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AU2002314026A1 - Method for the production of zolpidem - Google Patents

Method for the production of zolpidem

Info

Publication number
AU2002314026A1
AU2002314026A1 AU2002314026A AU2002314026A AU2002314026A1 AU 2002314026 A1 AU2002314026 A1 AU 2002314026A1 AU 2002314026 A AU2002314026 A AU 2002314026A AU 2002314026 A AU2002314026 A AU 2002314026A AU 2002314026 A1 AU2002314026 A1 AU 2002314026A1
Authority
AU
Australia
Prior art keywords
compound
formula
production
zolpidem
coch3
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002314026A
Inventor
Markus Sauter
Wolfgang Wohlleben
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Publication of AU2002314026A1 publication Critical patent/AU2002314026A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a method for the production of a compound of formula (I), wherein a compound of formula (II), in which R<1> represents chlorine, bromine, iodine, -O-COCH3, -tosylate or -mesylate, is reacted with a compound of formula (III), optionally in a suitable diluting agent and/or in the presence of a suitable additional reactant or catalyst, wherein the reaction is carried out at a temperature ranging from 20 to 80 DEG C.
AU2002314026A 2001-05-03 2002-05-02 Method for the production of zolpidem Abandoned AU2002314026A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10121638A DE10121638A1 (en) 2001-05-03 2001-05-03 Process for the preparation of imidazopyridines
DE10121638.6 2001-05-03
PCT/EP2002/004796 WO2002090356A2 (en) 2001-05-03 2002-05-02 Method for the production of zolpidem

Publications (1)

Publication Number Publication Date
AU2002314026A1 true AU2002314026A1 (en) 2002-11-18

Family

ID=7683572

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002314026A Abandoned AU2002314026A1 (en) 2001-05-03 2002-05-02 Method for the production of zolpidem

Country Status (9)

Country Link
EP (1) EP1395586B1 (en)
JP (1) JP2004528380A (en)
AT (1) ATE353896T1 (en)
AU (1) AU2002314026A1 (en)
CA (1) CA2445766A1 (en)
DE (2) DE10121638A1 (en)
ES (1) ES2280550T3 (en)
MX (1) MXPA03010034A (en)
WO (1) WO2002090356A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1370515A2 (en) 2000-08-29 2003-12-17 Ranbaxy Laboratories, Ltd. Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem
EP1660496A1 (en) * 2003-07-31 2006-05-31 Ranbaxy Laboratories Limited Process for the synthesis of zolpidem
US20080262025A1 (en) * 2004-07-16 2008-10-23 Yatendra Kumar Processes for the Preparation of Zolpidem and its Hemitartrate
CN101277959A (en) * 2005-10-03 2008-10-01 马林克罗特公司 Process for the preparation of zolpidem hemitartrate and tartrate polymorphs
CA2654445A1 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
CN110272414B (en) * 2018-03-14 2020-07-17 新发药业有限公司 Preparation method of zolpidem
CN109336756B (en) * 2018-11-20 2021-05-11 河南大学 Hydrogenation dehalogenation method of halogenated aromatic hydrocarbon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2600650B1 (en) * 1986-06-27 1988-09-09 Synthelabo PROCESS FOR THE PREPARATION OF IMIDAZOPYRIDINES AND INTERMEDIATE COMPOUNDS

Also Published As

Publication number Publication date
JP2004528380A (en) 2004-09-16
ATE353896T1 (en) 2007-03-15
ES2280550T3 (en) 2007-09-16
WO2002090356A2 (en) 2002-11-14
EP1395586A2 (en) 2004-03-10
MXPA03010034A (en) 2004-02-27
EP1395586B1 (en) 2007-02-14
CA2445766A1 (en) 2002-11-14
DE10121638A1 (en) 2002-11-14
DE50209490D1 (en) 2007-03-29
WO2002090356A3 (en) 2003-12-24

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase