AU2001235284A1 - Methods and compositions for improving sleep - Google Patents
Methods and compositions for improving sleepInfo
- Publication number
- AU2001235284A1 AU2001235284A1 AU2001235284A AU3528401A AU2001235284A1 AU 2001235284 A1 AU2001235284 A1 AU 2001235284A1 AU 2001235284 A AU2001235284 A AU 2001235284A AU 3528401 A AU3528401 A AU 3528401A AU 2001235284 A1 AU2001235284 A1 AU 2001235284A1
- Authority
- AU
- Australia
- Prior art keywords
- sleep
- mimetic
- patch
- subject
- disorders
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18408700P | 2000-02-22 | 2000-02-22 | |
| US60/184,087 | 2000-02-22 | ||
| US23672700P | 2000-10-02 | 2000-10-02 | |
| US60/236,727 | 2000-10-02 | ||
| PCT/CA2001/000207 WO2001062290A2 (fr) | 2000-02-22 | 2001-02-22 | Methodes et compositions destinees a ameliorer la qualite du sommeil |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001235284A1 true AU2001235284A1 (en) | 2001-09-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001235284A Abandoned AU2001235284A1 (en) | 2000-02-22 | 2001-02-22 | Methods and compositions for improving sleep |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6586478B2 (fr) |
| EP (1) | EP1267862A2 (fr) |
| JP (1) | JP2003523405A (fr) |
| KR (1) | KR20020097182A (fr) |
| AU (1) | AU2001235284A1 (fr) |
| CA (1) | CA2400708A1 (fr) |
| MX (1) | MXPA02008101A (fr) |
| WO (1) | WO2001062290A2 (fr) |
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| US20110196039A9 (en) * | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
| US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
| CA2459647A1 (fr) * | 2001-08-20 | 2003-02-27 | University Of Virginia Patent Foundation | Utilisation de signalisation s-nitrosothiol pour le traitement de troubles du controle respiratoire |
| JP2005524676A (ja) * | 2002-03-20 | 2005-08-18 | ザ・ユニバーシティ・オブ・クイーンズランド | 一酸化窒素供与体及びオピオイド鎮痛薬を含む方法及び組成物 |
| ES2310258T5 (es) * | 2002-08-30 | 2012-05-31 | Kyowa Hakko Kogyo Co., Ltd. | Antagonistas de los receptores de adenosina A2A para tratar el síndrome de piernas inquietas o mioclono nocturno |
| US20040200472A1 (en) * | 2003-01-09 | 2004-10-14 | Suny Stony Brook/Respironics | Method of treating functional somatic syndromes and diagnosing sleep disorders based on functional somatic syndrome symptoms |
| US20050095278A1 (en) * | 2003-01-14 | 2005-05-05 | Viorel Nicolaescu | Use of nitroglycerin to relieve nocturnal muscle cramps |
| WO2004080487A1 (fr) * | 2003-03-13 | 2004-09-23 | Eisai Co. Ltd. | Medicament destine a prevenir ou a traiter les grincements de dents |
| US20040213828A1 (en) * | 2003-04-23 | 2004-10-28 | Smith David J. | Pain relief lollipop compositions and methods |
| US20040254202A1 (en) * | 2003-06-13 | 2004-12-16 | The Procter & Gamble Company | Method of promoting sleep using topical administration of vasoactive agents |
| US8114909B2 (en) * | 2003-09-17 | 2012-02-14 | Xenoport, Inc. | Treating or preventing restless legs syndrome using prodrugs of GABA analogs |
| US20050065175A1 (en) * | 2003-09-24 | 2005-03-24 | Xanodyne Pharmacal, Inc. | Oral transmucosal methadone |
| EP1715853A4 (fr) * | 2004-02-17 | 2012-07-18 | Transcept Pharmaceuticals Inc | Compositions permettant d'administrer des agents hypnotiques dans la muqueuse orale et methodes d'utilisation |
| WO2005084538A1 (fr) * | 2004-02-27 | 2005-09-15 | Axon Sleep Research Laboratories, Inc. | Dispositif et methode de prediction de la phase de sommeil d'un utilisateur |
| US7094207B1 (en) | 2004-03-02 | 2006-08-22 | Pacesetter, Inc. | System and method for diagnosing and tracking congestive heart failure based on the periodicity of cheyne-stokes respiration using an implantable medical device |
| US7070568B1 (en) | 2004-03-02 | 2006-07-04 | Pacesetter, Inc. | System and method for diagnosing and tracking congestive heart failure based on the periodicity of Cheyne-Stokes Respiration using an implantable medical device |
| US7179229B1 (en) | 2004-04-07 | 2007-02-20 | Pacesetter, Inc. | System and method for apnea detection using blood pressure detected via an implantable medical system |
| EP1740162A4 (fr) * | 2004-04-29 | 2009-11-18 | Caldwell Galer Inc | Compositions de methadone topiques et procedes pour les utiliser |
| US7371220B1 (en) | 2004-06-30 | 2008-05-13 | Pacesetter, Inc. | System and method for real-time apnea/hypopnea detection using an implantable medical system |
| US7361146B1 (en) | 2004-11-24 | 2008-04-22 | Pacesetter, Inc. | System and method for detecting abnormal respiration via respiratory parameters derived from intracardiac electrogram signals |
| US8262578B1 (en) | 2004-11-24 | 2012-09-11 | Pacesetter, Inc. | System and method for detecting physiologic states based on intracardiac electrogram signals while distinguishing cardiac rhythm types |
| US7435221B1 (en) | 2004-11-24 | 2008-10-14 | Pacesetter, Inc. | System and method for detecting abnormal respiration based on intracardiac electrogram signals using a pattern recognition device |
| US20060130833A1 (en) * | 2004-12-16 | 2006-06-22 | Magdy Younes | Treatment of obstructive sleep apnea |
| JP2008525321A (ja) | 2004-12-24 | 2008-07-17 | ザ ユニバーシティー オブ クイーンズランド | 疼痛治療法 |
| US7404799B1 (en) | 2005-04-05 | 2008-07-29 | Pacesetter, Inc. | System and method for detection of respiration patterns via integration of intracardiac electrogram signals |
| JP5053535B2 (ja) * | 2005-05-13 | 2012-10-17 | 協和発酵バイオ株式会社 | 寝つきまたは寝起き改善用経口剤 |
| US20070287740A1 (en) * | 2005-05-25 | 2007-12-13 | Transcept Pharmaceuticals, Inc. | Compositions and methods of treating middle-of-the night insomnia |
| US20070123562A1 (en) * | 2005-05-25 | 2007-05-31 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the-night insomnia |
| US20070225322A1 (en) * | 2005-05-25 | 2007-09-27 | Transoral Pharmaceuticals, Inc. | Compositions and methods for treating middle-of-the night insomnia |
| US7628757B1 (en) | 2005-05-25 | 2009-12-08 | Pacesetter, Inc. | System and method for impedance-based detection of pulmonary edema and reduced respiration using an implantable medical system |
| US8041429B2 (en) * | 2005-10-18 | 2011-10-18 | Ric Investments, Llc | System and method for controlling hypothalamic function via vestibular stimulation |
| US8468029B2 (en) * | 2005-11-17 | 2013-06-18 | The Invention Science Fund I, Llc | Subscriptions for assistance related to health |
| US10042980B2 (en) | 2005-11-17 | 2018-08-07 | Gearbox Llc | Providing assistance related to health |
| US20070299693A1 (en) * | 2006-06-23 | 2007-12-27 | Searete Llc, A Limited Liability Corporation | Customized visual marking for medication labeling |
| US20080114577A1 (en) * | 2005-11-30 | 2008-05-15 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Computational methods and systems associated with nutraceutical related assays |
| US10296720B2 (en) | 2005-11-30 | 2019-05-21 | Gearbox Llc | Computational systems and methods related to nutraceuticals |
| US20080199538A1 (en) * | 2006-01-10 | 2008-08-21 | Yronne Filopelrick | Compound to enhance lucid erotic dreams |
| WO2007098200A2 (fr) * | 2006-02-16 | 2007-08-30 | Imthera Medical, Inc. | Appareil, système et procédé rfid de traitement thérapeutique de l'apnée obstructive du sommeil |
| US20080086339A1 (en) * | 2006-06-23 | 2008-04-10 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Customized visual marking for medication labeling |
| US20080086338A1 (en) * | 2006-06-23 | 2008-04-10 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Customized visual marking for medication labeling |
| JP5649265B2 (ja) * | 2006-07-27 | 2015-01-07 | 江崎グリコ株式会社 | 睡眠改善剤 |
| US20080057144A1 (en) * | 2006-09-01 | 2008-03-06 | Cathy Beggan | Wake up on time dietary supplement and method of use |
| WO2008070148A1 (fr) * | 2006-12-05 | 2008-06-12 | Axon Sleep Research Laboratories, Inc. | Dispositif de support de pression avec dispositif de stratification du sommeil à électrodes sèches |
| US20080193385A1 (en) * | 2007-02-08 | 2008-08-14 | Todd Maibach | Compositions and methods for treating neuropathy |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| MX2009010450A (es) * | 2007-03-27 | 2009-11-23 | Omeros Corp | El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento. |
