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AU2003219592A1 - Chiral intermediate and process for the production thereof - Google Patents

Chiral intermediate and process for the production thereof

Info

Publication number
AU2003219592A1
AU2003219592A1 AU2003219592A AU2003219592A AU2003219592A1 AU 2003219592 A1 AU2003219592 A1 AU 2003219592A1 AU 2003219592 A AU2003219592 A AU 2003219592A AU 2003219592 A AU2003219592 A AU 2003219592A AU 2003219592 A1 AU2003219592 A1 AU 2003219592A1
Authority
AU
Australia
Prior art keywords
production
chiral intermediate
chiral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003219592A
Inventor
Kwang-Min Lim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CLS LABORATORIES Inc
Original Assignee
CLS LAB Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CLS LAB Inc filed Critical CLS LAB Inc
Publication of AU2003219592A1 publication Critical patent/AU2003219592A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2003219592A 2002-04-09 2003-04-09 Chiral intermediate and process for the production thereof Abandoned AU2003219592A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2002-0019340 2002-04-09
KR10-2002-0019340A KR100511533B1 (en) 2002-04-09 2002-04-09 CHIRAL INTERMEDIATE, PROCESS FOR THE PRODUCTION THEREOF, AND PROCESS FOR THE PRODUCTION OF HMG-CoA REDUCTASE INHIBITOR
PCT/KR2003/000707 WO2003087112A1 (en) 2002-04-09 2003-04-09 Chiral intermediate and process for the production thereof

Publications (1)

Publication Number Publication Date
AU2003219592A1 true AU2003219592A1 (en) 2003-10-27

Family

ID=29244717

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003219592A Abandoned AU2003219592A1 (en) 2002-04-09 2003-04-09 Chiral intermediate and process for the production thereof

Country Status (3)

Country Link
KR (1) KR100511533B1 (en)
AU (1) AU2003219592A1 (en)
WO (1) WO2003087112A1 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011120D0 (en) 2000-05-09 2000-06-28 Avecia Ltd Process
NL1015744C2 (en) 2000-07-19 2002-01-22 Dsm Nv Process for the preparation of 2- (6-substituted-1,3-dioxan-4-yl) acetic acid derivatives.
IL159741A0 (en) 2001-07-13 2004-06-20 Astrazeneca Uk Ltd Preparation of aminopyrimidine compounds
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
NZ540722A (en) 2002-12-16 2008-03-28 Astrazeneca Uk Ltd Process for the preparation of pyrimidine compounds and intermediates thereof
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
EP1562912A2 (en) 2003-08-28 2005-08-17 Teva Pharmaceutical Industries Limited Process for preparation of rosuvastatin calcium
UY28501A1 (en) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd CHEMICAL COMPOUNDS
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
WO2005051921A1 (en) 2003-11-24 2005-06-09 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
PT1689723E (en) 2003-12-02 2011-07-06 Teva Pharma Reference standard for characterization of rosuvastatin
WO2005054207A1 (en) 2003-12-04 2005-06-16 Glenmark Pharmaceuticals Limited Process for the preparation of pyrimidine derivatives
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US7179916B2 (en) 2004-07-13 2007-02-20 Teva Pharmaceutical Industries Ltd. Process for the preparation of rosuvastatin
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
CA2680693A1 (en) * 2005-02-22 2006-08-31 Teva Pharmaceutical Industries Ltd. Preparation of rosuvastatin
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
KR100686186B1 (en) * 2005-06-13 2007-02-26 영진종합건설 주식회사 Bridge drainage structure
EP1805148A2 (en) * 2005-08-16 2007-07-11 Teva Pharmaceutical Industries Ltd. Crystalline rosuvastatin intermediate
KR101019450B1 (en) * 2005-10-03 2011-03-07 테바 파마슈티컬 인더스트리즈 리미티드 Diastereoisomer Purification of Rosuvastatin
MX2007006647A (en) * 2005-10-04 2007-07-25 Teva Pharma Preparation of rosuvastatin.
EP2172471B1 (en) 2007-04-18 2013-03-27 Teva Pharmaceutical Industries, Ltd. A process for preparing intermediates of HMG-CoA reductase inhibitors
WO2009009152A1 (en) 2007-07-12 2009-01-15 Teva Pharmaceutical Industries Ltd. Rosuvastatin intermediates and their preparation
US20110065920A1 (en) 2007-08-28 2011-03-17 Ratiopharm Gmbh Process for preparing pentanoic diacid derivatives
CA2725052C (en) 2008-05-27 2014-09-16 Changzhou Pharmaceutical Factory Co., Ltd. Preparation method of rosuvastatin calcium and its intermediates
KR101160152B1 (en) * 2009-02-24 2012-06-27 한미사이언스 주식회사 Novel process for preparing statin compound or its salt and intermediate used therein
KR101157314B1 (en) 2009-06-05 2012-06-15 주식회사종근당 New preparation of Rosuvastatin, the useful intermediates thereof and preparation of the same
WO2011106546A1 (en) 2010-02-25 2011-09-01 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin intermediate
EP2383260A3 (en) * 2010-04-30 2011-12-28 Dipharma Francis S.r.l. Process for the preparation of statins
ITMI20110397A1 (en) * 2011-03-14 2012-09-15 Dipharma Francis Srl PROCEDURE FOR THE PREPARATION OF PYAVASTATIN AND ANALOGUES
ITMI20100753A1 (en) * 2010-04-30 2011-10-31 Dipharma Francis Srl PROCEDURE FOR THE PREPARATION OF STATINES
WO2011141934A1 (en) 2010-05-13 2011-11-17 Matrix Laboratories Ltd. An improved process for the preparation of an intermediate of hmg-coa reductase inhibitors
CN102212081B (en) * 2010-12-30 2013-11-13 华润双鹤药业股份有限公司 Preparation method of chiral intermediate product for synthesis of statins
CN102584717B (en) * 2011-01-17 2014-12-10 浙江九洲药业股份有限公司 Intermediate for preparing rosuvastatin and preparation method and application thereof
CN102816114B (en) * 2011-06-09 2014-01-29 上海京新生物医药有限公司 Preparation method of HMG-CoA reductase inhibitor
JP6181063B2 (en) 2011-11-28 2017-08-16 マイラン ラボラトリーズ リミテッドＭｙｌａｎ Ｌａｂｏｒａｔｏｒｉｅｓ Ｌｉｍｉｔｅｄ Novel process for producing intermediates of HMG-CoA reductase inhibitors
ITVI20130039A1 (en) * 2013-02-20 2014-08-21 F I S Fabbrica Italiana Sint I S P A PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR STATIN SYNTHESIS
KR101710976B1 (en) * 2015-04-08 2017-02-28 임광민 Method for preparing of chiral intermediate and method for the preparing of HMG-CoA reductase inhibitor using chiral intermadiate
CN116606314B (en) * 2023-05-30 2025-08-05 江苏阿尔法药业股份有限公司 A synthesis process for high-purity pitavastatin calcium intermediate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804770A (en) * 1988-04-29 1989-02-14 E. R. Squibb & Sons, Inc. Process for preparing a keto-phosphonate intermediate useful in preparing HMG-CoA reductase inhibitors
US5354879A (en) * 1991-06-19 1994-10-11 Shionogi Seiyaku Kabushiki Kaisha Optically active intermediate and method for production thereof
JP3149265B2 (en) * 1992-05-12 2001-03-26 鐘淵化学工業株式会社 Method for producing optically active 3,5-dihydroxy fatty acid ester derivative
JPH06107673A (en) * 1992-08-12 1994-04-19 Nissan Chem Ind Ltd New 3-hydroxy-5-hexanoic acid derivative

Also Published As

Publication number Publication date
KR100511533B1 (en) 2005-08-31
WO2003087112A1 (en) 2003-10-23
KR20030080620A (en) 2003-10-17

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase