O)O-X1134, -C(O)-NX1135X1136, -S(0 2 )-X1137, 10 S(0 2 )O-Xl 138"; where X1133, X1134, X1135, X1136, X1137, X1138 are each independently selected from the group consisting of: hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 15 X1l135, X1136 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX1139, -NX1140XI141,

-NO

2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1 142, -C(O)O-Xl 143, C(O)NH-X1 144, -C(O)NX1 145X1 146, -O-X1147, -O(-X1 148 25 O)k-H (k = 1, 2, 3, 4, 5), -O(-X1149-0)k-X1150 (k = 1, 2, 3, 4, 5), -OC(O)-X1 151, -OC(O)-O-Xl 152, -OC(O)-NHX1 153, -0 C(O)-NX 154X1 155, -OP(O)(OX1 156)(OX1 157), OSi(X1 158)(X1 159)(X1 160), -OS(0 2 )-X1 161, -NHC(O)-X1 162, NX1 163C(O)-XI 164, -NH-C(O)-0-X1 165, -NH-C(O)-NH 30 X1166, -NH-C(O)-NX1167X1168, -NX1169-C(O)-O-X11 7 0, NX1171-C(O)-NH-X1172, -NX1173-C(O)-NX1174X1175, NHS(0 2 )-X1 176, -NX1 177S(0 2 )-X1 178, -S-X1 179, -S(O) X1l180, -S(0 2 )-X1 181, -S(0 2 )NH-X1 182, -S(0 2 )NX1 183X1 184, - W02007/054556 -31- PCT/EP2006/068322 S(0 2 )O-X1 185, -P(O)(OX1 186)(OX1 187), Si(X1 188)(X1 189)(X1 190)"; where X1139, X1140, X1141, X1142, X1143, X1 144, X1145, X1146, X1147, Xl148, X1149, X1150, X1151, X1152, X1153, 5 X1154,X1155,X1156,X1157,X1158,X1159,X11 60 ,Xll 6 l, X1162, X1163, X1164, X1165, X1166, X1167, X1168, X1169, X1170, X1171, X1172, X1173, X1174, X1175, X1176, X1177, X1178, X1179, X1180, X1181, X1182, X1183, X1184, X1185, X1186, X1187, X1188, X1189, X1190 are each independently 10 selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1 145, X1 146 and/or X1 154, X1 155 and/or X1 167, X1 168 and/or X1174, X1175 and/or X1183, X1184, in each case together, may 15 also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 20 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX1191, -NX1192X1193,

-NO

2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1 194, -C(O)O 25 X1 195, -C(O)NH-X1196, -C(O)NX1197X1198, -O-X1 199, O(-X1200-O)rH (I = 1, 2, 3, 4, 5), -O(-X1201-O)rXl20 2 (1= 1, 2, 3, 4, 5), -OC(O)-X1 203, -OC(O)-O-X1204,

-OC(O)

NHX1205, -O-C(O)-NX1206X1207, OP(O)(OX1 208)(OX1 209), -OSi(X1 21 0)(X1 211)(X1 212), 30 OS(0 2 )-X1213, -NHC(O)-X1214, -NX1215C(O)-X1216, NH-C(O)-O-X1217, -NH-C(O)-NH-X1218,

-NH-C(O)

NX1219X1220, -NX1221-C(O)-O-X1222, -NX1223-C(O) NH-X1 224, -NX1225-C(O)-NX1 226X1 227, -NHS(0 2

)

X1228, -NX1229S(O 2 )-X1230, -S-X1231, -S(O)-X1232,

-

W02007/054556 PCT/EP2006/068322 -32 S(0 2 )-X1233, -S(0 2 )NH-X1234, -S(0 2 )NX1235X1236, S(0 2 )O-X1237, -P(O)(OX1238)(OX1239), Si(X1240)(X1241)(X1242)"; where X1191, X1192, X1193, X1194, X1195, X1196, X1197, 5 X1198, X1199, X1200, X1201, X1202, X1203, X1204, X1205, X1206, X1207, X1208, X1209, X1210, X1211, X1212, X1213, X1214, X1215, X1216, X1217, X1218, X1219, X1220, X1221, X1222, X1223, X1224, X1225, X1226, X1227, X1228, X1229, X1230, X1231, X1232, X1233, X1234, X1235, X1236, X1237, 10 X1238, X1239, X1240, X1241, X1242 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1197, X1198 and/or X1206, X1207 and/or X1219, X1220 15 and/or X1226, X1227 and/or X1235, X1 236, in each case together, may also form "heterocyclyl"; or 20 (B) one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted heteroaryl", where "substituted heteroaryl" is substituted by at least one substituent selected from the group consisting of: (a) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-V1, -N(alkyl) 2 , NHC(O)-alkyl, -NHC(O)-cycloalkyl, -NHC(O)-heterocyclyl, -NHC(O)-aryl, 25 -NHC(O)-heteroaryl, -NHC(O)-arylalkyl, -NHC(O)-heteroarylalkyl, NHS(0 2 )-alkyl, -NHS(O 2 )-cycloalkyl, -NHS(0 2 )-heterocyclyl, -NHS(0 2

)

aryl, -NHS(0 2 )-heteroaryl, -NHS(0 2 )-arylalkyl, -NHS(O 2 )-heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -0-alkyl, -0-cycloalkyl, -0 cycloalkylalkyl, -0-aryl, -0-arylalkyl, -0-heteroaryl, -0-heteroarylalkyl, 30 0-heterocyclylalkyl, -OC(O)-alkyl, -OC(O)-cycloalkyl,

-OC(O)

heterocyclyl, -OC(O)-aryl, -OC(O)-heteroaryl, -OC(0)-arylalkyl,

-OC(O)

heteroarylalkyl, -OS(0 2 )-alkyl, -OS(0 2 )-cycloalkyl, -OS(O 2 )-heterocyclyl, -OS(0 2 )-aryl, -OS(0 2 )-heteroaryl, -OS(0 2 )-arylalkyl, -OS(O 2

)-

W02007/054556 -33- PCT/EP2006/068322 heteroarylalkyl, -C(O)-alkyl, -C(O)-aryl, -C(O)-heteroaryl, -C(O)O-V2, C(O)NH-V3, -C(O)N(alkyl) 2 , -C(O)N(cycloalkyl) 2 , -C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , -S(0 2 )NH-alkyl, -S(0 2 )NH-aryl, -S(0 2 )NH-heteroaryl, -S(0 2 )NH-arylalkyl, -S(0 2 )O-alkyl, -S(0 2 )O-aryl, -S(0 2 )O-arylalkyl"; 5 where V1, V2, V3 are each independently selected from the group consisting of: "alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; with the proviso that the above substituents of substituent group (a) are each independently substituted further by at least one substituent selected 10 identically or differently from the group consisting of: (i) "(Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl,

N

3 , -NH-cycloalkyl,

-NH

cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, NH-heterocyclyl, -NH-heterocyclylalkyl, -NV4V5, -S-cycloalkyl, -S 15 cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -0-cycloalkyl, -0 cycloalkylalkyl, -0-arylalkyl, -0-heteroaryl, -0-heteroarylalkyl, -0 heterocyclyl, -0-heterocyclylalkyl, -O(-V6-O)p-H (p = 1, 2, 3, 4, 5), O(-V7-O)p-V8 (p = 1, 2, 3, 4, 5), -OP(O)(OV9)(OV1 0), -C(O)O-V1 1, 20

C(O)NH

2 , -C(O)NH-V12, -C(O)NV13V14, -S(0 2 )-V15, -P(O)(OH) 2 , P(O)(OV1 6)(OV1 7), -Si(V1 8)(V1 9)(V20), -O-Si(V21)(V22)(V23), -0 C(O)-O-V24, -0-C(O)-NH-V25, -0-C(O)-NV26V27,

-NH-C(O)-

V28, -NH-C(O)-NH-V29, -NH-C(O)-NV3OV31, -NV32-C(O)-O-V33, -NV34-C(O)-NH-V35, -NV36-C(O)-NV37V38, -NV39-S(0 2 )-V40, 25

NH-S(O

2 )-V41, -O-S(0 2 )-V42, -NH-C(O)-V43, -NV44-C(O)-V45, C(O)-V46, -OC(0)-V47, -S(O)-V48, -S(0 2 )-NHV49, -S(0 2

)

NV50V51, -S(0 2 )-OV52"; with the further proviso that "-N(alkyl) 2 " is further substituted by at least one substituent selected from the following substituent group (b); 30 where V4, V5, V6, V7, V8, V9, V10, V11, V12, V13, V14, V15, V16, V17, V18, V19, V20, V21, V22, V23, V24, V25, V26, V27, V28, V29, V30, V31, V32, V33, V34, V35, V36, V37, V38, V39, V40, V41, V42, V43, V44, V45, V46, V47, V48, V49, V50, V51, V52 are each independently W02007/054556 PCT/EP2006/068322 - 34 selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V13, V14 and/or V26, V27 and/or V30, V31 and/or V37, V38 and/or V50, V51 together may also 5 form "heterocyclyl"; where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (b) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN,

CF

3 , N 3 , NH 2 , -NHV53, -NV54V55, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V56, -C(O)O-V57, -C(O)NH-V58, -C(O)NV59V60, -O-V61, -O(-V62-O)r-H (r = 1, 2, 3, 4, 5), -O(-V63-O),-V64 (r = 1, 2, 3, 4, 5), -OC(O)-V65, -OC(O) 15 O-V66, -OC(O)-NHV67, -0-C(O)-NV68V69, -OP(O)(OV70)(OV71), OSi(V72)(V73)(V74),

-OS(O

2 )-V75, -NHC(O)-V76, -NV77C(O)-V78, NH-C(O)-O-V79, -NH-C(O)-NH-V80, -NH-C(O)-NV81V82, -NV83 C(O)-0-V84, -NV85-C(O)-NH-V86, -NV87-C(O)-NV88V89, -NHS(0 2

)

V90, -NV91 S(0 2 )-V92, -S-V93, -S(O)-V94, -S(0 2 )-V95, -S(0 2 )N H-V96, 20 -S(0 2 )NV97V98, -S(0 2 )O-V99, -P(O)(OV100)(OV101), Si(V1 02)(V1 03)(V1 04)"; where V53, V54, V55, V56, V57, V58, V59, V60, V61, V62, V63, V64, V65, V66, V67, V68, V69, V70, V71, V72, V73, V74, V75, V76, V77, V78, V79, V80, V81, V82, V83, V84, V85, V86, V87, V88, V89, V90, V91, V92, V93, 25 V94, V95, V96, V97, V98, V99, V100, V101, V102, V103, V104 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V59, V60 and/or V68, V69 and/or V81, V82 and/or V88, V89 and/or V97, V98 together may also 30 form "heterocyclyl"; where, optionally, the above substituents of substituent group (b) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 -35- PCT/EP2006/068322 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV105, -NV106V107,

-NO

P(O)(OH)

2 , -C(O)-V1 08, -C(O)O-V1 09, -C(O)NH-V1 10, C(O)NV111V112, -O-V113, -O(-V114-0),-H (s = 1, 2, 3, 4, 5), -O( V115-0) 5 -V1 16 (s = 1, 2, 3, 4, 5), -OC(O)-V1 17, -OC(O)-O-Vi 18, OC(O)-NHV1 19, -O-C(O)-NV1 20V1 21, -OP(O)(OV1 22)(OV1 23), OSi(V124)(V125)(V126), -OS(0 2 )-V127, -NHC(O)-V128, 10 NV129C(O)-V130, -NH-C(O)-O-V131, -NH-C(O)-NH-V132,

-NH

C(O)-NV1 33V1 34, -NV1 35-C(O)-O-V1 36, -NV1 37-C(O)-NH-V1 38, -NV1 39-C(O)-NV1 40V1 41, -NHS(0 2 )-V1 42, -NV1 43S(0 2 )-V1 44, -S V1 45, -S(O)-V1 46, -S(0 2 )-V1 47, -S(0 2 )NH-V1 48, -S(0 2 )NV1 49V1 50, -S(0 2 )O-V1 51, -P(O)(OV1 52)(OV1 53), -Si(V1 54)(V1 55)(V1 56)"; 15 where V105, V106, V107, V108, V109, V110, V111, V11 2 , V11 3 , V114, V115, V116, V117, V118, V119, V120, V121, V122, V123, V124, V125, V126, V127, V128, V129, V130, V131, V132, V133, V134, V135, V136, V137, V138, V139, V140, V141, V142, V143, V144, V145, V146, V147, V148, V149, V150, V151, V152, V153, V154, V155, V156 are each 20 independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V111, V112 and/or V120, V121 and/or V133, V134 and/or V140, V141 and/or V149, V150 together may also form "heterocyclyl"; 25 where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1 57, -NV1 58V1 59, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V160, -C(O)O-V161, -C(O)NH-V162, C(O)NV163V164, -O-V1 65, -O(-V166-O)-H (t = 1, 2, 3, 4, 5), -O(- W02007/054556 -36- PCT/EP2006/068322 V167-O)t-V168 (t = 1, 2, 3,4, 5), -OC(O)-V169, -OC(O)-O-V170, OC(O)-NHV1 71, -O-C(O)-NV1 72V1 73, -OP(O)(OV1 74)(OV1 75), OSi(V1 76)(V1 77)(V1 78), -OS(0 2 )-V1 79, -NHC(O)-V1 80, NV1 81 C(O)-V1 82, -NH-C(O)-O-V1 83, -NH-C(O)-NH-V1 84, -NH 5 C(O)-NV1 85V1 86, -NV1 87-C(O)-O-V1 88, -NV1 89-C(O)-NH-V1 90, -NV1 91-C(O)-NV1 92V1 93, -NHS(0 2 )-V1 94, -NV1 95S(0 2 )-V1 96, -S V197, -S(O)-V1 98, -S(0 2 )-V1 99, -S(0 2 )NH-V200, -S(0 2 )NV201V202, -S(0 2 )O-V203, -P(O)(OV204)(OV205), -Si(V206)(V207)(V208)"; where V157, V158, V159, V160, V161, V162, V163, V164, V165, V166, 10 V167, V168, V169, V170, V171, V172, V173, V174, V175, V176, V177, V178, V179, V180, V181, V182, V183, V184, V185, V186, V187, V188, V189, V190, V191, V192, V193, V194, V195, V196, V197, V198, V199, V200, V201, V202, V203, V204, V205, V206, V207, V208 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, 15 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V163, V164 and/or V172, V173 and/or V185, V186 and/or V192, V193 and/or V201, V202 together may also form "heterocyclyl"; 20 or one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted heteroaryl", where "substituted heteroaryl" is substituted by at least one substituent selected identically or differently from the group consisting of: (c) "(C 9

-C

30 )alkyl, -NV209V210, -NH-(Cg-C 30 )alkyl, -NHC(O)-cycloalkylalkyl, NHC(O)-heterocyclylalkyl,

-NHC(O)-(C

9

-C

30 )alkyl, -NV21 1 C(O)-V212, 25 NV213C(O)C 9

-C

3 0)alkyl, -NHC(O)-OV214, -NV215C(O)-OV216, NHC(O)-NHV217, -NHC(O)-NV218V219, -NV220C(O)-NHV221, NV222C(O)-NV223V224, -NHS(0 2 )-cycloalkylalkyl, -NHS(0 2

)

heterocyclylalkyl, -NV225S(0 2 )-V226, -0-heterocyclyl,

-O-(C-C

30 )alkyl, S-cycloalkyl, -S-heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl,

-S

30 cycloalkylalkyl, -S-heterocyclylalkyl, -S-(Cg-C 30 )alkyl, -OC(O) cycloalkylalkyl, -OC(O)-heterocyclylalkyl,

-OC(O)-(C

9

-C

30 )alkyl, -OC(O) OV227, -OC(O)-NHV228, -OC(O)-NV229V230, -OP(O)(OV231)(OV232), -OS(0 2 )-cycloalkylalkyl,

-OS(O

2 )-heterocyclylalkyl, -OS(0 2

)-(C-C

3 0)alkyl, W02007/054556 -37- PCT/EP2006/068322 -C(O)-cycloalkyl, -C(O)-heterocyclyl, -C(O)-arylalkyl,

-C(O)

heteroarylalkyl, -C(O)-cycloalkylalkyl, -C(O)-heterocyclylalkyl, -C(O)-(C9

C

30 )alkyl, -C(O)0-(Cg-C30 )alkyl, -C(O)NH-(C 9

-C

3 0 )alkyl, -C(O)NV233V234, -C(O)NH-OV235, -C(O)NV236-OV237, -C(O)NH-NV238V239, 5 C(O)NV240-NV241V242, -S(O)-V243, -S(0 2 )-V244, -S(0 2

)NH

cycloalkyl, -S(0 2 )NH-heterocyclyl, -S(0 2 )NH-heteroarylalkyl, -S(0 2

)NH

cycloalkylalkyl, -S(0 2 )NH-heterocyclylalkyl, -S(0 2 )NH-(Cg-C 30 )alkyl, S(0 2 )0-cycloalkyl, -S(0 2 )O-heterocycly, -S(0 2 )O-heteroaryl, -S(0 2

)O

heteroarylalkyl, -S(0 2 )O-cycloalkylalkyl, -S(0 2 )O-heterocyclylalkyl, 10 S(0 2 )O-(Cg-C 30 )alkyl, -P(O)(OH) 2 , -P(O)(OV245)(OV246), Si(V247)(V248)(V249), -0-Si(V250)(V251)(V252)"; where V209, V210, V211, V212, V213, V214, V215, V216, V217, V218, V219, V220, V221, V222, V223, V224, V225, V226, V227, V228, V229, V230, V231, V232, V233, V234, V235, V236, V237, V238, V239, V240, 15 V241, V242, V243, V244, V245, V246, V247, V248, V249, V250, V251, V252 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V218, V219 and/or V223, V224 and/or V229, V230 and/or V233, V234 and/or V238, 20 V239 and/or V241, V242 together may also form "heterocycly"; with the proviso that the substituents "-N(alkyl) 2 ", "-C(O)N(alkyl) 2 ", C(O)N(cycloalkyl)2 ", "-C(O)N(aryl) 2 ", "-C(O)N(heteroaryl)2" are substituted further by at least one substituent selected from the following substituent group (i); 25 where, optionally, the above substituents of substituent group (c) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, 30 CN, CF 3 , N 3 , NH 2 , -NHV253, -NV254V255, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V256, -C(O)O-V257, -C(O)NH-V258, C(O)NV259V260, -O-V261, -O(-V262-O),-H (u = 1, 2, 3, 4, 5), -O(- W02007/054556 PCT/EP2006/068322 - 38 V263-O)u-V264 (u = 1, 2, 3, 4, 5), -OC(O)-V265, -OC(O)-O-V266, OC(O)-NHV267, -O-C(O)-NV268V269, -OP(O)(OV270)(OV271), OSi(V272)(V273)(V274), -OS(0 2 )-V275, -NHC(O)-V276, NV277C(O)-V278, -NH-C(O)-O-V279, -NH-C(O)-NH-V280,

-NH

5 C(O)-NV281V282, -NV283-C(O)-O-V284, -NV285-C(O)-NH-V286, -NV287-C(O)-NV288V289, -NHS(0 2 )-V290, -NV291S(0 2 )-V292, -S V293, -S(O)-V294, -S(0 2 )-V295, -S(0 2 )NH-V296, -S(0 2 )NV297V298, -S(0 2 )O-V299, -P(O)(OV300)(OV301), -Si(V302)(V303)(V304)"; where V253, V254, V255, V256, V257, V258, V259, V260, V261, V262, 10 V263, V264, V265, V266, V267, V268, V269, V270, V271, V272, V273, V274, V275, V276, V277, V278, V279, V280, V281, V282, V283, V284, V285, V286, V287, V288, V289, V290, V291, V292, V293, V294, V295, V296, V297, V298, V299, V300, V301, V302, V303, V304 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, 15 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V259, V260 and/or V268, V269 and/or V281, V282 and/or V288, V289 and/or V297, V298 together may also form "heterocyclyl"; where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, 20 Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (d) "alkyl, (C 9

-C

CF

3 , N 3 , NH 2 , -NHV305, -NV306V307,

-NO

2 , -OH, -OCF 3 , -SH, -0 25 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-V308, -C(O)O-V309, -C(O)NH-V31 0, -C(O)NV31 1 V312, -O-V313, -O(-V314-0),-H (v = 1, 2, 3, 4, 5), -O(-V315-O),-V316 (v = 1, 2, 3, 4, 5), -OC(O)-V317, -OC(O)-O-V318, -OC(O)-NHV319, -0-C(O) NV320V321, -OP(O)(OV322)(OV323), -OSi(V324)(V325)(V326), -OS(0 2

)

30 V327, -NHC(O)-V328, -NV329C(O)-V330, -NH-C(O)-O-V331,

-NH

C(O)-NH-V332, -NH-C(O)-NV333V334, -NV335-C(O)-O-V336, NV337-C(O)-NH-V338, -NV339-C(O)-NV34OV341, -NHS(0 2 )-V342, NV343S(0 2 )-V344, -S-V345, -S(O)-V346, -S(O 2 )-V347, -S(0 2

)NH-

W02007/054556 PCT/EP2006/068322 - 39 V348, -S(0 2 )NV349V350, -S(0 2 )O-V351, -P(O)(OV352)(OV353), Si(V354)(V355)(V356)"; where V305, V306, V307, V308, V309, V310, V311, V312, V313, V314, V315, V316, V317, V318, V319, V320, V321, V322, V323, V324, V325, 5 V326, V327, V328, V329, V330, V331, V332, V333, V334, V335, V336, V337, V338, V339, V340, V341, V342, V343, V344, V345, V346, V347, V348, V349, V350, V351, V352, V353, V354, V355, V356 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 10 heteroaryl, heteroarylalkyl" and where, alternatively, V31 1, V312 and/or V320, V321 and/or V333, V334 and/or V340, V341 and/or V349, V350 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (d) may each independently in turn be substituted by at least one substituent selected 15 identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHV357, -NV358V359,

-NO

2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 20

P(O)(OH)

2 , -C(O)-V360, -C(O)O-V361, -C(O)NH-V362, C(O)NV363V364, -O-V365, -O(-V366-0).-H (w = 1, 2, 3, 4, 5), -O( V367-0),-V368 (w = 1, 2, 3, 4, 5), -OC(O)-V369, -OC(O)-O-V370, OC(O)-NHV371, -0-C(O)-NV372V373, -OP(O)(OV374)(OV375), OSi(V376)(V377)(V378), -OS(0 2 )-V379, -NHC(O)-V380, 25 NV381C(O)-V382, -NH-C(O)-O-V383, -NH-C(O)-NH-V384,

-NH

C(O)-NV385V386, -NV387-C(O)-O-V388, -NV389-C(O)-NH-V390, -NV391-C(O)-NV392V393, -NHS(0 2 )-V394, -NV395S(0 2 )-V396, -S V397, -S(O)-V398, -S(0 2 )-V399, -S(0 2 )NH-V400, -S(0 2 )NV401V402, -S(0 2 )O-V403, -P(O)(OV404)(OV405), -Si(V406)(V407)(V408)"; 30 where V357, V358, V359, V360, V361, V362, V363, V364, V365, V366, V367, V368, V369, V370, V371, V372, V373, V374, V375, V376, V377, V378, V379, V380, V381, V382, V383, V384, V385, V386, V387, V388, V389, V390, V391, V392, V393, V394, V395, V396, V397, V398, V399, W02007/054556 PCT/EP2006/068322 -40 V400, V401, V402, V403, V404, V405, V406, V407, V408 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V363, V364 and/or 5 V372, V373 and/or V385, V386 and/or V392, V393 and/or V401, V402 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at least one substituent selected identically or differently from the group 10 consisting of: (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV409, -NV41OV411,

-NO

2 , -OH, -OCF 3 , -SH, 0-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 15

P(O)(OH)

2 , -C(O)-V412, -C(O)O-V413, -C(O)NH-V414, C(O)NV415V416, -O-V417, -O(-V418-0).-H (x = 1, 2, 3, 4, 5), -O( V419-0)-V420 (x = 1, 2, 3, 4, 5), -OC(O)-V421, -OC(O)-O-V422, OC(O)-NHV423, -0-C(O)-NV424V425, -OP(O)(OV426)(OV427), OSi(V428)(V429)(V430), -OS(0 2 )-V431, -NHC(O)-V432, 20 NV433C(O)-V434, -NH-C(O)-O-V435, -NH-C(O)-NH-V436,

-NH

C(O)-NV437V438, -NV439-C(O)-0-V440, -NV441-C(O)-NH-V442, -NV443-C(O)-NV444V445, -NHS(0 2 )-V446, -NV447S(0 2 )-V448, -S V449, -S(O)-V450, -S(0 2 )-V451, -S(0 2 )NH-V452, -S(0 2 )NV453V454, -S(0 2 )O-V455, -P(O)(OV456a)(OV456b), -Si(V456c)(V456d)(V456e)"; 25 where V409, V410, V411, V412, V413, V414, V415, V416, V417, V418, V419, V420, V421, V422, V423, V424, V425, V426, V427, V428, V429, V430, V431, V432, V433, V434, V435, V436, V437, V438, V439, V440, V441, V442, V443, V444, V445, V446, V447, V448, V449, V450, V451, V452, V453, V454, V455, V456a, V456b, V456c, V456d, V456e are 30 each independently selected from the group consisting of: "alkyl, (Ce

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V415, V416 and/or V424, V425 and/or V437, V438 and/or V444, V445 and/or V453, V454 together may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently selected from the group consisting of: (e) hydrogen; 5 (f) halogen, F, CI, Br, 1; (g) unsubstituted or substituted alkyl or (Cg-C 30 )alkyl, where, optionally, the alkyl or (Cg-C 3 0 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV457, -NV458V459,

-NO

2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V460, -C(O)O-V461, -C(O)NH-V462, C(O)NV463V464, -O-V465, -O(-V466-O)-H (y = 1, 2, 3, 4, 5), -O( 15 V467-O),-V468 (y = 1, 2, 3, 4, 5), -OC(O)-V469, -OC(O)-O-V470, OC(O)-NHV471, -O-C(O)-NV472V473, -OP(O)(OV474)(OV475), OSi(V476)(V477)(V478), -OS(0 2 )-V479, -NHC(O)-V480, NV481C(O)-V482, -NH-C(O)-O-V483, -NH-C(O)-NH-V484,

-NH

C(O)-NV485V486, -NV487-C(O)-O-V488, -NV489-C(O)-NH 20 V490, -NV491-C(O)-NV492V493, -NHS(0 2 )-V494, -NV495S(0 2

)

V496, -S-V497, -S(O)-V498, -S(0 2 )-V499, -S(0 2 )NH-V500, S(0 2 )NV501V502, -S(0 2 )O-V503, -P(O)(OV504)(OV505), Si(V506)(V507)(V508)"; where V457, V458, V459, V460, V461, V462, V463, V464, V465, 25 V466, V467, V468, V469, V470, V471, V472, V473, V474, V475, V476, V477, V478, V479, V480, V481, V482, V483, V484, V485, V486, V487, V488, V489, V490, V491, V492, V493, V494, V495, V496, V497, V498, V499, V500, V501, V502, V503, V504, V505, V506, V507, V508 are each independently selected from the group 30 consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V463, V464 and/or V472, W02007/054556 PCT/EP2006/068322 - 42 V473 and/or V485, V486 and/or V492, V493 and/or V501, V502, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 5 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV509, -NV51OV511,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 10

-SO

3 H, -P(O)(OH) 2 , -C(O)-V512, -C(O)O-V513, -C(O)NH V514, -C(O)NV515V516, -O-V517, -O(-V518-0)z-H (z = 1, 2, 3, 4, 5), -O(-V519-O),-V520 (z 1, 2, 3, 4, 5), -OC(O)-V521, OC(O)-O-V522, -OC(O)-NHV523, -0-C(O)-NV524V525, OP(O)(OV526)(OV527), -OSi(V528)(V529)(V530), -OS(0 2

)

15 V531, -NHC(O)-V532, -NV533C(O)-V534, -NH-C(O)-O-V535, -NH-C(O)-NH-V536, -NH-C(O)-NV537V538, -NV539-C(O)-0 V540, -NV541-C(O)-NH-V542, -NV543-C(O)-NV544V545, NHS(0 2 )-V546, -NV547S(0 2 )-V548, -S-V549, -S(O)-V550, S(0 2 )-V551, -S(0 2 )NH-V552, -S(0 2 )NV553V554, -S(0 2

)O

20 V555, -P(O)(OV556)(OV557), -Si(V558)(V559)(V560)"; where V509, V510, V511, V512, V513, V514, V515, V516, V517, V518, V519, V520, V521, V522, V523, V524, V525, V526, V527, V528, V529, V530, V531, V532, V533, V534, V535, V536, V537, V538, V539, V540, V541, V542, V543, V544, V545, V546, V547, 25 V548, V549, V550, V551, V552, V553, V554, V555, V556, V557, V558, V559, V560 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V515, V516 and/or V524, 30 V525 and/or V537, V538 and/or V544, V545 and/or V553, V554, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one W02007/054556 -43- PCTIEP2006/068322 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 5 Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHV561, -NV562V563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V564, -C(O)O-V565, C(O)NH-V566, -C(O)NV567V568, -O-V569, -O(-V570-0)a H (a = 1, 2, 3, 4, 5), -O(-V571-0),-V572 (a = 1, 2, 3, 4, 5), 10 OC(O)-V573, -OC(O)-O-V574, -OC(O)-NHV575, -O-C(O) NV576V577, -OP(O)(OV578)(OV579), OSi(V580)(V581)(V582),

-OS(O

2 )-V583, -NHC(O)-V584, NV585C(O)-V586, -NH-C(O)-O-V587,

-NH-C(O)-NH

V588, -NH-C(O)-NV589V590, -NV591-C(O)-O-V592, 15 NV593-C(O)-NH-V594, -NV595-C(O)-NV596V597, NHS(0 2 )-V598, -NV599S(0 2 )-V600, -S-V601, -S(O)-V602, -S(0 2 )-V603, -S(0 2 )NH-V604, -S(0 2 )NV605V606, -S(0 2

)O

V607, -P(O)(OV608)(OV609), -Si(V61 0)(V61 1)(V612)"; where V561, V562, V563, V564, V565, V566, V567, V568, 20 V569, V570, V571, V572, V573, V574, V575, V576, V577, V578, V579, V580, V581, V582, V583, V584, V585, V586, V587, V588, V589, V590, V591, V592, V593, V594, V595, V596, V597, V598, V599, V600, V601, V602, V603, V604, V605, V606, V607, V608, V609, V610, V611, V612 are each 25 independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V567, V568 and/or V576, V577 and/or V589, V590 and/or V596, V597 and/or V605, V606, in each 30 case together, may also form "heterocyclyl"; W020071054556 PCT/EP2006/068322 (h) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV613, -NV614V615, -NO 2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V616, -C(O)O-V617, -C(O)NH-V618, C(O)NV619V620, -O-V621, -O(-V622-O)b-H (b = 1, 2, 3, 4, 5), -O( 10 V623-O)b-V624 (b = 1, 2, 3, 4, 5), -OC(O)-V625, -OC(O)-O-V626, OC(O)-NHV627, -0-C(O)-NV628V629, -OP(O)(OV630)(OV631), OSi(V632)(V633)(V634), -OS(0 2 )-V635, -NHC(O)-V636, NV637C(O)-V638, -NH-C(O)-O-V639, -NH-C(O)-NH-V640,

-NH

C(O)-NV641V642, -NV643-C(O)-O-V644, -NV645-C(O)-NH 15 V646, -NV647-C(O)-NV648V649, -NHS(0 2 )-V650, -NV651 S(0 2

)

V652, -S-V653, -S(O)-V654, -S(0 2 )-V655, -S(0 2 )NH-V656, S(0 2 )NV657V658, -S(0 2 )O-V659, -P(O)(OV660)(OV661), Si(V662)(V663)(V664)"; where V613, V614, V615, V616, V617, V618, V619, V620, V621, 20 V622, V623, V624, V625, V626, V627, V628, V629, V630, V631, V632, V633, V634, V635, V636, V637, V638, V639, V640, V641, V642, V643, V644, V645, V646, V647, V648, V649, V650, V651, V652, V653, V654, V655, V656, V657, V658, V659, V660, V661, V662, V663, V664 are each independently selected from the group 25 consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V619, V620 and/or V628, V629 and/or V641, V642 and/or V648, V649 and/or V657, V658, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/0683 22 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV665, -NV666V667,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 5

-SO

3 H, -P(O)(OH) 2 , -C(O)-V668, -C(O)O-V669, -C(O)NH V670, -C(O)NV671V672, -O-V673, -O(-V674-O)c-H (c = 1, 2, 3, 4, 5), -O(-V675-0)c-V676 (c = 1, 2, 3, 4, 5), -OC(O)-V677, OC(O)-O-V678, -OC(O)-NHV679, -O-C(O)-NV680V681, OP(O)(OV682)(OV683), -OSi(V684)(V685)(V686),

-OS(O

2

)

10 V687, -NHC(O)-V688, -NV689C(O)-V690, -NH-C(O)-O-V691, -NH-C(O)-NH-V692, -NH-C(O)-NV693V694, -NV695-C(O)-O V696, -NV697-C(O)-NH-V698, -NV699-C(O)-NV700V701, NHS(O 2 )-V702, -NV703S(O 2 )-V704, -S-V705, -S(O)-V706, S(0 2 )-V707, -S(0 2 )NH-V708, -S(0 2 )NV709V710, -S(0 2

)O

15 V71 1, -P(O)(OV712)(OV713), -Si(V714)(V715)(V716)"; where V665, V666, V667, V668, V669, V670, V671, V672, V673, V674, V675, V676, V677, V678, V679, V680, V681, V682, V683, V684, V685, V686, V687, V688, V689, V690, V691, V692, V693, V694, V695, V696, V697, V698, V699, V700, V701, V702, V703, 20 V704, V705, V706, V707, V708, V709, V710, V711, V712, V713, V714, V715, V716 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V671, V672 and/or V680, 25 V681 and/or V693, V694 and/or V700, V701 and/or V709, V710, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 30 consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV717, -NV718V719,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, - W02007/054556 -46- PCT/EP2006/068322

C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V720, -C(O)O-V721, C(O)NH-V722, -C(O)NV723V724, -O-V725, -O(-V726-O)d H (d = 1, 2, 3, 4, 5), -O(-V727-O)-V728 (d = 1, 2, 3, 4, 5), OC(O)-V729, -OC(O)-O-V730, -OC(O)-NHV731, -0-C(O) 5 NV732V733, -OP(O)(OV734)(OV735), OSi(V736)(V737)(V738), -OS(0 2 )-V739, -NHC(O)-V740, NV741C(O)-V742, -NH-C(O)-O-V743,

-NH-C(O)-NH

V744, -NH-C(O)-NV745V746, -NV747-C(O)-O-V748, NV749-C(O)-NH-V750, -NV751-C(O)-NV752V753, 10 NHS(0 2 )-V754, -NV755S(0 2 )-V756, -S-V757, -S(O)-V758, -S(0 2 )-V759, -S(O 2 )NH-V760, -S(O 2 )NV761V762, -S(0 2

)O

V763, -P(O)(OV764)(OV765), -Si(V766)(V767)(V768)"; where V717, V718, V719, V720, V721, V722, V723, V724, V725, V726, V727, V728, V729, V730, V731, V732, V733, 15 V734, V735, V736, V737, V738, V739, V740, V741, V742, V743, V744, V745, V746, V747, V748, V749, V750, V751, V752, V753, V754, V755, V756, V757, V758, V759, V760, V761, V762, V763, V764, V765, V766, V767, V768 are each independently selected from the group consisting of: "alkyl, 20

(C

9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V723, V724 and/or V732, V733 and/or V745, V746 and/or V752, V753 and/or V761, V762, in each case together, may also form "heterocyclyl"; 25 (j) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHV769, -NV770V771,

-NO

2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V772, -C(O)O-V773, -C(O)NH-V774,

-

W02007/054556 PCT/EP2006/068322 -47 C(O)NV775V776, -O-V777, -O(-V778-0)-H (e = 1, 2, 3, 4, 5), -O( V779-0).-V780 (e = 1, 2, 3, 4, 5), -OC(O)-V781, -OC(O)-O-V782, OC(O)-NHV783, -0-C(O)-NV784V785, -OP(O)(OV786)(OV787), OSi(V788)(V789)(V790), -OS(0 2 )-V791, -NHC(O)-V792, 5 NV793C(O)-V794, -NH-C(O)-O-V795, -NH-C(O)-NH-V796,

-NH

C(O)-NV797V798, -NV799-C(O)-O-V800, -NV801-C(O)-NH V802, -NV803-C(O)-NV804V805,

-NHS(O

2 )-V806, -NV807S(0 2

)

V808, -S-V809, -S(O)-V810, -S(0 2 )-V811, -S(0 2 )NH-V812, S(0 2 )NV813V814, -S(0 2 )O-V815, -P(O)(OV816)(OV817), 10 Si(V818)(V819)(V820)"; where V769, V770, V771, V772, V773, V774, V775, V776, V777, V778, V779, V780, V781, V782, V783, V784, V785, V786, V787, V788, V789, V790, V791, V792, V793, V794, V795, V796, V797, V798, V799, V800, V801, V802, V803, V804, V805, V806, V807, 15 V808, V809, V810, V811, V812, V813, V814, V815, V816, V817, V818, V819, V820 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V775, V776 and/or V784, 20 V785 and/or V797, V798 and/or V804, V805 and/or V813, V814, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 25 (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV821, -NV822V823,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-V824, -C(O)O-V825,

-C(O)NH

30 V826, -C(O)NV827V828, -O-V829, -O(-V830-O)r-H (f = 1, 2, 3, 4, 5), -0(-V831-0)r-V832 (f = 1, 2, 3, 4, 5), -OC(O)-V833, OC(O)-O-V834, -OC(O)-NHV835, -0-C(O)-NV836V837, OP(O)(OV838)(OV839), -OSi(V840)(V841)(V842),

-OS(O

2

)

V843, -NHC(O)-V844, -NV845C(O)-V846, -NH-C(O)-O-V847, W02007/054556 PCT/EP2006/068322 -48 -NH-C(O)-NH-V848, -NH-C(O)-NV849V850, -NV851-C(O)-O V852, -NV853-C(O)-NH-V854, -NV855-C(O)-NV856V857, NHS(0 2 )-V858, -NV859S(0 2 )-V860, -S-V861, -S(O)-V862, S(0 2 )-V863, -S(0 2 )NH-V864, -S(0 2 )NV865V866, -S(0 2

)O

5 V867, -P(O)(OV868)(OV869), -Si(V870)(V871)(V872)"; where V821, V822, V823, V824, V825, V826, V827, V828, V829, V830, V831, V832, V833, V834, V835, V836, V837, V838, V839, V840, V841, V842, V843, V844, V845, V846, V847, V848, V849, V850, V851, V852, V853, V854, V855, V856, V857, V858, V859, 10 V860, V861, V862, V863, V864, V865, V866, V867, V868, V869, V870, V871, V872 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V827, V828 and/or V836, 15 V837 and/or V849, V850 and/or V856, V857 and/or V865, V866, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 20 consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV873, -NV874V875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 25

C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V876, -C(O)O-V877, C(O)NH-V878, -C(O)NV879V880, -O-V881, -0(-V882-O)g H (g = 1, 2, 3, 4, 5), -O(-V883-O)g-V88 4 (g = 1, 2, 3, 4, 5), OC(O)-V885, -OC(O)-O-V886, -OC(O)-NHV887, -0-C(O) NV888V889, -OP(O)(OV890)(OV891), 30 OSi(V892)(V893)(V894), -OS(0 2 )-V895, -NHC(O)-V896, NV897C(O)-V898, -NH-C(O)-0-V899, -NH-C(O)-NH V900, -N H-C(O)-NV901 V902, -NV903-C(O)-O-V904, NV905-C(O)-NH-V906, -NV907-C(O)-NV908V909, NHS(0 2 )-V91 0, -NV91 1 S(0 2 )-V912, -S-V913, -S(O)-V914, W02007/054556 PCT/EP2006/06832 2 -S(0 2 )-V915, -S(0 2 )NH-V916, -S(0 2 )NV917V918, -S(0 2

)O

V919, -P(O)(OV920)(OV921), -Si(V922)(V923)(V924)"; where V873, V874, V875, V876, V877, V878, V879, V880, V881, V882, V883, V884, V885, V886, V887, V888, V889, 5 V890, V891, V892, V893, V894, V895, V896, V897, V898, V899, V900, V901, V902, V903, V904, V905, V906, V907, V908, V909, V910, V911, V912, V913, V914, V915, V916, V917, V918, V919, V920, V921, V922, V923, V924 are each independently selected from the group consisting of: "alkyl, 10

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V879, V880 and/or V888, V889 and/or V901, V902 and/or V908, V909 and/or V917, V918, in each case together, may also form "heterocyclyl"; 15 (k) OZ6 where Z6 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 20 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV925, -NV926V927,

-NO

2 , -OH, 25

OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-V928, -C(O)O-V929,

-C(O)NH

V930, -C(O)NV931V932, -O-V933, -O(-V934-O)h-H (h = 1, 2, 3, 4, 5), -O(-V935-O)h-V 9 36 (h = 1, 2, 3, 4, 5), -OC(O)-V937, OC(O)-O-V938, -OC(O)-NHV939, -0-C(O)-NV940V941, 30 OP(O)(OV942)(OV943), -OSi(V944)(V945)(V946),

-OS(O

2

)

V947, -NHC(O)-V948, -NV949C(O)-V950, -NH-C(O)-O-V951, -NH-C(O)-NH-V952, -NH-C(O)-NV953V954, -NV955-C(O)-0 V956, -NV957-C(O)-NH-V958, -NV959-C(O)-NV960V961,

-

W02007/054556 -50- PCT/EP20061068322 NHS(0 2 )-V962, -NV963S(0 2 )-V964, -S-V965, -S(O)-V966, S(0 2 )-V967, -S(0 2 )NH-V968, -S(0 2 )NV969V970, -S(02)0 V971, -P(O)(OV972)(OV973), -Si(V974)(V975)(V976)"; where V925, V926, V927, V928, V929, V930, V931, V932, V933, 5 V934, V935, V936, V937, V938, V939, V940, V941, V942, V943, V944, V945, V946, V947, V948, V949, V950, V951, V952, V953, V954, V955, V956, V957, V958, V959, V960, V961, V962, V963, V964, V965, V966, V967, V968, V969, V970, V971, V972, V973, V974, V975, V976 are each independently selected from the group 10 consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V931, V932 and/or V940, V941 and/or V953, V954 and/or V960, V961 and/or V969, V970, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV977, -NV978V979,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V980, -C(O)O-V981, C(O)NH-V982, -C(O)NV983V984, -O-V985, -O(-V986-O)r 25 H (i = 1, 2, 3, 4, 5), -O(-V987-O)r-V988 (i = 1, 2, 3, 4, 5), OC(O)-V989, -OC(O)-O-V990, -OC(O)-NHV991, -0-C(O) NV992V993, -OP(O)(OV994)(OV995), OSi(V996)(V997)(V998), -OS(0 2 )-V999, -NHC(O)-V1 000, NV1001C(O)-V1002, -NH-C(O)-O-V1003,

-NH-C(O)-NH

30 V1004, -NH-C(O)-NV1005V1006, -NV1007-C(O)-O-V1008, -NV1009-C(O)-NH-V1010, -NV1011-C(O)-NV1012V1013, NHS(0 2 )-V1014, -NV1015S(O 2 )-V1016, -S-V1017, -S(O) V1 018, -S(0 2 )-V1 019, -S(0 2 )NH-V1 020, - W02007/054556 PCT/EP2006/068322 - 51 S(0 2 )NV1021V1022, -S(0 2 )O-V1023, P(O)(OV1 024)(OV1 025), -Si(V1026)(V1027)(V1028)"; where V977, V978, V979, V980, V981, V982, V983, V984, V985, V986, V987, V988, V989, V990, V991, V992, V993, 5 V994, V995, V996, V997, V998, V999, V1OO, V1O1, V1002, V1003, V1004, V1O5, V1006, V1007, V1008, V1009, V1OlO, V1011, V1012, V1013, V1014, V1Ol5, V1016, V1017, V1018, V1019, V1020, V1021, V1022, V1023, V1024, V1025, V1026, V1 027, V1 028 are each independently selected from the group 10 consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V983, V984 and/or V992, V993 and/or V1 005, V1 006 and/or V1 012, V1 013 and/or V1 021, V1022, in each case together, may also form 15 "heterocyclyl"; (1) SZ7 where Z7 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 20 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 25 Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1029, -NV1030V1031, -NO 2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1032, -C(O)O-V1 033, C(O)NH-V1 034, -C(O)NV1 035V1 036, -O-V1 037, -O(-V1 038 O);-H (j = 1, 2, 3, 4, 5), -O(-V1039-O)j-V1040 (j = 1, 2, 3, 4, 5), 30 OC(O)-V1041, -OC(O)-O-V1042, -OC(O)-NHV1043, -0-C(O) NV1044V1045, -OP(O)(OV1046)(OV1047), OSi(V1048)(V1049)(V1050),

-OS(O

2 )-V1051, -NHC(O)-V1052, NV1053C(O)-V1054, -NH-C(O)-O-V1055,

-NH-C(O)-NH-

W02007/054556 PCT/EP2006/068322 - 52 V1056, -NH-C(O)-NV1057V1058, -NV1059-C(O)-O-V1060, NV1061-C(O)-NH-V1062, -NV1063-C(O)-NV1064V1065, NHS(0 2 )-V1 066, -NV1 067S(0 2 )-V1 068, -S-V1 069, -S(O) V1 070, -S(0 2 )-Vl 071, -S(0 2 )NH-V1 072, -S(0 2 )NV1 073V1 074, 5 S(0 2 )O-V1 075, -P(O)(OV1 076)(OV1 077), Si(V1078)(V1079)(V1080)"; where V1029, V1030, V1031, V1032, V1033, V1034, V1035, V1036, V1037, V1038, V1039, V1040, V1041, V1042, V1043, V1044, V1045, V1046, V1 047, V1048, V1049, V1050, V1051, 10 V1052, V1053, V1054, V1055, V1056, V1057, V1058, V1059, V1060, V1061, V1062, V1063, V1064, V1065, V1066, V1067, V1068, V1069, V1070, V1071, V1072, V1073, V1074, V1075, V1 076, V1 077, V1078, V1 079, V1080 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, 15 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1 035, V1036 and/or V1044, V1045 and/or V1057, V1058 and/or V1 064, V1 065 and/or V1073, V1 074, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1081, -NV1082V1083,

-NO

2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1084,

-C(O)O

V1 085, -C(O)NH-V1 086, -C(O)NV1087V1088, -O-V1 089, 30 O(-V1090-O)k-H (k = 1, 2, 3, 4, 5), -O(-V1091-O)k-Vl0 92 (k = 1, 2, 3, 4, 5), -OC(O)-V1 093, -OC(O)-O-V1 094, -OC(0) NHV1095, -0-C(O)-NV1096V1097, OP(O)(OV1 098)(OV1 099), -OSi(Vi 1 00)(V1 101)(V1 102), OS(0 2 )-V1 103, -NHC(O)-V1 104, -NV1 105C(O)-V1 106, - W02007/054556 PCT/EP2006/06832 2 NH-C(O)-O-V1 107, -NH-C(O)-NH-V1 108, -NH-C(O) NV1109V1110, -NV1111-C(O)-O-V111 2 , -NV1113-C(O) NH-V1 114, -NV1 115-C(O)-NV1 116V1 117, -NHS(O2) V1118, -NV1119S(0 2 )-V1120, -S-V1121, -S(O)-V1122, 5 S(0 2 )-V1 123, -S(0 2 )NH-V1124, -S(0 2 )NV1125V1 126, S(0 2 )O-V1 127, -P(O)(OV1 128)(OV1 129), Si(V 130)(V1 131)(V1 132)"; where V1081, V1082, V1083, V1084, V1085, V1086, V1087, V1088, V1089, V1090, V1091, V1092, V1093, V1094, V1095, 10 V10 96 , V10 97 , V1098, V1099, V1100, V1101, V1102, V1103, V1104, V1lO5, V1106, V1107, V1108, V1109, V1llO, V1ll, V1112, V1113, V1114, V115, V1116, V1117, V1118, Vlli9, V1120, V1121, Vi122, V1123, V1124, V1125, V1126, V1127, V1128, V1129, V1130, V1131, V1132 are each independently 15 selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1087, V1088 and/or V1096, V1097 and/or V1109, V1110 and/or V1116, V1117 and/or V1125, V1126, in each case 20 together, may also form "heterocyclyl"; (m) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: (i) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) V1133, -C(O)O-V1 134, -C(O)-NV1 135V1 136, -S(0 2 )-V1 137, S(0 2 )O-V1 138"; where V1133, V1134, V1135, V1136, V1137, V1138 are each independently selected from the group consisting of: hydrogen, alkyl, 30

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1135, V1136 together may also form "heterocyclyl"; W02007/054556 PCT/EP2006/06832 2 - 54 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1139, -NV1140V1141,

-NO

2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1 142, -C(O)O-V1 143, C(O)NH-V1 144, -C(O)NV1145V1 146, -O-V1 147, -O(-V1 148 10 O)r-H (I = 1, 2, 3, 4, 5), -O(-V1149-O)rVl150 (I = 1, 2, 3, 4, 5), OC(O)-V1 151, -OC(O)-O-V1 152, -OC(O)-NHV1 153, -O-C(O) NV1 154V1 155, -OP(O)(OV 156)(OV1 157), OSi(V1 158)(V1 159)(V1 160), -OS(0 2 )-V1 161, -NHC(O)-V1 162, NV1 163C(O)-V1 164, -NH-C(O)-O-V1 165, -NH-C(O)-NH 15 V1166, -NH-C(O)-NV1167V1168, -NV1169-C(O)-O-V11 7 0, NV1171-C(O)-NH-V1172, -NV1173-C(O)-NV1174V1175, NHS(0 2 )-V1 176, -NV1 177S(0 2 )-V1 178, -S-V1 179, -S(O) V1180, -S(0 2 )-V1 181, -S(0 2 )NH-V1 182, -S(0 2 )NV1 183V1 184, S(0 2 )O-V1 185, -P(O)(OV1 186)(OV1 187), 20 Si(V1 188)(V1 189)(V1 190)"; where V1139, V1140, V1141, V1142, V1143, V1144, V1145, V1146, V1147, V1148, V1149, V1150, V1151, V1152, V1153, V1154, V1155, V1156, V1157, V1158, V1159, V1160, V1161, V1162, V1163, V1164, V1165, V1166, V1167, V1168, V1169, 25 V11 7 0,Vll 7 l,V1172,V1173,V1174,V1175,V1176,V1177, V1178, V1179, V1180, V1181, V1182, V1183, V1184, V1185, V1 186, V1 187, V1 188, V1 189, V1 190 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 30 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1145, V1146 and/or V1154, V1155 and/or V1167, V1 168 and/or V1174, V1175 and/or V1i183, V1i184, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -55 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1 191, -NVi 192V1 193, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1194, -C(0)0 10 V1195, -C(O)NH-V1196, -C(O)NV1197V1198, -O-V1199, O(-V1200-0)m-H (m = 1, 2, 3, 4, 5), -O(-V1201-0)m-V1202 (m = 1, 2, 3, 4, 5), -OC(O)-V1203, -OC(O)-O-V1204, OC(O)-NHV1 205, -O-C(O)-NV1206V1207, OP(O)(OV1 208)(OV1209), -OSi(V1 21 0)(V1 211)(V1 212), 15

OS(O

2 )-V1213, -NHC(O)-V1214, -NV1215C(O)-V1216, NH-C(O)-O-V1217, -NH-C(O)-NH-V1218,

-NH-C(O)

NV1219V1220, -NV1221-C(O)-O-V1222, -NV1223-C(O) NH-V1224, -NV1225-C(O)-NV1226V1227, -NHS(0 2

)

V1228, -NV1229S(0 2 )-V1230, -S-V1231, -S(O)-V1232, 20 S(0 2 )-V1 233, -S(0 2 )NH-V1234, -S(0 2 )NV1235V1236, S(0 2 )O-V1237, -P(O)(OV1238)(OV1239), Si(V1 240)(V1 241)(V1242)"; where V1191, V1192, V1193, V1194, V1195, V1196, V1197, V1198, V1199, V1200, V1201, V1202, V1203, V1204, V1205, 25 V1206, V1207, V1208, V1209, V1210, V1211, V1212, V1213, V1214, V1215, V1216, V1217, V1218, V1219, V1220, V1221, V1222, V1223, V1224, V1225, V1226, V1227, V1228, V1229, V1230, V1231, V1232, V1233, V1234, V1235, V1236, V1237, V1238, V1239, V1240, V1241, V1242 are each independently 30 selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1197, V1198 and/or V1206, V1207 and/or V1219, V1220 W02007/054556 -56- PCT/EP2006/068322 and/or V1226, V1227 and/or V1235, V1236, in each case together, may also form "heterocyclyl"; or 5 (C) one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted alkyl", where "substituted alkyl" is substituted by at least one substituent selected from the group consisting of: (a) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW1, -NW2W3, -NO 2 , -OH, -OCF 3 , -SH, -0

SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-W4, -C(O)O-W5, -C(O)NH-W6, -C(O)NW7W8, -O-W9, -O( W10-O)rH (r = 1, 2, 3, 4, 5), -O(-W11-O)r-W12 (r = 1, 2, 3, 4, 5), 15 OC(O)-W13, -OC(O)-O-W14, -OC(O)-NHW15, -O-C(O)-NW16W17, OP(O)(OW18)(OW19), -OSi(W20)(W21)(W22), -OS(0 2 )-W23, NHC(O)-W24, -NW25C(O)-W26, -NH-C(O)-O-W27,

-NH-C(O)-NH

W28, -NH-C(O)-NW29W30, -NW31-C(O)-O-W32, -NW33-C(O)-NH W34, -NW35-C(O)-NW36W37, -NHS(0 2 )-W38, -NW39S(0 2 )-W40, 20 S-W41, -S(O)-W42, -S(0 2 )-W43, -S(O 2 )NH-W44, -S(0 2 )NW45W46, S(0 2 )O-W47, -P(O)(OW48)(OW49), -Si(W50)(W51)(W52)"; where W1, W2, W3, W4, W5, W6, W7, W8, W9, W10, W11, W12, W13, W14, W15, W16, W17, W18, W19, W20, W21, W22, W23, W24, W25, W26, W27, W28, W29, W30, W31, W32, W33, W34, W35, W36, W37, 25 W38, W39, W40, W41, W42, W43, W44, W45, W46, W47, W48, W49, W50, W51, W52 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W7, W8 and/or W16, W17 and/or W29, W30 and/or W36, 30 W37 and/or W45, W46, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -57 with the proviso that "-C(O)NH-aryl", "-C(O)NH-heteroaryl", "-C(O)NH cycloalkyl", "-C(O)NH-heterocyclyl" are substituted further by at least one substituent selected from the following substitution group (i); where, optionally, the above substituents of substituent group (a) may in 5 turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW53, -NW54W55, -NO 2 , -OH, -OCF 3 , -SH, 10 O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W56, -C(O)O-W57, -C(O)NH-W58, C(O)NW59W60, -O-W61, -O(-W62-0),-H (s = 1, 2, 3, 4, 5), -O( W63-O)t-W64 (t = 1, 2, 3, 4, 5), -OC(O)-W65, -OC(O)-O-W66, OC(O)-NHW67, -0-C(O)-NW68W69, -OP(O)(OW70)(OW71), 15 OSi(W72)(W73)(W74), -OS(0 2 )-W75, -NHC(O)-W76, -NW77C(O) W78, -NH-C(O)-O-W79, -NH-C(O)-NH-W80, -NH-C(O) NW81W82, -NW83-C(O)-O-W84, -NW85-C(O)-NH-W86, -NW87 C(O)-NW88W89, -NHS(O 2 )-W90, -NW91 S(0 2 )-W92, -S-W93, S(O)-W94, -S(O 2 )-W95, -S(O 2 )NH-W96, -S(O 2 )NW97W98, 20 S(0 2 )O-W99, -P(O)(OW100)(OW101), -Si(W102)(W103)(W104)"; where W53, W54, W55, W56, W57, W58, W59, W60, W61, W62, W63, W64, W65, W66, W67, W68, W69, W70, W71, W72, W73, W74, W75, W76, W77, W78, W79, W80, W81, W82, W83, W84, W85, W86, W87, W88, W89, W90, W91, W92, W93, W94, W95, W96, W97, W98, 25 W99, W100, W101, W102, W103, W104 are each independently selected from the group consisting of: "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W59, W60 and/or W68, W69 and/or W81, W82 and/or W88, W89 and/or W97, W98, in 30 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 -58 (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW105, -NW106W107,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 5

C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W108, -C(O)O-W109, -C(O)N H-W 110, -C(O)NW 111 W112, -O-W 113, -O(-W 114 O)t-H (t = 1, 2, 3, 4, 5), -O(-W115-O)r-W116 (t = 1, 2, 3, 4, 5), -OC(O)-W1 17, -OC(O)-O-W1 18, -OC(O)-NHW1 19, -0 C(O)-NW120W121, -OP(O)(OW122)(OW123), 10 OSi(W124)(W125)(W126), -OS(0 2 )-W127, -NHC(O)-W128, -NW 129C(O)-W130, -NH-C(O)-O-W 131, -N H-C(O)-NH W132, -NH-C(O)-NW133W134, -NW135-C(O)-O-W136, NW1 37-C(O)-NH-W138, -NW1 39-C(O)-NW140W 141, NHS(0 2 )-W142, -NW143S(0 2 )-W144, -S-W145, -S(O) 15 W146, -S(0 2 )-W147, -S(0 2 )NH-W148, -S(0 2 )NW149W150, -S(0 2 )O-W151, -P(O)(OW152)(OW153), Si(W154)(W155)(W156)"; where W105, W106, W107, W108, W109, W110, W111, W1 12, W1 13, W1 14, W1 15, W1 16, W1 17, W1 18, W1 19, 20 W120, W121, W122, W123, W124, W125, W126, W127, W128, W129, W130, W131, W132, W133, W134, W135, W136, W137, W138, W139, W140, W141, W142, W143, W144, W145, W146, W147, W148, W149, W150, W151, W152, W153, W154, W155, W156 are each independently 25 selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W111, W112 and/or W120, W121 and/or W133, W134 and/or W140, W141 and/or W149, W150, in each case together, may 30 also form "heterocyclyl"; or one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "(C

C

30 )alkyl"; W02007/054556 -59- PCT/EP2006/068322 where "(Cg-C 30 )alkyl" may independently optionally be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, 5 CF 3 , N 3 , NH 2 , -NHW157, -NW158W159, -NO 2 , -OH, -OCF 3 , -SH, -0

SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-W160, -C(O)O-W161, -C(O)NH-W162, -C(O)NW163W164, -0 W165, -O(-W166-O)u-H (u = 1, 2, 3, 4, 5), -O(-W167-O),-W168 (u = 1, 2, 3,4, 5), -OC(O)-W169, -OC(0)-O-W170, -OC(O)-NHW171, -0 10 C(O)-NW172W173, -OP(O)(OW174)(OW175), -OSi(W176)(W177)(W178), -OS(0 2 )-W179, -NHC(O)-W180, -NW181 C(O)-W182, -NH-C(O)-O W183, -NH-C(O)-NH-W184, -NH-C(O)-NW185W186, -NW187-C(O) O-W188, -NW189-C(O)-NH-W190, -NW191-C(O)-NW192W193, NHS(0 2 )-W194, -NW1 95S(0 2 )-W196, -S-W197, -S(O)-W198, -S(02) 15 W199, -S(0 2 )NH-W200, -S(0 2 )NW201W202, -S(0 2 )O-W203, P(O)(OW204)(OW205), -Si(W206)(W207)(W208)"; where W157, W158, W159, W160, W161, W162, W163, W164, W165, W166, W167, W168, W169, W170, W171, W172, W173, W174, W175, W176, W177, W178, W179, W180, W181, W182, W183, W184, W185, 20 W186, W187, W188, W189, W190, W191, W192, W193, W194, W195, W196, W197, W198, W199, W200, W201, W202, W203, W204, W205, W206, W207, W208 are each independently selected from the group consisting of: "alkyl, (Cg-C3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, 25 alternatively, W163, W164 and/or W172, W173 and/or W185, W186 and/or W192, W193 and/or W201, W202, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected 30 identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW209, -NW21OW21 1, -NO 2 , -OH, -OCF 3 , -SH, W02007/054556 -60- PCT/EP2006/068322

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W212, -C(O)O-W213, -C(O)NH-W214, C(O)NW215W216, -O-W217, -O(-W218-O),-H (v = 1, 2, 3, 4, 5), O(-W219-0),-W220 (v = 1, 2, 3, 4, 5), -OC(O)-W221, -OC(O)-0 5 W222, -OC(O)-NHW223, -0-C(O)-NW224W225, OP(O)(OW226)(OW227), -OSi(W228)(W229)(W230),

-OS(O

2 )-W231, -NHC(O)-W232, -NW233C(O)-W234, -NH-C(O)-O-W235,

-NH

C(O)-NH-W236, -NH-C(O)-NW237W238, -NW239-C(O)-O-W240, NW241-C(O)-NH-W242, -NW243-C(O)-NW244W245, -NHS(0 2

)

10 W246, -NW247S(O 2 )-W248, -S-W249, -S(O)-W250, -S(O 2 )-W251, S(O 2 )NH-W252, -S(0 2 )NW253W254, -S(0 2 )O-W255, P(O)(OW256)(OW257), -Si(W258)(W259)(W260)"; where W209, W210, W211, W212, W213, W214, W215, W216, W217, W218, W219, W220, W221, W222, W223, W224, W225, W226, W227, 15 W228, W229, W230, W231, W232, W233, W234, W235, W236, W237, W238, W239, W240, W241, W242, W243, W244, W245, W246, W247, W248, W249, W250, W251, W252, W253, W254, W255, W256, W257, W258, W259, W260 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 20 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W215, W216 and/or W224, W225 and/or W237, W238 and/or W244, W245 and/or W253, W254, in each case together, may also form "heterocyclyl"; 25 and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently selected from the group consisting of: (b) hydrogen; (c) halogen, F, Cl, Br, 1; (d) unsubstituted or substituted alkyl or (C 9

-C

30 )alkyl, where, optionally, the 30 alkyl or (C9-C 30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, W02007/054556 PCT/EP2006/068322 CN, CF 3 , N 3 , NH 2 , -NHW457, -NW458W459, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W460, -C(O)O-W461, -C(O)NH-W462, C(O)NW463W464, -O-W465, -O(-W466-0)x-H (x = 1, 2, 3, 4, 5), 5 O(-W467-0)k-W468 (x = 1, 2, 3, 4, 5), -OC(O)-W469, -OC(O)-O W470, -OC(O)-NHW471, -0-C(O)-NW472W473, OP(O)(OW474)(OW475), -OSi(W476)(W477)(W478), -OS(0 2

)

W479, -NHC(O)-W480, -NW481C(O)-W482, -NH-C(O)-O-W483, NH-C(O)-NH-W484, -NH-C(O)-NW485W486, -NW487-C(O)-O 10 W488, -NW489-C(O)-NH-W490, -NW491-C(O)-NW492W493, NHS(O 2 )-W494, -NW495S(0 2 )-W496, -S-W497, -S(O)-W498, S(0 2 )-W499, -S(O 2 )NH-W500, -S(O 2 )NW501W502, -S(0 2 )O-W503, -P(O)(OW504)(OW505), -Si(W506)(W507)(W508)"; where W457, W458, W459, W460, W461, W462, W463, W464, W465, 15 W466, W467, W468, W469, W470, W471, W472, W473, W474, W475, W476, W477, W478, W479, W480, W481, W482, W483, W484, W485, W486, W487, W488, W489, W490, W491, W492, W493, W494, W495, W496, W497, W498, W499, W500, W501, W502, W503, W504, W505, W506, W507, W508 are each 20 independently selected from the group consisting of: "alkyl, (Cs

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W463, W464 and/or W472, W473 and/or W485, W486 and/or W492, W493 and/or W501, W502, in each case together, may also form 25 "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, C, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW509, -NW51OW511, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-W512, -C(O)O-W513, -C(O)NH W514, -C(O)NW515W516, -O-W517, -O(-W518-O)y-H (y = 1, W020071054556 PCT/EP2006/068322 - 62 2, 3, 4, 5), -O(-W519-O)y-W520 (y = 1, 2, 3, 4, 5), -OC(O) W521, -OC(O)-O-W522, -OC(O)-NHW523,

-O-C(O)

NW524W525, -OP(O)(OW526)(OW527), OSi(W528)(W529)(W530), -OS(0 2 )-W531, -NHC(O)-W532, 5 NW533C(O)-W534, -NH-C(O)-0-W535, -NH-C(O)-NH-W536, -NH-C(O)-NW537W538, -NW539-C(O)-O-W540, -NW541 C(O)-NH-W542, -NW543-C(O)-NW544W545, -NHS(0 2 )-W546, -NW547S(0 2 )-W548, -S-W549, -S(O)-W550, -S(0 2 )-W551, S(0 2 )NH-W552, -S(0 2 )NW553W554, -S(0 2 )O-W555, 10 P(O)(OW556)(OW557), -Si(W558)(W559)(W560)"; where W509, W51 0, W51 1, W512, W513, W514, W515, W516, W517, W518, W519, W520, W521, W522, W523, W524, W525, W526, W527, W528, W529, W530, W531, W532, W533, W534, W535, W536, W537, W538, W539, W540, W541, W542, W543, 15 W544, W545, W546, W547, W548, W549, W550, W551, W552, W553, W554, W555, W556, W557, W558, W559, W560 are each independently selected from the group consisting of: "alkyl, (Cq

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 20 W515, W516 and/or W524, W525 and/or W537, W538 and/or W544, W545 and/or W553, W554, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 25 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF3, N 3 , NH 2 , -NHW561, -NW562W563, -NO 2 , 30 -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W564, -C(O)O-W565, -C(O)NH-W566, -C(O)NW567W568, -0-W569, -0(-W570 O),-H (z = 1, 2, 3, 4, 5), -0(-W571-0)f-W572 (z = 1, 2, 3, 4, 5), -OC(O)-W573, -OC(O)-O-W574, -OC(O)-NHW575, -0- W02007/054556 -63- PCT/EP2006/068322 C(O)-NW576W577, -OP(O)(OW578)(OW579), OSi(W580)(W581)(W582), -OS(0 2 )-W583, -NHC(O)-W584, -NW585C(O)-W586, -NH-C(O)-O-W587,

-NH-C(O)-NH

W588, -NH-C(O)-NW589W590, -NW591-C(O)-O-W592, 5 NW593-C(O)-NH-W594, -NW595-C(O)-NW596W597, NHS(0 2 )-W598, -NW599S(0 2 )-W600, -S-W601, -S(O) W602, -S(0 2 )-W603, -S(0 2 )NH-W604, -S(0 2 )NW605W606, -S(0 2 )O-W607, -P(O)(OW608)(OW609), Si(W61 0)(W61 1)(W612)"; 10 where W561, W562, W563, W564, W565, W566, W567, W568, W569, W570, W571, W572, W573, W574, W575, W576, W577, W578, W579, W580, W581, W582, W583, W584, W585, W586, W587, W588, W589, W590, W591, W592, W593, W594, W595, W596, W597, W598, W599, 15 W600, W601, W602, W603, W604, W605, W606, W607, W608, W609, W610, W611, W612 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 20 W567, W568 and/or W576, W577 and/or W589, W590 and/or W596, W597 and/or W605, W606, in each case together, may also form "heterocyclyl"; (e) unsubstituted or substituted aryl where, optionally, the aryl radical may be 25 substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW613, -NW614W615, -NO 2 , -OH, -OCF 3 , 30 SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W616, -C(O)O-W617, -C(O)NH-W618, C(O)NW619W620, -0-W621, -0(-W622-0)a-H (a = 1, 2, 3, 4, 5), O(-W623-0)a-W624 (a = 1, 2, 3, 4, 5), -OC(O)-W625, -OC(O)-O- W02007/054556 PCT/EP2006/068322 - 64 W626, -OC(O)-NHW627, -0-C(O)-NW628W629, OP(O)(OW630)(OW631), -OSi(W632)(W633)(W634), -OS(0 2

)

W635, -NHC(O)-W636, -NW637C(O)-W638, -NH-C(O)-O-W639, NH-C(O)-NH-W640, -NH-C(O)-NW641W642, -NW643-C(O)-O 5 W644, -NW645-C(O)-NH-W646, -NW647-C(O)-NW648W649, NHS(O 2 )-W650, -NW651S(0 2 )-W652, -S-W653, -S(O)-W654, S(0 2 )-W655, -S(O 2 )NH-W656, -S(0 2 )NW657W658, -S(0 2 )O-W659, -P(O)(OW660)(OW661), -Si(W662)(W663)(W664)"; where W613, W614, W615, W616, W617, W618, W619, W620, W621, 10 W622, W623, W624, W625, W626, W627, W628, W629, W630, W631, W632, W633, W634, W635, W636, W637, W638, W639, W640, W641, W642, W643, W644, W645, W646, W647, W648, W649, W650, W651, W652, W653, W654, W655, W656, W657, W658, W659, W660, W661, W662, W663, W664 are each 15 independently selected from the group consisting of: "alkyl, (C

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W619, W620 and/or W628, W629 and/or W641, W642 and/or W648, W649 and/or W657, W658, in each case together, may also form 20 "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW665, -NW666W667, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH)2, -C(O)-W668, -C(O)O-W669,

-C(O)NH

W670, -C(O)NW671W672, -O-W673, -O(-W674-O)b-H (b = 1, 30 2, 3, 4, 5), -O(-W675-O)-W676 (b = 1, 2, 3, 4, 5), -OC(O) W677, -OC(O)-O-W678, -OC(O)-NHW679, -0-C(O) NW680W681, -OP(O)(OW682)(OW683), OSi(W684)(W685)(W686), -OS(0 2 )-W687, -NHC(O)-W688, NW689C(O)-W690, -NH-C(O)-O-W691, -NH-C(O)-NH-W692, W02007/054556 PCT/EP2006/068322 -65 -NH-C(O)-NW693W694, -NW695-C(O)-O-W696, -NW697 C(O)-NH-W698, -NW699-C(O)-NW700W701,

-NHS(O

2 )-W702, -NW703S(0 2 )-W704, -S-W705, -S(O)-W706, -S(O 2 )-W707, S(O 2 )NH-W708, -S(0 2 )NW709W71 0, -S(02)O-W71 1, 5 P(O)(OW712)(OW713), -Si(W714)(W715)(W716)"; where W665, W666, W667, W668, W669, W670, W671, W672, W673, W674, W675, W676, W677, W678, W679, W680, W681, W682, W683, W684, W685, W686, W687, W688, W689, W690, W691, W692, W693, W694, W695, W696, W697, W698, W699, 10 W700, W701, W702, W703, W704, W705, W706, W707, W708, W709, W710, W711, W712, W713, W714, W715, W716 are each independently selected from the group consisting of: "alkyl, (C9

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 15 W671, W672 and/or W680, W681 and/or W693, W694 and/or W700, W701 and/or W709, W710, in each case together, may also form "heterocycly"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 20 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW717, -NW718W719, -NO 2 , 25 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W720, -C(O)O-W721, -C(O)NH-W722, -C(O)NW723W724, -O-W725, -O(-W726 O)c-H (c = 1, 2, 3, 4, 5), -O(-W727-O)c-W728 (c = 1, 2, 3, 4, 5), -OC(O)-W729, -OC(O)-O-W730, -OC(O)-NHW731, -0 30 C(O)-NW732W733, -OP(O)(OW734)(OW735), OSi(W736)(W737)(W738), -OS(0 2 )-W739, -NHC(O)-W740, -NW741 C(O)-W742, -NH-C(O)-O-W743,

-NH-C(O)-NH

W744, -NH-C(O)-NW745W746, -NW747-C(O)-O-W748, NW749-C(O)-NH-W750, -NW751-C(O)-NW752W753,

-

W02007/054556 -66- PCT/EP2006/068322 NHS(0 2 )-W754, -NW755S(0 2 )-W756, -S-W757, -S(O) W758, -S(0 2 )-W759, -S(0 2 )NH-W760, -S(0 2 )NW761W762, -S(0 2 )O-W763, -P(O)(OW764)(OW765), Si(W766)(W767)(W768)"; 5 where W717, W718, W719, W720, W721, W722, W723, W724, W725, W726, W727, W728, W729, W730, W731, W732, W733, W734, W735, W736, W737, W738, W739, W740, W741, W742, W743, W744, W745, W746, W747, W748, W749, W750, W751, W752, W753, W754, W755, 10 W756, W757, W758, W759, W760, W761, W762, W763, W764, W765, W766, W767, W768 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 15 W723, W724 and/or W732, W733 and/or W745, W746 and/or W752, W753 and/or W761, W762, in each case together, may also form "heterocyclyl"; (f) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl 20 radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW769, -NW770W771, -NO 2 , -OH, -OCF 3 , 25 SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W772, -C(O)O-W773, -C(O)NH-W774, C(O)NW775W776, -O-W777, -O(-W778-O)d-H (d = 1, 2, 3, 4, 5), O(-W779-O)d-W 78 0 (d = 1, 2, 3, 4, 5), -OC(O)-W781,

-OC(O)-O

W782, -OC(O)-NHW783, -O-C(O)-NW784W785, 30 OP(O)(OW786)(OW787), -OSi(W788)(W789)(W790), -OS(0 2

)

W791, -NHC(O)-W792, -NW793C(O)-W794, -NH-C(O)-O-W795, NH-C(O)-NH-W796, -NH-C(O)-NW797W798, -NW799-C(O)-O W800, -NW801-C(O)-NH-W802, -NW803-C(O)-NW804W805,

-

W02007/054556 PCT/EP2006/068322 - 67 NHS(0 2 )-W806, -NW807S(0 2 )-W808, -S-W809, -S(O)-W810, S(0 2 )-W81 1, -S(0 2 )NH-W812, -S(0 2 )NW813W814, -S(0 2 )O-W815, -P(O)(OW816)(OW817), -Si(W818)(W819)(W820)"; where W769, W770, W771, W772, W773, W774, W775, W776, W777, 5 W778, W779, W780, W781, W782, W783, W784, W785, W786, W787, W788, W789, W790, W791, W792, W793, W794, W795, W796, W797, W798, W799, W800, W801, W802, W803, W804, W805, W806, W807, W808, W809, W810, W811, W812, W813, W814, W815, W816, W817, W818, W819, W820 are each 10 independently selected from the group consisting of: "alkyl, (C

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W775, W776 and/or W784, W785 and/or W797, W798 and/or W804, W805 and/or W813, W814, in each case together, may also form 15 "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW821, -NW822W823,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-W824, -C(O)O-W825,

-C(O)NH

W826, -C(O)NW827W828, -0-W829, -0(-W830-0)e-H (e = 1, 25 2, 3, 4, 5), -0(-W831-0)-W832 (e = 1, 2, 3, 4, 5), -OC(O) W833, -OC(O)-O-W834, -OC(O)-NHW835, -0-C(0) NW836W837, -OP(O)(OW838)(OW839), OSi(W840)(W841)(W842), -OS(0 2 )-W843, -NHC(O)-W844, NW845C(O)-W846, -NH-C(O)-O-W847, -NH-C(O)-NH-W848, 30 -NH-C(O)-NW849W850, -NW851-C(O)-O-W852, -NW853 C(O)-NH-W854, -NW855-C(O)-NW856W857, -NHS(0 2 )-W858, -NW859S(0 2 )-W860, -S-W861, -S(O)-W862, -S(0 2 )-W863, S(0 2 )NH-W864, -S(0 2 )NW865W866, -S(0 2 )0-W867, P(O)(OW868)(OW869), -Si(W870)(W871)(W872)"; W02007/054556 PCT/EP2006/068322 - 68 where W821, W822, W823, W824, W825, W826, W827, W828, W829, W830, W831, W832, W833, W834, W835, W836, W837, W838, W839, W840, W841, W842, W843, W844, W845, W846, W847, W848, W849, W850, W851, W852, W853, W854, W855, 5 W856, W857, W858, W859, W860, W861, W862, W863, W864, W865, W866, W867, W868, W869, W870, W871, W872 are each independently selected from the group consisting of: "alkyl, (C 9 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 10 W827, W828 and/or W836, W837 and/or W849, W850 and/or W856, W857 and/or W865, W866, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 15 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW873, -NW874W875, -NO 2 , 20 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W876, -C(O)O-W877, -C(O)NH-W878, -C(O)NW879W880, -O-W881, -O(-W882 O)r-H (f = 1, 2, 3, 4, 5), -O(-W883-O)r-W884 (f = 1, 2, 3, 4, 5), -OC(O)-W885, -OC(O)-O-W886, -OC(O)-NHW887, -0 25 C(O)-NW888W889, -OP(O)(OW890)(OW891), OSi(W892)(W893)(W894), -OS(0 2 )-W895, -NHC(O)-W896, -NW897C(O)-W898, -NH-C(O)-O-W899,

-NH-C(O)-NH

W900, -NH-C(O)-NW901W902, -NW903-C(O)-O-W904, NW905-C(O)-NH-W906, -NW907-C(O)-NW908W909, 30 NHS(0 2 )-W910, -NW911S(0 2 )-W912, -S-W913, -S(O) W914, -S(0 2 )-W915, -S(0 2 )NH-W916, -S(0 2 )NW917W918, -S(0 2 )O-W919, -P(O)(OW920)(OW921), Si(W922)(W923)(W924)"; W02007/054556 -69- PCT/EP2006/068322 where W873, W874, W875, W876, W877, W878, W879, W880, W881, W882, W883, W884, W885, W886, W887, W888, W889, W890, W891, W892, W893, W894, W895, W896, W897, W898, W899, W900, W901, W902, W903, 5 W904, W905, W906, W907, W908, W909, W910, W91 1, W912, W913, W914, W915, W916, W917, W918, W919, W920, W921, W922, W923, W924 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 10 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W879, W880 and/or W888, W889 and/or W901, W902 and/or W908, W909 and/or W917, W918, in each case together, may also form "heterocyclyl"; 15 (g) OZ6 where Z6 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 20 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW925, -NW926W927,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 25

-SO

3 H, -P(O)(OH) 2 , -C(O)-W928, -C(O)O-W929, -C(O)NH W930, -C(O)NW931W932, -0-W933, -O(-W934-0)g-H (g = 1, 2, 3, 4, 5), -O(-W935-O)g-W936 (g = 1, 2, 3, 4, 5), -OC(O) W937, -OC(O)-O-W938, -OC(O)-NHW939, -0-C(0) NW940W941, -OP(O)(OW942)(OW943), 30 OSi(W944)(W945)(W946), -OS(0 2 )-W947, -NHC(O)-W948, NW949C(O)-W950, -NH-C(O)-0-W951, -NH-C(O)-NH-W952, -NH-C(O)-NW953W954, -NW955-C(O)-O-W956, -NW957 C(O)-NH-W958, -NW959-C(O)-NW960W961, -NHS(0 2 )-W962, W02007/054556 -70- PCT/EP2006/068322 -NW963S(0 2 )-W964, -S-W965, -S(O)-W966, -S(0 2 )-W967, S(0 2 )NH-W968, -S(0 2 )NW969W970, -S(0 2 )O-W971, P(O)(OW972)(OW973), -Si(W974)(W975)(W976)"; where W925, W926, W927, W928, W929, W930, W931, W932, 5 W933, W934, W935, W936, W937, W938, W939, W940, W941, W942, W943, W944, W945, W946, W947, W948, W949, W950, W951, W952, W953, W954, W955, W956, W957, W958, W959, W960, W961, W962, W963, W964, W965, W966, W967, W968, W969, W970, W971, W972, W973, W974, W975, W976 are each 10 independently selected from the group consisting of: "alkyl, (Cs

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W931, W932 and/or W940, W941 and/or W953, W954 and/or W960, W961 and/or W969, W970, in each case together, may also 15 form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 20 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW977, -NW978W979, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W980, -C(O)O-W981, 25 -C(O)NH-W982, -C(O)NW983W984, -O-W985, -O(-W986 O)h-H (h = 1, 2, 3, 4, 5), -O(-W987-O)h-W988 (h = 1, 2, 3, 4, 5), -OC(O)-W989, -OC(O)-O-W990, -OC(O)-NHW991, -0 C(O)-NW992W993, -OP(O)(OW994)(OW995), OSi(W996)(W997)(W998), -OS(0 2 )-W999, -NHC(O)-W1000, 30 -NW1001 C(O)-W1002, -NH-C(O)-O-W1003,

-NH-C(O)

NH-W1004, -NH-C(O)-NW1005W1006, -NW1007-C(O)-O W1008, -NW1009-C(O)-NH-W1010, -NW1011-C(O) NW1012W1013, -NHS(0 2 )-W1014, -NW1015S(O 2 )-W1016, -S-W1017, -S(O)-W1018, -S(0 2 )-W1019, -S(0 2

)NH-

W02007/054556 PCT/EP2006/068322 - 71 W1020, -S(0 2 )NW1021W1022, -S(0 2 )O-W1023, P(O)(OW1024)(OW1025), -Si(W1026)(W1027)(W1028)"; where W977, W978, W979, W980, W981, W982, W983, W984, W985, W986, W987, W988, W989, W990, W991, 5 W992, W993, W994, W995, W996, W997, W998, W999, W1000, W1001, W1002, W1003, W1004, W1005, W1006, W1007, W1008, W1009, W1010, W1011, W1012, W1013, W1014, W1015, W1016, W1017, W1018, W1019, W1020, W1021, W1022, W1023, W1024, W1025, W1026, W1027, 10 W1028 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W983, W984 and/or W992, W993 and/or W1005, W1006 and/or W1012, W1013 15 and/or W1021, W1022, in each case together, may also form "heterocycly"; (h) SZ7 where Z7 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1029, -NW1030W1031, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1032, -C(O)O-W1033, C(O)NH-W1034, -C(O)NW1035W1036, -O-W1037, -O( 30 W1038-O)rH (i = 1, 2, 3, 4, 5), -O(-W1039-O)rW1040 (i = 1, 2, 3, 4, 5), -OC(O)-W1041, -OC(O)-O-W1042, -OC(O)-NHW1043, -0-C(O)-NW 1044W 1045, -OP(O)(OW 1 046)(OW 1047), OSi(W1048)(W1049)(W1050), -OS(0 2 )-W1051, -NHC(O)- W02007/054556 PCT/EP2006/068322 - 72 W1052, -NW1 053C(0)-W1054, -NH-C(O)-0-W1055,

-NH

C(O)-NH-W1056, -NH-C(O)-NW1057W1058, -NW1059-C(0) O-W1060, -NW1061-C(0)-NH-W1062, -NW1063-C(0) NW1064W1065, -NHS(O 2 )-W1066, -NW1067S(O 2 )-W1068, -S 5 W1069, -S(O)-W1070, -S(0 2 )-W1071, -S(0 2 )NH-W1072, S(O 2 )NW1073W1074, -S(0 2 )O-W1075, P(O)(OW1076)(OW1077), -Si(W1078)(W1079)(W1080)"; where W1029, W1030, W1031, W1032, W1033, W1034, W1035, W1036, W1037, W1038, W1039, W1040, W1041, W1042, W1043, 10 W1044, W1045, W1046, W1047, W1048, W1049, W1050, W1051, W1052, W1053, W1054, W1055, W1056, W1057, W1058, W1059, W1060, W1061, W1062, W1063, W1064, W1065, W1066, W1067, W1068, W1069, W1070, W1071, W1072, W1073, W1074, W1075, W1076, W1077, W1078, W1079, W1080 are each independently 15 selected from the group consisting of: "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W1035, W1036 and/or W1044, W1045 and/or W1057, W1058 and/or W1064, W1065 and/or W1073, W1074, in each case 20 together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 25 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1081, -NW1082W1083, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1084, 30 C(0)O-W1085, -C(O)NH-W1086, -C(O)NW1087W1088, -0 W1089, -O(-W1090-0);-H (j = 1, 2, 3, 4, 5), -O(-W1091-0); W1092 (j = 1, 2, 3, 4, 5), -OC(O)-W1093, -OC(O)-O-W1094, -OC(O)-NHW1095, -O-C(O)-NW1096W1097, OP(O)(OW1098)(OW1099), -OSi(W1100)(W1 101)(W1102), - W02007/054556 -73- PCT/EP2006/068322 OS(0 2 )-W1 103, -NHC(O)-W1 104, -NW1 105C(O)-W1 106, NH-C(O)-O-W1 107, -NH-C(O)-NH-W1 108, -NH-C(O) NW1 109W1 110, -NW1 11 1-C(O)-0-W1 112, -NW1 113 C(O)-NH-W1 114, -NW1 11 5-C(O)-NW1 116W1 117, - 5 NHS(0 2 )-W1118, -NW1119S(O 2 )-W1120, -S-W1121, S(O)-W1 122, -S(0 2 )-W1 123, -S(0 2 )NH-W1 124, S(0 2 )NW1 125W 1126, -S(0 2 )0-W 1127, P(O)(OW1 128)(OW1 129), -Si(W1 130)(W1 131)(W1 132)"; where W1081, W1082, W1083, W1084, W1085, W1086, 10 W10 8 7 , W1088, W1089, W1090, W1091, W1092, W1093, W1094, W1095, W1096, W1097, W1098, W1099, W1 100, W1101, W1102, W1103, W1104, W1105, W1106, W1107, W1108, W1109, W1110, W1111, W1112, W1113, W1114, W1115, W1116, W1117, W1118, W1119, W1120, W1121, 15 W11 22 , W1123, W1124, W1125, W1126, W1127, W1128, W1129, W1130, W1131, W1132 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 20 W1087, W1088 and/or W1096, W1097 and/or W110 9 , W1110 and/or W1116, W1117 and/or W1125, W1126, in each case together, may also form "heterocyclyl"; (j) NZ8Z9 where Z8, Z9 are each independently selected from the group 25 consisting of: (i) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl,

-C(O)

W1 133, -C(O)O-Wi 134, -C(0)-NW1 135W1 136, -S(0 2 )-W1 137, S(0 2 )0-W1 138"; 30 where W1133, W1134, W1135, W1136, W1137, W11 38 are each independently selected from the group consisting of: hydrogen, alkyl,

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, W02007/054556 PCT/EP2006/068322 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W1135, W1136 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 5 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1139, -NW1140W1141,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 10

C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1142, -C(O)O-W1143, C(O)NH-W1144, -C(O)NW1145W1146, -O-W1147, -O( W1148-O)k-H (k = 1, 2, 3, 4, 5), -O(-W1149-O)k-W1150 (k = 1, 2, 3, 4, 5), -OC(O)-W1151, -OC(O)-O-W1152,

-OC(O)

NHW1153, -0-C(O)-NW1154W1155, 15 OP(O)(OW1 156)(OW1 157), -OSi(W1 158)(W1 159)(W1 160), OS(0 2 )-W1 161, -NHC(O)-W1 162, -NW1 163C(O)-Wi 164, -NH C(O)-O-W1 165, -NH-C(O)-NH-W1 166, -NH-C(O) NW1167W1168, -NW1169-C(O)-O-W1170, -NW1171-C(O) NH-W1 172, -NW1 173-C(O)-NW1 174W1 175, -NHS(0 2 )-W1 176, 20 -NW1 177S(0 2 )-W1 178, -S-W1 179, -S(O)-W1 180, -S(0 2

)

W1 181, -S(0 2 )NH-W1 182, -S(0 2 )NW1 183W1 184, -S(0 2

)O

W1185, -P(O)(OW1186)(OW1187), Si(W1 188)(W1 189)(W1190)"; where W1139, W1140, W1141, W1142, W1143, W1144, W1145, 25 W11 4 6 , W11 4 7, W1148, W1149, W1150, W1151, W1152, W1153, W115 4 , W1155, W1156, W1157, W1158, W1159, W1160, W1161, W1162, W1163, W1164, W1165, W1166, W1167, W1168, W1169, W1170, W1171, W1172, W1173, W1174, W1175, W1176, W1177, W1178, W1179, W1180, W1181, W1182, W1183, W1184, W1185, 30 W1186, W1187, W1188, W1189, W1190 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W1145, W1146 and/or W1154, W1155 and/or W1167, W1168 W02007/054556 PCT/EP2006/068322 - 75 and/or W1174, W1175 and/or W1183, W1184, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 5 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1191, -NW1192W1193, 10

NO

2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1194, C(0)O-Wi 195, -C(O)NH-W1 196, -C(O)NW1 197W1 198, -0 W1199, -O(-W1200-O)r-H (I = 1, 2, 3, 4, 5), -O(-W1201-O)r W1202 (1 = 1, 2, 3, 4, 5), -OC(O)-W1203, -OC(O)-O-W1204, 15 -OC(O)-NHW1205, -O-C(O)-NW1206W1207, OP(O)(OW1208)(OW1209), -OSi(W1210)(W1211)(W1212), OS(0 2 )-W1213, -NHC(O)-W1214, -NW1215C(O)-W1216, NH-C(O)-O-W1217, -NH-C(O)-NH-W1218,

-NH-C(O)

NW1219W1220, -NW1221-C(O)-O-W12 22 , -NW1223 20 C(O)-NH-W1224, -NW1225-C(O)-NW1226W1227, NHS(0 2 )-W1228, -NW1229S(0 2 )-W1230, -S-W1231, S(O)-W1232, -S(0 2 )-W1233, -S(0 2 )NH-W1234, S(0 2 )NW1235W1236, -S(0 2 )O-W1237, P(O)(OW1238)(OW1239), -Si(W1240)(W1241)(W1242)"; 25 where W1191, W1192, W1193, W1194, W1195, W1196, W1197, W1198, W1199, W1200, W1201, W1202, W1203, W1204, W1205, W1206, W1207, W1208, W1209, W1210, W121 1, W1212, W1213, W1214, W1215, W1216, W1217, W1218, W1219, W1220, W1221, W1222, W1223, W1224, 30 W1225, W1226, W1227, W1228, W1229, W1230, W 123 1 , W1232, W1233, W1234, W1235, W1236, W1237, W1238, W1239, W1240, W1241, W1242 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, W02007/054556 -76- PCT/EP2006/068322 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W1197, W1198 and/or W1206, W1207 and/or W1219, W1220 and/or W1226, W1227 and/or W1235, W1236, in each case together, may also form "heterocyclyl"; 5 or (D) one of the Z3, Z4 radicals or both Z3, Z4 radicals are each independently selected from the group consisting of: 10 (1) "-NZ10Z11, -OZ12, -SZ13"; where one of the Z1 0, Z1 1 radicals or both Z1 0, Z1 1 radicals and Z1 2, Z1 3 radicals are each independently selected from the group consisting of: (a) "hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl"; 15 with the proviso that both Z1 0, Z1 1 radicals are not simultaneously hydrogen; with the further proviso that the Z12 radical is not hydrogen; with the further proviso that the above substituents of substituent group (a), when they are not hydrogen, are each independently substituted 20 further by at least one substituent selected identically or differently from the group consisting of: (i) "(C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N 3 , -NH cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, 25 -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NQ1Q2, S-cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -0 cycloalkyl, -0-cycloalkylalkyl, -0-arylalkyl, -0-heteroaryl, -0 heteroarylalkyl, -0-heterocyclyl, -0-heterocyclylalkyl, -O(-Q3-O)p 30 H (p = 1, 2, 3, 4, 5), -0(-Q4-O)p-Q5 (p = 1, 2, 3, 4, 5), OP(O)(OQ6)(OQ7), -C(O)O-Q8, -C(O)NH 2 , -C(O)NH-Q9, - W02007/054556 PCT/EP2006/068322 - 77 C(O)NQ1 OQ1 1, -S(0 2 )-Q1 2, -P(O)(OH) 2 , -P(O)(OQ1 3)(OQ1 4), Si(Q15)(Q16)(Q17), -O-Si(Q18)(Q19)(Q20), -O-C(O)-O-Q21, -0 C(O)-NH-Q22, -0-C(O)-NQ23Q24, -NH-C(O)-O-Q25,

-NH-C(O)

NH-Q26, -NH-C(O)-NQ27Q28, -NQ29-C(O)-O-Q30, -NQ31 5 C(O)-NH-Q32, -NQ33-C(O)-NQ34Q35, -NQ36-S(0 2 )-Q37, -NH S(0 2 )-Q38, -O-S(0 2 )-Q39, -NH-C(O)-Q40, -NQ41-C(O)-Q42, C(O)-Q43, -OC(O)-Q44, -S(O)-Q45, -S(0 2 )-NHQ46, -S(0 2

)

NQ47Q48, -S(0 2 )-OQ49"; with the further proviso that "-N(alkyl)2" is further substituted by at 10 least one substituent selected from the following substituent group (ii); where Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8, Q9, Q10, Q11, Q12, Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q20, Q21, Q22, Q23, Q24, Q25, Q26, Q27, Q28, Q29, Q30, Q31, Q32, Q33, Q34, Q35, Q36, Q37, Q38, Q39, Q40, Q41, Q42, Q43, Q44, Q45, Q46, Q47, Q48, Q49 are 15 each independently selected from the group consisting of: "alkyl, (C

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q10, Q11 and/or Q23, Q24 and/or Q27, Q28 and/or Q34, Q35 and/or Q47, Q48, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (a) and/or of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ50, -NQ51Q52,

-NO

2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , SO 3 H, -P(O)(OH) 2 , -C(O)-Q53, -C(O)O-Q54, -C(O)NH-Q55, C(O)NQ56Q57, -O-Q58, -O(-Q59-0),-H (r = 1, 2, 3, 4, 5), -O( 30 Q60-0)-Q61 (r = 1, 2, 3, 4, 5), -OC(O)-Q62, -OC(O)-O-Q63, OC(O)-NHQ64, -O-C(O)-NQ65Q66, -OP(O)(OQ67)(OQ68), OSi(Q69)(Q70)(Q71), -OS(0 2 )-Q72, -NHC(O)-Q73, NQ74C(O)-Q75, -NH-C(O)-O-Q76, -NH-C(O)-NH-Q77,

-NH-

W02007/054556 PCT/EP2006/068322 -78 C(O)-NQ78Q79, -NQ80-C(O)-O-Q81, -NQ82-C(O)-NH-Q83, NQ84-C(O)-NQ85Q86, -NHS(0 2 )-Q87, -NQ88S(0 2 )-Q89, -S Q90, -S(O)-Q91, -S(0 2 )-Q92, -S(0 2 )NH-Q93, -S(0 2 )NQ94Q95, -S(0 2 )O-Q96, -P(O)(OQ97)(OQ98), -Si(Q99)(Q100)(Q101)"; 5 where Q50, Q51, Q52, Q53, Q54, 055, Q56, Q57, Q58, Q59, Q60, Q61, Q62, Q63, Q64, Q65, Q66, Q67, Q68, Q69, Q70, Q71, Q72, Q73, Q74, Q75, Q76, Q77, Q78, Q79, Q80, Q81, Q82, Q83, Q84, Q85, 086, 087, 088, Q89, 090, Q91, Q92, Q93, Q94, Q95, Q96, Q97, Q98, Q99, Q100, Q101 are each independently selected 10 from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q56, Q57 and/or Q65, Q66 and/or Q78, Q79 and/or Q85, Q86 and/or Q94, Q95, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ102, -NQ103Q104, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-l105, -C(O)O-Q106, C(O)NH-Q107, -C(O)NQ108Q109, -O-Q110, -0(-Q 111 25 O),-H (s = 1, 2, 3, 4, 5), -O(-Q112-0),-Q113 (s = 1, 2, 3, 4, 5), -OC(O)-Ql 14, -OC(O)-0-01 15, -OC(O)-NHQ1 16, -0 C(O)-NQ1 17Q118, -OP(O)(OQ1 19)(OQ1 20), OSi(Q121)(Q122)(Q123),

-OS(O

2 )-Q124, -NHC(O)-Q125, NQ126C(O)-Q127, -NH-C(O)-O-Q128,

-NH-C(O)-NH

30 Q129, -NH-C(O)-NQ130Q131, -NQ132-C(O)-0-Q133, NQ134-C(O)-NH-Q135, -NQ136-C(O)-NQ137Q138, NHS(0 2 )-Q139, -NQ140S(O 2 )-Q141, -S-Q142, -S(O)-Q143, -S(0 2 )-Q144, -S(0 2 )NH-Q145, -S(0 2 )NQ146Q147,

-

W02007/054556 PCT/EP2006/068322 S(0 2 )O-Q148, -P(O)(OQ149)(OQ150), Si(Q151)(Q1 52)(Q153)"; where Q102, Q103, Q104, Q105, Q106, Q107, Q108, 0109, Q110, Q111, Q112, Q113, Q114, Q115, 0116, Q117, Q118, 5 Q119, Q120, Q121, Q122, Q123, Q124, Q125, Q126, Q127, Q128, Q129, 0130, Q131, Q132, Q133, Q134, Q135, Q136, Q137, Q138, Q139, Q140, Q141, Q142, Q143, Q144, Q145, Q146, Q147, Q148, Q149, Q150, Q151, Q152, Q153 are each independently selected from the group consisting of: "alkyl, 10

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1 08, Q109 and/or Q117, 0118 and/or Q130, Q131 and/or Q137, Q138 and/or Q146, Q147, in each case together, may also form "heterocyclyl"; 15 (b) "(C 9

-C

30 )alkyl, -C(O)-Q1 54, -C(O)O-Q155, -C(O)-NQ156Q1 57, -S(0 2

)

Q158, -S(0 2 )O-Q159"; where Q154, Q155, Q156, Q157, Q158, Q159 are each independently selected from the group consisting of: "hydrogen, alkyl, (C 9

-C

30 )alkyl, 20 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q156, Q157 together may also form "heterocycly"; where, optionally, the above substituents of substituent group (b) may in turn each independently be substituted by at least one substituent 25 selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ160, -NQ161 Q1 62, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 30

P(O)(OH)

2 , -C(O)-Q163, -C(O)O-Q164, -C(O)NH-Q165, C(O)NQ166Q167, -O-Q168, -0(-Q169-0)t-H (t = 1, 2, 3, 4, 5), -0( Q170-O)t-Q171 (t = 1, 2, 3, 4, 5), -OC(O)-Q172, -OC(O)-O-Q173, OC(O)-NHQ174, -0-C(O)-NQ1 75Q176, -OP(O)(OQ1 77)(OQ178), - W02007/054556 PCT/EP2006/068322 - 80 OSi(Q1 79)(Q1 80)(Q181), -OS(0 2 )-Q1 82, -NHC(O)-Q1 83, NQ1 84C(O)-Q185, -NH-C(O)-O-Q186, -NH-C(O)-NH-Q187, NH-C(O)-NQ1 88Q189, -NQ1 90-C(O)-O-Q1 91, -NQ1 92-C(O)-NH Q193, -NQ1 94-C(O)-NQ1 950196, -NHS(O 2 )-Q1 97, -NQ1 98S(0 2

)

5 Q199, -S-Q200, -S(O)-Q201, -S(0 2 )-Q202, -S(0 2 )NH-Q203, S(0 2 )NQ204Q205, -S(0 2 )O-Q206, -P(O)(OQ207)(OQ208), Si(Q209)(Q21 0)(Q21 1)"; where Q160, Q161, Q162, Q163, 0164, Q165, Q166, Q167, Q168, Q169, Q170, Q171, Q172, Q173, 0174, Q175, Q176, Q177, Q178, 10 Q1 79 , Q180, Q181, Q182, Q183, Q184, Q185, Q186, Q187, Q 188 , Q189, Q190, Q191, Q192, Q193, Q194, Q195, Q196, Q197, Q198, Q199, Q200, Q201, Q202, Q203, 0204, Q205, Q206, Q207, Q208, Q209, Q210, Q21 1 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, 15 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q166, Q167 and/or Q175, Q176 and/or Q188, Q189 and/or Q195, Q196 and/or Q204, Q205, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 20 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ212, -NQ213Q214, -NO 2 , -OH, 25

OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-Q215, -C(O)O-Q216, -C(O)NH Q217, -C(O)NQ218Q219, -O-Q220, -O(-Q221-0),-H (u = 1, 2, 3, 4, 5), -O(-Q222-O),-Q223 (u = 1, 2, 3, 4, 5), -OC(O)-Q224, OC(O)-O-Q225, -OC(O)-NHQ226, -O-C(O)-NQ227Q228, 30 OP(O)(OQ229)(OQ230), -OSi(Q231)(Q232)(Q233), -OS(0 2

)

Q234, -NHC(O)-Q235, -NQ236C(O)-Q237, -NH-C(O)-O-Q238, -NH-C(O)-NH-Q239, -NH-C(O)-NQ240Q241, -NQ242-C(O) 0-Q243, -NQ244-C(O)-NH-Q245, -NQ246-C(O)-NQ247Q248, -NHS(0 2 )-Q249, -NQ250S(0 2 )-Q251, -S-Q252, -S(O)-Q253, - W02007/054556 PCT/EP2006/068322 - 81 S(0 2 )-Q254, -S(0 2 )NH-Q255, -S(O 2 )NQ256Q257, -S(0 2

)O

Q258, -P(O)(OQ259)(OQ260), -Si(Q261)(Q262)(Q263)"; where Q212, Q213, Q214, Q215, Q216, Q217, Q218, Q219, Q220, Q221, Q222, Q223, Q224, Q225, Q226, Q227, Q228, 5 Q229, Q230, Q231, Q232, Q233, Q234, Q235, Q236, Q237, Q238, Q239, Q240, Q241, Q242, Q243, Q244, Q245, Q246, Q247, Q248, Q249, Q250, Q251, Q252, Q253, Q254, Q255, Q256, Q257, Q258, 0259, Q260, Q261, Q262, Q263 are each independently selected from the group consisting of: "alkyl, (Cs 10

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q218, Q219 and/or Q227, Q228 and/or Q240, Q241 and/or Q247, Q248 and/or Q256, Q257, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ264, -NQ265Q266, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q267, -C(O)O-Q268, C(O)NH-Q269, -C(O)NQ270Q271, -O-Q272, -0(-Q273 25 O),-H (v = 1, 2, 3, 4, 5), -O(-Q274-O),-Q275 (v = 1, 2, 3, 4, 5), -OC(O)-Q276, -OC(O)-O-Q277, -OC(O)-NHQ278, -0 C(O)-NQ279Q280, -OP(O)(OQ281)(OQ282), OSi(Q283)(Q284)(Q285), -OS(0 2 )-Q286, -NHC(O)-Q287, NQ288C(O)-Q289, -NH-C(O)-O-Q290,

-NH-C(O)-NH

30 Q291, -NH-C(O)-NQ292Q293, -NQ294-C(O)-O-Q2 9 5, NQ296-C(O)-NH-Q297, -NQ298-C(O)-NQ299Q300, NHS(0 2 )-Q301, -NQ302S(0 2 )-Q303, -S-Q304, -S(O)-Q305, -S(0 2 )-Q306, -S(0 2 )NH-Q307, -S(0 2 )NQ308Q309,

-

W02007/054556 PCT/EP2006/068322 - 82 S(0 2 )O-Q310, -P(O)(OQ31 1)(OQ312), Si(Q313)(Q314)(Q315)"; where Q264, Q265, Q266, Q267, Q268, Q269, Q270, Q271, Q272, Q273, Q274, Q275, Q276, Q277, Q278, Q279, Q280, 5 Q281, Q282, Q283, Q284, Q285, Q286, Q287, Q288, Q289, Q290, Q291, 0292, Q293, Q294, Q295, Q296, Q297, Q298, Q299, Q300, Q301, Q302, Q303, Q304, Q305, Q306, Q307, Q308, Q309, Q310, Q311, Q312, Q313, Q314, Q315 are each independently selected from the group consisting of: "alkyl, 10 (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q270, Q271 and/or Q279, Q280 and/or Q292, Q293 and/or Q299, Q300 and/or Q308, Q309, in each case together, may also form "heterocyclyl"; 15 or one of the Z1 0, Z1 1 radicals or neither of the Z1 0, Z1 1 radicals are each independently selected from the group consisting of: (c) "hydrogen, alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -C(O)-Q316, 20 C(O)O-Q317, -C(O)-NQ318Q319, -S(0 2 )-Q320, -S(0 2 )O-Q321"; where Q316, Q317, Q318, Q319, Q320, Q321 are each independently selected from the group consisting of: "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q318, Q319 together 25 may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (c), when they are not hydrogen, may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 30 (i) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ322, -NQ323Q324, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, - W02007/054556 PCT/EP2006/068322 -83

P(O)(OH)

2 , -C(O)-Q325, -C(O)O-Q326, -C(O)NH-Q327, C(O)NQ328Q329, -O-Q330, -O(-Q331-O)w-H (w = 1, 2, 3, 4, 5), O(-Q332-O).-Q333 (w = 1, 2, 3, 4, 5), -OC(0)-Q334,

-OC(O)-O

Q335, -OC(O)-NHQ336, -0-C(O)-NQ337Q338, 5 OP(O)(OQ339)(OQ340), -OSi(Q341)(Q342)(Q343), -OS(0 2 )-Q344, NHC(O)-Q345, -NQ346C(O)-Q347, -NH-C(O)-O-Q348,

-NH

C(O)-NH-Q349, -NH-C(O)-NQ350Q351, -NQ352-C(O)-0-Q353, NQ354-C(O)-NH-Q355, -NQ356-C(0)-NQ357Q358, -NHS(0 2

)

Q359, -NQ360S(O 2 )-Q361, -S-Q362, -S(O)-Q363,

-S(O

2 )-Q364, 10 S(0 2 )NH-Q365, -S(0 2 )NQ366Q367, -S(0 2 )O-Q368, P(O)(OQ369)(OQ370), -Si(Q371)(Q372)(Q373)"; where Q322, Q323, Q324, Q325, Q326, Q327, Q328, Q329, Q330, Q331, Q332, Q333, Q334, Q335, Q336, Q337, Q338, Q339, Q340, Q341, Q342, Q343, Q344, Q345, Q346, Q347, Q348, Q349, Q350, 15 Q351, Q352, Q353, Q354, Q355, Q356, Q357, Q358, Q359, Q360, Q361, Q362, Q363, Q364, Q365, Q366, Q367, Q368, Q369, Q370, Q371, Q372, Q373 are each independently selected from the group consisting of: "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 20 heteroarylalkyl" and where, alternatively, Q328, Q329 and/or Q337, Q338 and/or Q350, Q351 and/or Q357, Q358 and/or Q366, Q367, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 25 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ374, -NQ375Q376,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 30

-SO

3 H, -P(O)(OH) 2 , -C(O)-Q377, -C(O)O-Q378, -C(O)NH Q379, -C(O)NQ380Q381, -O-Q382, -O(-Q383-0).-H (x = 1, 2, 3, 4, 5), -O(-Q384-0).-Q385 (x = 1, 2, 3, 4, 5), -OC(O)-Q386, OC(O)-O-Q387, -OC(O)-NHQ388, -0-C(O)-NQ389Q390, OP(O)(OQ391)(00392), -OSi(Q393)(Q394)(Q39 5 ), -OS(0 2

)-

W02007/054556 -84- PCT/EP2006/068322 Q396, -NHC(O)-Q397, -NQ398C(O)-Q399, -NH-C(O)-O-Q400, -NH-C(O)-NH-Q401, -NH-C(O)-NQ402Q403, -NQ404-C(O) 0-0405, -NQ406-C(O)-NH-Q407, -NQ408-C(O)-NQ409Q410, -NHS(0 2 )-Q41 1, -NQ412S(0 2 )-Q413, -S-Q414, -S(O)-Q415, 5 S(0 2 )-Q416, -S(0 2 )NH-Q417, -S(0 2 )NQ418Q419, -S(0 2

)O

Q420, -P(O)(OQ421)(OQ422), -Si(Q423)(Q424)(Q 42 5 )"; where Q374, Q375, Q376, Q377, Q378, Q379, Q380, Q381, Q382, Q383, Q384, Q385, Q386, Q387, Q388, Q389, Q390, Q391, Q392, Q393, Q394, Q395, Q396, Q397, Q398, Q399, 10 Q400, Q401, Q402, Q403, Q404, Q405, Q406, Q407, Q408, Q409, Q410, Q411, Q412, Q413, Q414, Q415, Q416, Q417, Q418, Q419, Q420, Q421, Q422, Q423, Q424, Q425 are each independently selected from the group consisting of: "alkyl, (Cq

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 15 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 0380, Q381 and/or Q389, Q390 and/or Q402, Q403 and/or Q409, Q410 and/or Q418, Q419, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) 20 may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 25 C1, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ426, -NQ427Q428, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q429, -C(O)O-Q430, C(O)NH-Q431, -C(O)NQ432Q433, -O-Q434, -O(-Q435 O)y-H (y = 1, 2, 3, 4, 5), -O(-Q436-O)y-Q 4 37 (y = 1, 2, 3, 4, 30 5), -OC(O)-Q438, -OC(O)-O-Q439, -OC(O)-NHQ440, -0 C(O)-NQ441Q442, -OP(O)(OQ443)(OQ444), OSi(Q445)(Q446)(Q 44 7 ), -OS(0 2 )-Q448, -NHC(O)-Q449, NQ450C(O)-Q451, -NH-C(O)-O-Q452,

-NH-C(O)-NH

Q453, -NH-C(O)-NQ454Q455, -NQ456a-C(O)-O-Q456b,

-

W02007/054556 -85- PCT/EP20061068322 NQ456c-C(O)-NH-Q456d, -NQ456e-C(O)-NQ456fQ456g, NHS(0 2 )-Q456h, -NQ456iS(0 2 )-Q456j, -S-Q456k, -S(O) Q4561, -S(0 2 )-Q456m, -S(0 2 )NH-Q456n, S(0 2 )NQ4560Q456p, -S(0 2 )O-Q456q, 5 P(O)(OQ456r)(OQ456s), -Si(Q456t)(Q456u)(Q456v)"; where Q426, Q427, Q428, Q429, Q430, Q431, Q432, Q433, Q434, Q435, Q436, Q437, Q438, Q439, Q440, Q441, 0442, Q443, Q444, Q445, Q446, Q447, Q448, Q449, Q450, Q451, Q452, Q453, Q454, Q455, Q456a, Q456b, Q456c, Q456d, 10 Q456e, Q456f, Q456g, Q456h, Q456i, Q456j, Q456k, Q4561, Q456m, Q456n, Q456o, Q456p, Q456q, Q456r, Q456s, Q456t, Q456u, Q456v are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 15 heteroarylalkyl" and where, alternatively, Q432, Q433 and/or Q441, Q442 and/or Q454, Q455 and/or Q456f, Q456g and/or Q456o, Q456p, in each case together, may also form "heterocyclyl"; 20 and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently selected from the group consisting of: (d) hydrogen; (e) halogen, F, Cl, Br, I; (f) unsubstituted or substituted alkyl or (Cg-C 30 )alkyl, where, optionally, the 25 alkyl or (C 9

-C

30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ457, -NQ458Q459,

-NO

2 , -OH, -OCF 3 , 30 SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Q460, -C(O)O-Q461, -C(O)NH-Q462, C(O)NQ463Q464, -O-Q465, -0(-Q466-0),-H (z = 1, 2, 3, 4, 5), O(-Q467-O)z-Q468 (z = 1, 2, 3, 4, 5), -OC(O)-Q469,

-OC(O)-O-

W02007/054556 PCT/EP2006/068322 - 86 Q470, -OC(O)-NHQ471, -O-C(O)-NQ472Q473, OP(O)(OQ474)(OQ475), -OSi(Q476)(Q477)(Q 4 78 ), -OS(0 2 )-Q479, NHC(O)-Q480, -NQ481C(O)-Q482, -NH-C(O)-O-Q483,

-NH

C(O)-NH-Q484, -NH-C(O)-NQ485Q486, -NQ487-C(O)-O-Q 48 8 , 5 NQ489-C(O)-NH-Q490, -NQ491-C(O)-NQ492Q493, -NHS(0 2

)

Q494, -NQ495S(0 2 )-Q496, -S-Q497, -S(O)-Q498, -S(0 2 )-Q499, S(0 2 )NH-Q500, -S(0 2 )NQ501Q502, -S(0 2 )O-0503, P(O)(OQ504)(OQ505), -Si(Q506)(Q507)(Q508)"; where Q457, Q458, Q459, Q460, Q461, Q462, Q463, Q464, Q465, 10 Q466, Q467, Q468, Q469, Q470, Q471, Q472, Q473, Q474, Q475, Q476, Q477, Q478, Q479, Q480, Q481, Q482, Q483, Q484, Q485, Q486, Q487, Q488, Q489, Q490, Q491, Q492, Q493, Q494, Q495, Q496, Q497, Q498, Q499, Q500, Q501, Q502, Q503, Q504, Q505, Q506, Q507, Q508 are each independently selected from the group 15 consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q463, Q464 and/or Q472, Q473 and/or Q485, Q486 and/or Q492, Q493 and/or Q501, Q502, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 25 Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ509, -NQ51OQ0511,

-NO

2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-0512, -C(0)O-Q513,

-C(O)NH

Q514, -C(O)NQ515Q516, -O-Q517, -O(-Q518-0)a-H (a = 1, 2, 3, 4, 5), -O(-Q519-0),-Q520 (a = 1, 2, 3, 4, 5), -OC(O)-Q521, 30 OC(O)-O-Q522, -OC(O)-NHQ523, -O-C(O)-NQ524Q525, OP(O)(OQ526)(OQ527), -OSi(Q528)(Q529)(Q530), -OS(0 2

)

Q531, -NHC(O)-Q532, -NQ533C(O)-Q53 4 , -NH-C(O)-O-Q535, -NH-C(O)-NH-Q536, -NH-C(O)-NQ537Q538, -NQ539-C(O) 0-0540, -NQ541-C(O)-NH-Q542, -NQ543-C(O)-NQ544Q5 4 5, W02007/054556 -87- PCT/EP2006/068322 -NHS(0 2 )-Q546, -NQ547S(0 2 )-Q548, -S-Q549, -S(O)-Q550, S(0 2 )-Q551, -S(0 2 )NH-Q552, -S(0 2 )NQ553Q554, -S(0 2

)O

Q555, -P(O)(OQ556)(OQ557), -Si(Q558)(Q559)(Q560)"; where Q509, Q510, Q511, Q512, Q513, Q514, Q515, 0516, 5 Q517, Q518, Q519, Q520, Q521, Q522, Q523, Q524, Q525, Q526, Q527, Q528, Q529, Q530, Q531, Q532, Q533, Q534, Q535, Q536, Q537, Q538, Q539, Q540, Q541, 0542, Q543, Q544, Q545, Q546, 0547, Q548, Q549, Q550, Q551, Q552, 0553, Q554, Q555, Q556, Q557, Q558, Q559, Q560 are each 10 independently selected from the group consisting of: "alkyl, (Ce

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q515, 0516 and/or Q524, Q525 and/or Q537, Q538 and/or Q544, Q545 and/or Q553, Q554, in each case together, may also form 15 "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 20 (iii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHQ561, -NQ562Q563,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q564, -C(0)0-0565, 25 C(O)NH-Q566, -C(O)NQ567Q568, -O-Q569, -O(-Q570 O)b-H (b = 1, 2, 3, 4, 5), -0(-Q571-O)b-Q 572 (b = 1, 2, 3, 4, 5), -OC(O)-Q573, -OC(O)-O-Q574, -OC(O)-NHQ575, -0 C(O)-NQ576Q577, -OP(O)(OQ578)(OQ579), OSi(Q580)(0581)(Q58 2 ), -OS(0 2 )-Q583, -NHC(O)-Q584, 30 NQ585C(O)-Q586, -NH-C(O)-O-Q587,

-NH-C(O)-NH

0588, -NH-C(O)-NQ589Q590, -NQ591-C(O)-O-Q592, NQ593-C(O)-NH-Q594, -NQ595-C(O)-NQ596Q597, NHS(0 2 )-Q598, -NQ599S(0 2 )-Q600, -S-Q601, -S(O)-Q602, -S(0 2 )-Q603, -S(0 2 )NH-Q604, -S(0 2 )NQ605Q606, - W02007/054556 -88- PCT/EP2006/06832 2 S(0 2 )O-Q607, -P(O)(OQ608)(OQ609), Si(Q61 0)(Q61 1)(Q612)"; where Q561, Q562, 0563, Q564, Q565, Q566, Q567, Q568, Q569, Q570, Q571, Q572, Q573, Q574, Q575, Q576, Q577, 5 Q578, Q579, Q580, Q581, Q582, 0583, 0584, Q585, Q586, Q587, Q588, Q589, Q590, Q591, Q592, Q593, Q594, Q595, Q596, Q597, Q598, Q599, Q600, Q601, Q602, Q603, Q604, Q605, Q606, 0607, Q608, Q609, 0610, Q611, Q612 are each independently selected from the group consisting of: "alkyl, 10

(C

9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q567, Q568 and/or Q576, Q577 and/or Q589, Q590 and/or Q596, Q597 and/or Q605, Q606, in each case together, may also form "heterocyclyl"; 15 (g) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ613, -NQ614Q615,

-NO

2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Q616, -C(O)O-Q617, -C(O)NH-Q618, C(O)NQ619Q620, -O-Q621, -O(-Q622-O)c-H (c = 1, 2, 3, 4, 5), 25 O(-Q623-O)c-Q624 (c = 1, 2, 3, 4, 5), -OC(O)-Q625, -OC(O)-O Q626, -OC(O)-NHQ627, -0-C(O)-NQ628Q629, OP(O)(OQ630)(OQ631), -OSi(Q632)(Q633)(Q63 4 ), -OS(0 2 )-0635, NHC(O)-Q636, -NQ637C(O)-Q638, -NH-C(O)-0-Q639,

-NH

C(O)-NH-Q640, -NH-C(O)-NQ641Q642, -NQ643-C(O)-0-Q6 4 4 , 30 NQ645-C(O)-NH-Q646, -NQ647-C(O)-NQ648Q649, -NHS(0 2

)

Q650, -NQ651 S(0 2 )-Q652, -S-Q653, -S(O)-Q654, -S(0 2 )-Q655, S(0 2 )NH-Q656, -S(0 2 )NQ657Q658, -S(0 2 )O-Q659, P(O)(OQ660)(OQ661), -Si(Q662)(Q663)(Q664)"; W020071054556 -89- PCT/EP2006/068322 where Q613, Q614, Q615, Q616, Q617, 0618, Q619, Q620, Q621, 0622, Q623, Q624, Q625, Q626, Q627, Q628, Q629, Q630, Q631, Q632, Q633, Q634, Q635, Q636, Q637, Q638, Q639, Q640, Q641, Q642, Q643, Q644, Q645, Q646, Q647, Q648, Q649, Q650, Q651, 5 Q652, Q653, Q654, Q655, Q656, Q657, Q658, Q659, Q660, 0661, Q662, Q663, Q664 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q619, Q620 and/or Q628, 10 0629 and/or 0641, Q642 and/or 0648, Q649 and/or 0657, Q658, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (ii) "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ665, -NQ666Q667, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-0668, -C(O)O-Q669,

-C(O)NH

20 Q670, -C(O)NQ671 Q672, -O-Q673, -0(-Q674-0)-H (d = 1, 2, 3, 4, 5), -O(-Q675-O)d-Q 676 (d = 1, 2, 3, 4, 5), -OC(O)-Q677, OC(O)-O-Q678, -OC(O)-NHQ679, -O-C(o)-NQ680Q681, OP(O)(OQ682)(OQ683), -OSi(Q684)(Q685)(Q686), -OS(0 2

)

0687, -NHC(O)-Q688, -NQ689C(O)-Q690, -NH-C(O)-O-Q691, 25 -NH-C(O)-NH-Q692, -NH-C(O)-NQ693Q694, -NQ695-C(O) O-Q696, -NQ697-C(O)-NH-Q698, -NQ699-C(O)-NQ700Q701, -NHS(0 2 )-Q702, -NQ703S(0 2 )-Q704, -S-Q705, -S(O)-Q706, S(0 2 )-Q707, -S(0 2 )NH-Q708, -S(0 2 )NQ709Q710, -S(0 2 )0 Q711, -P(O)(OQ712)(OQ713), -Si(Q714)(Q715)(Q716)"; 30 where Q665, Q666, Q667, Q668, Q669, 0670, 0671, Q672, Q673, Q674, Q675, Q676, Q677, 0678, Q679, Q680, Q681, 0682, Q683, Q684, Q685, 0686, Q687, Q688, Q689, Q690, Q691, Q692, Q693, Q694, Q695, Q696, Q697, Q698, Q699, Q700, Q701, Q702, Q703, Q704, Q705, Q706, Q707, Q708, W02007/054556 PCT/EP2006/068322 Q709, Q710, Q711, Q712, Q713, Q714, Q715, Q716 are each independently selected from the group consisting of: "alkyl, (C

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 5 Q671, Q672 and/or Q680, Q681 and/or Q693, Q694 and/or Q700, 0701 and/or Q709, Q710, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 10 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ717, -NQ718Q719, -NO 2 , 15 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q720, -C(O)O-Q721, C(O)NH-Q722, -C(O)NQ723Q724, -O-Q725, -O(-Q726 O)-H (e = 1, 2, 3, 4, 5), -O(-Q727-0)e-Q728 (e = 1, 2, 3, 4, 5), -OC(O)-Q729, -OC(O)-O-Q730, -OC(O)-NHQ731, -0 20 C(O)-NQ732Q733, -OP(O)(OQ734)(OQ735), OSi(Q736)(Q737)(Q73 8 ), -OS(0 2 )-Q739, -NHC(O)-Q740, NQ741 C(O)-Q742, -N H-C(O)-O-Q743, -N H-C(O)-N H Q744, -NH-C(O)-NQ745Q746, -NQ747-C(O)-O-Q7 48 , NQ749-C(O)-NH-Q750, -NQ751-C(O)-NQ752Q753, 25 NHS(0 2 )-Q754, -NQ755S(0 2 )-Q756, -S-Q757, -S(O)-Q758, -S(0 2 )-Q759, -S(0 2 )NH-Q760, -S(0 2 )NQ761Q762, S(0 2 )O-Q763, -P(O)(OQ764)(OQ765), Si(Q766)(Q767)(Q768)"; where Q717, Q718, Q719, Q720, Q721, Q722, Q723, Q724, 30 Q725, Q726, Q727, Q728, Q729, Q730, Q731, Q732, Q733, Q734, Q735, Q736, Q737, Q738, Q739, Q740, Q741, Q742, Q743, Q744, Q745, Q746, Q747, Q748, Q749, Q750, Q751, Q752, Q753, Q754, Q755, Q756, Q757, Q758, Q759, Q760, Q761, Q762, Q763, Q764, Q765, Q766, Q767, Q768 are each W02007/054556 PCT/EP2006/068322 independently selected from the group consisting of: "alkyl,

(C-C

3 o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q723, Q724 and/or Q732, Q733 and/or 5 Q745, Q746 and/or Q752, Q753 and/or Q761, Q762, in each case together, may also form "heterocyclyl"; (h) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl radical may be substituted by at least one substituent selected identically 10 or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ769, -NQ770Q771,

-NO

2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 15

P(O)(OH)

2 , -C(O)-Q772, -C(0)O-Q773, -C(O)NH-Q774, C(O)NQ775Q776, -O-Q777, -O(-Q778-O)r-H (f = 1, 2, 3, 4, 5), -O( Q779-O)r-Q780 (f = 1, 2, 3, 4, 5), -OC(O)-0781, -OC(O)-O-Q782, OC(O)-NHQ783, -O-C(O)-NQ784Q785, -OP(O)(OQ786)(OQ787), OSi(Q788)(Q789)(Q790), -OS(0 2 )-Q791, -NHC(O)-Q792, 20 NQ793C(O)-Q794, -NH-C(O)-O-Q795, -NH-C(O)-NH-Q796, NH-C(O)-NQ797Q798, -NQ799-C(O)-O-Q800, -NQ801-C(O)-NH Q802, -NQ803-C(O)-NQ804Q805, -NHS(0 2 )-Q806, -N0807S(0 2

)

Q808, -S-Q809, -S(O)-Q810, -S(0 2 )-Q811, -S(0 2 )NH-Q812, S(0 2 )NQ813Q814, -S(0 2 )O-Q815, -P(O)(OQ816)(OQ817), 25 Si(Q818)(Q819)(Q820)"; where Q769, Q770, Q771, Q772, Q773, Q774, Q775, Q776, Q777, Q778, Q779, Q780, Q781, Q782, Q783, Q784, Q785, Q786, Q787, Q788, Q789, Q790, Q791, Q792, Q793, Q794, Q795, Q796, Q797, Q798, Q799, Q800, 0801, Q802, Q803, Q804, Q805, Q806, Q807, 30 Q808, Q809, Q810, Q811, Q812, Q813, Q814, Q815, Q816, Q817, Q818, Q819, Q820 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, W02007/054556 -92- PCT/EP2006/068322 heteroarylalkyl" and where, alternatively, Q775, Q776 and/or Q784, Q785 and/or Q797, Q798 and/or Q804, 0805 and/or Q813, Q814, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 5 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ821, -NQ822Q823,

-NO

2 , -OH, 10

OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-Q824, -C(O)O-Q825,

-C(O)NH

Q826, -C(O)NQ827Q828, -O-Q829, -O(-Q830-0)g-H (g = 1, 2, 3, 4, 5), -0(-0831-O)g-0832 (g = 1, 2, 3, 4, 5), -OC(O)-Q833, OC(O)-O-Q834, -OC(O)-NHQ835, -O-C(O)-NQ836Q837, 15 OP(O)(OQ838)(OQ839), -OSi(Q840)(Q841)(Q842), -OS(0 2

)

Q843, -NHC(O)-Q844, -NQ845C(O)-Q846, -NH-C(O)-O-Q847, -NH-C(O)-NH-Q848, -NH-C(O)-NQ849Q850, -NQ851-C(O) O-Q852, -NQ853-C(O)-NH-Q854, -NQ855-C(O)-NQ856Q857, -NHS(0 2 )-Q858, -NQ859S(0 2 )-Q860, -S-Q861, -S(O)-Q862, 20 S(0 2 )-Q863, -S(0 2 )NH-Q864, -S(0 2 )NQ865Q866, -S(0 2

)O

Q867, -P(O)(OQ868)(OQ869), -Si(Q870)(Q871)(Q872)"; where 0821, Q822, Q823, Q824, Q825, Q826, Q827, Q828, Q829, Q830, Q831, Q832, Q833, Q834, Q835, Q836, Q837, Q838, Q839, Q840, Q841, Q842, Q843, Q844, Q845, Q846, 25 Q847, Q848, Q849, Q850, Q851, Q852, Q853, Q854, 0855, Q856, Q857, Q858, Q859, Q860, Q861, Q862, Q863, Q864, Q865, Q866, Q867, Q868, 0869, Q870, Q871, Q872 are each independently selected from the group consisting of: "alkyl, (Cs

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 30 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q827, 0828 and/or Q836, Q837 and/or 0849, Q850 and/or Q856, Q857 and/or 0865, Q866, in each case together, may also form "heterocyclyl"; W02007/054556 -93- PCT/EP2006/068322 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, l, CN, CF 3 , N 3 , NH 2 , -NHQ873, -NQ8740875,

-NO

2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-0876, -C(O)O-Q877, 10 C(O)NH-Q878, -C(O)NQ879Q880, -O-Q881, -O(-Q882 O)h-H (h = 1, 2, 3, 4, 5), -0(-Q883-O)h-Q884 (h = 1, 2, 3, 4, 5), -OC(O)-Q885, -OC(O)-O-Q886, -OC(O)-NHQ887, -0 C(O)-NQ888Q889, -OP(O)(OQ890)(OQ891), OSi(Q892)(Q893)(Q894), -OS(0 2 )-Q895, -NHC(O)-Q896, 15 NQ897C(O)-Q898, -NH-C(O)-O-Q899,

-NH-C(O)-NH

Q900, -NH-C(O)-NQ901Q902, -NQ903-C(O)-O-Q904, NQ905-C(O)-NH-Q906, -NQ907-C(O)-NQ908Q90 9 , NHS(0 2 )-Q91 0, -NQ91 1 S(O 2 )-Q912, -S-Q913, -S(O)-Q914, -S(0 2 )-Q915, -S(0 2 )NH-Q916, -S(0 2 )NQ917Q918, 20 S(0 2 )O-Q919, -P(O)(OQ920)(OQ921), Si(Q922)(Q923)(Q924)"; where Q873, Q874, Q875, Q876, Q877, Q878, Q879, 0880, Q881, Q882, Q883, Q884, Q885, 0886, 0887, Q888, Q889, Q890, Q891, Q892, Q893, Q894, Q895, Q896, Q897, Q898, 25 Q899, Q900, Q901, Q902, Q903, Q904, Q905, Q906, Q907, Q908, Q909, Q910, Q911, Q912, Q913, Q914, Q915, Q916, Q917, Q918, Q919, Q920, Q921, 0922, Q923, Q924 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q879, Q880 and/or Q888, Q889 and/or Q901, Q902 and/or Q908, Q909 and/or Q917, Q918, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 94 (j) OZ6 where Z6 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 5 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ925, -NQ926Q927, -NO 2 , -OH, 10

OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH)2, -C(O)-Q928, -C(O)O-Q929,

-C(O)NH

Q930, -C(O)NQ931Q932, -O-Q933, -0(-Q934-O)r-H (i = 1, 2, 3, 4, 5), -O(-Q935-O)-Q936 (i = 1, 2, 3, 4, 5), -OC(O)-Q937, OC(O)-O-Q938, -OC(O)-NHQ939, -0-C(O)-NQ940Q941, 15 OP(O)(OQ942)(OQ943), -OSi(Q944)(Q945)(Q946), -OS(0 2

)

Q947, -NHC(O)-Q948, -NQ949C(O)-Q950, -NH-C(O)-O-Q951, -NH-C(O)-NH-Q952, -NH-C(O)-NQ953Q954, -NQ955-C(O) 0-0956, -NQ957-C(O)-NH-Q958, -NQ959-C(O)-NQ960Q961, -NHS(0 2 )-Q962, -NQ963S(0 2 )-Q964, -S-Q965, -S(O)-Q966, 20 S(0 2 )-Q967, -S(0 2 )NH-Q968, -S(0 2 )NQ969Q970, -S(0 2 )0 Q971, -P(O)(OQ972)(OQ973), -Si(Q974)(Q975)(Q976)"; where Q925, Q926, Q927, Q928, Q929, Q930, Q931, Q932, Q933, 0934, Q935, Q936, Q937, Q938, Q939, Q940, Q941, Q942, 0943, Q944, Q945, Q946, Q947, Q948, Q949, Q950, 25 Q951, Q952, Q953, Q954, Q955, Q956, Q957, 0958, Q959, Q960, 0961, Q962, Q963, Q964, Q965, Q966, Q967, Q968, Q969, Q970, Q971, Q972, Q973, Q974, Q975, Q976 are each independently selected from the group consisting of: "alkyl, (Cs

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 30 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q931, Q932 and/or Q940, 0941 and/or Q953, Q954 and/or Q960, Q961 and/or Q969, Q970, in each case together, may also form "heterocyclyl"; W02007/054556 -95- PCT/EP20061068322 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ977, -NQ978Q979, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-0980, -C(O)O-Q981, 10 C(O)NH-Q982, -C(O)NQ983Q984, -0-0985, -O(-Q 986

-O)

H (j = 1, 2, 3, 4, 5), -O(-Q987-O)j-Q988 (j = 1, 2, 3, 4, 5), OC(O)-Q989, -OC(O)-O-Q990, -OC(O)-NHQ991, -0-C(O) NQ992Q993, -OP(O)(OQ994)(OQ995), OSi(Q996)(Q997)(Q998), -OS(0 2 )-Q999, -NHC(O)-Q1000, 15 NQ1001C(O)-Q1002, -NH-C(O)-O-Q1003,

-NH-C(O)-NH

Q1004, -NH-C(O)-NQ1005Q1006, -NQ1007-C(O)-O Q1008, -NQ1 009-C(O)-NH-Q1010, -NQ1011-C(O) NQ1012Q1013, -NHS(0 2 )-Q1014, -NQ1015S(O 2 )-Q1016, S-Q1017, -S(O)-Q1018, -S(0 2 )-Q1019, -S(0 2 )NH-Q1020, 20 S(0 2 )NQ1021Q1022, -S(0 2 )O-Q1023, P(O)(OQ1024)(OQ1025), -Si(Q1026)(Q1027)(Q1028)"; where Q977, Q978, Q979, Q980, Q981, Q982, Q983, Q984, Q985, Q986, Q987, Q988, Q989, Q990, Q991, Q992, Q993, Q994, Q995, Q996, Q997, Q998, Q999, Q1000, Q1001, 25 Q1002, Q1003, Q1004, Q1005, Q1006, Q1007, Q1008, Q1009, Q1010, Q1011, Q1012, Q1013, Q1014, Q1015, Q1016, Q1017, Q1018, Q1019, Q1020, Q1021, Q1022, Q1023, Q1024, Q1025, Q1026, Q1027, Q1028 are each independently selected from the group consisting of: "alkyl, 30

(C-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q983, Q984 and/or Q992, Q993 and/or Q1005, Q1006 and/or Q1012, Q1013 and/or Q1021, Q1022, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 96 (k) SZ7 where Z7 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 5 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 10 Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ1029, -NQ1030Q1031, -NO 2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1032, -C(O)O-Q1033, C(O)NH-Q1034, -C(O)NQ1 035Q1036, -O-Q1037, -O(-Q1038 O)k-H (k = 1, 2, 3, 4, 5), -O(-Q1039-O)k-Q1040 (k = 1, 2, 3, 4, 5), 15 -OC(O)-Q1041, -OC(O)-O-Q1042, -OC(O)-NHQ1043, -0 C(O)-NQ1 044Q1045, -OP(O)(OQ1 046)(OQ1047), OSi(Q1048)(Q1049)(Q1050),

-OS(O

2 )-Q1051, -NHC(O)-Q1052, -NQ1053C(O)-Q1054, -NH-C(O)-0-Q1055,

-NH-C(O)-NH

Q1056, -NH-C(O)-NQ1057Q1058, -NQ1059-C(O)-O-Q1060, 20 NQ1061-C(O)-NH-Q1062, -NQ1063-C(O)-NQ1064Q1065, NHS(0 2 )-Q1066, -NQ1067S(0 2 )-Q1068, -S-Q1069, -S(O) Q1070, -S(0 2 )-Q1071, -S(0 2 )NH-Q1072, -S(0 2 )NQ1073Q1074, -S(0 2 )O-Q1075, -P(O)(OQ1 076)(OQ1077), Si(Q1 078)(Q1 079)(Q1080)"; 25 where Q1029, Q1030, Q1031, Q1032, Q1033, Q1034, Q1035, Q1036, Q1037, Q1038, Q1039, Q1040, Q1041, Q1042, Q1043, Q1044, Q1045, Q1046, Q1047, Q1048, Q1049, Q1050, Q1051, Q1052, Q1053, Q1054, Q1055, Q1056, Q1057, Q1058, Q1059, Q1060, Q1061, Q1062, Q1063, Q1064, Q1065, Q1066, Q1067, 30 Q1068, Q1069, Q1070, Q1071, Q1072, Q1073, Q1074, Q1075, Q1076, Q1077, Q1078, Q1079, Q1080 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, W02007/054556 PCT/EP2006/068322 - 97 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1035, Q1036 and/or Q1044, Q1045 and/or Q1057, Q1058 and/or Q1064, Q1065 and/or Q1073, Q1074, in each case together, may also form "heterocyclyl"; 5 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ1081, -NQ1082Q1083, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1084, C(O)O-Q1085, -C(O)NH-Q1086, -C(O)NQ1087Q1088, -0 15 Q1089, -O(-Q1090-0)r-H (I = 1, 2, 3, 4, 5), -O(-QlO 9 l-O)r Q1092 (1 = 1, 2, 3, 4, 5), -OC(O)-Q1093, -OC(O)-O-Q1094, OC(O)-NHQ1095, -O-C(O)-NQ1096Q1097, OP(O)(OQ1098)(OQ1099), -OSi(Q1100)(Q1101)(Q1102), OS(0 2 )-Q1 103, -NHC(O)-Q1 104, -NQ1 105C(O)-Q1 106, 20 NH-C(O)-O-Q1 107, -NH-C(O)-NH-Q1 108, -NH-C(O) NQ1 109Q1 110, -NQ1 11 1-C(O)-O-Q1 112, -NQ1 113-C(O) NH-Q1 114, -NQ1 11 5-C(O)-NQ1 116Q1 117, -NHS(O2) Q1 118, -NQ1 11 9S(O2)-Q1 120, -S-Q1 121, -S(0)-Q1 122, S(0 2 )-Q1 123, -S(0 2 )NH-Q1 124, -S(0 2 )NQ1 125Q1126, 25 S(0 2 )O-Q1 127, -P(O)(OQ1 128)(OQ1 129), Si(Q1130)(Q1 131)(Q1132)"; where Q1081, Q1082, Q1083, Q1084, Q1085, Q1086, Q1087, Q1088, Q1089, Q1090, Q1091, Q1092, Q1093, Q1094, Q1095, Q1096, Q1097,Q1098,Q1099, Q1100, Q1101, 30 Q1102, Q1103, Q1104, Q1105, Q1106, Q1107, Q110 8 , Q1109, 01110, 01111, Q1112, Q1113, Q1114, Q1115, Q1116, Q1117, Q1118, Q1119, Q1120, Q1121, Q1122, Q1123, Q1124, Q1125, Q1126, Q1127, Q1128, 01129, Q1 130, Q1131, Q1132 are each independently selected from W02007/054556 -98- PCT/EP2006/068322 the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q 1087, Q1088 and/or Q1096, Q1097 and/or Q1 109, Q1 110 and/or 5 Q1116, Q1117 and/or Q1125, Q1126, in each case together, may also form "heterocyclyl"; (I) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: 10 (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) Q1133, -C(O)O-Q1134, -C(O)-NQ1135Q1136, -S(0 2 )-Q1137, S(0 2 )O-Q1 138"; where Q1133, Q1134, Q1135, Q1136, Q1137, Q1138 are each 15 independently selected from the group consisting of: hydrogen, alkyl,

(C-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1 135, Q1 136 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 20 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ1 139i -NQ1 140Q1 141, -NO 2 , -OH, 25

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1142, -C(O)O-Q1 143, C(O)NH-Q1144, -C(O)NQ1145Q1146, -O-Q1147, -O(-Q1148 O)m-H (m = 1, 2, 3, 4, 5), -0(-Q1149-0)m-Ql150 (m = 1, 2, 3, 4, 5), -OC(O)-Q1 151, -OC(O)-O-Q1 152, -OC(O)-NHQ1 153, -0 30 C(O)-NQ1 154Q1 155, -OP(O)(OQ1 156)(OQ1 157), OSi(Q1 158)(Q1 159)(Q1 160), -OS(0 2 )-Q1 161, -NHC(O)-Q1 162, -NQ1 163C(O)-Q1 164, -NH-C(O)-O-Q1 165, -NH-C(O)-NH Q1 166, -NH-C(O)-NQ1 167Q1 168, -NQ1 169-C(O)-O-Q1 170, - W02007/054556 PCT/EP2006/068322 -99 NQ1 171-C(O)-NH-Q1 172, -NQ1 173-C(O)-NQ1 174Q1 175, NHS(0 2 )-Q1 176, -NQ 177S(0 2 )-Q1 178, -S-Q1 179, -S(O) Q1180, -S(0 2 )-Q1 181, -S(0 2 )NH-Q1 182, -S(0 2 )NQ1 183Q1184, -S(02)0-Q1185, -P(O)(OQ1 186)(OQ1 187), 5 Si(Q1 188)(Q1 189)(Q1 190)"; where Q1139, Q1140, Q1141, Q1142, Q1143, Q1144, Q1145, Q1146, Q1147, Q1148, Q1149, Q1150, Q1151, Q1152, Q1153, Q1154, 01155, Q1156, Q1157, Q1158, Q1159, Q1160, Q1161, Q1162, Q1163, Q1164, Q1165, Q1166, Q1167, Q1168, Q1169, 10 Q1170, Q1171, Q1172, Q1173, Q1174, Q1175, Q1176, Q11 77 , Q1178, Q1179, Q1180, Q1181, Q1182, Q1183, Q1184, Q1185, Q1186, Q1187, Q1188, Q1189, Q1190 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 15 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 01145, Q1146 and/or Q1154, Q1155 and/or Q1167, Q1168 and/or Q1174, Q1175 and/or Q1 183, Q1184, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) 20 may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 25 Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ1191, -NQ1192Q1193, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1 194, C(O)O-Q1195, -C(O)NH-Q1196, -C(O)NQ1197Q1198, -0 Q1199, -O(-Q1200-O)n-H (n = 1, 2, 3, 4, 5), -O(-Q1201 30 O)n-Q1202 (n = 1, 2, 3, 4, 5), -OC(O)-Q1203, -OC(O)-O Q1204, -OC(O)-NHQ1205, -O-C(O)-NQ1206Q1207, OP(O)(OQ1208)(OQ1209), -OSi(Q1210)(Q1211)(Q1212), OS(02)-Q1213, -NHC(O)-Q1214, -NQ1215C(O)-Q1216, NH-C(O)-O-Q1217, -NH-C(O)-NH-Q1218,

-NH-C(O)-

W02007/054556 PCT/EP2006/068322 - 100 NQ1219Q1220, -NQ1221-C(O)-O-Q1222, -NQ1223-C(O) NH-Q1224, -NQ1225-C(O)-NQ1226Q1227, -NHS(0 2

)

Q1228, -NQ1229S(0 2 )-Q1230, -S-Q1231, -S(O)-Q1232, S(0 2 )-Q1233, -S(0 2 )NH-Q1234, -S(0 2 )NQ1235Q1236, 5 S(0 2 )O-Q1237, -P(O)(OQ1238)(OQ1239), Si(Q1240)(Q1241)(Q1242)"; where Q1191, Q1192, Q1193, Q1194, Q1195, Q1196, Q1197, Q1198, Q1199, Q1200, Q1201, Q1202, Q1203, Q1204, 01205, Q1206, Q1207, Q1208, Q1209, Q1210, Q1211, 10 Q1212, Q1213, Q1214, Q1215, Q1216, Q1217, Q1218, Q1219, Q1220, Q1221, Q1222, Q1223, Q1224, Q1225, Q1226, Q1227, Q1228, Q1229, Q1230, Q1231, Q1232, Q1233, Q1234, Q1235, Q1236, Q1237, Q1238, Q1239, Q1240, Q1241, 01242 are each independently selected from 15 the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1197, Q1198 and/or Q1206, Q1207 and/or Q1219, Q1220 and/or Q1226, Q1227 and/or Q1235, Q1236, in each case together, 20 may also form "heterocyclyl"; and Z1, Z2 radicals are each independently selected from the group consisting of: 25 "hydrogen, NZ14Z15"; with the proviso that when Z1 = H, Z2 = NZ14Z15, and when Z1 = NZ14Z15, Z2 = H; where Z14, Z15 are each independently selected from the group consisting of: (a) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(Y1)NZ1 6Z1 7, C(=NZ18)-Z19, -C(Y2)NZ20-Y3-Z21"; W02007/054556 PCT/EP2006/068322 -101 with the proviso that Z1 4, Z1 5 are not simultaneously hydrogen or "alkyl, (C

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; with the further proviso that when one of the Z1 4, Z1 5 radicals is hydrogen or 5 "alkyl, (CO-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl", the other Z14, Z15 radical in each case is "-C(Y1)NZ16Z17", "-C(=NZ18)-Z19" or "-C(Y2)NZ20-Y3-Z21"; where Y1, Y2, Y3 are each independently selected from the group consisting of "0, S, =NH, =NZ22"; 10 where Z16, Z17, Z18, Z19, Z20, Z21, Z22 are each independently selected from the group consisting of: (1) hydrogen (2) "alkyl, (Cg-C3 0 )alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl"; 15 where the above substituents of substitution group (a) and/or substitution group (2) may optionally each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, 20 CN, CF 3 , N 3 , NH 2 , -NHU1, -NU2U3, -NO 2 , -OH, -OCF 3 , -SH, -0

SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U4, -C(0)O-U5, -C(O)NH-U6, -C(O)NU7U8, -O-U9, -O( U10-0)r-H (r = 1, 2, 3, 4, 5), -O(-U1 1-0)r-U12 (r = 1, 2, 3, 4, 5), OC(O)-U13, -OC(O)-O-U14, -OC(O)-NHU15, -O-C(O)-NU16U17, 25 -OP(O)(OU18)(OU19), -OSi(U20)(U21)(U22), -OS(O 2 )-U23, NHC(O)-U24, -NU25C(O)-U26, -NH-C(O)-O-U27, -NH-C(O)-NH U28, -NH-C(O)-NU29U30, -NU31-C(O)-O-U32, -NU33-C(O)-NH U34, -NU35-C(O)-NU36U37, -NHS(0 2 )-U38, -NU39S(0 2 )-U40, S-U41, -S(O)-U42, -S(0 2 )-U43, -S(0 2 )NH-U44, -S(0 2 )NU45U46, 30 S(0 2 )O-U47, -P(O)(OU48)(OU49), -Si(U50)(U51)(U52)"; where U1, U2, U3, U4, U5, U6, U7, U8, U9, U10, U11, U12, U13, U14, U15, U16, U17, U18, U19, U20, U21, U22, U23, U24, U25, U26, U27, W02007/054556 PCT/EP2006/068322 -102 U28, U29, U30, U31, U32, U33, U34, U35, U36, U37, U38, U39, U40, U41, U42, U43, U44, U45, U46, U47, U48, U49, U50, U51, U52 are each independently selected from the group consisting of: "alkyl, (C

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 5 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U7, U8 and/or U16, U17 and/or U29, U30 and/or U36, U37 and/or U45, U46, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 10 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHU53, -NU54U55, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 15 SO 3 H, -P(O)(OH) 2 , -C(O)-U56, -C(O)O-U57, -C(O)NH-U58, C(O)NU59U60, -O-U61, -O(-U62-0),-H (r = 1, 2, 3, 4, 5), -O( U63-0),-U64 (r = 1, 2, 3, 4, 5), -OC(O)-U65, -OC(O)-O-U66, OC(O)-NHU67, -O-C(O)-NU68U69, -OP(O)(OU70)(OU71), OSi(U72)(U73)(U74), -OS(0 2 )-U75, -NHC(O)-U76, -NU77C(O) 20 U78, -NH-C(O)-O-U79, -NH-C(O)-NH-U80, -NH-C(O) NU81U82, -NU83-C(O)-O-U84, -NU85-C(O)-NH-U86, -NU87 C(O)-NU88U89, -NHS(0 2 )-U90, -NU91S(0 2 )-U92, -S-U93, S(O)-U94, -S(0 2 )-U95, -S(0 2 )NH-U96, -S(0 2 )NU97U98, S(0 2 )O-U99, -P(O)(OU100)(OU101), -Si(U102)(U103)(U104)"; 25 where U53, U54, U55, U56, U57, U58, U59, U60, U61, U62, U63, U64, U65, U66, U67, U68, U69, U70, U71, U72, U73, U74, U75, U76, U77, U78, U79, U80, U81, U82, U83, U84, U85, U86, U87, U88, U89, U90, U91, U92, U93, U94, U95, U96, U97, U98, U99, U100, U101, U 102, U103, U104 are each independently selected 30 from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U59, U60 and/or U68, U69 and/or U81, U82 and/or U88, U89 and/or U97, U98, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -103 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU105, -NU106U107, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U108, -C(O)O-U109, 10 C(O)NH-U110, -C(O)NU111U112, -O-U113, -O(-U114-0)s H (s = 1, 2, 3, 4, 5), -0(-U115-0)-U116 (s = 1, 2, 3, 4, 5), OC(O)-U1 17, -OC(O)-O-U118, -OC(O)-NHU1 19, -0-C(O) NU120U121, -OP(O)(OU122)(OU123), OSi(U124)(U125)(U126), -OS(O 2 )-U127, -NHC(O)-U128, 15 NU129C(O)-U130, -NH-C(O)-O-U131, -NH-C(O)-NH U132, -NH-C(O)-NU1 33U134, -NU1 35-C(O)-O-U136, NU137-C(O)-NH-U138, -NU139-C(O)-NU14OU141, NHS(0 2 )-U142, -NU143S(O 2 )-U144, -S-U145, -S(O)-U146, -S(0 2 )-U147, -S(0 2 )NH-U148, -S(0 2 )NU149U150, -S(0 2 )0 20 U151, -P(O)(OU152)(OU153), -Si(U154)(U155)(U156)"; where U105, U106, U107, U108, U109, U110, U111, U112, U113, U114, U115, U116, U117, U118, U119, U120, U121, U122, U123, U124, U125, U126, U127, U128, U129, U130, U131, U132, U133, U134, U135, U136, U137, U138, U139, 25 U140, U141, U142, U143, U144, U145, U146, U147, U148, U149, U150, U151, U152, U153, U154, U155, U156 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 30 where, alternatively, U111, U112 and/or U120, U121 and/or U133, U134 and/or U140, U141 and/or U149, U150, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -104 (3) -C(O)-Z23, where Z23 is independently selected from the group consisting of: (a) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 5 where the above substituents of substitution group (a) may optionally each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 10 Br, I, CN, CF 3 , N 3 , NH 2 , -NHU157, -NU158U159, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-U160, -C(0)O-U161, -C(O)NH U162, -C(O)NU163U164, -O-U165, -O(-U166-O)t-H (t = 1, 2, 3, 4, 5), -O(-U167-O)-U168 (t = 1, 2, 3, 4, 5), -OC(O)-U169, 15 OC(O)-O-U170, -OC(O)-NHU171, -0-C(O)-NU1 72U173, OP(O)(OU174)(OU175), -OSi(U176)(U177)(U178), -OS(02) U179, -NHC(O)-U180, -NU181C(O)-U182, -NH-C(O)-O-U183, -NH-C(O)-NH-U184, -NH-C(O)-NU185U186, -NU187-C(O) O-U188, -NU189-C(O)-NH-U190, -NU191-C(O)-NU192U193, 20 -NHS(0 2 )-U194, -NU195S(O 2 )-U196, -S-U197, -S(O)-U198, S(0 2 )-U 199, -S(O 2 )NH-U200, -S(O 2 )NU201 U202, -S(02)0 U203, -P(O)(OU204)(OU205), -Si(U206)(U207)(U208)"; where U157, U158, U159, U160, U161, U162, U163, U164, U165, U166, U167, U168, U169, U170, U171, U172, U173, U174, U175, 25 U176, U177, U178, U179, U180, U181, U182, U183, U184, U185, U186, U187, U188, U189, U190, U191, U192, U193, U194, U195, U196, U197, U198, U199, U200, U201, U202, U203, U204, U205, U206, U207, U208 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, 30 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U163, U164 and/or U172, U173 and/or U185, U186 and/or U192, U193 and/or U201, U202, in each case together, may also form "heterocyclyl"; W020071054556 PCT/EP2006/068322 -105 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU209, -NU21OU211, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U212, -C(O)O-U213, 10 C(O)NH-U214, -C(O)NU215U216, -O-U217, -O(-U218-O)U H (u = 1, 2, 3, 4, 5), -O(-U219-O),-U220 (u = 1, 2, 3, 4, 5), OC(O)-U221, -OC(O)-O-U222, -OC(O)-NHU223, -0-C(O) NU224U225, -OP(O)(OU226)(OU227), OSi(U228)(U229)(U230), -OS(0 2 )-U231, -NHC(O)-U232, 15 NU233C(O)-U234, -NH-C(O)-0-U235, -NH-C(O)-NH U236, -NH-C(O)-NU237U238, -NU239-C(O)-O-U240, NU241-C(O)-NH-U242, -NU243-C(O)-NU244U245, NHS(0 2 )-U246, -NU247S(0 2 )-U248, -S-U249, -S(O)-U250, -S(0 2 )-U251, -S(0 2 )NH-U252, -S(0 2 )NU253U254, -S(0 2

)O

20 U255, -P(O)(OU256)(OU257), -Si(U258)(U259)(U260)"; where U209, U210, U211, U212, U213, U214, U215, U216, U217, U218, U219, U220, U221, U222, U223, U224, U225, U226, U227, U228, U229, U230, U231, U232, U233, U234, U235, U236, U237, U238, U239, U240, U241, U242, U243, 25 U244, U245, U246, U247, U248, U249, U250, U251, U252, U253, U254, U255, U256, U257, U258, U259, U260 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 30 where, alternatively, U215, U216 and/or U224, U225 and/or U237, U238 and/or U244, U245 and/or U253, U254, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least W02007/054556 PCT/EP2006/068322 - 106 one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, 5 F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU261, -NU262U263, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U264, C(O)O-U265, -C(O)NH-U266, -C(O)NU267U268, -0 U269, -0(-U270-0)v-H (v = 1, 2, 3, 4, 5), -0(-U271-O)v 10 U272 (v = 1, 2, 3, 4, 5), -OC(O)-U273, -OC(O)-O-U274, -OC(O)-NHU275, -O-C(O)-NU276U277, OP(O)(OU278)(OU279), -OSi(U280)(U281)(U282), OS(0 2 )-U283, -NHC(O)-U284, -NU285C(O)-U286, -NH C(O)-O-U287, -NH-C(O)-NH-U288, -NH-C(O) 15 NU289U290, -NU291-C(O)-O-U292, -NU293-C(O)-NH U294, -NU295-C(O)-NU296U297, -NHS(0 2 )-U298, NU299S(0 2 )-U300, -S-U301, -S(O)-U302, -S(0 2 )-U303, -S(0 2 )NH-U304, -S(O 2 )NU305U306, -S(0 2 )O-U307, P(O)(OU308)(OU309), -Si(U31 0)(U31 1)(U312)"; 20 where U261, U262, U263, U264, U265, U266, U267, U268, U269, U270, U271, U272, U273, U274, U275, U276, U277, U278, U279, U280, U281, U282, U283, U284, U285, U286, U287, U288, U289, U290, U291, U292, U293, U294, U295, U296, U297, U298, U299, U300, U301, U302, U303, U304, 25 U305, U306, U307, U308, U309, U310, U311, U312 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U267, U268 and/or U276, U277 30 and/or U289, U290 and/or U296, U297 and/or U305, U306, in each case together, may also form "heterocyclyl"; (4) Z16, Z17 may independently optionally also form "heterocyclyl" together; W02007/054556 PCT/EP20061068322 -107 (5) "-C(O)-C(O)-U313, -S(0 2 )-NU314U315"; where U313, U314, U315 are each independently selected from the group consisting of: 5 (1) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHU316, NU317U318, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U319, 10 C(O)O-U320, -C(O)NH-U321, -C(O)NU322U323, -O-U324, -O( U325-O).-H (w = 1, 2, 3, 4, 5), -O(-U326-O).-U327 (w = 1, 2, 3, 4, 5), -OC(O)-U328, -OC(O)-O-U329, -OC(O)-NHU330, -0 C(O)-NU331 U332, -OP(O)(OU333)(OU334), OSi(U335)(U336)(U337), -OS(0 2 )-U338, -NHC(O)-U339, 15 NU340C(O)-U341, -NH-C(O)-O-U342, -NH-C(O)-NH-U343, NH-C(O)-NU344U345, -NU346-C(O)-O-U347, -NU348-C(O) NH-U349, -NU350-C(O)-NU351U352, -NHS(0 2 )-U353, NU354S(0 2 )-U355, -S-U356, -S(O)-U357, -S(0 2 )-U358, S(0 2 )NH-U359, -S(0 2 )NU360U361, -S(0 2 )O-U362, 20 P(O)(OU363)(OU364), -Si(U365)(U366)(U367)"; where U316, U317, U318, U319, U320, U321, U322, U323, U324, U325, U326, U327, U328, U329, U330, U331, U332, U333, U334, U335, U336, U337, U338, U339, U340, U341, U342, U343, U344, U345, U346, U347, U348, U349, U350, U351, U352, U353, U354, 25 U355, U356, U357, U358, U359, U360, U361, U362, U363, U364, U365, U366, U367 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U322, U323 and/or U331, 30 U332 and/or U344, U345 and/or U351, U352 and/or U360, U361, in each case together, may also form "heterocycly"; where, optionally, the above substituents of substitution group (1) may each independently be further substituted by at least one W02007/054556 PCT/EP2006/068322 -108 substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 5 Br, I, CN, CF 3 , N 3 , NH 2 , -NHU368, -NU369U370, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U371, -C(O)O-U372, C(O)NH-U373, -C(O)NU374U375, -O-U376, -O(-U377-0)x-H (x = 1, 2, 3, 4, 5), -O(-U378-0),-U379 (x = 1, 2, 3, 4, 5), 10 OC(O)-U380, -OC(O)-O-U381, -OC(O)-NHU382, -0-C(O) NU383U384, -OP(O)(OU385)(OU386), OSi(U387)(U388)(U389), -OS(0 2 )-U390, -NHC(O)-U391, NU392C(O)-U393, -NH-C(O)-O-U394, -NH-C(O)-NH-U395, -NH-C(O)-NU396U397, -NU398-C(O)-0-U399, -NU400 15 C(O)-NH-U401, -NU402-C(O)-NU403U404, -NHS(0 2 )-U405, -NU406S(0 2 )-U407, -S-U408, -S(O)-U409, -S(0 2 )-U410, S(0 2 )NH-U41 1, -S(0 2 )NU412U413, -S(0 2 )O-U414, P(O)(OU415)(OU416), -Si(U417)(U418)(U419)"; where U368, U369, U370, U371, U372, U373, U374, U375, 20 U376, U377, U378, U379, U380, U381, U382, U383, U384, U385, U386, U387, U388, U389, U390, U391, U392, U393, U394, U395, U396, U397, U398, U399, U400, U401, U402, U403, U404, U405, U406, U407, U408, U409, U410, U411, U412, U413, U414, U415, U416, U417, U418, U419 are each 25 independently selected from the group consisting of: "alkyl, (CO

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U374, U375 and/or U383, U384 and/or U396, U397 and/or U403, U404 and/or U412, U413, in each 30 case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 - 109 (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU420, -NU421U422, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, 5 COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U423, C(O)O-U424, -C(O)NH-U425, -C(O)NU426U427, -0 U428, -O(-U429-0)y-H (y = 1, 2, 3, 4, 5), -O(-U430-O)y U431 (y = 1, 2, 3, 4, 5), -OC(O)-U432, -OC(O)-O-U433, OC(O)-NHU434, -O-C(O)-NU435U436, 10 OP(O)(OU437)(OU438), -OSi(U439)(U440)(U441), OS(0 2 )-U442, -NHC(O)-U443, -NU444C(O)-U445, -NH C(O)-0-U446, -NH-C(O)-NH-U447, -NH-C(O) NU448U449, -NU450-C(O)-O-U451, -NU452-C(O)-NH U453, -NU454-C(O)-NU455U456, -NHS(0 2 )-U457, 15 NU458S(0 2 )-U459, -S-U460, -S(O)-U461, -S(0 2 )-U462, S(0 2 )NH-U463, -S(0 2 )NU464U465, -S(0 2 )O-U466, P(O)(OU467)(OU468), -Si(U469)(U470)(U471)"; where U420, U421, U422, U423, U424, U425, U426, U427, U428, U429, U430, U431, U432, U433, U434, U435, U436, 20 U437, U438, U439, U440, U441, U442, U443, U444, U445, U446, U447, U448, U449, U450, U451, U452, U453, U454, U455, U456, U457, U458, U459, U460, U461, U462, U463, U464, U465, U466, U467, U468, U469, U470, U471 are each independently selected from the group consisting of: "alkyl, 25

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U426, U427 and/or U435, U436 and/or U448, U449 and/or U455, U456 and/or U464, U465, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 -110 (iii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU472, -NU473U474, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, 5 OP(O)(OH) 2 , -CHO, -COOH., -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-U475, -C(O)O-U476, -C(O)NH U477, -C(O)NU478U479, -O-U480, -O(-U481-O),-H (z = 1, 2, 3, 4, 5), -O(-U482-O),-U483 (z = 1, 2, 3, 4, 5), OC(O)-U484, -OC(O)-O-U485, -OC(O)-NHU486, -0 10 C(O)-NU487U488, -OP(O)(OU489)(OU490), OSi(U491)(U492)(U493), -OS(0 2 )-U494, -NHC(O) U495, -NU496C(O)-U497, -NH-C(O)-O-U498, -NH C(O)-NH-U499, -NH-C(O)-NU50OU501, -NU502 C(O)-O-U503, -NU504-C(O)-NH-U505, -NU506 15 C(O)-NU507U508, -NHS(0 2 )-U509, -NU51 OS(0 2

)

U511, -S-U512, -S(O)-U513, -S(O 2 )-U514, -S(0 2

)NH

U515, -S(0 2 )NU516U517, -S(0 2 )O-U518, P(O)(OU519)(OU520), -Si(U521)(U522)(U523)"; where U472, U473, U474, U475, U476, U477, U478, 20 U479, U480, U481, U482, U483, U484, U485, U486, U487, U488, U489, U490, U491, U492, U493, U494, U495, U496, U497, U498, U499, U500, U501, U502, U503, U504, U505, U506, U507, U508, U509, U510, U511, U512, U513, U514, U515, U516, U517, U518, 25 U519, U520, U521, U522, U523 are each independently selected from the group consisting of: "alkyl, (CO

C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U478, U479 30 and/or U487, U488 and/or U500, U501 and/or U507, U508 and/or U516, U517, in each case together, may also form "heterocyclyl"; and where, alternatively, U314, U315 together may also form "heterocyclyl"; W02007/054556 PCT/EP20061068322 - 111 and the Z5 radical is independently selected from the group consisting of: 5 (i) "hydrogen, alkyl, (C 9

-C

CF

3 , N 3 , NH 2 , -NHA1, -NA2A3, -NO 2 , -OH, -OCF 3 , -SH, -0-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-A4, C(0)O-A5, -C(O)NH-A6, -C(O)NA7A8, -O-A9, -0(-A1 0-O)r-H (r = 1, 2, 3, 10 4, 5), -O(-Al1-)r-A12 (r = 1, 2, 3, 4, 5), -OC(O)-Al 3, -OC(O)-O-A14, OC(O)-NHAl 5, -O-C(O)-NAl 6A1 7, -OP(O)(OA1 8)(OAl 9), OSi(A20)(A21)(A22), -OS(O 2 )-A23, -NHC(O)-A24, -NA25C(O)-A26, -NH C(O)-0-A27, -NH-C(O)-NH-A28, -NH-C(O)-NA29A30, -NA31-C(O)-O A32, -NA33-C(O)-NH-A34, -NA35-C(O)-NA36A37, -NHS(0 2 )-A38, 15 NA39S(0 2 )-A40, -S-A41, -S(O)-A42, -S(0 2 )-A43, -S(0 2 )NH-A44, S(0 2 )NA45A46, -S(0 2 )O-A47, -P(O)(OA48)(OA49), -Si(A50)(A51)(A52)"; where Al, A2, A3, A4, A5, A6, A7, A8, A9, Al0, Al1, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, 20 A44, A45, A46, A47, A48, A49, A50, A51, A52 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, A7, A8 and/or Al 6, Al 7 and/or A29, A30 and/or A36, A37 and/or A45, A46, in each case together, may also form 25 "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHA53, -NA54A55, -NO 2 , -OH, -OCF 3 , -SH, -0

SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-A56, -C(O)O-A57, -C(O)NH-A58, -C(O)NA59A60, -O-A61, -O(- W02007/054556 PCT/EP2006/068322 -112 A62-0),-H (s = 1, 2, 3, 4, 5), -O(-A63-O)-A64 (t = 1, 2, 3, 4, 5), OC(O)-A65, -OC(O)-O-A66, -OC(O)-NHA67, -O-C(O)-NA68A69, OP(O)(OA70)(OA71), -OSi(A72)(A73)(A74), -OS(0 2 )-A75, -NHC(O) A76, -NA77C(O)-A78, -NH-C(O)-O-A79, -NH-C(O)-NH-A80, -NH 5 C(O)-NA81A82, -NA83-C(O)-O-A84, -NA85-C(O)-NH-A86, -NA87 C(O)-NA88A89, -NHS(0 2 )-A90, -NA91S(0 2 )-A92, -S-A93, -S(O)-A94, -S(0 2 )-A95, -S(0 2 )NH-A96, -S(O 2 )NA97A98, -S(0 2 )O-A99, P(O)(OA1 00)(OA1 01), -Si(A1 02)(A1 03)(A1 04)"; where A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63, A64, 10 A65, A66, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, A79, A80, A81, A82, A83, A84, A85, A86, A87, A88, A89, A90, A91, A92, A93, A94, A95, A96, A97, A98, A99, A100, Al01, A102, A103, A104 are each independently selected from the group consisting of: "alkyl, (Ce

C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 15 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, A59, A60 and/or A68, A69 and/or A81, A82 and/or A88, A89 and/or A97, A98, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent 20 selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHA105, -NA106A107, -NO 2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 25 P(O)(OH) 2 , -C(O)-Al 08, -C(0)O-Al 09, -C(O)NH-A1 10, C(O)NA111A12, -O-A113, -O(-A114-O)t-H (t = 1, 2, 3, 4, 5), -O( Al115-0)t-Al 16 (t = 1, 2, 3, 4, 5), -OC(O)-A1 17, -OC(O)-O-A1 18, OC(0)-NHA1 19, -0-C(O)-NA1 20A1 21, -OP(O)(OA1 22)(OA1 23), OSi(A124)(A125)(A126), -OS(O 2 )-A127, -NHC(O)-Al28, 30 NA1 29C(O)-Al 30, -NH-C(O)-O-A1 31, -NH-C(O)-NH-Al 32, -NH C(O)-NA1 33A1 34, -NA1 35-C(O)-O-Al 36, -NA1 37-C(O)-N H A138, -NA139-C(O)-NA14OA141, -NHS(0 2 )-Al42, -NA143S(0 2

)

A144, -S-A145, -S(O)-A146, -S(0 2 )-A147, -S(0 2 )NH-A148, W02007/054556 PCT/EP2006/068322 -113 S(0 2 )NA1 49A1 50, -S(0 2 )O-A1 51, -P(O)(OA1 52)(OA1 53), Si(A1 54)(A1 55)(A1 56)"; where A105, A106, A107, A108, A109, A110, A111, A112, A113, A114, A115, A116, A117, A118, A119, A120, A121, A122, A123, 5 A124, A125, A126, A127, A128, A129, A130, A131, A132, A133, A134, A135, A136, A137, A138, A139, A140, A141, A142, A143, A144, A145, A146, A147, A148, A149, A150, A151, A152, A153, A154, A155, A156 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, 10 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Al 11, Al 12 and/or Al 20, A121 and/or A133, A134 and/or A140, A141 and/or A149, A150, in each case together, may also form "heterocyclyl"; 15 or (E) one of the Z1, Z2 radicals or both Z1, Z2 radicals are each independently selected from the group consisting of: (a) -NZ24Z25; 20 with the proviso that one of the Z24, Z25 radicals or both Z24, Z25 radicals are each independently selected from the group consisting of: (1) "-C(O)-C(O)-T1, -S(0 2 )-NT2T3"; where T1, T2, T3 are each independently selected from the group consisting of: 25 (1) "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT4, -NT5T6, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T7, -C(O)O-T8, -C(O)NH 30 T9, -C(O)NT1OT11, -O-T12, -O(-T13-O)p-H (p = 1, 2, 3, 4, 5), O(-Tl4-O)p-T15 (p = 1, 2, 3, 4, 5), -OC(O)-T16, -OC(O)-O-T17, OC(O)-NHT18, -0-C(O)-NT19T20, -OP(O)(OT21)(OT22), - W02007/054556 PCTIEP2006/068322 -114 OSi(T23)(T24)(T25), -OS(0 2 )-T26, -NHC(O)-T27, -NT28C(O) T29, -NH-C(O)-O-T30, -NH-C(O)-NH-T31, -NH-C(O)-NT32T33, -NT34-C(O)-O-T35, -NT36-C(O)-NH-T37, -NT38-C(O) NT39T40, -NHS(O 2 )-T41, -NT42S(0 2 )-T43, -S-T44, -S(O)-T45, 5 S(0 2 )-T46, -S(0 2 )NH-T47, -S(0 2 )NT48T49, -S(0 2 )O-T50, P(O)(OT51)(OT52), -Si(T53)(T54)(T55)"; where T4, T5, T6, T7, T8, T9, T10, T11, T12, T13, T14, T15, T16, T17, T18, T19, T20, T21, T22, T23, T24, T25, T26, T27, T28, T29, T30, T31, T32, T33, T34, T35, T36, T37, T38, T39, T40, T41, T42, 10 T43, T44, T45, T46, T47, T48, T49, T50, T51, T52, T53, T54, T55 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T10, T11 and/or T19, T20 and/or T32, T33 15 and/or T39, T40 and/or T48, T49, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substitution group (I) may each independently be further substituted by at least one substituent selected identically or differently from the group 20 consisting of: (i) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT56, -NT57T58, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 25 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T59, -C(O)O-T60, C(O)NH-T61, -C(O)NT62T63, -0-T64, -0(-T65-0)r-H (r = 1, 2, 3, 4, 5), -0(-T66-0),-T67 (r = 1, 2, 3, 4, 5), -OC(O)-T68, OC(O)-O-T69, -OC(O)-NHT70, -O-C(O)-NT71T72, OP(O)(OT73)(OT74), -OSi(T75)(T76)(T77), -OS(0 2 )-T78, 30 NHC(O)-T79, -NT80C(O)-T81, -NH-C(O)-O-T82, -NH-C(O) NH-T83, -NH-C(O)-NT84T85, -NT86-C(O)-O-T87, -NT88 C(O)-NH-T89, -NT90-C(O)-NT91T92, -NHS(0 2 )-T93, NT94S(0 2 )-T95, -S-T96, -S(O)-T97, -S(O 2 )-T98, -S(0 2

)NH-

W02007/054556 PCT/EP2006/068322 -115 T99, -S(0 2 )NT10OT101, -S(0 2 )O-T102, -P(O)(OT103)(OT104), -Si(T1 05)(T1 06)(T107)"; where T56, T57, T58, T59, T60, T61, T62, T63, T64, T65, T66, T67, T68, T69, T70, T71, T72, T73, T74, T75, T76, T77, T78, 5 T79, T80, T81, T82, T83, T84, T85, T86, T87, T88, T89, T90, T91, T92, T93, T94, T95, T96,T97, T98, T99, T100,T1Ol, T102, T103, T104, T105, T106, T107 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 10 heteroaryl, heteroarylalkyl" and where, alternatively, T62, T63 and/or T71, T72 and/or T84, T85 and/or T91, T92 and/or T1 00, T101, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one 15 substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT108, -NT109T110, -NO 2 , 20 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Ti 11, -C(O)O-Ti 12, -C(O)NH-TI13, -C(O)NT114TI15, -O-T116, -O(-T117 O),-H (s = 1, 2, 3, 4, 5), -O(-T 11 8-0),-T 119 (s = 1, 2, 3, 4, 5), -OC(O)-T120, -OC(O)-O-T121, -OC(O)-NHT122, -0 25 C(O)-NT1 23T1 24, -OP(O)(OT1 25)(OT1 26), OSi(T127)(T128)(T129), -OS(O 2 )-T130, -NHC(O)-T131, NT132C(O)-T133, -NH-C(O)-O-T1 34, -NH-C(O)-NH T135, -NH-C(O)-NT136T137, -NT138-C(O)-0-T139, NT140-C(O)-NH-T141, -NT142-C(O)-NT143T144, 30 NHS(0 2 )-T145, -NT146S(O 2 )-T147, -S-T148, -S(O)-T149, -S(0 2 )-T150, -S(0 2 )NH-T151, -S(0 2 )NT152T153, S(0 2 )O-T154, -P(O)(OT155)(OT156), Si(T1 57)(T1 58)(T1 59)"; W02007/054556 PCT/EP2006/068322 -116 where T108, T109, T110, T111, T112, T113, T114, T115, T116, T117, T118,T119,T120, T121, T122, T123, T124, T125, T126, T127, T128, T129, T13O, T131, T132, T133, T134, T135, T136, T137, T138, T139, T140, T141, T142, 5 T143,T144, T145, T146, T147, T148,T149,T150,T151, T152, T153, T154, T155, T156, T157, T158, T159 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" 10 and where, alternatively, T1 14, T1 15 and/or T1 23, T1 24 and/or T1 36, T137 and/or T143, T144 and/or T152, T153, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least 15 one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT160, 20 -NT161T162, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T163, -C(O)O-T164, -C(O)NH-T165, -C(O)NT1 66T1 67, -O-T168, -O(-T169-O)t-H (t = 1, 2, 3, 4, 5), -O(-T170-O)r-T171 (t = 1, 2, 3, 4, 5), -OC(O) 25 T172, -OC(O)-0-T173, -OC(O)-NHT174, -0-C(0) NT175T176, -OP(O)(OT177)(OT178), OSi(T179)(T180)(T181), -OS(O 2 )-T182, -NHC(O)-T183, -NT184C(O)-T185, -NH-C(O)-O-T186, -NH-C(O) NH-T1 87, -NH-C(O)-NT1 88T1 89, -NT1 90-C(O)-O 30 T191, -NT192-C(0)-NH-T193, -NT194-C(O) NT195T196, -NHS(0 2 )-T197, -NT198S(0 2 )-T199, -S T200, -S(0)-T201, -S(0 2 )-T202, -S(0 2 )NH-T203, S(0 2 )NT204T205, -S(0 2 )O-T206, P(O)(OT207)(OT208), -Si(T209)(T210)(T21 1)"; W02007/054556 PCT/EP2006/068322 -117 where T160, T161, T162, T163, T164, T165, T166, T167, T168, T169, T170, T171, T172, T173, T174, T175, T176, T177, T178, T179, T180, T181, T182, T183, T184, T185, T186, T187, T188, T189, T190, T191, T192, T193, T194, 5 T195, T196, T197, T198, T199, T200, T201, T202, T203, T204, T205, T206, T207, T208, T209, T210, T211 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 10 heteroarylalkyl" and where, alternatively, T166, T167 and/or T175, T176 and/or T188, T189 and/or T195, T196 and/or T204, T205, in each case together, may also form "heterocyclyl"; where, alternatively, T2, T3 together may also form "heterocyclyl"; 15 and one of the Z24, Z25 radicals or neither of the Z24, Z25 radicals is also independently selected from the group consisting of: (2) "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 20 where, optionally, the above substituents of substitution group (2) may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 25 1, CN, CF 3 , N 3 , NH 2 , -NHT212, -NT213T214, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T215, -C(O)O-T216, -C(O)NH-T217, C(O)NT218T219, -O-T220, -O(-T221-O)u-H (u = 1, 2, 3, 4, 5), O(-T222-O),-T223 (u = 1, 2, 3, 4, 5), -OC(O)-T224, -OC(O)-O 30 T225, -OC(O)-NHT226, -O-C(O)-NT227T228, OP(O)(OT229)(OT230), -OSi(T231)(T232)(T233), -OS(0 2 )-T234, NHC(O)-T235, -NT236C(O)-T237, -NH-C(O)-O-T238, -NH C(O)-NH-T239, -NH-C(O)-NT240T241, -NT242-C(O)-O-T243, - W020071054556 PCT/EP2006/068322 -118 NT244-C(O)-NH-T245, -NT246-C(O)-NT247T248, -NHS(0 2

)

T249, -NT250S(0 2 )-T251, -S-T252, -S(O)-T253, -S(0 2 )-T254, S(0 2 )NH-T255, -S(0 2 )NT256T257, -S(0 2 )O-T258, P(O)(OT259)(OT260), -Si(T261)(T262)(T263)"; 5 where T212, T213, T214, T215, T216, T217, T218, T219, T220, T221,T222, T223,T224, T225,T226,T227,T228, T229,T230, T231, T232, T233, T234, T235, T236, T237, T238, T239, T240, T241,T242, T234,T244, T245,T246,T247,T248, T249,T250, T251,T252, T253, T254, T255,T256,T257,T258, T259,T260, 10 T261, T262, T263 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T218, T219 and/or T227, T228 and/or T240, T241 and/or T247, T248 and/or T256, T257, in 15 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT264, -NT265T266, -NO 2 , -OH, OCF 3 , -SH, -0-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T267, -C(O)O-T268, C(O)NH-T269, -C(O)NT270T271, -O-T272, -0(-T273-O)v-H 25 (v = 1, 2, 3, 4, 5), -O(-T274-0),-T275 (v = 1, 2, 3, 4, 5), OC(O)-T276, -OC(O)-O-T277, -OC(O)-NHT278, -0-C(0) NT279T280, -OP(O)(OT281)(OT282), -OSi(T283)(T284)(T285), -OS(0 2 )-T286, -NHC(O)-T287, -NT288C(O)-T289,

-NH

C(O)-O-T290, -NH-C(O)-NH-T291, -NH-C(O)-NT292T293, 30 NT294-C(O)-O-T295, -NT296-C(O)-NH-T297, -NT298 C(O)-NT299T300, -NHS(0 2 )-T301, -NT302S(0 2 )-T303, -S T304, -S(O)-T305, -S(0 2 )-T306, -S(0 2 )NH-T307, S(0 2 )NT308T309, -S(0 2 )O-T310, -P(O)(OT311)(OT312), Si(T313)(T314)(T315)"; W020071054556 PCT/EP2006/068322 -119 where T264, T265, T266, T267, T268, T269, T270, T271, T272, T273, T274,T275, T276,T277,T278,T279, T280, T281, T282, T283, T284, T285, T286, T287,T288,T289, T290, T291, T292, T293, T294, T295, T296, T297, T298, T299, T300, T301, T302, 5 T303, T304, T305, T306, T307, T308, T309, T310, T311, T312, T313, T314, T315 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T270, T271 10 and/or T279, T280 and/or T292, T293 and/or T299, T300 and/or T308, T309, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 15 consisting of: (iii) "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT316, -NT317T318, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 20

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T319, -C(O)O-T320, -C(O)NH-T321, -C(O)NT322T323, -O-T324, -O(-T325 O),-H (w = 1, 2, 3, 4, 5), -O(-T326-O).-T327 (w = 1, 2, 3, 4, 5), -OC(O)-T328, -OC(O)-O-T329, -OC(O)-NHT330, O-C(O)-NT331T332, -OP(O)(OT333)(OT334), 25 OSi(T335)(T336)(T337), -OS(O 2 )-T338, -NHC(O)-T339, NT340C(O)-T341, -NH-C(O)-O-T342, -NH-C(O)-NH T343, -NH-C(O)-NT344T345, -NT346-C(O)-O-T347, NT348-C(O)-NH-T349, -NT350-C(O)-NT351T352, NHS(0 2 )-T353, -NT354S(0 2 )-T355, -S-T356, -S(O)-T357, 30 -S(0 2 )-T358, -S(0 2 )NH-T359, -S(0 2 )NT360T361, S(0 2 )O-T362, -P(O)(OT363)(OT364), Si(T365)(T366)(T367)"; where T316, T317, T318, T319, T320, T321, T322, T323, T324, T325, T326, T327,T328,T329, T330,T331, T332, W02007/054556 PCT/EP2006/068322 - 120 T333,T334, T335,T336, T337,T338,T339,T340,T341, T342, T343, T344, T345, T346, T347, T348, T349, T350, T351, T352, T353, T354, T355, T356, T357, T358, T359, T360, T361, T362, T363, T364, T365, T366, T367 are each 5 independently selected from the group consisting of: "alkyl,

(C

9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T322, T323 and/or T331, T332 and/or T344, T345 and/or T351, T352 and/or T360, T361, in 10 each case together, may also form "heterocyclyl"; (b) -NZ26Z27 where one of the Z26, Z27 radicals or both Z26, Z27 radicals are each independently selected from the group consisting of: (1) "-C(Y4)NZ28Z29, -C(=NZ30)-Z31"; 15 where Y4 is independently selected from the group consisting of "0, S, =NH, =NZ32"; with the proviso that at least one of the Z28, Z29 radicals and at least one of the Z30, Z31 radicals is independently selected from the group consisting of: 20 (1) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C(O)-aikyl, -C(O) aryl, -C(O)-heteroaryl"; with the further proviso that the above substituents of substituent group (1) are each independently substituted further by at least one substituent selected identically or differently from the group 25 consisting of: (i) "(C 9

-C

30 )alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, N 3 , -NT368T369, -NHC(0)-cycloalkylalkyl, NHC(O)-heterocyclylalkyl, -NT370C(O)-T371, -NH-C(O)-0 T372, -NH-C(O)-NH-T373, -NH-C(O)-NT374T375, -NT376 30 C(O)-O-T377, -NT378-C(O)-NH-T379, -NT380-C(O) NT381T382, -NHS(0 2 )-cycloalkylalkyl, -NHS(0 2

)

heterocyclylalkyl, -NT383S(0 2 )-T384, -0-T385, -O(-T386- W02007/054556 PCT/EP2006/068322 -121 O),-T387 (x = 1, 2, 3, 4, 5), -O(-T388-0),-H (x = 1, 2, 3, 4, 5), -OC(O)-cycloalkylalkyl, -OC(O)-heterocyclylalkyl, -OC(O)-O T389, -OC(O)-NHT390, -O-C(O)-NT391T392, -OS(O 2

)

cycloalkylalkyl, -OS(0 2 )-heterocyclyalkyl, 5 OP(O)(OT393)(OT394), -OSi(T395)(T396)(T397), -CHO, C(O)-cycloalkyl, -C(O)-heterocyclyl, -C(O)-cycloalkylalkyl, C(O)-heterocyclylalkyl, -C(O)-arylalkyl, -C(O)-heteroarylalkyl, -S- cycloalkylalkyl, -S-heterocyclylalkyl, -S-arylalkyl, -S heteroarylalkyl, -S(O)-cycloalkyl, -S(O)-heterocyclyl, -S(O) 10 heteroaryl, -S(O)-cycloalkylalkyl, -S(O)-heterocyclylalkyl, S(O)-arylalkyl, -S(O)-heteroarylalkyl, -S(0 2 )-cycloalkyl, S(0 2 )-heterocyclyl, -S(0 2 )-heteroaryl, -S(0 2 )-cycloalkylalkyl, S(0 2 )-heterocyclylalkyl, -S(0 2 )-arylalkyl, -S(0 2

)

heteroarylalkyl, -S(0 2 )NH-cycloalkyl, -S(0 2 )NH-heterocyclyl, 15 S(0 2 )NH-cycloalkylalkyl, -S(0 2 )NH-heterocyclylalkyl, S(0 2 )NH-heteroarylalkyl, -S(0 2 )NT398T399, -S(0 2

)O

cycloalkyl, -S(0 2 )O-heterocyclyl, -S(0 2 )O-heteroaryl, -S(O2)O cycloalkylalkyl, -S(0 2 )O-heterocyclylalkyl, -S(0 2

)O

heteroarylalkyl, -P(O)(OH)2, -P(O)(OT400)(OT401), 20 Si(T402)(T403)(T404)"; with the further proviso that "-N(alkyl)2", "-C(O)N(alkyl) 2 ", C(O)N(cycloalkyl) 2 ", "-C(O)N(Aryl) 2 ", "-C(O)N(heteroaryl) 2 " are substituted further by at least one substituent selected from the following substituent group (ii); 25 where T368, T369, T370, T371, T372, T373, T374, T375, T376, T377, T378, T379, T380, T381, T382, T383, T384, T385, T386, T387, T388, T389, T390, T391, T392, T393, T394, T395, T396, T397, T398, T399, T400, T401, T402, T403, T404 are each independently selected from the group consisting of: "alkyl, (CO 30 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T374, T375 and/or T381, T382 and/or T391, T392 and/or T398, T399, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -122 where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 5 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, , CN, CF 3 , N 3 , NH 2 , -NHT405, -NT406T407, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T408, -C(O)O-T409, 10 -C(O)NH-T410, -C(O)NT411T412, -O-T413, -O(-T414 O)y-H (y = 1, 2, 3, 4, 5), -O(-T415-O)y--T416 (y = 1, 2, 3, 4, 5), -OC(O)-T417, -OC(O)-O-T418, -OC(O)-NHT419, -0 C(O)-NT420T421, -OP(O)(OT422)(OT423), OSi(T424)(T425)(T426), -OS(0 2 )-T427, -NHC(O)-T428, 15 NT429C(O)-T430, -NH-C(O)-O-T431, -NH-C(O)-NH T432, -NH-C(O)-NT433T434, -NT435-C(O)-O-T436, NT437-C(O)-NH-T438, -NT439-C(O)-NT440T441, NHS(0 2 )-T442, -NT443S(0 2 )-T444, -S-T445, -S(O)-T446, -S(0 2 )-T447, -S(0 2 )NH-T448, -S(0 2 )NT449T450, 20 S(0 2 )O-T451, -P(O)(OT452)(OT453), Si(T454)(T455)(T456)"; where T405, T406, T407, T408, T409, T410, T411, T412, T413, T414, T415, T416, T417, T418, T419, T420, T421, T422, T423, T424, T425,T426, T427,T428, T429, T430, 25 T431, T432, T433, T434,T435,T436, T437,T438, T439, T440, T441, T442, T443, T444,T445, T446,T447, T448, T449, T450, T451, T452, T453, T454, T455, T456 are each independently selected from the group consisting of: "alkyl,

(C

9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T41 1, T412 and/or T420, T421 and/or T433, T434 and/or T440, T441 and/or T449, T450, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 123 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT457, -NT458T459, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 10 P(O)(OH)2, -C(O)-T460, -C(O)O-T461, -C(O)NH-T462, -C(O)NT463T464, -O-T465, -O(-T466-O)z-H (z = 1, 2, 3, 4, 5), -O(-T467-O)z-T468 (z = 1, 2, 3, 4, 5), -OC(O) T469, -OC(O)-O-T470, -OC(O)-NHT471, -0-C(O) NT472T473, -OP(O)(OT474)(OT475), 15 OSi(T476)(T477)(T478), -OS(0 2 )-T479, -NHC(O)-T480, -NT481 C(O)-T482, -NH-C(O)-O-T483, -NH-C(O) NH-T484, -NH-C(O)-NT485T486, -NT487-C(O)-O T488, -NT489-C(O)-NH-T490, -NT491-C(O) NT492T493, -NHS(0 2 )-T494, -NT495S(0 2 )-T496, -S 20 T497, -S(O)-T498, -S(0 2 )-T499, -S(0 2 )NH-T500, S(0 2 )NT501T502, -S(0 2 )O-T503, P(O)(OT504)(OT505), -Si(T506)(T507)(T508)"; where T457, T458, T459, T460, T461, T462, T463, T464, T465,T466, T467, T468, T469, T470, T471,T472, T473, 25 T474, T475, T476, T477, T478, T479, T480, T481, T482, T483,T484, T485, T486,T487, T488, T489,T490, T491, T492, T493, T494, T495, T496, T497, T498,T499, T500, T501, T502, T503, T504, T505, T506, T507, T508 are each independently selected from the group consisting 30 of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T463, T464 and/or T472, T473 and/or T485, T486 and/or T492, T493 W02007/054556 PCT/EP20061068322 - 124 and/or T501, T502, in each case together, may also form "heterocyclyl"; or with the proviso that at least one of the Z28, Z29 radicals and at least 5 one of the Z30, Z31 radicals is independently selected from the group consisting of: (11) "(C 9

-C

30 )alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, -C(O)-(Cg-C 30 )alkyl, -C(O)-cycloalkyl, -C(O) cycloalkylalkyl, -C(O)-arylalkyl, -C(O)-heteroarylalkyl,

-C(O)

10 heterocyclyl, -C(O)-heterocyclylalkyl, -S(0 2 )-alkyl, -S(0 2 )-(Cg

C

30 )alkyl, -S(0 2 )-cycloalkyl, -S(0 2 )-cycloalkylalkyl, -S(0 2 )-aryl, S(02)-arylalkyl, -S(0 2 )-heteroaryl, -S(0 2 )-heteroarylalkyl, -S(O2) heterocyclyl, -S(0 2 )-heterocyclylalkyl"; where, optionally, the above substituents of substitution group (1l) 15 may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 20 Br, I, CN, CF 3 , N 3 , NH 2 , -NHT509, -NT51OT511, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T512, -C(O)O-T513, C(O)NH-T514, -C(O)NT515T516, -0-T517, -0(-T518-O)a-H (a = 1, 2, 3, 4, 5), -O(-T519-0)a-T520 (a = 1, 2, 3, 4, 5), 25 OC(O)-T521, -OC(O)-O-T522, -OC(O)-NHT523, -0-C(0) NT524T525, -OP(O)(OT526)(OT527), -OSi(T528)(T529)(T530), -OS(0 2 )-T531, -NHC(O)-T532, -NT533C(O)-T534,

-NH

C(O)-O-T535, -NH-C(O)-NH-T536, -NH-C(O)-NT537T538, NT539-C(O)-O-T540, -NT541-C(O)-NH-T542, -NT543 30 C(O)-NT544T545, -NHS(0 2 )-T546, -NT547S(0 2 )-T548, -S T549, -S(O)-T550, -S(0 2 )-T551, -S(0 2 )NH-T552, S(0 2 )NT553T554, -S(0 2 )O-T555, -P(O)(OT556)(OT557), Si(T558)(T559)(T560)"; W02007/054556 PCTIEP2006/068322 -125 where T509, T510, T511, T512, T513, T514, T515, T516, T517, T518, T519, T520,T521, T522, T523,T524, T525, T526, T527, T528, T529, T530,T531,T532,T533,T534, T535, T536, T537, T538, T539, T540,T541, T542, T543,T544, T545,T546, T547, 5 T548, T549, T550,T551,T552,T553,T554, T555, T556, T557, T558, T559, T560 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T515, T516 10 and/or T524, T525 and/or T537, T538 and/or T544, T545 and/or T553, T554, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 15 consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT561, -NT562T563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 20 -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T564, -C(O)O-T565, -C(O)NH-T566, -C(O)NT567T568, -O-T569, -O(-T570 O)b-H (b = 1, 2, 3, 4, 5), -O(-T571-O)b-T572 (b = 1, 2, 3, 4, 5), -OC(O)-T573, -OC(O)-O-T574, -OC(O)-NHT575, -0 C(O)-NT576T577, -OP(O)(OT578)(OT579), 25 OSi(T580)(T581)(T582), -OS(O 2 )-T583, -NHC(O)-T584, NT585C(O)-T586, -NH-C(O)-0-T587, -NH-C(O)-NH T588, -NH-C(O)-NT589T590, -NT591-C(O)-O-T592, NT593-C(O)-NH-T594, -NT595-C(O)-NT596T597, NHS(0 2 )-T598, -NT599S(0 2 )-T600, -S-T601, -S(O)-T602, 30 -S(0 2 )-T603, -S(0 2 )NH-T604, -S(0 2 )NT605T606, S(0 2 )O-T607, -P(O)(OT608)(OT609), Si(T61 0)(T61 1)(T612)"; where T561, T562, T563, T564, T565, T566, T567, T568, T569, T570, T571, T572, T573, T574, T575, T576, T577, W02007/054556 PCT/EP2006/068322 - 126 T578, T579, T580, T581, T582,T583, T584,T585, T586, T587, T588, T589, T590, T591, T592, T593, T594, T595, T596, T597, T598, T599, T600, T601, T602, T603, T604, T605, T606, T607, T608, T609, T610, T611, T612 are each 5 independently selected from the group consisting of: "alkyl,

(C

9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T567, T568 and/or T576, T577 and/or T589, T590 and/or T596, T597 and/or T605, T606, in 10 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT613, -NT614T615, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 20

P(O)(OH)

2 , -C(O)-T616, -C(O)O-T617, -C(O)NH-T618, -C(O)NT619T620, -O-T621, -O(-T622-O)c-H (c = 1, 2, 3, 4, 5), -O(-T623-O)e-T624 (c = 1, 2, 3, 4, 5), -OC(O) T625, -OC(O)-O-T626, -OC(O)-NHT627, -0-C(O) NT628T629, -OP(O)(OT630)(OT631), 25 OSi(T632)(T633)(T634), -OS(0 2 )-T635, -NHC(O)-T636, -NT637C(O)-T638, -NH-C(O)-O-T639, -NH-C(O) NH-T640, -NH-C(O)-NT641T642, -NT643-C(O)-O T644, -NT645-C(O)-NH-T646, -NT647-C(O) NT648T649, -NHS(0 2 )-T650, -NT651S(0 2 )-T652, -S 30 T653, -S(O)-T654, -S(0 2 )-T655, -S(0 2 )NH-T656, S(0 2 )NT657T658, -S(0 2 )O-T659, P(O)(OT660)(OT661), -Si(T662)(T663)(T664)"; where T613, T614, T615, T616, T617, T618, T619, T620, T621,T622, T623, T624,T625,T626, T627,T628, T629, W02007/054556 PCT/EP2006/068322 -127 T630, T631, T632, T633, T634, T635, T636, T637, T638, T639, T640, T641, T642, T643, T644, T645, T646, T647, T648, T649, T650, T651, T652, T653, T654, T655, T656, T657, T658, T659, T660, T661, T662, T663, T664 are 5 each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T619, T620 and/or T628, T629 and/or T641, T642 and/or T648, T649 10 and/or T657, T658, in each case together, may also form "heterocyclyl"; and one of the Z28, Z29 radicals or neither of the Z28, Z29 radicals and one of the Z30, Z31 radicals or neither of the Z30, Z31 radicals and the 15 Z32 radical is independently selected from the group consisting of: (lll)"hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C(O) alkyl, -C(O)-aryl, -C(O)-heteroaryl"; where, optionally, the above substituents of substituent group (1ll) may each independently in turn be substituted by at least one 20 substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT665, -NT666T667, -NO 2 , -OH, 25

OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T668, -C(O)O-T669, C(O)NH-T670, -C(O)NT671T672, -O-T673, -O(-T674-O)-H (d = 1, 2, 3, 4, 5), -O(-T675-O)d-T676 (d = 1, 2, 3, 4, 5), OC(O)-T677, -OC(O)-O-T678, -OC(O)-NHT679, -0-C(O) 30 NT680T681, -OP(O)(OT682)(OT683), -OSi(T684)(T685)(T686), -OS(0 2 )-T687, -NHC(O)-T688, -NT689C(O)-T690,

-NH

C(O)-O-T691, -NH-C(O)-NH-T692, -NH-C(O)-NT693T694, NT695-C(O)-O-T696, -NT697-C(O)-NH-T698, -NT699- W02007/054556 PCT/EP2006/068322 - 128 C(O)-NT700T701, -NHS(0 2 )-T702, -NT703S(0 2 )-T704, -S T705, -S(O)-T706, -S(0 2 )-T707, -S(0 2 )NH-T708, S(0 2 )NT709T710, -S(0 2 )O-T7 11, -P(O)(OT712)(OT713), Si(T714)(T715)(T716)"; 5 where T665, T666, T667, T668, T669, T670, T671, T672, T673, T674, T675, T676, T677, T678,T679, T680,T681, T682, T683, T684, T685, T686, T687, T688, T689, T690,T691, T692, T693, T694, T695, T696, T697, T698, T699, T700,T701, T702, T703, T704, T705, T706, T707,T708, T709,T710,T711, T712, T713, 10 T714, T715, T716 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T671, T672 and/or T680, T681 and/or T693, T694 and/or T700, T701 and/or 15 T709, T710, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 20 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT717, -NT718T719, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T720, -C(O)O-T721, 25 -C(O)NH-T722, -C(O)NT723T724, -O-T725, -O(-T726 O),-H (e = 1, 2, 3, 4, 5), -O(-T727-0)-T728 (e = 1, 2, 3, 4, 5), -OC(O)-T729, -OC(O)-O-T730, -OC(O)-NHT731, -0 C(O)-NT732T733, -OP(O)(OT734)(OT735), OSi(T736)(T737)(T738), -OS(0 2 )-T739, -NHC(O)-T740, 30 NT741 C(O)-T742, -NH-C(O)-O-T743, -N H-C(O)-N H T744, -NH-C(O)-NT745T746, -NT747-C(O)-O-T748, NT749-C(O)-NH-T750, -NT751-C(O)-NT752T753, NHS(0 2 )-T754, -NT755S(0 2 )-T756, -S-T757, -S(O)-T758, -S(0 2 )-T759, -S(0 2 )NH-T760, -S(0 2 )NT761T762, - W02007/054556 PCT/EP2006/068322 - 129 S(0 2 )O-T763, -P(O)(OT764)(OT765), Si(T766)(T767)(T768)"; where T717, T718, T719, T720, T721, T722, T723, T724, T725, T726, T727, T728, T729, T730, T731, T732, T733, 5 T734, T735, T736, T737, T738, T739, T740, T741, T742, T743, T744, T745, T746, T747, T748, T749, T750, T751, T752,T753, T754,T755,T756,T757, T758, T759, T760, T761, T762, T763, T764, T765, T766, T767, T768 are each independently selected from the group consisting of: "alkyl, 10 (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T723, T724 and/or T732, T733 and/or T745, T746 and/or T752, T753 and/or T761, T762, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) alkyll, (CO-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 20 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT769, -NT770T771, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T772, -C(O)O-T773, -C(O)NH-T774, 25 -C(O)NT775T776, -O-T777, -O(-T778-O)r-H (f = 1, 2, 3, 4, 5), -O(-T779-O)r-T780 (f = 1, 2, 3, 4, 5), -OC(O) T781, -OC(O)-O-T782, -OC(O)-NHT783, -0-C(O) NT784T785, -OP(O)(OT786)(OT787), OSi(T788)(T789)(T790), -OS(0 2 )-T791, -NHC(O)-T792, 30 -NT793C(O)-T794, -NH-C(O)-O-T795, -NH-C(O) NH-T796, -NH-C(O)-NT797T798, -NT799-C(O)-O T800, -NT801-C(O)-NH-T802, -NT803-C(O) NT804T805, -NHS(0 2 )-T806, -NT807S(O 2 )-T808, -S T809, -S(O)-T810, -S(O 2 )-T811, -S(0 2 )NH-T812, - W02007/054556 PCT/EP2006/068322 -130 S(0 2 )NT813T814, -S(0 2 )O-T815, P(O)(OT816)(OT817), -Si(T818)(T819)(T820)"; where T769, T770, T771, T772, T773, T774, T775, T776, T777, T778, T779, T780, T781, T782, T783, T784, T785, 5 T786, T787, T788, T789, T790, T791, T792, T793, T794, T795, T796, T797, T798, T799,T800, T801,T802, T803, T804, T805, T806, T807, T808, T809, T810, T811, T812, T813, T814, T815, T816, T817, T818, T819, T820 are each independently selected from the group consisting 10 of: "alkyl, (C-C 3 o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T775, T776 and/or T784, T785 and/or T797, T798 and/or T804, T805 and/or T813, T814, in each case together, may also form 15 "heterocyclyl"; (2) "-C(Y5)NZ33-Y6-Z34"; where Y5, Y6 are each independently selected from the group consisting of "O, S, =NH, =NZ35"; 20 where Z33, Z34, Z35 are each independently selected from the group consisting of: (1) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O)-alkyl, -C(O)-(C-C 30 )alkyl, -C(O)-cycloalkyl, 25 -C(O)-cycloalkylalkyl, -C(O)-aryl, -C(O)-arylalkyl, -C(O) heteroaryl, -C(O)-heteroarylalkyl, -C(O)-heterocyclyl, -C(O) heterocyclylalkyl, -S(0 2 )-alkyl, -S(0 2

)-(C-C

3 )alkyl, -S(O2) cycloalkyl, -S(0 2 )-cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2 )-arylalkyl, S(0 2 )-heteroaryl, -S(0 2 )-heteroarylalkyl, -S(0 2 )-heterocyclyl, 30 S(0 2 )-heterocyclylalkyl"; where, optionally, the above substituents of substituent group (1) may each independently in turn be substituted by at least one W02007/054556 PCT/EP2006/068322 - 131 substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 5 Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT821, -NT822T823, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T824, -C(O)O-T825, C(O)NH-T826, -C(O)NT827T828, -0-T829, -O(-T830-O)g-H (g = 1, 2, 3, 4, 5), -O(-T831-O)g-T832 (g = 1, 2, 3, 4, 5), 10 OC(O)-T833, -OC(O)-O-T834, -OC(O)-NHT835, -O-C(O) NT836T837, -OP(O)(OT838)(OT839), -OSi(T840)(T814)(T842), -OS(0 2 )-T843, -NHC(O)-T844, -NT845C(O)-T846, -NH C(O)-O-T847, -NH-C(O)-NH-T848, -NH-C(O)-NT849T850, NT851-C(O)-O-T852, -NT853-C(O)-NH-T854, -NT855 15 C(O)-NT856T857, -NHS(0 2 )-T858, -NT859S(0 2 )-T860, -S T861, -S(O)-T862, -S(0 2 )-T863, -S(0 2 )NH-T864, S(0 2 )NT865T866, -S(0 2 )O-T867, -P(O)(OT868)(OT869), Si(T870)(T871)(T872)"; where T821, T822, T823, T824, T825, T826, T827, T828, T829, 20 T830, T831, T832, T833, T834, T835, T836, T837, T838, T839, T840, T841, T842, T843, T844, T845, T846, T847, T848, T849, T850, T851, T852, T853, T854, T855, T856, T857, T858, T859, T860, T861, T862, T863, T864, T865, T866, T867, T868, T869, T870, T871, T872 are each independently selected from the 25 group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T827, T828 and/or T836, T837 and/or T849, T850 and/or T856, T857 and/or T865, T866, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 -132 (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT873, -NT874T875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 5 -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T876, -C(O)O-T877, -C(O)NH-T878, -C(O)NT879T880, -O-T881, -O(-T882 O)h-H (h = 1, 2, 3, 4, 5), -O(-T883-O)h-T884 (h = 1, 2, 3, 4, 5), -OC(O)-T885, -OC(O)-O-T886, -OC(O)-NHT887, -0 C(O)-NT888T889, -OP(O)(OT890)(OT891), 10 OSi(T892)(T893)(T894), -OS(O 2 )-T895, -NHC(O)-T896, NT897C(O)-T898, -NH-C(O)-O-T899, -NH-C(O)-NH T900, -NH-C(O)-NT901T902, -NT903-C(O)-O-T904, NT905-C(O)-NH-T906, -NT907-C(O)-NT908T909, NHS(0 2 )-T91 0, -NT91 1 S(0 2 )-T912, -S-T913, -S(O)-T914, 15 -S(0 2 )-T915, -S(0 2 )NH-T916, -S(0 2 )NT917T918, S(0 2 )O-T919, -P(O)(OT920)(OT921), Si(T922)(T923)(T924)"; where T873, T874, T875, T876, T877, T878, T879, T880, T881, T882,T883, T884,T885, T886, T887, T888, T889, 20 T890, T891,T892, T893,T894,T895,T896, T897, T898, T899, T900,T901, T902,T903,T904,T905,T906, T907, T908, T909, T910, T911, T912, T913, T914, T915, T916, T917, T918, T919, T920, T921, T922, T923, T924 are each independently selected from the group consisting of: "alkyl, 25 (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T879, T880 and/or T888, T889 and/or T901, T902 and/or T908, T909 and/or T917, T918, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 -133 (iii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT925, -NT926T927, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, 5 OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T928, -C(O)O-T929, -C(O)NH-T930, -C(O)NT931T932, -O-T933, -O(-T934-O)i-H (i = 1, 2, 3, 4, 5), -O(-T935-O)r-T936 (i = 1, 2, 3, 4, 5), -OC(O) T937, -OC(O)-O-T938, -OC(O)-NHT939, -0-C(O) 10 NT940T941, -OP(O)(OT942)(OT943), OSi(T944)(T945)(T946), -OS(0 2 )-T947, -NHC(O)-T948, -NT949C(O)-T950, -NH-C(O)-O-T951, -NH-C(O) NH-T952, -NH-C(O)-NT953T954, -NT955-C(O)-O T956, -NT957-C(O)-NH-T958, -NT959-C(O) 15 NT960T961, -NHS(0 2 )-T962, -NT963S(0 2 )-T964, -S T965, -S(O)-T966, -S(0 2 )-T967, -S(0 2 )NH-T968, S(0 2 )NT969T970, -S(0 2 )O-T971, P(O)(OT972)(OT973), -Si(T974)(T975)(T976)"; where T925, T926, T927, T928, T929, T930, T931, T932, 20 T933, T934, T935, T936, T937,T938, T939, T940, T941, T942, T943, T944, T945,T946,T947, T948,T949, T950, T951, T952, T953, T954, T955,T956, T957, T958, T959, T960, T961, T962, T963, T964, T965, T966, T967, T968, T969, T970, T971, T972, T973, T974, T975, T976 are 25 each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T931, T932 and/or T940, T941 and/or T953, T954 and/or T960, T961 30 and/or T969, T970, in each case together, may also form "heterocyclyl"; and one of the Z26, Z27 radicals or neither of the Z26, Z27 radicals is also independently selected from the group consisting of: W02007/054556 PCT/EP2006/068322 -134 (2) "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O)-alkyl,

-C(O)-(C-C

30 )alkyl, -C(O)-cycloalkyl, -C(O)-cycloalkylalkyl,

-C(O)

aryl, -C(0)-arylalkyl, -C(O)-heteroaryl, -C(O)-heteroarylalkyl, -C(0) 5 heterocyclyl, -C(O)-heterocyclylalkyl, -C(Y7)NZ36Z37, -C(=NZ38) Z39, -S(0 2 )-alkyl, -S(0 2

)-(C

9

-C

3 )alkyl, -S(0 2 )-cycloalkyl, -S(0 2

)

cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2 )-arylalkyl, -S(0 2 )-heteroaryl, S(0 2 )-heteroarylalkyl, -S(0 2 )-heterocyclyl, -S(0 2 )-heterocyclylalkyl"; where Y7 is independently selected from the group consisting of "0, S, 10 =NH, =NZ40"; where the Z36, Z37, Z38, Z39, Z40 radicals are each independently selected from the group consisting of: (1) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) 15 alkyl, -C(O)-(Cg-C 30 )alkyl, -C(O)-cycloalkyl, -C(O)-cycloalkylalkyl, -C(O)-aryl, -C(O)-arylalkyl, -C(O)-heteroaryl, -C(O) heteroarylalkyl, -C(O)-heterocyclyl, -C(O)-heterocyclylalkyl, S(0 2 )-alkyl, -S(0 2

)-(C-C

30 )alkyl, -S(0 2 )-cycloalkyl, -S(02) cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2 )-arylalkyl, -S(0 2 )-heteroaryl, 20 S(0 2 )-heteroarylalkyl, -S(0 2 )-heterocyclyl, -S(O2) heterocyclylalkyl"; where, optionally, the above substituents of substituent group (3) and/or substituent group (I) may each independently in turn be substituted by at least one substituent selected identically or differently from the group 25 consisting of: (i) alkyll, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT977, -NT978T979, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 30 P(O)(OH) 2 , -C(O)-T980, -C(O)O-T981, -C(O)NH-T982, C(O)NT983T984, -O-T985, -O(-T986-O)j-H (j = 1, 2, 3, 4, 5), -O( T987-O);-T988 (j = 1, 2, 3, 4, 5), -OC(O)-T989, -OC(O)-O-T990, OC(O)-NHT991, -O-C(O)-NT992T993, -OP(O)(OT994)(OT995), - W02007/054556 PCT/EP2006/068322 -135 OSi(T996)(T997)(T998), -OS(0 2 )-T999, -NHC(O)-T1000, NT1001C(O)-T1002, -NH-C(O)-O-T1003, -NH-C(O)-NH-T1004, -NH-C(O)-NT1005T1006, -NT1007-C(O)-0-T1008, -NT1009 C(O)-NH-T1010, -NT1011-C(O)-NT1012T1013, -NHS(0 2

)

5 T1014, -NT1015S(0 2 )-T1016, -S-T1017, -S(O)-T1018, -S(0 2

)

T1019, -S(0 2 )NH-T1020, -S(0 2 )NT1021T1022, -S(0 2 )O-T1023, P(O)(OT1 024)(OT1 025), -Si(T1 026)(T1 027)(T1 028)"; where T977, T978, T979, T980, T981, T982, T983, T984, T985, T986, T987, T988, T989, T990,T991,T992, T993,T994, T995, 10 T996, T997, T998, T999,T1OO,T1O1, T1OO2,T1003, T1004, T1 005, T1006, T1 007, T1008, T1 009, T1010, T1011, T1012, T1013, T1014, T1015, T1016, T1017, T1018, T1019, T1020, T1021, T1022, T1 023, T1 024, T1 025, T1 026, T1 027, T1 028 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, 15 cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T983, T984 and/or T992, T993 and/or T1005, T1006 and/or T1012, T1013 and/or T1021, T1022, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1029, -NT1030T1031, -NO 2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1032, -C(O)O-T1033, C(O)NH-T1034, -C(O)NT1035T1036, -O-T1037, -O(-T1038 30 O)k-H (k = 1, 2, 3, 4, 5), -0(-Ti 039-O)k-T1 040 (k = 1, 2, 3, 4, 5), -OC(O)-T1041, -OC(O)-O-T1042, -OC(O)-NHT1043, -0 C(O)-NT1044T1045, -OP(O)(OT1046)(OT1047), OSi(T1 048)(T1 049)(T1 050), -OS(0 2 )-T1 051, -NHC(O)-T1 052, -NT1053C(O)-T1054, -NH-C(O)-O-T1055, -NH-C(O)-NH- W02007/054556 PCT/EP2006/068322 -136 T1056, -NH-C(O)-NT1057T1058, -NT1059-C(O)-O-T1060, NT1061-C(O)-NH-T1062, -NT1063-C(O)-NT1064T1065, NHS(0 2 )-T1066, -NT1067S(0 2 )-T1068, -S-T1069, -S(O) T1070, -S(0 2 )-T1071, -S(0 2 )NH-T1072, -S(0 2 )NT1073T1074, 5 -S(0 2 )O-T1075, -P(O)(OT1076)(OT1077), Si(T1 078)(T1 079)(T1 080)"; where T1029, T1030, T1031, T1032, T1033, T1034, T1035, T1036, T1037, T1038, T1039,T1040, Ti041, T1042, T1043, T1044, T1045, T1046, T1047,T1048, T1049, T1O5O, T1O51, 10 T1052, T1053, T1054, T1O55, T1056, T1057, T1058, T1059, T1060, T1O61,T1062, T1063,T1064, T1065, T1066, T1067, T1068, T1069, T1070, T1071,T1072, T1073, T1074,T1075, T1076, T1077, T1078, T1079, T1080 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, 15 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1035, T1036 and/or T1044, T1045 and/or T1057, T1058 and/or T1064, T1065 and/or T1073, T1074, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cq-C3o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF, N 3 , NH 2 , -NHT1081, -NT1082T1083, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1084, C(O)O-T1085, -C(O)NH-T1086, -C(O)NT1087T1088, -0 30 T1089, -O(-T1090-O)rH (I = 1, 2, 3, 4, 5), -O(-T1091-O)r T1 092 (1 = 1, 2, 3, 4, 5), -OC(O)-T1 093, -OC(O)-O-T1094, -OC(O)-NHT1095, -O-C(O)-NT1096T1097, OP(O)(OT1098)(OT1099), -OSi(T1 100)(T1 101)(T1102), OS(0 2 )-T1103, -NHC(O)-T1104, -NT1105C(O)-T1106, - W02007/054556 PCT/EP20061068322 -137 NH-C(O)-O-T1 107, -NH-C(O)-NH-Ti 108, -NH-C(O) NT1109T1110, -NT1111-C(O)-O-T1112, -NT1113-C(O) NH-T1114, -NT1115-C(O)-NT1116T1117, -NHS(0 2

)

T1118, -NT1119S(0 2 )-T1120, -S-T1121, -S(O)-T1122, 5 S(0 2 )-T1123, -S(0 2 )NH-T1124, -S(0 2 )NT1125T1126, S(0 2 )O-T1 127, -P(O)(OT1 128)(OT1 129), Si(T1 130)(T1 131)(T1 132)"; where T1081, T1082, T1083, T1084, T1085, T1086, T1087, T1088, T1089, T109O, T1091, T1092, T1093, T1094, T1095, 10 T1096, T1097, T1098,T1099, T1100, T1101,T1102, T1103, T1104,T1105,T1106,T1107,T1108,T1109,T1110,T1111, T1112, T1113, T1114,Till5, T1116, T1117,T1118, T1119, T1120, T1121, T1122,T1123, T1124, T1125,T1126, T1127, T1128, T1129, T1130, T1131, T1132 are each independently 15 selected from the group consisting of: "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 087, T1 088 and/or T1 096, T1 097 and/or T1109, T1110 and/or T1116, T1117 and/or T1125, T1126, in 20 each case together, may also form "heterocyclyl"; and one of the Z1, Z2 radicals or neither of the Z1, Z2 radicals is independently selected from the group consisting of: (c) hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1133, -NT1134T1135, -NO 2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T1136, -C(O)O-T1137, -C(O)NH-T1138, C(O)NT1139T1140, -0-T1141, -0(-T1142-0)m-H (m = 1, 2, 3, 4, 5), 30 O(-T1143-O)m-T1144 (m = 1, 2, 3, 4, 5), -OC(O)-T1145, -OC(O)-O T1 146, -OC(O)-NHT1 147, -O-C(O)-NT1148T1149, OP(O)(OTi 150)(OT1 151), -OSi(T1 152)(T1 153)(T1 154), -OS(0 2 )-T1 155, -NHC(O)-T1 156, -NT1 157C(O)-T1158, -NH-C(O)-O-T1 159, -NH- W02007/054556 PCT/EP2006/068322 - 138 C(O)-NH-T1160, -NH-C(O)-NT1161T1162, -NT1163-C(O)-O-T1164, -NT1 165-C(O)-NH-Ti 166, -NT1 167-C(O)-NT1 168T1 169, -NHS(0 2

)

T1 170, -NT1 171 S(0 2 )-T1 172, -S-T1 173, -S(O)-Ti 174, -S(0 2 )-T1 175,

-S(O

2 )NH-T1 176, -S(O 2 )NT 177T1 178, -S(0 2 )O-T1 179, 5 P(O)(OT1180)(OT1181), -Si(T1182)(T1183)(T1184)"; where T1133, T1134, T1135, T1136, T1137, T1138, T1139, T1140, T1141,Tii42, T1143, T1144, T1145, T1146,T1147, T1148, T1149, T1150, T1l51, T1152, Tii53, T1154, T1155, T1156, T1157, T1158, T1159, T116O, Tii6, T1162, T1163, T1164, T1165, T1166, T1167, 10 T1168,T1169,T117O,T117l,T1172,T1173,T1174,T1175,T1176, T1177, T1178, T1179, T1180, T1181, T1182, T1183, T1184 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1139, T1140 and/or 15 T1148, T1149 and/or T1161, T1162 and/or T1168, T1169 and/or T1177, T1 178, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (c) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 20 (i) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1185, -NT1186T1187, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Ti 188, -C(O)O-TI 189, -C(O)NH-Ti 190, 25 C(O)NT1 191T1 192, -0-T1 193, -O(-T 1194-0),-H (n = 1, 2, 3, 4, 5), -O(-T1195-O),-T1196 (n = 1, 2, 3, 4, 5), -OC(O)-T1197, -OC(O) O-T1 198, -OC(O)-NHT1 199, -0-C(O)-NT1200T1201, OP(O)(OT1202)(OT1203), -OSi(T1204)(T1205)(T1206), -OS(0 2

)

T1 207, -NHC(O)-T1 208, -NT1209C(O)-T1210, -NH-C(O)-O 30 T1211, -NH-C(O)-NH-T1212, -NH-C(O)-NT1213T1214, -NT1215 C(O)-4-T1216, -NT1217-C(O)-NH-T1218, -NT1219-C(O) NT1220T1221, -NHS(0 2 )-T1222, -NT1223S(O 2 )-T1224, -S-T1225, -S(O)-Ti226, -S(0 2 )-T1227, -S(0 2 )NH-T1228, - W02007/054556 PCT/EP2006/068322 -139 S(0 2 )NT1229T1230, -S(0 2 )0-T1231, -P(O)(OT1232)(OT1233), Si(T1234)(T1235)(T1236)"; where T1185, T1186, T1187, T1188, T1189, T1190, T1191, T1192, T1193, T1194, T1195, T1196, T1197, T1198, T1199, T1200, T120, 5 T1202, T1203, T1204, T1205, T1206, T1207, T1208, T1209, T1210, T1211, T1212, T1213, T1214, T1215, T1216, T1217, T1218, T1219, T1220, T1221, T1222, T1223, T1224, T1225, T1226, T1227, T1228, T1229, T1230, T1231, T1232, T1 233, T1 234, T1 235, T1236 are each independently selected from the group consisting of: "alkyl, (Cg 10 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1191, T1192 and/or T1200, T1201 and/or T1213, T1214 and/or T1220, T1221 and/or T1229, T1230, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 20 Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT1237, -NT1238T1239, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-T1240, -C(O)O-Ti 241, -C(O)NH T1242, -C(O)NT1243T1244, -O-T1245, -O(-T1246-0)-H (o = 1, 2, 3, 4, 5), -O(-T1247-O)o-T1248 (o = 1, 2, 3, 4, 5), -OC(O) 25 T1249, -OC(O)-O-T1250, -OC(O)-NHT1251, -0-C(0) NT1252T1253, -OP(O)(OT1254)(OT1255), OSi(T1256)(T1257)(T1258), -OS(O 2 )-T1259, -NHC(O)-T1260, NT1261C(O)-T1262, -NH-C(O)-O-T1263, -NH-C(O)-NH T1264, -NH-C(0)-NT1265T1266, -NT1267-C(O)-O-T1268, 30 NT1269-C(O)-NH-T1270, -NT1271-C(O)-NT1272T1273, NHS(0 2 )-T1274, -NT1275S(0 2 )-T1276, -S-T1277, -S(O) T1278, -S(0 2 )-T1279, -S(0 2 )NH-T1280, -S(0 2 )NT1281T1282, S(0 2 )O-T1283, -P(O)(OT1284)(OT1285), Si(T1 286)(T1 287)(T1 288)"; W02007/054556 PCT/EP2006/068322 - 140 where T1237, T1238, T1239, T1240, T1241, T1242, T1243, T1244, T1245, T1246,T1247, T1248, T1249, T1250, T1251, T1252, T1253, T1254, T1255, T1256, T1257, T1258, T1259, T1260, T1261, T1262,T1263, T1264, Ti265, T1266, T1267, 5 T1268, T1269, T1270,T1271, T1272, T1273, T1274, T1275, T1276, T1277, T1278,T1279, T1280, T1281, T1282,T1283, T1284, T1285, T1286, T1287, T1288 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 10 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1243, T1244 and/or T1252, T1253 and/or T1265, T1266 and/or T1272, T1273 and/or T1281, T1282, in each case together, may also form "heterocyclyl"; 15 (d) -NZ41Z42 where the Z41, Z42 radicals are each independently selected from the group consisting of: (1) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocycylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) alkyl, -C(O)-(C-C 30 )alkyl, -C(O)-cycloalkyl, -C(O)-cycloalkylalkyl, 20 C(O)-aryl, -C(O)-arylalkyl, -C(O)-heteroaryl, -C(O)-heteroarylalkyl, -C(O)-heterocyclyl, -C(O)-heterocyclylalkyl"; where, optionally, the above substituents of substituent group (1) may each independently be substituted further by at least one substituent selected identically or differently from the group consisting of: 25 (i) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1289, -NT129OT1291, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-T1292, -C(O)O-T1293, -C(O)NH 30 T1 294, -C(O)NT1295T1296, -O-T1297, -O(-T1298-O)r-H (rr = 1, 2, 3, 4, 5), -O(-T1 299-O)r-T1 300 (rr = 1, 2, 3, 4, 5), -OC(O) T1301, -OC(O)-0-T1302, -OC(O)-NHT1303, -0-C(O) NT1 304T1 305, -OP(O)(OT1 306)(OT1 307), - W02007/054556 PCT/EP2006/068322 - 141 OSi(T1 308)(T1 309)(T1 310), -OS(0 2 )-T1 311, -NHC(O)-T1 312, NT1 313C(O)-Ti 314, -NH-C(O)-O-T1 315, -NH-C(O)-NH T1316, -NH-C(O)-NT1317T1318, -NT1319-C(O)-O-T1320, NT1 321-C(O)-NH-Ti 322, -NT1 323-C(O)-NT1 324T1 325, 5 NHS(0 2 )-T1 326, -NT1 327S(0 2 )-T1 328, -S-T1 329, -S(O) T1 330, -S(0 2 )-T1 331, -S(0 2 )NH-T1 332, -S(0 2 )NT1 333T1 334, S(O 2 )O-T1 335, -P(O)(OT1 336)(OT1 337), Si(T1 338)(T1 339)(T1 340)"; where T1289, T1290, T1291, T1292, T1293, T1294, T1295, 10 T1296, T1297, T1298, T1299,T1300, T130, T1302, T1303, T1304, T1305, T1306, T1307, T1308, T1309, T131O, Tl311, T1312,T1313, T1314, T1315,T1316, T1317, Ti318, T1319, T1320, T1321, T1322, T1323,T1324,T1325, T1326, T1327, T1328, T1329, T1330, T1331, T1332,T1333, T1334, T1335, 15 T1 336, T1 337, T1 338, T1 339, T1340 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1295, T1296 and/or T1304, T1305 and/or T1317, T1318 and/or 20 T1 324, T1 325 and/or T1 333, T1334, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group 25 consisting of: (ii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1341, -NT1342T1343, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 30 -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1344, -C(O)O T1345, -C(O)NH-T1346, -C(O)NT1347T1348, -O-T1349, O(-T1350-O)rs-H (rs = 1, 2, 3, 4, 5), -O(-T1351-0),,-T1 352 (rs = 1, 2, 3, 4, 5), -OC(O)-T1353, -OC(O)-O-T1354, OC(O)-NHT1 355, -O-C(O)-NT1 356T1 357, - W02007/054556 PCT/EP2006/068322 - 142 OP(O)(OT1 358)(OT1 359), -OSi(T1 360)(T1 361)(T1 362), OS(O 2 )-T1 363, -NHC(O)-T1 364, -NT1 365C(O)-Ti 366, NH-C(O)-O-T1367, -NH-C(O)-NH-Ti 368, -NH-C(O) NT1 369T1 370, -NT1 371-C(O)-O-T1 372, -NT1 373-C(O) 5 NH-T1374, -NT1375-C(O)-NT1376T1377, -NHS(0 2 )-T1378, -NT1 379S(0 2 )-T1 380, -S-T1 381, -S(O)-T1382, -S(0 2

)

T1 383, -S(0 2 )NH-T1 384, -S(0 2 )NT1 385T1 386, -S(0 2

)O

T1 387, -P(O)(OT1 388)(OT1 389), -Si(T1 390)(T1 391)(T1 392)"; where T1341, T1342, T1343, T1344, T1345, T1346, T1347, 10 T1348, T1349, T1350, T1351, T1352, T1353, T1354, T1355, T1356, T1357, T1358, T1359, T1360, T1361, T1362, T1363, T1364, T1365, T1366, T1367, T1368, T1369, T1370, T1371, T1372, T1373, T1374, T1375, T1376, T1377, T1378, T1379, T1380, T1381, T1382, T1383, T1384, T1385, T1386, T1387, 15 T1 388, T1 389, T1 390, T1 391, T1 392 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1347, T1348 and/or T1356, T1357 and/or T1369, T1370 20 and/or T1 376, T1 377 and/or T1 385, T1 386, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the 25 group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1393, -NT1394T1395,

-NO

2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, 30 -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Ti 396, C(O)O-T1 397, -C(O)NH-T1 398, -C(O)NT1 399T1 400, O-T1401, -O(-T1402-O)r-H (rt = 1, 2, 3, 4, 5), -O( T1403-O)r-T1404 (rt = 1, 2, 3, 4, 5), -OC(O)-T1405, OC(O)-O-T1406, -OC(O)-NHT1407, -0-C(O)- W02007/054556 PCT/EP2006/068322 - 143 NT1408T1409, -OP(O)(OT1410)(OT1411), OSi(T1412)(T1 413)(T1414), -OS(02)-T1 415, -NHC(O) T1416, -NT1417C(O)-T1418, -NH-C(O)-O-T1419, -NH C(O)-NH-T1420, -NH-C(O)-NT1421T1422, -NT1423 5 C(O)-O-T1424, -NT1425-C(O)-NH-T1426, -NT1427 C(O)-NT1428T1429, -NHS(0 2 )-T1430, -NT1431S(0 2

)

T1432, -S-T1433, -S(O)-T1434, -S(0 2 )-T1435, S(0 2 )NH-T1436, -S(0 2 )NT1437T1438, -S(0 2 )O-T1439, P(O)(OT1440)(OT1441), -Si(T1442)(T1443)(T1444)"; 10 where T1393, T1394, T1395, T1396, T1397, T1398, T1399, T1400, T1401, T1402, T1403, T1404, T1405, T1406,T14O7, Ti408, T1409, T14lO, T1411, T1412, T1413, T1414, T1415, T1416, T1417, T1418,T1419, T1420, T1421, T1422, T1423, T1424, T1425,Ti426, 15 T1427, Ti428, T1429, T1430, T1431, T1432,Ti433, T1434, T1435, Ti436, Ti437, Ti438, Ti439,T1440, T1441, T1442, T1443, T1444 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 20 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1399, T1400 and/or T1408, T1409 and/or T1421, T1422 and/or T1428, T1429 and/or T1437, T1438, in each case together, may also form "heterocyclyl"; 25 (2) "-C(O)-C(O)-T1445, -S(0 2 )-NT1446T1447"; where T1445, T1446, T1447 are each independently selected from the group consisting of: (1) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 30 heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1448, NT1449T1450, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-T1451, -C(O)O-T1452, -C(O)NH-T1453, - W02007/054556 PCT/EP2006/068322 -144 C(O)NT1454T1455, -O-T1456, -O(-T1457-O).-H (ru = 1, 2,3, 4, 5), -O(-T1458-O)r-T1459 (ru = 1, 2, 3, 4, 5), -OC(O)-T1460, -OC(O)-O-T1461, -OC(O)-NHT1462, -O-C(O)-NT1463T1464, -OP(O)(OT1 465)(OT1 466), -OSi(T1 467)(T1 468)(T1 469), 5 OS(0 2 )-T1470, -NHC(O)-T1471, -NT1472C(O)-T1473, -NH C(O)-O-T1474, -NH-C(O)-NH-T1475, -NH-C(O) NT1476T1477, -NT1478-C(O)-O-T1479, -NT1480-C(O)-NH T1481, -NT1482-C(O)-NT1483T1484, -NHS(O 2 )-T1485, NT1486S(0 2 )-T1487, -S-T1488, -S(O)-T1489, -S(0 2 )-T1490, 10 S(0 2 )NH-T1491, -S(0 2 )NT1492T1493, -S(0 2 )O-T1494, P(O)(OT1495)(OT1496), -Si(T1497)(T1498)(T1499)"; where T1448, T1449, T1450, T1451, T1452, T1453, T1454, T1455, T1456, T1457, T1458, T1459, T1460, T1461, T1462, T1463, T1464, T1465,T1466, T1467, T1468, T1469, T1470, 15 T1471, T1472, T1473, T1474, T1475, T1476,T1477,T1478, T1479, T1480, T1481, T1482, T1483, T1484,T1485, T1486, T1487, T1488, T1489, T1490, T1491, T1492, T1493, T1494, T1495, T1496, T1497, T1498, T1499 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, 20 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1454, T1455 and/or T1463, T1464 and/or T1476, T1477 and/or T1483, T1484 and/or T1492, T1493, in each case together, may also form "heterocyclyl"; 25 where, optionally, the above substituents of substitution group (1) may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1 500, -NT1501T1 502, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Ti 503, -C(O)O T1504, -C(O)NH-T1505, -C(O)NT1506T1507, -O-T1508, - W02007/054556 PCTIEP2006/068322 -145 O(-T1 509-0),v-H (rv = 1, 2, 3, 4, 5), -O(-T1 510O-0)r,-T1 511 (rv = 1, 2, 3, 4, 5), -OC(O)-T1512, -OC(O)-O-T1 513, OC(O)-NHT1514, -O-C(O)-NT1515T1516, OP(O)(OT1 517)(OT1 518), -OSi(T1 519)(T1 520)(T1 521), 5 OS(O 2 )-T1 522, -NHC(O)-T1 523, -NT1 524C(O)-Ti 525, NH-C(O)-O-T1526, -NH-C(O)-NH-T1527, -NH-C(O) NT1 528T1 529, -NT1 530-C(O)-O-T1 531, -NT1 532-C(O) NH-T1533, -NT1534-C(O)-NT1535T1536, -NHS(0 2 )-T1537, -NT1 538S(0 2 )-T1 539, -S-T1540, -S(O)-T1 541, -S(0 2

)

10 T1542, -S(0 2 )NH-T1543, -S(0 2 )NT1544T1545, -S(0 2

)O

T1 546, -P(O)(OT1 547)(OT1 548), -Si(T1 549)(T1 550)(T1 551)"; where T1500, T1501, T1502, T1503, T1504, T1505, T1506, T1507, T1508, T1509, T15lO, Ti5li, T1512,T1513, T1514, T1515, T1516, T1517, T1518, T1519, T1520, T1521, T1522, 15 T1523, T1524, T1525, T1526, Ti527, T1528,T1529, T1530, T1531, T1532, T1533, T1534, T1535, T1536,T1537, T1538, T1539, T1540, T1541, T1542, Ti543, T1544,T1545, T1546, T1547, T1548, T1549, T1550, T1551 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, 20 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 506, T1507 and/or T1515, T1516 and/or T1528, T1 529 and/or T1 535, T1 536 and/or T1 544, T1 545, in each case together, may also form "heterocyclyl"; 25 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1552, -NT1553T1554,

-NO

2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1555, C(O)O-T1 556, -C(O)NH-Ti 557, -C(O)NT1 558T1 559, - W02007/054556 PCT/EP2006/068322 -146 O-T1560, -O(-T1561-0),-H (rw = 1, 2, 3, 4, 5), -O( T1 562-0),-T1 563 (rw = 1, 2, 3, 4, 5), -OC(O)-T1 564, OC(O)-O-T1565, -OC(O)-NHT1566, -0-C(O) NT1 567T1 568, -OP(O)(OT1 569)(OT1 570), 5 OSi(T1 571)(T1 572)(T1 573), -OS(0 2 )-T1 574, -NHC(O) T1 575, -NT1 576C(O)-T1 577, -NH-C(O)-O-T1 578, -NH C(O)-NH-Ti 579, -NH-C(O)-NT1 580T1 581, -NT1 582 C(O)-O-T1583, -NT1584-C(O)-NH-T1585, -NT1586 C(O)-NT1 587T1588, -NHS(0 2 )-T1 589, -NT1 590S(O 2

)

10 T1 591, -S-T1 592, -S(O)-Ti 593, -S(0 2 )-T1 594, S(0 2 )NH-Ti 595, -S(0 2 )NT1 596T1 597, -S(0 2 )O-T1 598, P(O)(OT1599)(OT1600), -Si(T1601)(T1602)(T1603)"; where T1552, T1553, T1554, T1555, T1556, T1557, T1558, T1559, T1560, T1561, T1562, T1563, T1564, 15 T1565, T1566, T1567, T1568, T1569, T1570, T1571, T1572, T1573, T1574,T1575, T1576, T1577, T1578, T1579, T1580, T1581,T1582, T1583, T1584, T1585, T1586, T1587, T1588,T1589, T1590, T1591, T1592, T1593, T1594, T1595,T1596, T1597,T1598, T1599, 20 T1600, T1601, T1602, T1603 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1558, T1559 and/or T1567, T1568 and/or 25 T1580, T1581 and/or T1587, T1588 and/or T1596, T1597, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently 30 from the group consisting of: (iii) "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , NHT1604, -NT1605T16O6, -NO 2 , -OH, -OCF 3 , -SH, - W02007/054556 PCT/EP2006/068322 - 147

O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , SO 3 H, -P(O)(OH) 2 , -C(O)-T1 607, -C(0)O-Ti 608, C(O)NH-T1609, -C(O)NT161OT1611, -O-T1612, -O( T1613-0),-H (rx = 1, 2, 3, 4, 5), -O(-T1614-0), 5 T1615 (rx = 1, 2, 3, 4, 5), -OC(O)-T1616, -OC(O)-O T1617, -OC(O)-NHT1618, -O-C(O)-NT1619T1620, OP(O)(OT1621)(OT1622), OSi(T1623)(T1624)(T1625), -OS(0 2 )-T1626, NHC(O)-T1627, -NT1628C(O)-T1629, -NH-C(O)-O 10 T1630, -NH-C(O)-NH-T1631, -NH-C(O) NT1 632T1633, -NT1 634-C(O)-O-T1635, -NT1636 C(O)-NH-T1637, -NT1638-C(O)-NT1639T1640, NHS(0 2 )-T1641, -NT1642S(O 2 )-T1643, -S-T1644, S(O)-T1645, -S(0 2 )-T1646, -S(0 2 )NH-T1647, 15 S(0 2 )NT1648T1649, -S(0 2 )O-T1650, P(O)(OT1651)(OT1652), -Si(T1653)(T1654)(T1655)"; where T1604, T1605, T1606, T1607, T1608, T1609, T1610, T1611, T1 612, T1613, T1614, T1615, T1616, T1617, T1618, T1619, T1620, T1621,T1622, T1623, 20 T1624, T1625,T1626, T1627, T1628,T1629, T1630, T1631, T1632, T1633, T1634, T1635, T1636, T1637, T1638, T1639, T1640, T1641, T1642, T1643, T1644, T1645, T1646, T1647, T1648, T1649, T1650, T1651, T1652, T1653, T1654, T1655 are each independently 25 selected from the group consisting of: "alkyl, (C

C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1610, T1611 and/or T1619, T1620 and/or T1 632, T1 633 and/or 30 T1 639, T1640 and/or T1648, T1649, in each case together, may also form "heterocyclyl"; where, alternatively, T1446, T1447 together may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -148 (3) "-C(Y8)NZ43Z44, -C(=NZ45)-Z46, -C(Y9)NZ47-Yl 0-Z48"; where Y8, Y9, Y10 are each independently selected from the group consisting of "0, S, =NH, =NZ49" where the Z43, Z44, Z45, Z46, Z47, Z48, Z49 radicals are each 5 independently selected from the group consisting of: (1) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O)-alkyl, -C(O)-(C-C 3 0 )alkyl, -C(O) cycloalkyl, -C(O)-cycloalkylalkyl, -C(O)-aryl, -C(O)-arylalkyl, 10 C(O)-heteroaryl, -C(O)-heteroarylalkyl, -C(O)-heterocyclyl, C(O)-heterocyclylalkyl, -S(0 2 )-alkyl, -S(0 2

)-(C-C

3 )alkyl, S(0 2 )-cycloalkyl, -S(0 2 )-cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2

)

arylalkyl, -S(0 2 )-heteroaryl, -S(0 2 )-heteroarylalkyl, -S(02) heterocyclyl, -S(02)-heterocyclylalkyl"; 15 where, optionally, the above substituents of substituent group (1) may also each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT1656, -NT1657T1658, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1659, -C(O)O T1660, -C(O)NH-T1661, -C(O)NT1662T1663, -O-T1664, 25 O(-T1665-O)y--H (ry = 1, 2, 3, 4, 5), -O(-T1666-)ry-T1667 (ry = 1, 2, 3, 4, 5), -OC(O)-T1668, -OC(O)-O-T1669, OC(O)-NHT1670, -O-C(O)-NT1671T1672, OP(O)(OT1 673)(OT1 674), -OSi(T1 675)(T1 676)(T1 677), OS(O 2 )-T1678, -NHC(O)-T1679, -NT1680C(O)-T1681, 30 NH-C(O)-O-T1682, -NH-C(O)-NH-T1683, -NH-C(O) NT1684T1685, -NT1686-C(O)-O-T1687, -NT1688-C(O) NH-T1689, -NT1690-C(O)-NT1691T1692, -NHS(0 2 )-T1693, -NT1694S(O 2 )-T1695, -S-T1696, -S(O)-T1697, -S(0 2

)-

W02007/054556 PCT/EP2006/068322 -149 T1 698, -S(0 2 )NH-T1 699, -S(0 2 )NT1 700T1 701, -S(02)O T1 702, -P(O)(OT1 703)(OT1 704), -Si(T1 705)(T1 706)(T1 707)"; where T1656, T1657, T1658, T1659, T1660, T1661, T1662, T1663,T1664, T1665, T1666, T1667, T1668, T1669, T1670, 5 T1671,T1672,T1673,T1674,T1675,T1676, T1677,T1678, T1679,T1680, T1681, T1682, T1683, T1684, T1685, T1686, T1687, T1688, T1689, T1690, T1691, T1692, T1693, T1694, T1695, T1696, T1697, T1698, T1699, T1700, T1701, T1702, T1 703, T1 704, T1 705, T1 706, T1 707 are each independently 10 selected from the group consisting of: "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1662, T1663 and/or T1671, T1672 and/or T1684, T1685 and/or T1691, T1692 and/or T1700, T1701, in each case 15 together, may also form 'heterocyclyl"; where, optionally, the above substituents of substituent group (i) may also in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 20 (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1 708, -NT1709T1710,

-NO

2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Ti 711, 25 C(O)O-T1712, -C(O)NH-T1713, -C(O)NT1714T1715, O-T1716, -O(-T1717-O)r-H (rz = 1, 2, 3, 4, 5), -O( T1718-O)r-T1719 (rz = 1, 2, 3, 4, 5), -OC(O)-T1720, OC(O)-O-T1721, -OC(O)-NHT1722, -0-C(O) NT1 723T1 724, -OP(O)(OT1 725)(OT1 726), 30 OSi(T1727)(T1728)(T1729), -OS(O 2 )-T1730, -NHC(O) T1 731, -NT1 732C(O)-Ti 733, -NH-C(O)-O-T1 734, -NH C(O)-NH-Ti 735, -NH-C(O)-NT1 736T1 737, -NT1 738 C(O)-O-T1 739, -NT1 740-C(O)-NH-Ti 741, -NT1 742 C(O)-NT1 743T1 744, -NHS(O 2 )-T1 745, -NT1 746S(O 2

)-

W02007/054556 PCT/EP2006/068322 -150 T1 747, -S-T1748, -S(O)-T1 749, -S(0 2 )-T1 750, S(O 2 )NH-T1 751, -S(0 2 )NT1 752T1 753, -S(0 2 )O-T1 754, P(O)(OT1 755)(OT1 756), -Si(T1 757)(T1 758)(T1 759)"; where T1708, T1709, T1710, T1711, T1712, T1713, 5 T1714, T1715, T1716, T1717,T1718,T1719,T1720, T1721, T1722, T1723, T1724,T1725,T1726,T1727, T1728, Ti729, T1730, T1731, T1732, T1733, T1734, T1735, Ti736, Ti737, T1738, T1739,T1740,T1741, T1742, T1743, T1744, Ti745, Ti746,Ti747, T1748, 10 T1749, T1750, T1751, T1752, T1753,Ti754,T1755, T1 756, T1 757, T1758, T1 759 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, 15 alternatively, T1714, T1715 and/or T1723, T1724 and/or T1736, T1 737 and/or T1743, T1744 and/or TI752, T1 753, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by 20 at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , 25 NHT1760, -NT1761T1762, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , SO 3 H, -P(O)(OH) 2 , -C(O)-Ti 763, -C(O)O-Ti 764, C(O)NH-T1765, -C(O)NT1766T1767, -0-T1768, -O( T1769-0)ra-H (ra = 1, 2, 3, 4, 5), -O(-T1770-0), 30 T1 771 (ra = 1, 2, 3, 4, 5), -OC(O)-Ti 772, -OC(O)-O T1 773, -OC(O)-NHT1 774, -0-C(O)-NT1 775T1 776, OP(O)(OT1777)(OT1778), OSi(T1 779)(T1 780)(T1 781), -OS(O 2 )-T1 782, NHC(O)-T1783, -NT1784C(O)-T1785, -NH-C(O)-O- W02007/054556 PCT/EP2006/068322 -151 T1786, -NH-C(O)-NH-T1787, -NH-C(O) NT1788T1789, -NT1790-C(O)-O-T1791, -NT1792 C(O)-NH-Ti 793, -NT1794-C(O)-NT1 795T1 796, NHS(0 2 )-T1 797, -NT1 798S(0 2 )-T1 799, -S-T1 800, 5 S(O)-T1801, -S(0 2 )-T1802, -S(0 2 )NH-T1803, S(0 2 )NT1804T1805, -S(0 2 )O-T1806, P(O)(OT1 807)(OT1 808), -Si(T1 809)(T1 81 0)(T1 811)"; where T1760, T1761, T1 762, T1763, T1764, T1 765, T1766,Ti767, T1768, Ti769, T1770, T1771, Ti772, 10 T1773, Ti774, Ti775, T1776, T1777, T1778, T1779, T1780, T1781, T1782, T1783, Ti784, T1785, T1786, T1787,Ti788, Ti789, T1790, T1791, T1792,Ti793, T1794, T1795, T1796, T1797, Ti798, T1799,T1800, T1801,Ti802, T1803, T1804,T1805, T1806, T1807, 15 T1808, T1809, T1810, T1811 are each independently selected from the group consisting of: "alkyl, (C9

C

3 o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1766, T1767 20 and/or T1775, T1776 and/or T1788, T1789 and/or T1795, T1 796 and/or T1 804, T1 805, in each case together, may also form "heterocyclyl"; and 25 the Z3, Z4 radicals are each independently selected from the group consisting of: (e) hydrogen; (f) halogen, F, Cl, Br, I; 30 (g) unsubstituted or substituted alkyl or (C 9

-C

30 )alkyl, where, optionally, the alkyl or (C 9

-C

30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 - 152 (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB457, -NB458B459, -NO 2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 5 P(O)(OH) 2 , -C(O)-B460, -C(O)O-B461, -C(O)NH-B462, C(O)NB463B464, -O-B465, -O(-B466-O),-H (x = 1, 2, 3, 4, 5), -O( B467-0),-B468 (x = 1, 2, 3, 4, 5), -OC(O)-B469, -OC(O)-O-B470, OC(O)-NHB471, -O-C(O)-NB472B473, -OP(O)(OB474)(OB475), OSi(B476)(B477)(B478), -OS(0 2 )-B479, -NHC(O)-B480, 10 NB481C(O)-B482, -NH-C(O)-O-B483, -NH-C(O)-NH-B484, -NH C(O)-NB485B486, -NB487-C(O)-O-B488, -NB489-C(O)-NH B490, -NB491-C(O)-NB492B493, -NHS(O 2 )-B494, -NB495S(0 2

)

B496, -S-B497, -S(O)-B498, -S(O 2 )-B499, -S(0 2 )NH-B500, S(0 2 )NB501 B502, -S(0 2 )O-B503, -P(O)(OB504)(OB505), 15 Si(B506)(B507)(B508)"; where B457, B458, B459, B460, B461, B462, B463, B464, B465, B466, B467, B468, B469, B470, B471, B472, B473, B474, B475, B476, B477, B478, B479, B480, B481, B482, B483, B484, B485, B486, B487, B488, B489, B490, B491, B492, B493, B494, B495, 20 B496, B497, B498, B499, B500, B501, B502, B503, B504, B505, B506, B507, B508 are each independently selected from the group consisting of: "alkyl, (COg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B463, B464 and/or B472, 25 B473 and/or B485, B486 and/or B492, B493 and/or B501, B502, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 30 (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB509, -NB51OB511, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-B512, -C(O)O-B513, -C(O)NH- W02007/054556 PCT/EP2006/068322 -153 B514, -C(O)NB515B516, -O-B517, -O(-B518-0)y-H (y = 1, 2, 3, 4, 5), -O(-B519-O)y-B520 (y = 1, 2, 3, 4, 5), -OC(O)-B521, OC(O)-O-B522, -OC(O)-NHB523, -O-C(O)-NB524B525, OP(O)(OB526)(OB527), -OSi(B528)(B529)(B530), -OS(0 2

)

5 B531, -NHC(O)-B532, -NB533C(O)-B534, -NH-C(O)-O-B535, -NH-C(O)-NH-B536, -NH-C(O)-NB537B538, -NB539-C(O)-O B540, -NB541-C(O)-NH-B542, -NB543-C(O)-NB544B545, NHS(0 2 )-B546, -NB547S(0 2 )-B548, -S-B549, -S(O)-B550, S(0 2 )-B551, -S(0 2 )NH-B552, -S(0 2 )NB553B554, -S(0 2

)O

10 B555, -P(O)(OB556)(OB557), -Si(B558)(B559)(B560)"; where B509, B510, B511, B512, B513, B514, B515, B516, B517, B518, B519, B520, B521, B522, B523, B524, B525, B526, B527, B528, B529, B530, B531, B532, B533, B534, B535, B536, B537, B538, B539, B540, B541, B542, B543, B544, B545, B546, B547, 15 B548, B549, B550, B551, B552, B553, B554, B555, B556, B557, B558, B559, B560 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B515, B516 and/or B524, 20 B525 and/or B537, B538 and/or B544, B545 and/or B553, B554, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 25 consisting of: (iii) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHB561, -NB562B563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 30 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B564, -C(O)O-B565, C(O)NH-B566, -C(O)NB567B568, -O-B569, -O(-B570-0)z H (z = 1, 2, 3, 4, 5), -O(-B571-O)z-B572 (z = 1, 2, 3, 4, 5), OC(O)-B573, -OC(O)-O-B574, -OC(O)-NHB575, -0-C(O) NB576B577, -OP(O)(OB578)(OB579), - W02007/054556 PCT/EP2006/068322 -154 OSi(B580)(B581)(B582), -OS(0 2 )-B583, -NHC(O)-B584, NB585C(O)-B586, -NH-C(O)-O-B587, -NH-C(O)-NH B588, -NH-C(O)-NB589B590, -NB591-C(O)-O-B592, NB593-C(O)-NH-B594, -NB595-C(O)-NB596B597, 5 NHS(0 2 )-B598, -NB599S(O 2 )-B600, -S-B601, -S(O)-B602, -S(0 2 )-B603, -S(0 2 )NH-B604, -S(0 2 )NB605B606, -S(0 2

)O

B607, -P(O)(OB608)(OB609), -Si(B61 0)(B61 1)(B612)"; where B561, B562, B563, B564, B565, B566, B567, B568, B569, B570, B571, B572, B573, B574, B575, B576, B577, 10 B578, B579, B580, B581, B582, B583, B584, B585, B586, B587, B588, B589, B590, B591, B592, B593, B594, B595, B596, B597, B598, B599, B600, B601, B602, B603, B604, B605, B606, B607, B608, B609, B610, B611, B612 are each independently selected from the group consisting of: "alkyl, 15 (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B567, B568 and/or B576, B577 and/or B589, B590 and/or B596, B597 and/or B605, B606, in each case together, may also form "heterocyclyl"; 20 (h) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB613, -NB614B615, -NO 2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-B616, -C(O)O-B617, -C(O)NH-B618, C(O)NB619B620, -0-B621, -0(-B622-0)a-H (a = 1, 2, 3, 4, 5), -O( 30 B623-0)a-B624 (a = 1, 2, 3, 4, 5), -OC(O)-B625, -OC(O)-O-B626, OC(O)-NHB627, -O-C(O)-NB628B629, -OP(O)(OB630)(OB631), OSi(B632)(B633)(B634), -OS(0 2 )-B635, -NHC(O)-B636, NB637C(O)-B638, -NH-C(O)-O-B639, -NH-C(O)-NH-B640, -NH- W02007/054556 PCT/EP2006/068322 - 155 C(O)-NB641B642, -NB643-C(O)-O-B644, -NB645-C(O)-NH B646, -NB647-C(O)-NB648B649, -NHS(0 2 )-B650, -NB651 S(0 2

)

B652, -S-B653, -S(O)-B654, -S(0 2 )-B655, -S(0 2 )NH-B656, S(0 2 )NB657B658, -S(0 2 )O-B659, -P(O)(OB660)(OB661), 5 Si(B662)(8663)(B664)"; where B613, B614, B615, B616, B617, B618, B619, B620, B621, B622, B623, B624, B625, B626, B627, B628, B629, B630, B631, B632, B633, B634, B635, B636, B637, B638, B639, B640, B641, B642, B643, B644, B645, B646, B647, B648, B649, B650, B651, 10 B652, B653, B654, B655, B656, B657, B658, B659, B660, B661, B662, B663, B664 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B619, B620 and/or B628, 15 B629 and/or B641, B642 and/or B648, B649 and/or B657, B658, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 20 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB665, -NB666B667, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-B668, -C(O)O-B669, -C(O)NH 25 B670, -C(O)NB671B672, -O-B673, -O(-B674-O)b-H (b = 1, 2, 3, 4, 5), -O(-B675-O)b-B676 (b = 1, 2, 3, 4, 5), -OC(O)-B677, OC(O)-O-B678, -OC(O)-NHB679, -O-C(O)-NB680B681, OP(O)(OB682)(OB683), -OSi(B684)(B685)(B686), -OS(0 2

)

B687, -NHC(O)-B688, -NB689C(O)-B690, -NH-C(O)-O-B691, 30 -NH-C(O)-NH-B692, -NH-C(O)-NB693B694, -NB695-C(O)-O B696, -NB697-C(O)-NH-B698, -NB699-C(O)-NB700B701, NHS(0 2 )-B702, -NB703S(0 2 )-B704, -S-B705, -S(O)-B706, S(0 2 )-B707, -S(0 2 )NH-B708, -S(0 2 )NB709B710, -S(0 2

)O

B71 1, -P(O)(OB712)(OB713), -Si(B714)(B715)(B716)"; W02007/054556 PCT/EP2006/068322 - 156 where B665, B666, B667, B668, B669, B670, B671, B672, B673, B674, B675, B676, B677, B678, B679, B680, B681, B682, B683, B684, B685, B686, B687, B688, B689, B690, B691, B692, B693, B694, B695, B696, B697, B698, B699, B700, B701, B702, B703, 5 B704, B705, B706, B707, B708, B709, B710, B711, B712, B713, B714, B715, B716 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B671, B672 and/or B680, 10 B681 and/or B693, B694 and/or B700, B701 and/or B709, B710, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 15 consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB717, -NB718B719, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 20 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B720, -C(O)O-B721, C(O)NH-B722, -C(O)NB723B724, -0-B725, -O(-B726-0)c H (c = 1, 2, 3, 4, 5), -O(-B727-O)c-B728 (c = 1, 2, 3, 4, 5), OC(O)-B729, -OC(O)-O-B730, -OC(O)-NHB731, -O-C(O) NB732B733, -OP(O)(OB734)(OB735), 25 OSi(B736)(B737)(B738), -OS(O 2 )-B739, -NHC(O)-B740, N B741 C(O)-B742, -N H-C(O)-O-B743, -N H-C(O)-N H B744, -NH-C(O)-NB745B746, -NB747-C(O)-O-B748, NB749-C(O)-NH-B750, -NB751-C(O)-NB7528753, NHS(0 2 )-B754, -NB755S(0 2 )-B756, -S-B757, -S(O)-B758, 30 -S(0 2 )-B759, -S(0 2 )NH-B760, -S(0 2 )NB761 B762, -S(0 2

)O

B763, -P(O)(OB764)(OB765), -Si(B766)(B767)(B768)"; where B717, B718, B719, B720, B721, B722, B723, B724, B725, B726, B727, B728, B729, B730, B731, B732, B733, B734, B735, B736, B737, B738, B739, B740,B741, B742, W02007/054556 PCT/EP2006/068322 - 157 B743, B744', B745, B746, B747, B748, B749, B750, B751, B752, B753, B754, B755, B756, B757, B758, B759, B760, B761, B762, B763, B764, B765, B766, B767, B768 are each independently selected from the group consisting of: "alkyl, 5 (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B723, B724 and/or B732, B733 and/or B745, B746 and/or B752, B753 and/or B761, B762, in each case together, may also form "heterocyclyl"; 10 (j) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB769, -NB770B771, -NO 2 , -OH, -OCF 3 , -SH,

-O-SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-B772, -C(O)O-B773, -C(O)NH-B774, C(O)NB775B776, -O-B777, -O(-B778-O),-H (d = 1, 2, 3, 4, 5), -O( 20 B779-O)d-B780 (d = 1, 2, 3, 4, 5), -OC(O)-B781, -OC(O)-O-B782, OC(O)-NHB783, -O-C(O)-NB784B785, -OP(O)(OB786)(OB787), OSi(B788)(B789)(B790), -OS(0 2 )-B791, -NHC(O)-B792, NB793C(O)-B794, -NH-C(O)-O-B795, -NH-C(O)-NH-B796, -NH C(O)-NB797B798, -NB799-C(O)-O-B800, -NB801-C(O)-NH 25 B802, -NB803-C(O)-NB804B805, -NHS(0 2 )-B806, -NB807S(0 2

)

B808, -S-B809, -S(O)-B810, -S(0 2 )-B811, -S(0 2 )NH-B812, S(0 2 )NB813B814, -S(0 2 )O-B815, -P(O)(OB816)(OB817), Si(B818)(B819)(B820)"; where B769, B770, B771, B772, B773, B774, B775, B776, B777, 30 B778, B779, B780, B781, B782, B783, B784, B785, B786, B787, B788, B789, B790, B791, B792, B793, B794, B795, B796, B797, B798, B799, B800, B801, B802, B803, B804, B805, B806, B807, B808, B809, B810, B811, B812, B813, B814, B815, B816, B817, W02007/054556 PCT/EP2006/068322 - 158 B818, B819, B820 are each independently selected from the group consisting of: "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B775, B776 and/or B784, 5 B785 and/or B797, B798 and/or B804, B805 and/or B813, B814, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB821, -NB822B823, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH) 2 , -C(O)-B824, -C(O)O-B825, -C(O)NH 15 B826, -C(O)NB827B828, -0-B829, -O(-B830-0)e-H (e = 1, 2, 3, 4, 5), -0(-B831-O)e-B832 (e = 1, 2, 3, 4, 5), -OC(O)-B833, OC(O)-O-B834, -OC(O)-NHB835, -O-C(O)-NB836B837, OP(O)(OB838)(OB839), -OSi(B840)(B841)(B842), -OS(0 2

)

B843, -NHC(O)-B844, -NB845C(O)-B846, -NH-C(O)-O-B847, 20 -NH-C(O)-NH-B848, -NH-C(O)-NB849B850, -NB851-C(O)-O B852, -NB853-C(O)-NH-B854, -NB855-C(O)-NB856B857, NHS(0 2 )-B858, -NB859S(0 2 )-B860, -S-B861, -S(O)-B862, S(0 2 )-B863, -S(0 2 )NH-B864, -S(0 2 )NB865B866, -S(0 2

)O

B867, -P(O)(OB868)(OB869), -Si(B870)(B871)(B872)"; 25 where B821, B822, B823, B824, B825, B826, B827, B828, B829, B830, B831, B832, B833, B834, B835, B836, B837, B838, B839, B840, B841, B842, B843, B844, B845, B846, B847, B848, B849, B850, B851, B852, B853, B854, B855, B856, B857, B858, B859, B860, B861, B862, B863, B864, B865, B866, B867, B868, B869, 30 B870, B871, B872 are each independently selected from the group consisting of: "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B827, B828 and/or B836, W02007/054556 PCT/EP2006/068322 -159 B837 and/or B849, B850 and/or B856, B857 and/or B865, B866, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 5 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB873, -NB874B875, -NO 2 , 10 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(0)-B876, -C(O)O-B877, C(O)NH-B878, -C(O)NB879B880, -O-1B881, -O(-B882-O)r H (f = 1, 2, 3, 4, 5), -O(-B883-O)r-B884 (f = 1, 2, 3, 4, 5), OC(O)-B885, -OC(O)-O-B886, -OC(O)-NHB887, -0-C(O) 15 NB888B889, -OP(O)(OB890)(OB891), OSi(B892)(B893)(B894), -OS(0 2 )-B895, -NHC(O)-B896, NB897C(O)-B898, -NH-C(O)-O-B899, -NH-C(O)-NH B900, -NH-C(O)-NB901B902, -NB903-C(O)-O-B904, NB905-C(O)-NH-B906, -NB907-C(O)-NB908B909, 20 NHS(0 2 )-B910, -NB91 1S(0 2 )-B912, -S-B913, -S(O)-B914, -S(0 2 )-B915, -S(0 2 )NH-B916, -S(0 2 )NB917B918, -S(0 2

)O

B919, -P(O)(OB920)(OB921), -Si(B922)(B923)(B924)"; where B873, B874, B875, B876, B877, B878, B879, B880, B881, B882, B883, B884, B885, B886, B887, B888, B889, 25 B890, B891, B892, B893, B894, B895, B896, B897, B898, B899, B900, B901, B902, B903, B904, B905, B906, B907, B908, B909, B910, B911, B912, B913, B914, B915, B916, B917, B918, B919, B920, B921, B922, B923, B924 are each independently selected from the group consisting of: "alkyl, 30 (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B879, B880 and/or B888, B889 and/or B901, B902 and/or B908, B909 and/or B917, B918, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 160 (k) OZ6 where Z6 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 5 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 10 Br, I, CN, CF 3 , N 3 , NH 2 , -NHB925, -NB926B927, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 ,

-SO

3 H, -P(O)(OH)2, -C(O)-B928, -C(O)O-B929, -C(O)NH B930, -C(O)NB931B932, -O-B933, -O(-B934-O)g-H (g = 1, 2, 3, 4, 5), -O(-B935-O)g-B936 (g = 1, 2, 3, 4, 5), -OC(O)-B937, 15 OC(O)-O-B938, -OC(O)-NHB939, -O-C(O)-NB940B941, OP(O)(OB942)(OB943), -OSi(B944)(B945)(B946), -OS(0 2

)

B947, -NHC(O)-B948, -NB949C(O)-B950, -NH-C(O)-O-B951, -NH-C(O)-NH-B952, -NH-C(O)-NB953B954, -NB955-C(O)-O B956, -NB957-C(O)-NH-B958, -NB959-C(O)-NB960B961, 20 NHS(0 2 )-B962, -NB963S(0 2 )-B964, -S-B965, -S(O)-B966, S(0 2 )-B967, -S(0 2 )NH-B968, -S(0 2 )NB969B970, -S(0 2

)O

B971, -P(O)(OB972)(OB973), -Si(B974)(B975)(B976)"; where B925, B926, B927, B928, B929, B930, B931, B932, B933, B934, B935, B936, B937, B938, B939, B940, B941, B942, B943, 25 B944, B945, B946, B947, B948, B949, B950, B951, B952, B953, B954, B955, B956, B957, B958, B959, B960, B961, B962, B963, B964,B965, B966, B967, B968, B969,B970, B971, B972, B973, B974, B975, B976 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, 30 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B931, B932 and/or B940, B941 and/or B953, B954 and/or B960, B961 and/or B969, B970, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -161 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHB977, -NB978B979, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B980, -C(O)O-B981, 10 C(O)NH-B982, -C(O)NB983B984, -0-8985, -0(-B986-O)h H (h = 1, 2, 3, 4, 5), -O(-B987-O)h-B988 (h = 1, 2, 3, 4, 5), OC(O)-B989, -OC(O)-O-B990, -OC(O)-NHB991, -0-C(O) NB992B993, -OP(O)(OB994)(OB995), OSi(B996)(B997)(B998), -OS(0 2 )-B999, -NHC(O)-B1000, 15 NB1001C(O)-B1002, -NH-C(O)-O-B1003, -NH-C(O)-NH B1004, -NH-C(O)-NB1005B1006, -NB1007-C(O)-O-B1008, -NB1009-C(O)-NH-B1010, -NB1011-C(O)-NB1012B1013, NHS(0 2 )-B1014, -NB1015S(O 2 )-B1016, -S-B1017, -S(O) B1018, -S(0 2 )-B1019, -S(0 2 )NH-B1020, 20 S(0 2 )NB1 021 B1022, -S(0 2 )O-B1023, P(O)(OB1024)(OB1025), -Si(B1 026)(B1 027)(B1 028)"; where B977, B978, B979, B980, B981, B982, B983, B984, B985, B986, B987, 8988, B989, B990, B991, B992, B993, B994, B995, B996, B997, B998, B999, B1000, B1001, B1002, 25 B1003, B1004, B1005, B1006, B1007, B1008, B1009, B1010, B1011, B1012, B1013, B1014, B1015, B1016, B1017, B1018, B1019, B1020, B1021, B1022, B1023, B1024, B1025, B1026, B1027, B1028 are each independently selected from the group consisting of: "alkyl, (C9-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, 30 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B983, B984 and/or B992, B993 and/or 81005, B1006 and/or 81012, B1013 and/or B1021, B1022, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 162 (1) SZ7 where Z7 is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 5 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 10 Br, I, CN, CF 3 , N 3 , NH 2 , -NHB1029, -NB1030B1031, -NO 2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B1032, -C(O)O-B1033, C(O)NH-B1 034, -C(O)NB1 035B1036, -0-B1037, -O(-B1 038 O)-H (i = 1, 2, 3, 4, 5), -O(-B1039-0),-B1040 (i = 1, 2, 3, 4, 5), 15 OC(O)-B1041, -OC(O)-O-B1042, -OC(O)-NHB1043, -0-C(O) NB1044B1045, -OP(O)(OB1046)(0B1047), OSi(B1048)(B1049)(B1050), -OS(O 2 )-B1051, -NHC(O)-B1052, NB1053C(O)-B1054, -NH-C(O)-O-B1055, -NH-C(O)-NH B1056, -NH-C(O)-NB1057B1058, -NB1059-C(O)-O-B1060, 20 NB1061-C(O)-NH-B1062, -NB1063-C(O)-NB1064B1065, NHS(0 2 )-B1 066, -NB1 067S(0 2 )-B1 068, -S-B1 069, -S(O) B1070, -S(O 2 )-B1071, -S(0 2 )NH-B1072, -S(0 2 )NB1073B1074, S(0 2 )O-B1075, -P(O)(OB1076)(OB1077), Si(B1 078)(B1 079)(B1 080)"; 25 where B1029, B1030, B1031, B1032, B1033, B1034, B1035, B1036, B1037, B1038, B1039, B1040, B1041, B1042, B1043, B1044, B1045, B1046, B1047, B1048, B1049, B1050, B1051, B1052, B1053, B1054, B1055, B1056, B1057, B1058, B1059, B1060, B1061, B1062, B1063, B1064, B1065, B1066, B1067, 30 B1068, B1069, B1070, B1071, B1072, B1073, B1074, B1075, B1076, B1077, B1078, B1079, B1080 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, W02007/054556 PCT/EP2006/068322 -163 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1035, B1036 and/or B1044, B1045 and/or B1057, B1058 and/or B1064, B1065 and/or B1073, B1074, in each case together, may also form "heterocyclyl"; 5 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB1081, -NB1082B1083, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B1084, -C(O)O B1085, -C(O)NH-B1086, -C(O)NB1087B1088, -O-B1089, 15 O(-B1090-0);-H (j = 1, 2, 3, 4, 5), -O(-B1091-0);B1092 (j = 1, 2, 3, 4, 5), -OC(O)-B1 093, -OC(O)-O-B1094, -OC(O) NHB1095, -O-C(O)-NB1096B1097, OP(O)(OB1098)(OB1099), -OSi(B1100)(B1 101)(B1102), OS(0 2 )-B1 103, -NHC(O)-B1 104, -NB1 105C(O)-B1 106, 20 NH-C(O)-O-B1 107, -NH-C(O)-NH-B1 108, -NH-C(O) NB1109B1110, -NB111-C(O)-O-B1112, -NB1113-C(O) NH-B1114, -NB1115-C(O)-NB1116B1117, -NHS( 2

)

B1118, -NB1119S(0 2 )-B1120, -S-B1121, -S(O)-B1122, S(0 2 )-B1123, -S(0 2 )NH-B1124, -S(0 2 )NB1125B1126, 25 S(0 2 )O-B1 127, -P(O)(OB1 128)(0B1129), Si(B1 130)(B1131)(B1132)"; where B1081, B1082, B1083, B1084, B1085, B1086, B1087, B1088, B1089, B1090, B1091, B1092, B1093, B1094, B1095, B1096, B1097, B1098, B1099, B1100, B1101, B1102, B1103, 30 B1104, B1105,B1106, B1107, B1108, B1109, B1110, B1111, B1112, B1113, B1114, B1115, B1116, B1117, B1118, B1119, B1120, B1121, B1122, 81123, B1124, B1125, B1126, B1127, B1128, B1129, B1130, 81131, B1132 are each independently selected from the group consisting of: "alkyl, (Cg-C 3 0 )alkyl, W02007/054556 PCT/EP2006/068322 -164 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1087, B1088 and/or B1096, B1097 and/or B1 109, B1110 and/or B1116, B1117 and/or B1125, B1126, in each case 5 together, may also form "heterocyclyl"; (m) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) B1133, -C(O)O-B1134, -C(O)-NB1135B1136, -S(0 2 )-B1137, S(0 2 )O-B1 138"; where B1133, B1134, B1135, B1136, B1137, B1138 are each independently selected from the group consisting of: hydrogen, alkyl, 15 (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1 135, B1136 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 20 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB1139, -NB1140B1141, -NO 2 , -OH,

-OCF

3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 25 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B1142, -C(O)O-B1143, C(O)NH-B1 144, -C(O)NB1 145B1146, -0-B1 147, -O(-B1 148 O)k-H (k = 1, 2, 3, 4, 5), -O(-B1149-O)k-B1150 (k = 1, 2, 3, 4, 5), -OC(O)-B1 151, -OC(O)-O-B1 152, -OC(O)-NHB1 153, -0 C(O)-NB 154B1155, -OP(O)(OB1 156)(OB1157), 30 OSi(B1 158)(B1159)(B1160), -OS(0 2 )-B1 161, -NHC(O)-B1 162, NB1 163C(O)-B1 164, -NH-C(O)-O-B1 165, -NH-C(O)-NH B1166, -NH-C(O)-NB1167B1168, -NB1169-C(O)-O-B1170, NB1171-C(O)-NH-B1172, -NB1173-C(O)-NB1174B1175, - W02007/054556 PCT/EP2006/068322 -165 NHS(0 2 )-B1 176, -NB1 177S(0 2 )-B1178, -S-B1 179, -S(O) B1 180, -S(0 2 )-B1 181, -S(0 2 )NH-B1 182, -S(0 2 )NB1 183B1184, S(0 2 )O-B1 185, -P(O)(OB1 186)(OB1187), Si(B1 188)(B1189)(B1190)"; 5 where B1139, B1140, B1141, B1142, B1143, B1144, B1145, B1146, B1147, B1148, B1149, Bl5O, Bl51, B1152, B1153, B1154, Bl155, B1156, B1157, B1158, B1159, B1160, B1161, B1162, B1163, B1164, B1165, B1166, B1167, B1168, B1169, B1170, B1171, B1172, B1173, B1174, B1175, B1176, B1177, 10 B1178,B1179,B1180,B1181,B1182,B1183,B1184,B1185, B1186, B1187, B1188, B1189, B1190 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 15 B1145, B1146 and/or B1154, B1155 and/or B1167, B1168 and/or B1 174, B1 175 and/or B1 183, B1 184, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 20 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB1191, -NB1192B1193, -NO 2 , 25 -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH,

-C(O)NH

2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B1194, -C(0)0 B1195, -C(O)NH-B1196, -C(O)NB1197B1198, -O-B1199, O(-B1200-0)r-H (I = 1, 2, 3, 4, 5), -O(-B1201-O)r-B1202 (1= 1, 2, 3, 4, 5), -OC(O)-B1203, -OC(O)-O-B1204, -OC(O) 30 NHB1205, -O-C(O)-NB1206B1207, OP(O)(OB1208)(OB1209), -OSi(B1210)(B1211)(B1212), OS(0 2 )-B1213, -NHC(O)-B1214, -NB1215C(O)-B1216, NH-C(O)-O-B1217, -NH-C(O)-NH-B1218, -NH-C(O) NB1219B1220, -NB1221-C(O)-O-B1222, -NB1223-C(O)- W02007/054556 PCT/EP2006/068322 -166 NH-B1 224, -NB1225-C(O)-NB1226B1227, -NHS(0 2

)

B1228, -NB1229S(0 2 )-B1230, -S-B1231, -S(O)-B1232, S(0 2 )-B1233, -S(0 2 )NH-B1234, -S(O 2 )NB1235B1 236, S(0 2 )O-B1237, -P(O)(OB1238)(OB1239), 5 Si(B1240)(B1241)(B1242)"; where B1191, B1192, B1193, B1194, B1195, B1196, 81197, 81198, B1199, 81200, B1201, 81202, B1203, B1204, B1205, B1206, 81207, B1208, B1209, B1210, B1211, B1212, B1213, B1214, B1215, B1216, B1217, B1218, B1219, B1220, B1221, 10 B1222, B1223, B1224, B1225, B1226, B1227, B1228, B1229, B1230, B1231, B1232, B1233, B1234, B1235, B1236, B1237, B1238, B1239, B1240, B1241, B1242 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 15 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 81197, B1198 and/or B1206, B1207 and/or B1219, B1220 and/or B1226, B1227 and/or B1235, B1236, in each case together, may also form "heterocyclyl"; 20 and the Z5 radical is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, 25 CF 3 , N 3 , NH 2 , -NHD1, -ND2D3, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-D4, C(0)O-D5, -C(O)NH-D6, -C(O)ND7D8, -O-D9, -O(-D1O-O)r-H (r = 1, 2, 3, 4, 5), -0(-D11-O)r-D12 (r = 1, 2, 3, 4, 5), -OC(O)-D13, -OC(O)-O-D14, OC(O)-NHD15, -O-C(O)-ND16D17, -OP(O)(OD18)(0D19), 30 OSi(D20)(D21)(D22), -OS(0 2 )-D23, -NHC(O)-D24, -ND25C(O)-D26, -NH C(O)-O-D27, -NH-C(O)-NH-D28, -NH-C(O)-ND29D30, -ND31-C(O)-O D32, -ND33-C(O)-NH-D34, -ND35-C(O)-ND36D37, -NHS(0 2 )-D38, - W02007/054556 PCT/EP2006/068322 - 167 ND39S(0 2 )-D40, -S-D41, -S(O)-D42, -S(0 2 )-D43, -S(0 2 )NH-D44, S(0 2 )ND45D46, -S(0 2 )0-D47, -P(O)(OD48)(OD49), -Si(D50)(D51)(D52)"; where D1, D2, D3, D4, D5, D6, D7, D8, D9, D10, D11, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, 5 D30, D31, D32, D33, D34, D35, D36, D37, D38, D39, D40, D41, D42, D43, D44, D45, D46, D47, D48, D49, D50, D51, D52 are each independently selected from the group consisting of: "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, D7, D8 and/or D16, D17 and/or D29, 10 D30 and/or D36, D37 and/or D45, D46, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (ii) "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHD53, -ND54D55, -NO 2 , -OH, -OCF 3 , -SH, -0

SO

3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-D56, -C(O)O-D57, -C(0)NH-D58, -C(O)ND59D60, -0-D61, -O( 20 D62-0),-H (s = 1, 2, 3, 4, 5), -O(-D63-0)t-D64 (t = 1, 2, 3, 4, 5), OC(O)-D65, -OC(O)-O-D66, -OC(O)-NHD67, -0-C(O)-ND68D69, OP(O)(OD70)(OD71), -OSi(D72)(D73)(D74), -OS(0 2 )-D75, -NHC(O) D76, -ND77C(O)-D78, -NH-C(O)-O-D79, -NH-C(O)-NH-D80, -NH C(O)-ND81D82, -ND83-C(O)-O-D84, -ND85-C(O)-NH-D86, -ND87 25 C(O)-ND88D89, -NHS(0 2 )-D90, -ND91S(0 2 )-D92, -S-D93, -S(O) D94, -S(0 2 )-D95, -S(0 2 )NH-D96, -S(0 2 )ND97D98, -S(0 2 )0-D99, P(O)(OD100)(OD101), -Si(D102)(D103)(D104)"; where D53, D54, D55, D56, D57, D58, D59, D60, D61, D62, D63, D64, D65, D66, D67, D68, D69, D70, D71, D72, D73, D74, 075, D76, D77, 30 D78, D79, D80, D81, D82, D83, D84, D85, D86, D87, D88, D89, D90, D91, D92, D93, D94, D95, D96, D97, D98, D99, D100, D101, D102, D103, D104 are each independently selected from the group consisting of: "alkyl, (C 9

-C

30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, W02007/054556 PCT/EP2006/068322 - 168 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, D59, D60 and/or D68, D69 and/or D81, D82 and/or D88, D89 and/or D97, D98, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in 5 turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9

-C

3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHD105, -ND106D107, -NO 2 , -OH, -OCF 3 , -SH, 10 -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-D1 08, -C(O)O-D1 09, -C(O)NH-D1 10, C(O)ND1 11 D112, -O-D1 13, -O(-D1 14-0)t-H (t = 1, 2, 3, 4, 5), -O( D1 15-O)t-D1 16 (t = 1, 2, 3, 4, 5), -OC(O)-D1 17, -OC(O)-O-D1 18, OC(O)-NHD1 19, -O-C(O)-ND12OD121, -OP(O)(OD122)(OD123), 15 OSi(D124)(D125)(D126), -OS(0 2 )-D127, -NHC(O)-D128, ND1 29C(O)-D1 30, -NH-C(O)-O-D1 31, -NH-C(O)-NH-D1 32, -NH C(O)-ND133D134, -ND135-C(O)-O-D136, -ND137-C(O)-NH D138, -ND139-C(O)-ND140D141, -NHS(0 2 )-D142, -ND143S(0 2

)

D144, -S-D145, -S(O)-D146, -S(0 2 )-D147, -S(0 2 )NH-D148, 20 S(0 2 )ND1 49D150, -S(0 2 )O-D1 51, -P(O)(OD1 52)(OD1 53), Si(D154)(D1 55)(D1 56)"; where D105, D106, D107, D108, D109, D110, D111, D112, D113, D114, D115, D116, D117, D118, D119, D120, D121, D122, D123, D124, D125, D126, D127, D128, D129, D130, D131, D132, D133, 25 D134, D135, D136, D137, D138, D139, D140, D141, D142, D143, D144, D145, D146, D147, D148, D149, D150, D151, D152, D153, D154, D155, D156 are each independently selected from the group consisting of: "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 30 heteroarylalkyl" and where, alternatively, D111, D112 and/or D120, D121 and/or D133, D134 and/or D140, D141 and/or D149, D150, in each case together, may also form "heterocyclyl".

W02007/054556 PCT/EP2006/068322 - 169 In order to avoid ambiguities, the cases (A) to (E) detailed above for the general formula (1) are explained below: In case (A), the novel pyrido[2,3-b]pyrazine derivatives may be substituted by "substituted aryl" in at least one of their Z3, Z4 radicals, the novelty arising either by 5 virtue of sub-case (a) or by virtue of sub-case (c). If only one Z3, Z4 radical is novel "substituted aryl", the other Z3, Z4 radical in each case may have any substitution within the maximum range stated [("and" linkage in subcase (d)]. Optionally, both Z3, Z4 radicals may also have further substitution [sub-case (b) or (d)]. The Z1, Z2 and Z5 radicals may have any substitution within the maximum range stated [("and" linkage in 10 cases (A) to (D)]. In case (B), the novel pyrido[2,3-b]pyrazine derivatives may be substituted by "substituted heteroaryl" in at least one of their Z3, Z4 radicals, the novelty arising either by virtue of sub-case (a) or by virtue of sub-case (c). If only one Z3, Z4 radical is novel "substituted heteroaryl", the other Z3, Z4 radical in each case may have any 15 substitution within the maximum range stated [("and" linkage in subcase (d)]. Optionally, both Z3, Z4 radicals may also have further substitution [sub-case (b) or (d)]. The Z1, Z2 and Z5 radicals may have any substitution within the maximum range stated [("and" linkage in cases (A) to (D)]. In case (C), the novel pyrido[2,3-b]pyrazine derivatives may be substituted in a 20 novel manner by "substituted alkyl" or "(C 9

-C

30 )alky" in at least one of their Z3, Z4 radicals. If only one Z3, Z4 radical is novel "substituted alkyl" or "(C 9

-C

30 )alkyl", the other Z3, Z4 radical in each case may have any desired substitution within the maximum range stated [("and" linkage in sub-case "(C 9

-C

30 )alkyl"]. Z1, Z2 and Z5 radicals have any substitution within the maximum range stated [("and" linkage in 25 cases (A) to (D)]. In case (D), the novel pyrido[2,3-b]pyrazine derivatives may be substituted by "-NZ1 OZ1 1, -OZ1 2, -SZ1 3" in at least one of their Z3, Z4 radicals, the novelty arising either by virtue of sub-case (a) or by virtue of sub-case (b). If only one Z3, Z4 radical is novel "-NZ1 OZ1 1, -OZ1 2, -SZ1 3", the other Z3, Z4 radical in each case may have any 30 desired substitution within the maximum range stated [("and" linkage in sub-case (b)]. Z1, Z2 and Z5 radicals have any desired substitution within the maximum range stated [("and" linkage in cases (A) to (D)].

W02007/054556 PCT/EP2006/068322 -170 In case (E), the novel pyrido[2,3-b]pyrazine derivatives may be substituted by "-NZ24Z25, -NZ26Z27" in at least one of their Z1, Z2 radicals, the novelty arising either by virtue of sub-case (a)(1), sub-case (b)(1)(l), sub-case (b)(1)(1I) or sub-case (b)(2). If only one Z1, Z2 radical is novel "-NZ24Z25, -NZ26Z27", the other Z1, Z2 radical in 5 each case may have any substitution within the maximum range stated [sub-cases (c), (d)] [("and" linkage in sub-case (b)(2)]. Z3, Z4 and Z5 radicals have any substitution within the maximum range stated [("and" linkage in sub-case (d)]. In a preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general 10 formula (1) are provided, where, in (A), the Z1 radical is independently "NZ1 4Z1 5"; where Z1 4 is hydrogen or "aryl" and Z15 is "-C(O)NH-alky"; where "-C(O)NH-alkyl" may additionally, optionally, be substituted by "-OH"; the Z2 radical is independently hydrogen; 15 the Z3 radical is independently "substituted aryl", where "substituted aryl" is substituted by at least one substituent selected identically or differently from the group consisting of: (a) "alkyl, -OC(O)-alkyl, -0-alkyl, -NHC(O)-alkyl"; with the proviso that the above substituents of substituent group (a) are each 20 independently substituted further by at least one substituent selected identically or differently from the group consisting of: (i) "aryl, heterocyclyl, -O-alkyl-0-alkyl, -0-arylalkyl"; or the Z3 radical is independently "substituted aryl", where "substituted aryl" is substituted by at least one substituent selected identically or differently from the 25 group consisting of: (c) "-OC(O)-O-akyl,-OC(O)-O-aryl, -OC(O)-N(alkyl) 2 , -OC(O)-NH-alkyl, OC(O)-(C 9

-C

30 )alkyl, -NHC(O)-O-alkyl, -NHC(O)-NH-alkyl, -NHC(O) N(alkyl) 2 , -Si(alkyl) 3 "; where, optionally, the above substituents of substituent group (c) may in turn 30 each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 - 171 (i) "-O-alkyl, -O-arylalkyl"; where, optionally, the Z3 radical may also independently be substituted by at least one substituent selected identically or differently from the group consisting of: (d) "halogen, F, Cl, Br, I, -0-alkyl"; 5 the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen In a preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (A), 10 the Z1 radical is independently selected from the group consisting of "-NHC(O)NH ethyl, -NHC(O)NH-butyl-OH"; the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "4-phenyl methyl carbonate, 3-phenyl 2-methoxyethyl carbonate, 4-phenyl 2-methoxyethyl 15 carbonate, 4-phenyl phenyl carbonate, 4-phenyl N-diethylcarbamate, 4-phenyl 3 phenylacrylate, 4-phenyl nonadecanoate, 4-phenyl isobutyl carbonate, 4-phenyl but-2-ynyl carbonate, 4-phenyl N-dimethylcarbamate, 4-phenyl N-ethylcarbamate, tert-butyl N-(4-phenyl)carbamate, 2-methoxyethyl N-(4-phenyl)carbamate, 4-(3 ethylurea)phenyl, 4-(3,3-methylurea)phenyl, 4-morpholin-4-ylmethylphenyl, 4-[2-(2 20 methoxyethoxy)ethoxy]phenyl, N-(4-phenyl)-2-(2-methoxyethoxy)acetamide, 4-(2 methoxy)phenyl 2-methoxyethyl carbonate, 4-phenyl 2-benzyloxyethyl carbonate, 4-(2-methoxy)phenyl 2-benzyloxyethyl carbonate, N-(4-phenyl)-2 benzyloxyacetamide, 3-trimethylsilanylphenyl, 4-(2-methoxy)phenyl N diethylcarbamate, 4-(2-chloro-6-methoxy)phenyl N-diethylcarbamate, 4-(2 25 methoxy)phenyl 2-[2-(2-methoxyethoxy)ethoxy]ethy carbonate"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the 30 general formula (1) are provided, where, in (B), W02007/054556 PCT/EP2006/068322 -172 the Z1 radical is independently "NZ1 4Z1 5"; where Z14 is hydrogen and Z15 is C(O)NH-alkyl"; the Z2 radical is independently hydrogen; the Z3 radical is independently "substituted heteroaryl", where "substituted 5 heteroaryl" is substituted by at least one substituent selected identically or differently from the group consisting of: (a) "-NHC(O)-NH-alkyl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 10 In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (B), the Z1 radical is independently selected from the group consisting of "-NHC(O)NH ethyl"; 15 the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "6-(3 ethylurea)pyridin-3-yl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 20 In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (C), the Z1 radical is independently "NZ14Z1 5"; where Z14 is hydrogen and Z15 is C(O)NH-alkyl"; 25 the Z2 radical is independently hydrogen; the Z3 radical is independently "substituted alkyl", where "substituted alkyl" is substituted by at least one substituent selected identically or differently from the group consisting of: (a) "aryl, heteroaryl, cycloalkyl, -N(alkyl) 2 , -O-alkyl"; W02007/054556 PCT/EP2006/068322 - 173 where, optionally, the above substituents of substituent group (a) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "halogen, F, Cl, Br, I"; 5 the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (C), 10 the Z1 radical is independently selected from the group consisting of "-NHC(O)NH ethyl"; the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "phenylethynyl, thiophen-3-ylethynyl, cyclopropylethynyl, N-dimethylaminoprop-1 15 ynyl, 2-cyclohexylvinyl, 3-methoxypropenyl, benzyl, 2-(4-fluorophenyl)ethyl, 2-(4 fluorophenyl)vinyl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 20 In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (D), the Z1 radical is independently "NZ14Z1 5"; where Z14 is hydrogen and Z15 is C(O)NH-alkyl"; the Z2 radical is independently hydrogen; 25 the Z3 radical is independently selected from the group consisting of: (1) "-NZ1OZ11"; where.the Z10, Z11 radicals are each independently selected from the group consisting of: (a) "hydrogen, aryl"; W02007/054556 PCT/EP2006/068322 -174 with the proviso that the above substituents of substituent group (a), when they are not hydrogen, are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: 5 (i) "cycloalkyl, heteroaryl, heterocyclylalkyl, -S(O) 2 -alkyl, -NH-S(O) 2 -alkyl, -C(O)NH-alkyl, -NH-C(O)-alkyl, -C(0)0-alkyl"; (b) "-C(O)-aryl"; where, optionally, the above substituents of substituent group (a) and/or substituent group (b) may each independently be substituted by at least one 10 substituent selected identically or differently from the group consisting of: (i) "alkyl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 15 In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (D), the Z1 radical is independently selected from the group consisting of "-NHC(O)NH ethyl"; the Z2 radical is independently hydrogen; 20 the Z3 radical is independently selected from the group consisting of "4 methylbenzamide, 4-cyclohexylphenylamino, 4-methanesulphonylphenylamino, 3 (N-methanesulphonamide)-4-methylphenylamino, 3-N-methylbenzamideamino, 4 piperidin-1 -ylmethylphenylamino, 4-thiophen-3-ylphenylamino, 4-N acetamidophenylamino, 3-(ethyl benzoate)amino"; 25 the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (E), 30 the Z1 radical is independently selected from the group consisting of: W02007/054556 PCT/EP2006/068322 -175 (a) "NZ24Z25"; where Z24 is hydrogen and Z25 is "-C(O)-C(O)-O-alkyl" or C(O)-C(O)-NH-alkyl" or "-C(O)-NH-O-alkyl"; where, optionally, the above substituents of substituent group (a) may each independently be substituted by at least one substituent selected identically or 5 differently from the group consisting of: (i) "-OSi(alkyl) 3 , -OC(O)-NH-alkyl, -OC(O)-O-alkyl, -P(O)(0-alkyl) 2 , P(O)(OH) 2 , -0-alkyl"; where, optionally, the above substituents of substituent group (i) may also each independently be substituted further by at least one substituent 10 selected identically or differently from the group consisting of: (ii) "heterocyclyl, OH, -N(alkyl) 2 , -OC(O)-alkyl"; where, optionally, the above substituents of substituent group (ii) may also each independently be substituted further by at least one substituent selected identically or differently from the group consisting 15 of: (iii) "alkyl"; (b) "NZ26Z27"; where Z26 is hydrogen and Z27 is "-C(O)-NH-alkyl"; with the proviso that the above substituents of substituent group (b) are each independently substituted further by at least one substituent selected identically 20 or differently from the group consisting of: (i) "-OSi(alkyl) 3 , -OC(O)-NH-alkyl, -OC(O)-O-alkyl, -P(O)(0-alkyl) 2 , P(O)(OH) 2 , -0-alkyl"; where, optionally, the above substituents of substituent group (i) may also each independently be substituted further by at least one substituent 25 selected identically or differently from the group consisting of: (ii) "heterocyclyl, OH, -N(alkyl) 2 , -OC(O)-alkyl"; where, optionally, the above substituents of substituent group (ii) may also each independently be substituted further by at least one substituent selected identically or differently from the group consisting 30 of: (iii) "alkyl"; W02007/054556 PCT/EP2006/068322 -176 the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of: (a) "aryl"; where, optionally, the above substituents of substituent group (a) may each 5 independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "-O-alkyl, OH"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 10 In a further preferred embodiment, novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) are provided, where, in (E), the Z1 radical is independently selected from the group consisting of "3-methoxy-1 ylurea, 3-(prop-1-yn-3-yl)-1-ylurea, 3-[4-(tert-butyldimethylsilanyloxy)butyl]-1-ylurea, 15 4-(N-ethyl carbamate)butyl-1-ylurea, 4-(methyl carbonate)butyl-1-ylurea, 4-(2,3 dihydroxypropyl carbonate)butyl-1-ylurea, 4-(2,2-dimethyl-[ 1, 3]dioxolan-4-ylmethyl carbonate)butyl-1-ylurea, 4-(diethyl phosphate)butyl-1-ylurea, 4-(butyl phosphate) 1-ylurea, N-oxalic monoamide ethyl ester, N-ethyl-N'-oxalamide, 2-(diethyl phosphate)ethyl-1-ylurea, 2-(ethyl phosphate)-1 -ylurea, 3-(2-diethylamino 20 ethoxy)propyl-1-ylurea, 4-[(2,2-dimethylpropionyloxymethoxy)phosphinoyloxy methyl 2,2-dimethylpropanoate]butyl-1-ylurea, 4-[1-(1-acetoxyethoxy)ethoxy phosphinoyloxy acetate]butyl-1-ylurea"; the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "phenyl, 4 25 hydroxy-3-methoxyphenyl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. A further aspect of the present application relates to novel compounds from the 30 group of the pyrido[2,3-b]pyrazines of the general formula (II), W02007/054556 PCT/EP2006/068322 -177 R2 N R4 R1 N R3 in which the substituents R1-R4 are each defined as follows: 5 R1 and R2 may each independently be hydrogen or NR5R6, with the prerequisite that when R1 = NR5R6, R2 = H, and when R2 = NR5R6, R1 = H, where R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, 10 cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be mono- or polysubstituted, identically or differently, by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H,

OP(O)(OH)

2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 ,CHO, C(O)OH, C(O)OR12, C(O)NH 2 , 15 C(O)NHR12, C(O)NR12R13, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, p may assume the value of 0, 1, 2, 3, 4 or 5 and the R1 2 and R1 3 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R1 2 and R1 3 together may form a heterocyclyl ring 20 and R6: may be -C(Y)NR7R8 where Y may independently be 0 or S and R7 and R8 may each independently be 25 hydrogen, unsubstituted or substituted alkyl, where the alkyl radical may be mono- or polysubstituted, identically or differently, by F, C, Br, I, CF 3 , CN, NH 2 , NH-alkyl, 30 NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylcycloalkyl, NH alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , NHC(O)-alkyl, W02007/054556 PCT/EP2006/068322 .- 178 NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O)-alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl,

NHSO

2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 alkylheteroaryl, NO 2 , SH, S-alkyl, S-cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, 5 OH, OCF 3 , O(-alkylO)p-alkyl, 0-cycloalkyl, 0-heterocyclyl, 0-aryl, 0-heteroaryl, 0 alkylcycloalkyl, 0-alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O) alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OS0 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 heterocyclyl, OS0 2 -aryl, OSO 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 -alkylheteroaryl, 10 OP(O)(OH) 2 , C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, CO2 cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH 15 alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO-alkyl, SO-aryl, S0 2 -alkyl, S0 2 -aryl, SO 2

NH

2 , SO 2 NH-alkyl, SO 2 NH-aryl, SO 2

NH

heteroaryl, SO 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3,4or5, 20 unsubstituted or substituted cycloalkyl, where the cycloalkyl radical may be mono or polysubstituted, identically or differently, by F, Cl, Br, I, NH 2 , NH-alkyl, NH cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylaryl, NH alkylheteroaryl, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, 25 NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O)-alkylheteroaryl,

NHSO

2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, OH, O(-alkylO)p-alkyl, 0 cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, 0-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, 30 OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OS0 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 alkylheteroaryl, OP(O)(OH) 2 , CO 2 H, C0 2 -alkyl, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH 35 heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH- W02007/054556 PCT/EP2006/068322 -179 alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , alkyl, or aryl, where p may assume the value of 0, 1, 2, 3, 4 or 5, 5 unsubstituted or substituted heterocyclyl, where the heterocyclyl radical may be mono- or polysubstituted, identically or differently, by OH, O-alkyl, O-aryl, NH 2 , NH alkyl, NH-aryl, alkyl, alkylaryl or aryl, unsubstituted or substituted aryl, where the aryl radical may be mono- or 10 polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) 15 alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl,

NHSO

2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, 0-cycloalkyl, 0-heterocyclyl, 0-aryl, 0-heteroaryl, 0-alkylcycloalkyl, 0 alkylheterocyclyl, O-alkylaryl, 0-alkylheteroaryl, O-alkylOH, O-(CH 2 )n-O, OC(O) 20 alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O) heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OS0 2 -alkyl, OS0 2 cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, C0 2 H, C02 alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C02 25 alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO-alkyl, SO-aryl, S0 2 -alkyl, S0 2 -aryl, SO 2

NH

2 , 30 SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO3H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and n the value of 1, 2 or 3, unsubstituted or substituted heteroaryl, where the heteroaryl radical may be mono 35 or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, W02007/054556 PCT/EP20061068322 - 180 NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) 5 alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl,

NHSO

2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, 0-cycloalkyl, 0 heterocyclyl, O-aryl, 0-heteroaryl, 0-alkylcycloalkyl, 0-alkylheterocyclyl, 0 alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O) 10 heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl,

OSO

3 H, OSO 2 -alkyl, OSO 2 -cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OSO 2 heteroaryl, OSO 2 -alkylaryl, OS0 2 -alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O) aryl, C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, 15 C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO 2

NH

2 ,

SO

2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, 20 S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5, -C(O)-R39 where R39 may be alkyl, aryl or heteroaryl, and the alkyl, aryl and heteroaryl substituents may themselves in turn be substituted, 25 or R7 and R8 together may form a heterocyclyl ring, R3 and R4 may each independently be: 30 hydrogen, where R3 and R4 are not simultaneously hydrogen, substituted alkyl, where the alkyl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H, OP(O)(OH) 2 , 35 OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)OH, C(O)OR14, C(O)NH 2 , C(O)NHR14, W02007/054556 PCT/EP2006/068322 - 181 C(O)NR14R15, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R14 and R15 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl 5 or alkylheteroaryl, or R14 and R15 together may form a heterocyclyl ring, substituted aryl, where the aryl radical is mono- or polysubstituted, identically or differently, by substituents selected from the group of NH-alkyl, NH-cycloalkyl, NH heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylcycloalkyl, NH-alkylheterocyclyl, NH 10 alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , N(aryl) 2 , NHC(O)-alkyl, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl,

NHSO

2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, S-alkyl, S-aryl, S heteroaryl, 0-alkyl, 0-cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, 0 15 alkylcycloalkyl, 0-alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O) alkylaryl, OC(O)-alkylheteroaryl, OS0 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 -alkylheteroaryl, C(O)-alkyl, C(0)-aryl, C(O)-heteroaryl, C0 2 -alkyl, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, 20 C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C02 alkylheteroaryl, C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO-alkyl, SO-aryl, S0 2 -alkyl, S0 2 -aryl, S0 2

NH

25 alkyl, SO 2 NH-aryl, S0 2 NH-heteroaryl, S0 2 NH-alkylaryl, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents are themselves in turn substituted by O(-alkylO)p alkyl, OP(O)(Oalkyl) 2 , OP(O)(Oaryl)2, C(O)OR16, C(O)NH 2 , C(O)NHR16, 30 C(O)NR16R17, S0 2 alkyl, SO2aryl, P(O)(OH) 2 , P(0)(Oalkyl) 2 , P(0)(Oaryl)2, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 1, 2, 3, 4 or 5, and the R16 and R17 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R16 and R17 together may form a heterocyclyl ring, W02007/054556 PCT/EP2006/068322 -182 with the prerequisite that when R3 or R4 is alkyiheterocyclyl-substituted aryl, R4 or R3 is correspondingly aryl, and where the aryl radical is mono- or polysubstituted, identically or differently, by 5 substituents selected from the group of NR20-alkyl, NH-R38, NHC(O)-R38, NR19C(O)-alkyl, NR19C(O)-cycloalkyl, NR19C(O)-heterocyclyl, NR19C(O)-aryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O)-alkylheterocyclyl, NR19C(O)-alkylaryl, NR19C(O)-alkylheteroaryl, NR18C(O)O-RI9, NR18C(O)NR18R18, O-R38, OC(O)-R38, OC(O)-alkylcycloalkyl, OC(O) 10 alkylheterocyclyl, OC(O)O-R19, OC(O)NR18R18, OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)O-R38, C(O)NH-R38, C(O)NR20-alkyl, C(O)NR19-alkylR21, C(O)NR180-R18, C(O)NR18NR18R18 and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents may themselves in turn be substituted by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, 15 N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , 0(-alkylO)p-alkyl, O-aryl, OSO 3 H,

OP(O)(OH)

2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , CHO, C(O)OH, C(O)OR22, C(O)NH 2 , C(O)NHR22, C(O)NR22R23, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R22 and R23 radicals may each 20 independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R22 and R23 together may form a heterocyclyl ring, substituted heteroaryl, where the heteroaryl radical is mono- or polysubstituted, 25 identically or differently, by substituents selected from the group of NH-alkyl, NH cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylcycloalkyl, NH alkylheterocycly, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , N(aryl) 2 , NHC(O)-alkyl, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O)-alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, 30 NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 alkylheteroaryl, S-alkyl, S-aryl, S-heteroaryl, 0-alkyl, O-cycloalkyl, O-aryl, 0 heteroaryl, O-alkylcycloalkyl, O-alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 2 -alkyl, OS0 2 -cycloalkyl, OSO 2 35 heterocyclyl, OS0 2 -aryl, OSO 2 -heteroaryl, OSO 2 -alkylaryl, OS0 2 -alkylheteroaryl, W02007/054556 PCT/EP2006/068322 -183 C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, C0 2 -alkyl, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH 5 alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl)2, C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO 2 NH-alkyl, S0 2 NH-aryl,

SO

2 NH-heteroaryl, S0 2 NH-alkylaryl, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl 10 substituents are themselves in turn substituted by O(-alkylO),-alkyl, OP(O)(Oalkyl) 2 , OP(0)(Oaryl) 2 , C(O)OR16, C(O)NH 2 , C(O)NHR16, C(O)NR16R17, SO 2 alkyl,

SO

2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 1, 2, 3, 4 or 5 and the R16 and R1 7 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, 15 heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R16 and R17 together may form a heterocyclyl ring, and where the heteroaryl radical is mono- or polysubstituted, identically or differently, by substituents selected from the group of NR20-alkyl, NH-R38, 20 NHC(O)-R38, NR19C(O)-alkyl, NR19C(O)-cycloalkyl, NR19C(O)-heterocyclyl, NR19C(O)-aryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O) alkylheterocyclyl, NR19C(O)-alkylaryl, NR19C(O)-alkylheteroaryl, NR18C(0)0 R19, NR18C(O)NR18R18, NHSO 2 -alkylheterocyclyl, O-R38, 0-heterocyclyl, OC(O)-R38, OC(O)-alkylcycloalkyl, OC(O)-alkylheterocyclyl, OC(O)O-R19, 25 OC(O)NR18R18, OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)O-R38, C(O)NH-R38, C(O)NR20-alkyl, C(O)NR19-alkylR21, C(O)NR180-R18, C(O)NR18NR18R18, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents may themselves in turn be substituted by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , 30 0(-alkylO)p-alkyl, O-aryl, OSO 3 H, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl)2, CHO, C(O)OH, C(O)OR22, C(O)NH 2 , C(O)NHR22, C(O)NR22R23, SO 3 H,

SO

2 alkyl, SO 2 aryl, P(0)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl)2, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R22 and R23 radicals may each independently be alkyl, W02007/054556 PCT/EP2006/068322 - 184 cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R22 and R23 together may form a heterocyclyl ring, NR24R25 where R24 may be-C(O)-R26, -S0 2 R26, -C(O)OR26 or -C(0) 5 NR27R28 and where R25 may be hydrogen, alkyl, cycloalkyl, aryl or heteroaryl and where R26 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, and R27 and R28 may each independently be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, or R27 and R28 together 10 may form a heterocyclyl ring and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be substituted, and R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, 15 alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, 20 and R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, 25 and R38 may be alkyl, where the alkyl radical may be saturated or unsaturated, straight-chain or branched, having from 9 to 30 carbon atoms, i.e. C 9

-

30 -alkanyls,

C

9

-

30 -alkenyls and C 9

-

30 -alkynyls. Alkenyls have at least one C-C double bond and alkynyls have at least one C-C triple bond, where the alkenyls may be present either in (E)- or in (Z)-conformation. It is preferred that the alkyl radical is selected 30 from the group which comprises nonyl, decyl, dodecyl, hexadecyl, octadecyl, eicosyl, henicosyl, docosyl, tetracosyl, nonacosyl, octadecenyl, docosenyl, tetracosenyl and octadecynyl.

W02007/054556 PCTIEP2006/068322 -185 In a further aspect, the present application describes novel compounds from the group of the pyrido[2,3-b]pyrazines of the general formula (II), R2 N R4 R1 N R3 (I) 5 in which the substituents R1-R4 are each defined as follows: R1 and R2 may each independently be hydrogen or NR5R6, with the prerequisite that when R1 = NR5R6, R2 = H, and when R2 = NR5R6, R1 = H, where R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, 10 cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be mono- or polysubstituted, identically or differently, by F, Cl, Br, 1, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H,

OP(O)(OH)

2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , CHO, C(O)OH, C(O)NH 2 , C(O)OR12, 15 C(O)NHR12, C(O)NR12R13, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, p may assume the value of 0, 1, 2, 3, 4 or 5 and the R1 2 and R1 3 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R12 and R13 together may form a heterocyclyl ring 20 and R6: may be -C(O)NR9-Y-R10 where Y may independently be 0 or NR1 1 25 and R9 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves be substituted, 30 and R10 and RI 1 may each independently be W02007/054556 PCT/EP2006/068322 -186 hydrogen, unsubstituted or substituted alkyl, 5 unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, where the heterocyclyl radical may be mono- or polysubstituted, identically or differently, by OH, 0-alkyl, O-aryl, NH 2 , NH alkyl, NH-aryl, alkyl, alkylaryl or aryl, 10 unsubstituted or substituted aryl, where the aryl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, 1, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH 15 alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl,

NHSO

2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, 20 0-cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, O-alkylcycloalkyl, 0 alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, O-alkylOH, 0-(CH 2 )n-O, OC(O) alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O) heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OS0 2 -alkyl, OS0 2 cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 25 alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, CO 2 H, C02 alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C02 alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, 30 C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO-alkyl, SO-aryl, S0 2 -alkyl, S0 2 -aryl, SO 2

NH

2 ,

SO

2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO3H, S0 2 0-alkyl, S020-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and n the value of 1, 2 or 3, 35 W02007/054556 PCT/EP2006/068322 - 187 unsubstituted or substituted heteroaryl, where the heteroaryl radical may be mono or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH 5 alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl,

NHSO

2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, 0-cycloalkyl, 0 10 heterocyclyl, O-aryl, 0-heteroaryl, 0-alkylcycloalkyl, 0-alkylheterocyclyl, 0 alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O) heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl,

OSO

3 H, OS0 2 -alkyl, OS0 2 -cycloalkyl, OSO 2 -heterocyclyl, OS0 2 -aryl, OSO 2 heteroaryl, OS0 2 -alkylaryl, OS0 2 -alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O) 15 aryl, C(O)-heteroaryl, C0 2 H, C0 2 -alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, 20 C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO 2

NH

2 ,

SO

2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5, 25 or R10 and R1 1 together may form a heterocyclyl ring, R3 and R4 may each independently be: hydrogen 30 hydroxyl halogen such as fluorine, chlorine, bromine, iodine W02007/054556 PCT/EP2006/068322 -188 unsubstituted or substituted alkyl, where the alkyl radical may be mono- or polysubstituted, identically or differently, by F, CI, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H,

OP(O)(OH)

2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)OH, C(O)OR14, C(O)NH 2 , 5 C(O)NHR14, C(O)NR14R15, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R14 and R15 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R14 and R15 together may form a heterocyclyl ring, 10 unsubstituted or substituted aryl, where the aryl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , 15 N(aryl) 2 , NR20-alkyl, NHC(O)-alkyl, NHC(O)-R38, NR19(O)-alkyl, NHC(O) cycloalkyl, NR19C(O)-cycloalkyl, NHC(O)-heterocyclyl, NR19C(O)-heterocyclyl, NHC(O)-aryl, NR19C(O)-aryl, NHC(O)-heteroaryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O)-alkylheterocycly, NHC(O)-alkylaryl, NR19C(O)-alkylaryl, NHC(O)-alkylheteroaryl, NR19C(O)-alkylheteroaryl, 20 NR18C(O)O-R19, NR18C(O)NR18R18, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylheterocycly, NHSO 2 alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S-aryl, S-heteroaryl, OH, OCF 3 , 0-alkyl, O-R38, 0-cycloalkyl, 0-heterocyclyl, 0-aryl, 0-heteroaryl, 0 alkylcycloalkyl, 0-alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, O-(CH2)n-O, 25 OC(O)-alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylcycloalkyl, OC(O)-alkylheterocyclyl OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OC(O)O-R19, OC(O)NR18R18, OSO 3 H, OS0 2 -alkyl, OS0 2 cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 alkylheteroaryl, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)-alkyl, C(O)-aryl, 30 C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C02-aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, 35 C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , C(O)NR20- W02007/054556 PCT/EP2006/068322 -189 alkyl, C(O)NR1 9-alkyIR21, -C(O)NR1 80-Ri 8, -C(O)NRI 8NR1 8R1 8, SO-alkyl, SO aryl, S0 2 -alkyl, S0 2 -aryl, S0 2

NH

2 , SO 2 NH-alkyl, S0 2 NH-aryl, S0 2 NH-heteroaryl, S0 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, cycloalkyl, heterocyclyl, 5 aryl or heteroaryl, n may assume the value of 1, 2 or 3, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents may themselves in turn be substituted, unsubstituted or substituted heteroaryl, where the heteroaryl radical may be mono 10 or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , N(aryl) 2 , NR20-alkyl, NHC(O)-alkyl, NHC(O)-R38, NR19C(O)-alkyl, NHC(O) cycloalkyl, NR19C(O)-cycloalkyl, NHC(O)-heterocyclyl, NR19C(O)-heterocyclyl, 15 NHC(O)-aryl, NR19C(O)-aryl, NHC(O)-heteroaryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O)-alkyiheterocyclyl, NHC(O)-alkylaryl, NR19C(O)-alkylaryl, NHC(O)-alkylheteroaryl, NR19C(O)-alkylheteroaryl, NR18C(O)O-R19, NR18C(O)NR18R18, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylheterocycly, NHSO 2 20 alkylaryl, NHS0 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S-aryl, S-heteroaryl, OH, OCF 3 , O-alkyl, O-R38, 0-cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, 0 alkylcycloalkyl, 0-alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(0)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylcycloalkyl, OC(O)-alkylheterocyclyl OC(O)-alkylaryl, OC(O) 25 alkylheteroaryl, OC(O)O-R19, OC(O)NR18R18, OS0 3 H, OS0 2 -alkyl, OS02 cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 alkylheteroaryl, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, 30 C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(0)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(0)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , C(0)NR20 alkyl, C(O)NR19-alkylR21, -C(O)NR180-R18, -C(O)NR18NR18R18, SO 2

NH

2 , 35 SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO3H, S0 2 0-alkyl, W02007/054556 PCT/EP2006/068322 - 190 S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents may themselves in turn be substituted, 5 OR29 where R29 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be substituted, 10 SR30 where R30 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be substituted, 15 NR31 R32 where R31 and R32 may each independently be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, -C(O)-R33, -S0 2 R33, -C(O)OR33 and -C(O)-NR34R35, where R33 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, 20 alkylheterocyclyl, alkylaryl, alkylheteroaryl, and R34 and R35 may each independently be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, or R34 and R35 together may form a heterocyclyl ring, or R31 and R32 together may form a heterocyclyl ring, 25 and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be substituted, and R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, 30 alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, W02007/054556 PCT/EP2006/068322 -191 and R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, 5 and R38 may be alkyl, where the alkyl radical may be saturated or unsaturated, straight-chain or branched, having from 9 to 30 carbon atoms, i.e. C 9

-

3 0 -alkanyls,

C

9

-

3 -alkenyls and Cg- 30 -alkynyls. Alkenyls have at least one C-C double bond and alkynyls have at least one C-C triple bond, where the alkenyls may be present 10 either in (E)- or in (Z)-conformation. It is preferred that the alkyl radical is selected from the group which comprises nonyl, decyl, dodecyl, hexadecyl, octadecyl, eicosyl, henicosyl, docosyl, tetracosyl, nonacosyl, octadecenyl, docosenyl, tetracosenyl and octadecynyl. 15 Particular preference is given to pyrido[2,3-b]pyrazine derivatives of the general formula (11), where R2 = H. Particular preference is further given to pyrido[2,3-b]pyrazine derivatives of the general formula (II), where R2 and R4 = H. 20 Particular preference is given to the following pyrido[2,3-b]pyrazine derivatives of the general formulae (1) and (II) which may be present in the form of their free base or else as pharmaceutically acceptable salts of physiologicall tolerated acids: 25 Compound 1 1 -ethyl-3-(3-phenylethynylpyrido[2,3-b]pyrazin-6-yl)urea NN N N H H Compound 2 1 -ethyl-3-(3-thiophen-3-ylethynylpyrido[2, 3-blpyrazin-6-yl)urea W02007/054556 PCT/EP2006/068322 -192 N ~N N QN H HN s Compound 3 1-(3-cyclopropylethynylpyrido[2,3-b]pyrazin-6-yl)-3-ethylurea H H Compound 4 1-[3-(3-dimethylaminoprop-1 -ynyl)pyrido[2,3-b]pyrazin-6-yl]-3 5 ethylurea 'N NQN N H H N Compound 5 1-[3-((E)-2-cyclohexylvinyl)pyrido(2,3-b]pyrazin-6-yl]-3-ethylurea N NNN N N H H Compound 6 1 -ethyl-3-[3-((E)-3-methoxypropenyl)pyrido[2,3-b]pyrazin-6-yl] urea N 'N N O 10 H H Compound 7 H H Compound 8 W02007/054556 PCT/EP2006/068322 - 193 H H Compound 9 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny methyl carbonate aN H H Compound 10 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny 2-methoxyethyl 5 carbonate N N - . H HO O O Compound 11 463O hnype Compound 11 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny phenyl carbonate N i N N H H O Ni0 Compound 12 4-[6-(3-ethylurea)pyrido[2, 3-b]pyrazin-3-yI]phenyl diethylcarbamate N HH-- I N N .,NJ N, 10 Compound 13 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl (E)-3 phenylacrylate 'N<N N NN N Compound 14 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl nonadecanoate W02007/054556 PCT/EP2006/068322 -194 N. N N N N H H Compound 15 1-(3-benzylpyrido[2,3-b]pyrazin-6-yI)-3-ethylurea 0N N O "- NN N'- N H H Compound 16 3-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyli 2-methoxyethyl 5 carbonate N. -- N INN N H H I Compound 17 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl isobutyl carbonate N H H0 0 Compound 18 but-2-ynyl 4-[6-(3-ethylurea)pyrido[2, 3-b]pyrazin-3-yI]pheny 10 carbonate ~ N ~ N , I N H H0 0 Compound 19 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yllphenyI dimethylcarbamate K~N H H 0 N W02007/054556 PCT/EP2006/068322 -195 Compound 20 4-[6-(3-ethyl-1-phenylurea)pyrido[2,3-b]pyrazin-3-yl]pheny ethylcarbamate N H N H Compound 21 tert-butyl {4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl} 5 carbamate N N N N H H N O H Compound 22 2-methoxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl} carbamate '--N N N N H H N O Os H 10 Compound 23 1 -ethyl-3-{3-[4-(3-ethylurea)phenyl]pyrido[2,3-b]pyrazin-6-yl}urea N H H Compound 24 1 -{3-[4-(3,3-dimethylurea)phenyl]pyrido[2,3-b]pyrazin-6-yl}-3 ethylurea H H N N H 15 Compound 25 1 -ethyl-3-{3-[6-(3-ethylurea)pyridin-3-yl]pyrido[2,3-b]pyrazin-6 yl}urea W02007/054556 PCT/EP2006/068322 - 196 N IN N HH N N N H H Compound 26 1 -ethyl-3-{3-[2-(4-fluorophenyl)ethyl]pyrido[2,3-b]pyrazin-6-yl}urea H H F Compound 27 1 -ethyl-3-{3-[(E)-2-(4-fluorophenyl)vinyl]pyrido[2,3-b]pyrazin-6-y} 5 urea H H F Compound 28 1 -ethyl-3-[3-(4-morpholin-4-ylmethylphenyl)pyrido[2,3-b]pyrazin-6 yl]urea N N H H (N 10 Compound 29 1 -ethyl-3-(3-{4-[2-(2-methoxyethoxy)ethoxy]phenyl}pyrido[2,3 b]pyrazin-6-yl)urea '_NN N N H H Compound 30 N-{4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl}-2-(2 methoxyethoxy)acetamide W02007/054556 PCT/EP2006/068322 - 197 '-NN N N H H H Compound 31 N-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]-4-methylbenzamide "--N NN N 11N H H H Compound 32 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yi]-2-methoxyphenyl 2 5 methoxyethyl carbonate N " N N N N a H HO O O Compound 33 2-benzyloxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny carbonate o- Q H H 0 0--,-,",1 10 Compound 34 2-benzyloxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-y]-2 methoxyphenyl carbonate H I Compound 35 2-benzyloxy-N-{4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl} 15 acetamide NN O '--N NAN H H H 0"0

H

W02007/054556 PCT/EP2006/068322 -198 Compound 36 1-[4-(tert-butyldimethylsilanyloxy)butylJ-3-(3-phenylpyrido[2,3-b] pyrazin-6-yl)urea H HI Compound 37 1 -[4-(tert-butyldimethylsilanyloxy)butyl]-3-[3-(4-hydroxy-3 5 methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea N N N N)" OH Compound 38 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyI ethylcarbamate HH Compound 39 methyl 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]buty carbonate H H 0 10 Compound 40 2,2-dimethyl[1,3]dioxolan-4-ylmethyl 4-[3-(3-phenylpyrido[2,3 b]pyrazin-6-yl)urea]butyl carbonate N 0 0 15 Compound 41 2,3-dihydroxypropyl 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea] butyl carbonate W02007/054556 PCT/EP2006/068322 - 199 N H HO O O Compound 42 diethyl {4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl} phosphate SN~ o N- N N o H H 5 Compound 43 {4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl}phosphoric acid Ho N N HO H H Compound 44 diethyl (4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3-blpyrazin-6 yl]urealbutyl)phosphate o' N N HH OH 10 Compound 45 (4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3-b]pyrazin-6 yl]urea}butyl)phosphoric acid HON N N/ ON HO H H OH Compound 46 1 -ethyl-3-[3-(3-trimethylsilanylphenyl)pyrido[2,3-b]pyrazin-6-yl]urea Ns H H 15 Compound 47 1 -[3-(4-cyclohexylphenylamino)pyrido[2, 3-b]pyrazin-6-yI]-3-ethylurea W02007/054556 PCT/EP2006/068322 - 200 N N N ,' 'N ~QN N Na H H H Compound 48 1 -ethyl-3-[3-(4-methanesulphonylphenylamino)pyrido[2,3-b]-pyrazin 6-yl]urea N NN N N N H H H 5 Compound 49 N-{5-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]-2-methyl phenyl)methanesulphonamide N "-N' N Nt"N' N NS H H H H Compound 50 3-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]-N-methyl benzamide N H N N N N H H H 10 0 Compound 51 1 -ethyl-3-[3-(4-piperidin-1 -ylmethylphenylamino)pyrido[2,3-b] pyrazin-6-yl]urea NN N H H H Compound 52 1 -ethyl-3-[3-(4-thiophen-3-ylphenylamino)pyrido[2,3-b]pyrazin-6 15 yl]urea S ,AN N N N N H H H Compound 53 N-{4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]phenyl} acetamide W02007/054556 PCT/EP2006/068322 - 201 H N N N N H H H Compound 54 ethyl 3-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]benzoate '-N N N >N N H H H 0 Compound 55 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl 2-methoxyethyl 5 carbonate hydrochloride N N N x HCI O Compound 56 2-methoxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny carbonate p-toluenesulphonate N N N H Ho o O x HO 0 10 Compound 57 4-{6-[3-(4-hydroxybutyl)urea]pyrido[2,3-b]pyrazin-3-yl}phenyl 2 methoxyethyl carbonate H N H H 0 o eN O , Compound 58 4-{6-[3-(4-hydroxybutyl)urea]pyrido[2,3-b]pyrazin-3-yl}phenyl 2 methoxyethyl carbonate hydrochloride 15Ho N N H1H x HCI O0 W02007/054556 PCT/EP20061068322 -202 Compound 59 N-(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxalic monoamide ethyl ester N N N H O 0 Compound 60 N-ethyl-N -(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxalamide N N N H o 5 Compound 61 H H OH Compound 62 diethyl {2-[3-(3-phenylpyrido[2, 3-b]pyrazin-6-yl)urea]ethyl} phosphate o N N 0-i N"'.N N N N o H H 10 Compound 63 {2-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]ethyl}phosphoric acid - .N HO HO"- N N N OH H H Compound 64 1-[3-(2-diethylaminoethoxy)propyl]-3-[3-(4-hydroxy-3-methoxy phenyl)pyrido[2,3-b]pyrazin-6-yl]urea o N N N O' H H W02007/054556 PCT/EP2006/068322 - 203 Compound 65 (2,2-dimethylpropionyloxymethoxy)-(4-{3-[3-(4-hydroxy-3-m ethoxy phenyl)pyrido[2,3-b]pyrazin-6-yl]urea)butyl)phosphinoyloxymethyl 2,2-dimethyl propanoate o= OH o o 5 Compound 66 1 -[(1 -acetoxyethoxy)-(4-{3-[3-(4-hydroxy-3-methoxyphenyl) pyrido[2,3-b] pyrazin-6-yl]urea}butyl)phosphinoyloxy]ethyl acetate 0=N N O H H O o o Compound 67 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]2-methoxypheny diethylcarbamate "NN N N H H N 10 Compound 68 2-chloro-4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yI]-6-methoxy phenyl diethylcarbamate N N N N H H O N - Compound 69 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yI]-2-methoxyphenyl 2-[2-(2 15 methoxyethoxy)ethoxy]ethyl carbonate W02007/054556 PCT/EP2006/068322 - 204 N. H H 0 Compound 70 1 -ethyl-3-{3-[4-(morpholine-4-sulfonyl)phenylamino]pyrido[2, 3 b]pyrazin-6-yi~urea 5 Compound 71 ethyl 5-16-(3-ethylureido)pyrido[2,3-b]pyrazin-3-ylaminoj-2-hydroxy be nzoate N~X X C .._ .... Compound 72 1 -[3-(3-diethylaminomethyl-4-hydroxyphenylamino)pyrido[2,3 b] pyrazin-6-yi]-3-ethyl urea 10 Compound 73 1 -ethyl-3-[3-(6-morpholin-4-ylpyridin-3-ylamino)pyrido[2,3-b]pyrazin 6-yI]urea Compound 74 1 -ethyl-3-{3-[3-(1 H-tetrazol-5-yI)phenylamino]pyrido[2,3-b]pyrazin-6 15 yIjurea W02007/054556 PCT/EP2006/068322 - 205 *H' Compound 75 1 -ethyl-3-[3-(3-morpholin-4-yiphenylamino)pyrido[2,3-b]pyrazin-6 yl]urea NN 5 Compound 76 1 -ethyl-3-[3-(4-imidazol-1 -ylphenylamino)pyrido[2,3-b]pyrazin-6 yl]urea .H HX HK Compound 77 1 -ethyl-3-[3-(4-pyrrolidin-1 -ylphenylamino)pyrido[2,3-b]pyrazin-6 yl]urea 10 Compound 78 1 -ethyl-3-{3-[4-(4-methylpiperazn-1 -yl)phenylamino]pyrido[2,3 b]pyrazin-6-y}urea .. ... ...... ,.. Compound 79 1 -ethyl-3-[3-(3-piperidin-1 -ylmethylphenylamino)pyrido[2,3-b]pyrazin 15 6-yl]urea W02007/054556 PCT/EP2006/068322 - 206 Nfl Compound 80 1 -ethyl-3-[3-(4-morpholin-4-ylmethylphenylamino)pyrido[2,3 b]pyrazin-6-yl]urea N NN N H -IH. 5 Compound 81 1-{3-[3-(2-cyclohexylethoxy)phenylamino]pyrido[2,3-b]pyrazin-6-yl} 3-ethylurea -H H H Compound 82 1 -ethyl-3-[3-(3-[1,2,4]triazol-1 -ylmethylphenylamino)pyrido[2,3 b]pyrazin-6-yl]urea FiN 10 Compound 83 2,2-dimethyl[1,3]dioxolan-4-ylmethy 4-{3-[3-(4-hydroxy-3 methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]ureido}buty carbonate 0 0O Compound 84 2,3-dihydroxypropyl 4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3 15 b]pyrazin-6-yl]ureido}butyl carbonate W020071054556 PCT/EP2006/068322 - 207 Compound 85 1-[3-(2-diethylaminoethoxy)propyl]-3-[3-(4-hydroxy-3 methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea O..N....O H H ow. 5 In order to avoid ambiguities: when chemical structure and chemical name of the explicit compounds shown above erroneously do not match one another, the chemical structure shall unambiguously define the particular explicit compound. 10 The generic compounds of the general formulae (1) and (11) shown above, the preferred embodiments and the pyridopyrazine compounds 1 to 85 mentioned explicitly are referred to collectively hereinafter as "inventive compounds". The expressions and terms specified to illustrate the inventive compounds are in principle each defined, unless stated otherwise in the description or in the claims, as 15 follows: In the context of this invention, the expression "alkyl" encompasses acyclic saturated or unsaturated hydrocarbon radicals which may be branched or straight chain and have 1 to 8 carbon atoms, i.e. C 1

-

8 -alkanyls, C 2

-

8 -alkenyls and C 2

-

8 -alkynyls. 20 Alkenyls have at least one C-C double bond and alkynyls at least one C-C triple bond. Alkynyls may additionally also have at least one C-C double bond. Preferred alkyl radicals are methyl, ethyl, n-propyl, 2-propyl, n-butyl, sec-butyl, tert-butyl, n-pentyl, iso pentyl, neo-pentyl, n-hexyl, 2-hexyl, n-heptyl, n-octyl, , n-nonyl, n-decyl, n-undecyl, n dodecyl, ethylenyl (vinyl), ethynyl, propenyl (-CH 2

CH=CH

2 ; -CH=CH-CH 3 , -C(=CH 2

)

25 CH 3 ), propynyl (-CH 2 -C-CH, -C=C-CH 3 ), butenyl, butynyl, pentenyl, pentynyl, hexenyl, hexynyl, heptenyl, heptynyl, octenyl, octadienyl and octynyl.

W020071054556 PCT/EP2006/068322 -208 In the context of this invention, the expression "(C9-C 3 o)alkyl" describes acyclic saturated or unsaturated hydrocarbon radicals which may be branched or straight chain and have 9 to 30 carbon atoms, i.e. C 9

-

30 -alkanyls, Cg- 30 -alkenyls and C9-30 5 alkynyls. C 9

-

30 -Alkenyls have at least one C-C double bond and C 9

-

30 -alkynyls at least one C-C triple bond. Cg- 30 -Alkynyls may additionally also have at least one C-C double bond. Preferred (C 9

-C

3 0 )alkyl radicals are tetradecyl, hexadecyl, octadecyl, eicosanyl, cis-13-docosenyl (erucyl), trans-13-docosenyl (brassidyl), cis-15-tetracosenyl (nervonyl) and trans-15-tetracosenyl. 10 For the purposes of this invention, the expression "cycloalkyl" means cyclic nonaromatic hydrocarbons having 1 to 3 rings with 3 to 20, preferably 3 to 12 carbon atoms, which may be saturated or unsaturated, more preferably (C 3

-C

8 )cycloalkyl. The cycloalkyl radical may also be part of a bi- or polycyclic system, where, for example, 15 the cycloalkyl radical is fused to an aryl, heteroaryl or heterocyclyl radical as defined herein by any possible and desired ring member(s). The bonding to the compounds of the general formulae (I), (II) can be effected via any possible ring member of the cycloalkyl radical. Preferred cycloalkyl radicals are cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclodecyl, cyclohexenyl, cyclopentenyl and 20 cyclooctadienyl. The expression "heterocyclyl" represents a 3- to 14-membered, preferably 3-, 4-, 5-, 6-, 7- or 8-membered, cyclic organic radical which contains at least 1 heteroatom, optionally 2, 3, 4 or 5 heteroatoms, especially nitrogen, oxygen and/or sulphur, the 25 heteroatoms being the same or different and the cyclic radical being saturated or unsaturated but not aromatic. The heterocyclyl radical may also be part of a bi- or polycyclic system, where, for example, the heterocyclyl radical is fused to an aryl, heteroaryl or cycloalkyl radical as defined herein by any possible and desired ring member(s). The bonding to the compounds of the general formulae (1), (II) can be 30 effected via any possible ring member of the heterocyclyl radical. Preferred heterocyclyl radicals are tetrahydrofuryl, pyrrolidinyl, imidazolidinyl, thiazolidinyl, tetrahydropyranyl, piperidinyl, piperazinyl, morpholinyl, thiapyrrolidinyl, oxapiperazinyl, oxapiperidinyl and oxadiazolyl.

W020071054556 PCT/EP2006/068322 - 209 In the context of this invention, the expression "aryl" means aromatic hydrocarbons having 3 to 14 carbon atoms, preferably 5 to 14 carbon atoms, more preferably 6 to 14 carbon atoms. The aryl radical may also be part of a bi- or polycyclic system, where, for 5 example, the aryl radical is fused to a heterocyclyl, heteroaryl or cycloalkyl radical as defined herein by any possible and desired ring member(s), for example to tetrahydrofuran, tetrahydrothiophene, pyrrolidine, imidazolidine, thiazolidine, tetrahydropyran, dihydropyran, piperidine, furan, thiophene, imidazole, thiazole, oxazole, isoxazole. The bonding to the compounds of the general formulae (I), (II) can 10 be effected via any possible ring member of the aryl radical. Preferred aryl radicals are phenyl, biphenyl, naphthyl and anthracenyl, but likewise indanyl, indenyl or 1,2,3,4 tetrahydronaphthyl. The expression "heteroaryl" represents a 5-, 6- or 7-membered cyclic aromatic 15 radical which contains at least 1 heteroatom, if appropriate also 2, 3, 4 or 5 heteroatoms, especially nitrogen, oxygen and/or sulphur, the heteroatoms being the same or different. The number of nitrogen atoms is preferably 0 to 3, that of oxygen and sulphur atoms preferably 0 or 1. The heteroaryl radical may also be part of a bi- or polycyclic system, where, for example, the heteroaryl radical is fused to a heterocyclyl, 20 aryl or cycloalkyl radical as defined herein by any possible and desired ring member(s). The bonding to the compounds of the general formulae (1), (II) can be effected via any possible ring member of the heteroaryl radical. Preferred heteroaryl radicals are pyrrolyl, furyl, thienyl, thiazolyl, isothiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, pyrazolyl, imidazolyl, triazole, tetrazole, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazine, 25 phthalazinyl, indolyl, indazolyl, indolizinyl, quinolinyl, isoquinolinyl, quinoxalinyl, quinazolinyl, pteridinyl, carbazolyl, phenazinyl, phenoxazinyl, phenothiazinyl, and acridinyl. For the purposes of the present invention, the expressions "alkyl-cycloalkyl", 30 "cycloalkylalkyl", "alkyl-heterocyclyl", "heterocyclylalkyl", "alkyl-aryl", "arylalkyl", "alkyl heteroaryl" and "heteroarylalkyl" mean that alkyl, cycloalkyl, heterocycl, aryl and heteroaryl are each as defined above, and the cycloalkyl, heterocyclyl, aryl and W02007/054556 PCT/EP2006/068322 -210 heteroaryl radical is bonded to the compounds of the general formulae (1), (11) via an alkyl radical, preferably Cr-C 8 -alkyl radical, more preferably 0 1

-C

4 -alkyl radical. In connection with "alkyl", "cycloalkyl", "heterocyclyl", "aryl", "heteroaryl", "alkyl 5 cycloalkyl", "alkyl-heterocycyl", "alkyl-aryl" and "alkyl-heteroaryl", the term "substituted" in the context of this invention, unless defined explicitly above in the description or the claims, is understood to mean the substitution of one or more hydrogen radicals by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-Alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , O(-alkyl-O)p-alkyl, O-aryl, OSO 3 H, OP(O)(OH) 2 , OP(O)(OAlkyl) 2 , OP(O)(OAryl) 2 , CHO, 10 C(O)OH, C(O)OR36, C(O)NH 2 , C(O)NHR36, C(O)NR36R37, SO 3 H, SO 2 alkyl, SO 2 aryl,

P(O)(OH)

2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5, and where the R36 and R37 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkyl-cycloalkyl, alkyl-heterocyclyl, alkyl-aryl or alkyl-heteroaryl, and R36 and R37 may 15 together form a heterocyclyl ring. The substituents may be the same or different and the substitution may occur in any desired and possible position of the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl radical. In the context of this invention, the expression "halogen" encompasses the halogen 20 atoms fluorine, chlorine, bromine and iodine. Polysubstituted radicals are understood to mean those which are polysubstituted, for example di- or trisubstituted, either at different atoms or at the same atom, for example trisubstituted on the same carbon atom as in the case of CF 3 , -CH 2

CF

3 or at 25 different positions as in the case of -CH(OH)-CH=CH-CHCl 2 . The polysubstitution can be effected with the same substituent or different substituents. When the inventive compounds have at least one centre of asymmetry, they may be present in the form of their racemates, in the form of the pure enantiomers and/or 30 diastereomers, or in the form of mixtures of these enantiomers and/or diastereomers, and either in substance or as pharmaceutically acceptable salts of these compounds. The mixtures may be present in any desired mixing ratio of the stereoisomers.

W020071054556 PCT/EP2006/068322 -211 For example, the inventive compounds which have one or more centres of chirality and which occur as racemates can be separated by methods known per se into their optical isomers, i.e. enantiomers or diastereomers. The separation can be effected by column separation on chiral phases or by recrystallization from an optically active 5 solvent or using an optically active acid or base or by derivatization with an optically active reagent, for example an optically active alcohol, and subsequent detachment of the radical. The inventive compounds may be present in the form of their double bond isomers 10 as "pure" E or Z isomers, or in the form of mixtures of these double bond isomers. Where possible, the inventive compounds may be present in the form of the tautomers. 15 The inventive compounds may, if they have a sufficiently basic group, for example a primary, secondary or tertiary amine, be converted to their physiologically tolerated salts with inorganic and organic acids. The pharmaceutically acceptable salts of the inventive compounds are preferably formed with hydrochloric acid, hydrobromic acid, sulphuric acid, phosphoric acid, methanesulphonic acid, p-toluenesulphonic acid, 20 carbonic acid, formic acid, acetic acid, trifluoroacetic acid, sulphoacetic acid, oxalic acid, malonic acid, maleic acid, succinic acid, tartaric acid, pyruvic acid, malic acid, embonic acid, mandelic acid, fumaric acid, lactic acid, citric acid, glutamic acid or aspartic acid. The salts formed include hydrochlorides, hydrobromides, sulphates, hydrogensulphates, phosphates, methanesulphonates, tosylates, carbonates, 25 hydrogencarbonates, formates, acetates, triflates, sulphoacetates, oxalates, malonates, maleates, succinates, tartrates, malates, embonates, mandelates, fumarates, lactates, citrates, glutamates and aspartates. The stoichiometry of the salts of the inventive compounds formed may be whole or fractional multiples of one. 30 The inventive compounds may, if they have a sufficiently acidic group, for example the carboxyl group or the phosphoric acid group, be converted to their physiologically tolerated salts with inorganic and organic bases. Examples of useful inorganic bases W020071054556 PCT/EP2006/068322 -212 include sodium hydroxide, potassium hydroxide, calcium hydroxide; examples of useful organic bases include ethanolamine, diethanolamine, triethanolamine, cyclohexylamine, dibenzylethylenediamine and lysine. The stoichiometry of the salts of the inventive compounds formed may be whole or fractional multiples of one. 5 Preference is likewise given to solvates and especially hydrates of the inventive compounds, which can be obtained, for example, by crystallization from a solvent or from aqueous solution. It is possible for one, two, three or as many as possible solvate or water molecules to bond with the inventive compounds to form solvates and 10 hydrates. It is known that chemical substances form solids which are present in various states of order, which are referred to as polymorphic forms or modifications. The physical properties of the different modifications of a polymorphic substance can differ greatly. 15 The inventive compounds may be present in various polymorphic forms; certain modifications may be metastable. It is likewise possible for the inventive compounds to occur in the form of any prodrugs, for example esters, carbonates, carbamates, ureas, amides or phosphates, 20 in which the actually biologically active form is only released by metabolism. It is known that chemical substances are converted to metabolites in the body, which may in some cases likewise cause the desired biological effect - under some circumstances even in more marked form. Corresponding prodrugs and metabolites of the inventive compounds should be 25 considered to be part of the invention. It has now been found in a surprising and advantageous manner that the inventive compounds can also act, i.e. have a modulating or inhibiting effect, on two or more signal transduction pathways or enzymes of such pathways. It has been found that the 30 inventive compounds act, i.e. modulate or inhibit, with high selectivity.

W02007/054556 PCT/EP2006/068322 -213 Such a simultaneous, for example dual, modulation or inhibition of two or more signal transduction pathways, for example ras-Raf-Mek-Erk signal pathway, PI3K-Akt signal pathway and/or SAPK signal pathway, more specifically Erkl/Erk2 and/or P13K and/or Jnk and/or p38, is advantageous over the only single modulation or inhibition of 5 one signal transduction pathway, since synergistic therapeutic effects can be brought about, for example enhanced apoptosis and more rapid and efficient tumour regression. The surprising advantageous effects of the inventive compounds enable multiple therapeutic approaches to be pursued in the physiological and/or pathophysiological 10 states or conditions which are sensitive to the treatment or modulation of, or are mediated by, two or more signal transduction pathways. It has also been found in a surprising and advantageous manner that the inventive compounds can also act, i.e. have modulating or inhibiting action, with high selectivity 15 on the ras-Raf-Mek-Erk signal transduction pathway or enzymes thereof, and that the multiple mechanisms of action and therapeutic approaches detailed above can also find use with this signal pathway or enzymes. It has also been found in a surprising and advantageous manner that the inventive 20 compounds can also act, i.e. have modulating or inhibiting action, with high selectivity on the P13K-Akt signal transduction pathway or enzymes thereof, and that the multiple mechanisms of action and therapeutic approaches detailed above can also find use with this signal pathway or enzymes. 25 It has also been found in a surprising and advantageous manner that the inventive compounds can also act, i.e. have modulating or inhibiting action, with high selectivity on the SAPK signal transduction pathway or enzymes thereof, and that the multiple mechanisms of action and therapeutic approaches detailed above can also find use with this signal pathway or enzymes. 30 It has additionally been found in a surprising and advantageous manner that the inventive compounds can also act, i.e. have a modulating or inhibiting action, with high W02007/054556 PCT/EP2006/068322 -214 selectivity on enzymes such as ATM, ATR, mTOR, DNA-PK and/or hSMG-1, and that the multiple mechanisms of action and therapeutic approaches detailed above can also find use with these enzymes. According to the invention, the term "modulation" is understood to mean the 5 following: "activation, partial activation, inhibition, partial inhibition". It is within the technical knowledge of the average person skilled in the art to measure and to determine such an activation, partial activation, inhibition or partial inhibition by means of the customary measurement and determination methods. For example, a partial activation can be measured and determined in relation to a full activation; and likewise 10 a partial inhibition in relation to a full inhibition. According to the invention, the term "inhibition" is understood to mean the following: "partial or full inhibition". It is within the technical knowledge of the average person skilled in the art to measure and to determine such a partial or full inhibition by means 15 of the customary measurement and determination methods. For example, partial inhibition can be measured and determined in relation to full inhibition. The terms "modulation" and "inhibition" relate, in connection with "enzymes" and/or "kinases" in the context of this invention, both to the inactive form (enzymatically inactive) and/or active form (enzymatically active) of the particular enzyme and/or 20 kinase. This means in the context of this invention that an inventive compound can display its modulating action on the inactive form, active form or both forms of the enzyme and/or kinase. In a further aspect, the object of the invention was surprisingly achieved by the 25 provision of a medicament comprising at least one inventive compound. In a further aspect, the object of the invention was surprisingly achieved by the provision of a medicament comprising at least one inventive compound in combination with at least one further active pharmaceutical ingredient and/or pharmaceutically 30 acceptable carriers and/or excipients.

W02007/054556 PCT/EP2006/068322 -215 In a further aspect, the object of the invention is surprisingly achieved by the provision of a process for producing a medicament, characterized in that one or more inventive compounds are processed, i.e. brought into a therapeutically usable form, with pharmaceutically acceptable carriers and/or excipients to give pharmaceutical 5 formulations. In a further aspect, the object of the invention is surprisingly achieved by the provision of the inventive compounds which can be used as active ingredients in medicaments for modulating misdirected cellular signal transduction processes, especially for influencing 10 the function of active and inactive receptor tyrosine kinases, and also cytoplasmic tyrosine, serine/threonine and lipid kinases, such as c-Raf, B-Raf, Mek, MAPKs, PDGFRbeta, Flt-3, IGF1R, P13K, PKB/Aktl, c-Kit, c-Abl, FGFR1 and KDR. In a further aspect, the object of the invention is surprisingly achieved by providing the 15 inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the treatment or prophylaxis being brought about by modulation of the signal transduction pathway(s) selected from the group consisting of: "ras-Raf-Mek-Erk signal transduction pathway, P13K-Akt signal transduction pathway and/or SAPK signal transduction pathway". 20 In a further aspect, the object of the invention is surprisingly achieved by the provision of the inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states mediated by enzymes selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1" 25 in mammals. In a further aspect, the object of the invention is surprisingly achieved by the provision of the inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, 30 the treatment or prophylaxis being brought about by modification of one or more enzymes selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1".

W02007/054556 PCTIEP2006/068322 -216 In a preferred embodiment, the inventive compounds are provided for use for the production of a medicament for the treatment and/or prophylaxis of physiological and/or pathophysiological states mediated by the ras-Raf-Mek-Erk signal transduction pathway and/or the P13K-Akt signal transduction pathway in mammals, and/or for the 5 production of a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the treatment or prophylaxis being brought about by modulation of the ras-Raf-Mek-Erk signal transduction pathway and of the P13K-Akt signal transduction pathway. 10 In a further aspect, the object of the invention is surprisingly achieved by the provision of the inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states mediated by the ras-Raf-Mek-Erk signal transduction pathway in mammals. 15 In a further aspect, the- object of the invention is surprisingly achieved by the provision of the inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states mediated by the PI3K-Akt signal transduction pathway in mammals. 20 In a further aspect, the object of the invention is surprisingly achieved by the provision of the inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the treatment or prophylaxis being brought about by modulation of the P13K-Akt signal transduction pathway. 25 In a preferred embodiment, the inventive compounds are provided for use for the production of a medicament for the treatment and/or prophylaxis of physiological and/or pathophysiological states mediated by the SAPK signal transduction pathway and/or the P13K-Akt signal transduction pathway in mammals, and/or for the production of a 30 medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the treatment or prophylaxis being brought about by modulation of W02007/054556 PCT/EP2006/068322 -217 the SAPK signal transduction pathway and of the P13K-Akt signal transduction pathway. In a further aspect, the object of the invention is surprisingly achieved by the provision 5 of the inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states mediated by the SAPK signal transduction pathway in mammals. In a further aspect, the object of the invention is surprisingly achieved by the provision 10 of the inventive compounds which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the treatment or prophylaxis being brought about by modulation of the SAPK signal transduction pathway. 15 In a preferred embodiment, the inventive compounds are provided for the uses detailed above, the modulation of the ras-Raf-Mek-Erk signal transduction pathway being brought about by modulation of one or more enzymes selected from the group consisting of: "tyrosine kinase, serine/threonine kinase, receptor tyrosine kinase, cytoplasmic tyrosine kinase, cytoplasmic serine/threonine kinase" and preferably 20 selected from the group consisting of "Erk, Erk1, Erk2". In a further preferred embodiment, the inventive compounds are provided for the use as detailed above, the modulation of the P13K-Akt signal transduction pathway being brought about by modulation of one or more enzymes selected from the group 25 consisting of "lipid kinases" and preferably selected from the group consisting of: "P13K, Pl3Kalpha, P13Kbeta, P13Kgamma, P13Kdelta, P13K-C2alpha, PI3K-C2beta, P13K Vps34p". In a further preferred embodiment, the inventive compounds are provided for the 30 use as detailed above, the modulation of the SAPK signal transduction pathway being brought about by modulation of one or more enzymes selected from the group consisting of: "tyrosine kinase, serine/threonine kinase, receptor tyrosine kinase, W02007/054556 PCT/EP2006/068322 -218 cytoplasmatic tyrosine kinase, cytoplasmatic serine/threonine kinase" and preferably selected from the group consisting of: "Jnk, Jnkl, Jnk2, Jnk3, p38, p38alpha, p38beta, p38gamma, p38delta". 5 In a further aspect, the object of the invention is surprisingly achieved by the provision of the inventive compounds according to the aspects, preferred embodiments and uses detailed above, which can be used to produce a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the treatment or prophylaxis being brought about by modulation of two or more enzymes. 10 In a more preferred embodiment, the inventive compounds are provided for the uses detailed above, at least one enzyme in the treatment or prophylaxis brought about by modulation of two or more enzymes being selected from the group consisting of: "Erk, Erk1, Erk2" and at least one enzyme being selected from the group consisting of: 15 "P13K, P13Kalpha, Pl3Kbeta, Pl3Kgamma, Pl3Kdelta, P13K-C2alpha, PI3K-C2beta, Pl3K-Vps34p". In a more preferred embodiment, the inventive compounds are provided for the uses detailed above, at least one enzyme in the treatment or prophylaxis brought about 20 by modulation of two or more enzymes being selected from the group consisting of: "Jnk, Jnkl, Jnk2, Jnk3, p38, p38alpha, p38beta, p38gamma, p38delta" and at least one enzyme being selected from the group consisting of: "PI3K, Pl3Kalpha, P13Kbeta, Pl3Kgamma, Pl3Kdelta, P13K-C2alpha, PI3K-C2beta, P13K-Vps34p". 25 In a more preferred embodiment, the inventive compounds are provided for the uses detailed above, at least one enzyme in the treatment or prophylaxis brought about by modulation of two or more enzymes being selected from the group consisting of: "Erk, Erk1, Erk2" and at least one enzyme being selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". 30 In a more preferred embodiment, the inventive compounds are provided for the uses detailed above, at least one enzyme in the treatment or prophylaxis brought about W02007/054556 PCT/EP2006/068322 -219 by modulation of two or more enzymes being selected from the group consisting of: "Jnk, Jnkl, Jnk2, Jnk3, p38, p38alpha, p38beta, p38gamma, p38delta" and at least one enzyme being selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". 5 In a more preferred embodiment, the inventive compounds are provided for the uses detailed above, at least one enzyme in the treatment or prophylaxis brought about by modulation of two or more enzymes being selected from the group consisting of: ,,Pl3K, Pl3Kalpha, P13Kbeta, Pl3Kgamma, Pl3Kdelta, PI3K-C2alpha, P13K-C2beta, 10 PI3K-Vps34p" and at least one enzyme being selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". In another preferred embodiment, the inventive compounds are provided for the uses detailed above, the modulation being an inhibition. 15 In the context of this invention, the inventive compounds may be administered to all known mammals, especially to the human, for treatment and/or prophylaxis. In another preferred embodiment, the inventive compounds are provided for the use as detailed above, the mammal being selected from the group consisting of: 20 "humans, useful animals, livestock, domestic pets, beef cattle, cows, sheep, pigs, goats, horses, ponies, donkeys, hinnies, mules, hares, rabbits, cats, dogs, guinea pigs, hamsters, rats, mice" and preferably being a human. In the context of this invention, the inventive compounds may be used for the 25 treatment and/or prophylaxis of all known physiological and/or pathophysiological states. In a preferred embodiment, the inventive compounds are provided for the uses detailed above, the physiological and/or pathophysiological states being selected from the group consisting of: "malignant tumours, benign tumours, inflammatory disorders, 30 inflammations, pain, rheumatic disorders, arthritic disorders, HIV infections, neurological or neurodegenerative disorders, rheumatism, arthritis, AIDS, ARC (AIDS related complex), Kaposi's sarcoma, tumours emanating from the brain and/or nervous system W02007/054556 PCT/EP2006/068322 - 220 and/or meninges, dementia, Alzheimer's, hyperproliferative disorders, psoriasis, endometriosis, scar formation, benign prostate hyperplasia (BPH), disorders of the immune system, autoimmune disorders, immune deficiency disorders, colon tumour, stomach tumour, intestine tumour, lung tumour, pancreas tumour, ovarial tumour, 5 prostate tumour, leukaemia, melanoma, liver tumour, kidney tumour, head tumour, throat tumour, glioma, breast tumour, uterine cancer, endometrial cancer, cervical cancer, brain tumour, adenocanthoma, bladder cancer, stomach tumor, colorectal tumour, oesophageal cancer, gynaecological tumour, ovarian tumour, thyroid cancer, lymphoma, chronic leukaemia, acute leukaemia, restenosis, diabetes, diabetic nephropathy, fibrotic 10 disorders, cystic fibrosis, malignant nephrosclerosis, thrombotic microangiopathy syndrome, organ transplant rejection, glomerulopathies, disorders of the metabolism, solid tumours, rheumatic arthritis, diabetic retinopathy, asthma, allergies, allergic disorders, chronic obstructive pulmonary disorders, inflammatory bowel disorder, fibrosis, atherosclerosis, cardiac disorders, cardiovascular disorders, disorders of the heart 15 muscle, vascular disorders, angiogenetic disorders, kidney disorders, rhinitis, Grave's disease, focal ischaemia, heart failure, ischaemia, cardiac hypertrophy, kidney failure, cardiac myocyte dysfunction, high blood pressure, vascular constriction, stroke, anaphylactic shock, blood platelet agglutination, skeletal muscular atrophy, obesity, excess weight, glucose homeostasis, congestive heart failure, angina, heart attack, 20 myocardial infarction, hyperglycaemia, hypoglycaemia, hypertension". In a further aspect of the present invention, the object of the invention is surprisingly achieved by the provision of the inventive compounds according to the aspects, preferred embodiments and uses detailed above for use for the production of a 25 medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the medicament comprising at least one further pharmacologically active substance. In a further aspect of the present invention, the object of the invention is surprisingly 30 achieved by the provision of the inventive compounds according to the aspects, preferred embodiments and uses detailed above for use for the production of a medicament for the treatment or prophylaxis of physiological and/or pathophysiological W02007/054556 PCT/EP2006/068322 -221 states in mammals, the medicament being administered before and/or during and/or after the treatment with at least one further pharmacologically active substance. In a further aspect of the present invention, the object of the invention is surprisingly 5 achieved by the provision of the inventive compounds according to the aspects, preferred embodiments and uses detailed above for use for the production of a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states in mammals, the medicament being administered before and/or during and/or after the treatment with radiation therapy and/or surgery. 10 In the context of this invention, the inventive compounds may be administered with all known pharmacologically active substances in a combination therapy as detailed. In a preferred embodiment, the inventive compounds are provided for the uses detailed above, the further pharmacologically active substance being selected from the 15 group consisting of: "DNA topoisomerase I and/or II inhibitors, DNA intercalators, alkylating agents, microtubuli destabilizers, hormone and/or growth factor receptor agonists and/or antagonists, antibodies against growth factors and their receptors, kinase inhibitors, antimetabolites". In a preferred embodiment, the inventive compounds are provided for the above 20 uses, the further pharmacologically active substance being selected from the group consisting of: "asparaginase, bleomycin, carboplatin, carmustine, chlorambucil, cisplatin, colaspase, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, doxorubicin (adriamycin), epirubicin, etoposide, 5-fluorouracil, hexamethylmelamine, hydroxyurea, ifosfamide, irinotecan, leucovorin, lomustine 25 mechlorethamine, 6-mercaptopurine, mesna, methotrexate, mitomycin C, mitoxantrone, prednisolone, prednisone, procarbazine, raloxifen, streptozocin, tamoxifen, thioguanine, topotecan, vinblastine, vincristine, vindesine, aminoglutethimide, L-asparaginase, azathioprine, 5-azacytidine cladribine, busulfan, diethylstilbestrol, 2',2'-difluorodeoxycytidine, docetaxel, erythrohydroxynonyladenine, 30 ethynylestradiol, 5-fluorodeoxyuridine, 5-fluorodeoxyuridine monophosphate, fludarabine phosphate, fluoxymesterone, flutamide, hydroxyprogesterone caproate, idarubicin, interferon, medroxyprogesterone acetate, megestrol acetate, melphalan, mitotane, paclitaxel, oxaliplatin, pentostatin, N-phosphonoacetyl-L-aspartate (PALA), W02007/054556 PCT/EP2006/068322 - 222 plicamycin, semustine, teniposide, testosterone propionate, thiotepa, trimethylmelamine, uridine, vinorelbine, epothilone, gemcitabine, taxotere, BCNU, CCNU, DTIC, 5-fluorouarcil, herceptin, avastin, erbitux, sorafenib, gleevec, iressa, tarceva, rapamycin, actinomycin D". 5 The oral administration can be effected, for example, in solid form as a tablet, capsule, gel capsule, coated tablet, granule or powder, but also in the form of a drinkable solution. For oral administration, the novel, inventive compounds as defined above can be combined with known and commonly used, physiologically acceptable carriers and 10 excipients, for example gum arabic, talc, starch, sugar, for example mannitol, methylcelulose, lactose, gelatin, surfactants, magnesium stearate, cyclodextrins, aqueous or nonaqueous carriers, diluents, dispersants, emulsifiers, lubricants, preservatives and flavourings (e.g. essential oils). The inventive compounds may also be dispersed in a microparticulate, for example nanoparticulate, composition. 15 The nonoral administration can be effected, for example, by intravenous, subcutaneous or intramuscular injection of sterile aqueous or oily solutions, suspensions or emulsions, by means of implants or by means of ointments, creams or suppositories. If appropriate, administration can also be effected in sustained-release form. Implants may 20 comprise inert materials, for example biodegradable polymers or synthetic silicones, for example silicon rubber. Intravaginal administration can be effected, for example, by means of vaginal rings. Intrauterine administration can be effected, for example, by means of diaphragms or other suitable intrauterine devices. Additionally envisaged is transdermal administration, especially by means of a formulation suitable therefor and/or 25 suitable means, for example plasters. The inventive medicaments may be administered in a suitable administration form to the skin, epicutaneously as a solution, suspension, emulsion, foam, ointment, paste or plaster; via the oral and lingual mucosa, buccally, lingually or sublingually as a 30 tablet, pastille, coated tablet, linctus or gargle; via the gastric and intestinal mucosa, enterally as a tablet, coated tablet, capsule, solution, suspension or emulsion; via the rectal mucosa, rectally as a suppository, rectal capsule or ointment; via the nasal mucosa, nasally as drops, an ointment or spray; via the bronchial and alveolar W02007/054556 PCT/EP2006/068322 -223 epithelium, pulmonarily or by inhalation as an aerosol or inhalate; via the conjunctiva, conjunctivally as eye drops, eye ointment, eye tablets, lamellae or eyewash; via the mucosa of the genital organs, intravaginally as vaginal suppositories, ointments and douche, intrauterinally as a uterus pessary; via the urinary tract, intraurethrally as an 5 irrigation, ointment or bougie; into an artery, intraarterially as an injection; into a vein, intravenously as an injection or infusion; into the skin, intracutaneously as an injection or implant; under the skin, subcutaneously as an injection or implant; into the muscle, intramuscularly as an injection or implant; into the abdominal cavity, intraperitoneally as an injection or infusion. 10 With regard to practical therapeutic requirements, the medicament action of the inventive compounds can be prolonged by means of suitable measures. This aim can be achieved by a chemical and/or pharmaceutical route. Examples of the achievement of a prolonged action are the use of implants and liposomes, the formation of sparingly 15 soluble salts and complexes, or the use of crystal suspensions. As already explained above, the novel inventive compounds can also be combined with further pharmaceutically active ingredients. In the context of a combination therapy, the individual active constituents can be administered simultaneously or separately, either 20 by the same route (for example orally) or by separate routes (for example orally and as an injection). The may be present or be administered in the same amount or different amounts in a unit dose. It is also possible to employ a certain dosage regime when this appears appropriate. In this way, it is also possible to combine a plurality of the novel inventive compounds with one another. 25 The dosage may vary within a wide range depending on the type of indication, the severity of the disorder, the type of administration, and the age, gender, body weight and the sensitivity of the subject to be treated. It is within the abilities of a person skilled in the art to determine a "pharmacologically active amount" of the combined pharmaceutical composition. The administration can be effected in a single dose or a 30 plurality of separate doses.

W02007/054556 PCT/EP2006/068322 -224 A suitable unit dose is, for example, 0.001 mg to 100 mg of the active ingredient, i.e. of at least one inventive compound and optionally of a further active pharmaceutical ingredient, per kg of body weight of a patient. 5 In a further aspect of the present invention, the present invention accordingly also encompasses pharmaceutical compositions comprising a pharmacologically active amount of at least one inventive compound, preferably compound 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45,46, 47, 48, 49, 50, 51, 52, 53, 54, 10 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84 and/or compound 85, and also optionally pharmaceutically tolerated carriers and/or excipients. Preferred and particularly preferred inventive compositions are those which 15 comprise at least one of the aforementioned preferred inventive compounds. In pharmaceutical compositions according to the present invention, not only at least one inventive compound as defined above but also at least one further pharmaceutically active ingredient as already described in detail above may be present. 20 In the inventive pharmaceutical compositions, at least one of the novel inventive compounds as defined above is present in a pharmacologically active amount, preferably in a unit dose, for example the aforementioned unit dose, and preferably in an administration form which enables oral administration. 25 With regard to the pharmaceutical compositions comprising the inventive compounds, and with regard to the use of the inventive compounds as a medicament, reference is made to the statements already made in connection with the use of the novel inventive compounds themselves with regard to possible uses and administration means. 30 In a further aspect of the present invention, the object of the inventiion is surprisingly achieved by the provision of a kit comprising a pharmacologically active W02007/054556 PCT/EP2006/068322 - 225 amount of at least one preferred inventive compound as detailed above and a pharmacologically active amount of at least one further pharmacologically active ingredient as defined above. 5 General synthesis methods for the inventive compounds The processes for preparing inventive substituted pyrido[2,3-b]pyrazines are illustrated below. The inventive compounds are obtainable according to the following schemes (schemes 1 - 9) and corresponding processes known to those skilled in the art: 10 The definition of the R1 to R36 radicals shown in the following schemes corresponds to the substituents defined above in connection with the general formulae (1) and (1l), for example Z radicals, R radicals, X radicals, T radicals, etc. The individual assignment can be accomplished in a simple manner by the person skilled in the art on the basis of his or her average technical knowledge.

W02007/054556 PCT/EP2006/068322 - 226 Scheme 1 0 1 1 st stage - NO reduction NH2 +R3R4

H

2 N N NH 2

H

2 N N NH2 0 1 2 3 2nd stage N R4

H

2 N N N R3 4 0 0 II 1+ 1st stage ~ - O O O reduction N + R3 R4 NI N H 2 L N 5 6 3 2nd stage H2 NN R4 N R3 7 Precursors for selected examples of the inventive pyrido[2,3-b]pyrazines in which the substituents R2 and R4 are to be substituted by hydrogen are, for example, 5 obtainable by the process in scheme 2 or a corresponding process known to those skilled in the art.

W02007/054556 PCT/EP20061068322 -227 Scheme 2 N 1st stage N

H

2 N N 0 POCl 3

H

2 N N N Cl 8 9 Precursors for selected examples of the inventive pyrido[2,3-b]pyrazines in which the substituents R3 and/or R4 are to be the OR31, SR32, NR33R34 radicals are, for example, obtainable by the process in scheme 3 or a corresponding process known to 5 those skilled in the art.

W02007/054556 PCT/EP2006/068322 -228 Scheme 3 0 H NH1st stage N~cN H2N ; :2 + EtO OEt H1 2 Nsts NtX H 2/6 10 2nd stage POC13 3rd stage N Cl base N 0 3 H N 2N N Cl HOR31 N N2N HSR32 11 HNR33R34 12 N R32

H

2 N N N 13 R Nj N -R34

H

2 N R N X N_ N , 33 14 R For the precursor 11 shown above, the intermediate 22 from scheme 6 or else the intermediates 20, 21, 21a and 21b from scheme 5 may be used. Precursors for selected examples of the inventive pyrido[2,3-b]pyrazines in which 5 the substituent R9 is not to be H are, for example, obtainable by the process in scheme 4 or a corresponding process known to those skilled in the art.

W02007/054556 PCT/EP2006/068322 -229 Scheme 4 N R4 1st stage N R4

H

2 N HN N N R3 R5-Hal R5N N R3 4/7 R5-OTos 15 The precursors 4, 7, 9 and 15 from schemes 1-4 can be converted to the inventive substituted pyrido[2,3-b]pyrazines, for example, by the process in scheme 5 or a corresponding process known to those skilled in the art.

W020071054556 PCT/EP2006/068322 - 230 Schema 5 1st stage N R4 R7-N--=0 N R4 R5 N N R3 H R5 N R3 4/7/9/15 16 phosgene or O N R4 carbonyldiimidazole R7N.kI1<1N R ,I I A NH R R5 N N R3 or R8 17 R7 0 N 0 N R4 I H P5 N N R3 17 R7 -N hS P7NfR4 H PS N' NT R 18 thiophosgene or thiocarbonyldiimidazole S N R4 N N R 7 , I I A NH R R5 N N P3 I RB RS R8 19 W02007/054556 PCT/EP2006/068322 - 231 Scheme 5 1st stage R4 phosgene + R9N O1 N R4 ZZH RiO ~N- 4I HN -R10 N NC R5 N N'R3 or R | 0 R9 R5 N N R3 4/7/9/15 0 N RO1 20 R9 R11 phosgene + R9, NNR10 R1 0 N R4 H IN R10' N+ R9 R5 N N R3 N NR1 21 R9 0 C C0 N R4 R10'ONfR Ri0-OH 0 R5 N N R3 21a 0 0 CI O CI R1 0 r O R0N N R4 R10sNH 0 R5 N N R3 R1 21b HR10 R11 ON R4 N R4 R i I0 R5 N N R3 0 R5 N N R3 21 b 21a Selected examples of the inventive pyrido[2,3-b]pyrazines in which the substituents R3 and/or R4 may be selected substituted aryl, heteroaryl, alkyl, alkenyl or alkynyl radicals are, for example, obtainable by the process in scheme 6 or corresponding processes 5 known to those skilled in the art.

W02007/054556 PCT/EP2006/068322 -232 Scheme 6 1st stage O/S O/S R7 N CI N N aryl, HAr R8 R5 N N or HAr-X R8 R5 N N 22 23 R ZnBr N R - NN N R8 R5 N N 23a O/S ____R7,) N 'I, N N,, R R NNR R8 R5 N N X = -B(OR) 2 , - 3 24 Y = H, -B(OR) 2 , -SnR 3 O/S R = alkyl, aryl, HAr, etc. - N N __ R R8 R5 N N 25 Selected examples of the inventive pyrido[2,3-b]pyrazines in which the substituents R3 and/or R4 are -N-C(O)-, -N-SO 2 -, -N-C(O)-0- and -N-C(O)-N- are, for example, obtainable by the process in scheme 7 or corresponding processes known to those 5 skilled in the art.

W02007/054556 PCT/EP20061068322 -233 Scheme 7 1st stage O/S O/S R7 NNH2 CI R26 R7 N N N _ Jci I 12 R8 R5 N N R8 R5 N N 22 26 2nd stage oo , O/S 0 NI N N R7 .N 'ci' R26 R7,, Ik N R26 R8 R5 N NR8 R5 N N R24 26 0o O/S O0 CI R26 R7 N R26 S I- NR26 R8 R5 N N R24 28 0 O/S O o N'R26 R7 , Nk Nj )k .:R26 N N 0 R8 R5 N N R24 29 0/S 0 ,:;-,NR27 R7,, N NR27KN R8 R5 N N R24 R28 or CI N R730 Selected examples of the inventive pyrido[2,3-b]pyrazines in which the substituents R3 and/or R4 may be selected urea-, carbamate- or carbonate-substituted radicals are, 5 for example, obtainable by the process in scheme 8 or corresponding processes known to those skilled in the art.

W02007/054556 PCT/EP2006/068322 -234 Scheme 8 1st stage 0 R19 R7 CA R19 R7 8 5 N R8 R5 NN R8 R5 N N 32 31 C N- 0 R18 R18 R7, N N O R18 or N R8 R5 N 33 0 0 R19 R7 8 R1-CRO19 R7.8, N R18 I 14 ~ N NNR8R R8 R5 N N R18RB 5N 35 34 N'R18 O 718 C R 18 WR, N N- & N R18R1 or BNR8 R5 N N R 36 Selected examples of the inventive pyrido[2,3-b]pyrazines in which the substituents R3 and/or R4 may be selected 0-, S-, N-substituted radicals are, for example, obtainable by the process in scheme 9 or corresponding processes known to those 5 skilled in the art. Scheme 9 1st stage 0 NR50N/R3 RN. N- N.R 5 R.). N- (4 ' R8 R5 N N Y e.g.C Br,I R8 R5 N N 37 38 X = OH. SH, NHR36 X = 0. S, NR36 The starting compounds and intermediates are either commercially available or can be prepared by procedures known per se or known to those skilled in the art. The W02007/054556 PCT/EP2006/068322 -235 reactants 4, 7, 9-15, 22, 26, 31, 34 and 37 are valuable intermediates for the preparation of the inventive pyridopyrazines. For the preparation of the starting compounds, intermediates and the inventive pyridopyrazines, reference is made inter alia to the patents WO 2004/104002 and 5 WO 2004/104003, and also, for example, to the following primary literature whose contents are hereby incorporated into the disclosure of the present application: 1) Houben-Weyl, Methoden der Organischen Chemie, volume 4/1a, pp 343-350 2) Houben-Weyl, Methoden der Organischen Chemie, 4th ed., volume E 7b (part 2), 10 p. 579; Degussa GB 1184848 (1970); S. Seko, et al. EP 735025 (1996) 3) D. Catarzi, et al.; J. Med. Chem. 1996, 1330-1336; J. K. Seydel, et.al.; J. Med. Chem. 1994, 3016-3022 4) Houben-Weyl, Methods of Organic Chemistry, Volume E 9c, pp.231-235 5) Houben-Weyl/Science of Synthesis, Volume 16, p. 1269 15 6) C. L. Leese, H. N. Rydon J. Chem. Soc. 1955, 303-309; T. S. Osdene, G. M. Timmis J. Chem. Soc. 1955, 2033-2035 7) W. He, et al. Bioorg. Med. Chem. Lett. 2003, 13, 3097-3100 8) M. S. A. El-Gaby, et al. Indian J. Chem. Sect. B 2001, 40, 195- 200; M. R. Myers, et al. Bioorg. Med. Chem. Lett. 2003, 13, 3091-3096; A. R. Renslo, et al. J. Amer. 20 Chem. Soc. 1999, 121, 7459-7460; C. 0. Okafor, et al. J. Heterocyclic Chem. 1983, 20, 199-203; C. R. Hopkins, et al. Tet. Lett. 2004, 45, 8631-8633 9) J. Yin, et al. Org. Lett. 2002, 4, 3481-3484; 0. A. E-Sayed, et al. Arch. Pharm. 2002, 335, 403-410 ; C. Temple, et al. J. Med. Chem. 1992, 35, 988-993 10) A. M. Thompson, et al. J. Med. Chem. 2000, 43, 4200-4211; N. A. Dales, et al. Org. 25 Lett. 2001, 2313-2316; G. Dannhardt, et al. Arch. Pharm. 2000, 267-274; G. S. Poindexter, et al. Bioorg. Med. Chem. 2004, 12, 507-521; J.-M. Receveur, et al. Bioorg. Med. Chem. Lett. 2004, 14, 5075-5080 11) G. Heinisch, et al. Arch. Pharm. 1997, 207-210; K. Matsuno, et al. J. Med. Chem. 2002, 45, 4513-4523; A. M. Papini, et al. J. Med. Chem. 2004, 47, 5224-5229 W02007/054556 PCT/EP20061068322 - 236 12) J. Mindi, et al. Collect. Czech. Chem. Commun. 1983, 48, 900-905; S. Sasaki, et al. J. Med. Chem. 2003, 46, 113-124; B.-B. Zeng, et al. Bioorg. Med. Chem. Lett. 2004, 14, 5565-5568 13) Q. Wang, et al. Synthetic Commun. 2004, 34, 255-264 ; W. Mederski, et al. Bioorg. 5 Med. Chem. Lett. 2003, 13, 13715-3718 ; R. J. Brown, et al. Tetrahedron 2004, 60, 4361-4375 14) L. Mao, et al. Synthesis 2004, 15, 2535-2539; M. Darabantu, et al. Tetrahedron 2005, 61, 2897-2905; E. Ford, et al. Tet. Lett. 2000, 41, 3197-3198; T. Shiota, et al. J. Org. Chem. 1999, 64, 453-457; E. C. Taylor, et al. Synthetic Commun. 1987, 10 17, 1865-1868; G. A. Molander, et al. J. Org. Chem. 2002, 67, 8424-8429; G. Hughes, et al. Org. & Biomolecular Chem. 2004, 2, 3363-3367 15) R. P. Tangallapally, et al. J. Med. Chem. 2004, 47, 5276-5283; R. H. Bradburry, et al. J. Med. Chem. 1997, 40, 996-1004 16) X. He, et al. Bioorg. Med. Chem. 2004, 12, 4003-4008; A. Gopalsamy, et al. Bioorg. 15 Med. Chem. Lett. 2005, 15, 1591-1594; J.-F. Cheng, et al. Bioorg. Med. Chem. Lett. 2004, 14, 2411-2416; E. R. Parmee, et al. Bioorg. Med. Chem. Lett. 2004, 14, 43-46 17) G. Yang, et al. Synthetic Commun. 2006, 36, 5611-5619; H. B. Woo, et al. Bioorg. Med. Chem. Lett. 2005, 15, 3782-3786. 20 18) J. F. Miravet, et al. Org. Lett. 2005, 7, 4791-4794; A. L. Castelhano, et al. Bioorg. Med. Chem. Lett. 2005, 15, 1501-1504. 19) Y. Lu, et al. Bioorg. Med. Chem. Lett. 2006, 16, 915-919; J. W. Szewczyk, et al. Bioorg. Med. Chem. Lett. 2006, 16, 3055-3060.

W02007/054556 PCT/EP2006/068322 - 237 General methods for the preparation of the inventive compounds: Scheme 1: 1st stage 5 2,6-Diamino-3-nitropyridine or 2-amino-3,5-dinitropyridine are dissolved in a suitable inert solvent, for example methanol, ethanol, dimethylformamide or dioxane. After adding a catalyst, for example Raney nickel, palladium on carbon or platinum(IV) dioxide, the reaction mixture is placed under a hydrogen atmosphere, and a pressure between 1 and 5 bar is established. The reaction mixture is allowed to react for several 10 hours, for example 1-16 hours, within a temperature range between 20*C and 60*C. Once the reaction has ended, the insoluble residues are filtered off, for which the filter medium may consist of silica gel, Celite or commercial glass fibre filters, and they are washed with the appropriate solvent. The crude product, present in solution, is used for the next reaction without further purification. 15 2nd stage The 1,2-dione derivative is initially charged in a suitable inert solvent, for example methanol, ethanol, dioxane, toluene or dimethylformamide. 2,3,6-Triaminopyridine or 20 2,3,5-triaminopyridine, directly after the reduction, as a solution of the crude products in one of the abovementioned solvents, are added to the initially charged 1,2-dione, optionally with addition of an acid, for example acetic acid or a base, for example potassium hydroxide. The reaction mixture is allowed to react within a temperature range of 20*C to 80*C for a certain time, for example 20 minutes to 40 hours. Once the 25 reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of solvent under reduced pressure. When dimethylformamide is used, the reaction mixture is stirred into a large amount of water and the precipitated solid is 30 filtered off, or the aqueous phase is extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phases are concentrated under reduced pressure. The remaining crude product is purified by recrystallization W02007/054556 PCT/EP2006/068322 - 238 from a suitable solvent, for example dioxane, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 5 Scheme 2: 1st stage The pyridopyrazinone derivative 8 is initially charged in a suitable inert solvent, for example dimethylformamide, dioxane or toluene, or without solvent. A chlorinating agent, for example phosphoryl chloride or thionyl chloride, is added at room 10 temperature and the reaction mixture is allowed to react within a temperature range of from 20 0 C to 1 00*C for a certain time, for example 1 hour to 24 hours. Once the reaction has ended, the reaction mixture is poured onto water and neutralized with a suitable aqueous base, for example sodium hydroxide solution. Any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter 15 paper, and washed with the appropriate solvent, and the remaining residue is dried under reduced pressure, or the aqueous phase is extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phases are concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example dioxane or toluene, or by column 20 or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. Scheme 3: 1st stage 25 2,3,6-Triaminopyridine or 2,3,5-triaminopyridine are, directly after the reduction, as a solution of the crude products, initially charged in one of the abovementioned solvents. After an oxalic acid derivative has been added, for example diethyl oxalate or oxalyl chloride, the reaction mixture, optionally with addition of an acid, for example hydrochloric acid, sulphuric acid or glacial acetic acid, is allowed to react within a 30 temperature range of 20 0 C to 1500C for a certain time, for example 10 minutes to 24 hours. After the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with W02007/054556 PCT/EP2006/068322 -239 the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous 5 base, for example sodium hydroxide solution, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example dioxane or toluene, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a 10 mixture of methanol and dichloromethane. 2nd stage The dione derivative 10 is initially charged in a suitable inert solvent, for example 15 dimethylformamide, dioxane or toluene, or without solvent. A chlorinating agent, for example phosphoryl chloride or thionyl chloride, is added at room temperature and the reaction mixture is allowed to react within a temperature range of from 20*C to 100*C for a certain time, for example 1 hour to 24 hours. Once the reaction has ended, the reaction mixture is poured onto water and neutralized with a suitable aqueous base, for 20 example sodium hydroxide solution. Any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining residue is dried under reduced pressure, or the aqueous phase is extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phases are concentrated under 25 reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example dioxane or toluene, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 30 3rd stage W02007/054556 PCT/EP2006/068322 -240 The intermediate 11 can be reacted with an appropriate alcohol, thiol or amine and optionally with a suitable base, preferably sodium hydride, pyridine, triethylamine, potassium carbonate or sodium methoxide in methanol, in a suitable inert solvent, for example dimethylformamide, dimethyl sulphoxide, methanol, toluene, or in a base as 5 the solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 30 minutes to 2 days, in a temperature range between 20 0 C and 1400C. Alternatively, the intermediate 11 can be reacted with an appropriate amine and a suitable catalyst, for example tris(dibenzylideneacetone)dipalladium(0) or tetrakis(triphenylphosphine)palladium(0), 10 and a suitable ligand, for example 2-(dicyclohexylphosphanyl)biphenyl, and a suitable base, for example sodium tert-butoxide, in a suitable solvent, for example toluene or dimethylformamide. The reaction mixture is allowed to react for a certain time, for example 2 hours to 30 hours, in a temperature range between 60*C and 1200C. After the reaction has ended, any precipitated solid is filtered off, for which the filter medium 15 may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for 20 example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example dioxane, ethyl acetate or toluene, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of 25 methanol and dichloromethane. Scheme 4: 1st stage The intermediates 4 and 7 can be reacted with an appropriate, suitable chloride, 30 bromide or tosylate and optionally with a suitable base, for example sodium hydride, pyridine, triethylamine, potassium carbonate or sodium methoxide in methanol, in a suitable inert solvent, for example dimethylformamide, dimethyl sulphoxide, methanol, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The W02007/054556 PCT/EP2006/068322 -241 reaction mixture is allowed to react for a certain time, for example 1 hour to 24 hours, in a temperature range between 20*C and 1500C. Alternatively, the intermediates 4 and 7 can be reacted with an appropriate aryl bromide or iodide and a suitable catalyst, for example palladium acetate or Pd 2 (dba) 3 , and a suitable ligand, for example BINAP, and 5 a suitable base, for example potassium carbonate or sodium tert-butoxide, in a suitable solvent, for example toluene or dioxane. The reaction mixture is allowed to react for a certain time, for example 10 hours to 30 hours, in a temperature range between 600C and 120 0 C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with 10 the appropriate solvent, and the remaining solid is dried under reduced pressure, or any catalyst residues are filtered off and washed with the appropriate solvent, and the solvent is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, 15 after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or toluene, or by column or flash chromatography on silica gel or alumina. The eluent 20 used is, for example, a mixture of methanol and dichloromethane. Scheme 5: 1st stage After the basic process, the products formed by the basic process can be converted 25 in conversion reactions to inventive conversion products in a procedure known to the person skilled in the art. For instance, when the product is to be a derivative of compound 16 according to scheme 5, the reaction product 4, 7, 9 or 15 can be reacted with an appropriate 30 isocyanate and optionally a suitable base, preferably sodium hydride, potassium hexamethyldisilazide, pyridine, triethylamine or potassium carbonate, in a suitable inert solvent, for example dimethylformamide, dimethyl sulphoxide, acetonitrile, dichloromethane, 1,2-dichlorethane or dioxane, or in a base as the solvent, for example W02007/054556 PCT/EP2006/068322 -242 pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for several hours, for example 1 - 24 hours, within a temperature range between 0 and 80*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the 5 appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, 10 for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 15 Or, alternatively, when the product is to be a derivative of compound 17 according to scheme 5, the reaction product 4, 7, 9 or 15 may be reacted with phosgene or carbonyldiimidazole and an appropriate amine in a suitable inert solvent, for example dimethylformamide, tetrahydrofuran, toluene, dichloromethane or acetonitrile. If 20 appropriate, a suitable base, preferably pyridine, sodium hydrogencarbonate, triethylamine, N-methylmorpholine or sodium acetate, is used. The reaction mixture is allowed to react for a certain time, for example 15 minutes to 24 hours, in a temperature range between 0 and 60*C. Alternatively, the reaction product 4, 7, 9 or 15 can be reacted with an appropriate amine-phenyl-carbamate reagent and optionally 25 with a suitable base, preferably pyridine, sodium carbonate, triethylamine or sodium hydride, in a suitable inert solvent, for example tetrahydrofuran, dioxane, dichloromethane, dimethylformamide or acetonitrile, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 1 hour to 18 hours, within a temperature range 30 between 0*C and 120 0 C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water W02007/054556 PCT/EP2006/068322 - 243 and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified 5 by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. For instance, when the product is to be a derivative of compound 18 according to 10 scheme 5, the reaction product 4, 7, 9 or 15 can be reacted with an appropriate isothiocyanate and appropriately a suitable base, preferably sodium hydride, triethylamine, potassium carbonate or pyridine, in a suitable inert solvent, for example dimethylformamide, tetrahydrofuran, acetone or toluene, or in a base as a solvent, for example, pyridine or triethylamine, or without solvent. The reaction mixture is allowed 15 to react for a certain time, for example 30 minutes to 90 hours, within a temperature range between 0 and 1150C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced 20 pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified 25 by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. Or, alternatively, when the product is to be a derivative of the compound 19 30 according to scheme 5, the reaction product 4, 7, 9 or 15 can be reacted with thiophosgene or thiocarbonyldiimidazole and an appropriate amine in a suitable inert solvent, for example dimethylformamide, tetrahydrofuran, toluene, dichloromethane, ethanol or acetonitrile. Optionally, a suitable base, preferably pyridine, sodium W02007/054556 PCT/EP2006/068322 -244 hydrogencarbonate, potassium carbonate, triethylamine or imidazole is used. The reaction mixture is allowed to react for several hours, for example 1 to 24 hours, in a temperature range between -10 and 800C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of 5 commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be 10 extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 15 For instance, when the product is to be a derivative of compound 20 according to scheme 5, the reaction product 4, 7, 9 or 15 can be reacted with phosgene or carbonyldiimidazole and an appropriate hydroxylamine in a suitable inert solvent, for example dimethylformamide, tetrahydrofuran, dioxane, dichloromethane or toluene. 20 Optionally, a suitable base, preferably pyridine, sodium carbonate, triethylamine or sodium acetate, is used. The reaction mixture is allowed to react for a certain time, for example 1 hour to 24 hours, within a temperature range between 0 and 1000C. Alternatively, the reaction product 4, 7, 9 or 15 can be reacted with an appropriate hydroxylamine-phenyl-carbamate reagent and optionally with a suitable base, 25 preferably pyridine, sodium carbonate, triethylamine or sodium acetate, in a suitable inert solvent, for example tetrahydrofuran, dioxane, dichloromethane, dimethylformamide or toluene, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 1 hour to 18 hours, within a temperature range between room 30 temperature and 100*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water W02007/054556 PCT/EP2006/068322 -245 and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified 5 by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. For instance, when the product is to be a derivative of compound 21 according to 10 scheme 5, the reaction product 4, 7, 9 or 15 can be reacted with phosgene or carbonyldiimidazole and an appropriate hydrazine in a suitable inert solvent, for example dioxane, chloroform, toluene or ethanol. Optionally, a suitable base, preferably pyridine, sodium carbonate, diisopropyliethylamine or sodium acetate, is used. The reaction mixture is allowed to react for a certain time, for example 1 hour to 15 24 hours, within a temperature range between 0 and 100 0 C. Alternatively, the reaction product 4, 7, 9 or 15 can be reacted with an appropriate hydrazine-phenyl-carbamate reagent and optionally with a suitable base, preferably pyridine, sodium carbonate, triethylamine or sodium acetate, in a suitable inert solvent, for example tetrahydrofuran, dioxane, dichloromethane, dimethylformamide or toluene, or in a base as a solvent, for 20 example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 1 hour to 15 hours, within a temperature range between 0*C and 100 C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under 25 reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic 30 phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane.

W02007/054556 PCT/EP2006/068322 -246 Or, alternatively, when the product is to be a derivative of the compound 21 a according to scheme 5, the reaction product 4, 7, 9 or 15 can be reacted with oxalyl chloride and an appropriate alcohol, optionally with a suitable base, preferably pyridine, sodium hydroxide, triethylamine, in a suitable inert solvent, for example 5 tetrahydrofuran, toluene, dichloromethane, ethanol, or in a base as a solvent, for example pyridine or triethylamine. The reaction mixture is allowed to react for a certain time, for example 15 minutes to 24 hours, with in a temperature range between -10 and 60*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with 10 the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, 15 for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 20 Or, alternatively, when the product is to be a derivative of the compound 21 b according to-scheme 5, the reaction product 4, 7, 9 or 15 can be reacted with oxalyl chloride or ethyloxalyl chloride and an appropriate amine, optionally with a suitable base, preferably pyridine, sodium hydroxide, triethylamine, in a suitable inert solvent, 25 for example tetrahydrofuran, toluene, dichloromethane, ethanol, or in a base as a solvent, for example pyridine or triethylamine. The reaction mixture is allowed to react for a certain time, for example 15 minutes to 24 hours, with in a temperature range between -10 and 600C. Alternatively, the intermediate 21a can be reacted with an appropriate amine, optionally with a suitable base, preferably pyridine, sodium hydride 30 or triethylamine, in a suitable inert solvent, for example tetrahydrofuran, toluene, dichloromethane, ethanol, or in a base as a solvent, for example pyridine or triethylamine. The reaction mixture is allowed to react for a certain time, for example 1 hour to 50 hours, within a temperature range between 10 and 1200C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may W02007/054556 PCT/EP2006/068322 - 247 consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed of the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid can be 5 filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash 10 chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. Scheme 6: 1st stage 15 After the basic process, the products formed by the basic process can be converted to inventive conversion products in conversion reactions in a procedure known to those skilled in the art. For instance, when the product is to be a derivative of compound 23 according to 20 scheme 6, the reaction product 22 can be reacted with appropriate aryl/heteroarylboronic acid derivatives or aryl/heteroarylorganotin compounds and a suitable catalyst, for example Pd(PPh 3

)

4 , [1,1'-bis(diphenylphosphino)ferrocene] dichloropalladium(II) or Pd 2 (dba) 3 , and a suitable base, for example sodium carbonate, caesium carbonate or triethylamine, in a suitable solvent, for example 25 dimethylformamide, dimethylformamide/water, toluene, acetonitrile, dimethoxyethane or dioxane. The reaction mixture is allowed to react for a certain time, for example 6 hours to several days, within a temperature range between 600C and 1200C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate 30 solvent, and the remaining solid is dried under reduced pressure, or any catalyst residues present are filtered off and washed with the appropriate solvent, and the solvent is removed under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a W02007/054556 PCT/EP2006/068322 - 248 large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude 5 product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. For instance, when the product is to be a derivative of the compound 23a according 10 to scheme 6, the reaction product 22 can be reacted with appropriate alkylzinc halides and a suitable catalyst, for example Pd(PPh 3

)

4 , [1,1'-bis(diphenylphosphino)ferrocene] dichloropalladium(II) or PdC 2 (PPh 3

)

2 in a suitable solvent, for example dimethylformamide, tetrahydrofuran, toluene, dimethoxyethane or dioxane. The reaction mixture is allowed to react for a certain time, for example 30 minutes to 15 48 hours, within a temperature range between room temperature and 120 0 C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or any catalyst residues present are filtered off and washed with the appropriate solvent, and the 20 solvent is removed under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining 25 crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. For instance, when the product is to be a derivative of the compound 24 according 30 to scheme 6, the reaction product 22 can be reacted with appropriate vinylboronic acid derivatives, vinylorganotin compounds or alkene derivatives and a suitable catalyst, for example Pd(PPh 3

)

4 , [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(ll) or Pd(OAc) 2 , and a suitable ligand, for example triphenylphosphine or tri-o-tolylphosphine, W02007/054556 PCT/EP2006/068322 -249 and a suitable base, for example potassium carbonate, sodium carbonate, triethylamine or sodium acetate, in a suitable solvent, for example toluene, dimethylformamide, dimethylformamide/water, acetonitrile, dimethoxyethane or dimethylacetamide. The reaction mixture is allowed to react for a certain time, for 5 example 3 hours to 24 hours, within a temperature range between 60*C and 140*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or any catalyst residues present are filtered off and washed with the appropriate solvent, and 10 the solvent is removed under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl 15 acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or toluene, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 20 For instance, when the product is to be a derivative of compound 25 according to scheme 6, the reaction product 22 can be reacted with appropriate alkyne derivatives and a suitable catalyst, for example Pd(PPh 3

)

4 , PdCl 2 (PPh 3

)

2 or Pd 2 (dba) 3 , and a suitable additive, for example copper(l) iodide, and a suitable base, for example potassium carbonate, triethylamine or potassium acetate, in a suitable solvent, for 25 example dimethylformamide, tetrahydrofuran, tetrahydrofuran/water, toluene or dimethylacetamide. The reaction mixture is allowed to react for a certain time, for example 1 hour to several days, within a temperature range between room temperature and 1200C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with 30 the appropriate solvent, and the remaining solid is dried under reduced pressure, or any catalyst residues present are filtered off and washed with the appropriate solvent, and the solvent is removed under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the W02007/054556 PCT/EP2006/068322 -250 aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable 5 solvent, for example ethanol or toluene, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 10 Scheme 7: 1st stage After the basic process, the products formed by the basic process can be converted to inventive conversion products in conversion reactions in a procedure known to those 15 skilled in the art. The intermediate 22 can be reacted with an appropriate amine and optionally with a suitable base, preferably sodium hydride, pyridine, triethylamine, potassium carbonate or sodium methoxide in methanol, in a suitable inert solvent, for example 20 dimethylformamide, dimethyl sulphoxide, methanol, toluene, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 1 hour to several days, within a temperature range between 20 0 C and 140 0 C. Alternatively, the intermediate 22 can be reacted with an appropriate amine and a suitable catalyst, for example palladium 25 acetate or Pd 2 (dba) 3 , and a suitable ligand, for example BINAP, and a suitable base, for example potassium carbonate or sodium tert-butoxide, in a suitable solvent, for example toluene or dioxane. The reaction mixture is allowed to react for a certain time, for example 10 hours to 30 hours, in a temperature range between 600C and 120*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter 30 medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or any catalyst residues present are filtered off and washed with the appropriate solvent, and W02007/054556 PCT/EP2006/068322 -251 the solvent is removed under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, 5 can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example dioxane, ethyl acetate or toluene, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 10 2nd stage For instance, when the product is to be a derivative of compound 27 according to 15 scheme 7, the reaction product 26 can be reacted with an appropriate carbonyl chloride and optionally a suitable base, preferably sodium hydride, potassium hydroxide, pyridine, triethylamine or potassium carbonate, and optionally a catalyst, for example dimethylaminopyridine, in a suitable inert solvent, for example tetrahydrofuran, toluene, acetonitrile, dichloromethane, acetone or dioxane, or in a 20 base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture can be reacted for a certain time, for example 30 minutes to 24 hours, within a temperature range between 0 and 110*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining 25 solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for.example dichloromethane or ethyl acetate, 30 and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane.

W02007/054556 PCT/EP2006/068322 - 252 For instance, when the product is to be a derivative of the compound 28 according to scheme 7, the reaction product 26 can be reacted with an appropriate sulphonyl chloride and optionally a suitable base, preferably sodium hydride, potassium 5 hydroxide, pyridine, triethylamine or potassium carbonate, and optionally a catalyst, for example dimethylaminopyridine, in a suitable inert solvent, for example tetrahydrofuran, toluene, acetonitrile, dichloromethane, acetone, dimethylformamide or dioxane, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 10 30 minutes to 16 hours, within a temperature range between 0 and 1200C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction 15 mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable 20 solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. For instance, when the product is to be a derivative of the compound 29 according 25 to scheme 7, the reaction product 26 can be reacted with an appropriate chlorocarbonic ester and optionally a suitable base, preferably sodium hydride, sodium hydroxide, pyridine, triethylamine or potassium carbonate, and optionally a catalyst, for example dimethylaminopyridine, in a suitable inert solvent, for example dioxane, tetrahydrofuran, dichloromethane, acetone, dimethylformamide or dichloroethane, or in 30 a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 1 hour to 24 hours, within a temperature range between -10 OC and 100*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the W02007/054556 PCT/EP2006/068322 - 253 remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, 5 can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 10 For instance, when the product is to be a derivative of the compound 30 according to scheme 7, the reaction product 26 can be reacted with an appropriate isocyanate or carbamoyl chloride and optionally a suitable base, preferably sodium hydride, pyridine, triethylamine, piperidine or potassium carbonate, and optionally a catalyst, for example dimethylaminopyridine, in a suitable inert solvent, for example dioxane, 15 tetrahydrofuran, dimethylformamide, toluene or acetonitrile, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 2 hours to 40 hours, within a temperature range between room temperature and 100*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for 20 example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, 25 can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 30 Schema 8: 1st stage W02007/054556 PCT/EP2006/068322 - 254 After the basic processes, the products formed by the basic process can be converted to inventive conversion products in conversion reactions in a procedure known to those skilled in the art. 5 For instance, when the product is to be a derivative of the compound 32 or 35 according to scheme 8, the reaction product 31 or 34 can be reacted with an appropriate chlorocarbonic ester and optionally a suitable base, preferably sodium hydride, sodium hydroxide, pyridine, triethylamine or potassium carbonate, and optionally a catalyst, for example dimethylaminopyridine, in a suitable inert solvent, for 10 example dioxane, tetrahydrofuran, dichloromethane, acetone, dimethylformamide or dichloroethane, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 1 hour to 24 hours, within a temperature range between -1 OOC and 100C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may 15 consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example 20 hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and 25 dichloromethane. For instance, when the product is to be a derivative of the compound 33 oder 36 according to scheme 8, the reaction product 31 or 34 can be reacted with an appropriate isocyanate or carbamoyl chloride and optionally a suitable base, preferably 30 sodium hydride, pyridine, triethylamine, piperidine or potassium carbonate, and optionally a catalyst, for example dimethylaminopyridine, in a suitable inert solvent, for example dioxane, tetrahydrofuran, dimethylformamide, toluene or acetonitrile, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The W02007/054556 PCT/EP2006/068322 - 255 reaction mixture is allowed to react for a certain time, for example 2 hours to 40 hours, within a temperature range between room temperature and 100*C. Once the reaction has ended, any precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and 5 the remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example 10 dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example ethanol or ethyl acetate, or by column or flash chromatography on silica gel or alumina. The eluent used is, for example, a mixture of methanol and dichloromethane. 15 Scheme 9: 1st stage After the basic processes, the products formed by the basic process can be converted to inventive conversion products in conversion reactions in a procedure 20 known to those skilled in the art. For instance, when the product is to be a derivative of the compound 38 according to scheme 9, the reaction product 37 can be reacted, for example, with an appropriate chloride, bromide or iodide and optionally with a suitable base, preferably sodium 25 hydride, pyridine, triethylamine, potassium carbonate or sodium methoxide in methanol, in a suitable inert solvent, for example dimethylformamide, dimethyl sulphoxide, methanol, dioxane, tetrahydrofuran, toluene, or in a base as a solvent, for example pyridine or triethylamine, or without solvent. The reaction mixture is allowed to react for a certain time, for example 30 minutes to 2 days, in a temperature range 30 between 00C and 1400C. Alternatively, an amino-substituted intermediate 37 can be reacted, for example, with an appropriate chloride, bromide or iodide and a suitable catalyst, for example tris(dibenzylideneacetone)dipalladium(0) or tetrakis(triphenylphosphine)palladium(0), and a suitable ligand, for example W02007/054556 PCT/EP20061068322 -256 2-(dicyclohexylphosphanyl)biphenyl, and a suitable base, for example sodium tert butoxide, in a suitable solvent, for example toluene or dimethylformamide. The reaction mixture is allowed to react for a certain time, for example 2 hours to 30 hours, within a temperature range between 600C and 120*C. Once the reaction has ended, any 5 precipitated solid is filtered off, for which the filter medium may consist, for example, of commercial filter paper, and washed with the appropriate solvent, and the remaining solid is dried under reduced pressure, or the reaction mixture is freed from the solvent under reduced pressure. Alternatively, the reaction mixture can be stirred into a large amount of water and the precipitated solid filtered off, or the aqueous phase, after 10 neutralization with a suitable aqueous acid, for example hydrochloric acid, can be extracted with a suitable organic solvent, for example dichloromethane or ethyl acetate, and the organic phase concentrated under reduced pressure. The remaining crude product is purified by recrystallization from a suitable solvent, for example dioxane, ethyl acetate or toluene, or by column or flash chromatography on silica gel or alumina. 15 The eluent used is, for example, a mixture of methanol and dichloromethane. Under some of the reaction conditions specified, OH, SH and NH 2 groups may possibly enter into undesired side reactions. It is therefore preferred to provide them with protecting groups or, in the case of NH 2 , to replace it with NO 2 , and then to 20 eliminate the protecting group or to reduce the NO 2 group. For instance, in a modification of the above-described processes, at least one OH group in the starting compounds can be replaced, for example, by a benzyloxy group, and/or at least one SH group can be replaced, for example, by an S-benzyl group and/or at least one NH 2 group can be replaced, for example, by an NH-benzyl group or by an NO 2 group. 25 Subsequently, at least one - preferably all - benzyloxy group(s) or NH-benzyl group(s) can be eliminated, for example, with hydrogen and palladium on carbon, and/or at least one - preferably all - S-benzyl group(s) can be eliminated, for example, with sodium in ammonia, and/or at least one - preferably all - NO 2 group(s) can be reduced, for example, with hydrogen and Raney nickel to NH 2 . 30 Under some of the reaction conditions mentioned, OH, NH 2 and COOH groups may possibly enter into undesired side reactions. It is therefore preferred to convert starting compounds and intermediates which contain at least one OH group and/or at least one W02007/054556 PCT/EP2006/068322 - 257 NH 2 group and/or at least one COOH group to corresponding carboxylic ester and carboxamide derivatives. In a modification of the above-described processes, starting compounds and intermediates which have at least one OH group and/or which have at least one NH 2 group can be converted to carboxylic ester or carboxamide derivatives 5 by reaction with an activated carboxylic acid group, for example a carbonyl chloride group. In a modification of the above-described processes, starting compounds and intermediates which contain at least one COOH can be converted to carboxylic ester or carboxamide derivatives by reaction with an activating agent, for example thionyl chloride or carbonyldiimidazole, and subsequent reaction with a suitable alcohol or 10 amine. Subsequently, at least one - preferably all - carboxylic ester or carboxamide group(s) in the starting compounds and intermediates can be detached, for example, with dilute aqueous acids or bases, in order to release one - preferably all - OH group(s) and/or NH 2 group(s) and/or COOH group(s). 15 The inventive compounds and especially compounds 1 to 85 were named with the AutoNom 2000 software (ISIS TM/ Draw 2.5; MDL). The invention will be illustrated in detail with reference to the examples which follow, but without being restricted to these examples.

W02007/054556 PCT/EP2006/068322 -258 Examples 1) Preparation of inventive compounds The general synthesis methods which are based on the synthesis schemes 1 - 9 5 were used to synthesize the following inventive compounds. In addition, their NMR spectroscopy data and mass spectrometry data and melting points are included. The precursors used for the preparation of the inventive compounds can - unless stated otherwise - be synthesized by processes known to those skilled in the art. The chemicals and solvents used were obtained commercially from the 10 conventional suppliers (Acros, Aldrich, Fluka, Lancaster, Maybridge, Merck, Sigma, TCI, etc.) or synthesized. Example 1: 1-Ethyl-3-(3-phenylethynylpyrido[2,3-b]pyrazin-6-yl)urea (compound 1) 15 Preparation of 1-(3-chloropyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (reaction according to scheme 5) 100 mg of 3-chloropyrido[2,3-b]pyrazin-6-ylamine (0.55 mmol) were initially charged in 5 ml of pyridine and 44 pl of ethyl isocyanate (0.55 mmol) were added at room 20 temperature. The mixture was left to stir at 750C for 3 h and then another 132 pl in total of ethyl isocyanate (1.65 mmol) were added to the reaction mixture is small portions over 18 h. The solvent was then removed under reduced pressure. The resulting solid was purified by means of column chromatography on silica gel (dichloromethane/methanol eluent). This gave a bright yellow solid. 25 Preparation of 1 -ethyl-3-(3-phenylethynylpyrido[2,3-b]pyrazin-6-yl)urea (reaction according to scheme 6) 98.1 mg of 1-(3-chloropyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (0.39 mmol), 10.1 mg copper(l) iodide (0.05 mmol) and 193 pl of triethylamine (1.38 mmol) were initially 30 charged in 2 ml of anhydrous dimethylformamide under nitrogen as a protective gas. - W02007/054556 PCT/EP2006/068322 -259 Subsequently, 29.1 mg of dichlorobis(triphenylphosphine)palladium(ll) (0.04 mmol) and 54 pl of phenylacetylene (0.49 mmol) were added, and the mixture was stirred at room temperature for 16 h. For workup, the mixture was diluted with dichloromethane and added to dilute hydrochloric acid. The precipitated solid was filtered off with suction, 5 and the organic phase was washed with dilute hydrochloric acid and distilled water. After phase separation, the organic solvent was removed under reduced pressure. The further purification was effected by column chromatography on silica gel (dichloromethane/methanol eluent). This gave a yellow solid. Melting point: 236-238*C (decomp.) 10 ESI-MS: found m/z = 318.0 (M + H*); calc. 317 amu 'H NMR (de-DMSO): S = 1.20 (t, 3H), 3.35 - 3.45 (m, 2H), 7.51 - 7.59 (m, 3H), 7.68 (d, 1H), 7.75 (d, 2H), 8.37 (d, 1H), 9.01 (s, 1H), 9.14 (s, 1H), 10.23 (s, 1H) ppm. The following examples were synthesized in accordance with Example 1 and the 15 general synthesis methods: Example 2: 1-Ethyl-3-(3-thiophen-3-ylethynylpyrido[2,3-b]pyrazin-6-yl)urea (compound 2) 20 m.p.: 239-242 OC (decomp.) ESI-MS: found m/z = 324.2 (M + H*); calc. 323 amu 'H NMR (d 6 -DMSO): S = 1.20 (t, 3H), 3.25 - 3.35 (m, 2H), 7.43 (d, 1H), 7.66 (d, 1H), 7.76 (dd, 1H), 8.21 (d, 1H), 8.36 (d, 1H), 8.97 (s, 1H), 9.14 (s, 1H), 10.23 (s, 1H) ppm. 25 Example 3: 1-(3-Cyclopropylethynylpyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (compound 3) m.p.: 227-228 *C (decomp.) ESI-MS: found m/z = 282.3 (M + H*); calc. 281 amu W02007/054556 PCT/EP2006/068322 -260 'H NMR (d 6 -DMSO): 5 = 1.00- 1.10 (m, 2H), 1.19 (t, 3H), 1.69- 1.79 (m, 1H), 3.25 3.35 (m, 2H), 7.63 (d, 1H), 8.32 (d, 1H), 8.77 (s, 1H), 9.11 (s, 1H), 10.18 (s, 1H) ppm. Example 4: 5 1-[3-(3-Dimethylaminoprop-1-ynyl)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea (compound 4) ESI-MS: found m/z = 299.2 (M + H+); calc. 298 amu 'H NMR (d 6 -DMSO): 5 = 1.19 (t, 3H), 2.33 (s, 6H), 3.27 - 3.35 (m, 2H), 3.67 (s, 2H), 7.67 (d, 1H), 8.34 (d, 1H), 8.85 (s, 1H), 9.05 (s, 1H), 10.19 (s, 1H) ppm. 10 Example 5: 1-[3-((E)-2-Cyclohexylvinyl)pyrido[2,3-b]pyrazin-6-y]-3-ethylurea (compound 5) Preparation of 1-[3-((E)-2-cyclohexylvinyl)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea 15 (reaction according to scheme 6) 99.6 mg of 1-(3-chloropyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (0.40 mmol), 73.6 mg of cyclohexylvinylboronic acid (0.48 mmol), 84.4 mg of sodium carbonate (0.80 mmol) and 33.4 mg of [1,1'-bis(diphenylphosphino)ferrocenedichloropalladium(II) (0.04 mmol) were initially charged in 6 ml of dimethylformamide/water (1:1) under 20 nitrogen. The mixture was then heated to 90 0 C for 6.5 h. Distilled water was then added to the reaction mixture and the resulting precipitate was filtered off with suction. The further purification was effected by column chromatography on silica gel (ethyl acetate/heptane eluent mixture). A light brown solid was obtained. m.p.: 202-204 *C (decomp.) 25 ESI-MS: found m/z = 326.0 (M + H*); calc. 325 amu 'H NMR (d 6 -DMSO): 6 = 1.10 - 1.40 (m, 8H), 1.65 - 1.90 (m, 5H), 2.28 - 2.38 (m, 1 H), 3.25 - 3.35 (m, 2H), 6.69 (d, 1H), 7.15 (dd, 1H), 7.58 (d, 1H), 8.28 (d, 1H), 8.98 (s, 1H), 9.15 (s, 1H), 10.05 (s, 1H) ppm.

W02007/054556 -261- PCT/EP2006/068322 The following examples were synthesized according to Example 5 and the general synthesis methods: Example 6: 5 1-Ethyl-3-[3-((E)-3-methoxypropenyl)pyrido[2,3-b]pyrazin-6-yllurea (compound 6) ESI-MS: found m/z = 288.3 (M + H*); calc. 287 amu 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.25 - 3.35 (m, 2H), 3.39 (s, 3H), 4.25 (d, 2H), 6.92 (d, 1H), 7.15 - 7.25 (m, 1H), 7.62 (d, 1H), 8.30 (d, 1H), 9.02 (s, 1H), 9.15 (s, 1H), 10 10.10 (s, 1H) ppm. Example 7: 1-Ethyl-3-{3-[(E)-2-(4-fluorophenyl)vinyl]pyrido[2,3-b]pyrazin-6-yl~urea (compound 27) 15 m.p.: 217-2 19 *C ESI-MS: found m/z = 338.2 (M + H*); calc. 337 amu 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.25 - 3.38 (m, 2H), 7.10 (t, 2H), 7.32 (dd, 2H), 7.54 (d, 1H), 7.61 (d, 1H), 7.87 (t, 2H), 8.02 (d, 1H), 8.31 (d, 1H), 9.09 (s, 1H), 9.17 (bs, 1H), 10.09 (s, 1H) ppm. 20 Example 8 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl methyl carbonate (compound 9) Preparation of 1-ethyl-3-[3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea (reaction 25 according to scheme 5) 0.50 g of 4-(6-aminopyrido[2,3-b]pyrazin-3-yl)phenol (2.10 mmol) were initially charged in 5.0 ml of pyridine. 183 pl of ethyl isocyanate (2.31 mmol) were added dropwise at room temperature and the mixture is heated to 70 - 800C for 2 h. Thereafter, another 183 pl of ethyl isocyanate were added and the mixture was heated to 70 -80*C for a W02007/054556 PCT/EP2006/068 322 - 262 further 2 h. Once the reaction had ended, the reaction mixture was added to ice-water and neutralized with 1 N hydrochloric acid. The precipitated product was filtered off with suction and dried. The product which had been filtered was partly dissolved in ethanol and admixed with 52 mg of potassium hydroxide (0.93 mmol), dissolved in water. The 5 mixture was heated to 400C for approx. 1 h. Thereafter, the reaction solution was neutralized with 1 N hydrochloric acid and the solvent was removed under reduced pressure. The resulting solid was purified by column chromatography on silica gel (dichloromethane/methanol eluent). This gave a yellow solid. 10 Preparation of 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny methyl carbonate (reaction according to scheme 8) 100 mg of 1-ethyl-3-[3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea (0.32 mmol), 30 pl of methyl chloroformate (0.39 mmol) and 45 pl of triethylamine (0.32 mmol) were initially charged in 10 ml of anhydrous dioxane and heated to 100*C for 1 h. After 15 cooling, the precipitated solid was filtered off with suction and dried. Recrystallization from ethanol afforded a pale yellow solid. m.p.: 243-245 *C ESI-MS: found m/z = 368.2 (M + H*); calc. 367 amu 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.30 - 3.39 (m, 2H), 3.90 (s, 3H), 7.49 (d, 2H), 20 7.70 (d, 1H), 8.38 (d, 1H), 8.42 (d, 2H), 9.03 (s, 1H), 9.47 (s, 1H), 10.09 (s, 1H) ppm. The following examples were synthesized according to Example 8 and the general synthesis methods: 25 Example 9: 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl (2-methoxyethyl) carbonate (compound 10) m.p.: 230-232 0C 30 ESI-MS: found m/z = 412.2 (M + H*); calc. 411 amu W02007/054556 PCT/EP2006/06832 2 - 263 1 H NMR (d 6 -DMSO): S = 1.20 (t, 3H), 3.30 - 3.39 (m, 5H), 3.68 (t, 2H), 4.40 (t, 2H), 7.50 (d, 2H), 7.70 (d, 1H), 8.38 (d, 1H), 8.41 (d, 2H), 9.10 (s, 1H), 9.50 (s, 1H), 10.15 (s, 1H) ppm. 5 Example 10: 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl phenyl carbonate (compound 11) ESI-MS: found m/z = 430.2 (M + H*); calc. 429 amu 1 H NMR (d 6 -DMSO): S = 1.21 (t, 3H), 3.30 - 3.33 (m, 2H), 7.33 - 7.38 (m, 1 H), 7.43 (d, 10 2H), 7.51 (t, 2H), 7.65 (d, 2H), 8.39 (d, 1H), 8.45 (d, 2H), 9.11 (s, 1H), 9.50 (s, 1H), 10.19 (s, 1H) ppm. Example 11: 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl diethylcarbamate (compound 12) 15 ESI-MS: found m/z = 409.4 (M + H 4 ); calc. 408 amu 'H NMR (d 6 -DMSO): S = 1.15 (t, 3H), 1.20 (t, 3H), 1.24 (t, 3H), 3.30 - 3.39 (m, 4H), 3.45 (q, 2H), 7.37 (d, 2H), 7.69 (d, 1H), 8.34 - 8.39 (m, 3H), 9.11 (s, 1H), 9.48 (s, 1H), 10.15 (s, 1H) ppm. 20 Example 12: 3-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyI 2-methoxyethyl carbonate (compound 16) 25 ESI-MS: found m/z = 412.2 (M + H*); calc. 411 amu 'H NMR (d 6 -DMSO): S = 1.20 (t, 3H), 3.33 - 3.38 (m, 5H), 3.63-3.66 (m, 2H), 4.37-4.39 (m, 2H), 7.48 (d, 2H), 7.68 (t, 1H), 7.72 (d, 1H), 8.22 (s, 1H), 8.29 (d, 1H), 8.39 (d, 1H), 9.06 (s, 1H), 9.48 (s, 1H), 10.14 (s, 1H) ppm.

W02007/054556 PCT/EP2006/06832 2 - 264 Example 13: 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl isobutyl carbonate (compound 17) 5 ESI-MS: found m/z = 410.3 (M + H*); calc. 409 amu 'H NMR (d 6 -DMSO): 8 = 0.97 (d, 6H), 1.20 (t, 3H), 2.02 (sep, 1H), 3.25 - 3.38 (m, 2H), 4.06 (d, 2H), 7.50 (d, 2H), 7.70 (d, 1H), 8.38 (d, 1H), 8.41 (d, 2H), 9.10 (s, 1H), 9.47 (s, 1H), 10.14 (s, 1H) ppm. 10 Example 14: But-2-ynyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl carbonate (compound 18) ESI-MS: found m/z = 406.1 (M + H*); calc. 405 amu 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 1.89 (t, 3H), 3.25 - 3.38 (m, 2H), 4.90 (q, 2H), 15 7.50 (d, 2H), 7.70 (d, 1H), 8.38 (d, 1H), 8.41 (d, 2H), 9.09 (s, 1H), 9.47 (s, 1H), 10.14 (s, 1H) ppm. Example 15: 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl dimethylcarbamate (compound 19) 20 Example 15 was prepared using sodium hydride as the base and dimethylformamide as the solvent. m.p.: > 230 *C (decomp.) ESI-MS: found m/z = 381.2 (M + H*); calc. 380 amu 25 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 2.95 (s, 3H), 3.09 (s, 3H), 3.25 - 3.38 (m, 2H), 7.37 (d, 2H), 7.68 (d, 1H), 8.35-8.38 (m, 3H), 9.11 (s, 1H), 9.46 (s, 1H), 10.12 (s, 1H) ppm.

W02007/054556 -265- PCT/EP2006/068322 Example 16: 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl)-2-methoxyphenyl 2-methoxyethyl carbonate (compound 32) 5 ESI-MS: found m/z = 442.3 (M + H'); calc. 441 amu 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.25 - 3.38 (m, 5H), 3.62 (dd, 2H), 3.97 (s, 3H), 4.35 (dd, 2H), 7.45 (d, 1H), 7.74 (d, 1H), 7.97 (d, 1H), 8.06 (s, 1H), 8.39 (d, 1H), 8.99 (bs, 1H), 9.52 (s, 1H), 10.15 (s, 1H) ppm. 10 Example 17: 2-Benzyloxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyI carbonate (compound 33) ESI-MS: found m/z = 488.2 (M + H*); calc. 487 amu 15 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.28 - 3.38 (m, 2H), 3.75 (t, 2H), 4.43 (t, 2H), 4.57 (s, 2H), 7.31 (t, 1H), 7.36-7.40 (m, 4H), 7.48 (d, 2H), 7.70 (d, 1H), 8.38 (d, 1H), 8.41 (d, 2H), 9.09 (bs, 1H), 9.47 (s, 1H), 10.13 (s, 1H) ppm. Example 18: 20 2-Benzyloxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]-2-methoxyphenyl carbonate (compound 34) m.p.: 172-174 *C ESI-MS: found m/z = 518.3 (M + H*); calc. 517 amu 25 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.28 - 3.38 (m, 2H), 3.74 (dd, 2H), 3.96 (s, 3H), 4.41 (dd, 2H), 4.56 (s, 2H), 7.31 (t, 1H), 7.35-7.40 (m, 3H), 7.44 (d, 2H), 7.74 (d, 1H), 7.97 (d, 1H), 8.06 (s, 1H), 8.39 (d, 1H), 8.99 (bs, 1H), 9.51 (s, 1H), 10.14 (s, 1H) ppm. Example 19: W02007/054556 -266- PCT/EP2006/06832 2 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]-2-methoxyphenyl diethylcarbamate (compound 67) m.p.: 220-222 *C 5 ESI-MS: found m/z = 439.3 (M + H*); calc. 438 amu 'H NMR (d 6 -DMSO): S = 1.13 (t, 3H), 1.20 (t, 3H), 1.24 (t, 3H), 3.28 - 3.36 (m, 4H), 3.44 (q, 2H), 3.94 (s, 3H), 7.31 (d, 1H), 7.73 (d, 1H), 7.94 (d, 1H), 8.01 (s, 1H), 8.37 (d, 1H), 8.97 (bs, 1H), 9.50 (s, 1H), 10.11 (s, 1H) ppm. 10 Example 20: 2-Chloro-4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]-6-methoxyphenyI diethylcarbamate (compound 68) m.p.: 237-239 C 15 ESI-MS: found m/z = 473.4 (M + H*); calc. 472 amu 'H NMR (d 6 -DMSO): S = 1.14 (t, 3H), 1.19 (t, 3H), 1.27 (t, 3H), 3.25-3.38 (m, 4H), 3.46 (q, 2H), 3.97 (s, 3H), 7.76 (d, 1H), 8.00 (s, 1H), 8.09 (s, 1H), 8.39 (d, 1H), 8.94 (bs, 1H), 9.55 (s, 1H), 10.13 (s, 1H) ppm. 20 Example 21: 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]-2-methoxyphenyl 2-[2-(2-methoxyethoxy) ethoxy]ethyl carbonate (compound 69) m.p.: 166-167 OC 25 ESI-MS: found m/z = 530.2 (M + H*); calc. 529 amu 1 H NMR (d 6 -DMSO): S = 1.20 (t, 3H), 3.25 (s, 3H), 3.28-3.35 (m, 2H), 3.45 (t, 2H), 3.53 3.60 (m, 6H), 3.71 (t, 2H), 3.98 (s, 3H), 4.35 (t, 2H), 7.45 (d, 1H), 7.74 (d, 1H), 7.96 (d, 1H), 8.06 (s, 1H), 8.39 (d, 1H), 8.96 (bs, 1H), 9.51 (s, 1H), 10.12 (s, 1H) ppm.

W020071054556 PCT/EP2006/068322 - 267 Example 22: 4-[6-(3-Ethylurea)pyrido[2,3-b] pyrazin-3-yl]phenyl (E)-3-phenylacrylate (compound 13) Preparation of 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl (E)-3-phenylacrylate 5 38.9 mg of 1-ethyl-3-[3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl urea (0.13 mmol) were initially charged in 3.0 ml of dried pyridine. 17.5 mg of dimethylaminopyridine (0.14 mmol) and 22.9 mg of trans-cinnamyl chloride (0.13 mmol) were added at room temperature and the reaction mixture was stirred at room temperature. After 3 h, another 22.9 mg of trans-cinnamyl chloride (0.13 mmol) were added and the mixture 10 was stirred at room temperature for a further 3 h. For workup, the reaction mixture was poured onto ice-water and neutralized with 1 N hydrochloric acid. The precipitated solid was filtered off with suction and dried under reduced pressure. Without further purification, the product obtained was a yellow solid. m.p.: 236-238 *C 15 ESI-MS: found m/z = 440.3 (M + H*); calc. 439 amu 1 H NMR (d 6 -DMSO): 5 = 1.20 (t, 3H), 3.25 - 3.40 (m, 2H), 6.95 (d, 1H), 7.46 - 7.51 (m, 5H), 7.70 (d, 1H), 7.83 - 7.87 (m, 2H), 7.94 (d, 1H), 8.38 (d, 1H), 8.43 (d, 2H), 9.12 (s, 1H), 9.49 (s, 1H), 10.19 (s, 1H) ppm. 20 Example 23: 4-[6-(3-Ethylurea)pyrido(2,3-b]pyrazin-3-yl]phenyl nonadecanoate (compound 14) Preparation of 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny nonadecanoate 50.0 mg of 1-ethyl-3-[3-(4-hydroxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea (0.16 mmol) 25 were initially charged in 5.0 ml of dried pyridine. 19.7 mg of dimethylaminopyridine (0.16 mmol) and 51.2 mg of nonadecanoyl chloride (0.16 mmol) were added at room temperature and the reaction mixture is stirred at room temperature for 4 h. For workup, the reaction mixture was added to approx. 200 ml of distilled water. The precipitated solid was filtered off with suction and washed with water. Column 30 chromatography purification of the crude product on silica gel (dichloromethane/methanol eluent) afforded a white solid.

W02007/054556 PCT/EP2006/068322 - 268 m.p.: 147.2 *C 'H NMR (d 6 -DMSO): 8 = 0.90 (t, 3H), 1.20 - 1.50 (m, 33H), 1.75 - 1.85 (m, 2H), 2.60 2.68 (m, 2H), 3.50 - 3.60 (m, 2H), 7.26 - 7.36 (m, 3H), 8.25 - 8.31 (m, 3H), 8.71 (s, 1 H), 9.22 (s, 1 H), 9.75 (s, 1 H) ppm. 5 Example 24: 1-(3-Benzylpyrido[2,3-b]pyrazin-6-yl]-3-ethylurea (compound 15) Preparation of 1-(3-benzylpyrido[2,3-b]pyrazin-6-yl]-3-ethylurea (reaction according to 10 scheme 6) 2.4 ml of a 0.5 M solution of benzylzinc bromide (1.20 mmol) in THF and 24.7 mg of tetrakis(triphenylphosphine)palladium(O) (0.02 mmol) were initially charged in 1 ml of dioxane under nitrogen. Subsequently, 102.4 mg of 1-(3-chloropyrido[2,3-b]pyrazin- 6 yl)-3-ethylurea (0.41 mmol) and 1 ml of dioxane were added in portions. The mixture 15 was then heated to 100*C. After 7 h, the reaction mixture was allowed to cool and then saturated ammonium chloride solution was added. The aqueous phase was extracted repeatedly with dichloromethane and the collected organic phases were washed with saturated sodium chloride solution, dried over sodium sulphate and freed from the solvent under reduced pressure. Column chromatography purification on silica gel 20 (dichloromethane/methanol eluent) afforded a yellow solid. ESI-MS: found m/z = 308.3 (M + H*); calc. 307 amu 'H NMR (d 6 -DMSO): 8 = 1.19 (t, 3H), 3.25 - 3.35 (m, 2H), 4.35 (s, 2H), 7.25 (t, 1H), 7.30 - 7.39 (m, 4H), 7.64 (d, 1H), 8.32 (d, 1H), 8.77 (s, IH), 9.05 (s, 1H), 10.08 (s, 1H) ppm. 25 Example 25: 1-Methoxy-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea (compound 7) Preparation of 3-phenylpyrido[2,3-b]pyrazin-6-ylamine (reaction according to 30 scheme 6) W02007/054556 PCT/EP2006/068322 -269 1.00 g of 3-chloropyrido[2,3-b]pyrazin-6-ylamine (5.54 mmol), 743 mg of phenylboronic acid (6.09 mmol), 640 mg of tetrakis(triphenylphosphine)palladium(O) (0.55 mmol) and 1.76 g of sodium carbonate (16.6 mmol) were initially charged in 100 ml of dimethylformamide/water (1:1) under nitrogen as a protective gas and stirred at 800C 5 for 2 h. Once the reaction had ended, the mixture was filtered off with suction and the filtrate was poured onto 800 ml of distilled water. The aqueous phase was extracted repeatedly with ethyl acetate. The organic phase was freed of solvents under reduced pressure. The resulting solid was purified by means of column chromatography on silica gel (dichloromethane/methanol eluent). This gave a yellow solid. 10 Preparation of 1-methoxy-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea (reaction according to scheme 5) 100 mg of 3-phenylpyrido[2,3-b]pyrazin-6-ylamine (0.45 mmol) were dissolved in pyridine and admixed with 191 mg of p-nitrophenyl N-methoxycarbamate (0.90 mmol). 15 The mixture was heated under reflux for 4 h. For workup, the pyridine was removed under reduced pressure, and the residue was partitioned in ethyl acetate and distilled water. The phases were separated and the aqueous phase was extracted twice with ethyl acetate. The combined organic phases were dried over MgSO 4 and the solvent was removed under reduced pressure. The residue was purified by column 20 chromatography on silica gel (dichloromethane/methanol eluent). A light beige solid was isolated. ESI-MS: found m/z = 296.2 (M + H*); calc. 295 amu 'H NMR (d 6 -DMSO): 5 = 3.75 (s, 3H), 7.58 - 7.65 (m, 3H), 8.03 (s, 1H), 8.36 (d, 2H), 8.45 (d, 1H), 9.52 (s, 1H), 10.16 (s, 1H), 11.01 (s, 1H) ppm. 25 The following examples were synthesized according to Example 25 and the general synthesis methods: Example 26: 30 1-Allyloxy-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea (compound 8) ESI-MS: found m/z = 322.2 (M + H*); calc. 321 amu WO2007/054556 PCT/EP2006/068322 - 270 1 H NMR (d 6 -DMSO): S = 4.44 (d, 2H), 5.33 (d, 1H), 5.41 (d, 1H), 6.02 -6.10 (m, 1H), 7.58 - 7.65 (m, 3H), 8.00 (s, 1H), 8.36 (d, 2H), 8.45 (d, 1H), 9.52 (s, 1H), 10.13 (s, 1H), 11.07 (s, 1H) ppm. 5 Example 27: 1-[4-(tert-ButyldimethylsiIanyloxy)butyl]-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea (compound 36) ESI-MS: found m/z = 452.6 (M + H*); calc. 451 amu 10 1 H NMR (DMSO-d 6 ) 8 = 0.02 (s, 6H), 0.84 (s, 9H), 1.62-1.65 (m, 4H), 3.30-3.33 (m, 2H), 3.66-3.69 (m, 2H), 7.59-7.62 (m, 3H), 7.64 (d, 1 H), 8.35 (d, 2H), 8.38 (d, 1 H), 9.37 (s, 1H), 9.47 (s, 1H), 10.15 (s, 1H) ppm. Example 28: 15 1-[4-(tert-Butyldimethylsilanyloxy)butyl]-3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[ 2 ,3 b]pyrazin-6-yl]urea (compound 37) ESI-MS: found m/z = 498.5 (M + H*); calc. 497 amu 1 H NMR (DMSO-d 6 ) 6 = 0.01 (s, 6H), 0.83 (s, 9H), 1.61-1.66 (m, 4H), 3.30-3.33 (m, 20 2H), 3.65-3.68 (m, 2H), 3.93 (s, 3H), 6.96 (d, 1H), 7.59 (d, 1H), 7.86 (dd, 1H), 7.92 (d, 1H), 8.32 (d, 1H), 9.29 (s, 1H), 9.42 (s, 1H), 9.73 (s, 1H), 10.08 (s, 1H) ppm. Example 29: Diethyl {4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butylphosphonate (compound 42) 25 ESI-MS: found m/z = 458.2 (M + H*); calc. 457 amu 1 H NMR (DMSO-d 6 ) 8 = 1.16 (t, 6H), 1.59-1.69 (m, 4H), 1.77-1.84 (m, 2H), 3.33-3.36 (m, 2H), 3.90-3.99 (m, 4H), 7.58-7.63 (m, 3H), 7.68 (d, 1H), 8.36 (d, 2H), 8.38 (d, 1H), 9.22 (s, 1H), 9.47 (s, 1H), 10.16 (s, 1H) ppm.

