AU2002318865B2 - Dental compositions containing hyaluronic acid - Google Patents
Dental compositions containing hyaluronic acid Download PDFInfo
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- AU2002318865B2 AU2002318865B2 AU2002318865A AU2002318865A AU2002318865B2 AU 2002318865 B2 AU2002318865 B2 AU 2002318865B2 AU 2002318865 A AU2002318865 A AU 2002318865A AU 2002318865 A AU2002318865 A AU 2002318865A AU 2002318865 B2 AU2002318865 B2 AU 2002318865B2
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- AU
- Australia
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- dental
- hyaluronic acid
- bleaching
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- Ceased
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- 239000000203 mixture Substances 0.000 title claims description 23
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title description 13
- 229920002674 hyaluronan Polymers 0.000 title description 11
- 229960003160 hyaluronic acid Drugs 0.000 title description 11
- 238000004061 bleaching Methods 0.000 claims description 25
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 10
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 10
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 8
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 8
- 230000035945 sensitivity Effects 0.000 claims description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 235000010333 potassium nitrate Nutrition 0.000 claims description 4
- 239000004323 potassium nitrate Substances 0.000 claims description 4
- 239000011775 sodium fluoride Substances 0.000 claims description 4
- 235000013024 sodium fluoride Nutrition 0.000 claims description 4
- 229940078916 carbamide peroxide Drugs 0.000 claims description 3
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 3
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 1
- 229910002651 NO3 Inorganic materials 0.000 claims 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 239000003975 dentin desensitizing agent Substances 0.000 claims 1
- 229940014041 hyaluronate Drugs 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000000499 gel Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000002087 whitening effect Effects 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 210000004268 dentin Anatomy 0.000 description 4
- 210000005239 tubule Anatomy 0.000 description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- 201000002170 dentin sensitivity Diseases 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000036347 tooth sensitivity Effects 0.000 description 3
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 2
- 229910002014 Aerosil® 130 Inorganic materials 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- DWJSYDSSUAFIFO-UHFFFAOYSA-N OCC(O)CO.[N+](=O)([O-])[O-].[K+] Chemical compound OCC(O)CO.[N+](=O)([O-])[O-].[K+] DWJSYDSSUAFIFO-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- -1 Tungsten Halogen Chemical class 0.000 description 2
- 229920001222 biopolymer Polymers 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- QOSATHPSBFQAML-UHFFFAOYSA-N hydrogen peroxide;hydrate Chemical compound O.OO QOSATHPSBFQAML-UHFFFAOYSA-N 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 238000006664 bond formation reaction Methods 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 239000005548 dental material Substances 0.000 description 1
- 210000004262 dental pulp cavity Anatomy 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229920000554 ionomer Polymers 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 210000005067 joint tissue Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 210000001640 nerve ending Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940057847 polyethylene glycol 600 Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229940093928 potassium nitrate Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
AUSTRALIA
Patents Act 1990 COMPLETE
SPECIFICATION
STANDARD
PATENT
DENTAL BLEACHING
COMPOSITIONS
CONTAINING
HYALURONIC ACID DERIVATIVES The following statement is description of this invention, the best method of performing to me: a full including it known DENTAL BLEACHING COMPOSITIONS CONTAINING HYALURONIC ACID DERIVATIVES SThis invention relates to bleaching compositions intended for: The actual tooth bleaching process involved in both Take Home and In- Office systems.
The prevention of tooth sensitivity often encountered during bleaching by treating before and/or after bleaching.
0 Tooth sensitivity can be inherited, or caused by sickness, poor dental hygiene 00 or by poorly formulated peroxide bleaching agents. It is well known that bleaching systems will cause tooth whitening after exposure. The whitening action is believed to involve oxygen radicals released by the decomposing bleaching agent usually a peroxide. These radicals permeate into the tooth Sthrough the enamel and dentine attacking color-causing molecules and Soxidizing them into colourless ones, thus causing the whitening effect.
Although not proven it is believed that during the bleaching process some of the oxygen radicals reach the pulp chamber through open dentinal tubules irritating the very sensitive nerve endings known as the pain fibres. Many toothpastes contain desensitizers such as potassium nitrate to reduce sensitivity via chemical interference, directly resulting in a calming effect on the tooth. Patients that use these products often experience intense tissue bum as a side effect. Another method of reducing sensitivity is to use fluoride formulations to block the tubules. This method is often avoided simply because of fear of fluoride. Many believe that fluoride is being overused in everything including water. A distinct disadvantage of the desensitizing toothpaste is insufficient permeation time and low concentration.
These problems are overcome by the present invention which provides dental materials such as: Tooth bleaching gel for the Take Home Treatment Tooth bleaching gel for the In-Office Treatment.
