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AU2003266272A1 - Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk) - Google Patents

Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk)

Info

Publication number
AU2003266272A1
AU2003266272A1 AU2003266272A AU2003266272A AU2003266272A1 AU 2003266272 A1 AU2003266272 A1 AU 2003266272A1 AU 2003266272 A AU2003266272 A AU 2003266272A AU 2003266272 A AU2003266272 A AU 2003266272A AU 2003266272 A1 AU2003266272 A1 AU 2003266272A1
Authority
AU
Australia
Prior art keywords
pyruvate kinase
tumour specific
peptide modulators
specific pyruvate
kinase subtype
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003266272A
Other versions
AU2003266272A8 (en
Inventor
Barbara Fitzky
Hendrik Pidder Jansen-Durr
Gilles Spoden
Werner Paul Zwerschke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMYNON BIO TECH GmbH
Original Assignee
AMYNON BIO TECH GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AMYNON BIO TECH GmbH filed Critical AMYNON BIO TECH GmbH
Publication of AU2003266272A8 publication Critical patent/AU2003266272A8/en
Publication of AU2003266272A1 publication Critical patent/AU2003266272A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0104—Pyruvate kinase (2.7.1.40)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2003266272A 2002-08-12 2003-08-11 Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk) Abandoned AU2003266272A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02017791 2002-08-12
EP02017791.1 2002-08-12
PCT/EP2003/008901 WO2004016646A2 (en) 2002-08-12 2003-08-11 Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk)

Publications (2)

Publication Number Publication Date
AU2003266272A8 AU2003266272A8 (en) 2004-03-03
AU2003266272A1 true AU2003266272A1 (en) 2004-03-03

Family

ID=31725344

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003266272A Abandoned AU2003266272A1 (en) 2002-08-12 2003-08-11 Peptide modulators of tumour specific pyruvate kinase subtype m2 (m2-pk)

Country Status (2)

Country Link
AU (1) AU2003266272A1 (en)
WO (1) WO2004016646A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3041868C (en) * 2008-10-09 2023-03-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bis sulfonamide piperazinyl and piperidinyl activators of human pyruvatekinase
CA2977976A1 (en) * 2015-02-26 2016-09-01 Proda Biotech Llc Molecules disrupting pyruvate kinase m2 and integrin interaction and uses thereof
MX2020010028A (en) * 2018-03-29 2020-10-14 Genentech Inc Modulating lactogenic activity in mammalian cells.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3838900A1 (en) * 1988-11-17 1990-05-23 Scheefers Borchel Ursula PYRUVATKINASE-ISOENZYM TYPE M2 (TUMOR M2-PK) SPECIFIC ANTIBODIES / METHOD FOR THE PRODUCTION AND USE THEREOF
ES2390530T3 (en) * 1996-07-15 2012-11-13 The Regents Of The University Of California Genes from amplicon 20Q13 and its uses
US6358683B1 (en) * 1999-06-03 2002-03-19 The Regents Of The University Of California Blood-based assays for breast cancer
DE10029131A1 (en) * 2000-06-14 2002-01-03 Ulf R Rapp New nucleic acid encoding protein kinase of the mitogenic signaling pathway, useful for identifying cytostatic agents, includes the sequence of a glycolytic enzyme binding site
DE10112926B4 (en) * 2001-03-13 2005-11-10 Schebo Biotech Ag Use of aminooxyacetate for tumor treatment
US20040152648A1 (en) * 2001-05-23 2004-08-05 Axel Ullrich Pyruvate-kinase as a novel target molecule

Also Published As

Publication number Publication date
AU2003266272A8 (en) 2004-03-03
WO2004016646A2 (en) 2004-02-26
WO2004016646A3 (en) 2004-12-16

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase