AU2001237992A1 - Purification of oligonucleotides - Google Patents

Purification of oligonucleotides

Info

Publication number: AU2001237992A1
Authority: AU; Australia
Prior art keywords: oligonucleotides; purification
Prior art date: 2000-01-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001237992A

Inventor

Achim H. Krotz

Vasulinga T. Ravikumar

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ionis Pharmaceuticals Inc

Original Assignee

Isis Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-31

Filing date

2001-01-30

Publication date

2001-08-07

2001-01-30 Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc

2001-08-07 Publication of AU2001237992A1 publication Critical patent/AU2001237992A1/en

Status Abandoned legal-status Critical Current

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
238000000746 purification Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Saccharide Compounds (AREA)

AU2001237992A 2000-01-31 2001-01-30 Purification of oligonucleotides Abandoned AU2001237992A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US09/495,398 US6586586B1 (en)	2000-01-31	2000-01-31	Purification of oligonucleotides
US09495398		2000-01-31
PCT/US2001/002951 WO2001055160A1 (en)	2000-01-31	2001-01-30	Purification of oligonucleotides

Publications (1)

Publication Number	Publication Date
AU2001237992A1 true AU2001237992A1 (en)	2001-08-07

Family

ID=23968503

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001237992A Abandoned AU2001237992A1 (en)	2000-01-31	2001-01-30	Purification of oligonucleotides

Country Status (7)

Country	Link
US (2)	US6586586B1 (en)
EP (1)	EP1252173A4 (en)
JP (1)	JP2003531827A (en)
KR (1)	KR20030032915A (en)
AU (1)	AU2001237992A1 (en)
CA (1)	CA2398749A1 (en)
WO (1)	WO2001055160A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6899889B1 (en) *	1998-11-06	2005-05-31	Neomend, Inc.	Biocompatible material composition adaptable to diverse therapeutic indications
US7279001B2 (en) *	1998-11-06	2007-10-09	Neomend, Inc.	Systems, methods, and compositions for achieving closure of vascular puncture sites
US6830756B2 (en) *	1998-11-06	2004-12-14	Neomend, Inc.	Systems, methods, and compositions for achieving closure of vascular puncture sites
US7351249B2 (en) *	1998-11-06	2008-04-01	Neomend, Inc.	Systems, methods, and compositions for achieving closure of suture sites
AU2003292632A1 (en) *	2002-12-26	2004-07-22	Shionogi Co., Ltd.	Method of purifying/concentrating sugar chain with sugar chain-trapping molecule and method of analyzing sugar chain structure
US20050112625A1 (en) *	2003-08-22	2005-05-26	Konica Minolta Medical & Graphic, Inc.	DNA amplification method
CN100416389C (en) *	2004-11-29	2008-09-03	友达光电股份有限公司	Liquid crystal display device and manufacturing method thereof
UA88676C2 (en) *	2005-01-28	2009-11-10	Гириндус Аг	Process for the purification of protected oligonucleotides
KR100850430B1 (en) *	2006-12-11	2008-08-05	(주)바이오니아	Method for isolating a nucleic acid using particulate matter and a compositions therefor
GB201115218D0 (en)	2011-09-02	2011-10-19	Glaxo Group Ltd	Novel process
GB201612011D0 (en)	2016-07-11	2016-08-24	Glaxosmithkline Ip Dev Ltd	Novel processes for the production of oligonucleotides
GB201721307D0 (en)	2017-12-19	2018-01-31	Glaxosmithkline Ip Dev Ltd	Novel processes for the production of oligonucleotides
US20230095192A1 (en)	2020-03-03	2023-03-30	University Of Washington	Synthetic agonists of dna-pk and their use
EP4137500A4 (en) *	2020-04-14	2024-06-19	Sumitomo Chemical Company, Limited	METHOD FOR PRODUCING NUCLEIC ACID OLIGOMER
WO2021210409A1 (en) *	2020-04-14	2021-10-21	住友化学株式会社	Composition containing nucleic acid oligomer
US20250223620A1 (en)	2022-04-08	2025-07-10	Glaxosmithkline Intellectual Property Development Limited	Novel processes for the production of polynucleotides including oligonucleotides
US12168674B1 (en)	2023-12-08	2024-12-17	Oligo Foundry, Inc.	Reagents and methods for the highly-efficient synthesis and purification of biopolymers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3433649A1 (en) *	1984-09-13	1986-03-20	Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig	METHOD FOR PURIFYING SYNTHETIC OLIGONUCLEOTIDES
US4947927A (en) *	1989-11-08	1990-08-14	Pcc Airfoils, Inc.	Method of casting a reactive metal against a surface formed from an improved slurry containing yttria
WO1992007951A1 (en)	1990-10-19	1992-05-14	Yoke Wah Kow	Quantitation of aldehyde-containing lesions in nucleic acids

2000
- 2000-01-31 US US09/495,398 patent/US6586586B1/en not_active Expired - Lifetime
2001
- 2001-01-30 WO PCT/US2001/002951 patent/WO2001055160A1/en not_active Ceased
- 2001-01-30 KR KR1020027009889A patent/KR20030032915A/en not_active Withdrawn
- 2001-01-30 EP EP01910379A patent/EP1252173A4/en not_active Withdrawn
- 2001-01-30 AU AU2001237992A patent/AU2001237992A1/en not_active Abandoned
- 2001-01-30 JP JP2001561018A patent/JP2003531827A/en active Pending
- 2001-01-30 CA CA002398749A patent/CA2398749A1/en not_active Abandoned
2003
- 2003-01-02 US US10/337,004 patent/US20030153742A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA2398749A1 (en)	2001-08-02
US6586586B1 (en)	2003-07-01
WO2001055160A1 (en)	2001-08-02
US20030153742A1 (en)	2003-08-14
EP1252173A4 (en)	2003-02-12
JP2003531827A (en)	2003-10-28
EP1252173A1 (en)	2002-10-30
KR20030032915A (en)	2003-04-26

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AU2001285009A1 (en)	2002-04-08	Water purification system
AU2001237992A1 (en)	2001-08-07	Purification of oligonucleotides
AU2001259501A1 (en)	2001-11-20	Continuous liquid purification process
AU2001281275A1 (en)	2002-02-25	Processes for the preparation of oligonucleotides
AU2001274571A1 (en)	2002-03-21	Micro-array of organism-associated substance
AU2001266225A1 (en)	2002-01-21	Decondensation of dna
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AU2001251115A1 (en)	2001-10-15	Use of locally applied dna fragments
AU2002245107A1 (en)	2002-07-30	Improved biochip
AU2002310296A1 (en)	2002-12-16	Rna purification methods
AU2002214868A1 (en)	2002-05-15	Therapeutic oligonucleotides of reduced toxicity
EP1238585B8 (en)	2005-07-06	Use of esterquats
AU2001271444A1 (en)	2002-01-08	Purification means
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AU2001264931A1 (en)	2001-12-03	High-throughput purification process
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AU2001258330A1 (en)	2001-10-30	New uses of imidazolylmethyl-pyridines
AU2002236439A1 (en)	2002-05-27	Purification of argon
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