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AU2001256253A1 - Chemical process - Google Patents

Chemical process

Info

Publication number
AU2001256253A1
AU2001256253A1 AU2001256253A AU5625301A AU2001256253A1 AU 2001256253 A1 AU2001256253 A1 AU 2001256253A1 AU 2001256253 A AU2001256253 A AU 2001256253A AU 5625301 A AU5625301 A AU 5625301A AU 2001256253 A1 AU2001256253 A1 AU 2001256253A1
Authority
AU
Australia
Prior art keywords
compound
acid addition
addition salt
chemical process
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001256253A
Inventor
David Colclough
Anne Hodgson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AU2001256253A1 publication Critical patent/AU2001256253A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

A process for the preparation of the compound (I) or an acid addition salt thereof which comprises reacting a compound of formula (II), wherein R is an optionally substituted benzyl group under concomitant reduction and hydrogenolysis conditions, followed, if required, by isolation of the compound as an acid addition salt thereof.
AU2001256253A 2000-04-05 2001-04-04 Chemical process Abandoned AU2001256253A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0008179.4A GB0008179D0 (en) 2000-04-05 2000-04-05 Chemical process
GB0008179 2000-04-05
PCT/EP2001/003820 WO2001077143A2 (en) 2000-04-05 2001-04-04 Process for the preparation of 3-amino-1, 5-benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
AU2001256253A1 true AU2001256253A1 (en) 2001-10-23

Family

ID=9889106

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001256253A Abandoned AU2001256253A1 (en) 2000-04-05 2001-04-04 Chemical process

Country Status (9)

Country Link
US (1) US6673921B2 (en)
EP (1) EP1268517B1 (en)
JP (1) JP2003530404A (en)
AT (1) ATE299147T1 (en)
AU (1) AU2001256253A1 (en)
DE (1) DE60111834T2 (en)
ES (1) ES2241817T3 (en)
GB (1) GB0008179D0 (en)
WO (1) WO2001077143A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY156226A (en) 2008-02-22 2016-01-29 Otsuka Pharma Co Ltd Benzodiazepine compound and pharmaceutical composition
JP5649577B2 (en) * 2009-08-21 2015-01-07 大塚製薬株式会社 Process for producing benzo [b] [1,4] diazepine-2,4-dione compound
TWI481601B (en) 2009-08-21 2015-04-21 Otsuka Pharma Co Ltd Nitrogen-containing compound and pharmaceutical composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2641280B1 (en) * 1988-12-29 1994-01-21 Roussel Uclaf NOVEL 2,4-DIOXO 2,3,4,5-TETRAHYDRO 1H-1,5-BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
GB9308421D0 (en) 1993-04-23 1993-06-09 Glaxo Spa Chemical compounds
JP3621416B2 (en) * 1993-12-28 2005-02-16 塩野義製薬株式会社 Novel benzodiazepine derivatives
US5691331A (en) 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides

Also Published As

Publication number Publication date
DE60111834D1 (en) 2005-08-11
WO2001077143A3 (en) 2002-01-24
US20030158082A1 (en) 2003-08-21
EP1268517A2 (en) 2003-01-02
US6673921B2 (en) 2004-01-06
ES2241817T3 (en) 2005-11-01
ATE299147T1 (en) 2005-07-15
JP2003530404A (en) 2003-10-14
WO2001077143A2 (en) 2001-10-18
GB0008179D0 (en) 2000-05-24
DE60111834T2 (en) 2006-04-27
EP1268517B1 (en) 2005-07-06

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