AU2005269016A1 - The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnics - Google Patents
The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnics Download PDFInfo
- Publication number
- AU2005269016A1 AU2005269016A1 AU2005269016A AU2005269016A AU2005269016A1 AU 2005269016 A1 AU2005269016 A1 AU 2005269016A1 AU 2005269016 A AU2005269016 A AU 2005269016A AU 2005269016 A AU2005269016 A AU 2005269016A AU 2005269016 A1 AU2005269016 A1 AU 2005269016A1
- Authority
- AU
- Australia
- Prior art keywords
- portulaca
- extracts
- aerial parts
- animals
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000284 extract Substances 0.000 title claims description 16
- 241001465754 Metazoa Species 0.000 title description 14
- 239000003814 drug Substances 0.000 title description 5
- 230000036642 wellbeing Effects 0.000 title 1
- 241000219295 Portulaca Species 0.000 claims description 21
- 241000196324 Embryophyta Species 0.000 claims description 10
- 244000234609 Portulaca oleracea Species 0.000 claims description 9
- 235000001855 Portulaca oleracea Nutrition 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 239000007952 growth promoter Substances 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000000969 carrier Substances 0.000 claims description 2
- 239000000399 hydroalcoholic extract Substances 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 description 10
- 239000003242 anti bacterial agent Substances 0.000 description 7
- 229940088710 antibiotic agent Drugs 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 6
- 239000000469 ethanolic extract Substances 0.000 description 6
- 241000282898 Sus scrofa Species 0.000 description 4
- 239000006030 antibiotic growth promoter Substances 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 244000144972 livestock Species 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 241000282412 Homo Species 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000009395 breeding Methods 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 108010078777 Colistin Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000006877 Insect Bites and Stings Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- XZNUGFQTQHRASN-XQENGBIVSA-N apramycin Chemical compound O([C@H]1O[C@@H]2[C@H](O)[C@@H]([C@H](O[C@H]2C[C@H]1N)O[C@@H]1[C@@H]([C@@H](O)[C@H](N)[C@@H](CO)O1)O)NC)[C@@H]1[C@@H](N)C[C@@H](N)[C@H](O)[C@H]1O XZNUGFQTQHRASN-XQENGBIVSA-N 0.000 description 1
- 229950006334 apramycin Drugs 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 229960003346 colistin Drugs 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000006052 feed supplement Substances 0.000 description 1
- 244000144993 groups of animals Species 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000002036 metaphylactic effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Husbandry (AREA)
- Diabetes (AREA)
- Food Science & Technology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Birds (AREA)
- Nutrition Science (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cultivation Receptacles Or Flower-Pots, Or Pots For Seedlings (AREA)
- Catching Or Destruction (AREA)
Description
WO 2006/013001 PCT/EP2005/007897 1 THE USE OF MEDICINAL PLANTS AND EXTRACTS THEREOF FOR THE WELL BEING OF ANIMALS IN VETERINARY MEDICINE AND ZOOTECHNICS The present invention relates to the use of extracts of aerial parts of plants of the Portulaca genus, in particular Portulaca oleracea, for the preparation of growth promoters for use in livestock. TECHNOLOGICAL BACKGROUND 5 Bacterial antibiotic resistance is an increasing problem which affects public health, including the veterinary field. The use in veterinary medicine of antibiotics that are mostly the same as or strictly related to those used in human medicine, and the established practice of use of antibiotics at sub-therapeutical doses as growth promoters 10 and mass metaphylactic agents, are the main causes of diffusion of acquired antibiotic resistance by a number of bacterial species responsible for pathologies in domestic animals and often even in .humans. The presence of antibiotic residues in meat and, indirectly, the selection of antibiotic-resistant bacteria, which can transfer the resistance genes to bacteria pathogenic to 15 humans, can be a hazard to human health. Approximately 25% of the total antibiotic production is intended for use in livestock, the 90% of them being used at sub-therapeutical doses for both the prevention of diseases and the promotion of growth. Antimicrobials have been added to feed and extensively used in zootechnics since the '50s to 20 improve productive performances. In swine breeding, for instance, weaning of piglets is the most delicate step, as the distressing events related to the transfer and mixing of different groups of animals and the changes of feed induce alterations in the intestinal microbial flora of the animal, making it more susceptible to infections. The use of antibiotics in the prophylaxis of endemic WO 2006/013001 PCT/EP2005/007897 2 diseases occurring during weaning has lead to a generalized use of antibiotics which are included in feed for times which can be protracted until the animal is even 70-80 day old. As a consequence of antibiotic-resistance emergency, the European 5 Union has followed a restricted approach concerning the use of antibiotics as growth promoters, antimicrobial prophylaxis, multi-therapies, mass medication through feed and water. In particular, EU is withdrawing all authorizations concerning the use of antibiotics as growth promoters by 2006. However, the prohibition of use of antibiotics as growth promoters and 10 prophylactic agents will involve a deterioration of animals health, with an increase in diarrhoea, weight loss and mortality. Different approaches exist for reducing the dependency of zootechnics, more particularly swine breeding, on the use of antibiotics: the choice one is the development of alternatives acting through the control of bacteria and 15 promoting the natural reactivity of the animal, thereby inducing an improvement in health as well as the optimization of performances. Mandatory characteristics for such alternative solutions are safety of use and cheapness for producers, and hence for consumers. Portulaca is a annual herbaceous plant present in all temperate and warm 20 regions. Aerial parts of plants of the Portulaca genus have been used for a long time, as they are or in the form of aqueous or water-ethanol extracts, in Chinese traditional medicine for arresting hemorrage of various origin (hemorrhoids, uterus), and for the treatment of sores, eczema, snake or insect bites. 25 DISCLOSURE OF THE INVENTION It has now been found that the administration of parts of plants, particularly the ground aerial parts or the extracts of the aerial parts of plants WO 2006/013001 PCT/EP2005/007897 3 of the Portulaca genus, in particular Portulaca oleracea, to livestock, is at least as much as active as the administration of growth-promoting antibiotics. Therefore, the present invention relates to compositions for the veterinary or zootechnical use, comprising as active ingredients aerial parts 5 ground or extracts of aerial parts of Portulaca, preferably Portulaca oleracea, admixed with suitable carriers or in the form of feed supplements. Said compositions proved capable of promoting growth in livestock, in particular swine, bovine, ovine and equine, more particularly swine, without inducing the drawbacks and side effects of growth-promoting antibiotics. 10 Dosages will depend on a number of factors, such as species, size, weight and age of the animal. In principle, a typical dosage will range from 0.1 g to 10 g of extract/aerial parts per animal/day. The extracts usable according to the invention can be prepared by a process which comprises the repeated extraction of Portulaca oleracea aerial 15 parts with a solvent, of preferably at room temperature. The solvent used for the extraction preferably consists of a hydro-alcoholic ethanol/water 1:1 mixture. The resulting extracts are combined and concentrated under reduced pressure. The following examples illustrate the invention in further detail. EXAMPLE 1: Portulaca oleracea aerial parts extract for the zootechnical 20 use Preparation of the extract 1000 g of dry ground aerial parts of Portulaca oleracea are placed in percolator. The material is covered with a mixture ethanol/water mixture 1:1 v/v and left at RT for 3 hours. The solvent is then percolated and the material is 25 covered with a further portion of ethanol/water mixture 1:1 v/v. The procedure is repeated 6 times using about 7700 ml of solvent totally. The 6 percolates are filtered, combined and concentrated under reduced pressure, thereby obtaining a dark hygroscopic grindable solid (241 g; yield 24.1% w/w).
WO 2006/013001 PCT/EP2005/007897 4 EXAMPLE 2: In vivo test Experiments were carried out on 120 piglets divided into 4 groups of 30 animals each. Group 1 (control) was treated with standard feed free from additives. 5 Group 2 (antibiotic) was treated with medicated feed containing 2 g of apramycin and 1 g of colistin per kg of feed. Group 3 was treated with standard feed added with 2 g/Kg of Portulaca extract. Group 4 was treated with standard feed added with 5 g/kg of finely ground Portulaca aerial parts. All animals were treated during weaning from day 22 to day 41. 10 The animal well being was evaluated by the total weight increase, the feed daily intake and the percentage of diarrhoeic animals. Moreover, from day 41, faeces samples were microbiologically analysed for bacterial counts of total mesophyte charge, total Coliform and Lactobacilli. All parameters were evaluated with standard methods known to those skilled in the art. 15 Results reported in the following Tables prove that the addition to standard feed of Portulaca in the form of both finely ground aerial parts and water-ethanol extract, although being devoid of per se in vitro antibacterial activity, can be a valuable replacement for antibiotic growth promoters in weaning foodstock. 20 Table 1. Piglets weights and Mean Weight Increase (MWI) on day 41. Treatment Piglets weight (kg) MWI day 22 day 41 Control 7.02± 1.2 10.25 ±1.5 3.22 Antibiotic 7.43 ± 1.3 12.21 ± 1.6 4.78 Portulaca aerial parts 7.12 1.1 11.33 ± 1.4 4.21 Portulaca water-ethanol extract 7.30 ± 1.2 11.79 ± 1.3 4.49 WO 2006/013001 PCT/EP2005/007897 5 Table 2. Mean daily intake: amount of feed daily intake, expressed in kg, between days 22 and 41 of treatment. Treatment kg Control -0.22 Antibiotic 0.37 Portulaca aerial parts 0.33 Portulaca water-ethanol extract 0.35 5 Table 3. Effect of treatment on diarrhoea onset in the various treated groups. Treatment % of animals with diarrhoea Control 60 Antibiotic 10 Portulaca aerial parts 30 Portulaca water-ethanol extract 20 Table 4. Effect of administration of the tested substances on different 10 bacterial populations (log Ufc/g) from faeces samples taken on day 41. Treatment E. Coli CBT Lactobacilli Antibiotic 6.41 6.47 5.38 Control 8.05 7.55 6.93 Portulaca aerial parts 6.93 6.99 6.91 Portulaca water-ethanol extract 6.50 6.73 6.90
Claims (7)
1. The use of parts or extracts of plants of the Portulaca genus for the preparation of growth promoters for feedstock. 5
2. The use as claimed in claim I wherein the plant of the Portulaca genus is Portulaca oleracea.
3. The use as claimed in claim 1 or 2 in which the parts of Portulaca are the aerial parts.
4. The use as claimed in claim 1 or 2 in which the extract is a aerial parts 10 hydro-alcoholic extract.
5. Veterinary or zootechnical compositions comprising parts or extracts of plants of the Portulaca genus in admixture with suitable carriers.
6. Compositions as claimed in claim 5 comprising aerial parts or extracts idro-alcholic of the aerial parts of Portulaca oleracea. 15
7. Feed added with aerial parts or aerial parts extracts of plants of the Portulaca genus, in particular Portulaca oleracea.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2004A001629 | 2004-08-06 | ||
| IT001629A ITMI20041629A1 (en) | 2004-08-06 | 2004-08-06 | USE OF MEDICINAL PLANTS AND THEIR EXTRACTS FOR ANIMAL WELFARE IN VETERINARY AND ZOOTECHNICS |
| PCT/EP2005/007897 WO2006013001A1 (en) | 2004-08-06 | 2005-07-20 | The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2005269016A1 true AU2005269016A1 (en) | 2006-02-09 |
Family
ID=35149346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005269016A Abandoned AU2005269016A1 (en) | 2004-08-06 | 2005-07-20 | The use of medicinal plants and extracts thereof for the well-being of animals in veterinary medicine and zootechnics |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1778257A1 (en) |
| JP (1) | JP2008509098A (en) |
| KR (1) | KR20070039114A (en) |
| CN (1) | CN101010092A (en) |
| AU (1) | AU2005269016A1 (en) |
| CA (1) | CA2576103A1 (en) |
| IL (1) | IL181161A0 (en) |
| IT (1) | ITMI20041629A1 (en) |
| NO (1) | NO20070661L (en) |
| RU (1) | RU2007104345A (en) |
| WO (1) | WO2006013001A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX354530B (en) * | 2013-02-27 | 2018-02-19 | Univ Autonoma Del Estado De Morelos | Compositions comprising immp for contributing to the development, growth and improvement of the productive parameters of animals of zootechnical interest, and use of same. |
| CN107397805B (en) * | 2017-07-07 | 2018-06-08 | 山东统盛医药科技有限公司 | Improve oral hygiene, prevention and the composition and preparation method for the treatment of mouth disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1053729A (en) * | 1990-02-05 | 1991-08-14 | 徐芝庭 | A kind of antimicrobial and preparation method thereof |
| JP2583382B2 (en) * | 1992-10-30 | 1997-02-19 | 中部飼料株式会社 | Livestock and poultry feed containing purslane |
| US5688508A (en) * | 1995-02-21 | 1997-11-18 | Virginia State University | Feed compositions comprising purslane leaves and methods of using thereof |
| CA2191923C (en) * | 1996-12-03 | 2000-10-24 | Ji-Won Yoon | Portulaca oleracea and tumor cell growth |
| CN1081445C (en) * | 1998-06-02 | 2002-03-27 | 归顺龙 | Additive for feed for piglets |
-
2004
- 2004-08-06 IT IT001629A patent/ITMI20041629A1/en unknown
-
2005
- 2005-07-20 AU AU2005269016A patent/AU2005269016A1/en not_active Abandoned
- 2005-07-20 JP JP2007524215A patent/JP2008509098A/en active Pending
- 2005-07-20 CA CA002576103A patent/CA2576103A1/en not_active Abandoned
- 2005-07-20 WO PCT/EP2005/007897 patent/WO2006013001A1/en not_active Ceased
- 2005-07-20 RU RU2007104345/13A patent/RU2007104345A/en not_active Application Discontinuation
- 2005-07-20 EP EP05768231A patent/EP1778257A1/en not_active Withdrawn
- 2005-07-20 CN CNA2005800265904A patent/CN101010092A/en active Pending
- 2005-07-20 KR KR1020077002506A patent/KR20070039114A/en not_active Abandoned
-
2007
- 2007-02-05 NO NO20070661A patent/NO20070661L/en not_active Application Discontinuation
- 2007-02-05 IL IL181161A patent/IL181161A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL181161A0 (en) | 2007-07-04 |
| JP2008509098A (en) | 2008-03-27 |
| CA2576103A1 (en) | 2006-02-09 |
| CN101010092A (en) | 2007-08-01 |
| NO20070661L (en) | 2007-03-06 |
| KR20070039114A (en) | 2007-04-11 |
| RU2007104345A (en) | 2008-08-10 |
| EP1778257A1 (en) | 2007-05-02 |
| ITMI20041629A1 (en) | 2004-11-06 |
| WO2006013001A1 (en) | 2006-02-09 |
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| Date | Code | Title | Description |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |