AU2001292749A1 - Twin-arginine translocation in bacillus - Google Patents
Twin-arginine translocation in bacillusInfo
- Publication number
- AU2001292749A1 AU2001292749A1 AU2001292749A AU9274901A AU2001292749A1 AU 2001292749 A1 AU2001292749 A1 AU 2001292749A1 AU 2001292749 A AU2001292749 A AU 2001292749A AU 9274901 A AU9274901 A AU 9274901A AU 2001292749 A1 AU2001292749 A1 AU 2001292749A1
- Authority
- AU
- Australia
- Prior art keywords
- gram
- host cell
- bacillus
- protein
- secretion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 241000193830 Bacillus <bacterium> Species 0.000 title abstract 2
- 239000004475 Arginine Substances 0.000 title 1
- 230000005945 translocation Effects 0.000 title 1
- 235000018102 proteins Nutrition 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 244000005700 microbiome Species 0.000 abstract 3
- 230000028327 secretion Effects 0.000 abstract 3
- 108010076504 Protein Sorting Signals Proteins 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 241000520272 Pantoea Species 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 101150107164 phoD gene Proteins 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 235000004252 protein component Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cereal-Derived Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23361000P | 2000-09-18 | 2000-09-18 | |
| US60/233,610 | 2000-09-18 | ||
| PCT/US2001/029151 WO2002022667A2 (fr) | 2000-09-18 | 2001-09-17 | Translocation des arginines couplees dans bacillus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001292749A1 true AU2001292749A1 (en) | 2002-03-26 |
Family
ID=22877967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001292749A Abandoned AU2001292749A1 (en) | 2000-09-18 | 2001-09-17 | Twin-arginine translocation in bacillus |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7316924B2 (fr) |
| EP (1) | EP1356060B1 (fr) |
| AT (1) | ATE312932T1 (fr) |
| AU (1) | AU2001292749A1 (fr) |
| DE (1) | DE60115958T2 (fr) |
| DK (1) | DK1356060T3 (fr) |
| WO (1) | WO2002022667A2 (fr) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
| US7655249B2 (en) * | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7901693B2 (en) * | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7553494B2 (en) * | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| US7419783B2 (en) | 2001-11-05 | 2008-09-02 | Research Development Foundation | Engineering of leader peptides for the secretion of recombinant proteins in bacteria |
| CN100564540C (zh) * | 2001-11-05 | 2009-12-02 | 研究发展基金会 | 构建分泌细菌重组蛋白的前导肽 |
| US20030219870A1 (en) * | 2002-03-23 | 2003-11-27 | George Georgiou | Secretion of proteins with multiple disulfide bonds in bacteria and uses thereof |
| DE10256669B4 (de) * | 2002-12-04 | 2006-03-09 | Universitätsklinikum Charité an der Humboldt-Universität zu Berlin Technologietransferstelle | Gemisch mindestens zweier Fusionsproteine sowie ihre Herstellung und Verwendung |
| EP1748077B1 (fr) * | 2004-04-20 | 2013-02-27 | Ajinomoto Co., Inc. | Procédé consistant à produire une protéine |
| US20070026012A1 (en) * | 2005-08-01 | 2007-02-01 | Cornell Research Foundation, Inc. | Compositions and methods for monitoring and altering protein folding and solubility |
| WO2007024877A2 (fr) * | 2005-08-22 | 2007-03-01 | Cornell Research Foundation, Inc. | Compositions et methodes permettant d'analyser des interactions de proteines |
| KR100742218B1 (ko) | 2005-10-21 | 2007-07-24 | 학교법인 포항공과대학교 | 트윈 아르기닌 트랜스로케이션 분비경로를 가지는오가노포스포러스 하이드롤라제 분비서열을 이용한대장균에서의 목적 외래 단백질 분비 |
| EP2076591A2 (fr) | 2006-10-20 | 2009-07-08 | Danisco US, INC., Genencor Division | Polyol oxydases |
| EP2431470B1 (fr) | 2006-11-30 | 2017-11-29 | Novozymes A/S | Expression d'une dnase dans des cellules hôtes recombinées |
| WO2008089132A2 (fr) * | 2007-01-12 | 2008-07-24 | Cornell Research Foundation, Inc. | Sélection génétique pour le repliement des protéines et la solubilité dans le périplasme bactérien |
| KR20100024943A (ko) * | 2007-06-18 | 2010-03-08 | 다니스코 유에스 인크. | 원핵생물에서의 단백질 생성을 위한 ｔａｔ 신호 펩타이드 |
| DE102008025791A1 (de) | 2008-05-29 | 2009-12-03 | Henkel Ag & Co. Kgaa | Sekretionsoptimierter Mikroorganismus |
| DE102008025926A1 (de) | 2008-05-29 | 2009-12-03 | Henkel Ag & Co. Kgaa | Sekretionsoptimierter Mikroorganismus |
| LT3044320T (lt) * | 2013-09-11 | 2020-06-10 | Impossible Foods Inc. | Hemo turinčių polipeptidų sekrecija |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| SI3294762T1 (sl) | 2015-05-11 | 2022-09-30 | Impossible Foods Inc. | Ekspresijski konstrukti in metode genskega inženiringa metilotrofnih kvasovk |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR101791526B1 (ko) * | 2016-02-18 | 2017-11-01 | (주)케어젠 | 발모 촉진 활성을 나타내는 펩타이드 및 이의 용도 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| GB201713732D0 (en) * | 2017-08-25 | 2017-10-11 | Alta Innovations Ltd | Tat expression system |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| PH12021552674A1 (en) | 2019-04-25 | 2022-07-04 | Impossible Foods Inc | Strains and methods for production of heme-containing proteins |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| FI110007B (fi) * | 1990-02-28 | 2002-11-15 | Dsm Nv | Menetelmä proteiinien tuottamiseksi |
| US5641671A (en) * | 1990-07-06 | 1997-06-24 | Unilever Patent Holdings B.V. | Production of active Pseudomonas glumae lipase in homologous or heterologous hosts |
| EP1068339B1 (fr) | 1998-04-01 | 2008-07-23 | The Governors of the University of Alberta | Compositions et methodes de secretion proteique |
| EP1354056B1 (fr) * | 2000-10-10 | 2014-11-26 | Danisco US Inc. | Secretion amelioree d'un polypeptide par un micro-organisme |
-
2001
- 2001-09-17 AT AT01973140T patent/ATE312932T1/de not_active IP Right Cessation
- 2001-09-17 WO PCT/US2001/029151 patent/WO2002022667A2/fr not_active Ceased
- 2001-09-17 EP EP01973140A patent/EP1356060B1/fr not_active Expired - Lifetime
- 2001-09-17 DK DK01973140T patent/DK1356060T3/da active
- 2001-09-17 US US09/954,737 patent/US7316924B2/en not_active Expired - Lifetime
- 2001-09-17 AU AU2001292749A patent/AU2001292749A1/en not_active Abandoned
- 2001-09-17 DE DE60115958T patent/DE60115958T2/de not_active Expired - Lifetime
-
2007
- 2007-06-01 US US11/809,669 patent/US7884192B2/en not_active Expired - Fee Related
- 2007-06-01 US US11/809,756 patent/US7897742B2/en not_active Expired - Fee Related
- 2007-06-01 US US11/809,528 patent/US7884191B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1356060A2 (fr) | 2003-10-29 |
| US7884191B2 (en) | 2011-02-08 |
| ATE312932T1 (de) | 2005-12-15 |
| US20020110860A1 (en) | 2002-08-15 |
| WO2002022667A3 (fr) | 2003-09-04 |
| US20090093025A1 (en) | 2009-04-09 |
| WO2002022667A9 (fr) | 2003-03-20 |
| WO2002022667A2 (fr) | 2002-03-21 |
| US7884192B2 (en) | 2011-02-08 |
| DE60115958D1 (en) | 2006-01-19 |
| US20080166757A1 (en) | 2008-07-10 |
| US7316924B2 (en) | 2008-01-08 |
| DE60115958T2 (de) | 2006-08-03 |
| EP1356060B1 (fr) | 2005-12-14 |
| DK1356060T3 (da) | 2006-05-01 |
| US7897742B2 (en) | 2011-03-01 |
| US20080248525A1 (en) | 2008-10-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2001292749A1 (en) | Twin-arginine translocation in bacillus | |
| WO1999058652A3 (fr) | Confinement biologique a base de cytotoxine | |
| IL157414A0 (en) | Fusion protein for the secretion of a protein of interest into the supernatant of the bacterial culture | |
| WO2002022821A3 (fr) | Peptides antimicrobiens et methodes d'utilisation | |
| CA2395266A1 (fr) | Utilisation de subtilisines stables en milieu acide dans des aliments pour animaux | |
| EP1288298A3 (fr) | Synthétases-tRNA de Staphylococcus Aureus | |
| AU2002228972A1 (en) | Polynucleotide encoding chimeric protein and related vectors, cells, and methods of expression thereof | |
| WO2002052029A9 (fr) | Methode permettant de produire une proteine de recombinaison et une proteine fusionnee | |
| WO2001048209A3 (fr) | Genes identifies comme etant requis pour la proliferation de e.coli | |
| AU2002309650A1 (en) | Highly conserved proteins from gram-positive bacteria | |
| WO2000044906A3 (fr) | Genes identifies intervenant dans la proliferation cellulaire d'escherichia coli | |
| WO2004056850A3 (fr) | Proteines mutantes a secretion accrue | |
| AU2002349231A1 (en) | Methylotrophic bacterium for the production of recombinant proteins and other products | |
| WO2001073082A3 (fr) | Procedes et cellules ameliores servant a exprimer des produits de proteine de recombinaison | |
| AU2002220215A1 (en) | Novel proteins and nucleic acids encoding same | |
| AU2002214542A1 (en) | Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof | |
| AU2002345213A1 (en) | Expression vectors encoding bacteriophage signal peptides | |
| AU4016089A (en) | The expression of homologous and heterologous proteins, which are able to function, on the outer membrane of e. coli and other gram-negative bacteria | |
| AU2002226074A1 (en) | E. coli 0157:h7 c1 esterase inhibitor-binding protein stce and uses thereof | |
| WO2002074799A3 (fr) | Toxine insecticide de $i(bacillus thuringiensis )modifiee$i( )sensible a la pepsine | |
| AU1183200A (en) | Novel gene encoding brain-specific membrane protein | |
| GR3025016T3 (en) | Protease deficient bacterial hosts | |
| ATE297990T1 (de) | Ftsy-exprimierende gram-positive mikroorganismen mit verbesserten sekretionseigenschaften | |
| AU8011498A (en) | Novel ppgpp synthetase and expression systems for improved production of proteinof interest | |
| WO2001034810A3 (fr) | Genes indispensables a une proliferation microbienne et antisens a cet egard |