AU2002221753A1 - Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same - Google Patents

Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

Info

Publication number: AU2002221753A1
Authority: AU; Australia
Prior art keywords: azaindoles; phosphodiesterase; inhibitors; novel; producing
Prior art date: 2000-10-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

AU2002221753A

Other versions

AU2002221753B2 (en

Inventor

Ute Egerland

Norbert Hofgen

Thomas Kronbach

Hildegard Kuss

Degenhard Marx

Emmanuel Polymeropoulos

Stefan Szelenyi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Biotie Therapies GmbH

Original Assignee

Biotie Therapies GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-27

Filing date

2001-10-25

Publication date

2002-07-11

2000-10-27 Priority claimed from DE10053275A external-priority patent/DE10053275A1/en

2001-10-25 Application filed by Biotie Therapies GmbH filed Critical Biotie Therapies GmbH

2001-10-25 Priority claimed from PCT/EP2001/012376 external-priority patent/WO2002034747A1/en

2002-07-11 Publication of AU2002221753A1 publication Critical patent/AU2002221753A1/en

2006-12-14 Application granted granted Critical

2006-12-14 Publication of AU2002221753B2 publication Critical patent/AU2002221753B2/en

2011-01-20 Assigned to BIOTIE THERAPIES GMBH reassignment BIOTIE THERAPIES GMBH Request to Amend Deed and Register Assignors: ELBION AG

2021-10-25 Anticipated expiration legal-status Critical

Status Ceased legal-status Critical Current

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE10053275A DE10053275A1 (en)	2000-10-27	2000-10-27	New 7-aza-indole-3-carboxamides or glyoxylamides, useful e.g. for treating rheumatoid arthritis, osteoporosis, sepsis, asthma or multiple sclerosis are phosphodiesterase-4 and tumor necrosis factor-alpha inhibitors
DE10053275.6		2000-10-27
US24434200P	2000-10-30	2000-10-30
US60/244,342		2000-10-30
PCT/EP2001/012376 WO2002034747A1 (en)	2000-10-27	2001-10-25	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

Publications (2)

Publication Number	Publication Date
AU2002221753A1 true AU2002221753A1 (en)	2002-07-11
AU2002221753B2 AU2002221753B2 (en)	2006-12-14

Family

ID=26007507

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AU2175302A Pending AU2175302A (en)	2000-10-27	2001-10-25	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method forproducing the same
AU2002221753A Ceased AU2002221753B2 (en)	2000-10-27	2001-10-25	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AU2175302A Pending AU2175302A (en)	2000-10-27	2001-10-25	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method forproducing the same

Country Status (27)

Country	Link
US (3)	US7169787B2 (en)
EP (1)	EP1330455B1 (en)
JP (1)	JP4233322B2 (en)
KR (2)	KR100880586B1 (en)
CN (1)	CN1247576C (en)
AR (1)	AR034269A1 (en)
AT (1)	ATE301121T1 (en)
AU (2)	AU2175302A (en)
BG (1)	BG66169B1 (en)
BR (1)	BR0114903A (en)
CA (1)	CA2428468C (en)
CZ (1)	CZ20031146A3 (en)
DE (1)	DE50106993D1 (en)
DK (1)	DK1330455T3 (en)
EE (1)	EE05271B1 (en)
ES (1)	ES2246349T3 (en)
HR (1)	HRP20030427B1 (en)
HU (1)	HUP0303034A3 (en)
IL (2)	IL155386A0 (en)
MX (1)	MXPA03003624A (en)
NO (1)	NO324947B1 (en)
NZ (1)	NZ525369A (en)
PL (1)	PL213999B1 (en)
PT (1)	PT1330455E (en)
SK (1)	SK287774B6 (en)
TW (1)	TWI262920B (en)
WO (1)	WO2002034747A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040014761A1 (en) *	1997-10-28	2004-01-22	Place Virgil A.	Treatment of female sexual dysfunction with phosphodiesterase inhibitors
CA2505131A1 (en) *	2002-11-06	2004-05-27	Celgene Corporation	Methods and compositions using selective cytokine inhibitory drugs for treatment and management of cancers and other diseases
DE10318610A1 (en) *	2003-04-24	2004-11-11	Elbion Ag	7-azaindoles and their use as therapeutic agents
US20050054691A1 (en) *	2003-08-29	2005-03-10	St. Jude Children's Research Hospital	Carboxylesterase inhibitors
CN102060806A (en) *	2003-09-11	2011-05-18	iTherX药品公司	Cytokine inhibitors
EP1742627A4 (en)	2004-05-06	2009-08-26	Plexxikon Inc	Pde4b inhibitors and uses therefor
MY144903A (en)	2004-06-17	2011-11-30	Novartis Ag	Pyrrolopyridine derivatives and their use as crth2 antagonists
CA2583428A1 (en) *	2004-09-03	2006-03-09	Plexxikon, Inc.	Bicyclic heteroaryl pde4b inhibitors
JP2009514969A (en)	2005-11-09	2009-04-09	コンビナトアールエックスインコーポレーティッド	Methods, compositions, and kits for treating medical conditions
GB0525143D0 (en)	2005-12-09	2006-01-18	Novartis Ag	Organic compounds
CA2651732C (en)	2006-05-18	2014-10-14	Mannkind Corporation	Intracellular kinase inhibitors
US20100056791A1 (en) *	2006-09-01	2010-03-04	Yasushi Kohno	Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same
US8012992B2 (en)	2008-06-30	2011-09-06	Allergan, Inc.	Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
KR20110079669A (en) *	2008-09-22	2011-07-07	아이시스 이노베이션 리미티드	5-azaindole bisphosphonate
CA2771939A1 (en) *	2009-08-26	2011-03-03	Nycomed Gmbh	Methylpyrrolopyridinecarboxamides
WO2012072727A1 (en) *	2010-12-03	2012-06-07	Biotie Therapies Gmbh	Crystalline modification of n-(3,5-dichloropyridin-4-yl)-[1-(4 -fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide as inhibitor of pde4
WO2012080329A1 (en)	2010-12-17	2012-06-21	Biotie Therapies Gmbh	Formulations of n-(3,5-dichloropyridin-4-yl)-[1-(4-fluorobenzyl)-7-azaindol-3-yl)]glyoxylic acid amide
CN102584842A (en) *	2011-01-17	2012-07-18	北京大学	Preparation of substituted indole lactam derivative and application of substituted indole lactam derivative as antimalarial agent
DK2888010T3 (en)	2012-08-22	2021-06-28	Univ Cornell	PROCEDURES TO INHIBIT FASCIN
DK3107902T3 (en) *	2014-02-20	2021-05-03	Cornell Univ Cornell Center For Technology Enterprise & Commercialization Cctec	CONNECTIONS AND METHODS OF INHIBITING FASCIN
EP3863638B1 (en) *	2018-10-12	2024-06-26	Board of Regents of the University of Nebraska	Phosphodiesterase inhibitors
WO2020180876A1 (en)	2019-03-04	2020-09-10	Beth Israel Deaconess Medical Center, Inc.	Orai channel inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1141949A (en) *	1966-02-23	1969-02-05	Sterling Drug Inc	7-azaindole derivatives
WO1991009598A1 (en)	1990-01-05	1991-07-11	Pfizer Inc.	Azaoxindole derivatives
US5023265A (en)	1990-06-01	1991-06-11	Schering Corporation	Substituted 1-H-pyrrolopyridine-3-carboxamides
US5811432A (en)	1990-11-09	1998-09-22	Pfizer Inc	Azaoxindole derivatives
IL106517A0 (en)	1992-07-28	1994-08-26	Rhone Poulenc Rorer Ltd	Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic or heteroatom containing linking group
JPH08503450A (en)	1992-08-06	1996-04-16	ワーナー−ランバート・コンパニー	2-Thioindole (selenoindole) and related disulfides (selenides) that inhibit protein tyrosine kinases and have antitumor properties
JP3119758B2 (en) *	1993-02-24	2000-12-25	日清製粉株式会社	7-Azaindole derivative and antiulcer drug containing the same as active ingredient
ATE255413T1 (en)	1994-04-21	2003-12-15	Schering Ag	PDE IV INHIBITORS FOR THE TREATMENT OF MULTIPLE SCLERosis
GB9420521D0 (en) *	1994-10-12	1994-11-30	Smithkline Beecham Plc	Novel compounds
GB9507297D0 (en)	1995-04-07	1995-05-31	Rh Ne Poulenc Rorer Limited	New composition of matter
JPH09169665A (en)	1995-12-21	1997-06-30	Kenichi Miyamoto	Agent for treatment osteoporosis
JP3601898B2 (en)	1996-02-14	2004-12-15	俊隆鍋島	Drug-dependent formation inhibitor
AUPO282996A0 (en) *	1996-10-07	1996-10-31	Fujisawa Pharmaceutical Co., Ltd.	Novel compounds
AU3868500A (en) *	1999-03-10	2000-09-28	Merck & Co., Inc.	6-azaindole compounds as antagonists of gonadotropin releasing hormone

2001
- 2001-10-24 TW TW090126313A patent/TWI262920B/en not_active IP Right Cessation
- 2001-10-25 US US10/399,051 patent/US7169787B2/en not_active Expired - Fee Related
- 2001-10-25 KR KR1020087003517A patent/KR100880586B1/en not_active Expired - Fee Related
- 2001-10-25 BR BR0114903-2A patent/BR0114903A/en not_active IP Right Cessation
- 2001-10-25 CA CA2428468A patent/CA2428468C/en not_active Expired - Fee Related
- 2001-10-25 KR KR1020037005801A patent/KR100837099B1/en not_active Expired - Fee Related
- 2001-10-25 HU HU0303034A patent/HUP0303034A3/en unknown
- 2001-10-25 DE DE50106993T patent/DE50106993D1/en not_active Expired - Lifetime
- 2001-10-25 DK DK01988718T patent/DK1330455T3/en active
- 2001-10-25 MX MXPA03003624A patent/MXPA03003624A/en active IP Right Grant
- 2001-10-25 ES ES01988718T patent/ES2246349T3/en not_active Expired - Lifetime
- 2001-10-25 PT PT01988718T patent/PT1330455E/en unknown
- 2001-10-25 EP EP01988718A patent/EP1330455B1/en not_active Expired - Lifetime
- 2001-10-25 AU AU2175302A patent/AU2175302A/en active Pending
- 2001-10-25 AU AU2002221753A patent/AU2002221753B2/en not_active Ceased
- 2001-10-25 NZ NZ525369A patent/NZ525369A/en not_active IP Right Cessation
- 2001-10-25 HR HR20030427A patent/HRP20030427B1/en not_active IP Right Cessation
- 2001-10-25 IL IL15538601A patent/IL155386A0/en active IP Right Grant
- 2001-10-25 CN CNB018215351A patent/CN1247576C/en not_active Expired - Fee Related
- 2001-10-25 EE EEP200300166A patent/EE05271B1/en not_active IP Right Cessation
- 2001-10-25 AT AT01988718T patent/ATE301121T1/en active
- 2001-10-25 JP JP2002537738A patent/JP4233322B2/en not_active Expired - Fee Related
- 2001-10-25 CZ CZ20031146A patent/CZ20031146A3/en unknown
- 2001-10-25 WO PCT/EP2001/012376 patent/WO2002034747A1/en not_active Ceased
- 2001-10-25 SK SK509-2003A patent/SK287774B6/en not_active IP Right Cessation
- 2001-10-25 PL PL362837A patent/PL213999B1/en not_active IP Right Cessation
- 2001-10-26 AR ARP010105014A patent/AR034269A1/en active IP Right Grant
2003
- 2003-04-10 IL IL155386A patent/IL155386A/en not_active IP Right Cessation
- 2003-04-14 NO NO20031722A patent/NO324947B1/en not_active IP Right Cessation
- 2003-04-16 BG BG107725A patent/BG66169B1/en unknown
2006
- 2006-01-10 US US11/329,400 patent/US7419987B2/en not_active Expired - Fee Related
2008
- 2008-03-10 US US12/075,312 patent/US7683074B2/en not_active Expired - Fee Related

Similar Documents

Publication	Publication Date	Title
AU2002221753A1 (en)	2002-07-11	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
IL155386A0 (en)	2003-11-23	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
AU2002222293A1 (en)	2002-07-01	Pyrazolo(3,4-c)pyridines as gsk-3 inhibitors
TWI315741B (en)	2009-10-11	A-isomaltosyltransferase, process for producing the same and use thereof
AU2002224927A1 (en)	2002-06-24	Use of substituted imidazoazines, novel imidazoazines, methods for the production thereof, and agents containing these compounds
AU2002349477A1 (en)	2003-06-10	Bicyclic derivative, process for producing the same, and use
PL392790A1 (en)	2011-01-03	Pyrazole [3, 4-b] pyridine compounds and the use thereof as phosphodiesterase inhibitors
PL357522A1 (en)	2004-07-26	5-(2-substituted-5-heterocyclylsulphonylpyrid-3-yl)-dihydropyrazolo[4,3-d]pyrimidin-7-ones as phosphodiesterase inhibitors
AU2002337047A1 (en)	2003-06-05	Novel dihydropteridinones, method for producing the same and the use thereof as medicaments
AU2002227985A1 (en)	2002-06-24	Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
AU2001276295A1 (en)	2002-03-13	Electric component, method for the production thereof, and its use
AU2001294228A1 (en)	2002-04-22	Benzimidazole compounds, process for producing the same and use thereof
AU2003271185A1 (en)	2004-05-04	Imidazopyridine derivative, process for producing the same, and use
AU5652698A (en)	1998-06-03	(2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors
AU2001272329A1 (en)	2001-12-17	Ultrahydrophobic surfaces, methods for the production thereof and their use
AU2003289176A1 (en)	2004-07-29	1,3-benzothiazinone derivatives, process for producing the same and use thereof
AU2002227966A1 (en)	2002-08-22	Coniosetin and derivatives thereof, method for producing the same and use thereof
AU2001286188A1 (en)	2002-03-26	Tricyclic heterocyclic compound, process for producing the same, and use thereof
AU2796602A (en)	2002-06-18	Coniosetin and derivatives thereof, method for producing the same and use thereof
ZA200303236B (en)	2003-07-31	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same.
AU2001252254A1 (en)	2001-11-12	2,6-diamino-6-methyl-heptanoic acid and derivatives, process for the preparationthereof and use thereof
AU2002348998A1 (en)	2003-07-24	N-methyl-homocystines, use thereof and method for the production thereof
SI1330455T1 (en)	2005-12-31	Novel 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
AU2001285905A1 (en)	2002-03-13	6,7-dihydro-pyrrolo(3,4-b)pyridin-5-ones with an anticonvulsive action and methods for producing the same
AU2002227952A1 (en)	2002-08-22	Klainetin and derivatives thereof, method for their production and the use of the same