AU2001261689A1 - Electrically conducting nanocomposite materials for biomedical applications - Google Patents

Electrically conducting nanocomposite materials for biomedical applications

Info

Publication number: AU2001261689A1
Authority: AU; Australia
Prior art keywords: electrically conducting; ceramic; nanocomposite according; biocompatible; nanoscale
Prior art date: 2000-05-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU2001261689A

Other languages

English (en)

Inventor

Pulickel Ajayan

Rena Bizios

Richard Siegel

Peter Supronowicz

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Rensselaer Polytechnic Institute

Original Assignee

Rensselaer Polytechnic Institute

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-16

Filing date

2001-05-16

Publication date

2001-11-26

2001-05-16 Application filed by Rensselaer Polytechnic Institute filed Critical Rensselaer Polytechnic Institute

2001-11-26 Publication of AU2001261689A1 publication Critical patent/AU2001261689A1/en

Status Abandoned legal-status Critical Current

Links

239000002114 nanocomposite Substances 0.000 title claims description 33
239000000463 material Substances 0.000 title description 10
230000000638 stimulation Effects 0.000 claims description 48
210000000963 osteoblast Anatomy 0.000 claims description 46
229920000747 poly(lactic acid) Polymers 0.000 claims description 39
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 33
239000000919 ceramic Substances 0.000 claims description 32
239000002041 carbon nanotube Substances 0.000 claims description 27
229910021393 carbon nanotube Inorganic materials 0.000 claims description 27
239000002131 composite material Substances 0.000 claims description 23
239000002086 nanomaterial Substances 0.000 claims description 22
229920000249 biocompatible polymer Polymers 0.000 claims description 20
238000000034 method Methods 0.000 claims description 19
239000000758 substrate Substances 0.000 claims description 17
229920000642 polymer Polymers 0.000 claims description 16
239000004626 polylactic acid Substances 0.000 claims description 15
239000007943 implant Substances 0.000 claims description 13
229910052751 metal Inorganic materials 0.000 claims description 12
239000002184 metal Substances 0.000 claims description 12
230000035755 proliferation Effects 0.000 claims description 11
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 10
239000002070 nanowire Substances 0.000 claims description 10
239000004020 conductor Substances 0.000 claims description 7
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 5
239000002071 nanotube Substances 0.000 claims description 5
239000004053 dental implant Substances 0.000 claims description 4
230000002708 enhancing effect Effects 0.000 claims description 3
229910052588 hydroxylapatite Inorganic materials 0.000 claims description 3
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 3
230000005672 electromagnetic field Effects 0.000 claims description 2
210000000988 bone and bone Anatomy 0.000 description 23
210000004027 cell Anatomy 0.000 description 20
229920001577 copolymer Polymers 0.000 description 19
-1 for example Polymers 0.000 description 16
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 14
229910052791 calcium Inorganic materials 0.000 description 14
239000011575 calcium Substances 0.000 description 14
230000014509 gene expression Effects 0.000 description 11
239000000203 mixture Substances 0.000 description 10
108090000623 proteins and genes Proteins 0.000 description 10
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 8
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 8
210000002744 extracellular matrix Anatomy 0.000 description 8
108090000573 Osteocalcin Proteins 0.000 description 7
102000004264 Osteopontin Human genes 0.000 description 7
108010081689 Osteopontin Proteins 0.000 description 7
238000002474 experimental method Methods 0.000 description 7
230000006870 function Effects 0.000 description 7
108010022452 Collagen Type I Proteins 0.000 description 6
241001465754 Metazoa Species 0.000 description 6
102000004067 Osteocalcin Human genes 0.000 description 6
102000009890 Osteonectin Human genes 0.000 description 6
108010077077 Osteonectin Proteins 0.000 description 6
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
238000004113 cell culture Methods 0.000 description 6
239000000945 filler Substances 0.000 description 6
238000000338 in vitro Methods 0.000 description 6
229910052500 inorganic mineral Inorganic materials 0.000 description 6
239000011707 mineral Substances 0.000 description 6
210000002997 osteoclast Anatomy 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
102000012422 Collagen Type I Human genes 0.000 description 5
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 5
102000018251 Hypoxanthine Phosphoribosyltransferase Human genes 0.000 description 5
108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 5
238000010171 animal model Methods 0.000 description 5
229940096422 collagen type i Drugs 0.000 description 5
102000002260 Alkaline Phosphatase Human genes 0.000 description 4
108020004774 Alkaline Phosphatase Proteins 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
108091003079 Bovine Serum Albumin Proteins 0.000 description 4
DHCLVCXQIBBOPH-UHFFFAOYSA-N Glycerol 2-phosphate Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 description 4
108010035042 Osteoprotegerin Proteins 0.000 description 4
102000008108 Osteoprotegerin Human genes 0.000 description 4
229920000954 Polyglycolide Polymers 0.000 description 4
239000012091 fetal bovine serum Substances 0.000 description 4
230000035876 healing Effects 0.000 description 4
238000001727 in vivo Methods 0.000 description 4
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 4
XXUPLYBCNPLTIW-UHFFFAOYSA-N octadec-7-ynoic acid Chemical compound CCCCCCCCCCC#CCCCCCC(O)=O XXUPLYBCNPLTIW-UHFFFAOYSA-N 0.000 description 4
230000011164 ossification Effects 0.000 description 4
239000002245 particle Substances 0.000 description 4
229920000728 polyester Polymers 0.000 description 4
230000004044 response Effects 0.000 description 4
230000003827 upregulation Effects 0.000 description 4
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
229920001397 Poly-beta-hydroxybutyrate Polymers 0.000 description 3
229920000331 Polyhydroxybutyrate Polymers 0.000 description 3
229920003232 aliphatic polyester Polymers 0.000 description 3
239000012620 biological material Substances 0.000 description 3
239000002299 complementary DNA Substances 0.000 description 3
210000004748 cultured cell Anatomy 0.000 description 3
230000005684 electric field Effects 0.000 description 3
238000005516 engineering process Methods 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
229920001432 poly(L-lactide) Polymers 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
230000008439 repair process Effects 0.000 description 3
229920005989 resin Polymers 0.000 description 3
239000011347 resin Substances 0.000 description 3
239000000523 sample Substances 0.000 description 3
239000000377 silicon dioxide Substances 0.000 description 3
229910001220 stainless steel Inorganic materials 0.000 description 3
239000010935 stainless steel Substances 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
LTPBRCUWZOMYOC-UHFFFAOYSA-N Beryllium oxide Chemical compound O=[Be] LTPBRCUWZOMYOC-UHFFFAOYSA-N 0.000 description 2
208000010392 Bone Fractures Diseases 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
102000016921 Integrin-Binding Sialoprotein Human genes 0.000 description 2
108010028750 Integrin-Binding Sialoprotein Proteins 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
238000012408 PCR amplification Methods 0.000 description 2
229920001244 Poly(D,L-lactide) Polymers 0.000 description 2
239000004952 Polyamide Substances 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
229910052581 Si3N4 Inorganic materials 0.000 description 2
MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
238000002835 absorbance Methods 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
235000010323 ascorbic acid Nutrition 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
229920002988 biodegradable polymer Polymers 0.000 description 2
239000004621 biodegradable polymer Substances 0.000 description 2
230000033558 biomineral tissue development Effects 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
210000002805 bone matrix Anatomy 0.000 description 2
230000003915 cell function Effects 0.000 description 2
230000004663 cell proliferation Effects 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000000470 constituent Substances 0.000 description 2
230000008021 deposition Effects 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000009472 formulation Methods 0.000 description 2
239000012212 insulator Substances 0.000 description 2
229910052749 magnesium Inorganic materials 0.000 description 2
239000011777 magnesium Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
150000002734 metacrylic acid derivatives Chemical class 0.000 description 2
210000000056 organ Anatomy 0.000 description 2
239000012071 phase Substances 0.000 description 2
239000000049 pigment Substances 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
229920000117 poly(dioxanone) Polymers 0.000 description 2
229920002647 polyamide Polymers 0.000 description 2
229920001470 polyketone Polymers 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
229920002635 polyurethane Polymers 0.000 description 2
239000004814 polyurethane Substances 0.000 description 2
229920006216 polyvinyl aromatic Polymers 0.000 description 2
229920001291 polyvinyl halide Polymers 0.000 description 2
230000008569 process Effects 0.000 description 2
HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 2
229910010271 silicon carbide Inorganic materials 0.000 description 2
HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
229920003051 synthetic elastomer Polymers 0.000 description 2
239000005061 synthetic rubber Substances 0.000 description 2
230000017423 tissue regeneration Effects 0.000 description 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 1
229910052582 BN Inorganic materials 0.000 description 1
PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
102000029816 Collagenase Human genes 0.000 description 1
108060005980 Collagenase Proteins 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
229920001651 Cyanoacrylate Polymers 0.000 description 1
108700039887 Essential Genes Proteins 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical class OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 1
241000282412 Homo Species 0.000 description 1
102000013462 Interleukin-12 Human genes 0.000 description 1
108010065805 Interleukin-12 Proteins 0.000 description 1
JHWNWJKBPDFINM-UHFFFAOYSA-N Laurolactam Chemical compound O=C1CCCCCCCCCCCN1 JHWNWJKBPDFINM-UHFFFAOYSA-N 0.000 description 1
229920000571 Nylon 11 Polymers 0.000 description 1
229920000299 Nylon 12 Polymers 0.000 description 1
229920002292 Nylon 6 Polymers 0.000 description 1
102100031475 Osteocalcin Human genes 0.000 description 1
108010089430 Phosphoproteins Proteins 0.000 description 1
102000007982 Phosphoproteins Human genes 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004696 Poly ether ether ketone Substances 0.000 description 1
229920001283 Polyalkylene terephthalate Polymers 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004642 Polyimide Substances 0.000 description 1