| CN101939043A (zh) * | 2007-10-09 | 2011-01-05 | 伊姆特拉医疗公司 | 用于选择性刺激的装置、系统和方法 |
| US20090191257A1 (en) * | 2008-01-29 | 2009-07-30 | Innovative Pharmaceuticals, Llc | Pain relief lollipop compositions and methods |
| BRPI0920548B8 (pt) | 2008-10-09 | 2021-06-22 | Imthera Medical Inc | aparelho para controlar posição da língua de um paciente |
| US8690933B2 (en) * | 2009-08-31 | 2014-04-08 | Brigham Young University | System and method for treating symptoms of restless legs syndrome |
| KR20120101650A (ko) | 2009-11-10 | 2012-09-14 | 임테라 메디칼, 인코포레이티드 | 환자 혀의 위치를 제어하기 위한 혀밑 신경 자극용 시스템 |
| US9415048B2 (en) * | 2010-07-08 | 2016-08-16 | Wellesley Pharmaceuticals, Llc | Pharmaceutical formulation for reducing frequency of urination and method of use thereof |
| US8844537B1 (en) | 2010-10-13 | 2014-09-30 | Michael T. Abramson | System and method for alleviating sleep apnea |
| AU2011336358B2 (en) * | 2010-12-03 | 2016-09-29 | VERO Biotech LLC. | Nitric oxide treatments |
| US20130064803A1 (en) * | 2011-09-14 | 2013-03-14 | Naidu Lp | BIO-REPLENISHMENT (BioRep) FOR COGNITIVE HEALTH |
| US9186479B1 (en) | 2014-06-05 | 2015-11-17 | Morphy Inc. | Methods and systems for gathering human biological signals and controlling a bed device |
| US9694156B2 (en) | 2014-06-05 | 2017-07-04 | Eight Sleep Inc. | Bed device system and methods |
| AU2016337564A1 (en) * | 2015-10-15 | 2018-05-31 | Drug Rediscovery Group Ltd | Low dose oral dipyridamole compositions and uses thereof |
| US10154932B2 (en) | 2015-11-16 | 2018-12-18 | Eight Sleep Inc. | Adjustable bedframe and operating methods for health monitoring |
| US10105092B2 (en) | 2015-11-16 | 2018-10-23 | Eight Sleep Inc. | Detecting sleeping disorders |
| WO2017168174A1 (fr) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | Nouvelles formes pharmaceutiques du sildénafil |
| WO2019139939A1 (fr) | 2018-01-09 | 2019-07-18 | Eight Sleep, Inc. | Systèmes et procédés de détection de signal biologique d'un utilisateur d'article de mobilier |
| WO2019143953A1 (fr) | 2018-01-19 | 2019-07-25 | Eight Sleep Inc. | Capsule de repos |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728705A (en) * | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
| TW458776B (en) | 1995-08-15 | 2001-10-11 | Chugai Pharmaceutical Co Ltd | Pharmaceutical composition for the treatment of anxiety neurosis |
| US6155976A (en) * | 1997-03-14 | 2000-12-05 | Nims, Inc. | Reciprocating movement platform for shifting subject to and fro in headwards-footwards direction |
| HUP0103113A3 (en) | 1998-08-11 | 2002-02-28 | Pfizer Prod Inc | New pharmaceutical compositions uses for nos inhibitors |
| US6417207B1 (en) | 1999-05-12 | 2002-07-09 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
-
2001
- 2001-02-22 EP EP01907282A patent/EP1267862A2/fr not_active Withdrawn
- 2001-02-22 AU AU2001235284A patent/AU2001235284A1/en not_active Abandoned
- 2001-02-22 MX MXPA02008101A patent/MXPA02008101A/es unknown
- 2001-02-22 US US09/791,127 patent/US6586478B2/en not_active Expired - Fee Related
- 2001-02-22 JP JP2001561354A patent/JP2003523405A/ja not_active Withdrawn
- 2001-02-22 KR KR1020027010974A patent/KR20020097182A/ko not_active Withdrawn
- 2001-02-22 CA CA002400708A patent/CA2400708A1/fr not_active Abandoned
- 2001-02-22 WO PCT/CA2001/000207 patent/WO2001062290A2/fr not_active Ceased
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2003
- 2003-03-11 US US10/387,269 patent/US20030195140A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| US20020015740A1 (en) | 2002-02-07 |
| US6586478B2 (en) | 2003-07-01 |
| KR20020097182A (ko) | 2002-12-31 |
| US20030195140A1 (en) | 2003-10-16 |
| JP2003523405A (ja) | 2003-08-05 |
| CA2400708A1 (fr) | 2001-08-30 |
| MXPA02008101A (es) | 2005-04-19 |
| EP1267862A2 (fr) | 2003-01-02 |
| WO2001062290A3 (fr) | 2002-08-01 |
| WO2001062290A2 (fr) | 2001-08-30 |
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