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AU2001281275A1 - Processes for the preparation of oligonucleotides - Google Patents

Processes for the preparation of oligonucleotides

Info

Publication number
AU2001281275A1
AU2001281275A1 AU2001281275A AU8127501A AU2001281275A1 AU 2001281275 A1 AU2001281275 A1 AU 2001281275A1 AU 2001281275 A AU2001281275 A AU 2001281275A AU 8127501 A AU8127501 A AU 8127501A AU 2001281275 A1 AU2001281275 A1 AU 2001281275A1
Authority
AU
Australia
Prior art keywords
oligonucleotides
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001281275A
Inventor
Yogesh S Sanghvi
Quanlai Song
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of AU2001281275A1 publication Critical patent/AU2001281275A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
AU2001281275A 2000-08-16 2001-08-16 Processes for the preparation of oligonucleotides Abandoned AU2001281275A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09640279 2000-08-16
US09/640,279 US6809195B1 (en) 2000-08-16 2000-08-16 Process for the preparation of oligonucleotides
PCT/US2001/025623 WO2002014340A1 (en) 2000-08-16 2001-08-16 Processes for the preparation of oligonucleotides_______________

Publications (1)

Publication Number Publication Date
AU2001281275A1 true AU2001281275A1 (en) 2002-02-25

Family

ID=24567595

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001281275A Abandoned AU2001281275A1 (en) 2000-08-16 2001-08-16 Processes for the preparation of oligonucleotides

Country Status (4)

Country Link
US (2) US6809195B1 (en)
EP (1) EP1311526A1 (en)
AU (1) AU2001281275A1 (en)
WO (1) WO2002014340A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6809195B1 (en) * 2000-08-16 2004-10-26 Isis Pharmaceuticals, Inc. Process for the preparation of oligonucleotides
US7906633B2 (en) * 2003-02-20 2011-03-15 Eisai R&D Management Co., Ltd. Reagents and methods for preparing LPS antagonist B1287 and stereoisomers thereof
WO2007128463A1 (en) * 2006-05-02 2007-11-15 Dsm Ip Assets B.V. Process for the deprotection of protected amines
KR20100111305A (en) * 2008-02-08 2010-10-14 프로센사 홀딩 비브이 Sulfurization agent and its use
RU2015151857A (en) 2008-12-02 2019-01-15 Уэйв Лайф Сайенсес Джапан, Инк. METHOD FOR SYNTHESIS OF NUCLEIC ACIDS MODIFIED BY PHOSPHOR ATOMIC
MX342945B (en) 2009-07-06 2016-10-18 Ontorii Inc * Novel nucleic acid prodrugs and methods use thereof.
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
EP3248982A1 (en) 2011-07-19 2017-11-29 Wave Life Sciences Ltd. Thiosulfonate reagents for the synthesis of functionalized nucleic acids
CA2879066C (en) 2012-07-13 2019-08-13 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
CA2879023C (en) 2012-07-13 2017-03-28 Wave Life Sciences Japan Asymmetric auxiliary group
CN104661664B (en) 2012-07-13 2020-07-03 波涛生命科学有限公司 Chiral control
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
JPWO2015108048A1 (en) 2014-01-15 2017-03-23 株式会社新日本科学 Chiral nucleic acid adjuvant and antitumor agent having antitumor activity
MX2016009290A (en) 2014-01-16 2017-02-28 Wave Life Sciences Ltd Chiral design.
JP7235512B2 (en) * 2016-06-24 2023-03-08 バイオジェン・エムエイ・インコーポレイテッド Synthesis of thiolated oligonucleotides without a capping step
CN116333006A (en) * 2023-04-07 2023-06-27 苏州欧利生物医药科技有限公司 Solid phase synthesis method of oligonucleotide with fluorescent marker

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4816571A (en) 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
US5750666A (en) * 1988-05-26 1998-05-12 Competitve Technologies, Inc. Polynucleotide phosphorodithioate compounds
US5149798A (en) * 1989-04-06 1992-09-22 Worcester Foundation For Experimental Biology Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses
US5859221A (en) 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5166387A (en) * 1990-01-12 1992-11-24 Applied Biosystems, Inc. Method of synthesizing sulfurized oligonucleotide analogs with thiuram disulfides
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5424184A (en) * 1991-05-08 1995-06-13 Regents Of The University Of Minnesota DNA sequence-based HLA class I typing method
ATE239484T1 (en) 1991-10-24 2003-05-15 Isis Pharmaceuticals Inc DERIVATIZED OLIGONUCLEOTIDES WITH IMPROVED ABSORPTION CAPACITY
US5614621A (en) * 1993-07-29 1997-03-25 Isis Pharmaceuticals, Inc. Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
US6653458B1 (en) * 1993-09-03 2003-11-25 Isis Pharmaceuticals, Inc. Modified oligonucleotides
US6399765B1 (en) * 1999-03-17 2002-06-04 Isis Pharmaceuticals, Inc. Methods for removing dimethoxytrityl groups from oligonucleotides
US6809195B1 (en) * 2000-08-16 2004-10-26 Isis Pharmaceuticals, Inc. Process for the preparation of oligonucleotides

Also Published As

Publication number Publication date
US6809195B1 (en) 2004-10-26
WO2002014340A1 (en) 2002-02-21
EP1311526A1 (en) 2003-05-21
US20040198972A1 (en) 2004-10-07

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