AU2003245030A1 - Novel process for production of the somatostatin analog, octreotide - Google Patents

Novel process for production of the somatostatin analog, octreotide

Info

Publication number: AU2003245030A1
Authority: AU; Australia
Prior art keywords: octreotide; production; novel process; somatostatin analog; somatostatin
Prior art date: 2002-05-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2003245030A

Inventor

Suresh Beri

Nishith C. Chaturvedi

Noel J. De Souza

Ravindra D. Yeole

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-22

Filing date

2003-04-16

Publication date

2003-12-02

2002-05-22 Priority claimed from US10/153,555 external-priority patent/US6987167B2/en

2003-04-16 Application filed by Individual filed Critical Individual

2003-12-02 Publication of AU2003245030A1 publication Critical patent/AU2003245030A1/en

Status Abandoned legal-status Critical Current

Links

DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 title 1
108010016076 Octreotide Proteins 0.000 title 1
229960002700 octreotide Drugs 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AU2003245030A 2002-05-22 2003-04-16 Novel process for production of the somatostatin analog, octreotide Abandoned AU2003245030A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US10/153,555		2002-05-22
US10/153,555 US6987167B2 (en)	2002-05-22	2002-05-22	Process for production of the somatostatin analog, octreotide
IN460/MUM/2002		2002-05-24
IN460MU2002		2002-05-24
PCT/IN2003/000160 WO2003097668A2 (en)	2002-05-22	2003-04-16	Novel process for production of the somatostatin analog, octreotide

Publications (1)

Publication Number	Publication Date
AU2003245030A1 true AU2003245030A1 (en)	2003-12-02

Family

ID=29551480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2003245030A Abandoned AU2003245030A1 (en)	2002-05-22	2003-04-16	Novel process for production of the somatostatin analog, octreotide

Country Status (3)

Country	Link
EP (1)	EP1506219A2 (en)
AU (1)	AU2003245030A1 (en)
WO (1)	WO2003097668A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2458084A1 (en) *	2004-03-12	2005-09-12	Dalton Chemical Laboratories Inc.	Novel process for octreotide synthesis
US8377891B2 (en)	2008-11-07	2013-02-19	Usv, Ltd.	Process for synthesis of cyclic octapeptide
RU2435780C1 (en) *	2010-07-08	2011-12-10	Закрытое Акционерное Общество "Фарм-Синтез"	Method for producing cyclic peptide-octreotide
WO2013132505A1 (en)	2012-03-09	2013-09-12	Natco Pharma Limited	Improved process for preparation of octreotide by solution phase peptide synthesis

2003
- 2003-04-16 WO PCT/IN2003/000160 patent/WO2003097668A2/en not_active Ceased
- 2003-04-16 AU AU2003245030A patent/AU2003245030A1/en not_active Abandoned
- 2003-04-16 EP EP03738490A patent/EP1506219A2/en not_active Withdrawn

Also Published As

Publication number	Publication date
EP1506219A2 (en)	2005-02-16
WO2003097668A3 (en)	2004-03-25
WO2003097668A2 (en)	2003-11-27

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Legal Events

Date	Code	Title	Description
2005-03-10	MK6	Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase