[go: up one dir, main page]

AU2002362603A1 - 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors - Google Patents

3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors

Info

Publication number
AU2002362603A1
AU2002362603A1 AU2002362603A AU2002362603A AU2002362603A1 AU 2002362603 A1 AU2002362603 A1 AU 2002362603A1 AU 2002362603 A AU2002362603 A AU 2002362603A AU 2002362603 A AU2002362603 A AU 2002362603A AU 2002362603 A1 AU2002362603 A1 AU 2002362603A1
Authority
AU
Australia
Prior art keywords
thiazoles
isoquinolinyl
pyridyl
lyase inhibitors
lyase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002362603A
Inventor
Furahi Achebe
Davoud Asgari
Cheng Bi
Donald Bierer
Michael J. Burke
Jacques Dumas
Wenlang Fu
Barry Hart
Jeffrey Johnson
Gaetan H. Ladouceur
Andrea Mcclure
William J. Scott
Robert Sibley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of AU2002362603A1 publication Critical patent/AU2002362603A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2002362603A 2001-09-26 2002-09-26 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors Abandoned AU2002362603A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32499301P 2001-09-26 2001-09-26
US60/324,993 2001-09-26
PCT/US2002/030483 WO2003027085A2 (en) 2001-09-26 2002-09-26 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors

Publications (1)

Publication Number Publication Date
AU2002362603A1 true AU2002362603A1 (en) 2003-04-07

Family

ID=23265979

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002340010A Abandoned AU2002340010A1 (en) 2001-09-26 2002-09-26 Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors
AU2002362603A Abandoned AU2002362603A1 (en) 2001-09-26 2002-09-26 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2002340010A Abandoned AU2002340010A1 (en) 2001-09-26 2002-09-26 Substituted 3-pyridyl indoles and indazoles as c17,20 lyase inhibitors

Country Status (5)

Country Link
EP (2) EP1432706A2 (en)
JP (2) JP2005532983A (en)
AU (2) AU2002340010A1 (en)
CA (2) CA2461360A1 (en)
WO (8) WO2003027095A1 (en)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4160295B2 (en) * 2000-12-08 2008-10-01 武田薬品工業株式会社 Substituted thiazole derivatives having a 3-pyridyl group, method for producing the same, and use thereof
AU2002221080A1 (en) * 2000-12-08 2002-06-18 Masami Kusaka Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparingthe same and use thereof
US20040147561A1 (en) * 2002-12-27 2004-07-29 Wenge Zhong Pyrid-2-one derivatives and methods of use
WO2004110350A2 (en) * 2003-05-14 2004-12-23 Torreypines Therapeutics, Inc. Compouds and uses thereof in modulating amyloid beta
ES2222827B1 (en) * 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. DERIVATIVES OF 5-INDOLILSULFONAMIDS, ITS PREPARATION AND ITS APPLICATION AS MEDICINES.
CA2545719A1 (en) * 2003-11-14 2005-06-02 Vertex Pharmaceuticals Incorporated Thiazoles and oxazoles useful as modulators of atp-binding cassette transporters
AU2005232745A1 (en) * 2004-04-13 2005-10-27 Astellas Pharma Inc. Polycyclic pyrimidines as potassium ion channel modulators
JP4602686B2 (en) * 2004-04-15 2010-12-22 広栄化学工業株式会社 Process for producing 2,6-dihalogeno-4-arylpyridines
EP2402323A3 (en) 2004-10-13 2012-05-30 PTC Therapeutics, Inc. Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases
AR051248A1 (en) * 2004-10-20 2007-01-03 Applied Research Systems DERIVATIVES OF 3-ARILAMINO PIRIDINA
WO2006051723A1 (en) * 2004-11-09 2006-05-18 Kaneka Corporation Method for producing 1-halo-3-aryl-2-propanone
GB0428514D0 (en) * 2004-12-31 2005-02-09 Prosidion Ltd Compounds
AU2005325497A1 (en) * 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
KR20080019213A (en) 2005-05-09 2008-03-03 아칠리온 파르마세우티칼스 인코포레이티드 Thiazole compound and its use method
UA97348C2 (en) * 2005-07-29 2012-02-10 4Сц Аг HETEROCYCLIC NF-kB INHIBITORS
FR2889526B1 (en) 2005-08-04 2012-02-17 Aventis Pharma Sa SUBSTITUTED 7-AZA-INDAZOLES, COMPOSITIONS CONTAINING SAME, PROCESS FOR PRODUCTION AND USE
EP1932833B1 (en) * 2005-10-07 2012-08-01 Kissei Pharmaceutical Co., Ltd. Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
TWI385169B (en) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd Heterocyclic substituted pyridine derivatives and antifungal agent containing same
JP2009523701A (en) * 2005-12-28 2009-06-25 武田薬品工業株式会社 Fused heterocyclic compounds and uses thereof
CA2636826C (en) * 2006-01-18 2011-11-29 F.Hoffmann-La Roche Ag Thiazoles as 11 beta-hsd1 inhibitors
EP1979314B1 (en) * 2006-01-24 2013-01-09 Eli Lilly & Company Indole sulfonamide modulators of progesterone receptors
JP5249919B2 (en) * 2006-03-29 2013-07-31 エフ．ホフマン−ラ ロシュ アーゲー Pyridine and pyrimidine derivatives as mGluR2 antagonists
WO2008021338A2 (en) 2006-08-15 2008-02-21 Wyeth Tricyclic oxazolidone derivatives useful as pr modulators
WO2008021337A1 (en) 2006-08-15 2008-02-21 Wyeth Oxazinan-2-one derivatives useful as pr modulators
US7649007B2 (en) 2006-08-15 2010-01-19 Wyeth Llc Oxazolidine derivatives as PR modulators
US7652018B2 (en) 2006-08-15 2010-01-26 Wyeth Llc Imidazolidin-2-one derivatives useful as PR modulators
ATE534642T1 (en) * 2006-09-21 2011-12-15 Eisai R&D Man Co Ltd PYRIDINE DERIVATIVE SUBSTITUTED BY A HETEROARYL RING AND ANTIFUNGAL AGENT CONTAINING SAME
US8183264B2 (en) 2006-09-21 2012-05-22 Eisai R&D Managment Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
JP2010505866A (en) 2006-10-02 2010-02-25 コルテンド・インヴェスト・アクチボラゲット Ketoconazole enantiomers in humans
US8466154B2 (en) 2006-10-27 2013-06-18 The Board Of Regents Of The University Of Texas System Methods and compositions related to wrapping of dehydrons
US9187485B2 (en) 2007-02-02 2015-11-17 Baylor College Of Medicine Methods and compositions for the treatment of cancer and related hyperproliferative disorders
MX2009012613A (en) 2007-05-22 2010-04-21 Achillion Pharmaceuticals Inc Heteroaryl substituted thiazoles and their use as antiviral agents.
KR101597665B1 (en) 2007-08-13 2016-02-24 몬산토 테크놀로지 엘엘씨 Compositions and methods for controlling nematodes
JP5567481B2 (en) 2007-10-09 2014-08-06 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyridine derivatives useful as glucokinase activators
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
JP5584138B2 (en) * 2008-01-11 2014-09-03 ノバルティス アーゲー Pyrimidines as kinase inhibitors
US9029411B2 (en) 2008-01-25 2015-05-12 Millennium Pharmaceuticals, Inc. Thiophenes and uses thereof
US8563552B2 (en) 2008-02-08 2013-10-22 Shiseido Company Ltd. Whitening agent and skin external preparation
HUE060249T2 (en) * 2008-06-16 2023-02-28 Univ Tennessee Res Found Compounds for treatment of cancer
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
US8697694B2 (en) * 2008-08-20 2014-04-15 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
US8536185B2 (en) 2008-09-22 2013-09-17 Cayman Chemical Company, Incorporated Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases
US9139589B2 (en) 2009-01-30 2015-09-22 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
US20120010241A1 (en) * 2009-03-19 2012-01-12 Sanofi Hsp90 inhibiting indazole derivatives, compositions containing same and use thereof
ES2759949T3 (en) * 2009-10-29 2020-05-12 Bristol Myers Squibb Co Tricyclic Heterocyclic Compounds
WO2011051198A2 (en) * 2009-10-30 2011-05-05 Bayer Cropscience Ag Pyridine derivatives as agricultural pesticides
DE102009058280A1 (en) * 2009-12-14 2011-06-16 Merck Patent Gmbh thiazole
AU2010347233B2 (en) 2010-03-01 2015-06-18 Oncternal Therapeutics, Inc. Compounds for treatment of cancer
EP2593453B1 (en) 2010-07-15 2014-09-17 Bristol-Myers Squibb Company Azaindazole compounds
KR101823275B1 (en) 2010-08-04 2018-03-08 펠피큐어 파마슈티걸즈 아이엔씨 Combination therapy for the treatment of prostate carcinoma
JP2013533318A (en) 2010-08-11 2013-08-22 ミレニアム ファーマシューティカルズ， インコーポレイテッド Heteroaryl and uses thereof
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
MA34797B1 (en) 2010-08-11 2014-01-02 Millennium Pharm Inc HETEROARYLES AND THEIR USES
PH12013500723A1 (en) 2010-10-13 2017-08-23 Millennium Pharm Inc Heteroaryls and uses thereof
JP5953308B2 (en) * 2010-10-22 2016-07-20 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ New heterocyclic compounds as pesticides
AU2011320565A1 (en) * 2010-10-28 2013-05-23 Innocrin Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
EP2638041B1 (en) 2010-11-12 2015-07-22 Bristol-Myers Squibb Company Substituted azaindazole compounds
GB2485404A (en) * 2010-11-15 2012-05-16 Nat Univ Ireland Metal-complexed pyridyl-substituted tetrazole compounds and their use in treating cancer
CN102675286B (en) * 2011-03-07 2015-08-19 中国科学院上海药物研究所 Indazole compounds, preparation method, application and pharmaceutical composition thereof
EA023064B1 (en) 2011-04-28 2016-04-29 Новартис Аг 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
WO2012162468A1 (en) * 2011-05-25 2012-11-29 Janssen Pharmaceutica Nv Thiazol derivatives as pro -matrix metalloproteinase inhibitors
EP2760870B1 (en) 2011-09-27 2016-05-04 Bristol-Myers Squibb Company Substituted bicyclic heteroaryl compounds
WO2014055595A1 (en) 2012-10-05 2014-04-10 Merck Sharp & Dohme Corp. Indoline compounds as aldosterone synthase inhibitiors related applications
EP2934144B1 (en) * 2012-12-20 2017-07-19 Merck Sharp & Dohme Corp. Indazole compounds as aldosterone synthase inhibitors
CA2904338C (en) 2013-03-05 2022-07-05 University Of Tennessee Research Foundation Use of imidazole derivatives in combination with a braf inhibitor or mek inhibitor in the treatment of cancer
US20160022606A1 (en) 2013-03-14 2016-01-28 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
EP3191087A1 (en) 2014-09-12 2017-07-19 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
EP3528799A1 (en) 2016-10-24 2019-08-28 Pellficure Pharmaceuticals, Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione
JP7193071B2 (en) * 2017-02-08 2022-12-20 国立大学法人東海国立大学機構 Fluorescent materials and UV absorbers
WO2021126779A1 (en) * 2019-12-18 2021-06-24 The Regents Of The University Of California Inhibitors of lin28 and methods of use thereof
US20210246109A1 (en) * 2020-02-11 2021-08-12 University Of Kentucky Research Foundation Potent and selective inhibitors of cytochrome p450
WO2023049199A1 (en) * 2021-09-24 2023-03-30 Zeno Management, Inc. Azole compounds
CN117551029A (en) * 2023-11-22 2024-02-13 河南大学 A kind of synthetic method of 4-bromo-3-cyanopyridine

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK150068C (en) * 1978-06-02 1987-06-29 Pfizer METHOD OF ANALOGUE FOR THE PREPARATION OF AMINOTHIAZOLES
JPS55133366A (en) * 1979-04-05 1980-10-17 Otsuka Pharmaceut Factory Inc Thiazole derivative
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
DE3940476A1 (en) * 1989-12-07 1991-06-13 Bayer Ag PYRIDINYLPYRIMIDINE DERIVATIVES
DE3940477A1 (en) * 1989-12-07 1991-06-13 Bayer Ag HETARYL-SUBSTITUTED PYRIDINYLPYRIMIDINE DERIVATIVES
JPH04154773A (en) * 1990-10-15 1992-05-27 Green Cross Corp:The Thiazole derivative
DE4117560A1 (en) * 1991-05-29 1992-12-03 Bayer Ag USE OF PYRIDINYLPYRIMIDINE DERIVATIVES TO PROTECT TECHNICAL MATERIALS
TW223004B (en) * 1991-11-25 1994-05-01 Sumitomo Chemical Co
US5599774A (en) * 1992-01-22 1997-02-04 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5395817A (en) * 1992-01-22 1995-03-07 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5444038A (en) * 1992-03-09 1995-08-22 Zeneca Limited Arylindazoles and their use as herbicides
DE69328964T2 (en) * 1992-03-09 2000-11-09 Zeneca Ltd., London ARYLINDAZOLINE AND THEIR USE AS HERBICIDES
KR980700077A (en) * 1994-11-29 1998-03-30 나까토미 히로타카 Antibacterial Prepartion or Bactericide comprising 2-Aminothiazole Derivative or Salt Thereof
US6046136A (en) * 1997-06-24 2000-04-04 Zeneca Limited Herbicidal heterocyclic N-oxides compounds
US5840721A (en) * 1997-07-09 1998-11-24 Ontogen Corporation Imidazole derivatives as MDR modulators
AU732406B2 (en) * 1997-10-03 2001-04-26 Merck Frosst Canada & Co. Aryl thiophene derivatives as PDE IV inhibitors
EP1077958A1 (en) * 1998-05-12 2001-02-28 American Home Products Corporation Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
AU5227999A (en) * 1998-07-27 2000-02-21 Abbott Laboratories Substituted oxazolines as antiproliferative agents
EP1261607B1 (en) * 2000-03-01 2008-11-12 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives

Also Published As

Publication number Publication date
WO2003027094A3 (en) 2003-10-23
WO2003027101A1 (en) 2003-04-03
WO2003027105A1 (en) 2003-04-03
EP1432698A2 (en) 2004-06-30
CA2461360A1 (en) 2003-04-03
WO2003027085A3 (en) 2003-12-04
CA2461363A1 (en) 2003-04-03
WO2003027107A1 (en) 2003-04-03
JP2005532983A (en) 2005-11-04
WO2003027085A2 (en) 2003-04-03
WO2003027094A2 (en) 2003-04-03
AU2002340010A1 (en) 2003-04-07
WO2003027095A1 (en) 2003-04-03
WO2003027100A1 (en) 2003-04-03
EP1432706A2 (en) 2004-06-30
WO2003027096A1 (en) 2003-04-03
JP2005528325A (en) 2005-09-22

Similar Documents

Publication Publication Date Title
AU2002362603A1 (en) 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors
AU2002224927A1 (en) Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds
AU2001251063A1 (en) 3-cyanoquinolines,3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors
AU2001262723A1 (en) 1,2-dihydropyridine compounds, process for preparation of the same and use thereof
MXPA03009097A (en) Benzamidine derivative.
AU2002346628A1 (en) Method for improving dispatch response time
AU2002221753A1 (en) Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
AU5248800A (en) Fading inhibitors
AU2003288023A1 (en) Process for the manufacture of 1,2-epoxy-3-chloropropane
AU2002356180A1 (en) Methods for inhibiting angiogenesis
AU2002358179A1 (en) New rennets
AU2002365372A1 (en) New process
AU2002348998A1 (en) N-methyl-homocystines, use thereof and method for the production thereof
AU2002327756A1 (en) Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors
AU2002334729A1 (en) Substituted 3-pyridyl thiophenes as c17,20 lyase inhibitors
AU2002337751A1 (en) Substituted 3-pyridyl pyrimidines as c17,20 lyase inhibitors
AU2002334730A1 (en) Substituted 3-pyridyl imidazoles as c17,20 lyase inhibitors
AU2002337761A1 (en) Substituted 3-pyridyl tetrazoles as steroid c17,20 lyase inhibitors
AU2002213830A1 (en) The use of selective noradrenaline reuptake inhibitors for the treatment of tension-type headache
AU2003208275A1 (en) Trojan inhibitors, method for the production and use thereof
AU6730001A (en) Component, method for production and use thereof
AU2002216911A1 (en) Method for the production of 4-(17alpha substituted 3-oxoestra-4,9-dien-11beta-yl)benzaldehyd-(1E or 1Z)-oximes
AU2002352606A1 (en) Eurotinone and derivatives thereof, method for the production and use of the same
AU2003216893A1 (en) Phenethylacrylamide, methods for the production thereof and agents containing the same
AU2002334728A1 (en) Substituted 3-pyridyl pyrroles and 3-pyridyl pyrazoles as c17,20 lyase inhibitors

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase