AU2002229141A1 - Hydrogel-driven drug dosage form - Google Patents

Hydrogel-driven drug dosage form

Info

Publication number: AU2002229141A1
Authority: AU; Australia
Prior art keywords: drug; water; dosage form; containing composition; core
Prior art date: 2000-08-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2002229141A

Other languages

English (en)

Inventor

Leah Elizabeth Appel

Walter C. Babcock

Ronald Arthur Beyerinck

Mark Brian Chidlaw

William John Curatolo

Dwayne Thomas Friesen

Scott Max Herbig

Avinash Govind Thombre

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Products Inc

Original Assignee

Pfizer Products Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-09

Filing date

2001-08-03

Publication date

2002-02-18

2001-08-03 Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc

2002-02-18 Publication of AU2002229141A1 publication Critical patent/AU2002229141A1/en

Status Abandoned legal-status Critical Current

Links

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239000011248 coating agent Substances 0.000 claims description 189
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235000011152 sodium sulphate Nutrition 0.000 description 1
235000010265 sodium sulphite Nutrition 0.000 description 1
HRQDCDQDOPSGBR-UHFFFAOYSA-M sodium;octane-1-sulfonate Chemical compound [Na+].CCCCCCCCS([O-])(=O)=O HRQDCDQDOPSGBR-UHFFFAOYSA-M 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
229960002920 sorbitol Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
229960001294 spiramycin Drugs 0.000 description 1
235000019372 spiramycin Nutrition 0.000 description 1
229930191512 spiramycin Natural products 0.000 description 1
LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
229960002256 spironolactone Drugs 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
230000003637 steroidlike Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
229960004940 sulpiride Drugs 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
230000002522 swelling effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229960000580 terconazole Drugs 0.000 description 1
IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
RBTVSNLYYIMMKS-UHFFFAOYSA-N tert-butyl 3-aminoazetidine-1-carboxylate;hydrochloride Chemical compound Cl.CC(C)(C)OC(=O)N1CC(N)C1 RBTVSNLYYIMMKS-UHFFFAOYSA-N 0.000 description 1
239000012085 test solution Substances 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
229940072172 tetracycline antibiotic Drugs 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
239000004308 thiabendazole Substances 0.000 description 1
235000010296 thiabendazole Nutrition 0.000 description 1
229960004546 thiabendazole Drugs 0.000 description 1
WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
229960000882 thiothixene hydrochloride Drugs 0.000 description 1
229960004605 timolol Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
229960003386 triazolam Drugs 0.000 description 1
229960002906 trimazosin Drugs 0.000 description 1
YNZXWQJZEDLQEG-UHFFFAOYSA-N trimazosin Chemical compound N1=C2C(OC)=C(OC)C(OC)=CC2=C(N)N=C1N1CCN(C(=O)OCC(C)(C)O)CC1 YNZXWQJZEDLQEG-UHFFFAOYSA-N 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
229960005041 troleandomycin Drugs 0.000 description 1
LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
229940124549 vasodilator Drugs 0.000 description 1
239000003071 vasodilator agent Substances 0.000 description 1
PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
229960004688 venlafaxine Drugs 0.000 description 1
229920006163 vinyl copolymer Polymers 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
229940100050 virazole Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 1
229960004740 voriconazole Drugs 0.000 description 1
239000003643 water by type Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
229960000607 ziprasidone Drugs 0.000 description 1
MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AU2002229141A 2000-08-09 2001-08-03 Hydrogel-driven drug dosage form Abandoned AU2002229141A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US22419900P	2000-08-09	2000-08-09
US60/224199		2000-08-09
PCT/IB2001/001390 WO2002011702A2 (en)	2000-08-09	2001-08-03	Hydrogel-driven drug dosage form

Publications (1)

Publication Number	Publication Date
AU2002229141A1 true AU2002229141A1 (en)	2002-02-18

Family

ID=22839665

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2002229141A Abandoned AU2002229141A1 (en)	2000-08-09	2001-08-03	Hydrogel-driven drug dosage form

Country Status (30)

Country	Link
US (2)	US20030086972A1 (es)
EP (1)	EP1326587A2 (es)
JP (1)	JP2004505907A (es)
KR (1)	KR20030024844A (es)
CN (1)	CN1461212A (es)
AP (1)	AP2001002237A0 (es)
AU (1)	AU2002229141A1 (es)
BG (1)	BG107538A (es)
BR (1)	BR0113067A (es)
CA (1)	CA2418907A1 (es)
DO (1)	DOP2001000229A (es)
EA (1)	EA200300081A1 (es)
EC (1)	ECSP034455A (es)
EE (1)	EE200300055A (es)
GT (1)	GT200100161A (es)
HR (1)	HRP20030082A2 (es)
HU (1)	HUP0300722A2 (es)
IL (1)	IL154012A0 (es)
IS (1)	IS6686A (es)
MA (1)	MA26939A1 (es)
MX (1)	MXPA03001209A (es)
NO (1)	NO20030627L (es)
OA (1)	OA12365A (es)
PA (1)	PA8524901A1 (es)
PE (1)	PE20020307A1 (es)
PL (1)	PL360658A1 (es)
SV (1)	SV2002000586A (es)
TN (1)	TNSN01123A1 (es)
UY (1)	UY26876A1 (es)
WO (1)	WO2002011702A2 (es)

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2001
- 2001-08-01 US US09/920,056 patent/US20030086972A1/en not_active Abandoned
- 2001-08-03 WO PCT/IB2001/001390 patent/WO2002011702A2/en not_active Ceased
- 2001-08-03 US US10/344,171 patent/US20040052845A1/en not_active Abandoned
- 2001-08-03 HR HR20030082A patent/HRP20030082A2/hr not_active Application Discontinuation
- 2001-08-03 JP JP2002517039A patent/JP2004505907A/ja active Pending
- 2001-08-03 KR KR10-2003-7001861A patent/KR20030024844A/ko not_active Ceased
- 2001-08-03 MX MXPA03001209A patent/MXPA03001209A/es not_active Application Discontinuation
- 2001-08-03 AP APAP/P/2001/002237A patent/AP2001002237A0/en unknown
- 2001-08-03 OA OA1200300043A patent/OA12365A/en unknown
- 2001-08-03 PL PL36065801A patent/PL360658A1/xx not_active Application Discontinuation
- 2001-08-03 EE EEP200300055A patent/EE200300055A/xx unknown
- 2001-08-03 CA CA002418907A patent/CA2418907A1/en not_active Abandoned
- 2001-08-03 IL IL15401201A patent/IL154012A0/xx unknown
- 2001-08-03 HU HU0300722A patent/HUP0300722A2/hu unknown
- 2001-08-03 AU AU2002229141A patent/AU2002229141A1/en not_active Abandoned
- 2001-08-03 CN CN01816024A patent/CN1461212A/zh active Pending
- 2001-08-03 EP EP01984471A patent/EP1326587A2/en not_active Withdrawn
- 2001-08-03 BR BR0113067-6A patent/BR0113067A/pt not_active IP Right Cessation
- 2001-08-03 EA EA200300081A patent/EA200300081A1/ru unknown
- 2001-08-08 SV SV2001000586A patent/SV2002000586A/es not_active Application Discontinuation
- 2001-08-08 UY UY26876A patent/UY26876A1/es not_active Application Discontinuation
- 2001-08-08 PE PE2001000791A patent/PE20020307A1/es not_active Application Discontinuation
- 2001-08-08 DO DO2001000229A patent/DOP2001000229A/es unknown
- 2001-08-08 GT GT200100161A patent/GT200100161A/es unknown
- 2001-08-08 TN TNTNSN01123A patent/TNSN01123A1/fr unknown
- 2001-08-09 PA PA20018524901A patent/PA8524901A1/es unknown
2003
- 2003-01-16 IS IS6686A patent/IS6686A/is unknown
- 2003-01-28 EC EC2003004455A patent/ECSP034455A/es unknown
- 2003-01-29 MA MA27017A patent/MA26939A1/fr unknown
- 2003-02-06 BG BG107538A patent/BG107538A/bg unknown
- 2003-02-07 NO NO20030627A patent/NO20030627L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA200300081A1 (ru)	2003-08-28
SV2002000586A (es)	2002-10-24
JP2004505907A (ja)	2004-02-26
MXPA03001209A (es)	2003-06-30
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US20030086972A1 (en)	2003-05-08
PE20020307A1 (es)	2002-04-23
DOP2001000229A (es)	2002-09-30
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US20040052845A1 (en)	2004-03-18
ECSP034455A (es)	2003-03-10
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OA12365A (en)	2006-05-16
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AP2001002237A0 (en)	2001-09-30
CN1461212A (zh)	2003-12-10

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NZ539915A (en)	2007-09-28	Controlled-release of an active substance into a high fat environment
WO2007057762A2 (en)	2007-05-24	Osmotic bi-layer tablet