Powder and liquid bleaching gel systems for the In-Office Treatment The prevention of tooth sensitivity often encountered during bleaching using either In-Office or Take Home Treatments.
Sodium Hyaluronate (also known as Hyaluronic Acid) is a natural substance S found in the space surrounding all cells with the highest concentrations found in the soft connective tissue such as the skin and cartilage. It plays an c important role in maintaining and regulating the water balance of tissue and facilitating the transport of nutrients and waste. As a major component of joint tissue, Hyaluronic Acid presence influences the hydration of cartilage which is necessary for its resilience and elastic strength.
Hyaluronic Acid is well known for its ability to stimulate production of healthy new tissue in half the time by increasing the blood supply and reducing inflammation. This ability is often referred to as healing power and it is utilized OC often in Orthopedics, and Ophthalmology. The Cosmetic Industry uses 0o Hyaluronic Acid because of its excellent property of moisturization to give Slubricity to the human skin, utilizing absorption and water holding properties.
The mechanism of the desensitizing properties of Hyaluronic Acid and its salts Sis easily understood after carefully studying the chemical structure of SHyaluronic Acid. It is a polysaccharide of alternating D-glucuronic acid and Nacetylglucosamine units.
Sodium Hyaluronate CAS Number 9067-32-7 When incorporated into aqueous dental compositions within the scope of this invention, hydrogen bond formation occurs between water molecules and carboxyl and N-acetyl groups resulting in a stiffer biopolymer of limited flexibility. This biopolymer is effectively a flexible membrane which ionically bonds to dentine thus sealing the tubules and preventing irritants from entering the pulpal chamber via the tubules. The ionic reaction involves the ionised carboxyl group bonding to both collagen and inorganic dentine in the same way as modem dentine adhesives and glass ionomers.
The Hyaluronic Acid is capable of forming these membrane even in very dilute solutions up to six litres of water may be found per gram of Hyaluronic Acid resulting in very viscous gels.
Hyaluronic Acid may be in the form of sodium or potassium salt.
The average molecular weight of the Hyaluronic Acid within the scope of this invention ranges from 70,000 Da to 5 MDa.
The Hyaluronic Acid may be combined with potassium nitrate and sodium fluoride for synergistic results.
In order to more clearly illustrate the parameters of the inventive dental composition within the scope of the present invention, the following examples are presented. The following examples are intended to be exemplary and should not be viewed as limiting to the scope of the invention.
Example 1 A Take Home tooth bleaching gel with desensitising action within the scope of the present invention was prepared by combining the following proportions:
O
IoD 00 00 Ingredients Water Sodium Hyaluronate AQUPEC HV-504 Sodium Hydroxide (40% Solution) Polyethylene Glycol 400 Hydrogen Peroxide Flavour Glycerine Welaht Percent 20.0 4.2 15.0 49.8 The Aquepec HV-504 was obtained from Sumitomo Seika Chiyodaku Tokyo.
Aquepec HV-504 was combined with glycerine before mixing with water. The Sodium Hyaluronate and polyethylene glycol were added to the homogeneous mixture next. After stirring the formulation was neutralized with sodium hydroxide. Flavour and hydrogen peroxide were added last.
The above formulation was applied to the upper arch of ten volunteers, one hour per day, for two weeks, with no evidence of any sensitivity and excellent tooth whitening results.
Example 2 A Take Home tooth bleaching gel with desensitising action within the scope of the present invention was prepared by combining the following proportions: Ingredients Water Sodium Hyaluronate Carbopol 974 P NF* Sodium Hydroxide (40% Solution) Polyethylene Glycol 400 Carbamide Peroxide Flavour Glycerine Potassium Nitrate Weight Percent 20.0 0.8 15.0 10.0 45.2 B.F. Goodrich Company
I
As for Example 1, the carbopol 974P NF was combined with glycerine prior to mixing with water. The Sodium Hyaluronate, polyethylene glycol 400 and potassium nitrate were added next. The flavour and carbamide peroxide were added last.
The above formulation was tested on the lower arch of the same volunteers as in Example 1, for one hour per day for two weeks with no evidence of any sensitivity and excellent tooth whitening results.
Example 3 A Take Home bleaching gel with desensitizing action as for Example 2 which also includes 1.0% sodium fluoride.
Example 4 An In-Office bleaching gel with desensitizing action within the scope of the present invention was prepared by combining the following proportions: Ingredients Water Sodium Hyaluronate Carbopol 940* Sodium Hydroxide (40% Solution) Polyethylene glycol 600 Hydrogen Peroxide Flavour Glycerine Potassium Nitrate Wavelength Sensitive Dye Weight Percent 20.0 0.6 15.0 35.0 18.8 0.1 B.F. Goodrich Company The above formulation was tested on the upper arch of ten new volunteers that were never exposed to bleaching before. This treatment involved four passes over 30 minutes. Each tooth was activated for 30 seconds with a Tungsten Halogen light. Again no sensitivity was reported with excellent tooth whitening results.
Example An In-Office powder and liquid bleaching gel with desensitizing action within the scope of the present invention was prepared by combining the following proportions: Powder Component Ingredients Degussa Aerosil 130 Sodium Hyaluronate Sodium Carbonate Wavelength Sensitive Dye Weight Percent 97.89 0.1 0.01 Liquid Component Ingredients Hydrogen Peroxide Water Weight Percent 35.0 65.0 The above composition was tested at a ratio of 0.3 powder weight, using the lower arch of the volunteers in Example 4.
whitening results were excellent and no sensitivity was reported.
2 liquid by The tooth Example 6 An In-Office Powder and Liquid bleaching gel with desensitizing action within the scope of the present invention was prepared by combining the following proportions: Powder Component Ingredients Degussa Aerosil 130 Sodium Hyaluronate Sodium Carbonate Potassium Nitrate Sodium Fluoride Wavelength Sensitive Dye Liquid Component Ingredients Hydrogen Peroxide Water Weight Percent 95.09 0.2 0.2 0.01 Weight Percent 35.0 65.0 The above composition was tested at a ratio of 0.3 powder: 2 liquid by weight using both arches of five new volunteers. The tooth whitening results were excellent and no sensitivity was reported.
Claims (4)
1. A dental bleaching composition that prevents sensitivity during the tooth bleaching process containing either Hydrogen peroxide or Carbamide peroxide in an amount ranging from 16%wt to 50%wt of the composition. This composition also contains Sodium Hyaluronate in an amount ranging from 0.05%wt to r
2. A dental bleaching composition as defined in claim 1 wherein the oO desensitizing agent is Potassium Hyaluronate is included in an amount 00 ranging from 0.005% by weight to about 6% by weight of the dental composition.
S3. A dental bleaching composition as defined in claim 1 further including Spotassium nitrate in an amount ranging from 0.1% by weight to 5% by cl weight of the dental composition.
4. A dental bleaching composition as defined in claim 1 further including sodium fluoride in an amount ranging from 0.1% by weight to 1% by weight of the dental composition. A dental bleaching composition as defined in claim 1 further including potassium nitrate in amount ranging from 0.1% by weight to 5% by weight and sodium fluoride in an amount ranging from 0.1% to 1% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002318865A AU2002318865B2 (en) | 2002-12-10 | 2002-12-10 | Dental compositions containing hyaluronic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2002318865A AU2002318865B2 (en) | 2002-12-10 | 2002-12-10 | Dental compositions containing hyaluronic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002318865A1 AU2002318865A1 (en) | 2004-06-24 |
| AU2002318865B2 true AU2002318865B2 (en) | 2007-08-02 |
Family
ID=34280495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002318865A Ceased AU2002318865B2 (en) | 2002-12-10 | 2002-12-10 | Dental compositions containing hyaluronic acid |
Country Status (1)
| Country | Link |
|---|---|
| AU (1) | AU2002318865B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018011990A (en) | 2016-04-01 | 2019-02-13 | Procter & Gamble | Oral care compositions containing potassium nitrate and peroxide. |
| US10758461B2 (en) | 2016-04-01 | 2020-09-01 | The Procter & Gamble Company | Oral care compositions containing a gel network phase and potassium nitrate |
| BR112018069957A2 (en) | 2016-04-01 | 2019-02-05 | Procter & Gamble | mouthwash compositions containing potassium nitrate gel nets |
| WO2017173198A1 (en) | 2016-04-01 | 2017-10-05 | The Procter & Gamble Company | Oral care compositions containing a gel network phase |
| CN112107509B (en) * | 2020-09-25 | 2022-11-15 | 山东华熙海御生物医药有限公司 | Tooth whitening paste containing hyaluronic acid and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002030380A1 (en) * | 2000-10-13 | 2002-04-18 | Block Drug Company, Inc. | Dental compositions for hypersensitive teeth |
-
2002
- 2002-12-10 AU AU2002318865A patent/AU2002318865B2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002030380A1 (en) * | 2000-10-13 | 2002-04-18 | Block Drug Company, Inc. | Dental compositions for hypersensitive teeth |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002318865A1 (en) | 2004-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of applicant's name (sec. 104) |
Owner name: MAESTRO DENTAL & COSMETICS PTY LTD Free format text: FORMER NAME: MAESTRO COSMETICS INTERNATIONAL P/L |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |