AU2003302106A1 - New tricyclic angiotensin ii agonists - Google Patents
New tricyclic angiotensin ii agonistsInfo
- Publication number
- AU2003302106A1 AU2003302106A1 AU2003302106A AU2003302106A AU2003302106A1 AU 2003302106 A1 AU2003302106 A1 AU 2003302106A1 AU 2003302106 A AU2003302106 A AU 2003302106A AU 2003302106 A AU2003302106 A AU 2003302106A AU 2003302106 A1 AU2003302106 A1 AU 2003302106A1
- Authority
- AU
- Australia
- Prior art keywords
- agonists
- new tricyclic
- angiotensin
- tricyclic angiotensin
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940123471 Angiotensin II agonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42793602P | 2002-11-21 | 2002-11-21 | |
| US60/427,936 | 2002-11-21 | ||
| PCT/GB2003/005037 WO2004046141A1 (en) | 2002-11-21 | 2003-11-19 | New tricyclic angiotensin ii agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2003302106A1 true AU2003302106A1 (en) | 2004-06-15 |
Family
ID=32326616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003302106A Abandoned AU2003302106A1 (en) | 2002-11-21 | 2003-11-19 | New tricyclic angiotensin ii agonists |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2003302106A1 (en) |
| WO (1) | WO2004046141A1 (en) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1482931B1 (en) | 2002-03-05 | 2011-10-19 | TransTech Pharma, Inc. | Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage |
| US8067418B2 (en) | 2005-04-12 | 2011-11-29 | Vicore Pharma Ab | Tricyclic angiotensin II agonists |
| ES2395194T3 (en) * | 2005-04-12 | 2013-02-11 | Vicore Pharma Ab | New tricyclic agonists of angiotensin II |
| JP5179349B2 (en) | 2005-04-12 | 2013-04-10 | ヴィコール・ファルマ・アーベー | Novel bicyclic angiotensin II agonist |
| CA2690226C (en) | 2007-06-20 | 2012-07-24 | Mitsubishi Tanabe Pharma Corporation | Novel malonic acid sulfonamide derivative and pharmaceutical use thereof |
| US8263630B2 (en) | 2008-02-12 | 2012-09-11 | Bristol-Myers Squibb Company | 1,2,3-triazoles as 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| JP5805646B2 (en) | 2009-09-30 | 2015-11-04 | ブイティーブイ・セラピューティクス・エルエルシー | Substituted imidazole derivatives for the treatment of Alzheimer's disease |
| WO2015152393A1 (en) | 2014-04-03 | 2015-10-08 | 国立研究開発法人国立循環器病研究センター | Medicine for suppressing malignant tumor metastasis |
| TW202140422A (en) | 2014-10-06 | 2021-11-01 | 美商維泰克斯製藥公司 | Modulators of cystic fibrosis transmembrane conductance regulator |
| ES2946970T3 (en) | 2016-03-31 | 2023-07-28 | Vertex Pharma | Transmembrane conductance regulator of cystic fibrosis modulators |
| BR112019006213A2 (en) | 2016-09-30 | 2019-06-18 | Vertex Pharma | cystic fibrosis transmembrane conductance regulator modulator, pharmaceutical compositions, treatment methods and process for making the modulator |
| RU2632005C1 (en) * | 2016-10-10 | 2017-10-02 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации ГБОУ ВПО ВолгГМУ МЗ РФ | N-(acetylsalicyloyl)pyrazol with cerebroprotector action in case of cerebral circulation insufficiency |
| LT3551622T (en) | 2016-12-09 | 2021-02-25 | Vertex Pharmaceuticals Incorporated | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| TWI668211B (en) * | 2017-02-23 | 2019-08-11 | 德商拜耳作物科學公司 | Method for preparing methyl 4-[(4,5-dihydro-3-methoxy-4-methyl-5-oxo-1h-1,2,4-triazol-1-yl)carbonyl)sulfamoyl]-5-methylthiophene-3-carboxylate |
| MA54105A (en) | 2017-06-08 | 2021-09-15 | Vertex Pharma | CYSTIC FIBROSIS TREATMENT METHODS |
| WO2019018395A1 (en) | 2017-07-17 | 2019-01-24 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| CA3071278A1 (en) | 2017-08-02 | 2019-02-07 | Vertex Pharmaceuticals Incorporated | Processes for preparing pyrrolidine compounds |
| TWI719349B (en) | 2017-10-19 | 2021-02-21 | 美商維泰克斯製藥公司 | Crystalline forms and compositions of cftr modulators |
| WO2019113476A2 (en) | 2017-12-08 | 2019-06-13 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| TWI810243B (en) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | Pharmaceutical compositions for treating cystic fibrosis |
| US11414439B2 (en) | 2018-04-13 | 2022-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| GB201913603D0 (en) | 2019-09-20 | 2019-11-06 | Vicore Pharma Ab | New compounds |
| GB201917327D0 (en) | 2019-11-28 | 2020-01-15 | Vicore Pharma Ab | New pharmaceutical use |
| PH12022552413A1 (en) | 2020-03-19 | 2024-01-08 | Vicore Pharma Ab | Novel compounds useful in the treatment and/or prevention of a disease, disorder or condition associated with angiotensin ii |
| GB202004094D0 (en) | 2020-03-20 | 2020-05-06 | Vicore Pharma Ab | New compounds and uses |
| GB202013721D0 (en) | 2020-09-01 | 2020-10-14 | Vicore Pharma Ab | New compounds |
| CA3212900A1 (en) | 2021-03-23 | 2022-09-29 | Tomas Fex | Selective angiotensin ii receptor ligands |
| GB202104038D0 (en) | 2021-03-23 | 2021-05-05 | Vicore Pharma Ab | New compounds |
| GB202104033D0 (en) | 2021-03-23 | 2021-05-05 | Vicore Pharma Ab | New compounds |
| AU2022306778A1 (en) | 2021-07-09 | 2024-01-18 | Vicore Pharma Ab | New selective angiotensin ii compounds |
| WO2023193733A1 (en) * | 2022-04-06 | 2023-10-12 | 武汉人福创新药物研发中心有限公司 | At2r agonist |
| EP4648850A1 (en) | 2023-01-09 | 2025-11-19 | Vicore Pharma AB | Selective angiotensin ii compounds |
| CN119504722A (en) * | 2023-08-25 | 2025-02-25 | 武汉人福创新药物研发中心有限公司 | A thiophenesulfonyl carbamate as AT2R agonist and its use |
| WO2025146172A1 (en) * | 2024-01-03 | 2025-07-10 | 武汉人福创新药物研发中心有限公司 | Fused ring compound as at2r agonist |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5262412A (en) * | 1993-03-10 | 1993-11-16 | Merck & Co., Inc. | Substituted pyrazoles, compositions and use |
| YU78601A (en) * | 1999-05-05 | 2005-07-19 | Aventis Pharma Deutschland Gmbh. | 1-(p-thienylbenzyl)-imidazoles as angiotensin-(1-7) receptor agonists, method for the production and the utilization thereof and pharmaceutical preparations containing said compounds |
-
2003
- 2003-11-19 AU AU2003302106A patent/AU2003302106A1/en not_active Abandoned
- 2003-11-19 WO PCT/GB2003/005037 patent/WO2004046141A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004046141A1 (en) | 2004-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |