AU2001273347A1 - Process for preparing benzoxazin-4-one polymer conjugates - Google Patents
Process for preparing benzoxazin-4-one polymer conjugatesInfo
- Publication number
- AU2001273347A1 AU2001273347A1 AU2001273347A AU7334701A AU2001273347A1 AU 2001273347 A1 AU2001273347 A1 AU 2001273347A1 AU 2001273347 A AU2001273347 A AU 2001273347A AU 7334701 A AU7334701 A AU 7334701A AU 2001273347 A1 AU2001273347 A1 AU 2001273347A1
- Authority
- AU
- Australia
- Prior art keywords
- benzoxazin
- base catalyst
- polymer conjugates
- preparing
- chloroformate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229920000642 polymer Polymers 0.000 title abstract 3
- HTWMTDKMOSSPMU-UHFFFAOYSA-N 1,2-benzoxazin-4-one Chemical compound C1=CC=C2C(=O)C=NOC2=C1 HTWMTDKMOSSPMU-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003054 catalyst Substances 0.000 abstract 3
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 230000010665 Enzyme Interactions Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000002532 enzyme inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Biological Depolymerization Polymers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Polyethers (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The present invention relates to a process for forming polymer conjugates which are useful as enzyme inhibitors. The process of the present invention comprises the steps of:a) reacting a polymer or copolymer alcohol to form a chloroformate;b) combining a substituted or unsubstituted anthranilic acid comprising an enzyme interaction attenuating unit; and a base catalyst wherein the base catalyst is a supported base catalyst, to form a substrate reactive admixture; andc) adding to said chloroformate formed in step (a) said substrate reactive admixture formed in step (b) to form a benzoxazin-4-one conjugate.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21752100P | 2000-07-11 | 2000-07-11 | |
| US60217521 | 2000-07-11 | ||
| PCT/US2001/021816 WO2002004531A2 (en) | 2000-07-11 | 2001-07-11 | Process for preparing benzoxazin-4-one polymer conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001273347A1 true AU2001273347A1 (en) | 2002-01-21 |
Family
ID=22811417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001273347A Abandoned AU2001273347A1 (en) | 2000-07-11 | 2001-07-11 | Process for preparing benzoxazin-4-one polymer conjugates |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6504028B2 (en) |
| EP (1) | EP1299430B1 (en) |
| JP (1) | JP5000064B2 (en) |
| AT (1) | ATE304023T1 (en) |
| AU (1) | AU2001273347A1 (en) |
| CA (1) | CA2415547A1 (en) |
| DE (1) | DE60113266T2 (en) |
| MX (1) | MXPA02012882A (en) |
| WO (1) | WO2002004531A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6803496B2 (en) | 1997-09-10 | 2004-10-12 | The Procter & Gamble Company | Method for maintaining or improving skin health |
| US20030143186A1 (en) * | 2001-11-13 | 2003-07-31 | The Procter & Gamble Company | Protease enzyme inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1933212A1 (en) * | 1969-07-01 | 1971-01-07 | Bayer Ag | Process for the production of high molecular weight polybenzoxazinones |
| DE3000284A1 (en) * | 1980-01-05 | 1981-07-09 | Philips Patentverwaltung Gmbh, 2000 Hamburg | Alkylation of anthranilic acid cpds. - using solid inorganic base and quat. ammonium salt as catalyst or organic base to give regio-specificity |
| US4745116A (en) * | 1985-06-25 | 1988-05-17 | Syntex (U.S.A.) Inc. | 2-oxy-4H-3,1-benzoxazin-4-ones and related compounds and pharmaceutical use |
| US4874822A (en) * | 1988-04-07 | 1989-10-17 | Minnesota Mining And Manufacturing Company | Process for the acrylamidoacylation of alcohols |
| GB8820129D0 (en) * | 1988-08-24 | 1988-09-28 | Schering Agrochemicals Ltd | Fungicides |
| US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
| DE4022752A1 (en) * | 1990-07-18 | 1992-01-23 | Bayer Ag | NEW CARBONATES, THEIR PRODUCTION AND USE AS FLOW AGENTS |
| CA2065191A1 (en) * | 1991-04-30 | 1992-10-31 | William E. Slack | Process for the preparation of aromatic amines and the use of the amines so produced |
| US5428021A (en) * | 1994-01-27 | 1995-06-27 | Sri International | Human leukocyte elastase (HLE) inhibitors, and related pharmaceutical compositions and methods of use |
| JPH07309851A (en) * | 1994-05-16 | 1995-11-28 | Fuji Chem Ind Co Ltd | Production of benzooxazinon derivative |
| AR022204A1 (en) * | 1999-01-08 | 2002-09-04 | Norgine Bv | COMPOUND, PROCESS FOR PREPARATION, PHARMACEUTICAL COMPOSITION AND EDIBLE PRODUCT THAT UNDERSTANDS IT. |
| DE19946048A1 (en) * | 1999-09-25 | 2004-03-18 | Basf Coatings Ag | Resins containing carbamate groups, process for their preparation and their use |
-
2001
- 2001-06-26 US US09/891,475 patent/US6504028B2/en not_active Expired - Lifetime
- 2001-07-11 DE DE60113266T patent/DE60113266T2/en not_active Expired - Lifetime
- 2001-07-11 MX MXPA02012882A patent/MXPA02012882A/en active IP Right Grant
- 2001-07-11 AU AU2001273347A patent/AU2001273347A1/en not_active Abandoned
- 2001-07-11 WO PCT/US2001/021816 patent/WO2002004531A2/en not_active Ceased
- 2001-07-11 JP JP2002509392A patent/JP5000064B2/en not_active Expired - Fee Related
- 2001-07-11 EP EP01952614A patent/EP1299430B1/en not_active Expired - Lifetime
- 2001-07-11 AT AT01952614T patent/ATE304023T1/en not_active IP Right Cessation
- 2001-07-11 CA CA002415547A patent/CA2415547A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20020028934A1 (en) | 2002-03-07 |
| WO2002004531A2 (en) | 2002-01-17 |
| EP1299430B1 (en) | 2005-09-07 |
| WO2002004531A3 (en) | 2002-04-11 |
| EP1299430A2 (en) | 2003-04-09 |
| US6504028B2 (en) | 2003-01-07 |
| JP5000064B2 (en) | 2012-08-15 |
| DE60113266D1 (en) | 2005-10-13 |
| DE60113266T2 (en) | 2006-06-08 |
| ATE304023T1 (en) | 2005-09-15 |
| MXPA02012882A (en) | 2003-05-14 |
| CA2415547A1 (en) | 2002-01-17 |
| JP2004502840A (en) | 2004-01-29 |
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