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NO20082511L - Novel pyridopyrazines and their use as kinase modulators - Google Patents

Novel pyridopyrazines and their use as kinase modulators

Info

Publication number
NO20082511L
NO20082511L NO20082511A NO20082511A NO20082511L NO 20082511 L NO20082511 L NO 20082511L NO 20082511 A NO20082511 A NO 20082511A NO 20082511 A NO20082511 A NO 20082511A NO 20082511 L NO20082511 L NO 20082511L
Authority
NO
Norway
Prior art keywords
kinase modulators
pyridopyrazines
novel
novel pyridopyrazines
malignant
Prior art date
Application number
NO20082511A
Other languages
Norwegian (no)
Inventor
Eckhard Guenther
Emmanuel Polymeropoulos
Irene Seipelt
Eckhard Claus
Michael Czech
Tilmann Schuster
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP05024693A external-priority patent/EP1785423A1/en
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of NO20082511L publication Critical patent/NO20082511L/en

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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Abstract

Det beskrives nye pyrido[2,3-b]pyrazinderivater med den generelle formel (I) og (II), deres fremstilling samt deres anvendelse som medikamenter. De finner særlig anvendelse for behandling av maligne og andre forstyrrelser som involverer patologisk celleproliferering.New pyrido [2,3-b] pyrazine derivatives of general formulas (I) and (II), their preparation and their use as drugs are described. They find particular application for the treatment of malignant and other disorders involving pathological cell proliferation.

NO20082511A 2005-11-11 2008-06-03 Novel pyridopyrazines and their use as kinase modulators NO20082511L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73569805P 2005-11-11 2005-11-11
EP05024693A EP1785423A1 (en) 2005-11-11 2005-11-11 Pyridopyrazine derivatives and their use as kinase modulators
US84976106P 2006-10-06 2006-10-06
PCT/EP2006/068322 WO2007054556A1 (en) 2005-11-11 2006-11-10 Novel pyridopyrazines and their use as modulators of kinases

Publications (1)

Publication Number Publication Date
NO20082511L true NO20082511L (en) 2008-06-24

Family

ID=37654792

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082511A NO20082511L (en) 2005-11-11 2008-06-03 Novel pyridopyrazines and their use as kinase modulators

Country Status (9)

Country Link
EP (1) EP1957487A1 (en)
JP (1) JP5527972B2 (en)
KR (1) KR101400905B1 (en)
AR (1) AR060010A1 (en)
AU (1) AU2006313701B2 (en)
CA (1) CA2628039A1 (en)
IL (1) IL191139A0 (en)
NO (1) NO20082511L (en)
WO (1) WO2007054556A1 (en)

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US8217042B2 (en) 2005-11-11 2012-07-10 Zentaris Gmbh Pyridopyrazines and their use as modulators of kinases
EP1990342A1 (en) * 2007-05-10 2008-11-12 AEterna Zentaris GmbH Pyridopyrazine Derivatives, Process of Manufacturing and Uses thereof
EP2170338A2 (en) * 2007-07-06 2010-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dna-pkcs modulates energy regulation and brain function
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GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
EP2508184A1 (en) 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazine derivatives and their use
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
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SI3122359T1 (en) 2014-03-26 2021-05-31 Astex Therapeutics Ltd. Combinations of an fgfr inhibitor and an igf1r inhibitor
JOP20200201A1 (en) 2015-02-10 2017-06-16 Astex Therapeutics Ltd Pharmaceutical compositions comprising n-(3,5-dimethoxyphenyl)-n'-(1-methylethyl)-n-[3-(1-methyl-1h-pyrazol-4-yl)quinoxalin-6-yl]ethane-1,2-diamine
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
HRP20201157T1 (en) 2015-09-23 2020-11-13 Janssen Pharmaceutica N.V. Tricyclic heterocycles for the treatment of cancer
LT3353164T (en) 2015-09-23 2022-01-25 Janssen Pharmaceutica, N.V. DIHETEROARYL REPLACED 1,4-BENZODIAZEPINES AND THEIR USE IN THE TREATMENT OF CANCER

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Also Published As

Publication number Publication date
KR101400905B1 (en) 2014-05-29
HK1126474A1 (en) 2009-09-04
IL191139A0 (en) 2008-12-29
CA2628039A1 (en) 2007-05-18
AU2006313701B2 (en) 2012-05-31
KR20080068117A (en) 2008-07-22
JP2009515853A (en) 2009-04-16
WO2007054556A1 (en) 2007-05-18
AR060010A1 (en) 2008-05-21
AU2006313701A1 (en) 2007-05-18
EP1957487A1 (en) 2008-08-20
JP5527972B2 (en) 2014-06-25

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