W02007/054556 -271- PCT/EP2006/068322 Example 30: Diethyl (4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[ 2 ,3-b]pyrazin-6 yl]urea}butyl)phosphonate (compound 44) 5 ESI-MS: found m/z = 504.5 (M + H*); calc. 503 amu 1 H NMR (DMSO-d 6 ) S = 1.15 (t, 6 H), 1.58-1.69 (m, 4H), 1.76-1.82 (m, 2H), 3.30-3.33 (m, 2H), 3.89-3.97 (m, 7H), 6.97 (d, 1H), 7.63 (d, 1H), 7.86 (dd, 1H), 7.91 (d, 1H), 8.32 (d, 1H), 9.13 (s, 1H), 9.41 (s, 1H), 9.71 (s, 1H), 10.07 (s, 1H) ppm. 10 Example 31: 1 -Methoxy-3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea (compound 61) 15 ESI-MS: found m/z = 342.3 (M + H*); calc. 341 amu 1 H NMR (d 6 -DMSO): S = 3.74 (s, 3H), 3.93 (s, 3H), 6.98 (d, 1H), 7.87 (dd, 1H), 7.91 (d, 1H), 8.02 (d, 1H), 8.39 (d, 1H), 9.46 (s, 1H), 9.74 (s, 1H), 10.03 (s, 1H), 10.84 (s, 1H) ppm. 20 Example 32: Diethyl {2-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]ethyl phosphonate (compound 62) ESI-MS: found m/z = 430.1 (M + H*); calc. 429 amu 'H NMR (d 6 -DMSO): S = 1.21 (t, 6H), 2.08-2.14 (m, 2H), 3.48-3.55 (m, 2H), 3.98-4.08 25 (m, 4H), 7.58-7.63 (m, 3H), 7.72 (d, 1H), 8.35 (d, 2H), 8.39 (d, 1H), 9.14 (s, 1H), 9.47 (s, 1H), 10.22 (s, 1H) ppm. Example 33: W02007/054556 -272- PCT/EP2006/068322 4-[3-(3-Phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyI ethylcarbamate (compound 38) Preparation of 1-(4-hydroxybutyl)-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea 360 mg (0.22 mmol) of 1-[4-(tert-butyldimethylsilanyloxy)butyl]-3-(3-phenylpyrido[ 2

,

3 5 b]pyrazin-6-yl)urea were dissolved in 20 ml of dichloromethane and admixed with 5 ml of a 2 molar isopropanolic HCI solution. After stirring at room temperature for 12 h, the reaction mixture was washed with water and dried (Na 2

SO

4 ). Removal of the solvent under reduced pressure afforded a bright yellow solid. ESI-MS: found m/z = 338.3 (M + H*); calc. 337 amu 10 'H NMR (DMSO-d 6 ) 8 = 1.58-1.64 (m, 4H), 3.30-3.34 (m, 2H), 3.48-3.53 (m, 2H), 4.48 (t, 1H), 7.57-7.63 (m, 3H), 7.66 (d, 1H), 8.35-8.38 (m, 2H), 9.30 (s, 1H), 9.46 (s, 1H), 10.13 (s, 1H) ppm. Preparation of 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl ethylcarbamate 15 30 mg (0.08 mmol) of 1-(4-hydroxybutyl)-3-(3-phenylpyrido[ 2 ,3-b]pyrazin-6-yl)urea were dissolved in 5 ml of pyridine, admixed with 7.6 pl (0.10 mmol) of ethyl isocyanate and stirred at 1000C for 6 h. The reaction mixture was poured onto 200 ml of water and stirred for 15 min. The precipitated solid was filtered off and dried. This gave a white solid. 20 ESI-MS: found m/z = 409.4 (M + H*); calc. 408 amu 'H NMR (DMSO-d 6 ) 8 = 0.97 (t, 3H), 1.60-1.77 (m, 4H), 2.96-3.00 (m, 2H), 3.33-3.35 (m, 2H), 4.01-4.04 (m, 2H), 7.07 (t, 1H), 7.58-7.64 (m, 3H), 7.66 (d, 1H), 8.35 (d, 2H), 8.38 (d, 1H), 9.32 (s, 1H), 9.47 (s, 1H), 10.17 (s, 1H) ppm. 25 Example 34: Methyl 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl carbonate (compound 39) Preparation of methyl 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyI carbonate 30 mg (0.08 mmol) of 1-(4-hydroxybutyl)-3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea 30 were suspended in 2 ml of dichloromethane and admixed with 9.3 pl (0.12 mmol) of W02007/054556 -273- PCT/EP2006/068322 methyl chloroformate, 23 pl (0.16 mmol) of triethylamine and 1 mg (0.01 mmol) of dimethylaminopyridine. The solution was stirred at room temperature for 4 h. The reaction mixture was diluted with 50 ml of dichloromethane, washed with water and dried (Na 2

SO

4 ). The solvent was removed under reduced pressure and the residue 5 was purified by column chromatography on silica gel (dichloromethane/methanol eluent). A white solid was isolated. ESI-MS: found m/z = 396.3 (M + H*); calc. 395 amu 'H NMR (DMSO-d 6 ) S = 1.61-1.66 (m, 2H), 1.76-1.78 (m, 2H), 3.34-3.36 (m, 2H), 3.67 (s, 1H), 4.17-4.19 (m, 2H), 7.59-7.63 (m, 3H), 7.66 (d, 1H), 8.35 (d, 2H), 8.38 (d, 1H), 10 9.34 (s, 1H), 9.47 (s, 1H), 10.17 (s, 1H) ppm. The following example was synthesized according to Example 34 and the general synthesis methods: 15 Example 35: 2,2-Dimethyl[1,3]dioxolan-4-ylmethyl 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl carbonate (compound 40) ESI-MS: found m/z = 496.0 (M + H*); calc. 495 amu 20 'H NMR (DMSO-d 6 ) S = 1.24 (s, 3H), 1.29 (s, 3H), 1.61-1.67 (m, 2H), 1.77-1.82 (m, 2H), 3.34-3.37 (m, 2H), 3.65 (dd, 1H), 3.98 (dd, 1H), 4.03 (dd, 1H), 4.15 (dd, 1H), 4.17 4.28 (m, 3H), 7.58-7.63 (m, 3H), 7.67 (d, 1H), 8.36 (d, 2H), 8.38 (d, 1H), 9.34 (s, 1H), 9.47 (s, 1H), 10.17 (s, 1H) ppm. 25 Example 36: 2,3-Dihydroxypropyl 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl carbonate (compound 41) Preparation of 2,3-dihydroxypropyl4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyI 30 carbonate W02007/054556 -274- PCT/EP2006/068322 50 mg (0.10 mmol) of 2,2-dimethyl[1,3]dioxolan-4-ylmethyl 4-[3-(3-phenylpyrido[2,3 b]pyrazin-6-yl)urealbutyl carbonate were dissolved in 20 ml of dichloromethane, admixed with 17 pl (0.13 mmol) of boron trifluoride ethyl etherate and stirred at room temperature for 4 h. The solvent was removed under reduced pressure and the residue 5 was purified by column chromatography on silica gel (dichloromethane/methanol eluent). A white solid was isolated. ESI-MS: found m/z = 456.4 (M + H*); calc. 455 amu 'H NMR (DMSO-d 6 ) 8 = 1.62-1.67 (m, 2H), 1.76-1.82 (m, 2H), 3.28-3.52 (m, 4H), 3.62 3.66 (m, 1H), 3.96 (dd, 1H), 4.11 (dd, 1H), 4.16-4.20 (m, 2H), 4.66 (t, 1H), 4.96 (d, 1H), 10 7.58-7.65 (m, 3H), 7.67 (d, 1H), 8.35 (d, 2H), 8.38 (d, 1H), 9.31 (s, 1H), 9.47 (s, 1H), 10.17 (s, 1H) ppm. Example 37: {4-[3-(3-Phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyllphosphonic acid (compound 43) 15 Preparation of {4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl1phosphonic acid 60 mg (0.13 mmol) of diethyl {4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl} phosphonate were dissolved in 5 ml each of dichloromethane and hexamethyldisilazane, and admixed with 100 mg (0.66 mmol) of bromotrimethylsilane. 20 After stirring at room temperature for 6 h, the reaction mixture was concentrated under reduced pressure and the residue was stirred with water for 2 h. This gave a yellow solid. ESI-MS: found m/z = 402.3 (M + H*); calc. 401 amu 'H NMR (DMSO-d 6 ) S = 1.51-1.68 (m, 6H), 3.33-3.36 (m, 2H), 7.58-7.63 (m, 3H), 7.73 25 (d, 1H), 8.33-8.37 (m, 3H), 9.06 (s, 1H), 9.44 (s, 1H), 10.12 (s, 1H) ppm. The following example was synthesized according to Example 37 and the general synthesis methods: 30 Example 38: W02007/054556 -275- PCT/EP2006/068322 (4-{3-[3-(4-Hydroxy-3-methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urealbutyl)phosphonic acid (compound 45) ESI-MS: found m/z = 448.3 (M + H*); calc. 447 amu 5 'H NMR (DMSO-d 6 ) 8 = 1.48-1.67 (m, 6H), 3.24-3.28 (m, 2H), 3.92 (s, 3H), 6.98 (d, 1H), 7.70 (d, 1H), 7.85 (dd, 1H), 7.89 (d, 1H), 8.28 (d, 1H), 8.95 (s, 1H), 9.38 (s, 1H), 10.02 (s, 1H) ppm. Example 39: 10 {2-[3-(3-Phenylpyrido[2,3-b]pyrazin-6-yl)urea]ethyl)phosphonic acid (compound 63) ESI-MS: found m/z = 374.2 (M + H*); calc. 373 amu 1 H NMR (d 6 -DMSO): 5 = 1.86-1.93 (m, 2H), 3.45-3.52 (m, 2H), 7.57-7.63 (m, 3H), 7.76 (d, 1H), 8.35 (d, 2H), 8.37 (d, 1H), 8.96 (s, 1H), 9.45 (s, 1H), 10.17 (s, 1H) ppm. 15 Example 40: Ethyl N-(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxalamidate (compound 59) Preparation of ethyl N-(3-phenylpyrido[2,3-b]pyrazifn-6-yl)oxalamidate (reaction 20 according to scheme 5) 200 mg (0.90 mmol) of 3-phenylpyrido[2,3-b]pyrazin-6-ylamine were dissolved in 20 ml of pyridine and admixed with 0.11 ml (0.99 mmol) of ethyloxalyl chloride. After stirring at room temperature for 2 h, the solution was poured onto ice-water. The precipitated solid was filtered off and washed thoroughly with water. This gave a bright yellow solid. 25 ESI-MS: found m/z = 323.2 (M + H*); calc. 322 amu 1 H NMR (DMSO-d 6 ) 8 = 1.37 (t, 3H), 4.35-4.41 (m, 2H), 7.60-7.66 (m, 3H), 8.38 (d, 2H), 8.43 (bs, 1H), 8.61 (d, 1H), 9.63 (s, 1H), 11.67 (s, 1H) ppm. Example 41: W02007/054556 -276- PCT/EP2006/068322 N -Ethyl-N'-(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxaamide (compound 60) Preparation of N-Ethyl-N'-(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxalamide (reaction according to scheme 5) 5 23 mg (0.07 mmol) of ethyl N-(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxalamidate were dissolved in 5ml of dry THF and admixed with 0-15 ml (0.38 mmol) of a 2.0 M ethylamine solution in THF. After stirring at room temperature for 48 hours the reaction mixture was neutralized. The precipitated solid was filtered off and the filtrate was concentrated to dryness 10 under reduced pressure. The resulting solid was purified by column chromatography on silica gel (dichloromethane/methanol elutent). This gave a bright yellow solid. ESI-MS: found m/z = 322.3 (M + H*); calc. 321 amu 1 H NMR (DMSO-d 6 ) 8 = 1.13 (t, 3H), 3.27 (q, 2H), 7.60-7.66 (m, 3H), 8.39 (d, 2H), 8.54 (d, 1H), 8.65 (d, 1H), 9.24 (t, 1H), 9.64 (s, 1H), 10.31 (s, 1H) ppm. 15 Example 42: Ethyl 4-[6-(3-ethyl-1- phenylurea)pyrido[2,3-b]pyrazin-3-yl]phenylcarbamate (compound 20) 20 Preparation of ethyl 4-[6-(3-ethyl-1-phenylurea)pyrido[2,3-b]pyrazin-3 yl]phenylcarbamate (reaction according to scheme 5) 100 mg of 4-(6-phenylaminopyrido[2,3-b]pyrazin-3-yl)phenol hydrochloride (0.28 nmol) were initially charged in 3 ml of pyridine, and 65.3 mg of ethyl isocyanate (0.90 mmol) were added at room temperature. The mixture was left to stir at 800C for 5 h, then 25 another 32.0 mg of ethyl isocyanate (0.45 mmol) were added and the mixture was left to stir at 800C for a further 4 h. The solvent was then removed under reduced pressure. The resulting solid was purified twice by means of column chromatography on silica gel (dichloromethane/methanol and n-heptane/acetone eluent). This gave a bright yellow solid. 30 m.p.: 147-151 OC ESI-MS: found m/z = 457.3 (M + H*); calc. 456 amu W02007/054556 PCT/EP2006/068322 -277 1 H NMR (CDCl3): 8 = 1.28 (t, 3H), 1.40 (t, 3H), 3.39 (quint, 2H), 3.57 (quint, 2H), 5.09 (t, 1H), 6.80 (d, 1H), 7.37 (d, 2H), 7.40 (d, 2H), 7.50 (t, 1H), 7.57 (t, 2H), 8.10 (d, 1H), 8.30 (d, 2H), 9.25 (s, 1H), 10.76 (t, 1H) ppm. 5 For the preparation of 4-(6-phenylaminopyrido[2,3-b]pyrazin-3-yl)phenol hydrochloride, reference is made here to WO 99/17759. Example 43: tert-Butyl { 4 -[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl}carbamate (compound 21) 10 Preparation of tert-butyl {4-[6-(3-ethylurea)pyrido[2,3-b]jpyrazin-3-yl]phenyl}carbamate (reaction according to scheme 6) 83 mg of 1-(3-chloropyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (0.33 mmol), 120 mg of tert butyl [4-(4,4,5,5-tetramethyl[ 1,3,2]dioxaborolan-2-yl)phenyl]carbamate (0.36 mmol), 15 106 mg of sodium carbonate (1.00 mmol) and 19 mg of tetrakis-(triphenylphosphine) palladium (0.02 mmol) were initially charged in 7 ml of degassed dimethylformamide/water mixture. The mixture was heated to 100*C for 4 h. The cooled mixture was admixed with water. The precipitated solid was filtered off and washed with water and dichloromethane. This gave a beige solid. 20 m.p.: 281-283 *C ESI-MS: found m/z = 409.4 (M + H); calc. 408 amu 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 1.52 (s, 9H), 3.25 - 3.38 (m, 2H), 7.65 (d, 1 H), 7.69 (d, 2H), 8.29 (d, 2H), 8.33 (d, 1H), 9.09 (bs, 1H), 9.41 (s, 1H), 9.72 (s, 1H), 10.09 (s, 1H) ppm. 25 The following examples were synthesized according to Example 43 and the general synthesis methods: Example 44: W02007/054556 PCT/EP2006/0683 22 - 278 2-Methoxyethyl

{

4

-[

6

-(

3 -ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenylIcarbamate (compound 22) m.p.: 249-251 0C 5 ESI-MS: found m/z = 411.3 (M + H*); calc. 410 amu 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.31 (s, 3H), 3.45 - 3.38 (m, 2H), 3.58 - 3.64 (m, 2H), 4.24 - 4.27 (m, 2H), 7.65 (d, 1 H), 7.70 (d, 2H), 8.31 (d, 2H), 8.37 (d, 1 H), 9.08 (bs, 1H), 9.41 (s, 1H), 10.09 (s, 1H), 10.11 (s, 1H) ppm. 10 Example 45: 1-Ethyl-3-{3-[4-(3-ethylurea)phenyl pyrido[2,3-b]pyrazin-6-yllurea (compound 23) m.p.: > 350 *C (decomp.) ESI-MS: found mlz = 380.2 (M + H*); calc. 379 amu 15 'H NMR (d-DMSO): 8 = 1.08 (t, 3H), 1.20 (t, 3H), 3.14 (quint, 2H), 3.32 - 3.38 (m, 2H), 6.33 (t, 1H), 7.60-7.64 (m, 3H), 8.25 (d, 2H), 8.32 (d, 1H), 8.88 (s, 1H), 9.12 (bs, 1H), 9.39 (s, 1H), 10.06 (s, 1H) ppm. Example 46: 20 1 -{ 3

-[

4

-(

3

,

3 -Dimethylurea)phenyl]pyrido[2,3-b]pyrazin-6-yl}-3-ethylurea (compound 24) m.p.: > 350 *C ESI-MS: found m/z = 380.3 (M + H*); calc. 379 amu 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 2.98 (s, 6H), 3.25 - 3.38 (m, 2H), 7.63 (d, 1 H), 25 7.74 (d, 2H), 8.26 (d, 2H), 8.33 (d, 1H), 8.63 (s, 1H), 9.12 (bs, 1H), 9.41 (s, 1H), 10.07 (s, 1H) ppm. Example 47: W02007/054556 PCT/EP2006/068322 - 279 1-Ethyl-3-{3-[6-(3-ethylurea)pyridin-3-yl]pyrido[2,3-b]pyrazin-6-yl urea (compound 25) ESI-MS: found m/z = 381.2 (M + H*); calc. 380 amu 'H NMR (d 6 -DMSO): 8 = 1.13 (t, 3H), 1.20 (t, 3H), 3.23 (quint, 2H), 3.25 - 3.38 (m, 2H), 5 7.63 (d, 1H), 7.67 (d, 1H), 8.25 (d, 1H), 8.00 (bs, 1H), 8.35 (d, 1H), 8.61 (d, 1H), 9.08 (bs, 1H), 9.17 (s, 1H), 9.44 (s, 1H), 9.55 (s, 1H), 10.12 (s, 1H) ppm. Example 48: 1 -Ethyl-3-[3-(4-morpholin-4-ylmethylphenyl)pyrido[2,3-b]pyrazin-6-ylurea 10 (compound 28) ESI-MS: found m/z = 393.4 (M + H*); calc. 392 amu 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 2.41 (bs, 4H), 3.33 - 3.38 (m, 2H), 3.58 (s, 2H), 3.61 (t, 4H), 7.55 (d, 2H), 7.69 (t, 1H), 8.30 (d, 2H), 8.37 (d, 1H), 9.10 (bs, 1H), 9.44 (s, 15 1H), 10.13 (s, 1H) ppm. Example 49: N-{4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl}-2-(2-methoxyethoxy)acetamide (compound 30) 20 m.p.: 212-215 OC ESI-MS: found m/z = 425.2 (M + H*); calc. 424 amu 'H NMR (d 6 -DMSO): 6 = 1.20 (t, 3H), 3.32 (s, 3H), 3.34 - 3.38 (m, 2H), 3.56 (dd, 2H), 3.71 (dd, 2H), 4.15 (s, 2H), 7.66 (d, 1H), 7.89 (d, 2H), 8.33-8.36 (m, 3H), 9.11 (bs, 1H), 25 9.43 (s, 1H), 9.97 (s, 1H), 10.11 (s, 1H) ppm. Example 50: 2-Benzyloxy-N-{4-[6-(3-ethylurea)pyrido[ 2 ,3-b]pyrazin-3-yl]phenyllacetamide (compound 35) W02007/054556 PCT/EP2006/068322 - 280 m.p.: 254-256 *C ESI-MS: found m/z = 457.3 (M + H*); calc. 456 amu 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.28 - 3.38 (m, 2H), 4.16 (s, 2H), 4.66 (s, 2H), 5 7.31 (t, IH), 7.33 (t, 1H), 7.40 (t, 2H), 7.44 (d, 1H), 7.66 (d, 1H), 7.91 (d, 2H), 8.33-8.36 (m, 3H), 9.11 (bs, 1H), 9.44 (s, 1H), 10.10 (s, 1H), 10.14 (s, 1H) ppm. Example 51: 1-Ethyl-3-[3-(3-trimethylsilanylphenyl)pyrido[2,3-b]pyrazin-6-yl]urea (compound 46) 10 m.p.: 224-228 *C ESI-MS: found m/z = 366.4 (M + H*); calc. 365 amu 'H NMR (d 6 -DMSO): 8 = 0.35 (s, 9H), 1.21 (t, 3H), 3.28 - 3.38 (m, 2H), 7.60 (t, 1 H), 7.73 (t, 2H), 8.32 (d, 1H), 8.37 (d, 1H), 8.46 (s, 1H), 9.04 (bs, 1H), 9.48 (s, 1H), 10.12 15 (s, 1H) ppm. In Example 51, dioxane/water was used as the solvent instead of dimethylformamide/water. 20 Commercially unavailable boronic acid derivatives were prepared by the following method or processes known to those skilled in the art: Preparation of 2-methoxyethyl [4-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)phenyl] carbamate 25 107 mg of 4-(4,4,5,5-tetramethy[1,3,2]dioxaborolan-2-yl)phenyla mine (0.48 mmol) were dissolved in tetrahydrofuran. 96 mg of 2-methoxyethyl chloroformate (0.68 mmol) and 79 mg of N-methylmorpholine (0.78 mmol) were added at room temperature. The mixture was left to stir at room temperature for 1 day, precipitated solid was filtered off W02007/054556 PCT/EP2006/068322 - 281 and the solvent was removed under reduced pressure. This gave a yellowish oil which was used without further purification in the next reaction. The following boronic acid derivatives were prepared by the above method or 5 processes known to those skilled in the art: 1 -ethyl-3-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]urea 1, 1 -dimethyl-3-[4-(4,4,5,5-tetramethyl-[ 1, 3,2]dioxaborolan-2-yl)phenyl]urea 1 -ethyl-3-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl)urea 2-(2-methoxyethoxy)-N-[4-(4,4,5,5-tetramethyl-[ 1,3,2]dioxaborolan-2 10 yl)phenyl]acetamide 2-benzyloxy-N-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]acetamide Example 52: 1-Ethyl-3-{3-[2-(4-fluorophenyl)ethyl]pyrido[2,3-b]pyrazin-6-yl urea (compound 26) 15 Preparation of 1-ethyl-3-{3-[2-(4-fluorophenyl)ethyl]pyrido[ 2 ,3-b]pyrazin-6-yl}urea 108 mg of 1-ethyl-3-{3-[2-(4-fluorophenyl)vinyl]pyrido[2,3-b]pyrazin-6-yl}urea (0.32 mmol) (Example 27) were dissolved in hot ethanol. 112 mg of ammonium formate (1.78 mmol) and 110 mg of palladium (10%) on carbon were added, and the reaction 20 mixture was heated under reflux for 7.5 h. The catalyst was filtered off from the cooled reaction mixture, and the mother liquor was freed from the solvent. The crude product was purified by column chromatography on silica gel (dichloromethane/methanol eluent). This gave a yellow solid. m.p.: 207-209 *C 25 ESI-MS: found m/z = 340.2 (M + H*); calc. 339 amu 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.12 (t, 2H), 3.25 - 3.38 (m, 4H), 7.10 (t, 2H), 7.32 (dd, 2H), 7.63 (d, 1H), 8.31 (d, 1H), 8.71 (s, 1H), 9.09 (bs, 1H), 10.06 (s, 1H) ppm. Example 53: W02007/054556 -282- PCT/EP2006/068322 1 -Ethyl-3-(3-{4-[2-(2-methoxyethoxy)ethoxy]phenylpyrido[2,3-b]pyrazin-6-yl)urea (compound 29) Preparation of 1-ethyl-3-(3-{4-[2-(2-methoxyethoxy)ethoxy]phenyl pyrido[2,3-b]pyrazin 5 6-yl)urea (reaction according to scheme 9) 29 mg of sodium hydride (0.71 mmol) (60% suspension in mineral oil) were initially charged in 4 ml of dried dimethylformamide. At 0*C, 70 mg of 1-ethyl-3-[3-(4-hydroxy phenyl)pyrido[2,3-b]pyrazin-6-yl]urea (0.23 mmol) were added dissolved in 2.5 ml of dimethylformamide. The mixture was stirred at room temperature for 1 h. 10 Subsequently, 68 mg of 1-bromo-2-(2-ethoxymethoxy)ethane (0.34 mmol) were added at 0*C and the reaction mixture was stirred at room temperature for 17 h. Thereafter, another 22 mg of 1-bromo-2-(2-ethoxymethoxy)ethane (0.12 mmol) were added and the reaction mixture was stirred at 80'C for 2 h. Water was added to the cooled reaction mixture and the aqueous phase was extracted with dichloromethane. After the 15 organic phase had been dried over sodium sulphate, the solvent was removed and the crude product was purified by column chromatography on silica gel (dichloromethane/methanol) eluent. This gave a yellow solid. ESI-MS: found m/z = 412.3 (M + H*); calc. 411 amu 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.26 (s, 3H), 3.29 - 3.38 (m, 2H), 3.48 (dd, 2H), 20 3.62 (dd, 2H), 3.80 (dd, 2H), 4.22 (dd, 2H), 7.17 (d, 2H), 7.64 (t, 1H), 8.31-8.35 (m, 3H), 9.14 (bs, 1H), 9.42 (s, 1H), 10.09 (s, 1H) ppm. Example 54: N-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]-4-methylbenzamide (compound 31) 25 Preparation of N-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]-4-methylbenzamide (reaction according to scheme 7) 100 mg of 1-(3-aminopyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (0.43 mmol) were initially charged in 5 ml of dried pyridine, and 57 pl of p-tolyl chloride (0.43 mmol) were added 30 dropwise. The mixture was stirred at 600C for 2 h. Thererafter, another 29 pl of p-tolyl chloride (0.22 mmol) were added dropwise and the reaction mixture was stirred at 600C WO2007/054556 -PCT/EP2006/068322 W0207/05556-283 for a further 2 h. The cooled reaction mixture was added to ice-water and neutralized with 1 N HCI, and the solid was filtered off with suction. The crude product was purified by column chromatography on silica gel (dichloromethane/methanol eluent). This gave a yellowish solid. 5 ESI-MS: found m/z = 351.1 (M + H*); calc. 350 amu 'H NMR (d 6 -DMSO): 8 = 1.18 (t, 3H), 2.42 (s, 3H), 3.31 (quint, 2H), 7.37 (d, 2H), 7.55 (d, 1H), 8.04 (d, 2H), 8.31 (d, 1H), 9.10 (bs, 1H), 9.56 (s, 1H), 9.96 (s, 1H), 11.39 (bs, 1H) ppm. 10 Example 55: 1-[3-(4-Cyclohexylphenylamino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea (compound 47) Preparation of 1-[3-(4-cyclohexylphenylamino)pyrido[2,3-b]pyrazin-6-yl]-3-ethylurea (reaction according to scheme 3) 15 83 mg of 1-(3-chloropyrido[2,3-b]pyrazin-6-yl)-3-ethylurea (0.33 mmol), 99 mg of 4-cyclohexylaniline (0.55 mmol), 30 mg of sodium tert-butoxide (0.30 mmol), 29 mg of tris(dibenzylideneacetone)dipalladium(O) (0.03 mmol) and 68 mg of 2-(dicyclohexylphosphanyl)biphenyl (0.19 mmol) were initially charged in 1.5 ml of dried toluene. The reaction mixture was heated to 100 0 C under nitrogen in a 20 microwave (100 watt) for 30 minutes. The solvent was removed under reduced pressure and the crude product was purified by column chromatography on silica gel (dichloromethane/methanol eluent). This gave a yellow solid. m.p.: 246-248 *C ESI-MS: found m/z = 391.3 (M + H*); calc. 390 amu 25 1 H NMR (d 6 -DMSO): 8 = 1.18 (t, 3H), 1.22-1.26 (m, 1H), 1.33-1.44 (m, 4H), 1.71 (d, 1 H), 1.80 (d, 4H), 2.45-2.51 (m, 1 H), 3.25 - 3.30 (m, 2H), 7.22 (d, 2H), 7.40 (d, 1 H), 7.89 (d, 2H), 8.08 (d, 1H), 8.37 (s, 1H), 8.73 (bs, 1H), 9.87 (s, 1H), 10.06 (s, 1H) ppm. The following examples were synthesized according to Example 55 and the general 30 synthesis methods: W02007/054556 PCT/EP2006/068322 - 284 Example 56: 1 -Ethyl-3-[3-(4-methanesulphonylphenylamino)pyrido[2,3-blpyrazin-6-yl]urea (compound 48) 5 m.p.: 275-280 0C ESI-MS: found m/z = 387.3 (M + H*); calc. 386 amu 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.19 (s, 3H), 3.25 - 3.38 (m, 2H), 7.54 (d, 1H), 7.92 (d, 2H), 8.16 (d, 1H), 8.24 (d, 2H), 8.49 (s, 1H), 8.62 (bs, 1H), 9.93 (s, 1H), 10.56 10 (s, 1H) ppm. Example 57: N-{5-[6-(3-Ethylurea)pyrido[2,3- b]pyrazin-3-ylamino]-2-m ethylphenyl} methanesulphonamide (compound 49) 15 m.p.: 247-250 0C ESI-MS: found m/z = 416.2 (M + H*); calc. 415 amu 'H NMR (d 6 -DMSO): S = 1.17(t, 3H), 2.28 (s, 3H), 3.03 (s, 3H), 3.25 - 3.38 (m, 2H), 7.23 (d, 1H), 7.33 (d, 1H), 7.75 (d, 1H), 8.06-8.09 (m, 2H), 8.37 (s, 1H), 8.92 (bs, 1H), 20 9.09 (s, 1H), 9.77 (s, 1H), 10.09 (s, 1H) ppm. Example 58: 3-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]-N-methylbenzamide (compound 50) 25 m.p.: 228-234 *C ESI-MS: found m/z = 366.4 (M + H*); calc. 365 amu W02007/054556 PCT/EP2006/068322 - 285 'H NMR (d 6 -DMSO): 8 = 1.19 (t, 3H), 2.80 (d, 3H), 3.25 - 3.38 (m, 2H), 7.39-7.48 (m, 3H), 8.09 - 8.11 (m, 2H), 8.41 (s, 2H), 8.46 (s, 1H), 8.83 (bs, 1H), 9.86 (s, 1H), 10.22 (s, 1H) ppm. 5 Example 59: 1 -Ethyl-3-[3-(4-piperidin-1 -ylmethylphenylamino)pyrido[ 2 ,3-b]pyrazin-6-yl]urea (compound 51) m.p.: 221-224 *C 10 ESI-MS: found m/z = 406.4 (M + H*); calc. 405 amu 1 H NMR (d 6 -DMSO): 8 = 1.19 (t, 3H), 1.39 (bs, 2H), 1.49 (quint, 4H), 2.32 (bs, 4H), 3.25 - 3.35 (m, 2H), 3.39 (s, 2H), 7.27 (d, 2H), 7.39 (d, 1 H), 7.92 (d, 2H), 8.08 (d, 1 H), 8.38 (s, 1H), 8.78 (bs, 1H), 9.82 (s, 1H), 10.05 (s, 1H) ppm. 15 Example 60: 1-Ethyl-3-[3-(4-thiophen-3-ylphenylamino)pyrido[2,3-b]pyrazin-6-yl]urea (compound 52) m.p.: 264-267 *C ESI-MS: found m/z = 391.4 (M + H*); calc. 390 amu 20 1 H NMR (d 6 -DMSO): S = 1.21 (t, 3H), 3.25 - 3.35 (m, 2H), 7.47 (d, 1H), 7.58 (d, 1H), 7.65 (dd, 1H), 7.74 (d, 2H), 7.82 (d, 1H), 8.05 (d, 2H), 8.11 (d, 1H), 8.42 (s, 1H), 8.62 (bs, 1H), 9.86 (s, 1H), 10.18 (s, 1H) ppm. Example 61: 25 N-{4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]phenylacetamide (compound 53) ESI-MS: found m/z = 366.2 (M + H*); calc. 365 amu W02007/054556 PCT/EP2006/068322 - 286 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 2.03 (s, 3H), 3.25 - 3.35 (m, 2H), 7.27 (d, 1H), 7.34 (d, 2H), 7.57 (d, 2H), 7.90 (d, IH), 8.07 (d, 1H), 8.94 (bs, 1H), 9.79 (s, 1H), 9.89 (s, 1H), 10.03 (s, IH) ppm. 5 Example 62: Ethyl 3-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]benzoate (compound 54) m.p.: 252-255 OC ESI-MS: found m/z = 381.3 (M + H'); calc. 380 amu 10 H NMR (d 6 -DMSO): S = 1.19 (t, 3H), 1.35 (t, 3H), 3.25 - 3.35 (m, 2H), 4.35 (q, 2H), 7.40 (d, 1H), 7.52 (t, 1H), 7.64 (d, 1H), 8.12 (d, 1H), 8.29 (d, 1H), 8.41 (s, 1H), 8.62 (s, 1H), 8.90 (bs, 1H), 9.86 (s, 1H), 10.31 (s, 1H) ppm. Example 63: 15 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl 2-methoxyethyl carbonate hydrochloride (compound 55) Preparation of 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl 2-methoxyethyl carbonate hydrochloride 20 21 mg of 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl 2-methoxyethyl carbonate (0.05 mmol) (Example 10) were dissolved in 2.5 ml of dichloromethane/methanol (2:1). 0.02 ml of 5-6N HCI solution in 2-propanol was added and the mixture was stirred at room temperature for 1 day. The solvent was then removed. This gave a yellow solid. m.p.: 190-193 *C 25 1 H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 3.31 - 3.35 (m, 5H), 3.63-3.66 (m, 2H), 4.37 (dd, 2H), 7.50 (d, 2H), 7.70 (d, 1H), 8.38 (d, 1H), 8.41 (d, 2H), 9.09 (bs, 1H), 9.47 (s, 1H), 10.14 (s, 1H) ppm. Example 64: W02007/054556 -287- PCT/EP2006/068322 4-[6-(3-Ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl 2-methoxyethyl carbonate p-toluenesulphonate (compound 56) Preparation of 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl 2-methoxyethyl 5 carbonate p-toluenesulphonate 48 mg of 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yllphenyl 2-methoxyethyl carbonate (0.12 mmol) were initially charged in 4 ml of dichloromethane and 0.7 ml of methanol. 23 mg of p-toluenesulphonic acid monohydrate (0.12 mmol) were added at room temperature dissolved in 2 ml of dichloromethane and 0.5 ml of methanol. The reaction 10 mixture was stirred at 00C for 1 h and at room temperature for 1 day. The solvent was removed and the residue recrystallized from dichloromethane/n-heptane. The precipitated product was filtered off with suction and washed with n-heptane. This gave a yellow solid. m.p.: 145-147 0C 15 'H NMR (d 6 -DMSO): 8 = 1.20 (t, 3H), 2.29 (s, 3H), 3.30 - 3.36 (m, 5H), 3.64 (dd, 2H), 4.38 (dd, 2H), 7.11 (d, 2H), 7.47 (d, 2H), 7.50 (d, 2H), 7.70 (d, 1H), 8.38 (d, 1H), 8.41 (d, 2H), 9.09 (bs, 1H), 9.47 (s, 1H), 10.14 (s, 1H) ppm. Example 65: 20 4-{6-[3-(4-Hydroxybutyl)urea]pyrido[2,3-b]pyrazin-3-ylphenyl 2-methoxyethyl carbonate hydrochloride (compound 58) Preparation of 4-{6-[3-(4-hydroxybutyl)urea]pyrido[2,3-b]pyrazin-3-ylphenyl 2-methoxyethyl carbonate hydrochloride 25 117 mg of 4-6-[3-(4-(tert-butyldimethylsiIanyloxy)butyl)urea]pyrido[2,3-b]pyrazin-3-yl} phenyl 2-methoxyethyl carbonate (0.21 mmol) were dissolved in 40 ml of predried dichloromethane. 0.5 ml of 5-6N HCI solution in 2-propanol was added and the reaction mixture was stirred at room temperature for 15 minutes. The organic phase was washed with water, dried over sodium sulphate and concentrated. This gave a yellow 30 solid. m.p.: 165-168 *C W02007/054556 PCT/EP2006/068322 - 288 ESI-MS: found m/z = 456.2 (M + H*); calc. 455 amu 'H NMR (d 6 -DMSO): 8 = 1.61 (quint, 4H), 2.29 (s, 3H), 3.30 - 3.36 (m, 2H), 3.49 (t, 2H), 3.64 (dd, 2H), 4.38 (dd, 2H), 7.49 (d, 2H), 7.66 (d, 1H), 8.38 (d, 1H), 8.43 (d, 2H), 9.33 (bs, 1H), 9.48 (s, 1H), 10.17 (s, 1H) ppm. 5 For the preparation of 4-{6-[3-(4-(tert-butyldimethylsilanyloxy)butyl)urea]pyrido[2,3 b]pyrazin-3-yl}phenyl 2-methoxyethyl carbonate, reference is made here to schemes 5, 6 and 8, the general synthesis methods and the processes known to those skilled in the art. 10 Example 66: 2,2-Dimethylpropionyloxymethoxy-(4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3 b]pyrazin-6-yl]urea}butyl)phosphinoyloxymethyl 2,2-dimethylpropionate (compound 65) 15 Preparation of 2,2-dimethylpropionyloxymethoxy-(4-{3-[3-(4-hydroxy-3-methoxy phenyl)pyrido[2,3-b]pyrazin-6-yl]urealbutyl)phosphinoyloxymethyl 2,2-dimethyl propionate 94 mg of 4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea}butyl) 20 phosphonic acid (0.20 mmol) were dissolved in 15 ml of DMF, admixed with 360 p of chloromethyl pivalate (2.40 mmol) and 30 pl of triethylamine (0.21 mmol) and stirred at 60'C for 10 h. The reaction mixture was poured onto 50 ml of water and extracted three times with ethyl acetate. The combined organic phases were dried over MgSO 4 and the solvent was removed under reduced pressure. The residue was subsequently 25 purified by column chromatography (eluent: dichloromethane/methanol). A beige solid was isolated. ESI-MS: found m/z = 676.4 (M + H*); calc. 675 amu W02007/054556 -289- PCTIEP2006/068322 'H NMR (d 6 -DMSO): S = 1.12 (s, 18H), 1.57-1.68 (m, 4H), 1.90-1.97 (m, 2H), 3.28-3.31 (m, 3.93 (s, 3H), 5.54-5.59 (m, 4H), 6.97 (d, 1H), 7.64 (d, 1H), 7.86 (dd, 1H), 7.91 (d, 1H), 8.32 (d, 1H), 9.08 (s, 1H), 9.41 (s, 1H), 9.70 (s, 1H), 10.06 (s, 1H) ppm.

W02007/054556 -290- PCT/EP2006/068322 II) Biological effects of the inventive compounds 11.1) Cell-free kinase assays (by means of ALPHA technology) 5 The inhibitory effect of the inventive compounds was tested on various human serine/threonine kinases, tyrosine kinases and lipid kinases in enzymatic assays. Recombinant human kinases, for example Erk2, Pl3Kalpha, -beta, -gamma, -delta, p38alpha, p38gamma, Jnkl, Jnk2 and others were used, in some cases as full-length kinases, in some cases as truncated fragments - but at least consisting of the 10 functional kinase domains. The commercial kinase proteins (Proqinase, Upstate) were used as recombinant fusion proteins with GST (glutathione S-transferase) tag or His tag. Depending on the substrate type, the different kinase reactions were quantified by means of suitable ALPHA T M beads (PerkinElmer). 15 Testinq The substrate testing on the Erk assay is described in detail below. Selected test results of the Erk2, P13Kalpha assays are cited below. To determine the IC 50 value, the potential inhibitor substances were investigated at 10 half-logarithmically graduated concentrations of 3.16 nM-1OOpM. 20 a) Erk2-ALPHA: The test substance, 0.625 ng of Erk2 (#14-173, Upstate), 10pM ATP and 15 nM biotinylated MBP (myelin basic protein) substrate were incubated on a 384-well Optiplate (Perkin Elmer) in a volume of 15 pl for 1h in 25 mM Tris, 10 mM MgCl 2 , 0.1% Tween-20, 100 pM NaVO 4 , 2 mM DTT at pH 7.5. The kinase reaction 25 was then stopped by adding 10 pl of the ALPHA bead mix (10 pg/ml, #6760617/ PerkinElmer), pre-incubated with anti-phospho MBP antibody (320 pM, #05-429/ Upstate), in 25 mM Tris, 200 mM NaCI, 100 mM EDTA and 0.3% BSA, and left to stand overnight. b) PI3K-ALPHAs (e.g. P13Kalpha): The test substance, 1 ng of Pl3Kalpha (#14-602, 30 Upstate), 100 pM ATP and 20 pM PIP 2 substrate (#P4508, Echelon) on a 384-well Optiplate (Perkin Elmer) for 1 h in 50 mM Hepes, 50 mM NaCl, 5 mM MgCl 2 , 0.05% Chaps, 5 mM DTT at pH 7.4. Subsequently, the kinase reaction was stopped by W02007/054556 -291- PCT/EP2006/06832 2 adding the ALPHA bead mix (10 pg/ml, #6760603/ PerkinElmer), preincubated with 1 nM GST:Grpl fusion protein (Upstate) and 15 nM biotinylated PIP3 (#C-39B6/ Echelon) in 50 mM Hepes, 50 mM NaCl, 50 mM EDTA and 0.1% BSA, and left to stand overnight. 5 The fluorescence was detected the next morning in a Fusion T M alpha instrument (Perkin Elmer). Evaluation 10 The calculation of % inhibition values per substance concentration was done by means of the following formula from the raw data determined in the Fusion TMalpha: %kinase inibition (- =100- 1 0 0 r mean, ea%,*.,) 15 The controls were each determined 8 times, the substance samples each twice. 0% control contained neither any ATP nor any substrate; the 100% control contained no test substance. The IC 50 values were determined with GraphPadPrism. The inventive compounds exhibited effective inhibition of Erk, P13K, p38alpha and Jnk1 + Jnk2 with ICso values up to 88nM (see Table 1).

W02007/054556 -292- PCTJEP2006/068322 Table 1: MAPK and Pl3Kalpha kinase assay test results (IC50 [pM] at 10pM or 100pM* ATP) Compound Erk2 P13Kalpha p38alpha Jnk1 + Jnk2 3 5.8 16.8 Not tested not tested 6 2.4 21.3 Not tested not tested 7 0.407 27.9 >100 11.4 8 4.1 27.2 >100 19.4 9 0.117 7.8 >100 >100 10 0.088 2.6 >100 2.9 11 0.27 >31.6 >100 >100 12 2.8 3.4 8.8 0.637 13 0.64 >31.6 >100 >100 16 0.513 3.3 >100 5.6 17 0.167 11.8 >100 >100 19 3.9 2.3 >100 10.1 21 >100 1.2 >100 >31.6 22 >100 1.2 >100 >31.6 23 1.9 1.3 >100 5.7 25 3.4 4.4 >100 24.2 28 0.364 1.8 >100 5 29 0.396 2.3 >100 24.2 30 >31.6 0.749 >100 13.8 32 0.824 1.3 >100 4.2 44 2.8 10.7 >100 8.4 45 0.243 12.5 >100 0.974 48 >100 1.1 >100 >31.6 49 9.6 1.9 4 >31.6 50 4.7 0.683 18.1 >31.6 51 19.1 7.5 >100 >31.6 53 16.5 0.677 >100 20.4 55 0.812 3.6 >100 2.9 56 0.272 1.3 >100 3.1 58 0.763 4.3 >31.6 2.5 61 0.3 1.5 >100 2.1 W02007/054556 PCT/EP2006/068322 - 293 11.2) Cellular assay: Testing for anti-proliferative action (XTT assay) The principle of this test is based on the intracellular reduction of the tetrazolium dye XTT (sodium 3'-[1-(phenylaminocarbonyl)-3,4-tetrazolium]bis(4-methoxy-6 5 nitro)benzenenesulphonic acid, Sigma) to a formazan dye by mitochondrial dehydrogenases. The dye is formed only by metabolically active cells; its photometrically measurable intensity is a quantitative indicator for the presence of living cells. The reduction in the dye formation as a result of incubation of the cells with substances serves as a parameter for the anti-proliferative action. 10 Testing The tumour cell lines (ATCC) were seeded in 96-well microtitre plates in a defined cell count (5000 cells/well for BxPC3 and Hct1 16; 10 000 cells/well for MDA MB468), and then incubated overnight in an incubator at 371C, 5% CO 2 and 95% air humidity. The 15 test substances were made up as stock solutions (10 mM) in DMSO. To determine the

EC

50 values, the potential inhibitor substances were added to the cells in quater logarithmically graded dilutions, so as to result in final concentrations of 0.28 pM 50 pM. The cell plates were then incubated for 45 h in an incubator at 37*C, 5% C02 and 95% air humidity. 20 For the detection reaction, the XTT substrate was admixed with PMS (N-methyldibenzopyrazine methylsulphate, Sigma) and added to the cells, so as to result in a final concentration of 325 pg of XTT/ml and 2.5 pg PMS/ml. The mixture was then incubated for 3 h at 370C, 95% air humidity. Subsequently the formazan salt formed by cellular dehydrogenases was quantified at an adsorption of 490 nm. 25 Evaluation The evaluation of the % inhibition values was done by means of the following formula from the values for the optical densities measured in each case at 490 nm: 30 % inhibition of cell proliferation = 100f'IOx mean (,,) -mean0(xlo) mean1/,.6 col) - mean (0%conrol) W02007/054556 -294- PCT/EP2006/068322 The controls were determined 8 times each, the substance samples twice each. 0% control contained no cells; the 100% control contained no test substance. The EC 50 values were determined with GraphPadPrism. 5 The inventive compounds exhibited effective inhibition of cell proliferation in some cases with EC 50 values up to 2.2 pM (see Table 2). Table 2: XTT assay test results (EC50 [pM]) Compound BxPC3 MDA-MB468 Hct116 9 20 15 10 10 9 7 5 16 >25 11 11 17 >25 >25 3.4 23 >50 >25 16 32 5.9 4.5 2.2 49 not tested 16 approx. 20 56 >20 15.5 9.4 61 not tested 7.1 6 W020071054556 PCT/EP2006/068322 11.3) Cellular assay: Testing on substrate inhibition (Western blotting) This method enables a statement of whether the kinase modulator investigated achieves the desired effect in a cellular context too, i.e., in this case, a substrate 5 protein downstream of the target kinase is examined for its phosphorylation status. To this end, the cells incubated with substance are lysed and the overall protein is separated on a reducing polyacrylamide gel. Subsequently, the proteins are transferred by means of Western blotting to a PVDF membrane and the substrate bands sought are made visible with specific antibodies and a suitable detection method. The 10 substrate proteins downstream of the target kinases are detected simultaneously with an anti-phospho antibody which is specific in each case and simultaneously a total antibody which recognizes the substrate total protein. The duplex technology of the ODYSSEY imager (LiCOR) enables this simultaneous measurement. The intensity of the total substrate bands is employed to normalize and quantify the phosphorylation 15 inhibition or activation. Testing Suitable tumour cell lines (e.g. BxPC3, Hctl 16 or MDA MB468) were seeded into 6-well microtitre plates in a defined cell count (e.g. 350 000 cells/well for BxPC3 and 20 Hctl 16) in the particular standard complete media and then incubated overnight in an incubator at 370C, 5% C02 and 95% air humidity. The cells were then incubated further for a further 24 h under reduced-serum conditions, i.e. in the particular medium except at only 0.25% serum. The test substances were made up as stock solutions (10 mM) in DMSO and incubated with the cells at final concentrations of 5, 15.8 and 50 pM for 5 h. 25 This was followed by cell lysis in 25 mM Tris, 150 mM NaCl, 10 mM sodium pyrophosphate, 2 mM EGTA, 25 mM beta-glycerophosphate, 25 mM NaF, 10% glycerol, 0.75% NP-40, 100 pM NaVO 4 buffer. After protein quantification by means of BCA (bicinchonic acid protein assay kit, Sigma) assay, amounts of protein of about 20 pg per track were separated on a Lammli polyacrylamide gel and then transferred 30 onto a PVDF membrane (Millipore) by means of semi-dry Western blotting at 0.8 mA/cm 2 for 1 h. This was followed by prehybridization of the membrane for1 hour in I-block reagent (Applied Biosystems) and overnight incubation with the specific antibodies. To determine the Erk and P13K inhibition, the next substrates Rskl W02007/054556 PCT/EP2006/068322 - 296 downstream were detected with the total antibody (Rsk #sc-231g C-21, Santa Cruz) and the phospho antibody (Phospho-p90RSK (S380) #9341, NEB Cell Signalling) and Akt with the total antibody (Aktl #sc-1618 C-20, Santa Cruz) and the phospho antibody (Phospho-Akt (Ser 473) #9271, NEB Cell Signaling). After the membrane had been 5 washed, the secondary antibodies were incubated with anti-rabbit IR Dye 800 (#611 732-127, Rockland) for the phospho antibody and anti-goat Alexa Fluor 680 (#A-21081, Molecular samples) for the total protein antibody. After incubation for 30 min at room temperature in the dark, the hybridization of the detection antibody was detected on the membrane by scanning in an ODYSSEY imager (LiCOR). 10 Evaluation At concentrations of 5-50 pM, the inventive compounds exhibited dual inhibition of Erk (MAPK1/2) and of P13K (Table 3), which is indicated by inhibition of the band intensity of the two corresponding phospho-substrate proteins Rsk1 and Akt. 15 Table 3 Inhibition of cellular substrate phosphorylation (at 50 pM) Compound Erk -- +pRsk P13K -- pAkt 9 90% 50% 10 100% 100% 23 0% 70% 32 100% 90% 49 0% 90% W02007/054556 PCT/EP2006/068322 - 297 Abbreviations Akt from: murine Akt8 retrovirus or protein kinase B (PKB) Ask1 apoptosis signal-regulating kinase 5 ATR ataxia-telangiectasia and Rad3-related ATM ataxia-telangiectasia mutated Bag 1 Bcl-2 associated athanogene-1 Bcl-2 B-cell leukaemia/lymhoma-2 gene DNA-PK DNA-dependent protein kinase 10 Erk extracellular signal-regulated kinase Flt-3 fms like tyrosine kinase 3 GSK-3 glycogen synthase kinase-3 hSMG-1 human orthologue of product of seven nematode gene-1 JAK-3 Janus kinase 3 15 JNK c-jun N-terminal kinase MAPK mitogen activated protein kinase Mek MAP or Erk kinase mTOR mammalian target of rapamycin PDGFR platelet derived growth factor receptor 20 P13K phosphoinositol 3-kinase PIKK phosphoinositol 3-kinase related kinase

PIP

2 phosphatidylinositol biphosphate

PIP

3 phosphatidylinositol triphosphate Ptdlns phosphatidylinositol 25 Raf rapid accelerated fibrosarcoma Ras rat sarcoma RTK receptor tyrosine kinase SAPK stress-activated protein kinase Ser serine 30 Syk spleen tyrosine kinase Thr threonine Tyr tyrosine VEGFR vascular endothelial growth factor receptor

Claims

1. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) z 5 Z2 N -, 'Z4 5 Zi N N Z3 in which: (A) one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted aryl", where "substituted aryl" is substituted by at least one 10 substituent selected identically or differently from the group consisting of: (a) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-X1, -N(alkyl) 2 , NHC(O)-alkyl, -NHC(O)-cycloalkyl, -NHC(O)-heterocyclyl, -NHC(O) aryl, -NHC(O)-heteroaryl, -NHC(O)-arylalkyl, -NHC(O)-heteroarylalkyl, -NHS(0 2 )-alkyl, -NHS(0 2 )-cycloalkyl, -NHS(0 2 )-heterocyclyl, 15 NHS(0 2 )-aryl, -NHS(0 2 )-heteroaryl, -NHS(0 2 )-arylalkyl, -NHS(0 2 ) heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -O-X2, -OC(O)-alkyl, OC(O)-cycloalkyl, -OC(O)-heterocyclyl, -OC(O)-aryl, -OC(O) heteroaryl, -OC(O)-arylalkyl, -OC(O)-heteroarylalkyl, -OS(0 2 )-alkyl, OS(0 2 )-cycloalkyl, -OS(0 2 )-heterocyclyl, -OS(0 2 )-aryl, -OS(02) 20 heteroaryl, -OS(0 2 )-arylalkyl, -OS(02)-heteroarylalkyl, -C(O)-alkyl, C(O)-aryl, -C(O)-heteroaryl, -C(O)O-X3, -C(O)NH-X4, -C(O)N(alkyl) 2 , -C(O)N(cycloalkyl) 2 , -C(O)N(aryl)2, -C(O)N(heteroaryl)2, -S(O)-alkyl, S(O)-aryl, -S(0 2 )-alkyl, -S(0 2 )-aryl, -S(0 2 )NH-alkyl, -S(0 2 )NH-aryl, S(0 2 )NH-heteroaryl, -S(0 2 )NH-arylalkyl, S(0 2 )O-alkyl, -S(0 2 )O-aryl, 25 S(0 2 )O-arylalkyl"; where X1, X2, X3, X4 are each independently selected from the group consisting of: "alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; W02007/054556 PCT/EP2006/068322 with the proviso that the above substituents of substituent group (a) are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: (i) "(C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N 3 , -NH cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NX5X6, S-cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -0 10 cycloalkyl, -0-cycloalkylalkyl, -0-arylalkyl, -0-heteroaryl, -0 heteroarylalkyl, -0-heterocyclyl, -0-heterocyclylalkyl,-O(-X 7 -O)p X8 (p = 1, 2, 3, 4, 5), -OP(O)(OX9)(OX1 0), -C(O)O-X11, -C(O)NH 2 , -C(O)NH-X12, -C(O)NX13X14, -S(0 2 )-X15, -P(O)(OH) 2 , P(O)(OX1 6)(OX1 7), -Si(X1 8)(X1 9)(X20), -0-Si(X21)(X22)(X23), -0 15 C(O)-O-X24, -0-C(O)-NH-X25, -O-C(O)-NX26X27, -NH-C(O) 0-X28, -NH-C(O)-NH-X29, -NH-C(O)-NX3OX31, -NX32-C(O)-0 X33, -NX34-C(O)-NH-X35, -NX36-C(O)-NX37X38, -O-S(0 2 )-X39, -NH-C(O)-X40, -NX41-C(O)-X42, -C(O)-X43, -OC(O)-X44, S(O)-X45, -S(0 2 )-NHX46, -S(0 2 )-NX47X48, -S(0 2 )-OX49, -0( 20 X50-0)p-H (p = 1, 2, 3, 4, 5)"; with the further proviso that "-N(alkyl) 2 " is further substituted by at least one substituent selected from the following substituent group (b); where X5, X6, X7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, X18, X19, X20, X21, X22, X23, X24, X25, X26, X27, X28, X29, X30, 25 X31, X32, X33, X34, X35, X36, X37, X38, X39, X40, X41, X42, X43, X44, X45, X46, X47, X48, X49, X50 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X13, X14 and/or 30 X26, X27 and/or X30, X31 and/or X37, X38 and/or X47, X48 together may also form "heterocyclyl"; W02007/054556 PCT/EP2006/06832 2 - 300 and with the further proviso that when one of the Z3 or Z4 radicals is "substituted aryl" substituted by "heterocyclylalkyl", the other Z3 or Z4 radical in each case is not "substituted or unsubstituted aryl"; where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, 5 Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (b) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHX51, -NX52X53, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, 10 OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X54, -C(O)O-X55, -C(O)NH-X56, -C(O)NX57X58, -O-X59, -O(-X60-O)r-H (r = 1, 2, 3, 4, 5), -O(-X61-O)r-X62 (r = 1, 2, 3, 4, 5), -OC(O)-X63, -OC(0) O-X64, -OC(O)-NHX65, -0-C(O)-NX66X67, -OP(O)(OX68)(OX69), OSi(X70)(X71)(X72), -OS(0 2 )-X73, -NHC(O)-X74, -NX75C(O)-X76, 15 NH-C(O)-O-X77, -NH-C(O)-NH-X78, -NH-C(O)-NX79X80, -NX81 C(O)-O-X82, -NX83-C(O)-NH-X84, -NX85-C(O)-NX86X87, -NHS(0 2 ) X88, -NX89S(0 2 )-X90, -S-X91, -S(O)-X92, -S(0 2 )-X93, -S(0 2 )NH-X94, -S(0 2 )NX95X96, -S(0 2 )O-X97, -P(O)(OX98)(OX99), Si(X1 00)(X1 01)(X1 02)"; 20 where X51, X52, X53, X54, X55, X56, X57, X58, X59, X60, X61, X62, X63, X64, X65, X66, X67, X68, X69, X70, X71, X72, X73, X74, X75, X76, X77, X78, X79, X80, X81, X82, X83, X84, X85, X86, X87, X88, X89, X90, X91, X92, X93, X94, X95, X96, X97, X98, X99, X100, X101, X102 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, 25 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X57, X58 and/or X66, X67 and/or X79, X80 and/or X86, X87 and/or X95, X96 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (b) may each 30 independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, W020071054556 -301- PCT/EP2006/068322 CN, CF 3 , N 3 , NH 2 , -NHX103, -NX104X105, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X106, -C(O)O-X107, -C(O)NH-X108, C(O)NX1 09X1 10, -O-X1 11, -O(-X 12-O),-H (s = 1, 2, 3, 4, 5), -O( 5 X113-0) 5 -X114 (s = 1, 2, 3, 4, 5), -OC(O)-X115, -OC(O)-O-X116, OC(O)-NHX1 17, -O-C(O)-NX1 18X1 19, -OP(O)(OX1 20)(OX1 21), OSi(X122)(X123)(X124), -OS(O 2 )-X125, -NHC(O)-X126, NX127C(O)-X128, -NH-C(O)-O-X129, -NH-C(O)-NH-X130, -NH C(O)-NX131X132, -NX133-C(O)-O-X134, -NX135-C(O)-NH-X136, 10 -NX137-C(O)-NX138X139, -NHS(O 2 )-X140, -NX141S(0 2 )-X142, -S X143, -S(O)-X144, -S(O 2 )-X145, -S(0 2 )NH-X146, -S(0 2 )NX147X148, -S(O 2 )O-X1 49, -P(O)(OX1 50)(OX1 51), -Si(X1 52)(X1 53)(X1 54)"; where X103, X104, X105, X106, X107, X108, X109, X110, X111, X112, X113,X114,X115, Xll6,X117,X118,X119,X120,X121,X122,X 1 23 , 15 X124,X125,X126,X127,X128, X129,X130, X131, X132, X133,X134, X135, X136, X137, X138, X139, X140, X141, X142, X143, X144, X145, X146, X147, X148, X149, X150, X151, X152, X153, X154 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 20 heteroaryl, heteroarylalkyl" and where, alternatively, X109, X 110 and/or X118, X119 and/or X131, X132 and/or X138, X139 and/or X147, X148 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at 25 least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX155, -NX156X157, -NO 2 , -OH, -OCF 3 , -SH, 30 O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X158, -C(O)O-X159, -C(O)NH-X160, C(O)NX161X162, -O-X163, -O(-X164-0)-H (t = 1, 2, 3, 4, 5), -O( X165-O)t-X166 (t = 1, 2, 3, 4, 5), -OC(O)-X167, -OC(O)-O-X168, OC(O)-NHX169, -O-C(O)-NX170X171, -OP(O)(OX172)(OX173), - W02007/054556 PCT/EP2006/068322 - 302 OSi(X174)(X175)(X176), -OS(0 2 )-X177, -NHC(O)-X178, NX1 79C(O)-X1 80, -NH-C(O)-O-X1 81, -NH-C(O)-NH-X1 82, -NH C(O)-NX183X184, -NX185-C(O)-O-X186, -NX187-C(O)-NH-X188, -NX1 89-C(O)-NX1 90X1 91, -NHS(0 2 )-X1 92, -NX1 93S(0 2 )-X1 94, -S 5 X195, -S(O)-X196, -S(0 2 )-X197, -S(0 2 )NH-X198, -S(0 2 )NX199X200, -S(0 2 )O-X201, -P(O)(OX202)(OX203), -Si(X204)(X205)(X206)"; where X155, X156, X157, X158, X159, X160, X161, X162, X163, X164, X165, X166, X167, X168, X169, X170, X171, X172, X173, X174, X175, X176, X177, X178, X179, X180, X181, X182, X183, X184, X185, X186, 10 X187, X188, X189, X190, X191, X192, X193, X194, X195, X196, X197, X198, X199, X200, X201, X202, X203, X204, X205, X206 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X161, X162 and/or 15 X170, X171 and/or X183, X184 and/or X190, X191 and/or X199, X200 together may also form "heterocyclyl"; or one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted aryl", where "substituted aryl" is substituted by at least one 20 substituent selected identically or differently from the group consisting of: (d) "(C 9 -C 30 )alkyl, -NX207X208, -NH-(Cg-C 3 0 )alkyl, -NHC(O)-cycloalkylalkyl, NHC(O)-heterocyclylalkyl, -NHC(O)-(C 9 -C 30 )alkyl, -NX209C(O)-X210, NX21 1 C(O)-(C-C 30 )alkyl, -NHC(O)-OX212, -NX213C(O)-OX214, NHC(O)-NHX215, -NHC(O)-NX216X217, -NX218C(O)-NHX219, 25 NX220C(O)-NX221X222, -NHS(0 2 )-cycloalkylalkyl, -NHS(0 2 ) heterocyclylalkyl, -NX223S(0 2 )-X224, -O-(C-C 30 )alkyl, -S-cycloalkyl, -S heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl, -S-cycloalkylalkyl, -S heterocyclylalkyl, -S-(C 9 -C 30 )alkyl, -OC(O)-cycloalkylalkyl, -OC(O) heterocyclylalkyl, -OC(O)-(C-C 3 0 )alkyl, -OS(0 2 )-cycloalkylalkyl, -OS(0 2 ) 30 heterocyclylalkyl, -OS(O 2 )-(C-C 30 )alkyl, -OC(O)-OX225, -OC(O) NHX226, -OC(O)-NX227X228, -OP(O)(OX229)(OX230), -C(O)-cycloalkyl, -C(O)-heterocyclyl, -C(O)-arylalkyl, -C(O)-heteroarylalkyl, -C(O) cycloalkylalkyl, -C(O)-heterocyclylalkyl, -C(O)-(C 9 -C 30 )alkyl, -C(O)O-(C 9 - W02007/054556 PCT/EP2006/068322 - 303 C 30 )alkyl, -C(O)NH-(Cg-C 3 0 )alkyl, -C(O)NX231X232, -C(O)NH-OX233, C(O)NX234-OX235, -C(O)NH-NX236X237, -C(O)NX238-NX239X240, S(O)-cycloalkyl, -S(O)-heterocyclyl, -S(O)-heteroaryl, -S(O)-arylalkyl, S(O)-heteroarylalkyl, -S(O)-cycloalkylalkyl, -S(O)-heterocyclylalkyl, 5 S(O)-(Cg-C 30 )alkyl, -S(0 2 )-cycloalkyl, -S(0 2 )-heterocyclyl, -S(0 2 ) heteroaryl, -S(0 2 )-arylalkyl, -S(0 2 )-heteroarylalkyl, -S(0 2 )-cycloalkylalkyl, -S(0 2 )-heterocyclylalkyl, -S(0 2 )-(Cg-C 30 )alkyl, -S(0 2 )NH-cycloalkyl, S(0 2 )NH-heterocyclyl, -S(0 2 )NH-heteroarylalkyl, -S(0 2 )NH cycloalkylalkyl, -S(0 2 )NH-heterocyclylalkyl, -S(0 2 )NH-(C-C 3 0 )alkyl, 10 S(0 2 )O-cycloalkyl, -S(0 2 )O-heterocyclyl, -S(0 2 )O-heteroaryl, -S(0 2 )O heteroarylalkyl, -S(0 2 )O-cycloalkylalkyl, -S(0 2 )O-heterocyclylalkyl, S(0 2 )O-(C-C 3 0 )alkyl, -P(O)(OH)2, -P(O)(OX241)(OX242), Si(X243)(X244)(X245), -O-Si(X246)(X247)(X248)"; where X207, X208, X209, X210, X211, X212, X213, X214, X215, X216, 15 X217, X218, X219, X220, X221, X222, X223, X224, X225, X226, X227, X228, X229, X230, X231, X232, X233, X234, X235, X236, X237, X238, X239, X240, X241, X242, X243, X244, X245, X246, X247, X248 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 20 heteroaryl, heteroarylalkyl" and where, alternatively, X216, X217 and/or X221, X222 and/or X227, X228 and/or X231, X232 and/or X236, X237 and/or X239, X240, in each case together, may also form "heterocyclyl"; with the proviso that the substituents "-N(alkyl) 2 ", "-C(O)N(alkyl)2", C(O)N(cycloalkyl)2", "-C(O)N(aryl) 2 ", "-C(O)N(heteroaryl) 2 " are substituted 25 further by at least one substituent selected from the following substituent group (i); with the further proviso that when one of the Z3 or Z4 radicals is "substituted aryl" substituted by "heterocyclylalkyl", the other Z3 or Z4 radical in each case is not "unsubstituted or substituted aryl"; 30 where, optionally, the above substituents of substituent group (c) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 -304 (i) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX249, -NX250X251, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 5 P(O)(OH) 2 , -C(O)-X252, -C(O)O-X253, -C(O)NH-X254, C(O)NX255X256, -O-X257, -O(-X258-O),-H (u = 1, 2, 3, 4, 5), -O( X259-0),-X260 (u = 1, 2, 3, 4, 5), -OC(O)-X261, -OC(O)-O-X262, OC(O)-NHX263, -O-C(O)-NX264X265, -OP(O)(OX266)(OX267), OSi(X268)(X269)(X270), -OS(0 2 )-X271, -NHC(O)-X272, 10 NX273C(O)-X274, -NH-C(O)-O-X275, -NH-C(O)-NH-X276, -NH C(O)-NX277X278, -NX279-C(O)-O-X280, -NX281-C(O)-NH-X282, -NX283-C(O)-NX284X285, -NHS(0 2 )-X286, -NX287S(0 2 )-X288, -S X289, -S(O)-X290, -S(0 2 )-X291, -S(0 2 )NH-X292, -S(0 2 )NX293X294, -S(0 2 )O-X295, -P(O)(OX296)(OX297), -Si(X298)(X299)(X300)"; 15 where X249, X250, X251, X252, X253, X254, X255, X256, X257, X258, X259, X260, X261, X262, X263, X264, X265, X266, X267, X268, X269, X270, X271, X272, X273, X274, X275, X276, X277, X278, X279, X280, X281, X282, X283, X284, X285, X286, X287, X288, X289, X290, X291, X292, X293, X294, X295, X296, X297, X298, X299, X300 are each 20 independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X255, X256 and/or X264, X265 and/or X277, X278 and/or X284, X285 and/or X293, X294, in each case together, may also form "heterocyclyl"; 25 where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (d) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, 30 CF 3 , N 3 , NH 2 , -NHX301, -NX302X303, -NO 2 , -OH, -OCF 3 , -SH, -0 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-X304, -C(O)O-X305, -C(O)NH-X306, -C(O)NX307X308, -O-X309, -O(-X310-O)uu-H (uu = 1, 2, 3, 4, 5), -O(-X311-O)uu-X312 (uu = 1, 2, 3, 4, 5), -OC(O)-X313, -OC(O)-O-X314, -OC(O)-NHX315, -0-C(O)- W02007/054556 PCT/EP2006/068322 - 305 NX316X317, -OP(O)(OX318)(OX319), -OSi(X320)(X321)(X322), -OS(O 2 ) X323, -NHC(O)-X324, -NX325C(O)-X326, -NH-C(O)-O-X327, -NH C(O)-NH-X328, -NH-C(O)-NX329X330, -NX331-C(O)-O-X332, NX333-C(O)-NH-X334, -NX335-C(O)-NX336X337, -NHS(O 2 )-X338, 5 NX339S(0 2 )-X340, -S-X341, -S(O)-X342, -S(0 2 )-X343, -S(O 2 )NH X344, -S(0 2 )NX345X346, -S(O 2 )O-X347, -P(O)(OX348)(OX349), Si(X350)(X351)(X352)"; where X301, X302, X303, X304, X305, X306, X307, X308, X309, X310, X311, X312, X313, X314, X315, X316, X317, X318, X319, X320, X321, 10 X322, X323, X324, X325, X326, X327, X328, X329, X330, X331, X332, X333, X334, X335, X336, X337, X338, X339, X340, X341, X342, X343, X344, X345, X346, X347, X348, X349, X350, X351, X352 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 15 heteroaryl, heteroarylalky" and where, alternatively, X307, X308 and/or X316, X317 and/or X329, X330 and/or X336, X337 and/or X345, X346, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (d) may each independently in turn be substituted by at least one substituent selected 20 identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX353, -NX354X355, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 25 P(O)(OH) 2 , -C(O)-X356, -C(O)O-X357, -C(O)NH-X358, C(O)NX359X360, -O-X361, -O(-X362-0),-H (v = 1, 2, 3, 4, 5), -O( X363-0),-X364 (v = 1, 2, 3, 4, 5), -OC(O)-X365, -OC(O)-O-X366, OC(O)-NHX367, -O-C(O)-NX368X369, -OP(O)(OX370)(OX371), OSi(X372)(X373)(X374), -OS(0 2 )-X375, -NHC(O)-X376, 30 NX377C(O)-X378, -NH-C(O)-O-X379, -NH-C(O)-NH-X380, -NH C(O)-NX381X382, -NX383-C(O)-O-X384, -NX385-C(O)-NH-X386, -NX387-C(O)-NX388X389, -NH S(0 2 )-X390, -NX391S(0 2 )-X392, -S X393, -S(O)-X394, -S(0 2 )-X395, -S(0 2 )NH-X396, -S(0 2 )NX397X398, -S(0 2 )O-X399, -P(O)(OX400)(OX401), -Si(X402)(X403)(X404)"; WO2007/054556 -PCT/EP2006/068322 W0207/05556-306 where X353, X354, X355, X356, X357, X358, X359, X360, X361, X362, X363, X364, X365, X366, X367, X368, X369, X370, X371, X372, X373, X374, X375, X376, X377, X378, X379, X380, X381, X382, X383, X384, X385, X386, X387, X388, X389, X390, X391, X392, X393, X394, X395, 5 X396, X397, X398, X399, X400, X401, X402, X403, X404 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X359, X360 and/or X368, X369 and/or X381, X382 and/or X388, X389 and/or X397, X398, 10 in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX405, -NX406X407, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X408, -C(O)O-X409, -C(O)NH-X410, 20 C(O)NX411X412, -O-X413, -O(-X414-0),-H (w = 1, 2, 3, 4, 5), -O( X415-0).-X416 (w = 1, 2, 3, 4, 5), -OC(O)-X417, -OC(O)-O-X418, OC(O)-NHX419, -O-C(O)-NX420X421, -OP(O)(OX422)(OX423), OSi(X424)(X425)(X426), -OS(0 2 )-X427, -NHC(O)-X428, NX429C(O)-X430, -NH-C(O)-O-X431, -NH-C(O)-NH-X432, -NH 25 C(O)-NX433X434, -NX435-C(O)-O-X436, -NX437-C(O)-NH-X438, -NX439-C(O)-NX440X441, -NHS(0 2 )-X442, -NX443S(0 2 )-X444, -S X445, -S(O)-X446, -S(0 2 )-X447, -S(0 2 )NH-X448, -S(0 2 )NX449X450, -S(0 2 )O-X451, -P(O)(OX452)(OX453), -Si(X454)(X455)(X456)"; where X405, X406, X407, X408, X409, X410, X411, X412, X413, X414, 30 X415, X416, X417, X418, X419, X420, X421, X422, X423, X424, X425, X426, X427, X428, X429, X430, X431, X432, X433, X434, X435, X436, X437, X438, X439, X440, X441, X442, X443, X444, X445, X446, X447, X448, X449, X450, X451, X452, X453, X454, X455, X456 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, W02007/054556 PCTIEP2006/068322 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X41 1, X412 and/or X420, X421 and/or X433, X434 and/or X440, X441 and/or X449, X450, in each case together, may also form "heterocyclyl"; 5 and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently selected from the group consisting of: (e) hydrogen; (f) halogen, F, Cl, Br, 1; 10 (g) unsubstituted or substituted alkyl or (C 9 -C 30 )alkyl, where, optionally, the alkyl or (C 9 -C 30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, 15 CN, CF 3 , N 3 , NH 2 , -NHX457, -NX458X459, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X460, -C(O)O-X461, -C(O)NH-X462, C(O)NX463X464, -O-X465, -O(-X466-O),-H (x = 1, 2, 3, 4, 5), -O( X467-0),-X468 (x = 1, 2, 3, 4, 5), -OC(O)-X469, -OC(O)-O-X470, 20 OC(O)-NHX471, -0-C(0)-NX472X473, -OP(O)(OX474)(OX475), OSi(X476)(X477)(X478), -OS(0 2 )-X479, -NHC(O)-X480, NX481 C(O)-X482, -N H-C(O)-O-X483, -N H-C(O)-N H-X484, -NH C(O)-NX485X486, -NX487-C(O)-O-X48 8 , -NX489-C(O)-NH X490, -NX491-C(O)-NX492X493, -NHS(0 2 )-X494, -NX495S(0 2 ) 25 X496, -S-X497, -S(O)-X498, -S(0 2 )-X499, -S(0 2 )NH-X500, S(0 2 )NX501X502, -S(0 2 )O-X503, -P(O)(OX504)(OX505), Si(X506)(X507)(X508)"; where X457, X458, X459, X460, X461, X462, X463, X464, X465, X466, X467, X468, X469, X470, X471, X472, X473, X474, X475, 30 X476, X477, X478, X479, X480, X481, X482, X483, X484, X485, X486, X487, X488, X489, X490, X491, X492, X493, X494, X495, X496, X497, X498, X499, X500, X501, X502, X503, X504, X505, X506, X507, X508 are each independently selected from the group W02007/054556 PCT/EP2006/068322 - 308 consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X463, X464 and/or X472, X473 and/or X485, X486 and/or X492, X493 and/or X501, X502, in 5 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX509, -NX51OX511, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X512, -C(O)O-X513, -C(O)NH X514, -C(O)NX515X516, -O-X517, -O(-X518-O)y-H (y = 1, 2, 3, 15 4, 5), -O(-X519-O),-X520 (y = 1, 2, 3, 4, 5), -OC(O)-X521, OC(O)-O-X522, -OC(O)-NHX523, -O-C(O)-NX524X525, OP(O)(OX526)(OX527), -OSi(X528)(X529)(X530), -OS(O 2 ) X531, -NHC(O)-X532, -NX533C(O)-X534, -NH-C(O)-O-X535, -NH-C(O)-NH-X536, -NH-C(O)-NX537X538, -NX539-C(O)-O 20 X540, -NX541-C(O)-NH-X542, -NX543-C(O)-NX544X545, NHS(0 2 )-X546, -NX547S(0 2 )-X548, -S-X549, -S(O)-X550, S(0 2 )-X551, -S(0 2 )NH-X552, -S(0 2 )NX553X554, -S(0 2 )O X555, -P(O)(OX556)(OX557), -Si(X558)(X559)(X560)"; where X509, X510, X511, X512, X513, X514, X515, X516, X517, 25 X518, X519, X520, X521, X522, X523, X524, X525, X526, X527, X528, X529, X530, X531, X532, X533, X534, X535, X536, X537, X538, X539, X540, X541, X542, X543, X544, X545, X546, X547, X548, X549, X550, X551, X552, X553, X554, X555, X556, X557, X558, X559, X560 are each independently selected from the group 30 consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X515, X516 and/or X524, X525 and/or X537, X538 and/or X544, X545 and/or X553, X554, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -309 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHX561, -NX562X563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X564, -C(O)O-X565, 10 C(O)NH-X566, -C(O)NX567X568, -O-X569, -O(-X570-0)z H (z = 1, 2, 3, 4, 5), -O(-X571-0)z-X572 (z = 1, 2, 3, 4, 5), OC(O)-X573, -OC(O)-O-X574, -OC(O)-N HX575, -0-C(O) NX576X577, -OP(O)(OX578)(OX579), OSi(X580)(X581)(X582), -OS(0 2 )-X583, -NHC(O)-X584, 15 NX585C(O)-X586, -NH-C(O)-O-X587, -NH-C(O)-NH X588, -NH-C(O)-NX589X590, -NX591-C(O)-O-X592, NX593-C(O)-NH-X594, -NX595-C(O)-NX596X597, NHS(0 2 )-X598, -NX599S(0 2 )-X600, -S-X601, -S(O)-X602, -S(O 2 )-X603, -S(0 2 )NH-X604, -S(0 2 )NX605X606, -S(O2)O 20 X607, -P(O)(OX608)(OX609), -Si(X61 0)(X61 1)(X612)"; where X561, X562, X563, X564, X565, X566, X567, X568, X569, X570, X571, X572, X573, X574, X575, X576, X577, X578, X579, X580, X581, X582, X583, X584, X585, X586, X587, X588, X589, X590, X591, X592, X593, X594, X595, 25 X596, X597, X598, X599, X600, X601, X602, X603, X604, X605, X606, X607, X608, X609, X610, X611, X612 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 30 where, alternatively, X567, X568 and/or X576, X577 and/or X589, X590 and/or X596, X597 and/or X605, X606, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 310 (h) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX613, -NX614X615, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-X616, -C(O)O-X617, -C(O)NH-X618, C(O)NX619X620, -O-X621, -O(-X622-0)a-H (a = 1, 2, 3, 4, 5), -O( 10 X623-0),-X624 (a = 1, 2, 3, 4, 5), -OC(O)-X625, -OC(O)-O-X626, OC(O)-NHX627, -O-C(O)-NX628X629, -OP(O)(OX630)(OX631), OSi(X632)(X633)(X634), -OS(0 2 )-X635, -NHC(O)-X636, NX637C(O)-X638, -NH-C(O)-O-X639, -NH-C(O)-NH-X640, -NH C(O)-NX641X642, -NX643-C(O)-O-X644, -NX645-C(O)-NH 15 X646, -NX647-C(O)-NX648X649, -NHS(0 2 )-X650, -NX651S(0 2 ) X652, -S-X653, -S(O)-X654, -S(0 2 )-X655, -S(0 2 )NH-X656, S(0 2 )NX657X658, -S(0 2 )O-X659, -P(O)(OX660)(OX661), Si(X662)(X663)(X664)"; where X613, X614, X615, X616, X617, X618, X619, X620, X621, 20 X622, X623, X624, X625, X626, X627, X628, X629, X630, X631, X632, X633, X634, X635, X636, X637, X638, X639, X640, X641, X642, X643, X644, X645, X646, X647, X648, X649, X650, X651, X652, X653, X654, X655, X656, X657, X658, X659, X660, X661, X662, X663, X664 are each independently selected from the group 25 consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X619, X620 and/or X628, X629 and/or X641, X642 and/or X648, X649 and/or X657, X658, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 -311 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX665, -NX666X667, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 5 -SO 3 H, -P(O)(OH)2, -C(O)-X668, -C(O)O-X669, -C(O)NH X670, -C(O)NX671X672, -O-X673, -O(-X674-O)b-H (b = 1, 2, 3, 4, 5), -O(-X675-O)b-X67 6 (b = 1, 2, 3, 4, 5), -OC(O)-X677, OC(O)-O-X678, -OC(O)-NHX679, -O-C(O)-NX680X681, OP(O)(OX682)(OX683), -OSi(X684)(X685)(X686), -OS(0 2 ) 10 X687, -NHC(O)-X688, -NX689C(O)-X690, -NH-C(O)-O-X691, -NH-C(O)-NH-X692, -NH-C(O)-NX693X694, -NX695-C(O)-O X696, -NX697-C(O)-NH-X698, -NX699-C(O)-NX700X701, NHS(0 2 )-X702, -NX703S(0 2 )-X704, -S-X705, -S(O)-X706, S(0 2 )-X707, -S(0 2 )N H-X708, -S(0 2 )NX709X710, -S(0 2 )O 15 X71 1, -P(O)(OX712)(OX713), -Si(X714)(X715)(X716)"; where X665, X666, X667, X668, X669, X670, X671, X672, X673, X674, X675, X676, X677, X678, X679, X680, X681, X682, X683, X684, X685, X686, X687, X688, X689, X690, X691, X692, X693, X694, X695, X696, X697, X698, X699, X700, X701, X702, X703, 20 X704, X705, X706, X707, X708, X709, X710, X711, X712, X713, X714, X715, X716 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X671, X672 and/or X680, 25 X681 and/or X693, X694 and/or X700, X701 and/or X709, X710, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 30 consisting of: (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHX717, -NX718X719, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, - W02007/054556 PCT/EP2006/068322 - 312 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X720, -C(O)O-X721, C(O)NH-X722, -C(O)NX723X724, -O-X725, -O(-X726-0)c H (c = 1, 2, 3, 4, 5), -O(-X727-O)c-X728 (c = 1, 2, 3, 4, 5), OC(O)-X729, -OC(O)-O-X730, -OC(O)-NHX731, -0-C(O) 5 NX732X733, -OP(O)(OX734)(OX735), OSi(X736)(X737)(X738), -OS(0 2 )-X739, -NHC(O)-X740, NX741C(O)-X742, -NH-C(O)-O-X743, -NH-C(O)-NH X744, -NH-C(O)-NX745X746, -NX747-C(O)-O-X748, NX749-C(O)-NH-X750, -NX751-C(O)-NX752X753, 10 NHS(0 2 )-X754, -NX755S(0 2 )-X756, -S-X757, -S(O)-X758, -S(0 2 )-X759, -S(0 2 )NH-X760, -S(0 2 )NX761X762, -S(0 2 )O X763, -P(O)(OX764)(OX765), -Si(X766)(X767)(X768)"; where X717, X718, X719, X720, X721, X722, X723, X724, X725, X726, X727, X728, X729, X730, X731, X732, X733, 15 X734, X735, X736, X737, X738, X739, X740, X741, X742, X743, X744, X745, X746, X747, X748, X749, X750, X751, X752, X753, X754, X755, X756, X757, X758, X759, X760, X761, X762, X763, X764, X765, X766, X767, X768 are each independently selected from the group consisting of: "alkyl, 20 (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X723, X724 and/or X732, X733 and/or X745, X746 and/or X752, X753 and/or X761, X762, in each case together, may also form "heterocyclyl"; 25 (j) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX769, -NX770X771, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH)2, -C(O)-X772, -C(O)O-X773, -C(O)NH-X774, - W02007/054556 PCT/EP2006/068322 -313 C(O)NX775X776, -O-X777, -O(-X778-O)d-H (d = 1, 2, 3, 4, 5), -O( X779-0),-X 78 0 (d = 1, 2, 3, 4, 5), -OC(O)-X781, -OC(O)-O-X782, OC(O)-NHX783, -O-C(O)-NX784X785, -OP(O)(OX786)(OX787), OSi(X788)(X789)(X790), -OS(O 2 )-X791, -NHC(O)-X792, 5 NX793C(O)-X794, -NH-C(O)-O-X795, -NH-C(O)-NH-X796, -NH C(O)-NX797X798, -NX799-C(O)-O-X800, -NX801-C(O)-NH X802, -NX803-C(O)-NX804X805, -NHS(0 2 )-X806, -NX807S(0 2 ) X808, -S-X809, -S(O)-X810, -S(0 2 )-X811, -S(0 2 )NH-X812, S(0 2 )NX813X814, -S(0 2 )O-X815, -P(O)(OX816)(OX817), 10 Si(X818)(X819)(X820)"; where X769, X770, X771, X772, X773, X774, X775, X776, X777, X778, X779, X780, X781, X782, X783, X784, X785, X786, X787, X788, X789, X790, X791, X792, X793, X794, X795, X796, X797, X798, X799, X800, X801, X802, X803, X804, X805, X806, X807, 15 X808, X809, X810, X81 1, X812, X813, X814, X815, X816, X817, X818, X819, X820 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X775, X776 and/or X784, 20 X785 and/or X797, X798 and/or X804, X805 and/or X813, X814, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 25 (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX821, -NX822X823, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH)2, -C(O)-X824, -C(O)O-X825, -C(O)NH 30 X826, -C(O)NX827X828, -O-X829, -0(-X830-0)e-H (e = 1, 2, 3, 4, 5), -0(-X831-O)e-X832 (e = 1, 2, 3, 4, 5), -OC(O)-X833, OC(O)-O-X834, -OC(O)-NHX835, -O-C(O)-NX836X837, OP(O)(OX838)(OX839), -OSi(X840)(X841)(X842), -OS(0 2 ) X843, -NH C(O)-X844, -NX845C(O)-X846, -NH-C(O)-O-X847, W02007/054556 PCT/EP2006/068322 - 314 -NH-C(O)-NH-X848, -NH-C(O)-NX849X850, -NX851-C(O)-O X852, -NX853-C(O)-NH-X854, -NX855-C(O)-NX856X857, NHS(0 2 )-X858, -NX859S(0 2 )-X860, -S-X861, -S(O)-X862, S(0 2 )-X863, -S(0 2 )NH-X864, -S(0 2 )NX865X866, -S(0 2 )O 5 X867, -P(O)(OX868)(OX869), -Si(X870)(X871)(X872)"; where X821, X822, X823, X824, X825, X826, X827, X828, X829, X830, X831, X832, X833, X834, X835, X836, X837, X838, X839, X840, X841, X842, X843, X844, X845, X846, X847, X848, X849, X850, X851, X852, X853, X854, X855, X856, X857, X858, X859, 10 X860, X861, X862, X863, X864, X865, X866, X867, X868, X869, X870, X871, X872 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X827, X828 and/or X836, 15 X837 and/or X849, X850 and/or X856, X857 and/or X865, X866, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 20 consisting of: (iii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX873, -NX874X875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 25 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X876, -C(O)O-X877, C(O)NH-X878, -C(O)NX879X880, -O-X881, -O(-X882-0)r H (f = 1, 2, 3, 4, 5), -O(-X883-O)f-X 8 8 4 (f = 1, 2, 3, 4, 5), OC(O)-X885, -OC(O)-O-X886, -OC(O)-NHX887, -0-C(O) NX888X889, -OP(O)(OX890)(OX891), 30 OSi(X892)(X893)(X894), -OS(0 2 )-X895, -NHC(O)-X896, NX897C(O)-X898, -N H-C(O)-O-X899, -NH-C(O)-NH X900, -NH-C(O)-NX901X902, -NX903-C(O)-0-X904, NX905-C(O)-NH-X906, -NX907-C(O)-NX908X909, NHS(0 2 )-X91 0, -NX91 1 S(O 2 )-X912, -S-X913, -S(O)-X914, W02007/054556 -315- PCT/EP2006/068322 -S(0 2 )-X915, -S(0 2 )NH-X916, -S(0 2 )NX917X918, -S(0 2 )O X9 19, -P(O)(OX920)(OX92 1), -Si(X922)(X923)(X924)"; where X873, X874, X875, X876, X877, X878, X879, X880, X881, X882, X883, X884, X885, X886, X887, X888, X889, 5 X890, X891, X892, X893, X894, X895, X896, X897, X898, X899, X900, X901, X902, X903, X904, X905, X906, X907, X908, X909, X910, X911, X912, X913, X914, X915, X916, X917, X918, X919, X920, X921, X922, X923, X924 are each independently selected from the group consisting of: alkyll, 10 (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X879, X880 and/or X888, X889 and/or X901, X902 and/or X908, X909 and/or X917, X918, in each case together, may also form "heterocyclyl"; 15 (k) OZ6 where Z6 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 20 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHX925, -NX926X927, -NO 2 , -OH, 25 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X928, -C(O)O-X929, -C(O)NH X930, -C(O)NX931X932, -O-X933, -O(-X934-O)g-H (g = 1, 2, 3, 4, 5), -0(-X935-0)g-X93 6 (g = 1, 2, 3, 4, 5), -OC(O)-X937, OC(O)-O-X938, -OC(O)-NHX939, -O-C(O)-NX940X941, 30 OP(O)(OX942)(OX943), -OSi(X944)(X945)(X946), -OS(0 2 ) X947, -NH C(O)-X948, -NX949C(O)-X950, -NH-C(O)-O-X951, -NH-C(O)-NH-X952, -NH-C(O)-NX953X954, -NX955-C(O)-O X956, -NX957-C(O)-NH-X958, -NX959-C(O)-NX960X961, - W02007/054556 -316- PCT/EP2006/068322 NHS(0 2 )-X962, -NX963S(0 2 )-X964, -S-X965, -S(O)-X966, S(0 2 )-X967, -S(0 2 )NH-X968, -S(0 2 )NX969X970, -S(0 2 )O X971, -P(O)(OX972)(OX973), -Si(X974)(X975)(X976)"; where X925, X926, X927, X928, X929, X930, X931, X932, X933, 5 X934, X935, X936, X937, X938, X939, X940, X941, X942, X943, X944, X945, X946, X947, X948, X949, X950, X951, X952, X953, X954, X955, X956, X957, X958, X959, X960, X961, X962, X963, X964, X965, X966, X967, X968, X969, X970, X971, X972, X973, X974, X975, X976 are each independently selected from the group 10 consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X931, X932 and/or X940, X941 and/or X953, X954 and/or X960, X961 and/or X969, X970, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX977, -NX978X979, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X980, -C(O)O-X981, C(O)NH-X982, -C(O)NX983X984, -O-X985, -O(-X986-O)h 25 H (h = 1, 2, 3, 4, 5), -O(-X987-O)h-X988 (h = 1, 2, 3, 4, 5), OC(O)-X989, -OC(O)-O-X990, -OC(O)-NHX991, -0-C(O) NX992X993, -OP(O)(OX994)(OX995), OSi(X996)(X997)(X998), -OS(0 2 )-X999, -NHC(O)-X1000, NX1001C(O)-X1002, -NH-C(O)-0-X1003, -NH-C(O)-NH 30 X1004, -NH-C(O)-NX1005X1006, -NX1007-C(O)-O-X1008, -NX1009-C(O)-NH-X1010, -NX1011-C(O)-NX1012X1013, NHS(0 2 )-X1014, -NX1015S(O 2 )-X1016, -S-X1017, -S(O) X1018, -S(0 2 )-X1019, -S(0 2 )NH-X1020, - W02007/054556 -317- PCT/EP2006/068322 S(0 2 )NX1021X1022, -S(0 2 )O-X1023, P(O)(OX1024)(OX1025), -Si(X1026)(X1027)(X1028)"; where X977, X978, X979, X980, X981, X982, X983, X984, X985, X986, X987, X988, X989, X990, X991, X992, X993, 5 X994, X995, X996, X997, X998, X999, X1000, X1001, X1002, X1003, X1004, X1005, X1006, X1007, X1008, X1009, X1010, X1011, X1012, X1013, X1014, X1015, X1016, X1017, X1018, X1019, X1020, X1021, X1022, X1023, X1024, X1025, X1026, X1027, X1028 are each independently selected from the group 10 consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X983, X984 and/or X992, X993 and/or X1005, X1006 and/or X1012, X1013 and/or X1 021, X1 022, in each case together, may also form 15 "heterocyclyl"; (1) SZ7 where Z7 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 20 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, 25 Br, I, CN, CF 3 , N 3 , NH 2 , -NHX1029, -NX1030X1031, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1 032, -C(O)O-X1033, C(O)NH-X1034, -C(O)NX1035X1036, -O-X1037, -O(-X1038 O)r-H (i = 1, 2, 3, 4, 5), -O(-X1039-O)-X1040 (i = 1, 2, 3, 4, 5), 30 OC(O)-X1041, -OC(O)-O-X1042, -OC(O)-NHX1043, -0-C(0) NX1044X1045, -OP(O)(OX1046)(OX1047), OSi(X1 048)(X1 049)(X1 050), -OS(0 2 )-X1 051, -NHC(O)-X1 052, NX1053C(O)-X1054, -NH-C(O)-O-X1055, -NH-C(O)-NH- W02007/054556 -318- PCT/EP2006/068322 X1056, -NH-C(O)-NX1057X1058, -NX1059-C(O)-O-X1060, NX1061-C(O)-NH-X1062, -NX1063-C(O)-NX1064X1065, NHS(0 2 )-X1066, -NX1067S(0 2 )-X1068, -S-X1069, -S(O) X1 070, -S(0 2 )-X1 071, -S(0 2 )NH-X1 072, -S(0 2 )NX1 073X1 074, 5 S(0 2 )O-X1075, -P(O)(OX1 076)(OX1077), Si(X1 078)(X1 079)(X1 080)"; where X1029, X1030, X1031, X1032, X1033, X1034, X1035, X1036, X1037, X1038, X1039, X1040, X1041, X1042, X1043, X1044, X1045, X1046, X1047, X1048, X1049, X1050, X1051, 10 X1052, X1053, X1054, X1055, X1056, X1057, X1058, X1059, X1060, X1061, X1062, X1063, X1064, X1065, X1066, X1067, X1068, X1069, X1070, X1071, X1072, X1073, X1074, X1075, X1076, X1077, X1078, X1079, X1080 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, 15 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1035, X1036 and/or X1044, X1045 and/or X1057, X1058 and/or X1064, X1065 and/or X1073, X1074, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX1081, -NX1082X1083, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1 084, -C(0)0 X1085, -C(O)NH-X1086, -C(O)NX1087X1 088, -O-X1 089, 30 O(-X1090-O);-H (j = 1, 2, 3, 4, 5), -O(-X1091-O)j-Xl0 92 ( = 1, 2, 3, 4, 5), -OC(O)-X1 093, -OC(O)-O-X1094, -OC(O) NHX1095, -O-C(O)-NX1096X1097, OP(O)(OX1 098)(OX1 099), -OSi(X1 1 00)(X1 101)(X1 102), OS(0 2 )-X1 103, -NHC(O)-X1 104, -NX1 105C(O)-X1 106, - W02007/054556 -319- PCT/EP2006/068322 NH-C(O)-O-X1 107, -NH-C(O)-NH-X1 108, -NH-C(O) NX1 109X1 110, -NX1 11 1-C(0)-0-X1 112, -NXII1113-C(O) NH-X1114, -NX1115-C(O)-NX1116X1117, -NHS(0 2 ) X1118, -NX1119S(0 2 )-X1120, -S-X1121, -S(O)-X1122, 5 S(0 2 )-X1123, -S(0 2 )NH-X1124, -S(0 2 )NX1125X1126, S(0 2 )0-X1 127, -P(O)(OX1 128)(OX1 129), Si(X1 130)(X1 131)(X1 132)"; where X1081, X1082, X1083, X1084, X1085, X1086, X1087, X1 088, X1 089, X1090, X1 091, X1092, X1093, X1094, X1095, 10 X1096, X1097, X1098, X1099, X1100, X1101, X1102, X110 3 , X1104, X1105, X1106, X1107, X1108, X1109, X111O, X1111, X1112, X1113, X1114, X1115, X1116, X1117, X1118, X1119, X1120, X1121, X1122, X1123, X1124, X1125, X1126, X1127, X1128, X1129, X1130, X1131, X1132 are each independently 15 selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1 087, X1 088 and/or X1 096, X1 097 and/or X1109, X1 110 and/or X1116, X1117 and/or X1125, X1126, in each case 20 together, may also form "heterocyclyl"; (m) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: (ii) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) X1133, -C(O)O-X1134, -C(O)-NX1135X1136, -S(0 2 )-X1137, S(0 2 )O-X1 138"; where X1133, X1134, X1135, X1136, X1137, X1138 are each independently selected from the group consisting of: hydrogen, alkyl, 30 (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1i135, X1i136 together may also form "heterocyclyl"; W02007/054556 -320- PCT/EP2006/068322 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHX1139, -NX1140X1 141, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1 142, -C(O)O-X1 143, C(O)NH-X1144, -C(O)NX1145X1146, -O-X1147, -O(-X1148 10 O)k-H (k = 1, 2, 3, 4, 5), -O(-X1149-O)k-X115 0 (k = 1, 2, 3, 4, 5), -OC(O)-X1 151, -OC(O)-O-X1 152, -OC(O)-NHXI 153, -0 C(O)-NX1 154X1 155, -OP(O)(OX1 156)(OX1 157), OSi(X 158)(X1 159)(X1 160), -OS(0 2 )-X1 161, -NHC(O)-X1 162, NX1 163C(O)-X1 164, -NH-C(O)-O-X1 165, -NH-C(O)-NH 15 X1166, -NH-C(O)-NX1167X1168, -NX1169-C(O)-O-X117 0 , NX1171-C(O)-NH-X1172, -NX1173-C(O)-NX1174X1175, NHS(0 2 )-X1176, -NX1177S(0 2 )-X1178, -S-X1179, -S(O) Xi 180, -S(0 2 )-X1 181, -S(0 2 )NH-X1 182, -S(0 2 )NX1 183X1 184, S(0 2 )O-X1 185, -P(O)(OX1 186)(OX1 187), 20 Si(X1 188)(X1 189)(X1 190)"; where X1139, X1140, X1141, X1142, X1143, X1144, X1145, X1146, X1147, X1148, X1149, X1150, X1151, X1152, X1153, X1154, X1155, X1156, X1157, X1158, X1159, X1160, X1161, X1162, X1163, X1164, X1165, X1166, X1167, X1168, X1169, 25 X1170,X1171,X1172,X1173,X1174,X1175,X1176,X1177, X1178, X1179, X1180, X1181, X1182, X1183, X1184, X1185, X1186, X1l187, X1188, X1189, X1190 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 30 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, X1145, X1146 and/or XI154, X1155 and/or X1167, X1168 and/or X1174, X1175 and/or X1183, X1184, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 321 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHX1191, -NX1192X1193, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-X1 194, -C(O)O 10 X1195, -C(O)NH-X1196, -C(O)NX1197X1198, -O-X11 99 , O(-X1200-O)rH (I = 1, 2, 3, 4, 5), -O(-X1201-O)r-X120 2 (I = 1, 2, 3, 4, 5), -OC(O)-X1203, -OC(O)-O-X1204, -OC(O) NHX1205, -O-C(O)-NX1206X1207, OP(O)(OX1208)(OX1 209), -OSi(X1 21 0)(X121 1)(X1 212), 15 OS(0 2 )-X1213, -NHC(O)-X1214, -NX1215C(O)-X1216, NH-C(O)-O-X1217, -NH-C(O)-NH-X1218, -NH-C(O) NX1219X1220, -NX1221-C(O)-O-X1222, -NX1223-C(O) NH-X1224, -NX1225-C(O)-NX1226X1227, -NHS(0 2 ) X1228, -NX1229S(0 2 )-X1230, -S-X1231, -S(O)-X1232, 20 S(0 2 )-X1233, -S(0 2 )NH-X1234, -S(0 2 )NX1235X1236, S(0 2 )O-X1237, -P(O)(OX1238)(OX1239), Si(X1240)(X1241)(X1242)"; where X1191, X1192, X1193, X1194, X1195, X1196, X1197, X1198, X1199, X1200, X1201, X1202, X1203, X1204, X1205, 25 X1206, X1207, X1208, X1209, X1210, X1211, X1212, X1213, X1214, X1215, X1216, X1217, X1218, X1219, X1220, X1221, X1222, X1223, X1224, X1225, X1226, X1227, X1228, X1229, X1230, X1231, X1232, X1233, X1234, X1235, X1236, X1237, X1238, X1239, X1240, X1241, X1242 are each independently 30 selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylakyl" and where, alternatively, X1197, X1198 and/or X1206, X1207 and/or X121 9 , X1220 W02007/054556 -322- PCT/EP2006/068322 and/or X1 226, X1227 and/or X1235, X1 236, in each case together, may also form "heterocyclyl"; or 5 (B) one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted heteroaryl", where "substituted heteroaryl" is substituted by at least one substituent selected from the group consisting of: (a) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -NH-V1, -N(alkyl) 2 , 10 NHC(O)-alkyl, -NHC(O)-cycloalkyl, -NHC(O)-heterocyclyl, -NHC(O)-aryl, -NHC(O)-heteroaryl, -NHC(O)-arylalkyl, -NHC(O)-heteroarylalkyl, NHS(0 2 )-alkyl, -NHS(0 2 )-cycloalkyl, -NHS(0 2 )-heterocyclyl, -NHS(0 2 ) aryl, -NHS(0 2 )-heteroaryl, -NHS(0 2 )-arylalkyl, -NHS(O 2 )-heteroarylalkyl, -S-alkyl, -S-aryl, -S-heteroaryl, -0-alkyl, -0-cycloalkyl, -0 15 cycloalkylalkyl, -0-aryl, -0-arylalkyl, -0-heteroaryl, -0-heteroarylalkyl, 0-heterocyclylalkyl, -OC(O)-alkyl, -OC(O)-cycloalkyl, -OC(O) heterocyclyl, -OC(O)-aryl, -OC(O)-heteroaryl, -OC(O)-arylalkyl, -OC(O) heteroarylalkyl, -OS(0 2 )-alkyl, -OS(0 2 )-cycloalkyl, -OS(0 2 )-heterocyclyl, -OS(0 2 )-aryl, -OS(0 2 )-heteroaryl, -OS(0 2 )-arylalkyl, -OS(0 2 ) 20 heteroarylalkyl, -C(O)-alkyl, -C(O)-aryl, -C(O)-heteroaryl, -C(O)O-V2, C(O)NH-V3, -C(O)N(alkyl) 2 , -C(O)N(cycloalkyl) 2 , -C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , -S(0 2 )NH-alkyl, -S(0 2 )NH-aryl, -S(0 2 )NH-heteroaryl, -S(0 2 )NH-arylalkyl, -S(0 2 )O-alkyl, -S(0 2 )O-aryl, -S(O 2 )O-arylalkyl"; where V1, V2, V3 are each independently selected from the group 25 consisting of: "alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; with the proviso that the above substituents of substituent group (a) are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: 30 (ii) "(C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N 3 , -NH-cycloalkyl, -NH cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, - W02007/054556 -323- PCT/EP2006/068322 NH-heterocyclyl, -NH-heterocyclylalkyl, -NV4V5, -S-cycloalkyl, -S cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -0-cycloalkyl, -0 cycloalkylalkyl, -0-arylalkyl, -0-heteroaryl, -0-heteroarylalkyl, -0 5 heterocyclyl, -0-heterocyclylalkyl, -O(-V6-O)0-H (p = 1, 2, 3, 4, 5), O(-V7-O)p-V8 (p = 1, 2, 3, 4, 5), -OP(O)(OV9)(OV1 0), -C(O)O-V 11, C(O)NH 2 , -C(O)NH-V12, -C(O)NV13V14, -S(0 2 )-V15, -P(O)(OH) 2 , P(O)(OV1 6)(OV1 7), -Si(V1 8)(V1 9)(V20), -O-Si(V21)(V22)(V23), -0 C(O)-O-V24, -0-C(O)-NH-V25, -O-C(O)-NV26V27, -NH-C(O)-O 10 V28, -NH-C(O)-NH-V29, -NH-C(O)-NV3OV31, -NV32-C(O)-O-V33, -NV34-C(O)-NH-V35, -NV36-C(O)-NV37V38, -NV39-S(0 2 )-V40, NH-S(0 2 )-V41, -O-S(0 2 )-V42, -NH-C(O)-V43, -NV44-C(O)-V45, C(O)-V46, -OC(O)-V47, -S(O)-V48, -S(0 2 )-NHV49, -S(0 2 ) NV50V51, -S(0 2 )-OV52"; 15 with the further proviso that "-N(alkyl) 2 " is further substituted by at least one substituent selected from the following substituent group (b); where V4, V5, V6, V7, V8, V9, V10, V11, V12, V13, V14, V15, V16, V17, V18, V19, V20, V21, V22, V23, V24, V25, V26, V27, V28, V29, V30, V31, V32, V33, V34, V35, V36, V37, V38, V39, V40, V41, V42, V43, 20 V44, V45, V46, V47, V48, V49, V50, V51, V52 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V13, V14 and/or V26, V27 and/or V30, V31 and/or V37, V38 and/or V50, V51 together may also 25 form "heterocyclyl"; where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (b) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV53, -NV54V55, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V56, -C(O)O-V57, -C(O)NH-V58, -C(O)NV59V60, -O-V61, -O(-V62-O)r-H (r W02007/054556 -324- PCT/EP2006/068322 = 1, 2, 3, 4, 5), -O(-V63-0),-V64 (r = 1, 2, 3, 4, 5), -OC(O)-V65, -OC(O) O-V66, -OC(O)-NHV67, -0-C(O)-NV68V69, -OP(O)(OV70)(OV71), OSi(V72)(V73)(V74), -OS(0 2 )-V75, -NHC(O)-V76, -NV77C(O)-V78, NH-C(O)-O-V79, -NH-C(O)-NH-V80, -NH-C(O)-NV81V82, -NV83 5 C(O)-O-V84, -NV85-C(O)-NH-V86, -NV87-C(O)-NV88V89, -NIHS(O 2 ) V90, -NV91S(0 2 )-V92, -S-V93, -S(O)-V94, -S(0 2 )-V95, -S(0 2 )NH-V96, -S(0 2 )NV97V98, -S(0 2 )O-V99, -P(O)(OV100)(OV101), Si(V1 02)(V1 03)(V1 04)"; where V53, V54, V55, V56, V57, V58, V59, V60, V61, V62, V63, V64, V65, 10 V66, V67, V68, V69, V70, V71, V72, V73, V74, V75, V76, V77, V78, V79, V80, V81, V82, V83, V84, V85, V86, V87, V88, V89, V90, V91, V92, V93, V94, V95, V96, V97, V98, V99, V100, V101, V102, V103, V104 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 15 heteroaryl, heteroarylalkyl" and where, alternatively, V59, V60 and/or V68, V69 and/or V81, V82 and/or V88, V89 and/or V97, V98 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (b) may each independently in turn be substituted by at least one substituent selected 20 identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV105, -NV106V107, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 25 P(O)(OH) 2 , -C(O)-V108, -C(O)O-V109, -C(O)NH-V110, C(O)NV111V112, -O-V113, -O(-V114-0),-H (s = 1, 2, 3, 4, 5), -O( V115-0),-V116 (s = 1, 2, 3, 4, 5), -OC(O)-V117, -OC(O)-O-V118, OC(O)-NHV1 19, -O-C(O)-NV120V121, -OP(O)(OV122)(OV123), OSi(V124)(V125)(V126), -OS(O 2 )-V127, -NHC(O)-V128, 30 NV129C(O)-V130, -NH-C(O)-O-V131, -NH-C(O)-NH-V132, -NH C(O)-NV1 33V1 34, -NV1 35-C(O)-O-V1 36, -NV1 37-C(O)-NH-V1 38, -NV139-C(O)-NV140V141, -NHS(0 2 )-V142, -NV143S(0 2 )-V144, -S V145, -S(O)-V146, -S(0 2 )-V147, -S(0 2 )NH-V148, -S(0 2 )NV149V150, -S(0 2 )O-V1 51, -P(O)(OV1 52)(OV1 53), -Si(V1 54)(V1 55)(V1 56)"; W02007/054556 -325- PCT/EP2006/068322 where V105, V106, V107, V108, V109, V110, Vil, V112, V11 3 , V114, V115, V116, V117, V118, V119, V120, V121, V122, V123, V124, V125, V126, V127, V128, V129, V130, V131, V132, V133, V134, V135, V136, V137, V138, V139, V140, V141, V142, V143, V144, V145, V146, V147, 5 V148, V149, V150, V151, V152, V153, V154, V155, V156 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V111, V112 and/or V120, V121 and/or V133, V134 and/or V140, V141 and/or V149, V150 10 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV157, -NV158V159, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V160, -C(O)O-V161, -C(O)NH-V162, 20 C(O)NV163V164, -O-V65, -O(-V166-O)i-H (t = 1, 2, 3, 4, 5), -O( V167-O)t-V168 (t = 1, 2, 3, 4, 5), -OC(O)-V169, -OC(O)-O-V170, OC(O)-NHV1 71, -0-C(O)-NV1 72V1 73, -OP(O)(OV1 74)(OV1 75), OSi(V176)(V177)(V178), -OS(0 2 )-V179, -NHC(O)-V180, NV181C(O)-V182, -NH-C(O)-O-V183, -NH-C(O)-NH-V184, -NH 25 C(O)-NV185V186, -NV187-C(O)-O-V188, -NV189-C(O)-NH-V190, -NV191-C(O)-NV192V193, -NHS(0 2 )-V194, -NV195S(O 2 )-V196, -S V197, -S(O)-V198, -S(0 2 )-V199, -S(0 2 )NH-V200, -S(0 2 )NV201V202, -S(0 2 )O-V203, -P(O)(OV204)(OV205), -Si(V206)(V207)(V208)"; where V157, V158, V159, V160, V161, V162, V163, V164, V165, V166, 30 V167, Vi68, Vi69, Vi7O, V171, V172, V173, V174, V175, V176, V177, V178, V179, Vi8O, V181, V182, V183, V184, V185, V186, V187, Vi88, V189, V190, V191, V192, V193, V194, V195, V196, V197, V198, V199, V200, V201, V202, V203, V204, V205, V206, V207, V208 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, W02007/054556 PCT/EP2006/068322 - 326 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V163, V164 and/or V172, V173 and/or V185, V186 and/or V192, V193 and/or V201, V202 together may also form "heterocyclyl"; 5 or one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted heteroaryl", where "substituted heteroaryl" is substituted by at least one substituent selected identically or differently from the group consisting of: (c) "(C 9 -C 30 )alkyl, -NV209V210, -NH-(C 9 -C 30 )alkyl, -NHC(O)-cycloalkylalkyl, 10 NHC(0)-heterocyclylalkyl, -NHC(O)-(C-C 30 )alkyl, -NV21 1 C(O)-V212, NV213C(O)-(C-C 30 )alkyl, -NHC(0)-OV214, -NV215C(O)-OV216, NHC(O)-NHV217, -NHC(O)-NV218V219, -NV220C(O)-NHV221, NV222C(O)-NV223V224, -NHS(0 2 )-cycloalkylalkyl, -NHS(0 2 ) heterocyclylalkyl, -NV225S(0 2 )-V226, -0-heterocyclyl, -O-(C 9 -C 30 )alkyl, 15 S-cycloalkyl, -S-heterocyclyl, -S-arylalkyl, -S-heteroarylalkyl, -S cycloalkylalkyl, -S-heterocyclylalkyl, -S-(C-C 30 )alkyl, -OC(O) cycloalkylalkyl, -OC(O)-heterocyclylalkyl, -OC(O)-(C 9 -C 30 )alkyl, -OC(O) OV227, -OC(O)-NHV228, -OC(O)-NV229V230, -OP(O)(OV231)(OV232), -OS(0 2 )-cycloalkylalkyl, -OS(0 2 )-heterocyclylalkyl, -OS(0 2 )-(Cg-C 3 0 )alkyl, 20 -C(O)-cycloalkyl, -C(O)-heterocyclyl, -C(O)-arylalkyl, -C(O) heteroarylalkyl, -C(O)-cycloalkylalkyl, -C(O)-heterocyclylalkyl, -C(O)-(Cg C 30 )alkyl, -C(O)O-(C 9 -C 30 )alkyl, -C(0)NH-(C 9 -C 30 )alkyl, -C(O)NV233V234, -C(O)NH-OV235, -C(O)NV236-OV237, -C(O)NH-NV238V239, C(O)NV240-NV241V242, -S(O)-V243, -S(0 2 )-V244, -S(0 2 )NH 25 cycloalkyl, -S(0 2 )NH-heterocyclyl, -S(0 2 )NH-heteroarylalkyl, -S(0 2 )NH cycloalkylalkyl, -S(0 2 )NH-heterocyclylalkyl, -S(0 2 )NH-(C 9 -C 30 )alkyl, S(0 2 )O-cycloalkyl, -S(0 2 )O-heterocyclyl, -S(0 2 )O-heteroaryl, -S(0 2 )O heteroarylalkyl, -S(0 2 )O-cycloalkylalkyl, -S(0 2 )O-heterocyclylalkyl, S(0 2 )O-(Cg-C 30 )alkyl, -P(O)(OH)2, -P(O)(OV245)(OV246), 30 Si(V247)(V248)(V249), -0-Si(V250)(V251)(V252)"; where V209, V210, V211, V212, V213, V214, V215, V216, V217, V218, V219, V220, V221, V222, V223, V224, V225, V226, V227, V228, V229, V230, V231, V232, V233, V234, V235, V236, V237, V238, V239, V240, W02007/054556 PCT/EP2006/068322 - 327 V241, V242, V243, V244, V245, V246, V247, V248, V249, V250, V251, V252 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V218, V219 5 and/or V223, V224 and/or V229, V230 and/or V233, V234 and/or V238, V239 and/or V241, V242 together may also form "heterocyclyl"; with the proviso that the substituents "-N(alkyl) 2 ", "-C(O)N(alkyl) 2 ", C(O)N(cycloalkyl) 2 ", "-C(O)N(aryl) 2 ", "-C(O)N(heteroaryl) 2 " are substituted further by at least one substituent selected from the following substituent 10 group (i); where, optionally, the above substituents of substituent group (c) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV253, -NV254V255, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V256, -C(O)O-V257, -C(O)NH-V258, C(O)NV259V260, -O-V261, -0(-V262-O)u-H (u = 1, 2, 3, 4, 5), -O( 20 V263-O),-V264 (u = 1, 2, 3, 4, 5), -OC(O)-V265, -OC(O)-O-V266, OC(O)-NHV267, -O-C(O)-NV268V269, -OP(O)(OV270)(OV271), OSi(V272)(V273)(V274), -OS(0 2 )-V275, -NHC(O)-V276, NV277C(O)-V278, -NH-C(O)-O-V279, -NH-C(O)-NH-V280, -NH C(O)-NV281V282, -NV283-C(O)-O-V284, -NV285-C(O)-NH-V286, 25 -NV287-C(O)-NV288V289, -NHS(0 2 )-V290, -NV291S(0 2 )-V292, -S V293, -S(O)-V294, -S(0 2 )-V295, -S(0 2 )NH-V296, -S(0 2 )NV297V298, -S(0 2 )O-V299, -P(O)(OV300)(OV301), -Si(V302)(V303)(V304)"; where V253, V254, V255, V256, V257, V258, V259, V260, V261, V262, V263, V264, V265, V266, V267, V268, V269, V270, V271, V272, V273, 30 V274, V275, V276, V277, V278, V279, V280, V281, V282, V283, V284, V285, V286, V287, V288, V289, V290, V291, V292, V293, V294, V295, V296, V297, V298, V299, V300, V301, V302, V303, V304 are each independently selected from the group consisting of: "alkyl, (Cg-C 3 o)alkyl, W02007/054556 PCT/EP2006/068322 -328 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V259, V260 and/or V268, V269 and/or V281, V282 and/or V288, V289 and/or V297, V298 together may also form "heterocyclyl"; 5 where, optionally, additionally one of the Z3, Z4 radicals or additionally both Z3, Z4 radicals may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (d) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, 10 CF 3 , N 3 , NH 2 , -NHV305, -NV306V307, -NO 2 , -OH, -OCF 3 , -SH, -0 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-V308, -C(O)O-V309, -C(O)NH-V31 0, -C(O)NV31 1 V312, -O-V313, -O(-V314-O),-H (v = 1, 2, 3, 4, 5), -O(-V315-0),-V316 (v = 1, 2, 3, 4, 5), -OC(O)-V317, -OC(O)-O-V318, -OC(O)-NHV319, -0-C(O) 15 NV320V321, -OP(O)(OV322)(OV323), -OSi(V324)(V325)(V326), -OS(O 2 ) V327, -NHC(O)-V328, -NV329C(O)-V330, -NH-C(O)-O-V331, -NH C(O)-NH-V332, -NH-C(O)-NV333V334, -NV335-C(O)-O-V336, NV337-C(O)-NH-V338, -NV339-C(O)-NV340V341, -NHS(0 2 )-V342, NV343S(0 2 )-V344, -S-V345, -S(O)-V346, -S(0 2 )-V347, -S(0 2 )NH 20 V348, -S(0 2 )NV349V350, -S(0 2 )O-V351, -P(O)(OV352)(OV353), Si(V354)(V355)(V356)"; where V305, V306, V307, V308, V309, V310, V311, V312, V313, V314, V315, V316, V317, V318, V319, V320, V321, V322, V323, V324, V325, V326, V327, V328, V329, V330, V331, V332, V333, V334, V335, V336, 25 V337, V338, V339, V340, V341, V342, V343, V344, V345, V346, V347, V348, V349, V350, V351, V352, V353, V354, V355, V356 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V311, V312 and/or 30 V320, V321 and/or V333, V334 and/or V340, V341 and/or V349, V350 together may also form "heterocyclyl"; W02007/054556 -329- PCT/EP20061068322 where, optionally, the above substituents of substituent group (d) may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHV357, -NV358V359, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V360, -C(O)O-V361, -C(O)NH-V362, C(O)NV363V364, -O-V365, -O(-V366-0).-H (w = 1, 2, 3, 4, 5), -O( 10 V367-0),-V368 (w = 1, 2, 3, 4, 5), -OC(O)-V369, -OC(O)-O-V370, OC(O)-NHV371, -0-C(O)-NV372V373, -OP(O)(OV374)(OV375), OSi(V376)(V377)(V378), -OS(0 2 )-V379, -NHC(O)-V380, NV381 C(O)-V382, -N H-C(O)-O-V383, -N H-C(O)-N H-V384, -NH C(O)-NV385V386, -NV387-C(O)-O-V388, -NV389-C(O)-NH-V390, 15 -NV391-C(O)-NV392V393, -NHS(0 2 )-V394, -NV395S(0 2 )-V396, -S V397, -S(O)-V398, -S(0 2 )-V399, -S(0 2 )NH-V400, -S(O 2 )NV401V402, -S(0 2 )O-V403, -P(O)(OV404)(OV405), -Si(V406)(V407)(V408)"; where V357, V358, V359, V360, V361, V362, V363, V364, V365, V366, V367, V368, V369, V370, V371, V372, V373, V374, V375, V376, V377, 20 V378, V379, V380, V381, V382, V383, V384, V385, V386, V387, V388, V389, V390, V391, V392, V393, V394, V395, V396, V397, V398, V399, V400, V401, V402, V403, V404, V405, V406, V407, V408 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 25 heteroaryl, heteroarylalkyl" and where, alternatively, V363, V364 and/or V372, V373 and/or V385, V386 and/or V392, V393 and/or V401, V402 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) and/or substituent group (ii) may each independently in turn be substituted by at 30 least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, W02007/054556 -330- PCT/EP2006/068322 CN, CF 3 , N 3 , NH 2 , -NHV409, -NV41OV411, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V412, -C(O)O-V413, -C(O)NH-V414, C(O)NV415V416, -O-V417, -O(-V418-O).-H (x = 1, 2, 3, 4, 5), -O( 5 V419-0).-V420 (x = 1, 2, 3, 4, 5), -OC(O)-V421, -OC(O)-O-V422, OC(O)-NHV423, -0-C(O)-NV424V425, -OP(O)(OV426)(OV427), OSi(V428)(V429)(V430), -OS(0 2 )-V431, -NHC(O)-V432, NV433C(O)-V434, -NH-C(O)-O-V435, -NH-C(O)-NH-V436, -NH C(O)-NV437V438, -NV439-C(O)-O-V440, -NV441-C(O)-NH-V442, 10 -NV443-C(O)-NV444V445, -NHS(0 2 )-V446, -NV447S(0 2 )-V448, -S V449, -S(O)-V450, -S(0 2 )-V451, -S(0 2 )NH-V452, -S(0 2 )NV453V454, -S(0 2 )O-V455, -P(O)(OV456a)(OV456b), -Si(V456c)(V456d)(V456e)"; where V409, V410, V411, V412, V413, V414, V415, V416, V417, V418, V419, V420, V421, V422, V423, V424, V425, V426, V427, V428, V429, 15 V430, V431, V432, V433, V434, V435, V436, V437, V438, V439, V440, V441, V442, V443, V444, V445, V446, V447, V448, V449, V450, V451, V452, V453, V454, V455, V456a, V456b, V456c, V456d, V456e are each independently selected from the group consisting of: "alkyl, (C C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 20 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V415, V416 and/or V424, V425 and/or V437, V438 and/or V444, V445 and/or V453, V454 together may also form "heterocyclyl"; and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently 25 selected from the group consisting of: (e) hydrogen; (f) halogen, F, Cl, Br, I; (g) unsubstituted or substituted alkyl or (Cg-C 30 )alkyl, where, optionally, the alkyl or (C 9 -C 30 )alkyl radical may be substituted by at least one substituent 30 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV457, -NV458V459, -NO 2 , -OH, -OCF 3 , -SH, W02007/054556 -331- PCT/EP2006/068322 -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH)2, -C(O)-V460, -C(O)O-V461, -C(O)NH-V462, C(O)NV463V464, -O-V465, -O(-V466-O)-H (y = 1, 2, 3, 4, 5), -O( V467-O)rV468 (y = 1, 2, 3, 4, 5), -OC(O)-V469, -OC(O)-O-V470, 5 OC(O)-NHV471, -O-C(O)-NV472V473, -OP(O)(OV474)(OV475), OSi(V476)(V477)(V478), -OS(0 2 )-V479, -NHC(O)-V480, NV481C(O)-V482, -NH-C(O)-O-V483, -NH-C(O)-NH-V484, -NH C(O)-NV485V486, -NV487-C(O)-O-V488, -NV489-C(O)-NH V490, -NV491-C(O)-NV492V493, -NHS(0 2 )-V494, -NV495S(0 2 ) 10 V496, -S-V497, -S(O)-V498, -S(0 2 )-V499, -S(0 2 )NH-V500, S(0 2 )NV501V502, -S(0 2 )O-V503, -P(O)(OV504)(OV505), Si(V506)(V507)(V508)"; where V457, V458, V459, V460, V461, V462, V463, V464, V465, V466, V467, V468, V469, V470, V471, V472, V473, V474, V475, 15 V476, V477, V478, V479, V480, V481, V482, V483, V484, V485, V486, V487, V488, V489, V490, V491, V492, V493, V494, V495, V496, V497, V498, V499, V500, V501, V502, V503, V504, V505, V506, V507, V508 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, 20 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V463, V464 and/or V472, V473 and/or V485, V486 and/or V492, V493 and/or V501, V502, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 25 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV509, -NV51OV511, -N0 2 , -OH, 30 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V512, -C(O)O-V513, -C(O)NH V514, -C(O)NV515V516, -O-V517, -O(-V5118-0),-H (z = 1, 2, 3, 4, 5), -O(-V519-O)-V520 (z = 1, 2, 3, 4, 5), -OC(O)-V521, OC(O)-O-V522, -OC(O)-NHV523, -0-C(O)-NV524V525, - W02007/054556 PCT/EP2006/068322 - 332 OP(O)(OV526)(OV527), -OSi(V528)(V529)(V530), -OS(0 2 ) V531, -NHC(O)-V532, -NV533C(O)-V534, -NH-C(O)-O-V535, -NH-C(O)-NH-V536, -NH-C(O)-NV537V538, -NV539-C(O)-O V540, -NV541-C(O)-NH-V542, -NV543-C(O)-NV544V545, 5 NHS(0 2 )-V546, -NV547S(0 2 )-V548, -S-V549, -S(O)-V550, S(0 2 )-V551, -S(0 2 )NH-V552, -S(0 2 )NV553V554, -S(0 2 )O V555, -P(O)(OV556)(OV557), -Si(V558)(V559)(V560)"; where V509, V510, V511, V512, V513, V514, V515, V516, V517, V518, V519, V520, V521, V522, V523, V524, V525, V526, V527, 10 V528, V529, V530, V531, V532, V533, V534, V535, V536, V537, V538, V539, V540, V541, V542, V543, V544, V545, V546, V547, V548, V549, V550, V551, V552, V553, V554, V555, V556, V557, V558, V559, V560 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 15 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V515, V516 and/or V524, V525 and/or V537, V538 and/or V544, V545 and/or V553, V554, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) 20 may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 25 Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHV561, -NV562V563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V564, -C(O)O-V565, C(O)NH-V566, -C(O)NV567V568, -O-V569, -O(-V570-O)a H (a = 1, 2, 3, 4, 5), -0(-V571-0)a-V572 (a = 1, 2, 3, 4, 5), 30 OC(O)-V573, -OC(O)-O-V574, -OC(O)-NHV575, -0-C(O) NV576V577, -OP(O)(OV578)(OV579), OSi(V580)(V581)(V582), -OS(0 2 )-V583, -NHC(O)-V584, NV585C(O)-V586, -NH-C(O)-O-V587, -NH-C(O)-NH V588, -NH-C(O)-NV589V590, -NV591-C(O)-O-V592, - W02007/054556 -333- PCT/EP2006/068322 NV593-C(O)-NH-V594, -NV595-C(O)-NV596V597, NHS(0 2 )-V598, -NV599S(0 2 )-V600, -S-V601, -S(O)-V602, -S(0 2 )-V603, -S(0 2 )NH-V604, -S(0 2 )NV605V606, -S(0 2 )O V607, -P(O)(OV608)(OV609), -Si(V61 0)(V61 1)(V612)"; 5 where V561, V562, V563, V564, V565, V566, V567, V568, V569, V570, V571, V572, V573, V574, V575, V576, V577, V578, V579, V580, V581, V582, V583, V584, V585, V586, V587, V588, V589, V590, V591, V592, V593, V594, V595, V596, V597, V598, V599, V600, V601, V602, V603, V604, 10 V605, V606, V607, V608, V609, V610, V611, V612 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V567, V568 and/or V576, V577 and/or 15 V589, V590 and/or V596, V597 and/or V605, V606, in each case together, may also form "heterocyclyl"; (h) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently 20 from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV613, -NV614V615, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 25 P(O)(OH) 2 , -C(O)-V616, -C(O)O-V617, -C(O)NH-V618, C(O)NV619V620, -O-V621, -O(-V622-O)b-H (b = 1, 2, 3, 4, 5), -O( V623-O)b-V62 4 (b = 1, 2, 3, 4, 5), -OC(O)-V625, -OC(O)-O-V626, OC(O)-NHV627, -0-C(O)-NV628V629, -OP(O)(OV630)(OV631), OSi(V632)(V633)(V634), -OS(O 2 )-V635, -NHC(O)-V636, 30 NV637C(O)-V638, -NH-C(O)-O-V639, -NH-C(O)-NH-V640, -NH C(O)-NV641V642, -NV643-C(O)-O-V644, -NV645-C(O)-NH V646, -NV647-C(O)-NV648V649, -NHS(0 2 )-V650, -NV651S(02) V652, -S-V653, -S(O)-V654, -S(0 2 )-V655, -S(0 2 )NH-V656, - W02007/054556 -334- PCT/EP2006/068322 S(0 2 )NV657V658, -S(0 2 )O-V659, -P(O)(OV660)(OV661), Si(V662)(V663)(V664)"; where V613, V614, V615, V616, V617, V618, V619, V620, V621, V622, V623, V624, V625, V626, V627, V628, V629, V630, V631, 5 V632, V633, V634, V635, V636, V637, V638, V639, V640, V641, V642, V643, V644, V645, V646, V647, V648, V649, V650, V651, V652, V653, V654, V655, V656, V657, V658, V659, V660, V661, V662, V663, V664 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 10 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V619, V620 and/or V628, V629 and/or V641, V642 and/or V648, V649 and/or V657, V658, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 15 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV665, -NV666V667, -NO 2 , -OH, 20 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH)2, -C(O)-V668, -C(O)O-V669, -C(O)NH V670, -C(O)NV671V672, -O-V673, -O(-V674-O)c-H (c = 1, 2, 3, 4, 5), -O(-V675-O)c-V676 (c = 1, 2, 3, 4, 5), -OC(O)-V677, OC(O)-O-V678, -OC(O)-NHV679, -O-C(O)-NV680V681, 25 OP(O)(OV682)(OV683), -OSi(V684)(V685)(V686), -OS(0 2 ) V687, -NHC(O)-V688, -NV689C(O)-V690, -NH-C(O)-O-V691, -N H-C(O)-N H-V692, -NH-C(O)-NV693V694, -NV695-C(O)-O V696, -NV697-C(O)-NH-V698, -NV699-C(O)-NV700V701, NHS(0 2 )-V702, -NV703S(0 2 )-V704, -S-V705, -S(O)-V706, 30 S(0 2 )-V707, -S(0 2 )NH-V708, -S(0 2 )NV709V710, -S(0 2 )O V71 1, -P(O)(OV712)(OV713), -Si(V714)(V715)(V716)"; where V665, V666, V667, V668, V669, V670, V671, V672, V673, V674, V675, V676, V677, V678, V679, V680, V681, V682, V683, W02007/054556 -335- PCTIEP2006/068322 V684, V685, V686, V687, V688, V689, V690, V691, V692, V693, V694, V695, V696, V697, V698, V699, V700, V701, V702, V703, V704, V705, V706, V707, V708, V709, V710, V711, V712, V713, V714, V715, V716 are each independently selected from the group 5 consisting of: "alkyl, (C9-C 3 o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V671, V672 and/or V680, V681 and/or V693, V694 and/or V700, V701 and/or V709, V710, in each case together, may also form "heterocyclyl"; 10 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV717, -NV718V719, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V720, -C(O)O-V721, C(O)NH-V722, -C(O)NV723V724, -O-V725, -O(-V726-O)d 20 H (d = 1, 2, 3, 4, 5), -O(-V727-O)d-V 728 (d = 1, 2, 3, 4, 5), OC(O)-V729, -OC(O)-O-V730, -OC(O)-NHV731, -O-C(O) NV732V733, -OP(O)(OV734)(OV735), OSi(V736)(V737)(V738), -OS(0 2 )-V739, -NHC(O)-V740, NV741C(O)-V742, -NH-C(O)-O-V743, -NH-C(O)-NH 25 V744, -NH-C(O)-NV745V746, -NV747-C(O)-O-V748, NV749-C(O)-NH-V750, -NV751-C(O)-NV752V753, NHS(0 2 )-V754, -NV755S(0 2 )-V756, -S-V757, -S(O)-V758, -S(0 2 )-V759, -S(0 2 )NH-V760, -S(0 2 )NV761V762, -S(0 2 )O V763, -P(O)(OV764)(OV765), -Si(V766)(V767)(V768)"; 30 where V717, V718, V719, V720, V721, V722, V723, V724, V725, V726, V727, V728, V729, V730, V731, V732, V733, V734, V735, V736, V737, V738, V739, V740, V741, V742, V743, V744, V745, V746, V747, V748, V749, V750, V751, V752, V753, V754, V755, V756, V757, V758, V759, V760, W020071054556 PCT/EP20061068322 -336 V761, V762, V763, V764, V765, V766, V767, V768 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 5 where, alternatively, V723, V724 and/or V732, V733 and/or V745, V746 and/or V752, V753 and/or V761, V762, in each case together, may also form "heterocyclyl"; (j) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl 10 radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, C1, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV769, -NV770V771, -NO 2 , -OH, -OCF 3 , -SH, 15 -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-V772, -C(O)O-V773, -C(O)NH-V774, C(O)NV775V776, -0-V777, -0(-V778-O)e-H (e = 1, 2, 3, 4, 5), -O( V779-O)e-V780 (e = 1, 2, 3, 4, 5), -OC(O)-V781, -OC(O)-O-V782, OC(O)-NHV783, -0-C(O)-NV784V785, -OP(O)(OV786)(OV787), 20 OSi(V788)(V789)(V790), -OS(0 2 )-V791, -NHC(O)-V792, NV793C(O)-V794, -NH-C(O)-O-V795, -NH-C(O)-NH-V796, -NH C(O)-NV797V798, -NV799-C(O)-O-V800, -NV801-C(O)-NH V802, -NV803-C(O)-NV804V805, -NHS(0 2 )-V806, -NV807S(0 2 ) V808, -S-V809, -S(O)-V810, -S(0 2 )-V811, -S(0 2 )NH-V812, 25 S(0 2 )NV813V814, -S(0 2 )O-V815, -P(O)(OV816)(OV817), Si(V818)(V819)(V820)"; where V769, V770, V771, V772, V773, V774, V775, V776, V777, V778, V779, V780, V781, V782, V783, V784, V785, V786, V787, V788, V789, V790, V791, V792, V793, V794, V795, V796, V797, 30 V798, V799, V800, V801, V802, V803, V804, V805, V806, V807, V808, V809, V810, V811, V812, V813, V814, V815, V816, V817, V818, V819, V820 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, W02007/054556 PCT/EP2006/068322 - 337 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V775, V776 and/or V784, V785 and/or V797, V798 and/or V804, V805 and/or V813, V814, in each case together, may also form "heterocyclyl"; 5 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 10 Br, 1, CN, CF 3 , N 3 , NH 2 , -NHV821, -NV822V823, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V824, -C(O)O-V825, -C(O)NH V826, -C(O)NV827V828, -0-V829, -O(-V830-0)r-H (f = 1, 2, 3, 4, 5), -O(-V831-)r-V832 (f = 1, 2, 3, 4, 5), -OC(O)-V833, 15 OC(O)-O-V834, -OC(O)-NHV835, -0-C(O)-NV836V837, OP(O)(OV838)(OV839), -OSi(V840)(V841)(V842), -OS(0 2 ) V843, -NHC(O)-V844, -NV845C(O)-V846, -NH-C(O)-O-V847, -NH-C(O)-NH-V848, -NH-C(O)-NV849V850, -NV851-C(O)-O V852, -NV853-C(O)-NH-V854, -NV855-C(O)-NV856V857, 20 NHS(0 2 )-V858, -NV859S(0 2 )-V860, -S-V861, -S(O)-V862, S(0 2 )-V863, -S(0 2 )NH-V864, -S(0 2 )NV865V866, -S(0 2 )O V867, -P(O)(OV868)(OV869), -Si(V870)(V871)(V872)"; where V821, V822, V823, V824, V825, V826, V827, V828, V829, V830, V831, V832, V833, V834, V835, V836, V837, V838, V839, 25 V840, V841, V842, V843, V844, V845, V846, V847, V848, V849, V850, V851, V852, V853, V854, V855, V856, V857, V858, V859, V860, V861, V862, V863, V864, V865, V866, V867, V868, V869, V870, V871, V872 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 30 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V827, V828 and/or V836, V837 and/or V849, V850 and/or V856, V857 and/or V865, V866, in each case together, may also form "heterocyclyl"; W02007/054556 -338- PCT/EP2006/068322 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (Cg-C3o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV873, -NV874V875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V876, -C(O)O-V877, 10 C(O)NH-V878, -C(O)NV879V880, -O-V881, -O(-V882-O)g H (g = 1, 2, 3, 4, 5), -0(-V883-0)g-V884 (g = 1, 2, 3, 4, 5), OC(O)-V885, -OC(O)-O-V886, -OC(O)-NHV887, -0-C(O) NV888V889, -OP(O)(OV890)(OV891), OSi(V892)(V893)(V894), -OS(0 2 )-V895, -NHC(O)-V896, 15 NV897C(O)-V898, -NH-C(O)-O-V899, -NH-C(O)-NH V900, -NH-C(O)-NV901V902, -NV903-C(O)-0-V904, NV905-C(O)-NH-V906, -NV907-C(O)-NV908V909, NHS(0 2 )-V91 0, -NV91 1 S(0 2 )-V912, -S-V913, -S(O)-V914, -S(O 2 )-V915, -S(0 2 )NH-V916, -S(0 2 )NV917V918, -S(0 2 )O 20 V919, -P(O)(OV920)(OV921), -Si(V922)(V923)(V924)"; where V873, V874, V875, V876, V877, V878, V879, V880, V881, V882, V883, V884, V885, V886, V887, V888, V889, V890, V891, V892, V893, V894, V895, V896, V897, V898, V899, V900, V901, V902, V903, V904, V905, V906, V907, 25 V90 8 ,V909,V910,V911,V912,V913,V914,V915,V916, V917, V918, V919, V920, V921, V922, V923, V924 are each independently selected from the group consisting of: "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 30 where, alternatively, V879, V880 and/or V888, V889 and/or V901, V902 and/or V908, V909 and/or V917, V918, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -339 (k) OZ6 where Z6 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 5 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV925, -NV926V927, -NO 2 , -OH, 10 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V928, -C(O)O-V929, -C(O)NH V930, -C(O)NV931V932, -O-V933, -0(-V934-O)h-H (h = 1, 2, 3, 4, 5), -O(-V935-O)h-V936 (h = 1, 2, 3, 4, 5), -OC(O)-V937, OC(O)-O-V938, -OC(O)-NHV939, -0-C(O)-NV940V941, 15 OP(O)(OV942)(OV943), -OSi(V944)(V945)(V946), -OS(0 2 ) V947, -NHC(O)-V948, -NV949C(O)-V950, -NH-C(O)-O-V951, -NH-C(O)-NH-V952, -NH-C(O)-NV953V954, -NV955-C(O)-O V956, -NV957-C(O)-NH-V958, -NV959-C(O)-NV960V961, NHS(0 2 )-V962, -NV963S(0 2 )-V964, -S-V965, -S(O)-V966, 20 S(0 2 )-V967, -S(0 2 )NH-V968, -S(0 2 )NV969V970, -S(0 2 )O V971, -P(O)(OV972)(OV973), -Si(V974)(V975)(V976)"; where V925, V926, V927, V928, V929, V930, V931, V932, V933, V934, V935, V936, V937, V938, V939, V940, V941, V942, V943, V944, V945, V946, V947, V948, V949, V950, V951, V952, V953, 25 V954, V955, V956, V957, V958, V959, V960, V961, V962, V963, V964, V965, V966, V967, V968, V969, V970, V971, V972, V973, V974, V975, V976 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 30 heteroarylalkyl" and where, alternatively, V931, V932 and/or V940, V941 and/or V953, V954 and/or V960, V961 and/or V969, V970, in each case together, may also form "heterocyclyl"; W02007/054556 -340- PCT/EP2006/068322 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV977, -NV978V979, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V980, -C(O)O-V981, 10 C(O)NH-V982, -C(O)NV983V984, -O-V985, -O(-V986-O)r H (i = 1, 2, 3, 4, 5), -O(-V987-0)r-V98 8 (i = 1, 2, 3, 4, 5), OC(O)-V989, -OC(O)-O-V990, -OC(O)-NHV991, -0-C(0) NV992V993, -OP(O)(OV994)(OV995), OSi(V996)(V997)(V998), -OS(0 2 )-V999, -NHC(O)-V1000, 15 NV1 001 C(O)-V1 002, -NH-C(O)-0-V1 003, -NH-C(O)-NH V1004, -NH-C(O)-NV1005V1006, -NV1007-C(O)-O-V1008, -NV1009-C(O)-NH-V1010, -NV1011-C(O)-NV1012V1013, NHS(0 2 )-V1014, -NV1015S(0 2 )-V1016, -S-V1017, -S(O) V1018, -S(0 2 )-V1019, -S(0 2 )NH-V1020, 20 S(0 2 )NV1 021 V1 022, -S(0 2 )O-V1023, P(O)(OV1 024)(OV1 025), -Si(V1 026)(V1 027)(V1 028)"; where V977, V978, V979, V980, V981, V982, V983, V984, V985, V986, V987, V988, V989, V990, V991, V992, V993, V994, V995, V996, V997, V998, V999, V1000, V1001, V1002, 25 V1003, V1004, V1O5, V1006, V1007, V1008, V1009, V1OlO, V1011, V1012, V1013, V1014, V1015, V1016, V1017, V1018, V1019, V1020, V1021, V1022, V1023, V1024, V1025, V1026, V1 027, V1028 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 30 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V983, V984 and/or V992, V993 and/or V1005, V1006 and/or V1012, V1013 and/or V1021, V1022, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 341 (1) SZ7 where Z7 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; 5 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) alkyll, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 10 Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1029, -NV1030V1031, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1032, -C(O)O-V1033, C(O)NH-V1034, -C(O)NV1035V1 036, -O-V1 037, -O(-V1 038 O) 1 -H (j = 1, 2, 3, 4, 5), -O(-V1039-0)j-V1040 (j = 1, 2, 3, 4, 5), 15 OC(O)-V1041, -OC(O)-O-V1042, -OC(O)-NHV1043, -0-C(O) NV1 044V1 045, -OP(O)(OV1 046)(OV1 047), OSi(V1 048)(V1 049)(V1 050), -OS(0 2 )-V1 051, -NHC(O)-V1 052, NV1053C(O)-V1054, -NH-C(O)-O-V1055, -NH-C(O)-NH V1056, -NH-C(O)-NV1057V1058, -NV1059-C(O)-O-V1060, 20 NV1061-C(O)-NH-V1062, -NV1063-C(O)-NV1064V1065, NHS(0 2 )-V1066, -NV1067S(O 2 )-V1068, -S-V1069, -S(O) V1070, -S(0 2 )-V1071, -S(0 2 )NH-V1072, -S(0 2 )NV1073V1074, S(0 2 )O-V1075, -P(O)(OV1076)(OV1077), Si(V1 078)(V1 079)(V1 080)"; 25 where V1029, V1030, V1031, V1032, V1033, V1034, V1035, V1036, V1037, V1038, V1039, V1040, V1041, V1042, V1043, V1044, V1045, V1046, V1047, V1048, V1049, V1050, V1051, V1 052, V1 053, VI 054, V1 055, V1 056, VI 057, V1058, VI 059, V1060, V1061, V1062, V1063, V1064, V1065, V1066, V1067, 30 V1068, V1069, V1070, V1071, V1072, V1073, V1074, V1075, V1076, V1 077, V1 078, V1 079, V1080 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, W02007/054556 -342- PCT/EP2006/068322 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1035, V1036 and/or V1044, V1045 and/or V1057, V1058 and/or V1 064, V1065 and/or V1073, V1074, in each case together, may also form "heterocyclyl"; 5 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1081, -NV1082V1083, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1084, -C(0)0 V1085, -C(O)NH-V1086, -C(O)NV1087V1088, -O-V1089, 15 O(-V1090-O)k-H (k = 1, 2, 3, 4, 5), -O(-V1091-O)k-V1092 (k = 1, 2, 3, 4, 5), -OC(O)-V1093, -OC(O)-O-V1 094, -OC(O) NHV1095, -0-C(O)-NV1096V1097, OP(O)(OV1098)(OV1099), -OSi(V1 100)(V1 101)(V1 102), OS(0 2 )-V1 103, -NHC(O)-V1 104, -NV1 105C(O)-V1 106, 20 NH-C(O)-O-V1 107, -NH-C(O)-NH-V 108, -NH-C(O) NV1109V1110, -NV1 111-C(O)-O-V111 2 , -NV1113-C(O) NH-V1114, -NV1115-C(O)-NV1116V1117, -NHS(0 2 ) V1118, -NV1119S(0 2 )-V1120, -S-V1121, -S(O)-V1122, S(0 2 )-V1 123, -S(0 2 )NH-V1 124, -S(0 2 )NV1 125V1 126, 25 S(0 2 )O-V1 127, -P(O)(OV 128)(OV1 129), Si(V1 130)(V1 131)(V1 132)"; where V1081, V1082, V1083, V1084, V1085, V1086, V1087, V1 088, V1 089, V1 090, V1 091, V1 092, V1 093, VI 094, V1 095, V1096, V1097, V1098, V1099, V1100, V1101, V1102, V1103, 30 V1104, V1105, V1106, V1107, V1108, V1109, V1110, V1111, V1112, V1113, V1114, V1115, V1116, V1117, V1118, V1119, V1120, V1121, V1122, V1123, V1124, V1125, V1126, V1127, V1128, V1129, V1130, V1131, V1132 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, W02007/054556 PCT/EP2006/068322 - 343 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1087, V1088 and/or V1096, V1097 and/or V1109, V1110 and/or V1116, V1117 and/or V1125, V1126, in each case 5 together, may also form "heterocyclyl"; (m) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) V1133, -C(O)O-V1134, -C(O)-NV1135V1136, -S(0 2 )-V1137, S(0 2 )O-V1 138"; where V1133, V1134, V1135, V1136, V1137, V1138 are each independently selected from the group consisting of: hydrogen, alkyl, 15 (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1 135, V1136 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 20 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHV1139, -NV1140V1 141, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 25 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1 142, -C(O)O-V1 143, C(O)NH-V1 144, -C(O)NV1 145V1 146, -0-V1 147, -O(-V1 148 O)[H (I = 1, 2, 3, 4, 5), -0(-V1 149-O)r-V1 150 (1 = 1, 2, 3, 4, 5), OC(O)-V1 151, -OC(O)-O-V1 152, -OC(O)-NHV1 153, -0-C(O) NV1 154V1 155, -OP(O)(OV1 156)(OV1 157), 30 OSi(V 158)(V1 159)(V1 160), -OS(0 2 )-V1 161, -NHC(O)-V1 162, NV1 163C(O)-V1 164, -NH-C(O)-O-V1 165, -NH-C(O)-NH V1 166, -NH-C(O)-NV1 167V1168, -NV1 169-C(O)-O-V1 170, NV1171-C(O)-NH-V1172, -NV1173-C(O)-NV1174V1175, - W02007/054556 -344- PCT/EP2006/068322 NHS(0 2 )-V1 176, -NV 177S(0 2 )-V1 178, -S-V1 179, -S(O) V1180, -S(0 2 )-V1181, -S(0 2 )NH-V1182, -S(0 2 )NV1183V1184, S(0 2 )O-V1 185, -P(O)(OV1 186)(OV1 187), Si(V1 188)(V1 189)(V1 190)"; 5 where V1139, V1140, V1141, V1142, V114 3 , V 1144 , V1145, V1146, V1147, V1148, V1149, V1l5O, V1151, V1152, V1153, V1154, V1155, V1156, V1157, V1158, V1159, V1160, V1161, V1162, V1163, V1164, V1165, V1166, V1167, V1168, V1169, V1170, V1171, V1172, V1173, V1174, V1175, V1176, V1177, 10 V1178, V1179, V1180, V1181, V1182, V1183, V1184, V1185, V1 186, V1i187, V1188, V1189, V1190 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 15 V1145, V1146 and/or V1154, V1155 and/or V1167, V1168 and/or V1i174, V1i175 and/or V1183, V1184, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 20 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHV1191, -NV1192V1193, -NO 2 , 25 -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-V1 194, -C(0)0 V1195, -C(O)NH-V1196, -C(O)NV1197V1198, -O-V1 199, O(-V1200-0)m-H (m = 1, 2, 3, 4, 5), -0(-V1201-0)m-V1202 (m = 1, 2, 3, 4, 5), -OC(O)-V1 203, -OC(O)-O-V1 204, 30 OC(O)-NHV1205, -O-C(O)-NV1206V1207, OP(O)(OV1 208)(OV1209), -OSi(V1210)(V1 21 1)(V1212), OS(0 2 )-V1 213, -NHC(O)-V1214, -NV1 215C(O)-V1 216, NH-C(O)-O-V1217, -NH-C(O)-NH-V1218, -NH-C(O) NV1219V1220, -NV1221-C(O)-O-V122 2 , -NV1223-C(O)- W02007/054556 -345- PCT/EP2006/068322 NH-V1 224, -NV1 225-C(O)-NV1 226V1 227, -NHS(0 2 ) V1228, -NV1229S(0 2 )-V1230, -S-V1231, -S(O)-V1232, S(0 2 )-V1233, -S(0 2 )NH-V1234, -S(0 2 )NV1235V1236, S(0 2 )O-V1237, -P(O)(OV1238)(OV1239), 5 Si(V1240)(V1241)(V1242)"; where V1191, V1192, V1193, V1194, V1195, V1196, V1197, V1198, V1199, V1200, V1201, V1202, V1203, V1204, V1205, V1206, V1207, V1208, V1209, V121O, V1211, V1212, V1213, V1214, V1215, V1216, V1217, V1218, V1219, V1220, V1221, 10 V1222, V1223, V1224, V1225, V1226, V1227, V1228, V1229, V1230, V1231, V1232, V1233, V1234, V1235, V1236, V1237, V1238, V1239, V1240, V1241, V1242 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 15 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, V1 197, V1 198 and/or V1206, V1207 and/or V1219, V1220 and/or V1226, V1227 and/or V1235, V1236, in each case together, may also form "heterocyclyl"; 20 or (C) one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "substituted alkyl", where "substituted alkyl" is substituted by at least one substituent selected from the group consisting of: 25 (a) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1, -NW2W3, -NO 2 , -OH, -OCF 3 , -SH, -0 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-W4, -C(O)O-W5, -C(O)NH-W6, -C(O)NW7W8, -O-W9, -0( 30 W1O-O)rH (r = 1, 2, 3, 4, 5), -O(-W11-O)r-W1 2 (r = 1, 2, 3, 4, 5), OC(O)-W13, -OC(O)-O-W14, -OC(O)-NHW15, -O-C(O)-NW16W17, OP(O)(OW1 8)(OW19), -OSi(W20)(W21)(W22), -OS(0 2 )-W23, NHC(O)-W24, -NW25C(O)-W26, -NH-C(O)-O-W27, -N H-C(O)-N H- W02007/054556 PCT/EP2006/068322 - 346 W28, -NH-C(O)-NW29W30, -NW31-C(O)-O-W32, -NW33-C(O)-NH W34, -NW35-C(O)-NW36W37, -NHS(0 2 )-W38, -NW39S(0 2 )-W40, S-W41, -S(O)-W42, -S(0 2 )-W43, -S(0 2 )NH-W44, -S(0 2 )NW45W46, S(0 2 )O-W47, -P(O)(OW48)(OW49), -Si(W50)(W51)(W52)"; 5 where W1, W2, W3, W4, W5, W6, W7, W8, W9, W10, W11, W12, W13, W14, W15, W16, W17, W18, W19, W20, W21, W22, W23, W24, W25, W26, W27, W28, W29, W30, W31, W32, W33, W34, W35, W36, W37, W38, W39, W40, W41, W42, W43, W44, W45, W46, W47, W48, W49, W50, W51, W52 are each independently selected from the group 10 consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W7, W8 and/or W16, W17 and/or W29, W30 and/or W36, W37 and/or W45, W46, in each case together, may also form "heterocyclyl"; 15 with the proviso that "-C(O)NH-aryl", "-C(O)NH-heteroaryl", "-C(O)NH cycloalkyl", "-C(O)NH-heterocyclyl" are substituted further by at least one substituent selected from the following substitution group (i); where, optionally, the above substituents of substituent group (a) may in turn each independently be substituted by at least one substituent 20 selected identically or differently from the group consisting of: (i) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW53, -NW54W55, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 25 P(O)(OH) 2 , -C(O)-W56, -C(O)O-W57, -C(O)NH-W58, C(O)NW59W60, -O-W61, -O(-W62-0),-H (s = 1, 2, 3, 4, 5), -O( W63-O)t-W64 (t = 1, 2, 3, 4, 5), -OC(O)-W65, -OC(O)-O-W66, OC(O)-NHW67, -0-C(O)-NW68W69, -OP(O)(OW70)(OW71), OSi(W72)(W73)(W74), -OS(0 2 )-W75, -NHC(O)-W76, -NW77C(O) 30 W78, -NH-C(O)-O-W79, -NH-C(O)-NH-W80, -NH-C(O) NW81W82, -NW83-C(O)-O-W84, -NW85-C(O)-NH-W86, -NW87 C(O)-NW88W89, -NHS(0 2 )-W90, -NW91S(0 2 )-W92, -S-W93, - W02007/054556 PCT/EP2006/068322 - 347 S(O)-W94, -S(0 2 )-W95, -S(0 2 )NH-W96, -S(0 2 )NW97W98, S(0 2 )O-W99, -P(O)(OW100)(OW101), -Si(W102)(W103)(W104)"; where W53, W54, W55, W56, W57, W58, W59, W60, W61, W62, W63, W64, W65, W66, W67, W68, W69, W70, W71, W72, W73, W74, 5 W75, W76, W77, W78, W79, W80, W81, W82, W83, W84, W85, W86, W87, W88, W89, W90, W91, W92, W93, W94, W95, W96, W97, W98, W99, W100, W101, W102, W103, W104 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 10 heteroaryl, heteroarylalkyl" and where, alternatively, W59, W60 and/or W68, W69 and/or W81, W82 and/or W88, W89 and/or W97, W98, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 15 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW105, -NW106W107, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 20 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W108, -C(O)O-W109, -C(O)NH-W1 10, -C(0)NW1 11W112, -O-W1 13, -O(-W1 14 O)t-H (t = 1, 2, 3, 4, 5), -O(-W115-O)t-W116 (t = 1, 2, 3, 4, 5), -OC(O)-Wi 17, -OC(O)-O-W1 18, -OC(O)-NHW1 19, -0 C(O)-NW12OW121, -OP(O)(OW122)(OW123), 25 OSi(W124)(W125)(W126), -OS(0 2 )-W127, -NHC(O)-W128, -NW1 29C(O)-W130, -NH-C(O)-O-W131, -NH-C(O)-NH W132, -NH-C(O)-NW1 33W134, -NW1 35-C(O)-O-W136, NW1 37-C(O)-NH-W138, -NW1 39-C(O)-NW140W141, NHS(0 2 )-W142, -NW143S(0 2 )-W144, -S-W145, -S(O) 30 W146, -S(0 2 )-W 147, -S(0 2 )NH-W148, -S(0 2 )NW149W 150, -S(0 2 )O-W151, -P(O)(OW152)(OW153), Si(W154)(W155)(W156)"; W02007/054556 PCT/EP2006/068322 - 348 where W105, W106, W107, W108, W109, W110, W111, W112, W113, W114, W115, W116, W117, W118, W119, W120, W121, W122, W123, W124, W125, W126, W127, W128, W129, W130, W131, W132, W133, W134, W135, 5 W136, W137, W138, W139, W140, W141, W142, W143, W144, W145, W146, W147, W148, W149, W150, W151, W152, W153, W154, W155, W156 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 10 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W111, W112 and/or W120, W121 and/or W133, W134 and/or W140, W141 and/or W149, W150, in each case together, may also form "heterocyclyl"; 15 or one of the Z3, Z4 radicals is, or both Z3, Z4 radicals are, independently "(Cg C 3 0 )alkyl"; where "(C 9 -C 30 )alkyl" may independently optionally be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW157, -NW158W159, -NO 2 , -OH, -OCF 3 , -SH, -0 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-W160, -C(O)O-W161, -C(O)NH-W162, -C(O)NW163W164, -0 W165, -O(-W166-O),-H (u = 1, 2, 3, 4, 5), -O(-W167-0),-W168 (u = 1, 25 2, 3, 4, 5), -OC(O)-W169, -OC(O)-O-W170, -OC(O)-NHW171, -0 C(O)-NW1 72W173, -OP(O)(OW 1 74)(OW175), -OSi(W1 76)(W1 77)(W178), -OS(O 2 )-W179, -NHC(O)-W180, -NW181C(O)-W182, -NH-C(O)-O W183, -NH-C(O)-NH-W184, -NH-C(O)-NW1 85W 186, -NW1 87-C(O) O-W188, -NW1 89-C(O)-NH-W190, -NW191-C(O)-NW1 92W193, 30 NHS(0 2 )-W194, -NW195S(0 2 )-W196, -S-W197, -S(O)-W198, -S(02) W199, -S(0 2 )N H-W200, -S(0 2 )NW201 W202, -S(0 2 )O-W203, P(O)(OW204)(OW205), -Si(W206)(W207)(W208)"; W02007/054556 -349- PCT/EP2006/068322 where W157, W158, W159, W160, W161, W162, W163, W164, W165, W166, W167, W168, W169, W170, W171, W172, W173, W174, W175, W176, W177, W178, W179, W180, W181, W182, W183, W184, W185, W186, W187, W188, W189, W190, W191, W192, W193, W194, W195, 5 W196, W197, W198, W199, W200, W201, W202, W203, W204, W205, W206, W207, W208 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W163, W164 and/or W172, W173 and/or W185, W186 and/or 10 W192, W193 and/or W201, W202, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW209, -NW21OW211, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W212, -C(O)O-W213, -C(O)NH-W214, 20 C(O)NW215W216, -O-W217, -O(-W218-O),-H (v = 1, 2, 3, 4, 5), O(-W219-0),-W220 (v = 1, 2, 3, 4, 5), -OC(O)-W221, -OC(O)-O W222, -OC(O)-NHW223, -O-C(O)-NW224W225, OP(O)(OW226)(OW227), -OSi(W228)(W229)(W230), -OS(0 2 )-W231, -NHC(O)-W232, -NW233C(O)-W234, -NH-C(O)-O-W235, -NH 25 C(O)-NH-W236, -NH-C(O)-NW237W238, -NW239-C(O)-O-W240, NW241-C(O)-NH-W242, -NW243-C(O)-NW244W245, -NHS(0 2 ) W246, -NW247S(0 2 )-W248, -S-W249, -S(O)-W250, -S(0 2 )-W251, S(0 2 )NH-W252, -S(0 2 )NW253W254, -S(0 2 )O-W255, P(O)(OW256)(OW257), -Si(W258)(W259)(W260)"; 30 where W209, W210, W211, W212, W213, W214, W215, W216, W217, W218, W219, W220, W221, W222, W223, W224, W225, W226, W227, W228, W229, W230, W231, W232, W233, W234, W235, W236, W237, W238, W239, W240, W241, W242, W243, W244, W245, W246, W247, W248, W249, W250, W251, W252, W253, W254, W255, W256, W257, W02007/054556 -350- PCT/EP2006/068322 W258, W259, W260 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W215, W216 and/or W224, W225 and/or 5 W237, W238 and/or W244, W245 and/or W253, W254, in each case together, may also form "heterocyclyl"; and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently selected from the group consisting of: 10 (b) hydrogen; (c) halogen, F, Cl, Br, 1; (d) unsubstituted or substituted alkyl or (C 9 -C 30 )alkyl, where, optionally, the alkyl or (C 9 -C 30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW457, -NW458W459, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W460, -C(O)O-W461, -C(O)NH-W462, 20 C(O)NW463W464, -0-W465, -O(-W466-O)X-H (x = 1, 2, 3, 4, 5), O(-W467-O)x-W468 (x = 1, 2, 3, 4, 5), -OC(O)-W469, -OC(O)-O W470, -OC(O)-NHW471, -0-C(O)-NW472W473, OP(O)(OW474)(OW475), -OSi(W476)(W477)(W478), -OS(0 2 ) W479, -NHC(O)-W480, -NW481C(O)-W482, -NH-C(O)-O-W483, 25 NH-C(O)-NH-W484, -NH-C(O)-NW485W486, -NW487-C(O)-O W488, -NW489-C(O)-NH-W490, -NW491-C(O)-NW492W493, NHS(0 2 )-W494, -NW495S(0 2 )-W496, -S-W497, -S(O)-W498, S(0 2 )-W499, -S(0 2 )NH-W500, -S(0 2 )NW501W502, -S(0 2 )O-W503, -P(O)(OW504)(OW505), -Si(W506)(W507)(W508)"; 30 where W457, W458, W459, W460, W461, W462, W463, W464, W465, W466, W467, W468, W469, W470, W471, W472, W473, W474, W475, W476, W477, W478, W479, W480, W481, W482, W483, W484, W485, W486, W487, W488, W489, W490, W491, W492, W02007/054556 PCT/EP2006/068322 - 351 W493, W494, W495, W496, W497, W498, W499, W500, W501, W502, W503, W504, W505, W506, W507, W508 are each independently selected from the group consisting of: "alkyl, (C9 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 5 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W463, W464 and/or W472, W473 and/or W485, W486 and/or W492, W493 and/or W501, W502, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 10 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW509, -NW51OW511, -NO 2 , -OH, 15 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W512, -C(O)O-W513, -C(O)NH W514, -C(O)NW515W516, -O-W517, -O(-W518-O)y-H (y = 1, 2, 3, 4, 5), -O(-W519-O)y-W520 (y = 1, 2, 3, 4, 5), -OC(O) W521, -OC(O)-O-W522, -OC(O)-NHW523, -0-C(O) 20 NW524W525, -OP(O)(OW526)(OW527), OSi(W528)(W529)(W530), -OS(0 2 )-W531, -NHC(O)-W532, NW533C(O)-W534, -NH-C(O)-O-W535, -NH-C(O)-NH-W536, -NH-C(O)-NW537W538, -NW539-C(O)-O-W540, -NW541 C(O)-NH-W542, -NW543-C(O)-NW544W545, -NHS(O 2 )-W546, 25 -NW547S(0 2 )-W548, -S-W549, -S(O)-W550, -S(0 2 )-W551, S(0 2 )NH-W552, -S(0 2 )NW553W554, -S(0 2 )0-W555, P(O)(OW556)(OW557), -Si(W558)(W559)(W560)"; where W509, W510, W511, W512, W513, W514, W515, W516, W517, W518, W519, W520, W521, W522, W523, W524, W525, 30 W526, W527, W528, W529, W530, W531, W532, W533, W534, W535, W536, W537, W538, W539, W540, W541, W542, W543, W544, W545, W546, W547, W548, W549, W550, W551, W552, W553, W554, W555, W556, W557, W558, W559, W560 are each independently selected from the group consisting of: "alkyl, (C9- W02007/054556 PCT/EP2006/068322 -352 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W515, W516 and/or W524, W525 and/or W537, W538 and/or W544, W545 and/or W553, W554, in each case together, may also 5 form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHW561, -NW562W563, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W564, -C(O)O-W565, 15 -C(O)NH-W566, -C(O)NW567W568, -O-W569, -O(-W570 O)z-H (z = 1, 2, 3, 4, 5), -O(-W571-O)z-W572 (z = 1, 2, 3, 4, 5), -OC(O)-W573, -OC(O)-O-W574, -OC(O)-NHW575, -0 C(O)-NW576W577, -OP(O)(OW578)(OW579), OSi(W580)(W581)(W582), -OS(0 2 )-W583, -NHC(O)-W584, 20 -NW585C(O)-W586, -NH-C(O)-O-W587, -NH-C(O)-NH W588, -NH-C(O)-NW589W590, -NW591-C(O)-O-W592, NW593-C(O)-NH-W594, -NW595-C(O)-NW596W597, NHS(0 2 )-W598, -NW599S(0 2 )-W600, -S-W601, -S(O) W602, -S(0 2 )-W603, -S(0 2 )NH-W604, -S(0 2 )NW605W606, 25 -S(0 2 )O-W607, -P(O)(OW608)(OW609), Si(W610)(W61 1)(W612)"; where W561, W562, W563, W564, W565, W566, W567, W568, W569, W570, W571, W572, W573, W574, W575, W576, W577, W578, W579, W580, W581, W582, W583, 30 W584, W585, W586, W587, W588, W589, W590, W591, W592, W593, W594, W595, W596, W597, W598, W599, W600, W601, W602, W603, W604, W605, W606, W607, W608, W609, W610, W611, W612 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, W02007/054556 PCT/EP2006/068322 - 353 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W567, W568 and/or W576, W577 and/or W589, W590 and/or W596, W597 and/or W605, W606, in each case together, may 5 also form "heterocyclyl"; (e) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW613, -NW614W615, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W616, -C(O)O-W617, -C(O)NH-W618, 15 C(O)NW619W620, -O-W621, -0(-W622-0)a-H (a = 1, 2, 3, 4, 5), O(-W623-0)-W624 (a = 1, 2, 3, 4, 5), -OC(O)-W625, -OC(O)-O W626, -OC(O)-NHW627, -O-C(O)-NW628W629, OP(O)(OW630)(OW631), -OSi(W632)(W633)(W634), -OS(0 2 ) W635, -NHC(O)-W636, -NW637C(O)-W638, -NH-C(O)-O-W639, 20 NH-C(O)-NH-W640, -NH-C(O)-NW641W642, -NW643-C(O)-O W644, -NW645-C(O)-NH-W646, -NW647-C(O)-NW648W649, NHS(0 2 )-W650, -NW651S(0 2 )-W652, -S-W653, -S(O)-W654, S(0 2 )-W655, -S(0 2 )NH-W656, -S(0 2 )NW657W658, -S(0 2 )O-W659, -P(O)(OW660)(OW661), -Si(W662)(W663)(W664)"; 25 where W613, W614, W615, W616, W617, W618, W619, W620, W621, W622, W623, W624, W625, W626, W627, W628, W629, W630, W631, W632, W633, W634, W635, W636, W637, W638, W639, W640, W641, W642, W643, W644, W645, W646, W647, W648, W649, W650, W651, W652, W653, W654, W655, W656, W657, 30 W658, W659, W660, W661, W662, W663, W664 are each independently selected from the group consisting of: "alkyl, (C9 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W02007/054556 PCT/EP2006/068322 -354 W619, W620 and/or W628, W629 and/or W641, W642 and/or W648, W649 and/or W657, W658, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 5 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW665, -NW666W667, -NO 2 , -OH, 10 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W668, -C(O)O-W669, -C(O)NH W670, -C(O)NW671W672, -O-W673, -O(-W674-O)b-H (b = 1, 2, 3, 4, 5), -O(-W675-O)b-W676 (b = 1, 2, 3, 4, 5), -OC(O) W677, -OC(O)-O-W678, -OC(O)-NHW679, -0-C(O) 15 NW680W681, -OP(O)(OW682)(OW683), OSi(W684)(W685)(W686), -OS(0 2 )-W687, -NHC(O)-W688, NW689C(O)-W690, -NH-C(O)-O-W691, -NH-C(O)-NH-W692, -NH-C(O)-NW693W694, -NW695-C(O)-O-W696, -NW697 C(O)-NH-W698, -NW699-C(O)-NW700W701, -NHS(0 2 )-W702, 20 -NW703S(0 2 )-W704, -S-W705, -S(O)-W706, -S(0 2 )-W707, S(0 2 )NH-W708, -S(O 2 )NW709W710, -S(0 2 )O-W711, P(O)(OW712)(OW713), -Si(W714)(W715)(W716)"; where W665, W666, W667, W668, W669, W670, W671, W672, W673, W674, W675, W676, W677, W678, W679, W680, W681, 25 W682, W683, W684, W685, W686, W687, W688, W689, W690, W691, W692, W693, W694, W695, W696, W697, W698, W699, W700, W701, W702, W703, W704, W705, W706, W707, W708, W709, W710, W71 1, W712, W713, W714, W715, W716 are each independently selected from the group consisting of: "alkyl, (C9 30 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W671, W672 and/or W680, W681 and/or W693, W694 and/or W700, W701 and/or W709, W710, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 355 where, optionally,.the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW717, -NW718W719, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W720, -C(O)O-W721, 10 -C(O)NH-W722, -C(O)NW723W724, -O-W725, -O(-W726 O)c-H (c = 1, 2, 3, 4, 5), -O(-W727-O)c-W728 (c = 1, 2, 3, 4, 5), -OC(O)-W729, -OC(O)-O-W730, -OC(O)-NHW731, -0 C(O)-NW732W733, -OP(O)(OW734)(OW735), OSi(W736)(W737)(W738), -OS(0 2 )-W739, -NHC(O)-W740, 15 -NW741C(O)-W742, -NH-C(O)-O-W743, -NH-C(O)-NH W744, -NH-C(O)-NW745W746, -NW747-C(O)-O-W748, NW749-C(O)-NH-W750, -NW751-C(O)-NW752W753, NHS(0 2 )-W754, -NW755S(0 2 )-W756, -S-W757, -S(O) W758, -S(0 2 )-W759, -S(0 2 )NH-W760, -S(0 2 )NW761W762, 20 -S(0 2 )O-W763, -P(O)(OW764)(OW765), Si(W766)(W767)(W768)"; where W717, W718, W719, W720, W721, W722, W723, W724, W725, W726, W727, W728, W729, W730, W731, W732, W733, W734, W735, W736, W737, W738, W739, 25 W740, W741, W742, W743, W744, W745, W746, W747, W748, W749, W750, W751, W752, W753, W754, W755, W756, W757, W758, W759, W760, W761, W762, W763, W764, W765, W766, W767, W768 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, 30 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W723, W724 and/or W732, W733 and/or W745, W746 and/or W752, W753 and/or W761, W762, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 356 (f) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW769, -NW770W771, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-W772, -C(O)O-W773, -C(O)NH-W774, 10 C(O)NW775W776, -O-W777, -O(-W778-O)d-H (d = 1, 2, 3, 4, 5), O(-W77 9 -O)d-W 78 0 (d = 1, 2, 3, 4, 5), -OC(O)-W781, -OC(O)-O W782, -OC(O)-NHW783, -O-C(O)-NW784W785, OP(O)(OW786)(OW787), -OSi(W788)(W789)(W790), -OS(0 2 ) W791, -NHC(O)-W792, -NW793C(O)-W794, -NH-C(O)-O-W795, 15 NH-C(O)-NH-W796, -NH-C(O)-NW797W798, -NW799-C(O)-O W800, -NW801-C(O)-NH-W802, -NW803-C(O)-NW804W805, NHS(O 2 )-W806, -NW807S(O 2 )-W808, -S-W809, -S(O)-W810, S(0 2 )-W81 1, -S(O 2 )NH-W812, -S(O 2 )NW813W814, -S(0 2 )O-W815, -P(O)(OW816)(OW817), -Si(W818)(W819)(W820)"; 20 where W769, W770, W771, W772, W773, W774, W775, W776, W777, W778, W779, W780, W781, W782, W783, W784, W785, W786, W787, W788, W789, W790, W791, W792, W793, W794, W795, W796, W797, W798, W799, W800, W801, W802, W803, W804, W805, W806, W807, W808, W809, W81 0, W81 1, W812, W813, 25 W814, W815, W816, W817, W818, W819, W820 are each independently selected from the group consisting of: "alkyl, (Cs C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W775, W776 and/or W784, W785 and/or W797, W798 and/or W804, 30 W805 and/or W813, W814, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 357 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW821, -NW822W823, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W824, -C(O)O-W825, -C(O)NH W826, -C(O)NW827W828, -O-W829, -0(-W830-0)e-H (e = 1, 10 2, 3, 4, 5), -O(-W831-0).-W832 (e = 1, 2, 3, 4, 5), -OC(O) W833, -OC(O)-O-W834, -OC(O)-NHW835, -0-C(O) NW836W837, -OP(O)(OW838)(OW839), OSi(W840)(W841)(W842), -OS(0 2 )-W843, -NHC(O)-W844, NW845C(O)-W846, -NH-C(O)-O-W847, -NH-C(O)-NH-W848, 15 -NH-C(O)-NW849W850, -NW851-C(O)-O-W852, -NW853 C(O)-NH-W854, -NW855-C(O)-NW856W857, -NHS(0 2 )-W858, -NW859S(0 2 )-W860, -S-W861, -S(O)-W862, -S(0 2 )-W863, S(0 2 )NH-W864, -S(0 2 )NW865W866, -S(0 2 )O-W867, P(O)(OW868)(OW869), -Si(W870)(W871)(W872)"; 20 where W821, W822, W823, W824, W825, W826, W827, W828, W829, W830, W831, W832, W833, W834, W835, W836, W837, W838, W839, W840, W841, W842, W843, W844, W845, W846, W847, W848, W849, W850, W851, W852, W853, W854, W855, W856, W857, W858, W859, W860, W861, W862, W863, W864, 25 W865, W866, W867, W868, W869, W870, W871, W872 are each independently selected from the group consisting of: "alkyl, (C C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W827, W828 and/or W836, W837 and/or W849, W850 and/or 30 W856, W857 and/or W865, W866, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one W02007/054556 PCT/EP2006/068322 -358 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 5 Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW873, -NW874W875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W876, -C(O)O-W877, -C(O)NH-W878, -C(O)NW879W880, -O-W881, -O(-W882 O)r-H (f = 1, 2, 3, 4, 5), -O(-W883-O)r-W884 (f = 1, 2, 3, 4, 5), 10 -OC(O)-W885, -OC(O)-O-W886, -OC(O)-NHW887, -0 C(O)-NW888W889, -OP(O)(OW890)(OW891), OSi(W892)(W893)(W894), -OS(0 2 )-W895, -NHC(O)-W896, -NW897C(O)-W898, -NH-C(O)-O-W899, -NH-C(O)-NH W900, -NH-C(O)-NW901W902, -NW903-C(O)-O-W904, 15 NW905-C(O)-NH-W906, -NW907-C(O)-NW908W909, NHS(0 2 )-W910, -NW911S(0 2 )-W912, -S-W913, -S(O) W914, -S(0 2 )-W915, -S(0 2 )NH-W916, -S(0 2 )NW917W918, -S(0 2 )O-W919, -P(O)(OW920)(OW921), Si(W922)(W923)(W924)"; 20 where W873, W874, W875, W876, W877, W878, W879, W880, W881, W882, W883, W884, W885, W886, W887, W888, W889, W890, W891, W892, W893, W894, W895, W896, W897, W898, W899, W900, W901, W902, W903, W904, W905, W906, W907, W908, W909, W910, W91 1, 25 W912, W913, W914, W915, W916, W917, W918, W919, W920, W921, W922, W923, W924 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 30 W879, W880 and/or W888, W889 and/or W901, W902 and/or W908, W909 and/or W917, W918, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 359 (g) OZ6 where Z6 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 5 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHW925, -NW926W927, -NO 2 , -OH, 10 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W928, -C(O)O-W929, -C(O)NH W930, -C(O)NW931W932, -0-W933, -0(-W934-0)g-H (g = 1, 2, 3, 4, 5), -0(-W935-O)g-W 936 (g = 1, 2, 3, 4, 5), -OC(O) W937, -OC(O)-O-W938, -OC(O)-NHW939, -0-C(O) 15 NW940W941, -OP(O)(OW942)(OW943), OSi(W944)(W945)(W946), -OS(0 2 )-W947, -NHC(O)-W948, NW949C(O)-W950, -NH-C(O)-O-W951, -NH-C(O)-NH-W952, -NH-C(O)-NW953W954, -NW955-C(O)-O-W956, -NW957 C(O)-NH-W958, -NW959-C(O)-NW960W961, -NHS(0 2 )-W962, 20 -NW963S(0 2 )-W964, -S-W965, -S(O)-W966, -S(0 2 )-W967, S(0 2 )NH-W968, -S(0 2 )NW969W970, -S(0 2 )O-W971, P(O)(OW972)(OW973), -Si(W974)(W975)(W976)"; where W925, W926, W927, W928, W929, W930, W931, W932, W933, W934, W935, W936, W937, W938, W939, W940, W941, 25 W942, W943, W944, W945, W946, W947, W948, W949, W950, W951, W952, W953, W954, W955, W956, W957, W958, W959, W960, W961, W962, W963, W964, W965, W966, W967, W968, W969, W970, W971, W972, W973, W974, W975, W976 are each independently selected from the group consisting of: "alkyl, (CO 30 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W931, W932 and/or W940, W941 and/or W953, W954 and/or W02007/054556 PCT/EP2006/068322 - 360 W960, W961 and/or W969, W970, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 5 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW977, -NW978W979, -NO 2 , 10 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W980, -C(O)O-W981, -C(O)NH-W982, -C(O)NW983W984, -O-W985, -O(-W986 O)h-H (h = 1, 2, 3, 4, 5), -O(-W987-O)h-W988 (h = 1, 2, 3, 4, 5), -OC(O)-W989, -OC(O)-O-W990, -OC(O)-NHW991, -0 15 C(O)-NW992W993, -OP(O)(OW994)(OW995), OSi(W996)(W997)(W998), -OS(0 2 )-W999, -NHC(O)-W 1000, -NW1001 C(O)-W1002, -NH-C(O)-O-W1003, -NH-C(O) NH-W1004, -NH-C(O)-NW1005W1006, -NW1007-C(O)-O W1008, -NW1009-C(O)-NH-W1010, -NW1011-C(O) 20 NW1012W1013, -NHS(0 2 )-W1014, -NW1015S(O 2 )-W1016, -S-W1017, -S(O)-W1018, -S(0 2 )-W1019, -S(0 2 )NH W1020, -S(0 2 )NW1021W1022, -S(0 2 )O-W1023, P(O)(OW1024)(OW1025), -Si(W1026)(W1027)(W1028)"; where W977, W978, W979, W980, W981, W982, W983, 25 W984, W985, W986, W987, W988, W989, W990, W991, W992, W993, W994, W995, W996, W997, W998, W999, W1000, W1001, W1002, W1003, W1004, W1005, W1006, W1007, W1008, W1009, W1010, W1011, W1012, W1013, W1014, W1015, W1016, W1017, W1018, W1019, W1020, 30 W1021, W1022, W1023, W1024, W1025, W1026, W1027, W1028 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W983, W984 and/or W020071054556 PCT/EP2006/068322 - 361 W992, W993 and/or W1005, W1006 and/or W1012, W1013 and/or W1021, W1022, in each case together, may also form "heterocyclyl"; 5 (h) SZ7 where Z7 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 10 selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1029, -NW1030W1031, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 15 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1032, -C(O)O-W1033, C(O)NH-W1034, -C(O)NW1035W1036, -O-W1037, -O( W1038-O)r-H (i = 1, 2, 3, 4, 5), -O(-W1039-0)i-W1040 (i = 1, 2, 3, 4, 5), -OC(O)-W1041, -OC(O)-O-W1042, -OC(O)-NHW1043, -O-C(O)-NW1044W1045, -OP(O)(OW1046)(OW1047), 20 OSi(W1048)(W1049)(W1050), -OS(0 2 )-W1051, -NHC(O) W1052, -NW1053C(O)-W1054, -NH-C(O)-O-W1055, -NH C(O)-NH-W1056, -NH-C(O)-NW1 057W1058, -NW1 059-C(O) O-W1060, -NW1061-C(O)-NH-W1062, -NW1 063-C(O) NW1064W1065, -NHS(0 2 )-W1066, -NW1067S(O 2 )-W1068, -S 25 W1069, -S(O)-W1070, -S(0 2 )-W1071, -S(0 2 )NH-W1072, S(0 2 )NW1073W1074, -S(0 2 )O-W1075, P(O)(OW1076)(OW1077), -Si(W1078)(W1079)(W1080)"; where W1029, W1030, W1031, W1032, W1033, W1034, W1035, W1036, W1037, W1038, W1039, W1040, W1041, W1042, W1043, 30 W1044, W1045, W1046, W1047, W1048, W1049, W1050, W1051, W1052, W1053, W1054, W1055, W1056, W1057, W1058, W1059, W1060, W1061, W1062, W1063, W1064, W1065, W1066, W1067, W1068, W1069, W1070, W1071, W1072, W1073, W1074, W1075, W02007/054556 -362- PCT/EP2006/068322 W1076, W1077, W1078, W1079, W1080 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 5 W1035, W1036 and/or W1044, W1045 and/or W1057, W1058 and/or W1064, W1065 and/or W1073, W1074, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 10 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-Co)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1081, -NW1082W1083, 15 NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1084, C(O)O-W1085, -C(O)NH-W1086, -C(O)NW1 087W1088, -0 W1089, -O(-W1090-0);-H (j = 1, 2, 3, 4, 5), -O(-W1O 9 1-O); W1092 (j = 1, 2, 3, 4, 5), -OC(O)-W1093, -OC(O)-O-W1094, 20 -OC(O)-NHW1095, -O-C(O)-NW1096W1097, OP(O)(OW1098)(OW1099), -OSi(W1 100)(W1 101)(W1 102), OS(0 2 )-W 1103, -NHC(O)-W 1104, -NW1 105C(O)-W 1106, NH-C(O)-O-W 1107, -NH-C(O)-NH-W 1108, -NH-C(O) NW1109W1110, -NW1111-C()-O-W1112, -NW1113 25 C(O)-NH-W1114, -NW1115-C(O)-NW1116W1117, NHS(0 2 )-W1118, -NW1119S(0 2 )-W1120, -S-W1121, S(O)-W1122, -S(0 2 )-W1123, -S(0 2 )NH-W1124, S(0 2 )NW1125W 1126, -S(0 2 )O-W1127, P(O)(OW1128)(OW1129), -Si(W1130)(W1131)(W1132)"; 30 where W1081, W1082, W1083, W1084, W1085, W1086, W1087, W1088, W1089, W1090, W1091, W1092, W1093, W1094, W1095, W1096, W1097, W1098, W1099, W1 100, W1101, W1102, W1103, W1104, W1105, W1106, W1107, W1108, W1109, W1110, W1111, W1112, W1113, W1114, W02007/054556 PCT/EP2006/068322 - 363 W1115, W1116, W1117, W1118, W1119, W1120, W1121, W1122, W1123, W1124, W1125, W1126, W1127, W1128, W1129, W1130, W1131, W1132 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, 5 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W1087, W1088 and/or W1096, W1097 and/or W1109, W1110 and/or W1116, W1117 and/or W1125, W1126, in each case together, may also form "heterocyclyl"; 10 (j) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) 15 W1133, -C(O)O-W1134, -C(O)-NW1135W1136, -S(0 2 )-W1137, S(0 2 )O-W1138"; where W1133, W1134, W1135, W1136, W1137, W1138 are each independently selected from the group consisting of: hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 20 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W1135, W1 136 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 25 (ii) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1139, -NW1140W1141, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1142, -C(0)O-W 1143, 30 C(O)NH-W1144, -C(O)NW1145W1146, -O-W1147, -O( W1148-O)k-H (k = 1, 2, 3, 4, 5), -O(-W1149-O)k-W1150 (k = 1, 2, 3, 4, 5), -OC(O)-Wl151, -OC(O)-O-W1152, -OC(O) NHW1153, -O-C(O)-NW1154W1155, - W02007/054556 PCT/EP20061068322 - 364 OP(O)(OW1156)(OW1157), -OSi(W158)(W1159)(W1160), OS(0 2 )-W1 161, -NHC(O)-W1 162, -NW1 163C(O)-Wi 164, -NH C(O)-O-W1 165, -NH-C(O)-NH-W1 166, -NH-C(O) NW1167W1168, -NW1169-C(O)-O-W1170, -NW1171-C(O) 5 NH-W 1172, -NW 1 173-C(O)-NW1 174W 1175, -NHS(0 2 )-W 1176, -NW1 177S(0 2 )-W 1178, -S-W 1179, -S(O)-W 1180, -S(0 2 ) W1181, -S(0 2 )NH-W 1182, -S(0 2 )NW1 183W 1184, -S(0 2 )O W1185, -P(O)(OW1186)(OW1187), Si(W1 188)(W1 189)(W1 190)"; 10 where Wl139, W1140, W1141, W1142, W1143, W114 4 , W145, W1146, W1147, W1148, W1149, W 150, W 151, W1152, W1153, W1154, W1155, W1156, W1157, W1158, W1159, W1160, W1161, W1162, W1163, W1164, W1165, W1166, W1167, W1168, W1169, W1170, W1171, W1172, W1173, W1174, W1175, W1176, W1177, 15 W1178, W1179, W1180, W1181, W1182, W1183, W1184, W1185, W1186, W1187, W1188, W1189, W1190 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 20 W1145, W1146 and/or Wl154, W1155 and/or W1167, W1168 and/or W1174, W1175 and/or W1183, W1184, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 25 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHW1191, -NW1192W1193, 30 NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-W1194, C(O)O-W1195, -C(O)NH-W1196, -C(O)NW1197W1 198, -0 W1199, -0(-W1200-0)r-H (I = 1, 2, 3, 4, 5), -0(-W1201-O)r W1202 (I = 1, 2, 3, 4, 5), -OC(O)-W1203, -OC(O)-O-W1204, W02007/054556 PCT/EP20061068322 - 365 -OC(O)-NHW1205, -O-C(O)-NW1206W1207, OP(O)(OW1208)(OW1209), -OSi(W1210)(W1211)(W1212), OS(0 2 )-W1213, -NHC(O)-W1214, -NW1215C(O)-W1216, NH-C(O)-O-W1217, -NH-C(O)-NH-W1218, -NH-C(O) 5 NW1219W1220, -NW1221-C(O)-O-W1222, -NW1223 C(O)-NH-W1224, -NW1225-C(O)-NW1226W1227, NHS(0 2 )-W1228, -NW1229S(0 2 )-W1230, -S-W1231, S(O)-W1232, -S(0 2 )-W1233, -S(0 2 )NH-W1234, S(0 2 )NW1235W1236, -S(0 2 )O-W1237, 10 P(O)(OW1238)(OW1239), -Si(W1240)(W1241)(W1242)"; where W1191, W1192, W1193, W1194, W1195, W1196, W1197, W1198, W1199, W1200, W1201, W1202, W1203, W1204, W1205, W1206, W1207, W1208, W1209, W1210, W1211, W1212, W1213, W1214, W1215, W1216, W1217, 15 W1218, W1219, W1220, W1221, W1222, W1223, W1224, W1225, W1226, W1227, W1228, W1229, W1230, W1231, W1232, W1233, W1234, W1235, W1236, W1237, W1238, W1239, W1240, W1241, W1242 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, 20 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W1197, W1198 and/or W1206, W1207 and/or W1219, W1220 and/or W1226, W1227 and/or W1235, W1236, in each case together, may also form "heterocyclyl"; 25 or (D) one of the Z3, Z4 radicals or both Z3, Z4 radicals are each independently selected from the group consisting of: 30 (1) "-NZ1OZ11, -OZ12, -SZ13"; where one of the Z10, Z1 1 radicals or both Z10, Z1 1 radicals and Z12, Z13 radicals are each independently selected from the group consisting of: W02007/054556 PCT/EP2006/068322 - 366 (a) "hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl"; with the proviso that both Z1 0, Z1 1 radicals are not simultaneously hydrogen; 5 with the further proviso that the Z12 radical is not hydrogen; with the further proviso that the above substituents of substituent group (a), when they are not hydrogen, are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: 10 (i) "(C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, N 3 , -NH cycloalkyl, -NH-cycloalkylalkyl, -NH-heteroaryl, -NH-heteroarylalkyl, -NH-arylalkyl, -NH-heterocyclyl, -NH-heterocyclylalkyl, -NQ1Q2, S-cycloalkyl, -S-cycloalkylalkyl, -S-aryl, -S-arylalkyl, -S-heteroaryl, 15 -S-heteroarylalkyl, -S-heterocyclyl, -S-heterocyclylalkyl, -0 cycloalkyl, -0-cycloalkylalkyl, -0-arylalkyl, -0-heteroaryl, -0 heteroarylalkyl, -0-heterocyclyl, -0-heterocyclylalkyl, -O(-Q3-O), H (p = 1, 2, 3, 4, 5), -0(-Q4-0)0-Q5 (p = 1, 2, 3, 4, 5), OP(O)(OQ6)(OQ7), -C(O)O-Q8, -C(O)NH 2 , -C(O)NH-Q9, 20 C(O)NQ1 0Q11, -S(0 2 )-Q1 2, -P(O)(OH) 2 , -P(O)(OQ1 3)(OQ1 4), Si(Q15)(Q16)(Q17), -O-Si(Q18)(Q19)(Q20), -0-C(O)-O-Q21, -0 C(O)-NH-Q22, -0-C(O)-NQ23Q24, -NH-C(O)-O-Q25, -NH-C(O) NH-Q26, -NH-C(O)-NQ27Q28, -NQ29-C(O)-0-Q30, -NQ31 C(O)-NH-Q32, -NQ33-C(O)-NQ34Q35, -NQ36-S(0 2 )-Q37, -NH 25 S(0 2 )-Q38, -0-S(0 2 )-Q39, -NH-C(O)-Q40, -NQ41-C(O)-Q42, C(O)-Q43, -OC(O)-Q44, -S(O)-Q45, -S(0 2 )-NHQ46, -S(O2) NQ47Q48, -S(0 2 )-OQ49"; with the further proviso that "-N(alkyl) 2 " is further substituted by at least one substituent selected from the following substituent group (ii); 30 where Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8, 09, Q10, Q11, Q12, Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q20, Q21, Q22, Q23, Q24, Q25, Q26, Q27, Q28, Q29, Q30, Q31, Q32, Q33, Q34, Q35, Q36, Q37, Q38, Q39, Q40, Q41, Q42, Q43, Q44, Q45, Q46, Q47, Q48, Q49 are W02007/054556 PCT/EP2006/068322 - 367 each independently selected from the group consisting of: "alkyl, (C C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q10, Q1 1 and/or Q23, Q24 and/or Q27, Q28 and/or Q34, 035 and/or 5 Q47, Q48, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (a) and/or of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, C1, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ50, -NQ51Q52, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , SO 3 H, -P(O)(OH) 2 , -C(O)-Q53, -C(O)O-Q54, -C(O)NH-Q55, 15 C(O)NQ56Q57, -O-Q58, -O(-Q59-O),-H (r = 1, 2, 3, 4, 5), -O( Q60-0)r-Q61 (r = 1, 2, 3, 4, 5), -OC(O)-Q62, -OC(O)-O-Q63, OC(O)-NHQ64, -O-C(O)-NQ65Q66, -OP(O)(OQ67)(OQ68), OSi(Q69)(Q70)(Q71), -OS(0 2 )-Q72, -NHC(O)-Q73, NQ74C(O)-Q75, -NH-C(O)-O-Q76, -NH-C(O)-NH-Q77, -NH 20 C(O)-NQ78Q79, -NQ80-C(O)-O-Q81, -NQ82-C(O)-NH-Q83, NQ84-C(O)-NQ85Q86, -NHS(0 2 )-Q87, -NQ88S(0 2 )-Q89, -S Q90, -S(O)-Q91, -S(0 2 )-Q92, -S(0 2 )NH-Q93, -S(0 2 )NQ94Q95, -S(0 2 )O-Q96, -P(O)(OQ97)(OQ98), -Si(Q99)(Q100)(Q101)"; where Q50, Q51, Q52, Q53, Q54, Q55, Q56, Q57, Q58, Q59, Q60, 25 Q61, Q62, Q63, Q64, Q65, Q66, Q67, Q68, Q69, Q70, Q71, Q72, Q73, Q74, Q75, Q76, Q77, Q78, Q79, Q80, Q81, Q82, Q83, Q84, Q85, Q86, Q87, Q88, Q89, Q90, Q91, Q92, Q93, Q94, Q95, Q96, Q97, Q98, Q99, Q100, Q101 are each independently selected from the group consisting of: "alkyl, (CO-C 30 )alkyl, cycloalkyl, 30 cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q56, Q57 and/or Q65, Q66 and/or Q78, Q79 and/or Q85, Q86 and/or Q94, Q95, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 368 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ102, -NQ103Q104, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1O5, -C(O)O-Q106, 10 C(O)NH-Q107, -C(O)NQ108Q109, -O-Q110, -O(-Q1 11 O),-H (s = 1, 2, 3, 4, 5), -O(-Q112-O),-Q113 (s = 1, 2, 3, 4, 5), -OC(O)-Ql 14, -OC(O)-O-Q1 15, -OC(O)-NHQ1 16, -0 C(O)-NQ1 17Q1 18, -OP(O)(OQ1 19)(OQ120), OSi(Q121)(Q122)(Q123), -OS(O 2 )-Q124, -NHC(O)-Q125, 15 NQ126C(O)-Q127, -NH-C(O)-O-Q128, -NH-C(O)-NH Q129, -NH-C(O)-NQ130Q131, -NQ132-C(O)-O-Q133, NQ134-C(O)-NH-Q135, -NQ136-C(O)-NQ137Q138, NHS(0 2 )-Q139, -NQ140S(O 2 )-Q141, -S-Q142, -S(O)-Q143, -S(0 2 )-Q144, -S(0 2 )NH-Q145, -S(0 2 )NQ146Q147, 20 S(0 2 )O-Q148, -P(O)(OQ149)(OQ150), Si(Q1 51)(Q1 52)(Q1 53)"; where Q102, Q103, Q104, Q105, Q106, Q107, Q108, Q109, Q110, Q111, Q112, Q113, Q114, Q115, Q116, Q117, Q118, Q119, Q120, Q121, Q122, Q123, Q124, Q125, Q126, Q127, 25 Q128, Q129, Q130, Q131, Q132, Q133, Q134, Q135, Q136, Q137, Q138, Q139, Q140, Q141, Q142, Q143, Q144, Q145, Q146, Q147, Q148, Q149, Q150, Q151, Q152, Q153 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q108, Q109 and/or Q117, Q118 and/or Q130, Q131 and/or Q137, Q138 and/or Q146, Q147, in each case together, may also form "heterocyclyl"; W020071054556 PCT/EP2006/068322 - 369 (b) "(C 9 -C 30 )alkyl, -C(O)-Q154, -C(O)O-Q1 55, -C(O)-NQ156Q157, -S(0 2 ) Q158, -S(O 2 )O-Q159"; where Q154, Q155, Q156, Q157, Q158, Q159 are each independently selected from the group consisting of: "hydrogen, alkyl, (C 9 -C 30 )alkyl, 5 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q156, Q157 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (b) may in turn each independently be substituted by at least one substituent 10 selected identically or differently from the group consisting of: (i) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ160, -NQ161Q162, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 15 P(O)(OH) 2 , -C(O)-Q163, -C(0)0-0164, -C(O)NH-Q165, C(O)NQ166Q167, -O-Q168, -O(-Q169-O)t-H (t = 1, 2, 3, 4, 5), -O( Q170-O)t-Q171 (t = 1, 2, 3, 4, 5), -OC(O)-Q172, -OC(O)-O-Q173, OC(O)-NHQ174, -O-C(O)-NQ175Q176, -OP(O)(OQ177)(OQ178), OSi(Q179)(Q180)(Q181),;-OS(O 2 )-Q182, -NHC(O)-Q183, 20 NQ184C(O)-Q185, -NH-C(O)-O-Q186, -NH-C(O)-NH-Q187, NH-C(O)-NQ188Q189, -NQ190-C(O)-O-Q191, -NQ192-C(O)-NH Q193, -NQ194-C(O)-NQ195Q196, -NHS(0 2 )-Q197, -NQ198S(0 2 ) Q199, -S-Q200, -S(O)-Q201, -S(0 2 )-Q202, -S(0 2 )NH-Q203, S(0 2 )NQ204Q205, -S(0 2 )O-Q206, -P(O)(OQ207)(OQ208), 25 Si(Q209)(Q21 0)(Q21 1)"; where Q160, Q161, 0162, 0163, Q164, Q165, Q166, Q167, Q168, Q169, Q170, Q171, Q172, Q173, Q174, Q175, Q176, Q177, Q178, Q179, Q180, Q181, Q182, Q183, Q184, Q185, Q186, Q187, Q188, Q189, Q190, Q191, Q192, Q193, Q194, Q195, Q196, Q197, Q198, 30 Q199, Q200, Q201, Q202, Q203, Q204, Q205, Q206, Q207, Q208, Q209, Q210, Q211 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, W02007/054556 PCT/EP2006/068322 -370 heteroarylalkyl" and where, alternatively, Q166, Q167 and/or Q175, Q176 and/or Q188, Q189 and/or Q195, Q196 and/or Q204, Q205, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 5 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ212, -NQ213Q214, -NO 2 , -OH, 10 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q215, -C(O)O-Q216, -C(O)NH Q217, -C(O)NQ218Q219, -O-Q220, -O(-Q221-O),-H (u = 1, 2, 3, 4, 5), -O(-Q222-O),-Q223 (u = 1, 2, 3, 4, 5), -OC(O)-Q224, OC(O)-O-Q225, -OC(O)-NHQ226, -O-C(O)-NQ227Q228, 15 OP(O)(OQ229)(OQ230), -OSi(Q231)(Q232)(Q233), -OS(0 2 ) Q234, -NHC(O)-Q235, -NQ236C(O)-Q237, -NH-C(O)-O-Q238, -NH-C(O)-NH-Q239, -NH-C(O)-NQ240Q241, -NQ242-C(O) 0-0243, -NQ244-C(O)-NH-Q245, -NQ246-C(O)-NQ247Q248, -NHS(0 2 )-Q249, -NQ250S(0 2 )-Q251, -S-Q252, -S(O)-Q253, 20 S(0 2 )-Q254, -S(0 2 )NH-Q255, -S(0 2 )NQ256Q257, -S(0 2 )O Q258, -P(O)(OQ259)(OQ260), -Si(Q261)(Q262)(Q263)"; where Q212, Q213, Q214, Q215, Q216, Q217, Q218, Q219, Q220, Q221, Q222, Q223, Q224, Q225, Q226, Q227, Q228, Q229, Q230, Q231, Q232, Q233, Q234, Q235, Q236, Q237, 25 Q238, Q239, Q240, Q241, Q242, Q243, Q244, Q245, Q246, Q247, Q248, Q249, Q250, Q251, Q252, Q253, Q254, Q255, Q256, Q257, Q258, Q259, Q260, Q261, Q262, Q263 are each independently selected from the group consisting of: "alkyl, (C C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, 30 aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q218, Q219 and/or Q227, Q228 and/or Q240, Q241 and/or Q247, Q248 and/or Q256, Q257, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -371 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ264, -NQ265Q266, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q267, -C(O)O-Q268, 10 C(O)NH-Q269, -C(O)NQ270Q271, -O-Q272, -O(-Q273 O)X-H (v = 1, 2, 3, 4, 5), -O(-Q274-O),-Q275 (v = 1, 2, 3, 4, 5), -OC(O)-Q276, -OC(O)-O-Q277, -OC(O)-NHQ278, -0 C(O)-NQ279Q280, -OP(O)(OQ281)(OQ282), OSi(Q283)(Q284)(Q285), -OS(0 2 )-Q286, -NHC(O)-Q287, 15 NQ288C(O)-Q289, -NH-C(O)-O-Q290, -NH-C(O)-NH Q291, -NH-C(O)-NQ292Q293, -NQ294-C(O)-O-Q295, NQ296-C(O)-NH-Q297, -NQ298-C(O)-NQ299Q300, NHS(0 2 )-Q301, -NQ302S(0 2 )-0303, -S-Q304, -S(O)-Q305, -S(0 2 )-Q306, -S(0 2 )NH-Q307, -S(0 2 )NQ308Q309, 20 S(0 2 )O-Q31 0, -P(O)(OQ31 1)(OQ312), Si(Q313)(Q314)(Q315)"; where Q264, Q265, Q266, Q267, Q268, Q269, Q270, Q271, Q272, Q273, Q274, Q275, Q276, Q277, Q278, Q279, Q280, Q281, Q282, Q283, Q284, Q285, Q286, Q287, Q288, Q289, 25 Q290, Q291, Q292, Q293, Q294, Q295, Q296, Q297, Q298, Q299, Q300, Q301, Q302, Q303, Q304, Q305, Q306, Q307, Q308, Q309, Q310, Q311, Q312, Q313, Q314, Q315 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q270, Q271 and/or Q279, Q280 and/or Q292, Q293 and/or Q299, Q300 and/or Q308, Q309, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -372 or one of the Z1 0, Z1 1 radicals or neither of the Z1 0, Z1 1 radicals are each independently selected from the group consisting of: (c) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -C(O)-Q316, 5 C(O)O-Q317, -C(O)-NQ318Q319, -S(0 2 )-Q320, -S(0 2 )O-Q321"; where Q316, Q317, Q318, Q319, Q320, Q321 are each independently selected from the group consisting of: "hydrogen, alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q318, Q319 together 10 may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (c), when they are not hydrogen, may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (i) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ322, -NQ323Q324, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Q325, -C(O)O-Q326, -C(O)NH-Q327, 20 C(O)NQ328Q329, -O-Q330, -O(-Q331-O).-H (w = 1, 2, 3, 4, 5), O(-Q332-O)w-Q333 (w = 1, 2, 3, 4, 5), -OC(O)-Q334, -OC(O)-O Q335, -OC(O)-NHQ336, -0-C(O)-NQ337Q338, OP(O)(OQ339)(OQ340), -OSi(Q341)(Q342)(Q343), -OS(0 2 )-Q344, NHC(O)-Q345, -NQ346C(O)-Q347, -NH-C(O)-O-Q348, -NH 25 C(O)-NH-Q349, -NH-C(O)-NQ350Q351, -NQ352-C(O)-O-Q353, NQ354-C(O)-NH-Q355, -NQ356-C(O)-NQ357Q358, -NHS(0 2 ) Q359, -NQ360S(0 2 )-Q361, -S-Q362, -S(O)-Q363, -S(0 2 )-Q364, S(0 2 )NH-Q365, -S(0 2 )NQ366Q367, -S(0 2 )O-Q368, P(O)(OQ369)(OQ370), -Si(Q371)(Q372)(Q373)"; 30 where Q322, Q323, Q324, Q325, Q326, Q327, Q328, Q329, Q330, Q331, Q332, Q333, Q334, Q335, Q336, Q337, Q338, Q339, Q340, Q341, Q342, Q343, Q344, Q345, Q346, Q347, Q348, Q349, Q350, Q351, Q352, Q353, Q354, Q355, Q356, Q357, Q358, Q359, Q360, W02007/054556 PCT/EP20061068322 - 373 Q361, 0362, Q363, Q364, Q365, Q366, Q367, Q368, Q369, Q370, Q371, Q372, Q373 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 5 heteroarylalkyl" and where, alternatively, Q328, Q329 and/or Q337, Q338 and/or Q350, Q351 and/or Q357, Q358 and/or Q366, Q367, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 10 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ374, -NQ375Q376, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 15 -SO 3 H, -P(O)(OH) 2 , -C(O)-Q377, -C(O)O-Q378, -C(O)NH Q379, -C(O)NQ380Q381, -O-Q382, -O(-Q383-O),-H (x = 1, 2, 3, 4, 5), -O(-Q384-O)x-Q385 (x = 1, 2, 3, 4, 5), -OC(O)-Q386, OC(O)-O-Q387, -OC(O)-NHQ388, -O-C(O)-NQ389Q390, OP(O)(OQ391)(OQ392), -OSi(Q393)(Q394)(Q395), -OS(0 2 ) 20 Q396, -NHC(O)-Q397, -NQ398C(O)-Q399, -NH-C(O)-O-Q400, -NH-C(O)-NH-Q401, -NH-C(O)-NQ402Q403, -NQ404-C(O) O-Q405, -NQ406-C(O)-N H-Q407, -NQ408-C(O)-NQ409Q410, -NHS(0 2 )-Q411, -NQ412S(0 2 )--Q413, -S-Q414, -S(O)-Q415, S(02)-Q416, -S(0 2 )NH-Q417, -S(0 2 )NQ418Q419, -S(0 2 )O 25 Q420, -P(O)(OQ421)(OQ422), -Si(Q423)(Q424)(Q425)"; where Q374, Q375, Q376, Q377, Q378, Q379, Q380, Q381, Q382, Q383, Q384, Q385, Q386, Q387, Q388, Q389, Q390, Q391, Q392, Q393, Q394, Q395, Q396, Q397, Q398, Q399, Q400, Q401, Q402, Q403, Q404, Q405, Q406, Q407, Q408, 30 Q409, Q410, Q411, Q412, Q413, Q414, Q415, Q416, Q417, Q418, Q419, Q420, 0421, Q422, Q423, Q424, Q425 are each independently selected from the group consisting of: "alkyl, (C C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W02007/054556 PCT/EP2006/068322 -374 Q380, Q381 and/or Q389, Q390 and/or Q402, Q403 and/or Q409, Q410 and/or Q418, Q419, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) 5 may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 10 Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ426, -NQ427Q428, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q429, -C(O)O-Q430, C(O)NH-Q431, -C(O)NQ432Q433, -O-Q434, -O(-Q435 O)y-H (y = 1, 2, 3, 4, 5), -O(-Q436-O)y-Q437 (y = 1, 2, 3, 4, 15 5), -OC(O)-Q438, -OC(O)-O-Q439, -OC(O)-NHQ440, -0 C(O)-NQ441Q442, -OP(O)(OQ443)(OQ444), OSi(Q445)(Q446)(Q447), -OS(0 2 )-Q448, -NHC(O)-Q449, NQ450C(O)-Q451, -NH-C(O)-O-Q452, -NH-C(O)-NH Q453, -NH-C(O)-NQ454Q455, -NQ456a-C(O)-O-Q456b, 20 NQ456c-C(O)-NH-Q456d, -NQ456e-C(O)-NQ456fQ456g, NHS(0 2 )-Q456h, -NQ456iS(0 2 )-Q456j, -S-Q456k, -S(O) Q4561, -S(0 2 )-Q456m, -S(0 2 )NH-Q456n, S(0 2 )NQ4560Q456p, -S(0 2 )O-Q456q, P(O)(OQ456r)(OQ456s), -Si(Q456t)(Q456u)(Q456v)"; 25 where Q426, 0427, Q428, Q429, 0430, Q431, Q432, Q433, Q434, Q435, Q436, Q437, Q438, Q439, Q440, Q441, Q442, Q443, Q444, Q445, Q446, Q447, Q448, Q449, Q450, Q451, Q452, Q453, Q454, Q455, Q456a, Q456b, Q456c, Q456d, Q456e, Q456f, Q456g, Q456h, Q456i, Q456j, Q456k, Q4561, 30 Q456m, Q456n, Q456o, 0456p, Q456q, Q456r, Q456s, Q456t, Q456u, Q456v are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q432, Q433 and/or W02007/054556 PCT/EP2006/068322 -375 Q441, Q442 and/or Q454, Q455 and/or Q456f, Q456g and/or Q456o, Q456p, in each case together, may also form "heterocyclyl"; 5 and one of the Z3, Z4 radicals or neither of the Z3, Z4 radicals is independently selected from the group consisting of: (d) hydrogen; (e) halogen, F, Cl, Br, I; (f) unsubstituted or substituted alkyl or (C 9 -C 30 )alkyl, where, optionally, the 10 alkyl or (C 9 -C 30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ457, -NQ458Q459, -NO 2 , -OH, -OCF 3 , 15 SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Q460, -C(O)O-Q461, -C(O)NH-Q462, C(O)NQ463Q464, -O-Q465, -O(-Q466-O),-H (z = 1, 2, 3, 4, 5), O(-Q467-O)z-Q468 (z = 1, 2, 3, 4, 5), -OC(O)-Q469, -OC(O)-O Q470, -OC(O)-NHQ471, -O-C(O)-NQ472Q473, 20 OP(O)(OQ474)(OQ475), -OSi(Q476)(Q477)(Q478), -OS(0 2 )-Q479, NHC(O)-Q480, -NQ481C(O)-Q482, -NH-C(O)-O-Q483, -NH C(O)-NH-Q484, -NH-C(O)-NQ485Q486, -NQ487-C(O)-O-Q488, NQ489-C(O)-NH-Q490, -NQ491-C(O)-NQ492Q493, -NHS(0 2 ) Q494, -NQ495S(0 2 )-Q496, -S-Q497, -S(O)-Q498, -S(0 2 )-Q499, 25 S(0 2 )NH-Q500, -S(0 2 )NQ501Q502, -S(0 2 )O-Q503, P(O)(OQ504)(OQ505), -Si(Q506)(Q507)(Q508)"; where Q457, Q458, Q459, Q460, Q461, Q462, Q463, Q464, Q465, 0466, Q467, Q468, Q469, Q470, Q471, Q472, Q473, Q474, Q475, Q476, Q477, Q478, Q479, Q480, Q481, Q482, Q483, Q484, Q485, 30 Q486, Q487, Q488, Q489, Q490, Q491, Q492, Q493, Q494, Q495, Q496, Q497, Q498, Q499, 0500, 0501, Q502, Q503, 0504, Q505, Q506, 0507, Q508 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, W02007/054556 PCT/EP2006/068322 - 376 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q463, Q464 and/or Q472, Q473 and/or Q485, Q486 and/or Q492, Q493 and/or Q501, Q502, in each case together, may also form "heterocyclyl"; 5 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 10 Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ509, -NQ510Q511, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q512, -C(O)O-Q513, -C(O)NH Q514, -C(O)NQ515Q516, -O-Q517, -O(-Q518-0)a-H (a = 1, 2, 3, 4, 5), -0(-Q519-0)a-Q520 (a = 1, 2, 3, 4, 5), -OC(O)-Q521, 15 OC(O)-O-Q522, -OC(O)-NHQ523, -O-C(O)-NQ524Q525, OP(O)(OQ526)(OQ527), -OSi(Q528)(Q529)(Q530), -OS(0 2 ) Q531, -NHC(O)-Q532, -NQ533C(O)-Q534, -NH-C(O)-O-Q535, -NH-C(O)-NH-Q536, -NH-C(O)-NQ537Q538, -NQ539-C(O) 0-0540, -NQ541-C(O)-NH-Q542, -NQ543-C(O)-NQ544Q545, 20 -NHS(0 2 )-Q546, -NQ547S(0 2 )-Q548, -S-Q549, -S(O)-Q550, S(0 2 )-Q551, -S(0 2 )NH-Q552, -S(0 2 )NQ553Q554, -S(0 2 )O Q555, -P(O)(OQ556)(OQ557), -Si(Q558)(Q559)(Q560)"; where Q509, Q510, Q511, Q512, Q513, Q514, Q515, Q516, 0517, Q518, Q519, Q520, Q521, Q522, Q523, Q524, Q525, 25 0526, Q527, Q528, Q529, Q530, Q531, Q532, Q533, Q534, Q535, Q536, Q537, Q538, Q539, Q540, Q541, Q542, Q543, Q544, Q545, Q546, Q547, Q548, Q549, 0550, Q551, Q552, Q553, Q554, Q555, Q556, Q557, Q558, Q559, Q560 are each independently selected from the group consisting of: "alkyl, (C9 30 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q515, Q516 and/or Q524, Q525 and/or Q537, 0538 and/or Q544, Q545 and/or Q553, Q554, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 377 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHQ561, -NQ562Q563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q564, -C(O)O-Q565, 10 C(O)NH-Q566, -C(O)NQ567Q568, -0-0569, -O(-Q570 O)b-H (b = 1, 2, 3, 4, 5), -O(-Q571-O)b-Q572 (b = 1, 2, 3, 4, 5), -OC(O)-Q573, -OC(O)-O-Q574, -OC(O)-NHQ575, -0 C(O)-NQ576Q577, -OP(O)(OQ578)(OQ579), OSi(Q580)(Q581)(Q582), -OS(0 2 )-Q583, -NHC(O)-0584, 15 NQ585C(O)-Q586, -NH-C(O)-O-Q587, -NH-C(O)-NH Q588, -NH-C(O)-NQ589Q590, -NQ591-C(O)-O-Q592, NQ593-C(O)-NH-Q594, -NQ595-C(O)-NQ596Q597, NHS(0 2 )-Q598, -NQ599S(0 2 )-Q600, -S-Q601, -S(O)-Q602, -S(0 2 )-Q603, -S(0 2 )NH-Q604, -S(0 2 )NQ605Q606, 20 S(0 2 )O-Q607, -P(O)(OQ608)(OQ609), Si(Q610)(Q61 1)(Q612)"; where Q561, Q562, 0563, Q564, Q565, Q566, Q567, Q568, Q569, Q570, Q571, Q572, Q573, Q574, Q575, Q576, Q577, Q578, Q579, Q580, Q581, Q582, Q583, Q584, Q585, Q586, 25 Q587, Q588, Q589, Q590, Q591, Q592, 0593, Q594, Q595, Q596, Q597, Q598, Q599, Q600, Q601, Q602, Q603, Q604, Q605, Q606, Q607, Q608, Q609, Q610, Q611, Q612 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q567, Q568 and/or 0576, Q577 and/or 0589, Q590 and/or Q596, Q597 and/or 0605, Q606, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 378 (g) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ613, -NQ614Q615, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Q616, -C(O)O-Q617, -C(O)NH-Q618, C(O)NQ619Q620, -O-Q621, -O(-Q622-0)c-H (c = 1, 2, 3, 4, 5), 10 O(-Q623-0)c-Q624 (c = 1, 2, 3, 4, 5), -OC(O)-Q625, -OC(O)-O Q626, -OC(O)-NHQ627, -O-C(O)-NQ628Q629, OP(O)(OQ630)(OQ631), -OSi(Q632)(Q633)(Q634), -OS(O 2 )-Q635, NHC(O)-Q636, -NQ637C(O)-Q638, -NH-C(O)-O-Q639, -NH C(O)-NH-Q640, -NH-C(O)-NQ641Q642, -NQ643-C(O)-O-Q644, 15 NQ645-C(O)-NH-Q646, -NQ647-C(O)-NQ648Q649, -NHS(0 2 ) Q650, -NQ651S(0 2 )-Q652, -S-Q653, -S(O)-Q654, -S(0 2 )-Q655, S(0 2 )NH-Q656, -S(0 2 )NQ657Q658, -S(0 2 )O-Q659, P(O)(OQ660)(OQ661), -Si(Q662)(Q663)(Q664)"; where Q613, Q614, Q615, Q616, Q617, Q618, Q619, Q620, 0621, 20 Q622, Q623, Q624, Q625, Q626, Q627, Q628, Q629, Q630, Q631, Q632, Q633, Q634, Q635, Q636, Q637, Q638, Q639, Q640, Q641, Q642, Q643, Q644, Q645, Q646, Q647, Q648, Q649, Q650, Q651, Q652, Q653, Q654, Q655, Q656, Q657, Q658, Q659, Q660, Q661, Q662, Q663, Q664 are each independently selected from the group 25 consisting of: "alkyl,. (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q619, Q620 and/or Q628, Q629 and/or Q641, Q642 and/or Q648, Q649 and/or Q657, Q658, in each case together, may also form "heterocyclyl"; 30 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP20061068322 -379 (ii) "alkyl, (Cg-C 3 o)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ665, -NQ666Q667, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 5 -SO 3 H, -P(O)(OH) 2 , -C(O)-Q668, -C(O)O-Q669, -C(O)NH Q670, -C(O)NQ671 Q672, -O-Q673, -O(-Q674-0)d-H (d = 1, 2, 3, 4, 5), -O(-Q67 5 -O)d-Q 676 (d = 1, 2, 3, 4, 5), -OC(O)-Q677, OC(O)-O-Q678, -OC(O)-NHQ679, -O-C(O)-NQ680Q681, OP(O)(OQ682)(OQ683), -OSi(Q684)(Q685)(Q686), -OS(0 2 ) 10 Q687, -NHC(O)-Q688, -NQ689C(O)-Q690, -NH-C(O)-O-Q691, -NH-C(O)-NH-Q692, -NH-C(O)-NQ693Q694, -NQ695-C(O) O-Q696, -NQ697-C(O)-NH-Q698, -NQ699-C(O)-NQ700Q701, -NHS(0 2 )-Q702, -NQ703S(0 2 )-Q704, -S-Q705, -S(O)-Q706, S(0 2 )-Q707, -S(0 2 )NH-Q708, -S(0 2 )NQ709Q710, -S(0 2 )O 15 Q711, -P(O)(O712)(OQ713), -Si(Q714)(Q715)(Q716)"; where 0665, Q666, Q667, Q668, Q669, Q670, 0671, Q672, Q673, Q674, Q675, Q676, Q677, Q678, Q679, Q680, Q681, Q682, Q683, Q684, Q685, Q686, Q687, Q688, Q689, Q690, Q691, Q692, Q693, Q694, Q695, Q696, Q697, Q698, Q699, 20 Q700, Q701, Q702, Q703, Q704, Q705, Q706, Q707, Q708, Q709, Q710, Q711, Q712, Q713, Q714, Q715, Q716 are each independently selected from the group consisting of: "alkyl, (Cq C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 25 Q671, Q672 and/or Q680, Q681 and/or Q693, Q694 and/or Q700, Q701 and/or Q709, Q710, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 30 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ717, -NQ718Q719, -NO 2 , - W02007/054556 PCT/EP2006/068322 - 380 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q720, -C(O)O-Q721, C(O)NH-Q722, -C(O)NQ723Q724, -O-Q725, -O(-Q726 O).-H (e = 1, 2, 3, 4, 5), -0(-Q727-0)e-Q728 (e = 1, 2, 3, 4, 5 5), -OC(O)-Q729, -OC(O)-O-Q730, -OC(O)-NHQ731, -0 C(O)-NQ732Q733, -OP(O)(OQ734)(OQ735), OSi(Q736)(Q737)(Q738), -OS(0 2 )-Q739, -NHC(O)-Q740, NQ741C(O)-Q742, -NH-C(O)-O-Q743, -NH-C(O)-NH Q744, -NH-C(O)-NQ745Q746, -NQ747-C(O)-O-Q748, 10 NQ749-C(O)-NH-Q750, -NQ751-C(O)-NQ752Q753, NHS(0 2 )-Q754, -NQ755S(0 2 )-Q756, -S-Q757, -S(O)-Q758, -S(0 2 )-Q759, -S(0 2 )NH-Q760, -S(0 2 )NQ761Q762, S(0 2 )O-Q763, -P(O)(OQ764)(OQ765), Si(Q766)(Q767)(Q768)"; 15 where Q717, Q718, Q719, Q720, Q721, Q722, Q723, Q724, Q725, Q726, Q727, Q728, Q729, Q730, Q731, Q732, Q733, Q734, Q735, Q736, Q737, Q738, Q739, Q740, Q741, Q742, Q743, Q744, Q745, Q746, Q747, Q748, Q749, Q750, Q751, Q752, Q753, Q754, Q755, Q756, Q757, Q758, Q759, Q760, 20 Q761, Q762, Q763, Q764, Q765, Q766, Q767, Q768 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q723, Q724 and/or Q732, Q733 and/or 25 Q745, Q746 and/or Q752, Q753 and/or Q761, Q762, in each case together, may also form "heterocyclyl"; (h) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl radical may be substituted by at least one substituent selected identically 30 or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ769, -NQ770Q771, -NO 2 , -OH, -OCF 3 , - W02007/054556 PCT/EP2006/068322 - 381 SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Q772, -C(O)O-Q773, -C(0)NH-Q774, C(O)NQ775Q776, -O-Q777, -0(-Q778-O)r-H (f = 1, 2, 3, 4, 5), -0( Q779-O)r-Q780 (f = 1, 2, 3, 4, 5), -OC(O)-Q781, -OC(O)-O-Q782, 5 OC(O)-NHQ783, -O-C(O)-NQ784Q785, -OP(O)(OQ786)(OQ787), OSi(Q788)(Q789)(Q790), -OS(0 2 )-Q791, -NHC(O)-Q792, NQ793C(O)-Q794, -NH-C(O)-0-Q795, -NH-C(O)-NH-Q796, NH-C(O)-NQ797Q798, -NQ799-C(O)-0-Q800, -NQ801-C(O)-NH Q802, -NQ803-C(O)-NQ804Q805, -NHS(0 2 )-Q806, -NQ807S(0 2 ) 10 0808, -S-Q809, -S(O)-Q810, -S(0 2 )-Q811, -S(0 2 )NH-Q812, S(0 2 )NQ813Q814, -S(0 2 )O-Q815, -P(O)(OQ816)(OQ817), Si(Q818)(Q819)(0820)"; where Q769, Q770, Q771, Q772, Q773, Q774, Q775, Q776, 0777, Q778, Q779, Q780, Q781, Q782, Q783, Q784, Q785, Q786, Q787, 15 Q788, Q789, Q790, Q791, Q792, Q793, Q794, Q795, Q796, Q797, Q798, Q799, Q800, Q801, Q802, Q803, Q804, 0805, 0806, Q807, Q808, Q809, Q810, Q811, Q812, Q813, Q814, Q815, Q816, Q817, Q818, Q819, Q820 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 20 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q775, Q776 and/or Q784, Q785 and/or Q797, Q798 and/or Q804, Q805 and/or 0813, Q814, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 25 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ821, -NQ822Q823, -NO 2 , -OH, 30 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH)2, -C(O)-Q824, -C(0)0-0825, -C(O)NH Q826, -C(O)NQ827Q828, -O-Q829, -0(-Q830-0)g-H (g = 1, 2, 3, 4, 5), -O(-Q 83 1 -O)g-Q 832 (g = 1, 2, 3, 4, 5), -OC(O)-Q833, OC(O)-O-Q834, -OC(O)-NHQ835, -O-C(O)-NQ836Q837, - W02007/054556 PCT/EP2006/068322 - 382 OP(O)(OQ838)(OQ839), -OSi(Q840)(Q841)(Q842), -OS(0 2 ) Q843, -NHC(O)-Q844, -NQ845C(O)-Q846, -NH-C(O)-O-Q847, -NH-C(O)-NH-Q848, -NH-C(0)-NQ849Q850, -NQ851-C(O) O-Q852, -NQ853-C(O)-NH-Q854, -NQ855-C(O)-NQ856Q857, 5 -NHS(0 2 )-Q858, -NQ859S(0 2 )-Q860, -S-Q861, -S(O)-Q862, S(0 2 )-Q863, -S(0 2 )NH-Q864, -S(0 2 )NQ865Q866, -S(0 2 )O Q867, -P(O)(OQ868)(OQ869), -Si(Q870)(Q871)(Q872)"; where Q821, Q822, Q823, Q824, Q825, Q826, Q827, Q828, Q829, Q830, Q831, Q832, Q833, Q834, Q835, Q836, Q837, 10 Q838, 0839, Q840, Q841, Q842, Q843, Q844, Q845, Q846, 0847, 0848, Q849, Q850, Q851, Q852, Q853, Q854, Q855, Q856, Q857, Q858, Q859, Q860, Q861, 0862, Q863, 0864, Q865, 0866, Q867, Q868, Q869, Q870, Q871, Q872 are each independently selected from the group consisting of: "alkyl, (Cg 15 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q827, Q828 and/or Q836, Q837 and/or Q849, Q850 and/or Q856, Q857 and/or 0865, Q866, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ873, -NQ874Q875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-0876, -C(O)O-Q877, C(O)NH-Q878, -C(O)NQ879Q880, -O-Q881, -O(-Q882 30 O)h-H (h = 1, 2, 3, 4, 5), -O(-Q 8 8 3 -O)h-Q 8 84 (h = 1, 2, 3, 4, 5), -OC(O)-Q885, -OC(O)-O-Q886, -OC(O)-NHQ887, -0 C(O)-NQ888Q889, -OP(O)(OQ890)(OQ891), OSi(Q892)(Q893)(Q894), -OS(0 2 )-Q895, -NHC(O)-Q896, NQ897C(O)-Q898, -NH-C(O)-O-Q899, -NH-C(O)-NH- W02007/054556 PCT/EP20061068322 - 383 Q900, -NH-C(O)-NQ9O1Q902, -NQ903-C(O)-O-Q904, NQ905-C(O)-NH-Q906, -NQ907-C(O)-NQ908Q909, NHS(0 2 )-Q91 0, -NQ91 1 S(0 2 )-Q912, -S-Q913, -S(O)-Q914, -S(0 2 )-Q915, -S(0 2 )NH-Q916, -S(0 2 )NQ917Q918, 5 S(0 2 )O-Q919, -P(O)(OQ920)(OQ921), Si(Q922)(Q923)(Q924)"; where Q873, Q874, Q875, Q876, Q877, 0878, Q879, Q880, Q881, Q882, Q883, Q884, Q885, Q886, Q887, Q888, Q889, Q890, Q891, Q892, Q893, Q894, Q895, Q896, Q897, Q898, 10 Q899, Q900, Q901, Q902, Q903, Q904, Q905, Q906, Q907, Q908, Q909, Q910, Q911, Q912, Q913, Q914, Q915, Q916, Q917, Q918, Q919, Q920, Q921, Q922, Q923, Q924 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q879, Q880 and/or 0888, Q889 and/or Q901, Q902 and/or Q908, Q909 and/or Q917, Q918, in each case together, may also form "heterocyclyl" 20 (j) OZ6 where Z6 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 25 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ925, -NQ926Q927, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 30 -SO 3 H, -P(O)(OH) 2 , -C(O)-Q928, -C(0)O-Q929, -C(O)NH Q930, -C(O)NQ931Q932, -O-Q933, -O(-Q934-O)r-H (i = 1, 2, 3, 4, 5), -0(- 0 935 -O)r-Q 936 (i = 1, 2, 3, 4, 5), -OC(O)-Q937, OC(O)-O-Q938, -OC(O)-NHQ939, -O-C(O)-NQ940Q941, - W02007/054556 PCT/EP2006/068322 -384 OP(O)(OQ942)(OQ943), -OSi(Q944)(Q945)(Q946), -OS(0 2 ) Q947, -NHC(O)-Q948, -NQ949C(O)-Q950, -NH-C(O)-O-Q951, -NH-C(O)-NH-Q952, -NH-C(O)-NQ953Q954, -NQ955-C(O) 0-0956, -NQ957-C(O)-NH-Q958, -NQ959-C(O)-NQ960Q961, 5 -NHS(0 2 )-Q962, -NQ963S(0 2 )-Q964, -S-Q965, -S(O)-Q966, S(0 2 )-Q967, -S(0 2 )NH-Q968, -S(0 2 )NQ969Q970, -S(0 2 )O Q971, -P(O)(OQ972)(OQ973), -Si(Q974)(Q975)(Q976)"; where Q925, Q926, Q927, Q928, Q929, Q930, Q931, Q932, Q933, Q934, Q935, Q936, Q937, Q938, Q939, Q940, Q941, 10 Q942, Q943, Q944, Q945, 0946, Q947, Q948, Q949, Q950, Q951, Q952, Q953, Q954, Q955, Q956, Q957, Q958, Q959, Q960, Q961, Q962, Q963, Q964, Q965, Q966, Q967, Q968, Q969, Q970, Q971, Q972, Q973, Q974, Q975, Q976 are each independently selected from the group consisting of: "alkyl, (C 9 15 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q931, Q932 and/or Q940, Q941 and/or Q953, Q954 and/or Q960, Q961 and/or Q969, Q970, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ977, -NQ978Q979, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q980, -C(O)O-Q981, C(O)NH-Q982, -C(O)NQ983Q984, -O-Q985, -O(-Q986-O); 30 H (j = 1, 2, 3, 4, 5), -O(-Q 9 8 7 -O);-Q 9 8 8 (j = 1, 2, 3, 4, 5), OC(O)-Q989, -OC(O)-O-Q990, -OC(O)-NHQ991, -0-C(O) NQ992Q993, -OP(O)(OQ994)(OQ995), OSi(Q996)(Q997)(Q998), -OS(0 2 )-Q999, -NHC(O)-Q1000, NQ 1001 C(O)-Q1002, -N H-C(O)-O-Q1003, -NH-C(O)-NH- W02007/054556 PCT/EP2006/068322 - 385 Q1004, -NH-C(O)-NQ1005Q1006, -NQ1007-C(O)-O Q1008, -NQ1009-C(O)-NH-Q1010, -NQ101 1-C(O) NQ1012Q1013, -NHS(0 2 )-Q1014, -NQ1015S(O 2 )-Q1016, S-Q1017, -S(O)-Q1018, -S(0 2 )-Q1019, -S(0 2 )NH-Q1020, 5 S(0 2 )NQ1021 Q1022, -S(0 2 )O-Q1023, P(O)(OQ1024)(OQ1025), -Si(Q1 026)(Q1 027)(Q1028)"; where Q977, Q978, Q979, Q980, Q981, Q982, 0983, Q984, Q985, Q986, Q987, Q988, Q989, Q990, Q991, Q992, Q993, Q994, Q995, Q996, Q997, Q998, Q999, Q1000, Q1001, 10 Q1002,Q1003,Q1004, Q1005, Q1006, Q1007, Q1008, Q1009, Q1010, Q1011, Q1012, 01013, Q1014, Q1015, Q1016, Q1017, Q1018,Q1019, Q1020, Q1021, Q1022, Q1023, Q1024, Q1025, Q1026, Q1027, Q1028 are each independently selected from the group consisting of: "alkyl, 15 (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q983, Q984 and/or Q992, Q993 and/or Q1005, Q1006 and/or Q1012, Q1013 and/or Q1021, Q1022, in each case together, may also form "heterocyclyl"; 20 (k) SZ7 where Z7 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 25 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ1029, -NQ1030Q1031, -NO 2 , -OH, 30 -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1032, -C(O)O-Q1033, C(O)NH-Q1034, -C(O)NQ1035Q1036, -O-Q1037, -O(-Q1038 O)k-H (k = 1, 2, 3, 4, 5), -0(-Q1039-O)-Q1040 (k = 1, 2, 3, 4, 5), W02007/054556 PCT/EP2006/068322 - 386 -0C(O)-Q1041, -OC(O)-O-Q1042, -OC(O)-NHQ1043, -0 C(O)-NQ1 044Q1 045, -OP(O)(OQ1 046)(OQ1 047), OSi(Q1048)(Q1049)(Q1050), -OS(0 2 )-Q1051, -NHC(O)-Q1052, -NQ1053C(O)-Q1054, -NH-C(O)-0-Q1055, -NH-C(O)-NH 5 Q1056, -NH-C(O)-NQ1057Q1058, -NQ1059-C(O)-O-Q1060, NQ1061-C(O)-NH-Q1062, -NQ1063-C(O)-NQ1064Q1065, NHS(0 2 )-Q1066, -NQ1067S(0 2 )-Q1068, -S-Q1069, -S(O) Q1070, -S(0 2 )-Q1071, -S(0 2 )NH-Q1072, -S(0 2 )NQ1073Q1074, -S(0 2 )0-Q1075, -P(O)(OQ1076)(OQ1077), 10 Si(Q1078)(Q1079)(Q1080)"; where Q1029, Q1030, Q1031, Q1032, Q1033, Q1034, Q1035, Q1036, Q1037, Q1038, Q1039, Q1040, Q1041, Q1042, Q1043, Q1044, Q1045,Q1046, Q1047, Q1048, Q1049, Q1050, Q1051, Q1052, Q1053, Q1054, Q1055, Q1056, Q1057, Q1058, Q1059, 15 Q1060, Q1061, Q1062, Q1063, Q1064, Q1065, Q1066, Q1067, Q1068, Q1069, Q1070, Q1071, Q1072, Q1073, Q1074, Q1075, Q1076, Q1077, Q1078, Q1079, Q1080 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 20 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1035, Q1036 and/or 01044, Q1045 and/or Q1057, Q1058 and/or Q1064, Q1065 and/or Q1073, Q1074, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) 25 may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 30 CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ1081, -NQ1082Q1083, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1084, C(O)O-Q1085, -C(O)NH-Q1086, -C(O)NQ1 087Q1088, -0 Q1089, -0(-Q1090-0)rH (I = 1, 2, 3, 4, 5), -O(-Q1091-O)r W02007/054556 PCT/EP2006/068322 - 387 Q1092 (I = 1, 2, 3, 4, 5), -OC(O)-Q1093, -OC(O)-O-Q1094, OC(O)-NHQ1095, -0-C(O)-NQ1096Q1097, OP(O)(OQ1098)(OQ1099), -OSi(Q1 100)(Q1 101)(Q1 102), OS(0 2 )-Q1 103, -NHC(O)-Q1 104, -NQ1 105C(O)-Ql 106, 5 NH-C(O)-O-Q1 107, -NH-C(O)-NH-Q1 108, -NH-C(O) NQ1109Q1110, -NQ1111-C(O)-O-Q1112, -NQ1113-C(O) NH-Q1114, -NQ1115-C(O)-NQ1116Q1117, -NHS(0 2 ) Q1118, -NQ1119S(0 2 )-Q1120, -S-Q1121, -S(O)-Q1122, S(0 2 )-Q1 123, -S(0 2 )NH-Q1 124, -S(0 2 )NQ1 125Q1 126, 10 S(0 2 )O-Q1 127, -P(O)(OQ1 128)(OQ1 129), Si(Q1130)(Q1 131)(Q1132)"; where Q1081, Q1082, Q1083, Q1084, Q1085, Q1086, Q1087, Q1088, Q1089, Q1090, Q1091, Q1092, Q1093, Q1094, Q1095, Q1096, Q1097, Q1098, 01099, Q1100, Q1101, 15 Q1102, Q1103, Q1104, Q1105, Q1106, Q1107, Q1108, Q1109, Q1110, Q1111, Q1112, Q1113, Q1114, Q1115, Q1116, Q1117, Q1118, Q1119, Q1120, Q1121, Q1122, Q1123, Q1124, Q1125, Q1126, Q1127, Q1128, Q1129, Q1130, Q1131, Q1132 are each independently selected from 20 the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1087, Q1088 and/or Q1096, Q1097 and/or Q1109, Q1110 and/or Q1116, Q1117 and/or Q1125, Q1126, in each case together, 25 may also form "heterocyclyl"; (1) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) Q1133, -C(0)O-Q1134, -C(O)-NQ1135Q1136, -S(0 2 )-Q1137, S(0 2 )O-Q1 138"; W02007/054556 PCT/EP2006/068322 - 388 where Q1133, Q1134, Q1135, Q1136, 01137, Q1138 are each independently selected from the group consisting of: hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 5 Q1 135, Q1 136 together may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHQ1139, -NQ1140Q1141, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1142, -C(O)O-Q1143, C(O)NH-Q1 144, -C(O)NQ1 145Q1146, -O-Q1147, -O(-Q1148 15 O)m-H (m = 1, 2, 3, 4, 5), -O(-Q1149-)m-Q1150 (m = 1, 2 , 3 , 4, 5), -OC(O)-Ql 151, -OC(O)-O-Q1 152, -OC(O)-NHQ1 153, -0 C(O)-NQ1 154Q1155, -OP(O)(OQ1 156)(OQ1 157), OSi(Q1 158)(Q1 159)(Q1 160), -OS(02)-Qi 161, -NHC(O)-Q1 162, -NQ1 163C(O)-Ql 164, -NH-C(O)-0-Q1 165, -NH-C(O)-NH 20 Q1166, -NH-C(O)-NQ1167Q1168, -NQ1169-C(O)-O-Q1170, NQ1171-C(O)-NH-Q1172, -NQ1173-C(O)-NQ1174Q1175, NHS(0 2 )-Q1 176, -NQ1 177S(02)-Ql 178, -S-Q1179, -S(O) Q1180, -S(0 2 )-Ql 181, -S(0 2 )NH-Q1 182, -S(0 2 )NQ1 183Q1184, -S(02)0-Q1185, -P(O)(OQ1 186)(OQ1 187), 25 Si(Q1 188)(Q1 189)(Q1 190)"; where Q1139, Q1140, Q1141, Q1142, Q1143, Q1144, Q1145, Q1146, Q1147, Q1148, Q1149, Q1150, Q1151, Q1152, Q1153, Q1154, Q1155, Q1156, Q1157, Q1158, Q1159, Q1160, Q1161, Q1162, Q1163, Q1164, Q1165, Q1166, Q1167, Q1168, Q1169, 30 Q1170, Q1171, Q1172, Q1173, Q1174, Q1175, Q1176, Q1177, Q1178, Q1179, Q1180, Q1181, Q1182, Q1183, Q1184, Q1185, Q1186, Q1187, Q1188, Q1189, Q1190 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, W02007/054556 PCT/EP2006/068322 -389 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1145, Q1146 and/or Q1154, Q1155 and/or Q1167, Q1168 and/or Q1 174, Q1 175 and/or Q1 183, Q1 184, in each case together, may also form "heterocyclyl"; 5 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHQ1191, -NQ1192Q1193, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Q1 194, C(O)O-Q1195, -C(O)NH-Q1 196, -C(O)NQ1 197Q1198, -0 15 Q1199, -O(-Q1200-0),-H (n = 1, 2, 3, 4, 5), -0(-Q1201 0),-Q1202 (n = 1, 2, 3, 4, 5), -OC(O)-Q1203, -OC(O)-O Q1204, -OC(O)-NHQ1205, -O-C(O)-NQ1206Q1207, OP(O)(OQ1208)(OQ1209), -OSi(Q1210)(Q1211)(Q1212), OS(02)-Q1213, -NHC(O)-Q1214, -NQ1215C(O)-Q1216, 20 NH-C(O)-O-Q1217, -NH-C(O)-NH-Q1218, -NH-C(O) NQ1219Q1220, -NQ1221-C(O)-O-Q1222, -NQ1223-C(O) NH-Q1224, -NQ1225-C(O)-NQ1226Q1227, -NHS(0 2 ) Q1228, -NQ1229S(0 2 )-Q1230, -S-Q1231, -S(O)-Q1232, S(0 2 )-Q1233, -S(0 2 )NH-Q1234, -S(0 2 )NQ1235Q1236, 25 S(0 2 )O-Q1237, -P(O)(OQ1 238)(OQ1239), Si(Q1 240)(Q1241)(Q1242)"; where Q1191, Q1192, Q1193, Q1194, Q1195, Q1196, Q1197, Q1198, Q1199, Q1200, Q1201, Q1202, Q1203, 01204, Q1205, Q1206, Q1207, Q1208, Q1209, Q1210, Q1211, 30 Q1212, Q1213, Q1214, Q1215, Q1216, Q1217, Q1218, Q1219, Q1220, Q1221, Q1222, Q1223, Q1224, Q1225, Q1226, Q1227, Q1228, Q1229, Q1230, Q1231, Q1232, Q1233, Q1234, Q1235, Q1236, Q1237, Q1238, Q1239, Q1240, Q1241, Q1242 are each independently selected from W02007/054556 PCT/EP2006/068322 - 390 the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, Q1197, Q1 198 and/or Q1206, Q1207 and/or Q1219, Q1220 and/or 5 Q1226, Q1227 and/or Q1235, Q1236, in each case together, may also form "heterocyclyl"; and 10 Z1, Z2 radicals are each independently selected from the group consisting of: "hydrogen, NZ14Z15"; with the proviso that when Z1 = H, Z2 = NZ14Z15, and when Z1 = NZ14Z15, Z2 = H; where Z14, Z15 are each independently selected from the group consisting of: 15 (a) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(Y1)NZ16Z17, C(=NZ18)-Z19, -C(Y2)NZ20-Y3-Z21"; with the proviso that Z14, Z15 are not simultaneously hydrogen or "alkyl, (C 9 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 20 arylalkyl, heteroaryl, heteroarylalkyl"; with the further proviso that when one of the Z1 4, Z1 5 radicals is hydrogen or "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl", the other Z14, Z15 radical in each case is "-C(Y1)NZ16Z1 7", "-C(=NZ18)-Z19" or "-C(Y2)NZ20-Y3-Z21"; 25 where Y1, Y2, Y3 are each independently selected from the group consisting of "0, S, =NH, =NZ22"; where Z16, Z17, Z18, Z19, Z20, Z21, Z22 are each independently selected from the group consisting of: (1) hydrogen 30 (2) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl"; W02007/054556 PCT/EP2006/068322 -391 where the above substituents of substitution group (a) and/or substitution group (2) may optionally each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU1, -NU2U3, -NO 2 , -OH, -OCF 3 , -SH, -0 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U4, -C(O)O-U5, -C(O)NH-U6, -C(O)NU7U8, -O-U9, -O( U1O-0)r-H (r = 1, 2, 3, 4, 5), -O(-U 11-O)r-U12 (r = 1, 2, 3, 4, 5), 10 OC(O)-U13, -OC(O)-O-U14, -OC(O)-NHU15, -O-C(O)-NU16U17, -OP(O)(OU18)(OU19), -OSi(U20)(U21)(U22), -OS(0 2 )-U23, NHC(O)-U24, -NU25C(O)-U26, -NH-C(O)-0-U27, -NH-C(O)-NH U28, -NH-C(O)-NU29U30, -NU31-C(O)-O-U32, -NU33-C(O)-NH U34, -NU35-C(O)-NU36U37, -NHS(0 2 )-U38, -NU39S(0 2 )-U40, 15 S-U41, -S(O)-U42, -S(0 2 )-U43, -S(0 2 )NH-U44, -S(0 2 )NU45U46, S(0 2 )O-U47, -P(O)(OU48)(OU49), -Si(U50)(U51)(U52)"; where U1, U2, U3, U4, US, U6, U7, U8, U9, U10, U11, U12, U13, U14, U15, U16, U17, U18, U19, U20, U21, U22, U23, U24, U25, U26, U27, U28, U29, U30, U31, U32, U33, U34, U35, U36, U37, U38, U39, U40, 20 U41, U42, U43, U44, U45, U46, U47, U48, U49, U50, U51, U52 are each independently selected from the group consisting of: "alkyl, (Cg C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U7, U8 and/or U16, U17 and/or U29, U30 and/or U36, U37 and/or U45, 25 U46, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU53, -NU54U55, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , SO 3 H, -P(O)(OH) 2 , -C(O)-U56, -C(O)O-U57, -C(O)NH-U58, - W02007/054556 PCT/EP2006/068322 - 392 C(O)NU59U60, -O-U61, -O(-U62-O)rH (r = 1, 2, 3, 4, 5), -O( U63-0)rU64 (r = 1, 2, 3, 4, 5), -OC(O)-U65, -OC(O)-O-U66, OC(O)-NHU67, -O-C(O)-NU68U69, -OP(O)(OU70)(OU71), OSi(U72)(U73)(U74), -OS(0 2 )-U75, -NHC(O)-U76, -NU77C(O) 5 U78, -NH-C(O)-O-U79, -NH-C(O)-NH-U80, -NH-C(O) NU81U82, -NU83-C(O)-O-U84, -NU85-C(O)-NH-U86, -NU87 C(O)-NU88U89, -NHS(0 2 )-U90, -NU91S(0 2 )-U92, -S-U93, S(O)-U94, -S(0 2 )-U95, -S(0 2 )NH-U96, -S(0 2 )NU97U98, S(0 2 )O-U99, -P(O)(OU100)(OU101), -Si(U102)(U103)(U104)"; 10 where U53, U54, U55, U56, U57, U58, U59, U60, U61, U62, U63, U64, U65, U66, U67, U68, U69, U70, U71, U72, U73, U74, U75, U76, U77, U78, U79, U80, U81, U82, U83, U84, U85, U86, U87, U88, U89, U90, U91, U92, U93, U94, U95, U96, U97, U98, U99, U100, U101, U102, U103, U104 are each independently selected 15 from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U59, U60 and/or U68, U69 and/or U81, U82 and/or U88, U89 and/or U97, U98, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU105, -NU106U107, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U108, -C(O)O-U109, C(O)NH-U1 10, -C(O)NU1 11U1 12, -O-U-113, -0(-U1 14-0)s 30 H (s = 1, 2, 3, 4, 5), -O(-U115-0)-U116 (s = 1, 2, 3, 4, 5), OC(O)-U 117, -OC(O)-O-U1 18, -OC(O)-NHU119, -0-C(O) NU120U121, -OP(O)(OU122)(OU123), OSi(U124)(U125)(U126), -OS(O 2 )-U127, -NHC(O)-U128, NU 129C(O)-U 130, -NH-C(O)-O-U131, -NH-C(O)-NH- W02007/054556 PCT/EP2006/068322 -393 U132, -NH-C(O)-NU133U134, -NU135-C(O)-O-U136, NU137-C(O)-NH-U138, -NU139-C(O)-NU14OU141, NHS(0 2 )-U142, -NU143S(0 2 )-U144, -S-U145, -S(O)-U146, -S(0 2 )-U147, -S(0 2 )NH-U148, -S(0 2 )NU149U150, -S(02)0 5 U151, -P(O)(OU152)(OU153), -Si(U154)(U155)(U156)"; where U105, U106, U107, U108, U109, U110, U11, U112, U113, U114, U115, U116, U117, U118, U119, U120, U121, U122, U123, U124, U125, U126, U127, U128, U129, U130, U131, U132, U133, U134, U135, U136, U137, U138, U139, 10 U140, U141, U142, U143, U144, U145, U146, U147, U148, U149, U150, U151, U152, U153, U154, U155, U156 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 15 where, alternatively, U111, U112 and/or U120, U121 and/or U133, U134 and/or U140, U141 and/or U149, U150, in each case together, may also form "heterocyclyl"; (3) -C(O)-Z23, where Z23 is independently selected from the group 20 consisting of: (a) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where the above substituents of substitution group (a) may optionally each independently be substituted by at least one substituent selected 25 identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU157, -NU158U159, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 30 -SO 3 H, -P(O)(OH) 2 , -C(O)-U160, -C(0)O-U161, -C(O)NH U162, -C(O)NU163U164, -O-U165, -O(-U166-O)t-H (t = 1, 2, 3, 4, 5), -O(-U167-O)t-U168 (t = 1, 2, 3, 4, 5), -OC(O)-U169, OC(O)-O-U170, -OC(O)-NHU171, -0-C(O)-NU172U173, - W02007/054556 PCT/EP2006/068322 - 394 OP(O)(OU174)(OU175), -OSi(U176)(U177)(U178), -OS(0 2 ) U179, -NHC(O)-U180, -NU181C(O)-U182, -NH-C(O)-O-U183, -NH-C(O)-NH-U184, -NH-C(O)-NU 1 85U 186, -NU 187-C(O) O-U188, -NU189-C(O)-NH-U190, -NU191-C(O)-NU192U193, 5 -NHS(0 2 )-U194, -NU195S(0 2 )-U196, -S-U197, -S(O)-U198, S(0 2 )-U199, -S(0 2 )NH-U200, -S(0 2 )NU2O1U202, -S(02)0 U203, -P(O)(OU204)(OU205), -Si(U206)(U207)(U208)"; where U157, U158, U159, U160, U161, U162, U163, U164, U165, U166, U167, U168, U169, U170, U171, U172, U173, U174, U175, 10 U176, U177, U178, U179, U180, U181, U182, U183, U184, U185, U186, U187, U188, U189, U190, U191, U192, U193, U194, U195, U196, U197, U198, U199, U200, U201, U202, U203, U204, U205, U206, U207, U208 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 15 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U 163, U164 and/or U 172, U173 and/or U185, U186 and/or U192, U193 and/or U201, U202, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) 20 may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 25 CI, Br, !, CN, CF 3 , N 3 , NH 2 , -NHU209, -NU21OU211, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U212, -C(O)O-U213, C(O)NH-U214, -C(O)NU215U216, -O-U217, -O(-U21 8-O)- H (u = 1, 2, 3, 4, 5), -O(-U219-O),-U220 (u = 1, 2, 3, 4, 5), 30 OC(O)-U221, -OC(O)-O-U222, -OC(O)-NHU223, -0-C(O) NU224U225, -OP(O)(OU226)(OU227), OSi(U228)(U229)(U230), -OS(0 2 )-U231, -NHC(O)-U232, NU233C(O)-U234, -NH-C(O)-O-U235, -NH-C(O)-NH U236, -NH-C(O)-NU237U238, -NU239-C(O)-O-U240, - W02007/054556 PCT/EP2006/068322 - 395 NU241-C(O)-NH-U242, -NU243-C(O)-NU244U245, NHS(0 2 )-U246, -NU247S(0 2 )-U248, -S-U249, -S(O)-U250, -S(0 2 )-U251, -S(0 2 )NH-U252, -S(0 2 )NU253U254, -S(0 2 )O U255, -P(O)(OU256)(OU257), -Si(U258)(U259)(U260)"; 5 where U209, U210, U211, U212, U213, U214, U215, U216, U217, U218, U219, U220, U221, U222, U223, U224, U225, U226, U227, U228, U229, U230, U231, U232, U233, U234, U235, U236, U237, U238, U239, U240,U241, U242, U243, U244, U245, U246, U247, U248, U249, U250, U251, U252, 10 U253, U254, U255, U256, U257, U258, U259, U260 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U215, U216 and/or U224, U225 and/or 15 U237, U238 and/or U244, U245 and/or U253, U254, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the 20 group consisting of: (iii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU261, -NU262U263, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, 25 -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U264, C(O)O-U265, -C(O)NH-U266, -C(O)NU267U268, -0 U269, -O(-U270-O)v-H (v = 1, 2, 3, 4, 5), -O(-U271-O)V U272 (v = 1, 2, 3, 4, 5), -OC(O)-U273, -OC(O)-O-U274, -OC(O)-NHU275, -O-C(O)-NU276U277, 30 OP(O)(OU278)(OU279), -OSi(U280)(U281)(U282), OS(0 2 )-U283, -NHC(O)-U284, -NU285C(O)-U286, -NH C(O)-O-U287, -NH-C(O)-NH-U288, -NH-C(O) NU289U290, -NU291-C(O)-O-U292, -NU293-C(O)-NH U294, -NU295-C(O)-NU296U297, -NHS(0 2 )-U298, - W02007/054556 PCT/EP2006/068322 -396 NU299S(O 2 )-U300, -S-U301, -S(O)-U302, -S(0 2 )-U303, -S(0 2 )NH-U304, -S(0 2 )NU305U306, -S(0 2 )O-U307, P(O)(OU308)(OU309), -Si(U310)(U31 1)(U312)"; where U261, U262, U263, U264, U265, U266, U267, U268, 5 U269, U270, U271, U272, U273, U274, U275, U276, U277, U278, U279, U280, U281, U282, U283, U284, U285, U286, U287, U288, U289, U290, U291, U292, U293, U294, U295, U296, U297, U298, U299, U300, U301, U302, U303, U304, U305, U306, U307, U308, U309, U310, U311, U312 are 10 each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U267, U268 and/or U276, U277 and/or U289, U290 and/or U296, U297 and/or U305, U306, 15 in each case together, may also form "heterocyclyl"; (4) Z16, Z17 may independently optionally also form "heterocyclyl" together; (5) "-C(O)-C(O)-U313, -S(0 2 )-NU314U315"; 20 where U313, U314, U315 are each independently selected from the group consisting of: (J) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHU316, 25 NU317U318, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U319, C(O)O-U320, -C(O)NH-U321, -C(O)NU322U323, -O-U324, -O( U325-O)w-H (w = 1, 2, 3, 4, 5), -O(-U326-O).-U327 (w = 1, 2, 3, 4, 5), -OC(O)-U328, -OC(O)-O-U329, -OC(O)-NHU330, -0 30 C(O)-NU331U332, -OP(O)(OU333)(OU334), OSi(U335)(U336)(U337), -OS(0 2 )-U338, -NHC(O)-U339, NU340C(O)-U341, -NH-C(O)-O-U342, -NH-C(O)-NH-U343, NH-C(O)-NU344U345, -NU346-C(O)-O-U347, -NU348-C(O)- W02007/054556 PCT/EP2006/068322 .-397 NH-U349, -NU350-C(O)-NU351U352, -NHS(0 2 )-U353, NU354S(0 2 )-U355, -S-U356, -S(O)-U357, -S(O 2 )-U358, S(0 2 )NH-U359, -S(0 2 )NU360U361, -S(0 2 )O-U362, P(O)(OU363)(OU364), -Si(U365)(U366)(U367)"; 5 where U316, U317, U318, U319, U320, U321, U322, U323, U324, U325, U326, U327, U328, U329, U330, U331, U332, U333, U334, U335, U336, U337, U338, U339, U340, U341, U342, U343, U344, U345, U346, U347, U348, U349, U350, U351, U352, U353, U354, U355, U356, U357, U358, U359, U360, U361, U362, U363, U364, 10 U365, U366, U367 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U322, U323 and/or U331, U332 and/or U344, U345 and/or U351, U352 and/or U360, U361, in 15 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substitution group (I) may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 20 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU368, -NU369U370, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U371, -C(O)O-U372, 25 C(O)NH-U373, -C(O)NU374U375, -O-U376, -O(-U377-O).-H (x = 1, 2, 3, 4, 5), -O(-U378-O),-U379 (x = 1, 2, 3, 4, 5), OC(O)-U380, -OC(O)-O-U381, -OC(O)-NHU382, -0-C(0) NU383U384, -OP(O)(OU385)(OU386), OSi(U387)(U388)(U389), -OS(0 2 )-U390, -NHC(O)-U391, 30 NU392C(O)-U393, -NH-C(O)-O-U394, -NH-C(O)-NH-U395, -NH-C(O)-NU396U397, -NU398-C(O)-O-U399, -NU400 C(O)-NH-U401, -NU402-C(O)-NU403U404, -NHS(0 2 )-U405, -NU406S(0 2 )-U407, -S-U408, -S(O)-U409, -S(0 2 )-U41 0, - W02007/054556 PCT/EP2006/068322 - 398 S(0 2 )NH-U41 1, -S(0 2 )NU412U413, -S(0 2 )O-U414, P(O)(OU415)(OU416), -Si(U417)(U418)(U419)"; where U368, U369, U370, U371, U372, U373, U374, U375, U376, U377, U378, U379, U380, U381, U382, U383, U384, 5 U385, U386, U387, U388, U389, U390, U391, U392, U393, U394, U395, U396, U397, U398, U399, U400, U401, U402, U403, U404, U405, U406, U407, U408, U409, U410, U411, U412, U413, U414, U415, U416, U417, U418, U419 are each independently selected from the group consisting of: "alkyl, (C9 10 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U374, U375 and/or U383, U384 and/or U396, U397 and/or U403, U404 and/or U412, U413, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 20 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU420, -NU421U422, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-U423, C(O)O-U424, -C(O)NH-U425, -C(O)NU426U427, -0 25 U428, -O(-U429-O)y-H (y = 1, 2, 3, 4, 5), -O(-U430-O)y U431 (y = 1, 2, 3, 4, 5), -OC(O)-U432, -OC(O)-O-U433, OC(O)-NHU434, -O-C(O)-NU435U436, OP(O)(OU437)(OU438), -OSi(U439)(U440)(U441), OS(0 2 )-U442, -NHC(O)-U443, -NU444C(O)-U445, -NH 30 C(O)-O-U446, -NH-C(O)-NH-U447, -NH-C(O) NU448U449, -NU450-C(O)-O-U451, -NU452-C(O)-NH U453, -NU454-C(O)-NU455U456, -NHS(0 2 )-U457, NU458S(0 2 )-U459, -S-U460, -S(O)-U461, -S(0 2 )-U462, - W02007/054556 PCT/EP2006/068322 - 399 S(0 2 )NH-U463, -S(0 2 )NU464U465, -S(0 2 )O-U466, P(O)(OU467)(OU468), -Si(U469)(U470)(U471)"; where U420, U421, U422, U423, U424, U425, U426, U427, U428, U429, U430, U431, U432, U433, U434, U435, U436, 5 U437, U438, U439, U440, U441, U442, U443, U444, U445, U446, U447, U448, U449, U450, U451, U452, U453, U454, U455, U456, U457, U458, U459, U460, U461, U462, U463, U464, U465, U466, U467, U468, U469, U470, U471 are each independently selected from the group consisting of: "alkyl, 10 (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U426, U427 and/or U435, U436 and/or U448, U449 and/or U455, U456 and/or U464, U465, in each case together, may also form "heterocyclyl"; 15 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C9-C 3 0)alkyl, cycloalkyl, cycloalkylalkyl, 20 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHU472, -NU473U474, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH)2, -C(O)-U475, -C(O)O-U476, -C(O)NH 25 U477, -C(O)NU478U479, -O-U480, -O(-U481-0)z-H (z = 1, 2, 3, 4, 5), -O(-U482-O),-U483 (z = 1, 2, 3, 4, 5), OC(O)-U484, -OC(O)-O-U485, -OC(O)-NHU486, -0 C(O)-NU487U488, -OP(O)(OU489)(OU490), OSi(U491)(U492)(U493), -OS(0 2 )-U494, -NHC(O) 30 U495, -NU496C(O)-U497, -NH-C(O)-O-U498, -NH C(O)-NH-U499, -NH-C(O)-NU500U501, -NU502 C(O)-0-U503, -NU504-C(O)-NH-U505, -NU506 C(O)-NU507U508, -NHS(0 2 )-U509, -NU51OS(0 2 ) U511, -S-U512, -S(O)-U513, -S(0 2 )-U514, -S(0 2 )NH- W02007/054556 PCT/EP2006/068322 -400 U515, -S(0 2 )NU516U517, -S(0 2 )O-U518, P(O)(OU519)(OU520), -Si(U521)(U522)(U523)"; where U472, U473, U474, U475, U476, U477, U478, U479, U480, U481, U482, U483, U484, U485, U486, 5 U487, U488, U489, U490, U491, U492, U493, U494, U495, U496, U497, U498, U499, U500, U501, U502, U503, U504, U505, U506, U507, U508, U509, U510, U511, U512, U513, U514, U515, U516, U517, U518, U519, U520, U521, U522, U523 are each independently 10 selected from the group consisting of: "alkyl, (C C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, U478, U479 and/or U487, U488 and/or U500, U501 and/or U507, 15 U508 and/or U516, U517, in each case together, may also form "heterocyclyl"; and where, alternatively, U314, U315 together may also form "heterocyclyl"; 20 and the Z5 radical is independently selected from the group consisting of: (i) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, 25 CF 3 , N 3 , NH 2 , -NHA1, -NA2A3, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-A4, C(O)O-A5, -C(O)NH-A6, -C(O)NA7A8, -O-A9, -O(-A1O-O)r-H (r = 1, 2, 3, 4, 5), -O(-A11-0)r-A12 (r = 1, 2, 3, 4, 5), -OC(O)-A13, -OC(O)-O-A14, OC(O)-N HA1 5, -O-C(O)-NA1 6A1 7, -OP(O)(OA1 8)(OA1 9), 30 OSi(A20)(A21)(A22), -OS(O 2 )-A23, -NHC(O)-A24, -NA25C(O)-A26, -NH C(O)-O-A27, -NH-C(O)-NH-A28, -NH-C(O)-NA29A30, -NA31-C(O)-O A32, -NA33-C(O)-NH-A34, -NA35-C(O)-NA36A37, -NHS(0 2 )-A38, - W02007/054556 PCT/EP2006/068322 -401 NA39S(0 2 )-A40, -S-A41, -S(O)-A42, -S(0 2 )-A43, -S(O 2 )NH-A44, S(0 2 )NA45A46, -S(0 2 )O-A47, -P(O)(OA48)(OA49), -Si(A50)(A51)(A52)"; where Al, A2, A3, A4, A5, A6, A7, A8, A9, Al0, Al1, A12, A13, A14, A15, A16, A17, A18, A19, A20, A21, A22, A23, A24, A25, A26, A27, A28, A29, 5 A30, A31, A32, A33, A34, A35, A36, A37, A38, A39, A40, A41, A42, A43, A44, A45, A46, A47, A48, A49, A50, A51, A52 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, A7, A8 and/or A16, A17 and/or A29, 10 A30 and/or A36, A37 and/or A45, A46, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (ii) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHA53, -NA54A55, -NO 2 , -OH, -OCF 3 , -SH, -0 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-A56, -C(O)O-A57, -C(O)NH-A58, -C(O)NA59A60, -0-A61, -O( 20 A62-0),-H (s = 1, 2, 3, 4, 5), -0(-A63-O)t-A64 (t = 1, 2, 3, 4, 5), OC(O)-A65, -OC(O)-O-A66, -OC(O)-NHA67, -O-C(O)-NA68A69, OP(O)(OA70)(OA71), -OSi(A72)(A73)(A74), -OS(0 2 )-A75, -NHC(O) A76, -NA77C(O)-A78, -NH-C(O)-O-A79, -NH-C(O)-NH-A80, -NH C(O)-NA81A82, -NA83-C(O)-O-A84, -NA85-C(O)-NH-A86, -NA87 25 C(O)-NA88A89, -NHS(0 2 )-A90, -NA91S(0 2 )-A92, -S-A93, -S(O)-A94, -S(0 2 )-A95, -S(0 2 )NH-A96, -S(0 2 )NA97A98, -S(0 2 )O-A99, P(O)(OA1 00)(OA1 01), -Si(Al 02)(A1 03)(A1 04)"; where A53, A54, A55, A56, A57, A58, A59, A60, A61, A62, A63, A64, A65, A66, A67, A68, A69, A70, A71, A72, A73, A74, A75, A76, A77, A78, 30 A79, A80, A81, A82, A83, A84, A85, A86, A87, A88, A89, A90, A91, A92, A93, A94, A95, A96, A97, A98, A99, A100, A101, A102, A103, A104 are each independently selected from the group consisting of: "alkyl, (Ce C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, W02007/054556 PCT/EP2006/068322 -402 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, A59, A60 and/or A68, A69 and/or A81, A82 and/or A88, A89 and/or A97, A98, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in 5 turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHA105, -NA106A107, -NO 2 , -OH, -OCF 3 , -SH, 10 -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Al 08, -C(O)O-Al 09, -C(O)NH-Al 10, C(O)NA111All2, -O-A113, -0(-Al14-0)t-H (t = 1, 2, 3, 4, 5), -O( Al115-O)t-Al 16 (t = 1, 2, 3, 4, 5), -OC(O)-Al 17, -OC(O)-O-Al 18, OC(O)-NHA1 19, -O-C(O)-NA1 20A1 21, -OP(O)(OA122)(OA1 23), 15 OSi(A124)(A125)(A126), -OS(O 2 )-A127, -NHC(O)-Al28, NA129C(O)-A130, -NH-C(O)-O-A131, -NH-C(O)-NH-Al32, -NH C(O)-NA1 33A1 34, -NA1 35-C(O)-O-Al 36, -NA1 37-C(O)-NH A138, -NA139-C(O)-NA140A141, -NHS(0 2 )-A142, -NA143S(0 2 ) A144, -S-A145, -S(O)-A146, -S(0 2 )-A147, -S(0 2 )NH-A148, 20 S(0 2 )NA149A1 50, -S(0 2 )O-Al 51, -P(O)(OA1 52)(OA1 53), Si(Al 54)(Al 55)(Al 56)"; where A105, A106, A107, A108, A109, A110, A111, A112, A113, A114, All5, A116, A117, A118, A119, A120, A121, A122, A123, A124, A125,A126, A127, A128, A129, A130, A131, A132, A133, 25 A134, A135,A136, A137, A138, A139, A140, A141, A142, A143, A144, A145,A146, A147, A148, A149, Al5O, A151, A152, A153, A154, A155, A156 are each independently selected from the group consisting of: "alkyl, (CO-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 30 heteroarylalkyl" and where, alternatively, Al 11, Al 12 and/or A120, A121 and/or A133, A134 and/or A140, A141 and/or A149, A150, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 403 or (E) one of the Z1, Z2 radicals or both Z1, Z2 radicals are each independently selected from the group consisting of: 5 (a) -NZ24Z25; with the proviso that one of the Z24, Z25 radicals or both Z24, Z25 radicals are each independently selected from the group consisting of: (1) "-C(O)-C(O)-Tl, -S(0 2 )-NT2T3"; where T1, T2, T3 are each independently selected from the group 10 consisting of: (J) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT4, -NT5T6, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 15 -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T7, -C(O)O-T8, -C(O)NH T9, -C(O)NT1OT11, -O-T12, -O(-T13-O)p-H (p = 1, 2, 3, 4, 5), O(-T14-O)p-T15 (p = 1, 2, 3, 4, 5), -OC(O)-T16, -OC(O)-O-T17, OC(O)-NHT18, -0-C(O)-NT19T20, -OP(O)(OT21)(OT22), OSi(T23)(T24)(T25), -OS(0 2 )-T26, -NHC(O)-T27, -NT28C(O) 20 T29, -NH-C(O)-O-T30, -NH-C(O)-NH-T31, -NH-C(O)-NT32T33, -NT34-C(O)-O-T35, -NT36-C(O)-NH-T37, -NT38-C(O) NT39T40, -NHS(0 2 )-T41, -NT42S(0 2 )-T43, -S-T44, -S(O)-T45, S(0 2 )-T46, -S(0 2 )NH-T47, -S(0 2 )NT48T49, -S(0 2 )O-T50, P(O)(OT51)(OT52), -Si(T53)(T54)(T55)"; 25 where T4, T5, T6, T7, T8, T9, T10, T1 1, T12, T13, T14, T15, T16, T17, T18, T19, T20, T21, T22, T23, T24, T25, T26, T27, T28, T29, T30, T31, T32, T33, T34, T35, T36, T37, T38, T39, T40, T41, T42, T43, T44, T45, T46, T47, T48,T49, T50, T51, T52, T53, T54, T55 are each independently selected from the group consisting of: "alkyl, 30 (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 0, T1 1 and/or T1 9, T20 and/or T32, T33 W02007/054556 PCT/EP2006/068322 -404 and/or T39, T40 and/or T48, T49, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substitution group (I) may each independently be further substituted by at least one 5 substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT56, -NT57T58, -NO 2 , -OH, 10 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T59, -C(O)O-T60, C(O)NH-T61, -C(O)NT62T63, -O-T64, -O(-T65-O)r-H (r = 1, 2, 3, 4, 5), -O(-T66-O)r-T67 (r = 1, 2, 3, 4, 5), -OC(O)-T68, OC(O)-O-T69, -OC(O)-NHT70, -O-C(O)-NT71T72, 15 OP(O)(OT73)(OT74), -OSi(T75)(T76)(T77), -OS(0 2 )-T78, NHC(O)-T79, -NT80C(O)-T81, -NH-C(O)-O-T82, -NH-C(O) NH-T83, -NH-C(O)-NT84T85, -NT86-C(O)-O-T87, -NT88 C(O)-NH-T89, -NT90-C(O)-NT91T92, -NHS(O 2 )-T93, NT94S(0 2 )-T95, -S-T96, -S(O)-T97, -S(0 2 )-T98, -S(0 2 )NH 20 T99, -S(O 2 )NT100T101, -S(O 2 )O-T102, -P(O)(OT103)(OT104), -Si(T1 05)(T1 06)(T1 07)"; where T56, T57, T58, T59, T60, T61, T62, T63, T64, T65, T66, T67, T68, T69, T70, T71, T72, T73, T74, T75, T76, T77, T78, T79, T80, T81, T82, T83, T84, T85, T86,T87, T88, T89, T90, 25 T91,T92, T93, T94, T95, T96, T97, T98,T99, T1O, T1Ol, T102, T103, T104, T105, T106, T107 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T62, T63 30 and/or T71, T72 and/or T84, T85 and/or T91, T92 and/or T1 00, T101, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one W02007/054556 PCT/EP2006/068322 -405 substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 5 Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT108, -NT109T110, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T11, -C(O)O-T112, -C(O)NH-T113, -C(O)NT114T115, -O-T116, -O(-T117 O),-H (s = 1, 2, 3, 4, 5), -O(-Tl 18-0) 5 -T1 19 (s = 1, 2, 3, 4, 10 5), -OC(O)-T120, -OC(O)-O-T121, -OC(O)-NHT122, -0 C(O)-NT1 23T1 24, -OP(O)(OT1 25)(OT1 26), OSi(T127)(T128)(T129), -OS(O 2 )-T130, -NHC(O)-T131, NT132C(O)-T133, -NH-C(O)-O-T134, -NH-C(O)-NH T1 35, -NH-C(O)-NT1 36T1 37, -NT1 38-C(O)-O-T1 39, 15 NT140-C(O)-NH-T141, -NT142-C(O)-NT143T144, NHS(0 2 )-T145, -NT146S(0 2 )-T147, -S-T148, -S(O)-T149, -S(0 2 )-T1 50, -S(0 2 )NH-T1 51, -S(0 2 )NT1 52T1 53, S(0 2 )O-T1 54, -P(O)(OT1 55)(OT1 56), Si(T1 57)(T1 58)(T1 59)"; 20 where T108, T109, T110, T111, T112, T113, T114, T115, T116, T117, T118, Tii9, T12O, T121, T122, T123, T124, T125, T126, T127, T128, T129, T13O, T131, T132, Ti33, T134, T135, T136, T137, T138, T139, T140, T141, T142, T143,T144, T145, T146, T147, T148, T149, T15O, Ti51, 25 T152, T153, T154, T155, T156, T157, T158, T159 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 14, T1 15 and/or T123, T1 24 30 and/or T136, T137 and/or T143, T144 and/or T152, T153, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least W02007/054556 PCT/EP2006/068322 -406 one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 5 heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT160, -NT161T162, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T163, -C(O)O-T164, -C(O)NH-T165, -C(O)NT166T167, -O-T168, -O(-T169-O)t-H (t = 1, 2, 10 3, 4, 5), -O(-T170-O)t-T171 (t = 1, 2, 3, 4, 5), -OC(O) T172, -OC(O)-O-T173, -OC(O)-NHT174, -0-C(O) NT175T176, -OP(O)(OT177)(OTI 78), OSi(T1 79)(T1 80)(T1 81), -OS(0 2 )-T1 82, -NHC(O)-T1 83, -NT184C(O)-T185, -NH-C(O)-0-Ti86, -NH-C(O) 15 NH-T187, -NH-C(O)-NT188T189, -NT190-C(O)-O T191, -NT192-C(O)-NH-T193, -NT194-C(O) NT195T196, -NHS(0 2 )-T197, -NT198S(0 2 )-T199, -S T200, -S(O)-T201, -S(0 2 )-T202, -S(0 2 )NH-T203, S(0 2 )NT204T205, -S(0 2 )O-T206, 20 P(O)(OT207)(OT208), -Si(T209)(T210)(T21 1)"; where T160, T161, T162, T163, T164, T165, T166, T167, T168, T169, T170, T171, T172, T173, T174, T175, T176, T177, T178, T179, T180, T181, T182, T183, T184, T185, T186, T187, T188, T189, T190, T191, T192, T193, T194, 25 T195, T196, T197, T198, T199, T200, T201, T202, T203, T204, T205, T206, T207, T208, T209, T210, T211 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 30 heteroarylalkyl" and where, alternatively, T166, T167 and/or T175, T176 and/or T188, T189 and/or T195, T196 and/or T204, T205, in each case together, may also form "heterocycly"; where, alternatively, T2, T3 together may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 407 and one of the Z24, Z25 radicals or neither of the Z24, Z25 radicals is also independently selected from the group consisting of: (2) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 5 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substitution group (2) may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 10 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT212, -NT213T214, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T215, -C(O)O-T216, -C(O)NH-T217, C(O)NT218T219, -O-T220, -O(-T221-0),-H (u = 1, 2, 3, 4, 5), 15 O(-T222-O)--T223 (u = 1, 2, 3, 4, 5), -OC(O)-T224, -OC(O)-O T225, -OC(O)-NHT226, -O-C(O)-NT227T228, OP(O)(OT229)(OT230), -OSi(T231)(T232)(T233), -OS(0 2 )-T234, NHC(O)-T235, -NT236C(O)-T237, -NH-C(O)-O-T238, -NH C(O)-NH-T239, -NH-C(O)-NT240T241, -NT242-C(O)-O-T243, 20 NT244-C(O)-NH-T245, -NT246-C(O)-NT247T248, -NHS(0 2 ) T249, -NT250S(0 2 )-T251, -S-T252, -S(O)-T253, -S(0 2 )-T254, S(0 2 )NH-T255, -S(0 2 )NT256T257, -S(O 2 )O-T258, P(O)(OT259)(OT260), -Si(T261)(T262)(T263)"; where T212, T213, T214, T215, T216, T217, T218, T219, T220, 25 T221, T222, T223, T224, T225, T226, T227,T228, T229, T230, T231, T232, T233, T234, T235, T236, T237,T238, T239, T240, T241, T242, T234, T244, T245, T246, T247,T248, T249, T250, T251, T252,T253, T254, T255, T256, T257,T258, T259, T260, T261, T262, T263 are each independently selected from the group 30 consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T218, T219 and/or T227, W02007/054556 PCT/EP2006/068322 - 408 T228 and/or T240, T241 and/or T247, T248 and/or T256, T257, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent 5 selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT264, -NT265T266, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 10 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T267, -C(O)O-T268, C(O)NH-T269, -C(O)NT270T271, -0-T272, -0(-T273-O)v-H (v = 1, 2, 3, 4, 5), -O(-T274-0),-T275 (v = 1, 2, 3, 4, 5), OC(O)-T276, -OC(O)-O-T277, -OC(O)-NHT278, -0-C(O) NT279T280, -OP(O)(OT281)(OT282), -OSi(T283)(T284)(T285), 15 -OS(0 2 )-T286, -NHC(O)-T287, -NT288C(O)-T289, -NH C(O)-O-T290, -NH-C(O)-NH-T291, -NH-C(O)-NT292T293, NT294-C(O)-O-T295, -NT296-C(O)-NH-T297, -NT298 C(O)-NT299T300, -NHS(0 2 )-T301, -NT302S(0 2 )-T303, -S T304, -S(O)-T305, -S(0 2 )-T306, -S(0 2 )NH-T307, 20 S(0 2 )NT308T309, -S(0 2 )O-T310, -P(O)(OT311)(OT312), Si(T313)(T314)(T315)"; where T264, T265, T266, T267, T268, T269, T270, T271, T272, T273, T274, T275,T276, T277,T278, T279, T280,T281, T282, T283, T284, T285,T286, T287, T288, T289, T290, T291, T292, 25 T293, T294, T295,T296, T297, T298, T299, T300,T301, T302, T303, T304, T305,T306, T307, T308,T309, T310,T311, T312, T313, T314, T315 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, 30 heteroaryl, heteroarylalkyl" and where, alternatively, T270, T271 and/or T279, T280 and/or T292, T293 and/or T299, T300 and/or T308, T309, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -409 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT316, -NT317T318, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T319, -C(O)O-T320, 10 -C(O)NH-T321, -C(O)NT322T323, -O-T324, -O(-T325 O),-H (w = 1, 2, 3, 4, 5), -O(-T326-O),-T327 (w = 1, 2, 3, 4, 5), -OC(O)-T328, -OC(O)-O-T329, -OC(O)-NHT330, O-C(O)-NT331T332, -OP(O)(OT333)(OT334), OSi(T335)(T336)(T337), -OS(0 2 )-T338, -NHC(O)-T339, 15 NT340C(O)-T341, -NH-C(O)-O-T342, -NH-C(O)-NH T343, -NH-C(O)-NT344T345, -NT346-C(O)-O-T347, NT348-C(O)-NH-T349, -NT350-C(O)-NT351T352, NHS(0 2 )-T353, -NT354S(0 2 )-T355, -S-T356, -S(O)-T357, -S(0 2 )-T358, -S(0 2 )NH-T359, -S(0 2 )NT360T361, 20 S(0 2 )O-T362, -P(O)(OT363)(OT364), Si(T365)(T366)(T367)"; where T316, T317, T318, T319, T320, T321, T322, T323, T324, T325, T326, T327, T328, T329, T330, T331, T332, T333, T334, T335, T336, T337, T338, T339, T340, T341, 25 T342, T343, T344,T345, T346, T347, T348, T349, T350, T351, T352, T353, T354, T355, T356, T357, T358, T359, T360, T361, T362, T363, T364, T365, T366, T367 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T322, T323 and/or T331, T332 and/or T344, T345 and/or T351, T352 and/or T360, T361, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 -410 (b) -NZ26Z27 where one of the Z26, Z27 radicals or both Z26, Z27 radicals are each independently selected from the group consisting of: (3) "-C(Y4)NZ28Z29, -C(=NZ30)-Z31"; where Y4 is independently selected from the group consisting of "O, S, 5 =NH, =NZ32"; with the proviso that at least one of the Z28, Z29 radicals and at least one of the Z30, Z31 radicals is independently selected from the group consisting of: (1) "alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C(O)-alkyl, -C(O) 10 aryl, -C(O)-heteroaryl"; with the further proviso that the above substituents of substituent group (1) are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: 15 (ii) "(C-C 30 )alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, N 3 , -NT368T369, -NHC(O)-cycloalkylalkyl, NHC(O)-heterocyclylalkyl, -NT370C(O)-T371, -NH-C(O)-O T372, -NH-C(O)-NH-T373, -NH-C(O)-NT374T375, -NT376 C(O)-0-T377, -NT378-C(O)-NH-T379, -NT380-C(O) 20 NT381T382, -NHS(0 2 )-cycloalkylalkyl, -NHS(0 2 ) heterocyclylalkyl, -NT383S(0 2 )-T384, -0-T385, -O(-T386 O)x-T387 (x = 1, 2, 3, 4, 5), -O(-T388-0),-H (x = 1, 2, 3, 4, 5), -OC(O)-cycloalkylalkyl, -OC(O)-heterocyclylalkyl, -OC(O)-O T389, -OC(O)-NHT390, -O-C(O)-NT391T392, -OS(0 2 ) 25 cycloalkylalkyl, -OS(0 2 )-heterocyclylalkyl, OP(O)(OT393)(OT394), -OSi(T395)(T396)(T397), -CHO, C(O)-cycloalkyl, -C(O)-heterocyclyl, -C(O)-cycloalkylalkyl, C(O)-heterocyclylalkyl, -C(O)-arylalkyl, -C(O)-heteroarylalkyl, -S- cycloalkylalkyl, -S-heterocyclylalkyl, -S-arylalkyl, -S 30 heteroarylalkyl, -S(O)-cycloalkyl, -S(O)-heterocyclyl, -S(O) heteroaryl, -S(O)-cycloalkylalkyl, -S(O)-heterocyclylalkyl, S(O)-arylalkyl, -S(O)-heteroarylalkyl, -S(0 2 )--cycloalkyl, S(0 2 )-heterocyclyl, -S(0 2 )-heteroaryl, -S(0 2 )-cycloalkylalkyl, - W02007/054556 PCT/EP2006/068322 - 411 S(0 2 )-heterocyclylalkyl, -S(0 2 )-arylalkyl, -S(0 2 ) heteroarylalkyl, -S(0 2 )NH-cycloalkyl, -S(0 2 )NH-heterocyclyl, S(0 2 )NH-cycloalkylalkyl, -S(0 2 )NH-heterocyclylalkyl, S(0 2 )NH-heteroarylalkyl, -S(0 2 )NT398T399, -S(0 2 )O 5 cycloalkyl, -S(0 2 )O-heterocyclyl, -S(0 2 )O-heteroaryl, -S(0 2 )O cycloalkylalkyl, -S(0 2 )O-heterocyclylalkyl, -S(0 2 )O heteroarylalkyl, -P(O)(OH) 2 , -P(O)(OT400)(OT401), Si(T402)(T403)(T404)"; with the further proviso that "-N(alkyl)2", "-C(O)N(alkyl) 2 ", 10 C(O)N(cycloalkyl) 2 ", "-C(O)N(Aryl)2", "-C(O)N(heteroaryl) 2 " are substituted further by at least one substituent selected from the following substituent group (ii); where T368, T369, T370, T371, T372, T373, T374, T375, T376, T377, T378, T379, T380, T381, T382, T383, T384, T385, T386, 15 T387, T388, T389, T390, T391, T392, T393, T394, T395, T396, T397, T398, T399, T400, T401, T402, T403, T404 are each independently selected from the group consisting of: "alkyl, (C 9 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and 20 where, alternatively, T374, T375 and/or T381, T382 and/or T391, T392 and/or T398, T399, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least 25 one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT405, -NT406T407, -NO 2 , 30 OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T408, -C(O)O-T409, -C(O)NH-T410, -C(O)NT411T412, -O-T413, -O(-T414 O)y-H (y = 1, 2, 3, 4, 5), -O(-T415-O)y-T416 (y = 1, 2, 3, 4, W02007/054556 PCT/EP2006/068322 -412 5), -OC(O)-T417, -OC(O)-O-T418, -OC(O)-NHT419, -0 C(O)-NT420T421, -OP(O)(OT422)(OT423), OSi(T424)(T425)(T426), -OS(0 2 )-T427, -NHC(O)-T428, NT429C(O)-T430, -NH-C(O)-O-T431, -NH-C(O)-NH 5 T432, -NH-C(O)-NT433T434, -NT435-C(O)-O-T436, NT437-C(O)-NH-T438, -NT439-C(O)-NT440T441, NHS(0 2 )-T442, -NT443S(0 2 )-T444, -S-T445, -S(O)-T446, -S(0 2 )-T447, -S(0 2 )NH-T448, -S(0 2 )NT449T450, S(0 2 )O-T451, -P(O)(OT452)(OT453), 10 Si(T454)(T455)(T456)"; where T405, T406, T407, T408, T409, T410, T411, T412, T413, T414, T415, T416, T417, T418, T419, T420, T421, T422, T423, T424, T425,T426,T427, T428, T429,T430, T431, T432, T433, T434, T435,T436, T437, T438,T439, 15 T440, T441, T442, T443, T444, T445, T446, T447, T448, T449, T450, T451, T452, T453, T454, T455, T456 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" 20 and where, alternatively, T411, T412 and/or T420, T421 and/or T433, T434 and/or T440, T441 and/or T449, T450, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least 25 one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT457, 30 -NT458T459, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T460, -C(O)O-T461, -C(O)NH-T462, -C(O)NT463T464, -O-T465, -O(-T466-0)z-H (z = 1, 2, 3, 4, 5), -O(-T467-O)z-T468 (z = 1, 2, 3, 4, 5), -OC(O)- W02007/054556 PCT/EP2006/068322 -413 T469, -OC(O)-O-T470, -OC(O)-NHT471, -0-C(O) NT472T473, -OP(O)(OT474)(OT475), OSi(T476)(T477)(T478), -OS(0 2 )-T479, -NHC(O)-T480, -NT481 C(O)-T482, -N H-C(O)-O-T483, -N H-C(O) 5 NH-T484, -NH-C(0)-NT485T486, -NT487-C(O)-O T488, -NT489-C(O)-NH-T490, -NT491-C(O) NT492T493, -NHS(0 2 )-T494, -NT495S(0 2 )-T496, -S T497, -S(O)-T498, -S(0 2 )-T499, -S(0 2 )NH-T500, S(0 2 )NT501T502, -S(0 2 )O-T503, 10 P(O)(OT504)(OT505), -Si(T506)(T507)(T508)"; where T457, T458, T459, T460, T461, T462, T463, T464, T465,T466, T467, T468, T469, T470, T471, T472, T473, T474, T475, T476, T477, T478, T479, T480, T481, T482, T483, T484, T485, T486, T487, T488, T489, T490, T491, 15 T492, T493, T494, T495, T496, T497, T498, T499, T500, T501, T502, T503, T504, T505, T506, T507, T508 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 20 heteroarylalkyl" and where, alternatively, T463, T464 and/or T472, T473 and/or T485, T486 and/or T492, T493 and/or T501, T502, in each case together, may also form "heterocyclyl"; 25 or with the proviso that at least one of the Z28, Z29 radicals and at least one of the Z30, Z31 radicals is independently selected from the group consisting of: (1l) "(Cg-C 30 )alkyl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, -C(O)-(C 9 -C 30 )alkyl, -C(O)-cycloalkyl, -C(O) 30 cycloalkylalkyl, -C(O)-arylalkyl, -C(O)-heteroarylalkyl, -C(O) heterocyclyl, -C(O)-heterocyclylalkyl, -S(0 2 )-alkyl, -S(0 2 )-(Cg C 30 )alkyl, -S(0 2 )-cycloalkyl, -S(0 2 )-cycloalkylalkyl, -S(0 2 )-aryl, - W02007/054556 PCT/EP2006/068322 - 414 S(0 2 )-arylalkyl, -S(0 2 )-heteroaryl, -S(0 2 )-heteroarylalkyl, -S(O2) heterocyclyl, -S(0 2 )-heterocyclylalkyl"; where, optionally, the above substituents of substitution group (ll) may each independently be further substituted by at least one 5 substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT509, -NT51T511, -N2, -OH, 10 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T512, -C(O)O-T513, C(O)NH-T514, -C(O)NT515T516, -0-T517, -O(-T518-0)a-H (a = 1, 2, 3, 4, 5), -0(-T519-0)a-T520 (a = 1, 2, 3, 4, 5), OC(O)-T521, -OC(O)-O-T522, -OC(O)-NHT523, -0-C(O) 15 NT524T525, -OP(O)(OT526)(OT527), -OSi(T528)(T529)(T530), -OS(0 2 )-T531, -NHC(O)-T532, -NT533C(O)-T534, -NH C(O)-O-T535, -NH-C(O)-NH-T536, -NH-C(O)-NT537T538, NT539-C(O)-O-T540, -NT541-C(O)-NH-T542, -NT543 C(O)-NT544T545, -NHS(0 2 )-T546, -NT547S(0 2 )-T548, -S 20 T549, -S(O)-T550, -S(0 2 )-T551, -S(0 2 )NH-T552, S(0 2 )NT553T554, -S(0 2 )O-T555, -P(O)(OT556)(OT557), Si(T558)(T559)(T560)"; where T509, T510, T511, T512, T513, T514, T515, T516, T517, T518, T519, T520, T521, T522, T523, T524, T525, T526, T527, 25 T528, T529, T530, T531, T532, T533, T534, T535, T536, T537, T538, T539, T540, T541, T542, T543, T544, T545, T546, T547, T548, T549, T550, T551, T552, T553, T554, T555, T556, T557, T558, T559, T560 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, 30 cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T515, T516 and/or T524, T525 and/or T537, T538 and/or T544, T545 and/or T553, T554, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 415 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT561, -NT562T563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T564, -C(O)O-T565, 10 -C(O)NH-T566, -C(O)NT567T568, -O-T569, -O(-T570 O)b-H (b = 1, 2, 3, 4, 5), -O(-T571-O)b-T572 (b = 1, 2, 3, 4, 5), -OC(O)-T573, -OC(O)-O-T574, -OC(O)-NHT575, -0 C(O)-NT576T577, -OP(O)(OT578)(OT579), OSi(T580)(T581)(T582), -OS(0 2 )-T583, -NHC(O)-T584, 15 NT585C(O)-T586, -NH-C(O)-O-T587, -NH-C(O)-NH T588, -NH-C(O)-NT589T590, -NT591-C(O)-O-T592, NT593-C(O)-NH-T594, -NT595-C(O)-NT596T597, NHS(0 2 )-T598, -NT599S(0 2 )-T600, -S-T601, -S(O)-T602, -S(0 2 )-T603, -S(0 2 )NH-T604, -S(0 2 )NT605T606, 20 S(0 2 )O-T607, -P(O)(OT608)(OT609), Si(T61 0)(T61 1)(T612)"; where T561, T562, T563, T564, T565, T566, T567, T568, T569, T570, T571, T572, T573, T574, T575, T576, T577, T578, T579, T580, T581, T582, T583, T584, T585, T586, 25 T587, T588, T589, T590, T591, T592, T593, T594, T595, T596, T597, T598, T599, T600, T601, T602, T603, T604, T605, T606, T607, T608, T609, T610, T611, T612 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T567, T568 and/or T576, T577 and/or T589, T590 and/or T596, T597 and/or T605, T606, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 416 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT613, -NT614T615, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 10 P(O)(OH) 2 , -C(O)-T616, -C(O)O-T617, -C(O)NH-T618, -C(O)NT619T620, -O-T621, -O(-T622-O)c-H (c = 1, 2, 3, 4, 5), -O(-T623-O)c-T624 (c = 1, 2, 3, 4, 5), -OC(O) T625, -OC(O)-O-T626, -OC(O)-NHT627, -0-C(O) NT628T629, -OP(O)(OT630)(OT631), 15 OSi(T632)(T633)(T634), -OS(0 2 )-T635, -NHC(O)-T636, -NT637C(O)-T638, -NH-C(O)-O-T639, -NH-C(O) NH-T640, -NH-C(O)-NT641T642, -NT643-C(O)-O T644, -NT645-C(O)-NH-T646, -NT647-C(O) NT648T649, -N HS(0 2 )-T650, -NT651 S(0 2 )-T652, -S 20 T653, -S(O)-T654, -S(0 2 )-T655, -S(0 2 )NH-T656, S(0 2 )NT657T658, -S(0 2 )O-T659, P(O)(OT660)(OT661), -Si(T662)(T663)(T664)"; where T613, T614, T615, T616, T617, T618, T619, T620, T621, T622, T623, T624, T625, T626, T627, T628, T629, 25 T630, T631, T632, T633, T634, T635, T636, T637, T638, T639, T640, T641, T642, T643,T644, T645, T646, T647, T648,T649, T650,T651,T652, T653, T654, T655, T656, T657, T658, T659, T660, T661, T662, T663, T664 are each independently selected from the group consisting 30 of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T619, T620 and/or T628, T629 and/or T641, T642 and/or T648, T649 W02007/054556 PCT/EP20061068322 -417 and/or T657, T658, in each case together, may also form "heterocyclyl"; and one of the Z28, Z29 radicals or neither of the Z28, Z29 radicals and 5 one of the Z30, Z31 radicals or neither of the Z30, Z31 radicals and the Z32 radical is independently selected from the group consisting of: (Ill)"hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C(O) alkyl, -C(O)-aryl, -C(O)-heteroaryl"; where, optionally, the above substituents of substituent group (Ill) 10 may each independently in turn be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 15 Br, I, CN, CF 3 , N 3 , NH 2 , -NHT665, -NT666T667, -NO 2 , -OH, OCF 3 , -SH, -0-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T668, -C(O)O-T669, C(O)NH-T670, -C(O)NT671T672, -0-T673, -0(-T674-O)d-H (d = 1, 2, 3, 4, 5), -O(-T675-0)d-T676 (d = 1, 2, 3, 4, 5), 20 OC(O)-T677, -OC(O)-0-T678, -OC(O)-NHT679, -0-C(O) NT680T681, -OP(O)(OT682)(OT683), -OSi(T684)(T685)(T686), -OS(0 2 )-T687, -NHC(O)-T688, -NT689C(O)-T690, -NH C(O)-O-T691, -NH-C(O)-NH-T692, -NH-C(O)-NT693T694, NT695-C(O)-O-T696, -NT697-C(O)-NH-T698, -NT699 25 C(O)-NT700T701, -NHS(0 2 )-T702, -NT703S(0 2 )-T704, -S T705, -S(O)-T706, -S(0 2 )-T707, -S(0 2 )NH-T708, S(0 2 )NT709T71 0, -S(0 2 )O-T71 1, -P(O)(OT712)(OT713), Si(T714)(T715)(T716)"; where T665, T666, T667, T668, T669, T670, T671, T672, T673, 30 T674, T675, T676, T677, T678, T679, T680, T681, T682, T683, T684, T685, T686, T687, T688, T689, T690, T691, T692, T693, T694, T695, T696, T697, T698, T699, T700, T701, T702, T703, T704, T705, T706, T707, T708, T709, T710, T711, T712, T713, W02007/054556 PCT/EP2006/068322 - 418 T714, T715, T716 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T671, T672 5 and/or T680, T681 and/or T693, T694 and/or T700, T701 and/or T709, T71 0, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group 10 consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT717, -NT718T719, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 15 -C(O)NH 2 , -SO 3 H, -P(O)(OH)2, -C(O)-T720, -C(O)O-T721, -C(O)NH-T722, -C(O)NT723T724, -O-T725, -O(-T726 O)e-H (e = 1, 2, 3, 4, 5), -O(-T727-0)-T728 (e = 1, 2, 3, 4, 5), -OC(O)-T729, -OC(O)-O-T730, -OC(O)-NHT731, -0 C(O)-NT732T733, -OP(O)(OT734)(OT735), 20 OSi(T736)(T737)(T738), -OS(0 2 )-T739, -NHC(O)-T740, NT741C(O)-T742, -NH-C(O)-O-T743, -NH-C(O)-NH T744, -NH-C(O)-NT745T746, -NT747-C(O)-O-T748, NT749-C(O)-NH-T750, -NT751-C(O)-NT752T753, NHS(0 2 )-T754, -NT755S(0 2 )-T756, -S-T757, -S(O)-T758, 25 -S(0 2 )-T759, -S(0 2 )NH-T760, -S(0 2 )NT761T762, S(0 2 )O-T763, -P(O)(OT764)(OT765), Si(T766)(T767)(T768)"; where T717, T718, T719, T720, T721, T722, T723, T724, T725, T726,T727, T728, T729, T730, T731, T732, T733, 30 T734, T735,T736, T737, T738, T739, T740, T741, T742, T743, T744,T745, T746,T747, T748, T749, T750, T751, T752, T753,T754, T755,T756, T757, T758, T759, T760, T761, T762, T763, T764, T765, T766, T767, T768 are each independently selected from the group consisting of: "alkyl, W02007/054556 PCT/EP2006/068322 -419 (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T723, T724 and/or T732, T733 and/or T745, T746 and/or T752, T753 and/or T761, T762, in 5 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT769, -NT770T771, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 15 P(O)(OH)2, -C(O)-T772, -C(O)O-T773, -C(O)NH-T774, -C(O)NT775T776, -0-T777, -O(-T778-O)rH (f = 1, 2, 3, 4, 5), -O(-T779-O)rT780 (f = 1, 2, 3, 4, 5), -OC(O) T781, -OC(O)-O-T782, -OC(O)-NHT783, -0-C(O) NT784T785, -OP(O)(OT786)(OT787), 20 OSi(T788)(T789)(T790), -OS(0 2 )-T791, -NHC(O)-T792, -NT793C(O)-T794, -NH-C(O)-O-T795, -NH-C(O) NH-T796, -NH-C(O)-NT797T798, -NT799-C(O)-O T800, -NT801-C(O)-NH-T802, -NT803-C(O) NT804T805, -NHS(0 2 )-T806, -NT807S(0 2 )-T808, -S 25 T809, -S(O)-T810, -S(0 2 )-T81 1, -S(O 2 )NH-T812, S(0 2 )NT813T814, -S(0 2 )O-T815, P(O)(OT816)(OT817), -Si(T818)(T819)(T820)"; where T769, T770, T771, T772, T773, T774, T775, T776, T777, T778, T779, T780, T781, T782, T783,T784, T785, 30 T786, T787, T788,T789, T790, T791, T792, T793, T794, T795, T796, T797, T798, T799, T800, T801, T802, T803, T804, T805, T806,T807, T808, T809, T810, T811, T812, T813, T814, T815, T816, T817, T818, T819, T820 are each independently selected from the group consisting W02007/054556 PCT/EP2006/068322 - 420 of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T775, T776 and/or T784, T785 and/or T797, T798 and/or T804, T805 5 and/or T813, T814, in each case together, may also form "heterocyclyl"; (2) "-C(Y5)NZ33-Y6-Z34"; where Y5, Y6 are each independently selected from the group 10 consisting of "O, S, =NH, =NZ35"; where Z33, Z34, Z35 are each independently selected from the group consisting of: (1) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 15 heteroarylalkyl, -C(O)-alkyl, -C(O)-(C 9 -C 30 )alkyl, -C(O)-cycloalkyl, -C(O)-cycloalkylalkyl, -C(O)-aryl, -C(O)-arylalkyl, -C(O) heteroaryl, -C(O)-heteroarylalkyl, -C(O)-heterocycly, -C(O) heterocyclylalkyl, -S(0 2 )-alkyl, -S(0 2 )-(Cg-C 30 )alkyl, -S(0 2 ) cycloalkyl, -S(0 2 )-cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2 )-arylalkyl, 20 S(0 2 )-heteroaryl, -S(0 2 )-heteroarylalkyl, -S(0 2 )-heterocyclyl, S(0 2 )-heterocyclylalkyl"; where, optionally, the above substituents of substituent group (1) may each independently in turn be substituted by at least one substituent selected identically or differently from the group 25 consisting of: (ii) "alkyl, (C9-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT821, -NT822T823, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 30 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T824, -C(O)O-T825, C(O)NH-T826, -C(O)NT827T828, -O-T829, -O(-T830-0)-H (g = 1, 2, 3, 4, 5), -0(-T831-O)g-T832 (g = 1, 2, 3, 4, 5), OC(O)-T833, -OC(O)-O-T834, -OC(O)-NHT835, -O-C(O)- W02007/054556 PCT/EP2006/068322 -421 NT836T837, -OP(O)(OT838)(OT839), -OSi(T840)(T814)(T842), -OS(0 2 )-T843, -NHC(O)-T844, -NT845C(O)-T846, -NH C(O)-O-T847, -NH-C(O)-NH-T848, -NH-C(O)-NT849T850, NT851-C(O)-O-T852, -NT853-C(O)-NH-T854, -NT855 5 C(O)-NT856T857, -NHS(0 2 )-T858, -NT859S(0 2 )-T860, -S T861, -S(O)-T862, -S(0 2 )-T863, -S(0 2 )NH-T864, S(0 2 )NT865T866, -S(0 2 )O-T867, -P(O)(OT868)(OT869), Si(T870)(T871)(T872)"; where T821, T822, T823, T824, T825, T826, T827, T828, T829, 10 T830, T831, T832, T833, T834, T835, T836, T837,T838, T839, T840, T841, T842, T843, T844,T845, T846, T847, T848, T849, T850, T851, T852, T853, T854, T855, T856, T857, T858, T859, T860, T861, T862, T863, T864, T865, T866, T867, T868, T869, T870, T871, T872 are each independently selected from the 15 group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T827, T828 and/or T836, T837 and/or T849, T850 and/or T856, T857 and/or T865, T866, in each case together, may also form "heterocyclyl"; 20 where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT873, -NT874T875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T876, -C(O)O-T877, -C(O)NH-T878, -C(O)NT879T880, -O-T881, -O(-T882 30 O)h-H (h = 1, 2, 3, 4, 5), -O(-T883-O)h-T884 (h = 1, 2, 3, 4, 5), -OC(O)-T885, -OC(O)-O-T886, -OC(O)-NHT887, -0 C(O)-NT888T889, -OP(O)(OT890)(OT891), OSi(T892)(T893)(T894), -OS(0 2 )-T895, -NHC(O)-T896, NT897C(O)-T898, -NH-C(O)-O-T899, -NH-C(O)-NH- W02007/054556 PCT/EP2006/068322 - 422 T900, -NH-C(O)-NT901T902, -NT903-C(O)-O-T904, NT905-C(O)-NH-T906, -NT907-C(O)-NT908T909, NHS(0 2 )-T910, -NT911S(0 2 )-T912, -S-T913, -S(O)-T914, -S(0 2 )-T915, -S(0 2 )NH-T916, -S(0 2 )NT917T918, 5 S(0 2 )O-T919, -P(O)(OT920)(OT921), Si(T922)(T923)(T924)"; where T873, T874, T875, T876, T877, T878, T879, T880, T881, T882, T883, T884, T885, T886, T887, T888, T889, T890, T891, T892,T893, T894,T895,T896, T897, T898, 10 T899, T900, T901, T902, T903, T904, T905, T906, T907, T908, T909, T910,T911, T912,T913, T914, T915, T916, T917, T918, T919, T920, T921, T922, T923, T924 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T879, T880 and/or T888, T889 and/or T901, T902 and/or T908, T909 and/or T917, T918, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group 20 (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C9-C30)alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, 25 heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT925, -NT926T927, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH)2, -C(O)-T928, -C(O)O-T929, -C(O)NH-T930, -C(O)NT931T932, -0-T933, -O(-T934-O)r-H (i = 1, 2, 30 3, 4, 5), -O(-T935-0)r-T936 (i = 1, 2, 3, 4, 5), -OC(O) T937, -OC(O)-O-T938, -OC(O)-NHT939, -0-C(O) NT940T941, -OP(O)(OT942)(OT943), OSi(T944)(T945)(T946), -OS(0 2 )-T947, -NHC(O)-T948, -NT949C(O)-T950, -NH-C(O)-O-T951, -NH-C(O)- W02007/054556 PCT/EP2006/068322 - 423 NH-T952, -NH-C(O)-NT953T954, -NT955-C(O)-O T956, -NT957-C(O)-NH-T958, -NT959-C(O) NT960T961, -NHS(0 2 )-T962, -NT963S(0 2 )-T964, -S T965, -S(O)-T966, -S(0 2 )-T967, -S(0 2 )NH-T968, 5 S(0 2 )NT969T970, -S(0 2 )O-T971, P(O)(OT972)(OT973), -Si(T974)(T975)(T976)"; where T925, T926, T927, T928, T929, T930, T931, T932, T933, T934, T935, T936,T937,T938,T939, T940, T941, T942, T943, T944, T945, T946, T947, T948, T949, T950, 10 T951, T952, T953, T954, T955, T956, T957, T958, T959, T960, T961, T962, T963, T964, T965, T966, T967, T968, T969, T970, T971, T972, T973, T974, T975, T976 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 15 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T931, T932 and/or T940, T941 and/or T953, T954 and/or T960, T961 and/or T969, T970, in each case together, may also form "heterocyclyl"; 20 and one of the Z26, Z27 radicals or neither of the Z26, Z27 radicals is also independently selected from the group consisting of: (2) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O)-alkyl, 25 -C(O)-(C-C 30 )alkyl, -C(O)-cycloalkyl, -C(O)-cycloalkylalkyl, -C(O) aryl, -C(O)-arylalkyl, -C(O)-heteroaryl, -C(O)-heteroarylalkyl, -C(O) heterocyclyl, -C(O)-heterocyclylalkyl, -C(Y7)NZ36Z37, -C(=NZ38) Z39, -S(0 2 )-alkyl, -S(0 2 )-(C-C 30 )alkyl, -S(0 2 )-cycloalkyl, -S(0 2 ) cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2 )-arylalkyl, -S(O 2 )-heteroaryl, 30 S(0 2 )-heteroarylalkyl, -S(0 2 )-heterocyclyl, -S(0 2 )-heterocyclylalkyl"; where Y7 is independently selected from the group consisting of "0, S, =NH, =NZ40"; W02007/054556 PCT/EP2006/068322 - 424 where the Z36, Z37, Z38, Z39, Z40 radicals are each independently selected from the group consisting of: (I) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) 5 alkyl, -C(O)-(C-C 30 )alkyl, -C(O)-cycloalkyl, -C(O)-cycloalkylalkyl, -C(O)-aryl, -C(O)-arylalkyl, -C(O)-heteroaryl, -C(O) heteroarylalkyl, -C(O)-heterocyclyl, -C(O)-heterocyclylalkyl, S(0 2 )-alkyl, -S(0 2 )-(C-C 30 )alkyl, -S(0 2 )-cycloalkyl, -S(0 2 ) cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2 )-arylalkyl, -S(0 2 )-heteroaryl, 10 S(0 2 )-heteroarylalkyl, -S(0 2 )-heterocyclyl, -S(O2) heterocyclylalkyl"; where, optionally, the above substituents of substituent group (3) and/or substituent group (1) may each independently in turn be substituted by at least one substituent selected identically or differently from the group 15 consisting of: (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT977, -NT978T979, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, 20 P(O)(OH) 2 , -C(O)-T980, -C(O)O-T981, -C(O)NH-T982, C(O)NT983T984, -O-T985, -O(-T986-O);-H (j = 1, 2, 3, 4, 5), -O( T987-O)-T988 (j = 1, 2, 3, 4, 5), -OC(O)-T989, -OC(O)-O-T990, OC(O)-NHT991, -0-C(O)-NT992T993, -OP(O)(OT994)(OT995), OSi(T996)(T997)(T998), -OS(0 2 )-T999, -NHC(O)-T1000, 25 NT1001C(O)-T1002, -NH-C(O)-O-T1003, -NH-C(O)-NH-T1004, -NH-C(O)-NT1 005T1 006, -NT1 007-C(O)-O-T1 008, -NT1 009 C(O)-NH-T1010, -NT1011-C(O)-NT1012T1013, -NHS(0 2 ) T1014, -NT1015S(O 2 )-T1016, -S-T1017, -S(O)-T1018, -S(0 2 ) T1019, -S(0 2 )NH-T1020, -S(0 2 )NT1021T1022, -S(0 2 )0-T1023, 30 P(O)(OT1024)(OT1025), -Si(T1026)(T1027)(T1028)"; where T977, T978, T979, T980, T981, T982, T983, T984, T985, T986, T987, T988, T989, T990, T991, T992, T993, T994, T995, T996, T997, T998, T999, T1000, T1001, T1002, T1003, T1004, W02007/054556 PCT/EP2006/068322 - 425 T1005, T1006, T1007, T1008, T1009, T1010, T1011, T1012, T1013, T1014, T1015, T1016, T1017, T1018, T1019, T1020, T1021, T1022, T1023, T1024, T1025, T1026, T1027, T1028 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, 5 cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T983, T984 and/or T992, T993 and/or T1005, T1006 and/or T1012, T1013 and/or T1 021, T1 022, in each case together, may also form "heterocyclyl"; 10 where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1029, -NT1030T1031, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1032, -C(0)0-T1033, C(O)NH-T1034, -C(O)NT1035T1036, -O-T1037, -O(-T1038 20 O)k-H (k = 1, 2, 3, 4, 5), -O(-T1039-O)k-T1040 (k = 1, 2, 3, 4, 5), -0C(O)-T1041, -OC(O)-O-T1042, -OC(O)-NHT1043, -0 C(O)-NT1044T1045, -OP(O)(OT1046)(OT1047), OSi(T1048)(T1049)(T1050), -OS(0 2 )-T1051, -NHC(O)-T1052, -NT1053C(O)-T1054, -NH-C(O)-O-T1055, -NH-C(O)-NH 25 T1056, -NH-C(O)-NT1057T1058, -NT1059-C(O)-O-T1060, NT1061-C(O)-NH-T1062, -NT1063-C(O)-NT1064T1065, NHS(0 2 )-T1 066, -NT1 067S(0 2 )-T1 068, -S-T1 069, -S(O) T1070, -S(0 2 )-T1071, -S(0 2 )NH-T1072, -S(0 2 )NT1073T1074, -S(0 2 )O-T1075, -P(O)(OT1076)(OT1077), 30 Si(T1078)(T1079)(T1080)"; where T1029, T1030, T1031, T1032, T1033, T1034, T1035, T1036, T1037, T1038, T1039, T1040, TlO41, T1042, T1043, T1044, T1045, T1046, T1047, T1048,T1049, T1O5O, T1O51, T1052, T1053,T1054, T1O55, T1056, T1057, T1058, T1059, W02007/054556 PCT/EP2006/068322 -426 T1060, T1061, T1062, T1063, T1064, T1065,T1066,T1067, T1068, T1069, T1070, T1071, T1072, T1073,T1074, T1075, T1 076, T1 077, T1078, T1 079, T1080 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, 5 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1035, T1036 and/or T1044, T1045 and/or T1057, T1058 and/or T1 064, T1 065 and/or T1073, T1 074, in each case together, may also form "heterocyclyl"; 10 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1081, -NT1082T1083, NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1084, C(O)O-T1 085, -C(O)NH-Ti 086, -C(O)NT1 087T1 088, -0 20 T1089, -O(-T1090-O)rH (I = 1, 2, 3, 4, 5), -O(-T1091-O)r T1092 (1 = 1, 2, 3, 4, 5), -OC(O)-T1093, -OC(O)-O-T1094, -OC(O)-NHT1095, -0-C(O)-NT1096T1097, OP(O)(OT1098)(OT1099), -OSi(T 100)(T1101)(T1 102), OS(O 2 )-T1 103, -NHC(O)-T1104, -NT1 105C(O)-T1 106, 25 NH-C(O)-O-T1 107, -NH-C(O)-NH-T1 108, -NH-C(O) NT1109T1110, -NT1111-C(O)-O-T1112, -NT1113-C(O) NH-T1114, -NT1115-C(O)-NT1116T1117, -NHS(0 2 ) T1118, -NT1119S(0 2 )-T1120, -S-T1121, -S(O)-T1122, S(0 2 )-T1 123, -S(0 2 )NH-T1 124, -S(0 2 )NT1 125T1 126, 30 S(0 2 )O-T1 127, -P(O)(OT1 128)(OT1 129), Si(T1 130)(T1 131)(T1 132)"; where T1 081, T1082, T1083, T1 084, T1085, T1086, T1 087, T1088, T1089, T1O9O, T1O91, T1092, T1093, T1094, T1095, T1096, T1097, T1098, T1099, T1100, T1l0l, T1lO2, T1103, W02007/054556 PCT/EP2006/068322 - 427 T1104, T1105,T1106, T1107, T1108, T1109, T11, T11, T1112, T1113, T1114, T1115, T1116, T1117, T1118, T1119, T1120, T1121,T1122, T1123, T1124, T1125, T1126, T1127, T1128, T1129, T1130, T1131, T1132 are each independently 5 selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 087, T1088 and/or T1096, T1097 and/or T1109, T1110 and/or T1116, T1117 and/or T1125, T1126, in 10 each case together, may also form "heterocyclyl"; and one of the Z1, Z2 radicals or neither of the Z1, Z2 radicals is independently selected from the group consisting of: (c) hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT1133, -NT1134T1135, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-T1136, -C(O)O-T1137, -C(O)NH-T1138, C(O)NT1139T1140, -O-T1141, -0(-T1142-0)m-H (m = 1, 2, 3, 4, 5), 20 O(-T1 143-0)m-Tl 144 (m = 1, 2, 3, 4, 5), -OC(O)-T1 145, -OC(O)-O T1 146, -OC(O)-NHT1 147, -0-C(O)-NT1 148T1 149, OP(O)(OT1 150)(OT1 151), -OSi(T1 152)(T1 153)(T1 154), -OS(0 2 )-T1 155, -NHC(O)-T1 156, -NT1 157C(O)-Ti 158, -NH-C(O)-O-T1 159, -NH C(O)-NH-T1160, -NH-C(O)-NT1161T1162, -NT1163-C(O)-O-T1164, 25 -NT1165-C(O)-NH-T1166, -NT1167-C(O)-NT1168T1169, -NHS(0 2 ) T1170, -NT1171S(O 2 )-T1172, -S-T1173, -S(O)-T1174, -S(0 2 )-T1175, -S(0 2 )NH-T1176, -S(0 2 )NT1177T1178, -S(0 2 )O-T1179, P(O)(OT1 180)(OT1 181), -Si(T1 182)(T1 183)(T1 184)"; where T1133, T1134, T1135, T1136, T1137, T1138, T1139, T1140, 30 T1141,T1142,T1143,T1144,T1145,T1146,T1147,T1148,T1149, T1150, T1l51, T1152, T1153, T1154, T1155, T1156, T1157, T1158, T1159, T1160, T1161, T1162, T1163, T1164, T1165, T1166, T1167, T1168, T1169, T1170, T1171, T1172, T1173, T1174, T1175, T1176, W02007/054556 PCT/EP2006/068322 -428 T1177, T1178, T1179, T1180, T1181, T1182, T1183, T1184 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 139, T1 140 and/or 5 T1148, T1149 and/or T1161, T1162 and/or T1168, T1169 and/or T1177, TI 178, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (c) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 10 (i) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1 185, -NT1 186T1 187, -NO 2 , -OH, -OCF 3 , SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-Ti 188, -C(O)O-Ti 189, -C(O)NH-Ti 190, 15 C(O)NT1191T1192, -O-T1193, -O(-T1194-O)r-H (n = 1, 2, 3, 4, 5), -O(-T 1195-O),-T1 196 (n = 1, 2, 3, 4, 5), -OC(O)-Ti 197, -OC(O) O-T1 198, -OC(O)-NHT1 199, -O-C(O)-NT1200T1201, OP(O)(OT1202)(OT1203), -OSi(T1204)(T1205)(T1206), -OS(0 2 ) T1207, -NHC(O)-T1208, -NT1209C(O)-T1210, -NH-C(O)-O 20 T1211, -NH-C(O)-NH-T1212, -NH-C(O)-NT1213T1214, -NT1215 C(O)-O-T1216, -NT1217-C(O)-NH-T1218, -NT1219-C(O) NT1220T1221, -NHS(0 2 )-T1222, -NT1223S(O 2 )-T1224, -S-T1225, -S(O)-T1 226, -S(0 2 )-T1 227, -S(0 2 )NH-T1 228, S(0 2 )NT1229T1230, -S(0 2 )O-T1231, -P(O)(OT1232)(OT1233), 25 Si(T1234)(T1235)(T1236)"; where T1185, T1186, T1187, T1188, T1189, T1190, T1191, T1192, T1193, T1194, T1195, T1196, T1197, T1198, T1199, T1200, T1201, T1202, T1203, T1204, T1205, T1206, T1207, T1208, T1209, T1210, T1211, T1212, T1213, T1214, T1215, T1216, T1217, T1218, T1219, 30 T1220, T1221, T1222, T1223, T1224, T1225, T1226, T1227, T1228, T1229, T1230, T1231, T1232, T1233, T1234, T1235, T1236 are each independently selected from the group consisting of: "alkyl, (CO C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, W02007/054556 PCT/EP2006/068322 - 429 T1191, T1192 and/or T1200, T1201 and/or T1213, T1214 and/or T1220, T1221 and/or T1229, T1 230, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may 5 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT1237, -NT1238T1239, -NO 2 , -OH, 10 OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1240, -C(O)O-T1241, -C(O)NH T1242, -C(O)NT1243T1244, -O-T1245, -O(-T1246-O),-H (o = 1, 2, 3, 4, 5), -O(-T1 247-0)o-T1 248 (o = 1, 2, 3, 4, 5), -OC(O) T1249, -OC(O)-O-T1250, -OC(O)-NHT1251, -0-C(O) 15 NT1252T1253, -OP(O)(OT1254)(OT1255), OSi(T1256)(T1257)(T1258), -OS(0 2 )-T1259, -NHC(O)-T1260, NT1261C(O)-T1262, -NH-C(O)-O-T1263, -NH-C(O)-NH T1264, -NH-C(O)-NT1265T1266, -NT1267-C(O)-O-T1268, NT1269-C(O)-NH-T1270, -NT1271-C(O)-NT1272T1273, 20 NHS(0 2 )-T1274, -NT1275S(O 2 )-T1276, -S-T1277, -S(O) T1 278, -S(0 2 )-T1 279, -S(0 2 )NH-T1 280, -S(0 2 )NT1 281 T1 282, S(0 2 )O-T1283, -P(O)(OT1284)(OT1285), Si(T1 286)(T1 287)(T1 288)"; where T1237, T1238, T1239, T1240, T1241, T1242, T1243, 25 T1244, T1245, T1246,T1247, T1248, T1249, T1250, T1251, T1252, T1253, T1254,T1255, T1256, T1257, T1258, T1259, T1260, T1261, T1262,T1263, T1264, T1265, T1266, T1267, T1268, T1269, T1270, T1271, Ti272, T1273, T1274, T1275, T1276, T1277, T1278,T1279, T1280, T1281, T1282, T1283, 30 T1284, T1 285, T1 286, T1 287, T1288 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 243, T1244 and/or T1252, T1253 and/or T1265, T1 266 and/or W02007/054556 PCT/EP2006/068322 -430 T1 272, T1 273 and/or T1281, T1282, in each case together, may also form "heterocyclyl"; (d) -NZ41Z42 where the Z41, Z42 radicals are each independently selected 5 from the group consisting of: (1) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) alkyl, -C(O)-(C-C 30 )alkyl, -C(O)-cycloalkyl, -C(O)-cycloalkylalkyl, C(O)-aryl, -C(O)-arylalkyl, -C(O)-heteroaryl, -C(O)-heteroarylalkyl, 10 -C(O)-heterocyclyl, -C(O)-heterocyclylalkyl"; where, optionally, the above substituents of substituent group (1) may each independently be substituted further by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1289, -NT1290T1291, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1292, -C(O)O-T1293, -C(O)NH T1294, -C(O)NT1295T1296, -O-T1297, -O(-TI298-0),-H (rr = 20 1, 2, 3, 4, 5), -O(-T1 299-0),-T1300 (rr = 1, 2, 3, 4, 5), -OC(O) T1301, -OC(O)-O-T1302, -OC(O)-NHT1303, -0-C(O) NT1304T1 305, -OP(O)(OT1306)(OT1 307), OSi(T1 308)(T1 309)(T1 310), -OS(0 2 )-T1 311, -NHC(O)-T1 312, NT1313C(O)-T1314, -NH-C(O)-O-T1315, -NH-C(O)-NH 25 T1316, -NH-C(O)-NT1317T1318, -NT1319-C(O)-0-T1320, NT1321-C(O)-NH-T1322, -NT1323-C(O)-NT1324T1325, NHS(0 2 )-T1326, -NT1327S(0 2 )-T1328, -S-T1329, -S(O) T1 330, -S(0 2 )-T1 331, -S(0 2 )NH-T1 332, -S(0 2 )NT1 333T1 334, S(0 2 )O-T1335, -P(O)(OT1336)(OT1337), 30 Si(T1 338)(T1 339)(T1 340)"; where T1289, T1290, T1291, T1292, T1293, T1294, T1295, T1296, T1297, T1298, Ti299, T1300, T130, T1302, T1303, T1304, T1305, T1306,Ti307, T1308, T1309, T131O, T1311, W02007/054556 PCT/EP2006/068322 -431 T1312, T1313, T1314, T1315, T1316, T1317, T1318, T1319, T1320,T1321, T1322, T1323, T1324, T1325, T1326, T1327, T1328, T1329, T1330, T1331, T1332, T1333, T1334, T1335, T1336, T1 337, T1338, T1339, T1 340 are each independently 5 selected from the group consisting of: "alkyl, (C-C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1295, T1296 and/or T1304, T1305 and/or T1317, T1318 and/or T1324, T1 325 and/or T1333, T1334, in each case together, may 10 also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 15 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1341, -NT1342T1343, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1344, -C(0)0 20 T1345, -C(O)NH-T1346, -C(O)NT1347T1348, -O-T1349, O(-T1350-0)r-H (rs = 1, 2, 3, 4, 5), -O(-T1351-0)rs-T1 352 (rs = 1, 2, 3, 4, 5), -OC(O)-T1353, -OC(O)-O-T1354, OC(O)-NH T1355, -O-C(O)-NT1356T1357, OP(O)(OT1358)(OT1359), -OSi(T1360)(T1361)(T1362), 25 OS(0 2 )-T1363, -NHC(O)-T1364, -NT1365C(O)-T1366, NH-C(O)-O-T1 367, -NH-C(O)-NH-T1 368, -NH-C(O) NT1 369T1 370, -NT1 371-C(O)-O-T1 372, -NT1 373-C(O) NH-T1374, -NT1 375-C(O)-NT1 376T1377, -NHS(0 2 )-T1378, -NT1 379S(0 2 )-T1 380, -S-T1 381, -S(O)-Ti 382, -S(02) 30 T1383, -S(0 2 )NH-T1 384, -S(0 2 )NTI 385T1 386, -S(0 2 )0 T1 387, -P(O)(OT1 388)(OT1 389), -Si(T1 390)(T1 391)(T1 392)"; where T1341, T1342, T1343, T1344, T1345, T1346, T1347, T1348, T1349, T1350, T1351, T1352, T1353, T1354, T1355, T1356, T1357, T1358, T1359, T1360, T1361, T1362, T1363, W02007/054556 PCT/EP2006/068322 -432 T1364, T1365, T1366, T1367, T1368, T1369, T1370, T1371, T1372, T1373, T1374, T1375, T1376, T1377, T1378, T1379, T1380, T1381, T1382, T1383, T1384, T1385, T1386, T1387, T1 388, T1 389, T1 390, T1 391, T1 392 are each independently 5 selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1347, T1348 and/or T1356, T1357 and/or T1369, T1 370 and/or T1376, T1377 and/or T1385, T1386, in each case 10 together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (iii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT1393, -NT1394T1395, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-Ti 396, 20 C(O)O-T1397, -C(O)NH-T1398, -C(O)NT1399T1400, O-T1401, -O(-T1402-0),-H (rt = 1, 2, 3, 4, 5), -O( T1403-0)rt-T1404 (rt = 1, 2, 3, 4, 5), -OC(O)-T1405, OC(O)-O-T1406, -OC(O)-NHT1407, -0-C(O) NT1408T1409, -OP(O)(OT1410)(OT1 411), 25 OSi(T1412)(T1413)(T1414), -OS(0 2 )-T1415, -NHC(O) T1416, -NT1417C(O)-T1418, -NH-C(O)-O-T1419, -NH C(O)-NH-T1420, -NH-C(O)-NT1421T1422, -NT1423 C(O)-O-T1424, -NT1425-C(O)-NH-T1426, -NT1427 C(O)-NT1428T1429, -NHS(0 2 )-T1430, -NT1431S(0 2 ) 30 T1432, -S-T1433, -S(O)-T1434, -S(0 2 )-Ti435, S(0 2 )NH-T1436, -S(0 2 )NT1437T1438, -S(0 2 )O-T1439, P(O)(OT1440)(OT1441), -Si(T1442)(T1443)(T1444)"; where T1393, T1394, T1395, T1396, T1397, T1398, T1399, T1400, T140, T1402,T1403, T1404, T1405, W02007/054556 PCT/EP2006/068322 - 433 T1406, T1407, T1408, T1409, T1410, T1411, T1412, T1413, T1414, T1415, T1416, T1417, T1418, T1419, T1420, T1421, T1422, T1423, T1424, T1425, T1426, T1427, T1428, T1429, T1430, T1431, T1432, T1433, 5 T1434, T1435, T1436, T1437, T1438, T1439, T1440, T1441, T1442, T1443, T1444 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, 10 alternatively, T1399, T1400 and/or T1408, T1409 and/or T1421, T1422 and/or T1428, T1429 and/or T1437, T1438, in each case together, may also form "heterocyclyl"; (2) "-C(O)-C(O)-T1445, -S(0 2 )-NT1446T1447'; 15 where T1445, T1446, T1447 are each independently selected from the group consisting of: (J) "hydrogen, alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1448, 20 NT1449T1450, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , C(O)-T1451, -C(O)O-T1452, -C(O)NH-T1453, C(O)NT1454T1455, -O-T1456, -O(-T1457-O)r-H (ru = 1, 2,3, 4, 5), -O(-T1458-O)n-T1459 (ru = 1, 2, 3,4, 5), -OC(O)-T1460, 25 -OC(O)-O-T1461, -OC(O)-NHT1462, -O-C(O)-NT1463T1464, -OP(O)(OT1465)(OT1466), -OSi(T1467)(T1468)(T1469), OS(0 2 )-T1470, -NHC(O)-T1471, -NT1472C(O)-T1473, -NH C(O)-O-T1474, -NH-C(O)-NH-T1475, -NH-C(O) NT1476T1477, -NT1478-C(O)-O-T1479, -NT1480-C(O)-NH 30 T1481, -NT1482-C(O)-NT1483T1484, -NHS(0 2 )-T1485, NT1486S(0 2 )-T1487, -S-T1488, -S(O)-T1489, -S(0 2 )-T1490, S(0 2 )NH-T1491, -S(0 2 )NT1492T1493, -S(0 2 )O-T1494, P(O)(OT1495)(OT1496), -Si(T1497)(T1498)(T1499)"; W02007/054556 PCT/EP2006/068322 -434 where T1448, T1449, T1450, T1451, T1452, T1453, T1454, T1455, Ti456, T1457, T1458, T1459, T1460, T1461, T1462, T1463, T1464, T1465, T1466, T1467,T1468, T1469, T1470, T1471, T1472, T1473, T1474, T1475, T1476, T1477, T1478, 5 T1479, T1480, T1481, T1482, T1483, T1484, T1485, T1486, T1487, T1488, T1489, T1490, T1491, T1492, T1493, T1494, T1495, T1496, T1497, T1498, T1499 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 10 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1454, T1455 and/or T1463, T1464 and/or T1476, T1477 and/or T1483, T1484 and/or T1492, T1493, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substitution group (I) 15 may each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, 20 Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHT1500, -NT1501T1502, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1503, -C(0)0 T1 504, -C(O)NH-T1 505, -C(O)NT1 506T1 507, -O-T1508, O(-T1509-0),-H (rv = 1, 2, 3, 4, 5), -O(-T1510-O),-T1511 25 (rv = 1, 2, 3, 4, 5), -OC(O)-T1512, -OC(O)-O-T1513, OC(O)-NHT1514, -O-C(O)-NT1515T1516, OP(O)(OT1517)(OT1518), -OSi(T1519)(T1520)(T1521), OS(0 2 )-T1522, -NHC(O)-T1523, -NT1524C(O)-T1525, NH-C(O)-O-T1526, -NH-C(O)-NH-Ti 527, -NH-C(O) 30 NT1528T1529, -NT1530-C(O)-O-T1531, -NT1532-C(O) NH-T1533, -NT1534-C(O)-NT1535T1536, -NHS(0 2 )-T1537, -NT1 538S(0 2 )-T1 539, -S-T1 540, -S(O)-T1 541, -S(02) T1542, -S(0 2 )NH-T1543, -S(0 2 )NT1544T1545, -S(02)0 T1 546, -P(O)(OT1 547)(OT1 548), -Si(T1 549)(T1 550)(T1 551)"; W02007/054556 PCT/EP2006/068322 -435 where T1500, T1501, T1502, T1503, T1504, T1505, T1506, T1507, T1508, T1509, Ti5lO, T1511, T1512, T1513, T1514, T1515, T1516, T1517, T1518, T1519, T1520, T1521, T1522, T1523, T1524, T1525, T1526, T1527, T1528, Ti529, T1530, 5 T1531, T1532, T1533, T1534, T1535, T1536, T1537, T1538, T1539, T1540, T1541, T1542, Ti543, T1544, T1545, T1546, T1 547, T1548, T1 549, T1 550, T1 551 are each independently selected from the group consisting of: "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl,

10. arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1506, T1507 and/or T1515, T1516 and/or T1528, T1529 and/or T1 535, T1536 and/or T1 544, T1 545, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group 15 (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 3 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, 20 F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1552, -NT1553T1554, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1555, C(0)O-T1 556, -C(O)NH-Ti 557, -C(O)NT1 558T1 559, O-T1560, -O(-T1561-0),-H (rw = 1, 2, 3, 4, 5), -O( 25 T1562-O)r-T1563 (rw = 1, 2, 3, 4, 5), -OC(O)-T1564, OC(O)-O-T1565, -OC(O)-NH T1566, -0-C(O) NT1 567T1 568, -OP(O)(OT1 569)(OT1 570), OSi(T1 571)(T1 572)(T1 573), -OS(0 2 )-T1 574, -NHC(O) T1 575, -NT1 576C(O)-Ti 577, -NH-C(O)-O-T1 578, -NH 30 C(O)-NH-T1579, -NH-C(O)-NT1580T1581, -NT1582 C(O)-O-T1 583, -NT1 584-C(O)-NH-Ti 585, -NT1 586 C(O)-NT1 587T1 588, -NHS(0 2 )-T1 589, -NT1 590S(0 2 ) T1 591, -S-T1 592, -S(O)-Ti 593, -S(0 2 )-T1 594, - W02007/054556 PCT/EP2006/068322 - 436 S(0 2 )NH-T1 595, -S(0 2 )NT1 596T1 597, -S(0 2 )O-T1 598, P(O)(OT1599)(OT1600), -Si(T1601)(T1602)(T1603)"; where T1552, T1553, T1554, T1555, T1556, T1557, T1558, T1559, T1560, T1561, T1562, T1563, T1564, 5 T1565, T1566, T1567, T1568, T1569,T1570, T1571, T1572, T1573, T1574, T1575, T1576, T1577, T1578, T1579, T1580, T1581, T1582, T1583, T1584, T1585, T1586, T1587, T1588, T1589, T1590, T1591, T1592, T1593, T1594, T1595, T1596, T1597, T1598, T1599, 10 T1600, T1601, T1602, T1603 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 558, T1559 and/or T1 567, T1 568 and/or 15 T1580, T1581 and/or T1587, T1588 and/or T1596, T1597, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently 20 from the group consisting of: (iii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , NHT1604, -NT1605T1606, -NO 2 , -OH, -OCF 3 , -SH, 25 O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , SO 3 H, -P(O)(OH) 2 , -C(O)-T1 607, -C(O)O-T1608, C(O)NH-T1609, -C(O)NT1610T1611, -O-T1612, -O( T1613-O)rk-H (rx = 1, 2, 3, 4, 5), -O(-T1614-O), T1615 (rx = 1, 2, 3, 4, 5), -OC(O)-T1616, -OC(O)-O 30 T1617, -OC(O)-NHT1618, -O-C(O)-NT1619T1620, OP(O)(OT1 621)(OT1 622), OSi(T1 623)(T1624)(T1 625), -OS(0 2 )-T1 626, NHC(O)-T1627, -NT1628C(O)-T1629, -NH-C(O)-O T1630, -NH-C(O)-NH-T1631, -NH-C(O)- W02007/054556 PCT/EP2006/068322 -437 NT1 632T1 633, -NT1634-C(O)-O-T1635, -NT1636 C(O)-NH-T1637, -NT1638-C(O)-NT1639T1640, NHS(0 2 )-T1641, -NT1642S(0 2 )-T1643, -S-T1644, S(O)-T1645, -S(0 2 )-T1646, -S(0 2 )NH-T1647, 5 S(O2)NT1648T1649, -S(0 2 )O-T1650, P(O)(OT1651)(OT1652), -Si(T1653)(T1654)(T1655)"; where T1604, T1605, T1606, T1607, T1608, T1609, T1610, T1611, Ti612, T1613, T1614, T1615, T1616, T1617, T1618, T1619, T1620, T1621, T1622, T1623, 10 T1624,T1625, T1626, T1627, T1628,T1629, T1630, T1631, T1632, T1633, T1634, T1635,T1636, T1637, T1638, T1639, T1640, T1641, T1642, T1643, T1644, T1645, T1646, T1647, T1648, T1649, T1650, T1651, T1652, T1653, T1654, T1655 are each independently 15 selected from the group consisting of: "alkyl, (C9 C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1610, T1611 and/or T1619, T1 620 and/or T1 632, T1633 and/or 20 T1639, T1640 and/or T1648, T1649, in each case together, may also form "heterocyclyl"; where, alternatively, T1446, T1447 together may also form "heterocyclyl"; 25 (3) "-C(Y8)NZ43Z44, -C(=NZ45)-Z46, -C(Y9)NZ47-Y10-Z48"; where Y8, Y9, Y10 are each independently selected from the group consisting of "0, S, =NH, =NZ49" where the Z43, Z44, Z45, Z46, Z47, Z48, Z49 radicals are each independently selected from the group consisting of: 30 (1) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O)-alkyl, -C(O)-(C9-C 30 )alkyl, -C(O) cycloalkyl, -C(O)-cycloalkylalkyl, -C(O)-aryl, -C(O)-arylalkyl, - W02007/054556 PCT/EP2006/068322 -438 C(O)-heteroaryl, -C(O)-heteroarylalkyl, -C(O)-heterocyclyl, C(O)-heterocyclylalkyl, -S(0 2 )-alkyl, -S(0 2 )-(C9-C 3 0 )alkyl, S(0 2 )-cycloalkyl, -S(0 2 )-cycloalkylalkyl, -S(0 2 )-aryl, -S(0 2 ) arylalkyl, -S(0 2 )-heteroaryl, -S(0 2 )-heteroarylalkyl, -S(0 2 ) 5 heterocyclyl, -S(0 2 )-heterocyclylalkyl"; where, optionally, the above substituents of substituent group (1) may also each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1656, -NT1657T1658, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T1659, -C(0)0 15 T1660, -C(O)NH-T1661, -C(O)NT1662T1663, -O-T1664, O(-T1665-O)r,-H (ry = 1, 2, 3, 4, 5), -O(-T1 666-O),-T1 667 (ry = 1, 2, 3, 4, 5), -OC(O)-T1668, -OC(O)-O-T1669, OC(O)-NHT1670, -O-C(O)-NT1671T1672, OP(O)(OT1673)(OT1674), -OSi(T1675)(T1676)(T1677), 20 OS(0 2 )-T1678, -NHC(O)-T1679, -NT1680C(O)-TI681, NH-C(O)-O-T1682, -NH-C(O)-NH-T1683, -NH-C(O) NT1 684T1 685, -NT1 686-C(O)-O-T1 687, -NT1 688-C(O) NH-T1689, -NT1690-C(O)-NT1691T1692, -NHS(0 2 )-T1693, -NT1694S(0 2 )-T1695, -S-T1696, -S(O)-T1697, -S(02) 25 T1698, -S(0 2 )NH-T1699, -S(0 2 )NT1700T1701, -S(O2)O T1 702, -P(O)(OT1 703)(OT1 704), -Si(T1 705)(T1 706)(T1 707)"; where T1656, T1657, T1658, T1659, T1660, T1661, T1662, T1663, T1664, T1665, Ti666, T1667, Ti668, Ti669, T1670, T1671, Ti672, Ti673, T1674, T1675, T1676, Ti677, Ti678, 30 T1679, T1680, T1681, T1682, Ti683, Ti684, T1685, T1686, T1687, T1688, T1689, T1690, T1691, T1692, T1693, Ti694, T1695, Ti696, T1697, T1698, T1699, T1700, T170, T1702, T1703, T1704, T1705, T1706, T1707 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, W02007/054556 PCT/EP2006/068322 - 439 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1662, T1663 and/or T1671, TI672 and/or T1684, T1685 and/or T1691, T1692 and/or T1700, T1701, in each case 5 together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may also in turn each independently be further substituted by at least one substituent selected identically or differently from the group consisting of: 10 (ii) "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, I, CN, CF 3 , N 3 , NH 2 , -NHT1708, -NT1709T1710, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-T171 1, 15 C(O)O-T1712, -C(O)NH-T1713, -C(O)NT1714T1715, 0-T1716, -0(-T1717-O)r-H (rz = 1, 2, 3, 4, 5), -O( T1718-O)r-T1719 (rz = 1, 2, 3, 4, 5), -OC(O)-T1 720, OC(O)-O-T1721, -OC(0)-NHT1722, -O-C(0) NT1 723T1 724, -OP(O)(OT1 725)(OT1 726), 20 OSi(T1 727)(T1 728)(T1 729), -OS(0 2 )-T1 730, -NHC(O) T1731, -NT1732C(O)-T1733, -NH-C(O)-O-T1734, -NH C(O)-NH-Ti 735, -NH-C(0)-NT1 736T1 737, -NT1 738 C(O)-O-T1 739, -NT1 740-C(O)-NH-T 741, -NT1 742 C(O)-NT1 743T1 744, -NHS(0 2 )-T1 745, -NT1 746S(02) 25 T1 747, -S-T1 748, -S(O)-Ti 749, -S(0 2 )-T1 750, S(0 2 )NH-T1 751, -S(0 2 )NT1 752T1 753, -S(0 2 )O-T1 754, P(O)(OT1 755)(OT1 756), -Si(T1 757)(T1 758)(T1 759)"; where T1708, T1 709, T1710, T1711, T1712, T1713, T1714, T1715, T1716, T17i7, T17i8, T17i9, Ti720, 30 T1721, Ti722, T1723, T1724, Ti725, T1726, T1727, T1728, T1729, T1730,T1731, T1732, Ti733, T1734, T1735, Ti736, T1737, T1738, T1739, T1740, Ti741, T1742, T1743, T1744, Ti745, T1746, T1747, T1748, T1749, T1750, T1751, T1752, T1753, T1754, T1755, W02007/054556 PCT/EP2006/068322 - 440 T1756, T1 757, T1 758, T1 759 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, 5 alternatively, T1714, T1715 and/or T1723, T1724 and/or T1736, T1737 and/or T1743, T1744 and/or T1752, T1753, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by 10 at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , 15 NHT1760, -NT1761T1762, -NO 2 , -OH, -OCF 3 , -SH, O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , SO 3 H, -P(O)(OH) 2 , -C(O)-T1763, -C(O)O-T1764, C(O)NH-T1 765, -C(O)NT1 766T1 767, -O-T1 768, -O( T1769-0),-H (ra = 1, 2, 3, 4, 5), -O(-T1770-0), 20 T1771 (ra = 1, 2, 3, 4, 5), -OC(O)-T1772, -OC(O)-O T1773, -OC(O)-NHT1774, -O-C(O)-NT1775T1776, OP(O)(OT1 777)(OT1778), OSi(T1 779)(T1 780)(T1 781), -OS(0 2 )-T1 782, NHC(O)-T1783, -NT1784C(O)-T1785, -NH-C(O)-O 25 T1 786, -NH-C(O)-NH-T1 787, -NH-C(O) NT1 788T1 789, -NT1 790-C(O)-O-T1 791, -NT1 792 C(O)-NH-Ti 793, -NT1 794-C(O)-NT1 795T1 796, NHS(0 2 )-T1797, -NT1798S(O 2 )-T1799, -S-T1800, S(O)-T1801, -S(0 2 )-T1802, -S(0 2 )NH-T1803, 30 S(0 2 )NT1804T1805, -S(0 2 )O-T1806, P(O)(OT1 807)(OT1 808), -Si(T1 809)(T1 81 0)(T1 811)"; where T1760, T1761, T1762, T1763, T1764, T1765, T1766, T1767, T1768,T1769, T1770, T1771, T1772, T1773, T1774, T1775,T1776, T1777, T1778, T1779, W02007/054556 PCT/EP2006/068322 -441 T1780, T1781, T1782, T1783, T1784, T1785, T1786, T1787, T1788, T1789, T1790, T1791, T1792, T1793, T1794, T1795, T1796, T1797, T1798, T1799, T1800, T1801, T1802, T1803, T1804, T1805, T1806, T1807, 5 T1808, T1809, T1810, T1811 are each independently selected from the group consisting of: "alkyl, (C 9 C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, T1 766, T1 767 10 and/or T1775, T1776 and/or T1788, T1789 and/or T1795, T1796 and/or T1804, T1805, in each case together, may also form "heterocyclyl"; and 15 the Z3, Z4 radicals are each independently selected from the group consisting of: (e) hydrogen; (f) halogen, F, Cl, Br, 1; 20 (g) unsubstituted or substituted alkyl or (C 9 -C 30 )alkyl, where, optionally, the alkyl or (C 9 -C 30 )alkyl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, 25 CN, CF 3 , N 3 , NH 2 , -NHB457, -NB458B459, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-B460, -C(O)O-B461, -C(O)NH-B462, C(O)NB463B464, -O-B465, -O(-B466-O),-H (x = 1, 2, 3, 4, 5), -O( B467-0),-B468 (x = 1, 2, 3, 4, 5), -OC(O)-B469, -OC(O)-O-B470, 30 OC(O)-NHB471, -O-C(O)-NB472B473, -OP(O)(OB474)(OB475), OSi(B476)(B477)(B478), -OS(0 2 )-B479, -NHC(O)-B480, NB481C(O)-B482, -NH-C(O)-O-B483, -NH-C(O)-NH-B484, -NH- W02007/054556 PCT/EP2006/068322 - 442 C(O)-NB485B486, -NB487-C(O)-O-B488, -NB489-C(O)-NH B490, -NB491-C(O)-NB492B493, -NHS(0 2 )-B494, -NB495S(0 2 ) B496, -S-B497, -S(O)-B498, -S(0 2 )-B499, -S(O 2 )NH-B500, S(0 2 )NB501 B502, -S(0 2 )O-B503, -P(O)(OB504)(OB505), 5 Si(B506)(B507)(B508)"; where B457, B458, B459, B460, B461, B462, B463, B464, B465, B466, B467, B468, B469, B470, B471, B472, B473, B474, B475, B476, B477, B478, B479, B480, B481, B482, B483, B484, B485, B486, B487, B488, B489, B490, B491, B492, B493, B494, B495, 10 B496, B497, B498, B499, B500, B501, B502, B503, B504, B505, B506, B507, B508 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B463, B464 and/or B472, 15 B473 and/or B485, B486 and/or B492, B493 and/or B501, B502, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 20 (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB509, -NB510B511, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B512, -C(O)O-B513, -C(O)NH 25 B514, -C(O)NB515B516, -0-B517, -O(-B518-)y-H (y = 1, 2, 3, 4, 5), -O(-B519-O)y-B520 (y = 1, 2, 3, 4, 5), -OC(0)-B521, OC(O)-O-B522, -OC(O)-NHB523, -0-C(O)-NB524B525, OP(O)(OB526)(OB527), -OSi(B528)(B529)(B530), -OS(0 2 ) B531, -NHC(O)-B532, -NB533C(O)-B534, -NH-C(O)-O-B535, 30 -NH-C(O)-NH-B536, -NH-C(O)-NB537B538, -NB539-C(O)-O B540, -NB541-C(O)-NH-B542, -NB543-C(O)-NB544B545, NHS(0 2 )-B546, -NB547S(0 2 )-B548, -S-B549, -S(O)-B550, S(0 2 )-B551, -S(0 2 )NH-B552, -S(0 2 )NB553B554, -S(0 2 )O B555, -P(O)(OB556)(OB557), -Si(B558)(B559)(B560)"; W02007/054556 PCT/EP2006/068322 - 443 where B509, B510, B511, B512, B513, B514, B515, B516, B517, B518, B519, B520, B521, B522, B523, B524, B525, B526, B527, B528, B529, B530, B531, B532, B533, B534, B535, B536, B537, B538, B539, B540, B541, B542, B543, B544, B545, B546, B547, 5 B548, B549, B550, B551, B552, B553, B554, B555, B556, B557, B558, B559, B560 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B515, B516 and/or B524, 10 B525 and/or B537, B538 and/or B544, B545 and/or B553, B554, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 15 consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF3, N 3 , NH 2 , -NHB561, -NB562B563, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, 20 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B564, -C(O)O-B565, C(O)NH-B566, -C(O)NB567B568, -O-B569, -O(-B570-O)f H (z = 1, 2, 3, 4, 5), -O(-B571-O)z-B572 (z = 1, 2, 3, 4, 5), OC(O)-B573, -OC(O)-O-B574, -OC(O)-NHB575, -O-C(0) NB576B577, -OP(O)(OB578)(OB579), 25 OSi(B580)(B581)(B582), -OS(0 2 )-B583, -NHC(O)-B584, NB585C(O)-B586, -NH-C(O)-O-B587, -NH-C(O)-NH B588, -NH-C(O)-NB589B590, -NB591-C(O)-O-B592, NB593-C(O)-NH-B594, -NB595-C(O)-NB596B597, NHS(0 2 )-B598, -NB599S(0 2 )-B600, -S-B601, -S(O)-B602, 30 -S(0 2 )-B603, -S(0 2 )NH-B604, -S(0 2 )NB605B606, -S(0 2 )O B607, -P(O)(OB608)(OB609), -Si(B610)(B61 1)(B612)"; where B561, B562, B563, 8564, B565, B566, B567, B568, B569, B570, B571, B572, B573, B574, B575, B576, B577, B578, B579, B580, B581, B582, B583, B584, B585, B586, W02007/054556 PCT/EP2006/068322 -444 B587, B588, B589, B590, B591, B592, B593, B594, B595, B596, B597, B598, B599, B600, B601, B602, B603, B604, B605, B606, B607, B608, B609, B610, B611, B612 are each independently selected from the group consisting of: "alkyl, 5 (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B567, B568 and/or B576, B577 and/or B589, B590 and/or B596, B597 and/or B605, B606, in each case together, may also form "heterocyclyl"; 10 (h) unsubstituted or substituted aryl where, optionally, the aryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB613, -NB614B615, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-B616, -C(0)0-8617, -C(O)NH-B618, C(O)NB619B620, -0-B621, -O(-B622-0)-H (a = 1, 2, 3, 4, 5), -O( 20 B623-O)a-B624 (a = 1, 2, 3, 4, 5), -OC(O)-B625, -OC(O)-O-B626, OC(O)-NHB627, -O-C(O)-NB628B629, -OP(O)(OB630)(OB631), OSi(B632)(B633)(B634), -OS(0 2 )-B635, -NHC(O)-B636, NB637C(O)-B638, -NH-C(O)-O-B639, -NH-C(O)-NH-B640, -NH C(O)-NB641B642, -NB643-C(O)-O-B644, -NB645-C(O)-NH 25 B646, -NB647-C(O)-NB648B649, -NHS(0 2 )-B650, -NB651 S(0 2 ) B652, -S-B653, -S(O)-B654, -S(0 2 )-B655, -S(0 2 )NH-B656, S(0 2 )NB657B658, -S(0 2 )O-B659, -P(O)(OB660)(OB661), Si(B662)(B663)(B664)"; where B613, 8614, B615, B616, B617, B618, B619, B620, B621, 30 B622, B623, B624, B625, B626, B627, B628,B629, B630, B631, B632, B633, B634, B635, B636, B637, B638, B639, B640, B641, B642, B643, B644, B645, B646, B647,8648,B649, B650, B651, B652, B653, B654, B655, B656, B657, B658, B659, B660, B661, W02007/054556 PCT/EP2006/068322 - 445 B662, B663, B664 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B619, B620 and/or B628, 5 B629 and/or B641, B642 and/or B648, B649 and/or B657, B658, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 10 (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHB665, -NB666B667, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B668, -C(O)O-B669, -C(O)NH 15 B670, -C(O)NB671B672, -O-B673, -O(-B674-O)b-H (b = 1, 2, 3, 4, 5), -O(-B675-O)b-B676 (b = 1, 2, 3, 4, 5), -OC(O)-B677, OC(O)-O-B678, -OC(O)-NHB679, -0-C(O)-NB680B681, OP(O)(OB682)(OB683), -OSi(B684)(B685)(B686), -OS(0 2 ) B687, -NHC(O)-B688, -NB689C(O)-B690, -N H-C(O)-O-B691, 20 -NH-C(O)-NH-B692, -NH-C(O)-NB693B694, -NB695-C(O)-O 6696, -NB697-C(O)-NH-B698, -NB699-C(O)-NB700B701, NHS(0 2 )-B702, -NB703S(0 2 )-B704, -S-B705, -S(O)-B706, S(0 2 )-B707, -S(0 2 )NH-B708, -S(0 2 )NB709B710, -S(0 2 )O B71 1, -P(O)(OB712)(OB713), -Si(B714)(B715)(B716)"; 25 where B665, B666, B667, B668, B669, B670, B671, B672, B673, B674, B675, B676, B677, B678, B679, B680, B681, B682, B683, B684, B685, B686, B687, B688, B689, B690, B691, B692, B693, 8694, B695,8696, B697, B698, B699, B700, B701, B702, B703, B704, B705, B706, B707, B708, B709, 6710, B711, B712, B713, 30 B714, B715, B716 are each independently selected from the group consisting of: "alkyl, (C9-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B671, B672 and/or B680, W02007/054556 PCT/EP2006/068322 - 446 B681 and/or B693, B694 and/or B700, B701 and/or B709, B710, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one 5 substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB717, -NB718B719, -NO 2 , 10 OH, -OCF 3 , -SH, -0-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B720, -C(O)O-B721, C(O)NH-B722, -C(O)NB723B724, -0-B725, -O(-B726-0)c H (c = 1, 2, 3, 4, 5), -O(-B727-O)e-B728 (c = 1, 2, 3, 4, 5), OC(O)-B729, -OC(O)-0-B730, -OC(O)-NHB731, -0-C(O) 15 NB732B733, -OP(O)(OB734)(OB735), OSi(B736)(B737)(B738), -OS(0 2 )-B739, -NHC(O)-B740, NB741 C(O)-B742, -NH-C(O)-O-B743, -NH-C(O)-NH B744, -NH-C(O)-NB745B746, -NB747-C(O)-O-B748, NB749-C(O)-NH-B750, -NB751-C(O)-NB752B753, 20 NHS(0 2 )-B754, -NB755S(0 2 )-B756, -S-B757, -S(O)-B758, -S(0 2 )-B759, -S(0 2 )NH-B760, -S(0 2 )NB761B762, -S(0 2 )O B763, -P(O)(OB764)(OB765), -Si(B766)(B767)(B768)"; where B717, B718, B719, B720, B721, B722, B723, B724, 8725, B726, B727, 8728, B729, B730, B731, B732, B733, 25 B734, B735, B736, B737, B738, B739, B740, B741, B742, B743, B744, B745, B746, B747, B748, B749, B750, B751, B752, B753, B754, B755, B756, B757, B758, B759, B760, B761, B762, B763, B764, B765, B766, B767, B768 are each independently selected from the group consisting of: alkyll, 30 (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B723, B724 and/or B732, B733 and/or B745, B746 and/or B752, B753 and/or B761, B762, in each case together, may also form "heterocyclyl"; W02007/054556 PCT/EP2006/068322 - 447 (j) unsubstituted or substituted heteroaryl where, optionally, the heteroaryl radical may be substituted by at least one substituent selected identically or differently from the group consisting of: 5 (ii) "alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB769, -NB770B771, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-B772, -C(O)O-B773, -C(O)NH-B774, 10 C(O)NB775B776, -0-B777, -O(-B778-O)d-H (d = 1, 2, 3, 4, 5), -O( B7 7 9 -O)d-B 780 (d = 1, 2, 3, 4, 5), -OC(O)-B781, -OC(O)-O-8782, OC(O)-NHB783, -O-C(O)-NB784B785, -OP(O)(OB786)(OB787), OSi(B788)(B789)(B790), -OS(0 2 )-B791, -NHC(O)-B792, NB793C(O)-B794, -NH-C(O)-O-B795, -NH-C(O)-NH-B796, -NH 15 C(O)-NB797B798, -NB799-C(O)-O-B800, -NB801-C(O)-NH B802, -NB803-C(O)-NB804B805, -NHS(0 2 )-B806, -NB807S(0 2 ) B808, -S-B809, -S(O)-B810, -S(0 2 )-B811, -S(0 2 )NH-B812, S(0 2 )NB813B814, -S(0 2 )O-B815, -P(O)(OB816)(OB817), Si(B818)(B819)(B820)"; 20 where B769, B770, B771, B772, B773, B774, B775, B776, B777, B778, B779, B780, B781, B782, B783, B784, B785, B786, B787, B788, B789, B790, B791, B792, B793, B794, B795, B796, B797, B798, B799, B800, B801, B802, B803, B804, B805, B806, B807, B808, B809, B810, B811, B812, B813, B814, B815, B816, B817, 25 B818, B819, B820 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B775, B776 and/or B784, 8785 and/or B797, B798 and/or B804, B805 and/or B813, B814, in 30 each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 - 448 (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB821, -NB822B823, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , 5 -SO 3 H, -P(O)(OH) 2 , -C(O)-B824, -C(O)O-B825, -C(O)NH B826, -C(O)NB827B828, -O-B829, -0(-B830-0),-H (e = 1, 2, 3, 4, 5), -O(-B831-0).-B832 (e = 1, 2, 3, 4, 5), -OC(O)-B833, OC(O)-O-B834, -OC(O)-NHB835, -0-C(O)-NB836B837, OP(O)(OB838)(OB839), -OSi(B840)(B841)(B842), -OS(0 2 ) 10 B843, -NHC(O)-B844, -NB845C(O)-B846, -NH-C(O)-O-B847, -NH-C(O)-NH-B848, -NH-C(O)-NB849B850, -NB851-C(O)-O B852, -NB853-C(O)-NH-B854, -NB855-C(O)-NB856B857, NHS(0 2 )-B858, -NB859S(0 2 )-B860, -S-B861, -S(O)-B862, S(0 2 )-B863, -S(O 2 )NH-B864, -S(0 2 )NB865B866, -S(0 2 )O 15 B867, -P(O)(0B868)(OB869), -Si(B870)(B871)(B872)"; where B821, B822, B823, B824, B825, B826, B827, B828, B829, B830, B831, B832, B833, B834, B835, B836, B837, B838, B839, B840, B841, B842, B843, B844, B845, B846, B847, B848, B849, B850, B851, B852, B853, B854, B855, B856, B857, B858, B859, 20 B860, B861, B862, B863, B864, B865, B866, B867, B868, B869, B870, B871, B872 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B827, B828 and/or B836, 25 B837 and/or B849, B850 and/or B856, B857 and/or B865, B866, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group 30 consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB873, -NB874B875, -NO 2 , OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, - W02007/054556 PCT/EP2006/068322 - 449 C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B876, -C(0)0-8877, C(O)NH-B878, -C(O)NB879B880, -0-B881, -O(-B882-0)r H (f = 1, 2, 3, 4, 5), -O(-B883-O)f-B884 (f = 1, 2, 3, 4, 5), OC(O)-B885, -OC(O)-O-B886, -OC(O)-N H B887, -0-C(O) 5 NB888B889, -OP(O)(OB890)(OB891), OSi(B892)(B893)(B894), -OS(0 2 )-B895, -NHC(O)-B896, NB897C(O)-B898, -NH-C(O)-O-B899, -NH-C(O)-NH B900, -NH-C(O)-NB9O1B902,--NB903-C(O)-O-B904, NB905-C(O)-NH-B906, -NB907-C(O)-NB908B909, 10 NHS(0 2 )-B91 0, -NB91 1 S(0 2 )-B912, -S-B913, -S(O)-B914, -S(0 2 )-B915, -S(0 2 )NH-B916, -S(0 2 )NB917B918, -S(0 2 )O B919, -P(O)(OB920)(OB921), -Si(B922)(B923)(B924)"; where B873, B874, B875, B876, B877, B878, B879, B880, B881, B882, B883, B884, B885, B886, B887, B888, B889, 15 B890, B891, B892, B893, B894, B895, B896, B897, B898, B899, B900, B901, B902, B903, B904, B905, B906, B907, B908, B909, B910, B911, B912, B913, B914, B915, B916, B917, B918, B919, B920, B921, B922, B923, B924 are each independently selected from the group consisting of: "alkyl, 20 (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B879, B880 and/or B888, B889 and/or B901, B902 and/or B908, B909 and/or B917, B918, in each case together, may also form "heterocyclyl"; 25 (k) OZ6 where Z6 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 3 0 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 30 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, W02007/054556 PCT/EP2006/068322 -450 Br, I, CN, CF 3 , N 3 , NH 2 , -NHB925, -NB926B927, -NO 2 , -OH, OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B928, -C(O)O-B929, -C(O)NH B930, -C(O)NB931 B932, -0-B933, -O(-B934-O)g-H (g = 1, 2, 3, 5 4, 5), -O(-B9 35 -O)g-B 9 36 (g = 1, 2, 3, 4, 5), -OC(O)-B937, OC(O)-O-B938, -OC(O)-NHB939, -O-C(O)-NB940B941, OP(O)(OB942)(OB943), -OSi(B944)(B945)(B946), -OS(0 2 ) B947, -NHC(O)-B948, -NB949C(O)-B950, -NH-C(O)-O-B951, -NH-C(O)-NH-B952, -NH-C(O)-NB953B954, -NB955-C(O)-O 10 B956, -NB957-C(O)-NH-B958, -NB959-C(O)-NB960B961, NHS(0 2 )-B962, -NB963S(0 2 )-B964, -S-B965, -S(O)-B966, S(0 2 )-B967, -S(0 2 )NH-B968, -S(0 2 )NB969B970, -S(0 2 )O B971, -P(O)(OB972)(OB973), -Si(B974)(B975)(B976)"; where B925, B926, B927, B928, B929, 8930, B931, B932, B933, 15 B934, B935, B936, B937, B938, B939, B940, B941, B942, B943, B944, B945, B946, B947, B948, B949, B950, B951, B952, B953, B954, B955, B956, B957, B958, B959, B960, B961, B962, B963, B964,B965, B966, B967, B968, B969, B970, B971, B972, B973, B974, B975, B976 are each independently selected from the group 20 consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B931, B932 and/or B940, B941 and/or B953, B954 and/or B960, B961 and/or B969, B970, in each case together, may also form "heterocyclyl"; 25 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 30 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB977, -NB978B979, -NO 2 , OH, -OCF 3 , -SH, -0-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B980, -C(O)O-B981, C(O)NH-B982, -C(O)NB983B984, -0-B985, -O(-B 9 8 6 -O)h- W02007/054556 -451- PCT/EP2006/068322 H (h = 1, 2, 3, 4, 5), -O(-B987-O)h-B 9 88 (h = 1, 2, 3, 4, 5), OC(O)-8989, -OC(O)-O-B990, -OC(O)-NHB991, -0-C(0) NB992B993, -OP(O)(OB994)(OB995), OSi(B996)(B997)(B998), -OS(0 2 )-B999, -NHC(O)-B1000, 5 NB1001C(0)-B1002, -NH-C(O)-O-B1003, -NH-C(O)-NH B1004, -NH-C(O)-NB1005B100 6 , -NB1007-C(O)-O-B1008, -NB1009-C(O)-NH-B1010, -NB1011-C(O)-NB1012B1013, NHS(02)-B1014, -NB1015S(0 2 )-B1016, -S-B1017, -S(O) B1018, -S(0 2 )-B1019, -S(0 2 )NH-B1020, 10 S(0 2 )NB1021B1022, -S(0 2 )O-B1023, P(O)(OB1024)(OB1025), -Si(B1026)(B1 027)(B1 028)"; where B977, B978, B979, B980, B981, B982, 8983, B984, B985, B986, B987, B988, B989, B990, B991, B992, B993, B994, B995, B996, B997, B998, B999, B1000, B1001, B1002, 15 B1003, B1004, B1005, B1006, B1007, B1008, B1009, B1010, B1011, B1012, B1013, B1014, B1015, B1016, B1017, B1018, B1019, B1020, B1021, B1022, B1023, B1024, B1025, B1026, B1027, B1028 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, 20 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, 8983, B984 and/or B992, B993 and/or B1005, B1006 and/or B1012, B1013 and/or B1021, B1022, in each case together, may also form "heterocyclyl"; 25 (1) SZ7 where Z7 is independently selected from the group consisting of: (ii) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl"; where, optionally, the above substituents of substituent group (i) may 30 in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, W02007/054556 -452- PCTIEP2006/068322 Br, 1, CN, CF 3 , N 3 , NH 2 , -NHB1029, -NB1030B1031, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B 1032, -C(O)O-B1033, C(O)NH-B1 034, -C(O)NB1035B1036, -0-B1037, -O(-B1038 5 O)rH (i = 1, 2,3,4,5), -O(-B10 39 -O)rB1040 (i = 1, 2, 3, 4, 5), OC(O)-B1041, -OC(O)-O-B1042, -OC(O)-NHB1043, -0-C(O) NB1044B1045, -OP(O)(OB1046)(0B1047), OSi(B1 048)(B1049)(B1 050), -OS(O 2 )-B1051, -NHC(O)-B1052, NB1053C(O)-B1054, -NH-C(O)-O-B1055, -NH-C(O)-NH 10 B1056, -NH-C(O)-NB1057B1058, -NB1059-C(O)-O-B1060, NB1061-C(O)-NH-B1062, -NB1063-C(O)-NB1064B1065, NHS(0 2 )-B1066, -NB1067S(O 2 )-B1068, -S-B1069, -S(O) B1070, -S(0 2 )-B1071, -S(0 2 )NH-B1072, -S(O 2 )NB1073B1074, S(0 2 )O-B1075, -P(O)(0B1076)(OB1077), 15 Si(B1078)(B1 079)(B1 080)"; where B1029, B1030, B1031, B1032, B1033, B1034, B1035, B1036, B1037, B1038, B1039, B1040, B1041, B1042, B1043, B1044, B1045, B1046, B1047, B1048, B1049, B1050, B1051, B1052, B1053, B1054, B1055, B1056, B1057, B1058, B1059, 20 B1060, B1061, B1062, B1063, B1064, B1065, B1066, B1067, B1068, B1069, B1070, B1071, B1072, B1073, B1074, B1075, B1076, B1077, B1078, B1079, B1080 are each independently selected from the group consisting of: "alkyl, (C 9 -C 3 )akyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, 25 arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1035, B1036 and/or B1044, B1045 and/or B1057, B1058 and/or B1064, B1065 and/or B1073, B1074, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) 30 may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, W02007/054556 PCT/EP20061068322 -453 Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHB1081, -NB1082B1083, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B1084, -C(0)0 B1085, -C(O)NH-B1086, -C(O)NB1087B1088, -O-B1089, 5 O(-B1090-O)j-H (j = 1, 2, 3, 4, 5), -O(-B1091-O)j-B10 92 ( = 1, 2,3, 4, 5), -OC(O)-B1093, -OC(O)-O-B1094. -OC(O) NHB1095, -O-C(O)-NB1096B1097, OP(O)(OB1098)(OB1 099), -OSi(B1100)(B1 101 )(B 1102), OS(O 2 )-B1103, -NHC(O)-B1104, -NB1105C(O)-B1106, 10 NH-C(O)-O-B 1107, -NH-C(O)-NH-B 1108, -NH-C(O) NB1109B1110, -NB1111-C(O)-O-B1112, -NB1113-C(O) NH-B1114, -NB1115-C(O)-NB1116B1117, -NHS(02) B1 118, -NB1 119S(O2)-B1 120, -S-11121, -S(O)-B1 122, S(0 2 )-B1123, -S(0 2 )NH-B1124, -S(0 2 )NB1125B1126, 15 S(0 2 )O-B1127, -P(O)(OB1128)(0B1129), Si(B1 130)(B1 131 )(B 1132)"; where B1081, B1082, B1083, B1084, B1085, B1086, B1087, B1088, B1089, B1090, B1091, B1092, B1093, B1094, B1095, B1096, B1097, B1098, B1099, B1100, B1101, B1102, B1103, 20 B1104, B1105, B1106, B1107, B1108, B1109, B110, B1111, B1112, B1113, B1114, B1115, B1116, B1117, B1118, B1119, B1120, B1121, B1122, B1123, B1124, B1125, B1126, B1127, B1128, B1129, B1130, B1131, B1132 are each independently selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, 25 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1087, B1088 and/or B1096, B1097 and/or B1109, 81110 and/or B1116, B1117 and/or B1125, B1 126, in each case together, may also form "heterocyclyl"; 30 (m) NZ8Z9 where Z8, Z9 are each independently selected from the group consisting of: W02007/054556 PCT/EP2006/068322 - 454 (ii) "hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, -C(O) B1133, -C(O)O-B1134, -C(O)-NB1135B1136, -S(02)-B1137, S(0 2 )O-B 1138"; 5 where B1133, B1134, B1135, B1136, B1137, B1138 are each independently selected from the group consisting of: hydrogen, alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1 135, B1 136 together may also form "heterocyclyl"; 10 where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (ii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, 15 Br, I, CN, CF 3 , N 3 , NH 2 , -NHB1 139, -NB1 140B1141, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B1 142, -C(O)O-B1 143, C(O)NH-B1 144, -C(O)NB1 145B1146, -0-B1147, -O(-B1 148 O)k-H (k = 1, 2, 3, 4, 5), -0(-B1149-O)k-B1150 (k = 1, 2, 3, 4, 5), 20 -OC(O)-B1151, -OC(O)-O-B1152, -OC(O)-NHB1153, -0 C(O)-NB1 154B1155, -OP(O)(OB 156)(OB1 157), OSi(B1 158)(B1159)(B1160), -OS(0 2 )-B1 161, -NHC(O)-B1 162, NB1 163C(O)-B1 164, -NH-C(O)-O-B1 165, -NH-C(O)-NH B1166, -NH-C(O)-NB1167B1168, -NB1169-C(O)-O-B1170, 25 NB1171-C(O)-NH-B1172, -NB1173-C(O)-NB1174B1175, NHS(0 2 )-B1176, -NB1177S(0 2 )-B1178, -S-B1179, -S(O) B1180, -S(0 2 )-B1181, -S(0 2 )NH-B1182, -S(0 2 )NB1183B1184, S(02)0-B1185, -P(O)(OB1 186)(OB1 187), Si(B1 188)(B1 189)(B1 190)"; 30 where B1139, B1140, B1141, B1142, B1143, B1144, B1145, B1146, B1147, 81148, 81149, B1150, B1l15, B1152, B1153, 81154, B1155, B1156, 81157, B1158, B1159, B1160, B1161, B1162, B1163, B1164, B1165, B1166, B1167, B1168, B1169, W02007/054556 -455- PCT/EP2006/068322 B1170, B1171, B1172, B1173, B1174, B1175, B1176, B1177, B1178, B1179, B1180, B1181, B1182, B1183, B1184, B1185, B1186, B1187, B1188, B1189, B1190 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, 5 cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1145, B1146 and/or B1154, B1155 and/or B1167, B1168 and/or B1174, B1175 and/or B1183, B1184, in each case together, may also form "heterocyclyl"; 10 where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 15 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHB1191, -NB1192B1193, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-B1 194, -C(0)0 B1 195, -C(O)NH-B1 196, -C(O)NB1197B31198, -O-B1 199, 20 O(-B1200-O)rH (I = 1, 2, 3, 4, 5), -O(-B1201-O)r-B120 2 (I = 1, 2, 3, 4, 5), -OC(O)-B1203, -OC(O)-O-B1204, -OC(O) NHB1205, -O-C(O)-NB1206B1207, OP(O)(OB1208)(OB1209), -OSi(B1210)(B1211)(B1 212), OS(O 2 )-B1213, -NHC(O)-B1214, -NB1215C(O)-B1216, 25 NH-C(O)-O-B1217, -NH-C(O)-NH-B1218, -NH-C(O) NB1219B1220, -NB1221-C(O)-O-B1222, -NB1223-C(O) NH-B1224, -NB1225-C(O)-NB1226B1227, -NHS(0 2 ) B1228, -NB1229S(0 2 )-B1230, -S-B1231, -S(O)-B1232, S(0 2 )-B1233, -S(0 2 )NH-B1234, -S(0 2 )NB1235B1236, 30 S(0 2 )O-B1 237, -P(O)(OB1238)(OB1239), Si(B1240)(B1241)(B1242)"; where B1191, B1192, B1193, B1194, B1195, B1196, B1197, B1198, B1199, B1200, B1201, B1202, B1203, B1204, B1205, B1206, B1207, B1208, B1209, B1210, B1211, B1212, B1213, W02007/054556 -456- PCT/EP2006/068322 B1214, B1215, B1216, B1217, B1218, B1219, B1220, B1221, B1222, B1223, B1224, B1225, B1226, B1227, B1228, B1229, B1230, B1231, B1232, B1233, B1234, B1235, B1236, B1237, B1238, B1239, B1240, B1241, B1242 are each independently 5 selected from the group consisting of: "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, B1197, B1198 and/or B1206, B1207 and/or B1219, B1220 and/or 81226, B1227 and/or B1235, B1236, in each case 10 together, may also form "heterocyclyl"; and the Z5 radical is independently selected from the group consisting of: 15 (i) "hydrogen, alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHD1, -ND2D3, -NO 2 , -OH, -OCF 3 , -SH, -O-SO 3 H, OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , -C(O)-D4, C(O)O-D5, -C(O)NH-D6, -C(O)ND7D8, -O-D9, -O(-D10-O),-H (r = 1, 2, 3, 20 4, 5), -0(-D11-0)r-D12 (r = 1, 2, 3, 4, 5), -OC(O)-D13, -OC(O)-O-D14, OC(O)-NHD15, -O-C(O)-ND16D17, -OP(O)(OD18)(OD19), OSi(D20)(D21)(D22), -OS(0 2 )-D23, -NHC(O)-D24, -ND25C(O)-D26, -NH C(O)-O-D27, -NH-C(O)-NH-D28, -NH-C(O)-ND29D30, -ND31-C(O)-O D32, -ND33-C(O)-NH-D34, -ND35-C(O)-ND36D37, -NHS(0 2 )-D38, 25 ND39S(0 2 )-D40, -S-D41, -S(O)-D42, -S(0 2 )-D43, -S(O 2 )NH-D44, S(0 2 )ND45D46, -S(0 2 )O-D47, -P(O)(OD48)(OD49), -Si(D50)(D51)(D52)"; where D1, D2, D3, D4, D5, D6, D7, D8, D9, D10, D11, D12, D13, D14, D15, D16, D17, D18, D19, D20, D21, D22, D23, D24, D25, D26, D27, D28, D29, D30, D31, D32, D33, D34, D35, D36, D37, D38, D39, D40, D41, D42, D43, 30 D44, D45, D46, D47, D48, D49, D50, D51, D52 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, D7, D8 and/or D16, D17 and/or D29, W02007/054556 PCT/EP2006/068322 - 457 D30 and/or D36, D37 and/or D45, D46, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (i) may in turn each independently be substituted by at least one substituent selected 5 identically or differently from the group consisting of: (ii) "alkyl, (Cg-C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, CI, Br, 1, CN, CF 3 , N 3 , NH 2 , -NHD53, -ND54D55, -NO 2 , -OH, -OCF 3 , -SH, -0 SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, -P(O)(OH) 2 , 10 C(O)-D56, -C(O)O-D57, -C(O)NH-D58, -C(O)ND59D60, -0-D61, -O( D62-O)s-H (s = 1, 2, 3, 4, 5), -O(-D 6 3 -O)r-D 6 4 (t = 1, 2, 3, 4, 5), OC(O)-D65, -OC(O)-O-D66, -OC(O)-NHD67, -0-C(O)-ND68D69, OP(O)(OD70)(OD71), -OSi(D72)(D73)(D74), -OS(0 2 )-D75, -NHC(O) D76, -ND77C(O)-D78, -NH-C(O)-O-D79, -NH-C(O)-NH-D80, -NH 15 C(O)-N D81D82, -ND83-C(O)-O-D84, -N D85-C(O)-N H-D86, -N D87 C(O)-ND88D89, -NHS(0 2 )-D90, -ND91S(O 2 )-D92, -S-D93, -S(O) D94, -S(0 2 )-D95, -S(0 2 )NH-D96, -S(0 2 )ND97D98, -S(0 2 )O-D99, P(O)(OD100)(OD101), -Si(D102)(D103)(D104)"; where D53, D54, D55, D56, D57, D58, D59, D60, D61, D62, D63, D64, 20 D65, D66, D67, D68, D69, D70, D71, D72, D73, D74, D75, D76, D77, D78, D79, D80, D81, D82, D83, D84, D85, D86, D87, D88, D89, D90, D91, D92, D93, D94, D95, D96, D97, D98, D99, D100, D101, D102, D103, D104 are each independently selected from the group consisting of: "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, 25 heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, D59, D60 and/or D68, D69 and/or D81, D82 and/or D88, D89 and/or D97, D98, in each case together, may also form "heterocyclyl"; where, optionally, the above substituents of substituent group (ii) may in turn each independently be substituted by at least one substituent 30 selected identically or differently from the group consisting of: (iii) "alkyl, (C 9 -C 30 )alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, F, Cl, Br, I, CN, CF 3 , N 3 , NH 2 , -NHD105, -ND106D107, -NO 2 , -OH, -OCF 3 , -SH, W02007/054556 PCT/EP2006/068322 - 458 -O-SO 3 H, -OP(O)(OH) 2 , -CHO, -COOH, -C(O)NH 2 , -SO 3 H, P(O)(OH) 2 , -C(O)-D108, -C(O)O-D109, -C(O)NH-D110, C(O)ND1 11 D1 12, -O-D113, -O(-D1 14-0)r-H (t = 1, 2, 3, 4, 5), -0( D115-O)r-D116 (t = 1, 2, 3, 4, 5), -OC(0)-D1 17, -OC(O)-O-D1 18, 5 OC(O)-NHD1 19, -0-C(O)-ND1 20D121, -OP(O)(OD1 22)(OD1 23), OSi(D1 24)(D1 25)(D1 26), -OS(0 2 )-Dl 27, -NHC(O)-D1 28, ND1 29C(O)-D130, -NH-C(O)-O-D131, -NH-C(O)-NH-D132, -NH C(O)-ND133D134, -ND135-C(O)-O-D136, -ND137-C(O)-NH D138, -ND139-C(O)-ND140D141, -NHS(0 2 )-D142, -ND143S(0 2 ) 10 D144, -S-D145, -S(O)-D146, -S(0 2 )-D147, -S(0 2 )NH-D148, S(0 2 )ND149D1 50, -S(0 2 )O-D1 51, -P(O)(OD1 52)(OD1 53), Si(D1 54)(D1 55)(D1 56)"; where D105, D106, D107, D108, D109, D110, D111, D112, D113, D114, D115, D116, D117, D118, D119, D120, D121, D122, D123, 15 D124, D125, D126, D127, D128, D129, D130, D131, D1 3 2 , D1 3 3 , D134, D135, D136, D137, D138, D139, D140, D141, D142, D143, D144, D145, D146, D147, D148, D149, D150, D151, D152, D153, D154, D155, D156 are each independently selected from the group consisting of: "alkyl, (Cg-C30)alkyl, cycloalkyl, cycloalkylalkyl, 20 heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl" and where, alternatively, D111, D112 and/or D120, D121 and/or D133, D134 and/or D140, D141 and/or D149, D150, in each case together, may also form "heterocyclyl". 25 2. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to Claim 1, where, in (A), the Z1 radical is independently "NZ14Z15"; where Z14 is hydrogen or "aryl" and Z15 is "-C(O)NH-alkyl"; where "-C(O)NH-alkyl" may additionally, optionally, be substituted by "-OH"; 30 the Z2 radical is independently hydrogen; the Z3 radical is independently "substituted aryl", where "substituted aryl" is substituted by at least one substituent selected identically or differently from the group consisting of: W02007/054556 PCT/EP2006/068322 - 459 (a) "alkyl, -OC(O)-alkyl, -0-alkyl, -NHC(O)-alkyl"; with the proviso that the above substituents of substituent group (a) are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: 5 (ci) "aryl, heterocyclyl, -O-alkyl-O-alkyl, -0-arylalkyl"; or the Z3 radical is independently "substituted aryl", where "substituted aryl" is substituted by at least one substituent selected identically or differently from the group consisting of: a. "-OC(O)-0-alkyl,-OC(O)-O-aryl, -OC(O)-N(alkyl)2, -OC(O)-N H 10 alkyl, -OC(O)-(Cg-C 30 )alkyl, -NHC(O)-O-alkyl, -NHC(O)-NH-alkyl, -NHC(O) N(alkyl) 2 , -Si(alkyl) 3 "; where, optionally, the above substituents of substituent group (c) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 15 (i) "-O-alkyl, -0-arylalkyl"; where, optionally, the Z3 radical may also independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "halogen, F, Cl, Br, I, -0-alkyl"; the Z4 radical is independently hydrogen; 20 the Z5 radical is independently hydrogen. 3. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to one of Claims 1, 2, where, in (A), the Z1 radical is independently selected from the group consisting of "-NHC(O)NH 25 ethyl, -NHC(O)NH-butyl-OH"; the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "4-phenyl methyl carbonate, 3-phenyl 2-methoxyethyl carbonate, 4-phenyl 2-methoxyethyl carbonate, 4-phenyl phenyl carbonate, 4-phenyl N-diethylcarbamate, 4-phenyl 3 30 phenylacrylate, 4-phenyl nonadecanoate, 4-phenyl isobutyl carbonate, 4-phenyl W02007/054556 PCT/EP2006/068322 -460 but-2-ynyl carbonate, 4-phenyl N-dimethylcarbamate, 4-phenyl N-ethylcarba mate, tert-butyl N-(4-phenyl)carbamate, 2-methoxyethyl N-(4-phenyl)carbamate, 4-(3 ethylurea)phenyl, 4-(3,3-methylurea)phenyl, 4-morpholin-4-ylmethylphenyl, 4-{2-(2 methoxyethoxy)ethoxy]phenyl, N-(4-phenyl)-2-(2-methoxyethoxy)acetamide, 4-(2 5 methoxy)phenyl 2-methoxyethyl carbonate, 4-phenyl 2-benzyloxyethyl carbonate, 4-(2-methoxy)phenyl 2-benzyloxyethyl carbonate, N-(4-phenyl)-2 benzyloxyacetamide, 3-trimethylsilanylphenyl, 4-(2-methoxy)phenyl N diethylcarbamate, 4-(2-chloro-6-methoxy)phenyl N-diethylcarbamate, 4-(2 methoxy)phenyl 2-[2-(2-methoxyethoxy)ethoxy]ethyl carbonate"; 10 the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 4. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to Claim 1, where, in (B), 15 the Z1 radical is independently "NZ14Z15"; where Z14 is hydrogen and Z15 is C(O)NH-alkyl"; the Z2 radical is independently hydrogen; the Z3 radical is independently "substituted heteroaryl", where "substituted heteroaryl" is substituted by at least one substituent selected identically or 20 differently from the group consisting of: (a) "-NHC(O)-NH-alkyl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 25 5. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to one of Claims 1, 4, where, in (B), the Z1 radical is independently selected from the group consisting of "-NHC(O)NH ethyl"; the Z2 radical is independently hydrogen; W02007/054556 PCT/EP2006/068322 - 461 the Z3 radical is independently selected from the group consisting of "6-(3 ethylurea)pyridin-3-yl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 5 6. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to Claim 1, where, in (C), the Z1 radical is independently "NZ14Z15"; where Z14 is hydrogen and Z15 is C(O)NH-alkyl"; 10 the Z2 radical is independently hydrogen; the Z3 radical is independently "substituted alkyl", where "substituted alkyl" is substituted by at least one substituent selected identically or differently from the group consisting of: (a) "aryl, heteroaryl, cycloalkyl, -N(alkyl) 2 , -0-alkyl"; 15 where, optionally, the above substituents of substituent group (a) may in turn each independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "halogen, F, Cl, Br, I"; the Z4 radical is independently hydrogen; 20 the Z5 radical is independently hydrogen. 7. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to one of Claims 1, 6, where, in (C), the Z1 radical is independently selected from the group consisting of "-NHC(O)NH 25 ethyl"; the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "phenylethynyl, thiophen-3-ylethynyl, cyclopropylethynyl, N-dimethylaminoprop-1- W02007/054556 PCT/EP2006/068322 - 462 ynyl, 2-cyclohexylvinyl, 3-methoxypropenyl, benzyl, 2-(4-fluorophenyl)ethyl, 2-(4 fluorophenyl)vinyl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 5 8. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (I) according to Claim 1, where, in (D), the Z1 radical is independently "NZ14Z15"; where Z14 is hydrogen and Z15 is C(O)NH-alkyl"; 10 the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of: (1) "-NZ1OZ11"; where the Z10, Z11 radicals are each independently selected from the group consisting of: 15 (a) "hydrogen, aryl"; with the proviso that the above substituents of substituent group (a), when they are not hydrogen, are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: 20 (i) "cycloalkyl, heteroaryl, heterocyclylalkyl, -S(O) 2 -alkyl, -NH-S(O) 2 -alkyl, -C(O)NH-alkyl, -NH-C(O)-alkyl, -C(O)O-alkyl"; (b) "-C(O)-aryl"; where, optionally, the above substituents of substituent group (a) and/or substituent group (b) may each independently be substituted by at least one 25 substituent selected identically or differently from the group consisting of: (i) alkyll"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. W02007/054556 -463- PCT/EP2006/068322 9. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to one of Claims 1, 8, where, in (D), the Z1 radical is independently selected from the group consisting of "-NHC(O)NH ethyl"; 5 the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "4 methylbenzamide, 4-cyclohexylphenylamino, 4-methanesulphonylphenylamino, 3 (N-methanesulphonamide)-4-methylphenylamino, 3-N-methylbenzamideamino, 4 piperidin-1-ylmethylphenylamino, 4-thiophen-3-ylphenylamino, 4-N 10 acetamidophenylamino, 3-(ethyl benzoate)amino"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. 10. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to 15 Claim 1, where, in (E), the Z1 radical is independently selected from the group consisting of: (a) "NZ24Z25"; where Z24 is hydrogen and Z25 is "-C(O)-C(O)-O-alkyl" or " C(O)-C(O)-NH-alkyl" or "-C(O)-NH-0-alkyl"; where, optionally, the above substituents of substituent group (a) may each 20 independently be substituted by at least one substituent selected identically or differently from the group consisting of: (i) "-OSi(alkyl) 3 , -OC(O)-NH-alkyl, -OC(O)-O-alkyl, -P(O)(0-alkyl) 2 , P(O)(OH) 2 , -0-alkyl"; where, optionally, the above substituents of substituent group (i) may also 25 each independently be substituted further by at least one substituent selected identically or differently from the group consisting of: (ii) "heterocyclyl, OH, -N(alkyl) 2 , -OC(O)-alkyl"; where, optionally, the above substituents of substituent group (ii) may also each independently be substituted further by at least one W02007/054556 -464- PCT/EP2006/068322 substituent selected identically or differently from the group consisting of: (iii) "alkyl"; (b) "NZ26Z27"; where Z26 is hydrogen and Z27 is "-C(O)-NH-alkyl"; 5 with the proviso that the above substituents of substituent group (b) are each independently substituted further by at least one substituent selected identically or differently from the group consisting of: (i) "-OSi(alkyl) 3 , -OC(O)-NH-alkyl, -OC(O)-O-alkyl, -P(O)(0-alkyl) 2 , P(O)(OH) 2 , -0-alkyl"; 10 where, optionally, the above substituents of substituent group (i) may also each independently be substituted further by at least one substituent selected identically or differently from the group consisting of: (ii) "heterocyclyl, OH, -N(alkyl) 2 , -OC(O)-alkyl"; where, optionally, the above substituents of substituent group (ii) may 15 also each independently be substituted further by at least one substituent selected identically or differently from the group consisting of: (iii) "alkyl"; the Z2 radical is independently hydrogen; 20 the Z3 radical is independently selected from the group consisting of: (a) "aryl"; where, optionally, the above substituents of substituent group (a) may each independently be substituted by at least one substituent selected identically or differently from the group consisting of: 25 (i) "-O-alkyl, OH"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen. W02007/054556 PCT/EP2006/068322 -465

11. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (1) according to one of Claims 1, 10, where, in (E), the Z1 radical is independently selected from the group consisting of "3-methoxy-1 ylurea, 3-(prop-1-yn-3-yl)-1-ylurea, 3-[4-(tert-butydimethylsilanyloxy)butyl)-1-ylurea, 5 4-(N-ethyl carbamate)butyl-1-ylurea, 4-(methyl carbonate)-butyl-1-ylurea, 4-(2,3 dihydroxypropyl carbonate)butyl-1-ylurea, 4-(2,2-dimethyl-[1 , 3]dioxolan-4-ylmethyl carbonate)butyl-1-ylurea, 4-(diethyl phosphate)butyl-1-ylurea, 4-(butyl phosphate) 1-ylurea, N-oxalic monoamide ethyl ester, N-ethyl-N'-oxalamide, 2-(diethyl phosphate)ethyl-1-ylurea, 2-(ethyl phosphate)-1 -ylurea, 3-(2-diethylamino 10 ethoxy)propyl-1-ylurea, 4-[(2,2 dimethylpropionyloxymethoxy)phosphinoyloxymethyl 2,2-dimethylpropanoate]butyl 1-ylurea, 4-[1-(1-acetoxyethoxy)ethoxyphosphinoyloxy acetate]butyl-1-ylurea"; the Z2 radical is independently hydrogen; the Z3 radical is independently selected from the group consisting of "phenyl, 4 15 hydroxy-3-methoxyphenyl"; the Z4 radical is independently hydrogen; the Z5 radical is independently hydrogen.

12. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (II) 20 R2 N R4 R1 N N R3 (I in which the substituents R1-R4 are each defined as follows: 25 R1 and R2 may each independently be hydrogen or NR5R6, with the prerequisite that when R1 = NR5R6, R2 = H, and when R2 = NR5R6, R1 = H, where R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, 30 alkylaryl or alkylheteroaryl substituents may themselves in turn be mono- or W02007/054556 -466- PCT/EP2006/068322 polysubstituted, identically or differently, by F, Cl, Br, 1, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 ,CHO, C(O)OH, C(O)OR12, C(O)NH 2 , C(O)NHR12, C(O)NR12R13, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , 5 P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, p may assume the value of 0, 1, 2, 3, 4 or 5 and the R12 and R13 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R12 and R13 together may form a heterocyclyl ring 10 and R6: may be -C(Y)NR7R8 where Y may independently be 0 or S and R7 and R8 may each independently be 15 hydrogen, unsubstituted or substituted alkyl, where the alkyl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylcycloalkyl, NH 20 alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O)-alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 alkylheteroaryl, NO 2 , SH, S-alkyl, S-cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, 25 OH, OCF 3 , O(-alkylO)p-alkyl, 0-cycloalkyl, 0-heterocyclyl, 0-aryl, 0-heteroaryl, 0 alkylcycloalkyl, 0-alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O) alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OS0 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 -alkylheteroaryl, 30 OP(O)(OH) 2 , C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, C02 cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C02 alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH- W02007/054556 PCT/EP2006/068322 -467 alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO-alkyl, SO-aryl, S0 2 -alkyl, S0 2 -aryl, SO 2 NH 2 , SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH heteroaryl, SO 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 5 2, 3,4 or5, unsubstituted or substituted cycloalkyl, where the cycloalkyl radical may be mono or polysubstituted, identically or differently, by F, Cl, Br, I, NH 2 , NH-alkyl, NH cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylaryl, NH 10 alkylheteroaryl, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O)-alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, OH, O(-alkylO)p-alkyl, 0 cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, 0-alkylaryl, 0-alkylheteroaryl, 15 OC(O)-alkyl, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OSO 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS02 alkylheteroaryl, OP(O)(OH)2, CO 2 H, C0 2 -alkyl, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, 20 C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , alkyl, or aryl, where p may assume the value of 0, 1, 2, 3, 4 or 5, 25 unsubstituted or substituted heterocyclyl, where the heterocyclyl radical may be mono- or polysubstituted, identically or differently, by OH, 0-alkyl, 0-aryl, NH 2 , NH alkyl, NH-aryl, alkyl, alkylaryl or aryl, 30 unsubstituted or substituted aryl, where the aryl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, l, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, 35 NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O)- W02007/054556 PCT/EP2006/068322 -468 alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, 0-cycloalkyl, 0-heterocyclyl, 0-aryl, 0-heteroaryl, 0-alkylcycloalkyl, 0 5 alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, O-alkylOH, O-(CH 2 )n-0, OC(O) alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O) heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OS0 2 -alkyl, OS0 2 cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OSO 2 -alkylaryl, OS0 2 alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, CO 2 H, CO2 10 alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C02 alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , 15 C(O)N(aryl) 2 , C(O)N(heteroaryl)2, SO-alkyl, SO-aryl, S0 2 -alkyl, S0 2 -aryl, SO 2 NH 2 , SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO3H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and n the value of 1, 2 or 3, 20 unsubstituted or substituted heteroaryl, where the heteroaryl radical may be mono or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, 25 NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, 0-cycloalkyl, 0 heterocyclyl, O-aryl, 0-heteroaryl, 0-alkylcycloalkyl, 0-alkylheterocyclyl, 0 30 alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O) heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OSO 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 -heterocyclyl, OS02-aryl, OS02 heteroaryl, OS0 2 -alkylaryl, OS0 2 -alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O) aryl, C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, 35 C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, W02007/054556 PCT/EP2006/068322 - 469 C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO 2 NH 2 , 5 SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, SO 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5, -C(O)-R39 where R39 may be alkyl, aryl or heteroaryl, and the alkyl, aryl and 10 heteroaryl substituents may themselves in turn be substituted, or R7 and R8 together may form a heterocyclyl ring, R3 and R4 may each independently be: 15 hydrogen, where R3 and R4 are not simultaneously hydrogen, substituted alkyl, where the alkyl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , 20 SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)OH, C(O)OR14, C(O)NH 2 , C(O)NHR14, C(O)NR14R15, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R14 and R15 radicals may each independently be alkyl, 25 cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R14 and R15 together may form a heterocyclyl ring, substituted aryl, where the aryl radical is mono- or polysubstituted, identically or differently, by substituents selected from the group of NH-alkyl, NH-cycloalkyl, NH 30 heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylcycloalkyl, NH-alkylheterocyclyl, NH alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , N(aryl) 2 , NHC(O)-alkyl, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, S-alkyl, S-aryl, S 35 heteroaryl, O-alkyl, 0-cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, 0- W02007/054556 PCT/EP2006/068322 - 470 alkylcycloalkyl, 0-alkyiheterocyclyl, 0-alkylaryl, 0-alkyiheteroaryl, 00(O)-alkyl, 00(O)-cycloalkyl, 00(O)-heterocyclyl, OC(O)-aryl, 00(O)-heteroaryl, 00(0) alkylaryl, 00(0)-alkylheteroaryl, 0S0 2 -alkyl, 0S0 2 -cycloalkyl, 0S0 2 -heterocyclyl, 0S0 2 -aryl, 0S0 2 -heteroaryl, 0S0 2 -alkylaryl, 0S0 2 -alkylheteroaryl, C(0)-alkyl, 5 C(O)-aryl, 0(0)-heteroaryl, C0 2 -alkyl, 00 2 -CYCloalkyl, 00 2 -heterocyclyl, 00 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyi, C0 2 -alkylaryl, C0 2 alkyiheteroaryl, C(O)NH-alkyl, C(O)NH-cycloalkyl, C(0)NH-heterocyclyl, C(0)NH aryl, C(O)NH-heteroaryl, C(0)NH-alkylcycloalkyl, C(0)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(0)NH-alkylheteroaryl, C(0)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , 10 C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO-alkyl, SO-ary!, S0 2 -alkyl, S0 2 -aryl, SO 2 NH alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, S0 2 O-alkyl, S0 2 0-aryl, W02007/054556 PCT/EP20061068322 S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents are themselves in turn substituted by 0(-alkylO), alkyl, OP(O)(Oalkyl) 2 , OP(0)(Oaryl) 2 , C(O)OR16, C(O)NH 2 , C(0)NHR16, 5 C(O)NR16R17, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 1, 2, 3, 4 or 5, and the R16 and R17 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R16 and R17 together may form a heterocyclyl ring, 10 with the prerequisite that when R3 or R4 is alkylheterocyclyl-substituted aryl, R4 or R3 is correspondingly aaryl, and where the aryl radical is mono- or polysubstituted, identically or differently, by substituents selected from the group of NR20-alkyl, NH-R38, NHC(O)-R38, 15 NR19C(O)-alkyl, NR19C(O)-cycloalkyl, NR19C(O)-heterocycly, NR19C(O)-aryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O)-alkylheterocyclyl, NR19C(O)-alkylaryl, NR19C(O)-alkylheteroaryl, NR18C(0)O-R19, NR18C(O)NR18R18, O-R38, OC(O)-R38, OC(O)-alkylcycloalkyl, OC(0) alkylheterocyclyl, 0C(O)O-R19, OC(O)NR18R18, OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , 20 C(O)O-R38, C(O)NH-R38, C(O)NR20-alkyl, C(O)NR19-alkylR21, C(O)NR180-R18, C(O)NR18NR18R18 and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents may themselves in turn be substituted by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , 0(-alkylO)p-alkyl, O-aryl, OSO 3 H, 25 OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , CHO, C(O)OH, C(O)OR22, C(O)NH 2 , C(O)NHR22, C(O)NR22R23, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R22 and R23 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, 30 alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R22 and R23 together may form a heterocyclyl ring, substituted heteroaryl, where the heteroaryl radical is mono- or polysubstituted, identically or differently, by substituents selected from the group of NH-alkyl, NH 35 cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH-alkylcycloalkyl, NH- W02007/054556 PCT/EP2006/068322 -472 alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , N(aryl) 2 , NHC(O)-alkyl, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O)-alkylheteroaryl, NHSO 2 -alkyl, NHS0 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 5 alkylheteroaryl, S-alkyl, S-aryl, S-heteroaryl, 0-alkyl, 0-cycloalkyl, O-aryl, 0 heteroaryl, O-alkylcycloalkyl, 0-alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-cycloalkyl, OC(0)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OS0 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 -alkylheteroaryl, 10 C(O)-alkyl, C(0)-aryl, C(O)-heteroaryl, C0 2 -alkyl, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)NH-alkyl, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , 15 C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , S0 2 NH-alkyl, SO 2 NH-aryl, S0 2 NH-heteroaryl, SO 2 NH-alkylaryl, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents are themselves in turn substituted by 0(-alkylO)p-alkyl, OP(O)(Oalkyl) 2 , 20 OP(O)(Oary) 2 , C(O)OR16, C(0)NH 2 , C(O)NHR16, C(O)NR16RI7, SO 2 alkyl, S0 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(0)(Oaryl) 2 , cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 1, 2, 3, 4 or 5 and the R1 6 and R17 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R16 and 25 R17 together may form a heterocyclyl ring, and where the heteroaryl radical is mono- or polysubstituted, identically or differently, by substituents selected from the group of NR20-alkyl, NH-R38, NHC(O)-R38, NR19C(O)-alkyl, NR19C(O)-cycloalkyl, NR19C(O)-heterocyclyl, 30 NR19C(O)-aryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O) alkylheterocyclyl, NR19C(O)-alkylaryl, NR19C(O)-alkylheteroaryl, NR18C(0)0 R19, NR18C(O)NR18R18, NHSO 2 -alkylheterocyclyl, 0-R38, 0-heterocyclyl, OC(0)-R38, OC(O)-alkylcycloalkyl, OC(0)-alkylheterocyclyl, OC(0)O-R19, OC(O)NR18R18, OP(O)(Oalkyl) 2 , OP(O)(Oaryl)2, C(O)O-R38, C(O)NH-R38, 35 C(O)NR20-alkyl, C(O)NR19-alkylR21, C(O)NR180-R18, C(O)NR18NR18R18, and W02007/054556 PCT/EP2006/068322 -473 the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents may themselves in turn be substituted by F, Cl, Br, 1, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , 5 CHO, C(O)OH, C(O)OR22, C(O)NH 2 , C(O)NHR22, C(O)NR22R23, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl or alkylaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R22 and R23 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl 10 or alkylheteroaryl, or R22 and R23 together may form a heterocyclyl ring, NR24R25 where R24 may be -C(O)-R26, -S0 2 R26, -C(O)OR26 or -C(O) NR27R28 and where R25 may be hydrogen, alkyl, cycloalkyl, aryl or heteroaryl and where R26 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, 15 alkylheterocyclyl, alkylaryl, alkylheteroaryl, and R27 and R28 may each independently be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, or R27 and R28 together may form a heterocyclyl ring and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents 20 may themselves in turn be substituted, and R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, 25 and R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, 30 and R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, and R38 may be alkyl, where the alkyl radical may be saturated or unsaturated, straight-chain or branched, having from 9 to 30 carbon atoms, and the C9-30 35 alkenyls have at least one C-C double bond and C 9 - 30 -alkynyls have at least one C- W02007/054556 PCT/EP2006/068322 - 474 C triple bond, where the alkenyls may be present either in (E)- or in (Z) conformation; and physiologically tolerated salts, derivatives or analogues of the compounds of 5 the formula 1, and their solvates, hydrates, polymorphic forms and prodrugs, the compounds of the general formula I and their salts, derivatives or analogues, their solvates, hydrates, polymorphic forms and prodrugs being present in the form of their racemates, in the form of the pure enantiomers and/or diastereomers or in the form of mixtures of these enantiomers and/or diastereomers or in the form of 10 the tautomers.

13. Novel pyrido[2,3-b]pyrazine derivatives of the general formula (11) according to Claim 12, in which the substituents R1-R4 are each defined as follows: R1 and R2 may each independently be hydrogen or NR5R6, with the prerequisite 15 that when R1 = NR5R6, R2 = H, and when R2 = NR5R6, R1 = H, where R5 may be hydrogen, alkyl, R38, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be mono- or 20 polysubstituted, identically or differently, by F, Cl, Br, I, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , NO 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, O-aryl, OSO 3 H, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , CHO, C(O)OH, C(O)NH 2 , C(O)OR12, C(O)NHR12, C(O)NR12R13, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, p may assume the 25 value of 0, 1, 2, 3, 4 or 5 and the R1 2 and R1 3 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, or R12 and R13 together may form a heterocyclyl ring and R6: 30 may be -C(O)NR9-Y-R1O where Y may independently be 0 or NR1 1 W02007/054556 PCT/EP2006/068322 - 475 and R9 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves be substituted, 5 and R10 and R1 1 may each independently be hydrogen, 10 unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, where the heterocyclyl radical may be 15 mono- or polysubstituted, identically or differently, by OH, 0-alkyl, 0-aryl, NH 2 , NH alkyl, NH-aryl, alkyl, alkylaryl or aryl, unsubstituted or substituted aryl, where the aryl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, 20 NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, 25 NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S cycloalkyl, S-heterocyclyl, S-aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, O-cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, 0-alkylcycloalkyl, 0 alkylheterocyclyl, 0-alkylaryl, 0-alkylheteroaryl, O-alkylOH, O-(CH 2 )n-O, OC(O) alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O) 30 heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OSO 3 H, OS0 2 -alkyl, OS0 2 cycloalkyl, OS0 2 -heterocyclyl, OSO 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, C0 2 H, C02 alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C02 alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , 35 C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH- W02007/054556 PCT/EP2006/068322 -476 aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO-alkyl, SO-aryl, S0 2 -alkyl, S0 2 -aryl, SO 2 NH 2 , SO 2 NH.-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO3H, S0 2 0-alkyl, 5 S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and n the value of 1, 2 or 3, unsubstituted or substituted heteroaryl, where the heteroaryl radical may be mono or polysubstituted, identically or differently, by F, CI, Br, 1, CF 3 , CN, NH 2 , NH-alkyl, 10 NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, NH alkylNH 2 , NH-alkylOH, N(alkyl) 2 , NHC(O)-alkyl, NHC(O)-R38, NHC(O)-cycloalkyl, NHC(O)-heterocyclyl, NHC(O)-aryl, NHC(O)-heteroaryl, NHC(O)-alkylaryl, NHC(O) alkylheteroaryl, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 -heterocyclyl, NHSO 2 -aryl, 15 NHSO 2 -heteroaryl, NHSO 2 -alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S aryl, S-heteroaryl, OH, OCF 3 , O(-alkylO)p-alkyl, O-R38, 0-cycloalkyl, 0 heterocyclyl, 0-aryl, 0-heteroaryl, 0-alkylcycloalkyl, 0-alkylheterocyclyl, 0 alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O) heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylaryl, OC(O)-alkylheteroaryl, 20 OSO 3 H, OS0 2 -alkyl, OS0 2 -cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 heteroaryl, OS0 2 -alkylaryl, OS0 2 -alkylheteroaryl, OP(O)(OH) 2 , C(O)-alkyl, C(O) aryl, C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, 25 C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl) 2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , SO 2 NH 2 , SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, where p 30 may assume the value of 0, 1, 2, 3, 4 or 5, or R10 and R1 1 together may form a heterocyclyl ring, R3 and R4 may each independently be: 35 W02007/054556 PCT/EP2006/068322 - 477 hydrogen hydroxyl 5 halogen such as fluorine, chlorine, bromine, iodine unsubstituted or substituted alkyl, where the alkyl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, 1, CN, CF 3 , NH 2 , NH-alkyl, NH-aryl, N(alkyl) 2 , SH, S-alkyl, OH, OCF 3 , O(-alkylO)p-alkyl, 0-aryl, OSO 3 H, 10 OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl) 2 , C(O)OH, C(O)OR14, C(O)NH 2 , C(O)NHR14, C(O)NR14R15, SO 3 H, SO 2 alkyl, SO 2 aryl, P(O)(OH) 2 , P(O)(Oalkyl) 2 , P(O)(Oaryl) 2 , cycloalkyl, heterocyclyl, aryl or heteroaryl, where p may assume the value of 0, 1, 2, 3, 4 or 5 and the R14 and R1 5 radicals may each independently be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, 15 alkylaryl or alkylheteroaryl, or R14 and R15 together may form a heterocyclyl ring, unsubstituted or substituted aryl, where the aryl radical may be mono- or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH 20 alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , N(aryl) 2 , NR20-alkyl, NHC(O)-alkyl, NHC(O)-R38, NR19(O)-alkyl, NHC(O) cycloalkyl, NR19C(O)-cycloalkyl, NHC(O)-heterocyclyl, NR19C(O)-heterocyclyl, NHC(O)-aryl, NR19C(O)-aryl, NHC(O)-heteroaryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O)-alkylheterocyclyl, NHC(O)-alkylaryl, 25 NR19C(O)-alkylaryl, NHC(O)-alkylheteroaryl, NR19C(O)-alkylheteroaryl, NR18C(O)O-Ri9, N R18C(O)NR18R18, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHSO 2 -alkylheterocyclyl, NHSO 2 alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S-aryl, S-heteroaryl, OH, OCF 3 , 0-alkyl, O-R38, 0-cycloalkyl, 0-heterocyclyl, O-aryl, 0-heteroaryl, 0 30 alkylcycloalkyl, 0-alkylheterocyclyl, O-alkylaryl, 0-alkylheteroaryl, O-(CH 2 )n-O, OC(O)-alkyl, OC(O)-R38, OC(O)-cycloalkyl, OC(O)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, OC(O)-alkylcycloalkyl, OC(O)-alkylheterocyclyl OC(O)-alkylaryl, OC(O)-alkylheteroaryl, OC(0)O-R19, OC(O)NR18R18, OSO 3 H, OS0 2 -alkyl, OS02 cycloalkyl, OS0 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OS0 2 35 alkylheteroaryl, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl)2, C(O)-alkyl, C(O)-aryl, W02007/054556 -478- PCT/EP2006/068322 C(O)-heteroaryl, CO 2 H, C0 2 -alkyl, C0 2 -R38, CO 2 -cycloalkyl, C0 2 -heterocyclyl, C0 2 -aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, 5 C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl)2 , C(O)N(aryl) 2 , C(O)N(heteroaryl)2, C(0)NR20 alkyl, C(O)NR19-alkylR21, -C(O)NR180-R18, -C(O)NR18NR18R18, SO-alkyl, SO aryl, S0 2 -alkyl, S0 2 -aryl, SO 2 NH 2 , SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO 3 H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, 10 alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, n may assume the value of 1, 2 or 3, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and alkylheteroaryl substituents may themselves in turn be substituted, 15 unsubstituted or substituted heteroaryl, where the heteroaryl radical may be mono or polysubstituted, identically or differently, by F, Cl, Br, I, CF 3 , CN, NH 2 , NH-alkyl, NH-R38, NH-cycloalkyl, NH-heterocyclyl, NH-aryl, NH-heteroaryl, NH alkylcycloalkyl, NH-alkylheterocyclyl, NH-alkylaryl, NH-alkylheteroaryl, N(alkyl) 2 , N(aryl) 2 , NR20-alkyl, NHC(O)-alkyl, NHC(O)-R38, NR19C(O)-alkyl, NHC(O) 20 cycloalkyl, NR19C(O)-cycloalkyl, NHC(O)-heterocyclyl, NR19C(O)-heterocyclyl, NHC(O)-aryl, NR19C(O)-aryl, NHC(O)-heteroaryl, NR19C(O)-heteroaryl, NR18C(O)-alkylcycloalkyl, NR18C(O)-alkylheterocyclyl, NHC(0)-alkylaryl, NR19C(O)-alkylaryl, NHC(O)-alkylheteroaryl, NR19C(O)-alkylheteroaryl, NR18C(O)O-R19, NR18C(O)NR18R18, NHSO 2 -alkyl, NHSO 2 -cycloalkyl, NHSO 2 25 heterocyclyl, NHSO 2 -aryl, NHSO 2 -heteroaryl, NHS02-alkylheterocyclyl, NHSO 2 alkylaryl, NHSO 2 -alkylheteroaryl, NO 2 , SH, S-alkyl, S-aryl, S-heteroaryl, OH, OCF 3 , 0-alkyl, O-R38, 0-cycloalkyl, 0-heterocyclyl, 0-aryl, 0-heteroaryl, 0 alkylcycloalkyl, 0-alkylheterocyclyl, O-alkylaryl, 0-alkylheteroaryl, OC(O)-alkyl, OC(0)-R38, OC(O)-cycloalky, OC(0)-heterocyclyl, OC(O)-aryl, OC(O)-heteroaryl, 30 OC(O)-alkylcycloalkyl, OC(O)-alkylheterocyclyl OC(0)-alkylaryl, OC(O) alkylheteroaryl, OC(O)O-R19, OC(O)NR18R18, OSO 3 H, OSO 2 -alkyl, OSO2 cycloalkyl, OSO 2 -heterocyclyl, OS0 2 -aryl, OS0 2 -heteroaryl, OS0 2 -alkylaryl, OSO 2 alkylheteroaryl, OP(O)(OH) 2 , OP(O)(Oalkyl) 2 , OP(O)(Oaryl)2, C(O)-alkyl, C(O)-aryl, C(O)-heteroaryl, C0 2 H, C0 2 -alkyl, C0 2 -R38, C0 2 -cycloalkyl, C0 2 -heterocyclyl, 35 C02-aryl, C0 2 -heteroaryl, C0 2 -alkylcycloalkyl, C0 2 -alkylheterocyclyl, C0 2 -alkylaryl, W02007/054556 PCT/EP2006/068322 - 479 C0 2 -alkylheteroaryl, C(O)-NH 2 , C(O)NH-alkyl, C(O)NH-R38, C(O)NH-cycloalkyl, C(O)NH-heterocyclyl, C(O)NH-aryl, C(O)NH-heteroaryl, C(O)NH-alkylcycloalkyl, C(O)NH-alkylheterocyclyl, C(O)NH-alkylaryl, C(O)NH-alkylheteroaryl, C(O)N(alkyl) 2 , C(O)N(cycloalkyl)2 , C(O)N(aryl) 2 , C(O)N(heteroaryl) 2 , C(O)NR20 5 alkyl, C(O)NR19-alkylR21, -C(O)NR180-R18, -C(O)NR18NR18R18, SO 2 NH 2 , SO 2 NH-alkyl, SO 2 NH-aryl, SO 2 NH-heteroaryl, SO 2 NH-alkylaryl, SO3H, S0 2 0-alkyl, S0 2 0-aryl, S0 2 0-alkylaryl, alkyl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl and 10 alkylheteroaryl substituents may themselves in turn be substituted, OR29 where R29 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl 15 or alkylheteroaryl substituents may themselves in turn be substituted, SR30 where R30 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkyiheterocyclyl, alkylaryl or alkylheteroaryl, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, 20 alkylaryl or alkylheteroaryl substituents may themselves in turn be substituted, NR31R32 where R31 and R32 may each independently be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, -C(O)-R33, -S0 2 R33, -C(O)OR33 and -C(O)-NR34R35, where 25 R33 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, and R34 and R35 may each independently be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl, alkylheteroaryl, or R34 and R35 together may form a heterocyclyl ring, 30 or R31 and R32 together may form a heterocyclyl ring, and the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl substituents may themselves in turn be substituted, W02007/054556 -480- PCT/EP2006/068322 and R18 may be hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, and R19 may be alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, 5 alkylheterocyclyl, alkylaryl or alkylheteroaryl, and R20 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, alkylcycloalkyl, alkylheterocyclyl, alkylaryl or alkylheteroaryl, 10 and R21 may be cycloalkyl, heterocyclyl, aryl, heteroaryl, and R38 may be alkyl, where the alkyl radical may be saturated or unsaturated, straight-chain or branched, having from 9 to 30 carbon atoms, and the C9-30 alkenyls have at least one C-C double bond and C 9 - 3 0 -alkynyls have at least one C 15 C triple bond, where the alkenyls may be present either in (E)- or in (Z) conformation; and physiologically tolerated salts, derivatives or analogues of the compounds of the formula I, and their solvates, hydrates, polymorphic forms and prodrugs, 20 the compounds of the general formula I and their salts, derivatives or analogues, their solvates, hydrates, polymorphic forms and prodrugs being present in the form of their racemates, in the form of the pure enantiomers and/or diastereomers or in the form of mixtures of these enantiomers and/or diastereomers or in the form of the tautomers. 25

14. Pyrido[2,3-b]pyrazine derivatives of the general formula (ll) according to one of Claims 12,13, where R2 = H.

15. Pyrido[2,3-b]pyrazine derivatives of the general formula (II) according to one of 30 Claims 12, 13, where R2 and R4 = H. W02007/054556 PCT/EP2006/068322 - 481 16. Pyrido[2,3-b]pyrazine derivatives of the general formula (II) according to Claim 12, where R2 and R4 = H and R6 = -C(Y)NR7R8, where Y may independently be 0 or S and R7 and R8 are each as defined in Claim 12. 5 17. Pyrido[2,3-b]pyrazine derivatives of the general formula (II) according to one of Claims 12, 13, characterized in that the alkyl radical may be methyl, ethyl, n-propyl, 2-propyl, n-butyl, sec-butyl, tert.-butyl, n-pentyl, iso-pentyl, neo-pentyl, n-hexyl, 2 hexyl, n-octyl, ethylenyl (vinyl), ethynyl, propenyl (-CH 2 CH=CH 2 ; -CH=CH-CH 3 , C(=CH 2 )-CH 3 ), propynyl (-CH 2 -C=CH, -C=C-CH 3 ), butenyl, butynyl, pentenyl, 10 pentynyl, hexenyl, hexynyl, heptenyl, heptynyl, octenyl and octynyl.

18. Pyrido[2,3-b]pyrazine derivatives of the general formula (11) according to one of Claims 12, 13, characterized in that the heterocyclyl radical may be tetrahydrofuryl, pyrrolidinyl, imidazolidinyl, thiazolidinyl, tetrahydropyranyl, piperidinyl, piperazinyl 15 and morpholinyl.

19. Pyrido[2,3-b]pyrazine derivatives of the general formula (1l) according to one of Claims 12, 13, characterized in that the heteroaryl radical may be pyrrolyl, furyl, thienyl, thiazolyl, oxazolyl, oxadiazolyl, isoxazolyl, pyrazolyl, imidazolyl, triazole, 20 tetrazole, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazine, phthalazinyl, indolyl, indazolyl, indolizinyl, quinolinyl, isoquinolinyl, quinoxalinyl, quinazolinyl, pteridinyl, carbazolyl, phenazinyl, phenoxazinyl, phenothiazinyl, acridinyl.

20. Pyrido[2,3-b]pyrazine derivatives of the general formulae (1), (11) according to one 25 of Claims 1 to 19, selected from the group consisting of: W02007/054556 -8-PCT1EP2006/068322 Compound 1 1 -ethyI-3-(3phenyethyflypyrido2,3b~pyrazifl 6 -yl)urea -'_N N Q 'N " H H Compound 2 1 -ehl--3t he--lehyylyid 23b yain6y)ur N H H N N 5 Compound 3 1 -(3-cyc o pro pyl eth yn yIpyrid o[2, 3-bl pyrazi n-6-yl)-3-ethy u re a H H Compound 4 1 -[3-(3-dimethylamiloprop-1 -ynyI)pyrido[2,3-b~pyrazifl- 6 -yI1- 3 ethylurea N "_ N N Nl 'N, H H N 10 Compound 5 1 -[3-((E)-2-cyclohexylviflyl )pyrido[2, 3-b~pyrazin-6-yII-3-ethylu rea N '__ N N N N) " H H W02007/054556 -483- PCT/EP2006/068322 Compound 6 1-ethyl-3-[3-((E)-3-methoxypropenyl)pyrido[2,3-b]pyrazin-6-yl]urea Nl NN "---N I ~N I N~ H H Compound 7 N 0 , NI N N ( N 5 Compound 8 N 0, NI N N N Compound 9 4-[6-(3-ethylurea)pyrido[2, 3-b]pyrazin-3-yl]phenyl methyl carbonate N "- N N N Nl H H K::: 0 Compound 10 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl 2-methoxyethyl 10 carbonate N N N H H0 -- O, Compound 11 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl phenyl carbonate oN No H H Compound 12 4-[6-(3-ethylurea)pyrido[2,3-bpyrazil-3-ylphenyI diethyicarbamnate W02007/054556 PCT/EP2006/068322 - 484 yN N N N H H O Compound 13 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyI (E)-3 N N N N 'N H H phen 5 Compound 14 4-[6-(3-ethylurea)pyrido[2,3-bpyrazin-3-yl]phenyl nonadecanoate N 0 C 1 H 37 Compound 15 1-(3-benzylpyrido[2,3-b]pyrazin-6-yl)-3-ethylurea N N N H H Compound 16 3-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyI 2-methoxyethyl 10 carbonate 'N N -- iN N H H I i 7 0 Compound 1 7 4-[6-(3-ethylurea)pyrido[2, 3-b]pyrazin-3-yIlphenyI isobutyl carbonate N '---N N N N' I : H H 07 " W02007/054556 PCT/EP2006/068322 - 485 Compound 18 but-2-ynyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]pheny carbonate H H Compound 19 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl dimethylcarbamate N N N N N Q H H K0 1N 5 Compound 20 4-[6-(3-ethyl-1 -phenylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl ethylcarbamate N N N IN N H H N-^O H Compound 22 2-methoxyetyl4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl~phenyl} 10 carbamate -N N N H H N N O O H Compound 21 1-ethtyl-{-[4-(3-ethylurea)phlpyrido[2,3-b]pyrazin-6yn-yl}uea 10 carbamate N '- N N N H H ~ N 0-- , H 15 Compound 22 2-meeth thyl 3-4-6(3-ethylurea )enlpyrido[2, 3-b]pyrazin--y~phey} W02007/054556 PCT/EP2006/068322 - 486 N N N N H H N N H H Compound 24 1 -{3-[4-(3,3-dimethylurea)phenyl]pyrido[2,3-bpyrazin-6-yl}-3 ethylurea N H HI - ' N N NN " ! N H 5 Compound 25 1 -ethyl-3-{3-[6-(3-ethylurea)pyridin-3-yl]pyrido[2,3-b]pyrazin-6 yl}urea ,I N N N N H H Compound 26 1 -ethyl-3-{3-[2-(4-fluorophenyl)ethyl]pyrido[2,3-b]pyrazin-6-ylurea N H HF F 10 Compound 27 1 -ethyl-3-{3-[(E)-2-(4-fluorophenyl)vinyl] pyrido[2,3-b]pyrazin-6-yl} urea '__ N N QN NN H H F Compound 28 1 -ethyl-3-[3-(4-morpholin-4-ylmethylphenyl)pyrido[2,3-bpyrazin-6 yl]urea W02007/054556 PCT/EP2006/068322 - 487 N N N N H H (N 0 Compound 29 1-ethyl-3-(3-{4-[2-(2-methoxyethoxy)ethoxy]phenyl}pyrido[2,3 b]pyrazin-6-yl)urea N >N"Qa "-NN N N H H O 5 Compound 30 N-{4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl}-2-( 2 methoxyethoxy)acetamide N N H H H Compound 31 N-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]-4-methylbenzamide "N'N N N N H H H K 10 Compound 32 4-[6-(3-ethylurea)pyrido [2,3-b]pyrazin-3-yl]-2-methoxyphenyl 2 methoxyethyl carbonate N N -Z N N N Q H HO Compound 33 2-benzyloxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyI carbonate W02007/054556 PCT/EP2006/068322 - 488 N '- I N N H H Compound 34 2-benzyloxyethyl 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]- 2 methoxyphenyl carbonate N H H N N 5 Compound 35 2-benzyloxy-N-{4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]phenyl} acetamide NN H H H Compound 36 1-[4-(tert-butyldimethylsilanyloxy)butyl)-3-(3-phenylpyrido[ 2 ,3-b] 10 pyrazin-6-yl)urea Compound 37 1-[4-(tert-butyldimethylsilanyloxy)butyl]-3-[3-( 4 -hydroxy-3 methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea N 15 Compound 38 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl ethylcarbamate N O O% N'N(XN N yH H 0 W02007/054556 -489- PCT/EP2006/068322 Compound 39 methyl 4-[3-(3-phenylpyrido[2,3-blpyrazin-6-yl)urea]butyI carbonate N H H 0 Compound 40 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl 4-[3-(3-phenylpyrido[2,3 b]pyrazin-6-yl)urea]butyl carbonate 0 5 Compound 41 2,3-dihydroxypropyl 4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)u rea) butyl carbonate N HO o o HO0 N~~-N N N N. Compound 42 diethyl {4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl} 10 phosphate N 0- NN N N O H Compound 43 {4-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]butyl}phosphoric acid HO/ Y- N N N N HO H H Compound 44 diethyl (4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3-b]pyrazin-6 15 yl]urea}butyl)phosphate N O " NN ' N N N. 0 SH HOH W02007/054556 PCT/EP2006/068322 -490 Compound 45 (4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3-b]pyrazin-6 yl]urea}butyl)phosphoric acid ON N N HO H H OH Compound 46 1 -ethyl-3-[3-(3-trimethylsilanylphenyl)pyrido[2,3-b]pyrazin-6-yl]urea N si H H N N 5 Compound 47 1-[ 3 -( 4 -cyclohexylphenylamino)pyrido[23-b]pyrazin-6-yl]-3-ethylurea N N N N N H H H Compound 48 1 -ethyl-3-[3-(4-methanesulphonylphenyamino)pyrido[2,3-b]-pyrazin 10 6-yl]urea 0 N N N N H H H Compound 49 N-{5-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]-2-methyl phenyl}methanesulphonamide N 0\O N N N N N H H H H 15 Compound 50 3-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]-N-methyl benzamide N e-N'N N N> N I K H H H 0 W02007/054556 PCT/EP2006/068322 - 491 Compound 51 1 -ethyl-3-[3-(4-piperidin-1-ylmethylphenylamino)pyrido[ 2 , 3 -b] pyrazin-6-yl]urea N N H N H H H Compound 52 1 -ethyl-3-[3-(4-thiophen-3-ylphenylamino)pyrido[2,3-b]pyrazin-6 5 yl]urea N S N N N N H H H Compound 53 N-{4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylamino]phenyl} acetamide H N N NNN N N N N N H H H 10 Compound 54 ethyl 3 -[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-ylaminobenzoate N N N N N N H H Hx H) O 0 Compound 55 4-[6-(3-ethylurea)pyrido[2[3-blpyrazin-3-y]phenYl 2-methoxyethyl carbonate hydrochloride N " I N N N: N H HC 0 15 Compound 56 2-methoxyethyl 4-[6-(3-ethylurea)pyrido[2,3-bIpyrazin3-yl]phenyI carbonate p-toluenesulphonate W02007/054556 PCT/EP2006/068322 - 492 NN N N H H 1 O O x HO-S 0 Compound 57 4-{6-[3-(4-hydroxybutyl)urea]pyrido[2,3-b]pyrazin-3-ylphenyl 2 methoxyethyl carbonate N 5 Compound 58 4-{6-[3-(4-hydroxybutyl)urea]pyrido[2,3-b]pyrazin-3-yl}pheny 2 methoxyethyl carbonate hydrochloride HH x HCI Compound 59 N-(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxalic monoamide ethyl ester N N N H 0 10 Compound 60 N-ethyl-N'-(3-phenylpyrido[2,3-b]pyrazin-6-yl)oxalamide N N os JN N N O . H o Compound 61 NN H H OH Compound 62 diethyl {2-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urea]ethyl} 15 phosphate W02007/054556 -493- PCT/EP2006/068322 o N 0 0 i N o-I N N N N ro H H Compound 63 {2-[3-(3-phenylpyrido[2,3-b]pyrazin-6-yl)urealethyl}phosphoric acid N I N N N N OH H H Compound 64 1-[3-(2-diethylaminoethoxy)propyl]-3-[3-(4-hydroxy-3-methoxy 5 phenyl)pyrido[2,3-b]pyrazin-6-yllurea N. o-* N N N' H H OH Compound 65 (2,2-dimethylpropionyloxym ethoxy)-(4-{3-[ 3 -( 4 -hyd roxy-3-methoxy phenyl)pyrido[2,3-b]pyrazin-6-yl]urea)butyl)phosphinoyloxymethyI 2,2-dimethyl propanoate N. I ~~N N N N' o=H o o 10 Compound 66 1-[(1-acetoxyethoxy)-(4-{3-[3-( 4 -hydroxy-3-methoxyphenyl) pyrido[2,3-b]pyrazin-6-yl]urea}butyl)phosphinoyloxy]ethyl acetate NOH O 0 W02007/054556 PCT/EP2006/068322 - 494 Compound 67 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-y]2-methoxyphenyl diethylcarbamate N NN N N H H Compound 68 2-chloro-4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]-6-methoxy 5 phenyl diethylcarbamate N 'NN N N H H 0 N ci Compound 69 4-[6-(3-ethylurea)pyrido[2,3-b]pyrazin-3-yl]-2-methoxyphenyl 2-[2-(2 methoxyethoxy)ethoxy]ethyl carbonate N N N N H H O O O O o 10 Compound 70 1 -ethyl-3-{3-[4-(morpholine-4-sulfonyl)phenylamino]pyrido[2,3 b]pyrazin-6-yl}urea Compound 71 ethyl 5-[6-(3-ethylureido)pyrido[2,3-b]pyrazin-3-ylamino]-2-hydroxy benzoate HO 15 Compound 72 1 -[3-(3-diethylaminomethyl-4-hydroxyphenylamino)pyrido[ 2 ,3 b]pyrazin-6-yl]-3-ethylurea W02007/054556 -9-PCT/EP2006/068322 Compound 73 1 hl3[-6mrpoi--lyiin3yaioprdo23bprzn 6-yl]urea 5 Compound 74 1 -ethyl-3-{3-13-( 1 H-tetrazoI-5-yi)phelanfo]pyrido[2,3-b]pyrazifl 6 yI~urea If H - H- " 44 Compound 75 1 -ehl3[-3mrhln4ypenlmn~yio23bprzn6 yi] urea 10 Compound 76 1 -ethyl-3-[3-(4-imidazol-1 -ylphenylamino)pyrido[2,3-b] pyrazin-6 yI]urea . ... ... ... .. Compound 77 1 -ethyl-3-[3-(4-pyrrolid in-i -ylphenylamino)pyrido[2,3-b]pyrazifl- 6 15 yI]urea W02007/054556 PCT/EP2006/068322 - 496 Compound 78 1 -eth yi-3-{3-[4-(4-m ethyl pipe razifn- 1 -yI)phenylamino]pyrido[2,3 b]pyrazin-6-yI~urea 5 Compound 79 1 -ethyl-3-[3-(3-piperidin-1 -yimethylphenylamino)pyrido[2,3-b] pyrazin 6-yijurea N N N'~ H -H H Compound 80 1 -ethyl-3-[3-(4-morpholin-4-ylmethylPhelylamlo)pyrido[? ,3 b]pyrazin-6-yI]urea H III 10 Compound 81 1 -{3-[3-(2-cyciohexylethoxy)phenylaminojpyrido[2,3-b]pyrazin-6-yI} 3-ethylurea Compound 82 1 -ethyl-3-[3-(3-[1 ,2,4]triazol-1 -ylmethylphenylamino)pyrido[2. 3 15 b]pyrazin-6-yl]urea W02007/054556 PCT/EP2006/068322 -497 N, N . fl Compound 83 2,2-dimethyl[1,3]dioxolan-4-ylmethyl 4-{3-[3-(4-hydroxy-3 methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]ureido}butyl carbonate oo HO 5 Compound 84 2,3-dihydroxypropyl 4-{3-[3-(4-hydroxy-3-methoxyphenyl)pyrido[2,3 b]pyrazin-6-yl]ureido}butyl carbonate Compound 85 1-[3-(2-diethylaminoethoxy)propyl]-3-[3-(4-hydroxy- 3 methoxyphenyl)pyrido[2,3-b]pyrazin-6-yl]urea 10

21. Medicament comprising at least one pyrido[2,3-b]pyrazine derivative according to one of Claims 1 to 20. 15 22. Medicament according to Claim 21, comprising the pyrido[2,3-b]pyrazine derivative in combination with at least one further active pharmaceutical ingredient and/or pharmaceutically acceptable carriers and/or excipients. W02007/054556 -498- PCT/EP2006/068322

23. Process for producing a medicament according to one of Claims 21 to 22, characterized in that one or more pyrido[2,3-b]pyrazine derivatives according to one of Claims 1 to 20 are processed with pharmaceutically acceptable carriers and/or excipients to give pharmaceutical formulations, and brought into a 5 therapeutically usable form.

24. Compound according to one of Claims 1 to 20 for use as a pharmaceutical agent.

25. Use of a compound according to one of Claims 1 to 20 for producing a medicament 10 for modulating misdirected cellular signal transduction processes, especially for influencing the function of active and inactive receptor tyrosine kinases, and also cytoplasmic tyrosine, serine/threonine and lipid kinases, suc as c-Raf, B-Raf, Mek, MAPKs, PDGFRbeta, Flt-3, IGF1R, P13K, PKB/Aktl, c-Kit, c-Abl, FGFR1 and KDR. 15 26. Use of a compound according to one of Claims 1 to 20 for producing a medicament for the treatment or prophylaxis of physiological and/or pathophysiological states mediated by signal transduction pathways selected from the group consisting of: "ras-Raf-Mek-Erk signal transduction pathway, Pl3K-Akt signal transduction pathway and/or SAPK signal transduction pathway" in mammals. 20

27. Use of a compound according to one of Claims 1 to 20, 26, wherein the treatment or prophylaxis is brought about by modulation of the signal transduction pathway(s) selected from the group consisting of: "ras-Raf-Mek-Erk signal transduction pathway, Pl3K-Akt signal transduction pathway and/or SAPK signal transduction 25 pathway".

28. Use according to one of Claims 1 to 20, 26, wherein the physiological and/or pathophysiological states are mediated by enzymes selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". 30 W02007/054556 PCT/EP2006/068322 - 499 29. Use according to one of Claims 1 to 20, 26, 28, wherein the treatment or prophylaxis is brought about by modulation of one or more enzymes selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". 5 30. Use according to one of Claims 1 to 20, 26, 27, wherein the mediating and/or modulated signal transduction pathways are the ras-Raf-Mek-Erk signal transduction pathway and the PI3K-Akt signal transduction pathway.

31. Use according to one of Claims 1 to 20, 26, 27, wherein the mediating and/or 10 modulated signal transduction pathway is the Raf-Mek-Erk signal transduction pathway.

32. Use according to one of Claims 1 to 20, 26, 27, wherein the mediating and/or modulated signal transduction pathway is the PI3K-Akt signal transduction 15 pathway.

33. Use according to one of Claims 1 to 20, 26, 27, wherein the mediating and/or modulated signal transduction pathways are the SAPK signal transduction pathway and the PI3K-Akt signal transduction pathway. 20

34. Use according to one of Claims 1 to 20, 26, 27, wherein the mediating and/or modulated signal transduction pathway is the SAPK signal transduction pathway.

35. Use according to one of Claims 1 to 20, 26, 27, 30, 31, wherein the modulation of 25 the ras-Raf-Mek-Erk signal transduction pathway is brought about by modulation of one or more enzymes selected from the group consisting of: "tyrosine kinase, serine/threonine kinase, receptor-tyrosine kinase, cytoplasmic tyrosine kinase, cytoplasmic serine/threonine kinase". 30 36. Use according to Claim 35, wherein the enzyme is selected from the group consisting of: "Erk, Erk1, Erk2". W02007/054556 . PCT/EP2006/068322 -500

37. Use according to one of Claims 1 to 20, 26, 27, 30, 32, 33, wherein the modulation of the PI3K-Akt signal transduction pathway is brought about by modulation of one or more enzymes selected from the group consisting of: "Pl3K, Pl3Kalpha, Pl3Kbeta, Pl3Kgamma, Pl3Kdelta, P13K-C2alpha, P13K-C2beta, P13K-Vps34p". 5

38. Use according to one of Claims I to 20, 26, 27, 33, 34, wherein the modulation of the SAPK signal transduction pathway is brought about by modulation of one or more enzymes selected from the group consisting of: "tyrosine kinase, serine/threonine kinase, receptor-tyrosine kinase, cytoplasmic tyrosine kinase, 10 cytoplasmic serine/threonine kinase".

39. Use according to Claim 38, wherein the enzyme is selected from the group consisting of: "Jnk, Jnkl, Jnk2, Jnk3, p38, p38alpha, p38beta, p38gamma, p38delta". 15

40. Use according to one of Claims 1 to 20, 25 to 39, wherein two or more enzymes are modulated.

41. Use according to Claim 40, wherein at least one enzyme is selected from the group 20 consisting of: "Erk, Erk1, Erk2" and at least one enzyme is selected from the group consisting of: "P13K, P13Kalpha, Pl3Kbeta, Pl3Kgamma, P13Kdelta, PI3K-C2alpha, PI3K-C2beta, P13K-Vps34p".

42. Use according to Claim 40, wherein at least one enzyme is selected from the group 25 consisting of: "Jnk, Jnkl, Jnk2, Jnk3, p38, p38alpha, p38beta, p38gamma, p38delta" and at least one enzyme is selected from the group consisting of: "Pl3K, Pl3Kalpha, P13Kbeta, Pl3Kgamma, Pl3Kdelta, P13K-C2alpha, P13K-C2beta, P13K Vps34p". 30 43. Use according to Claim 40, wherein at least one enzyme is selected from the group consisting of: "Erk, Erk1, Erk2" and at least one enzyme is selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". W02007/054556 PCT/EP2006/068322 -501

44. Use according to Claim 40, wherein at least one enzyme is selected from the group consisting of: "Jnk, Jnkl, Jnk2, Jnk3, p38, p38alpha, p38beta, p38gamma, p38delta" and at least one enzyme is selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". 5

45. Use according to Claim 40, wherein at least one enzyme is selected from the group consisting of: "P13K, Pl3Kalpha, Pl3Kbeta, Pl3Kgamma, P13Kdelta, P13K-C2alpha, P13K-C2beta, PI3K-Vps34p" and at least one enzyme is selected from the group consisting of: "ATM, ATR, mTOR, DNA-PK, hSMG-1". 10

46. Use according to one of Claims 1 to 20, 25 to 45, wherein the modulation is an inhibition.

47. Use according to one of Claims 1 to 20, 26 to 46, wherein the mammal is selected 15 from the group consisting of: "humans, useful animals, livestock, domestic pets, beef cattle, cows, sheep, pigs, goats, horses, ponies, donkeys, hinnies, mules, hares, rabbits, cats, dogs, guinea pigs, hamsters, rats, mice" and is preferably a human. 20 48. Use according to one of Claims 1 to 20, 26 to 47, wherein the physiological and/or pathophysiological states are selected from the group consisting of: "malignant tumours, benign tumours, inflammatory disorders, inflammations, pain, rheumatic disorders, arthritic disorders, HIV infections, neurological or neurodegenerative disorders, rheumatism, arthritis, AIDS, ARC (AIDS related complex), Kaposi's 25 sarcoma, tumours emanating from the brain and/or nervous system and/or meninges, dementia, Alzheimer's, hyperproliferative disorders, psoriasis, endometriosis, scar formation, benign prostate hyperplasia (BPH), disorders of the immune system, autoimmune disorders, immune deficiency disorders, colon tumour, stomach tumour, intestine tumour, lung tumour, pancreas tumour, ovarial tumour, 30 prostate tumour, leukaemia, melanoma, liver tumour, kidney tumour, head tumour, throat tumour, glioma, breast tumour, uterine cancer, endometrial cancer, cervical cancer, brain tumour, adenocanthoma, bladder cancer, stomach tumor, colorectal tumour, oesophageal cancer, gynaecological tumour, ovarian tumour, thyroid cancer, W02007/054556 PCT/EP2006/068322 - 502 lymphoma, chronic leukaemia, acute leukaemia, restenosis, diabetes, diabetic nephropathy, fibrotic disorders, cystic fibrosis, malignant nephrosclerosis, thrombotic microangiopathy syndrome, organ transplant rejection, glomerulopathies, disorders of the metabolism, solid tumours, rheumatic arthritis, diabetic retinopathy, asthma, 5 allergies, allergic disorders, chronic obstructive pulmonary disorders, inflammatory bowel disorder, fibrosis, atherosclerosis, cardiac disorders, cardiovascular disorders, disorders of the heart muscle, vascular disorders, angiogenetic disorders, kidney disorders, rhinitis, Grave's disease, focal ischaemia, heart failure, ischaemia, cardiac hypertrophy, kidney failure, cardiac myocyte dysfunction, high blood pressure, 10 vascular constriction, stroke, anaphylactic shock, blood platelet agglutination, skeletal muscular atrophy, obesity, excess weight, glucose homeostasis, congestive heart failure, angina, heart attack, myocardial infarction, hyperglycaemia, hypoglycaemia, hypertension". 15 49. Use according to one of Claims 1 to 22, 24, 26 to 48, wherein the medicament comprises at least one further pharmacologically active substance.

50. Use according to one of Claims 1 to 22, 24, 26 to 48, wherein the medicament is administered before and/or during and/or after the treatment with at least one 20 further pharmacologically active substance.

51. Use according to one of Claims 1 to 22, 24, 26 to 48, wherein the medicament is administered before and/or during and/or after the treatment by radiation therapy and/or surgery. 25

52. Use according to one of Claims 49 to 50, wherein the further pharmacologically active substance is selected from the group consisting of: "DNA topoisomerase I and/or il inhibitors, DNA intercalators, alkylating agents, microtubuli destabilizers, hormone and/or growth factor receptor agonists and/or antagonists, antibodies 30 against growth factors and their receptors, kinase inhibitors, antimetabolites".

53. Use according to one of Claims 49, 50, 52, wherein the further pharmacologically active substance is selected from the group consisting of: "asparaginase, W02007/054556 PCT/EP2006/068322 -503 bleomycin, carboplatin, carmustine, chlorambucil, cisplatin, colaspase, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, doxorubicin (adriamycin), epirubicin, etoposide, 5-fluorouracil, hexamethylmelamine, hydroxyurea, ifosfamide, irinotecan, leucovorin, lomustine 5 mechlorethamine, 6-mercaptopurine, mesna, methotrexate, mitomycin C, mitoxantrone, prednisolone, prednisone, procarbazine, raloxifen, streptozocin, tamoxifen, thioguanine, topotecan, vinblastine, vincristine, vindesine, aminoglutethimide, L-asparaginase, azathioprine, 5-azacytidine cladribine, busulfan, diethylstilbestrol, 2',2'-difluorodeoxycytidine, docetaxel, 10 erythrohydroxynonyladenine, ethynylestradiol, 5-fluorodeoxyuridine, 5-fluorodeoxyuridine monophosphate, fludarabine phosphate, fluoxymesterone, flutamide, hydroxyprogesterone caproate, idarubicin, interferon, medroxyprogesterone acetate, megestrol acetate, melphalan, mitotane, paclitaxel, oxaliplatin, pentostatin, N-phosphonoacetyl-L-aspartate (PALA), plicamycin, 15 semustine, teniposide, testosterone propionate, thiotepa, trimethylmelamine, uridine, vinorelbine, epothilone, gemcitabine, taxotere, BCNU, CCNU, DTIC, 5-fluorouracil, herceptin, avastin, erbitux, sorafenib, gleevec, iressa, tarceva, rapamycin, actinomycin D". 20 54. Pharmaceutical composition which comprises a pharmacologically active amount of at least one compound according to one of Claims 1 to 20.

55. Pharmaceutical composition according to Claim 54, wherein the active ingredient is present in a unit dose of 0.001 mg to 100 mg per kg of body weight of a patient. 25

56. Pharmaceutical composition according to one of Claims 54 to 55, wherein the composition further comprises at least one pharmaceutically tolerated carrier and/or excipient. 30 57. Pharmaceutical composition according to one of Claims 54 to 56, wherein the composition comprises at least one further pharmacologically active ingredient. W02007/054556 PCT/EP2006/068322 - 504 58. Pharmaceutical composition according to Claim 57, wherein the further pharmacologically active substance is selected from the group consisting of: "DNA topoisomerase I and/or 11 inhibitors, DNA intercalators, alkylating agents, microtubuli destabilizers, hormone and/or growth factor receptor agonists and/or 5 antagonists, antibodies against growth factors and their receptors, kinase inhibitors, antimetabolites".

59. Pharmaceutical composition according to one of Claims 57 to 58, wherein the further pharmacologically active ingredient is selected from the group consisting of: 10 'asparaginase, bleomycin, carboplatin, carmustine, chlorambucil, cisplatin, colaspase, cyclophosphamide, cytarabine, dacarbazine, dactinomycin, daunorubicin, doxorubicin (adriamycin), epirubicin, etoposide, 5-fluorouracil, hexamethylmelamine, hydroxyurea, ifosfamide, irinotecan, leucovorin, lomustine mechlorethamine, 6-mercaptopurine, mesna, methotrexate, mitomycin C, 15 mitoxantrone, prednisolone, prednisone, procarbazine, raloxifen, streptozocin, tamoxifen, thioguanine, topotecan, vinblastine, vincristine, vindesine, aminoglutethimide, L-asparaginase, azathioprine, 5-azacytidine cladribine, busulfan, diethylstilbestrol, 2',2'-difluorodeoxycytidine, docetaxel, erythrohydroxynonyladenine, ethynylestradiol, 5-fluorodeoxyuridine, 20 5-fluorodeoxyuridine monophosphate, fludarabine phosphate, fluoxymesterone, flutamide, hydroxyprogesterone caproate, idarubicin, interferon, medroxyprogesterone acetate, megestrol acetate, melphalan, mitotane, paclitaxel, oxaliplatin, pentostatin, N-phosphonoacetyl-L-aspartate (PALA), plicamycin, semustine, teniposide, testosterone propionate, thiotepa, trimethylmelamine, 25 uridine, vinorelbine, epothilone, gemcitabine, taxotere, BCNU, CCNU, DTIC, 5-fluorouracil, herceptin, avastin, erbitux, sorafenib, gleevec, iressa, tarceva, rapamycin, actinomycin D".

60. Kit comprising a pharmacologically active amount of at least one compound 30 according to one of Claims 1 to 20 and a pharmacologically active amount of at least one further pharmacologically active ingredient according to one of Claims 57 to 59.