239000004721 Polyphenylene oxide Substances 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
229920001328 Polyvinylidene chloride Polymers 0.000 description 1
241000700157 Rattus norvegicus Species 0.000 description 1
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
239000002174 Styrene-butadiene Substances 0.000 description 1
RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
150000001241 acetals Chemical class 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
229920006397 acrylic thermoplastic Polymers 0.000 description 1
XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 1
239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
230000004913 activation Effects 0.000 description 1
230000001464 adherent effect Effects 0.000 description 1
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical class OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 1
230000002411 adverse Effects 0.000 description 1
239000011543 agarose gel Substances 0.000 description 1
229920000615 alginic acid Polymers 0.000 description 1
235000010443 alginic acid Nutrition 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
230000003321 amplification Effects 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000000137 annealing Methods 0.000 description 1
238000013459 approach Methods 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
239000011324 bead Substances 0.000 description 1
REKYPYSUBKSCAT-UHFFFAOYSA-N beta-hydroxyvaleric acid Natural products CCC(O)CC(O)=O REKYPYSUBKSCAT-UHFFFAOYSA-N 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
210000002449 bone cell Anatomy 0.000 description 1
MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
229910001576 calcium mineral Inorganic materials 0.000 description 1
QXJJQWWVWRCVQT-UHFFFAOYSA-K calcium;sodium;phosphate Chemical compound [Na+].[Ca+2].[O-]P([O-])([O-])=O QXJJQWWVWRCVQT-UHFFFAOYSA-K 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000006229 carbon black Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
108091092328 cellular RNA Proteins 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
229960002424 collagenase Drugs 0.000 description 1
239000002322 conducting polymer Substances 0.000 description 1
229920001940 conductive polymer Polymers 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
PMHQVHHXPFUNSP-UHFFFAOYSA-M copper(1+);methylsulfanylmethane;bromide Chemical compound Br[Cu].CSC PMHQVHHXPFUNSP-UHFFFAOYSA-M 0.000 description 1
229910052593 corundum Inorganic materials 0.000 description 1
239000010431 corundum Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000013461 design Methods 0.000 description 1
238000002405 diagnostic procedure Methods 0.000 description 1
230000004069 differentiation Effects 0.000 description 1
230000029087 digestion Effects 0.000 description 1
KZHJGOXRZJKJNY-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Si]=O.O=[Al]O[Al]=O.O=[Al]O[Al]=O.O=[Al]O[Al]=O KZHJGOXRZJKJNY-UHFFFAOYSA-N 0.000 description 1
KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
238000010891 electric arc Methods 0.000 description 1
230000005611 electricity Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000003822 epoxy resin Substances 0.000 description 1
ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
229960005542 ethidium bromide Drugs 0.000 description 1
229920001038 ethylene copolymer Polymers 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000005284 excitation Effects 0.000 description 1
229920002313 fluoropolymer Polymers 0.000 description 1
239000004811 fluoropolymer Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000003292 glue Substances 0.000 description 1
JFCQEDHGNNZCLN-UHFFFAOYSA-N glutaric acid Chemical class OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
239000010931 gold Substances 0.000 description 1
239000010439 graphite Substances 0.000 description 1
229910002804 graphite Inorganic materials 0.000 description 1
230000012010 growth Effects 0.000 description 1
LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
229920001903 high density polyethylene Polymers 0.000 description 1
239000004700 high-density polyethylene Substances 0.000 description 1
230000013632 homeostatic process Effects 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
230000036039 immunity Effects 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000010874 in vitro model Methods 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000011256 inorganic filler Substances 0.000 description 1
229910003475 inorganic filler Inorganic materials 0.000 description 1
229910003480 inorganic solid Inorganic materials 0.000 description 1
229940117681 interleukin-12 Drugs 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
230000007774 longterm Effects 0.000 description 1
229920001684 low density polyethylene Polymers 0.000 description 1
239000004702 low-density polyethylene Substances 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
150000002690 malonic acid derivatives Chemical class 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
229920001179 medium density polyethylene Polymers 0.000 description 1
239000004701 medium-density polyethylene Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
108020004999 messenger RNA Proteins 0.000 description 1
150000001247 metal acetylides Chemical class 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
239000010445 mica Substances 0.000 description 1
229910052618 mica group Inorganic materials 0.000 description 1
238000001000 micrograph Methods 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
229910052863 mullite Inorganic materials 0.000 description 1
239000002048 multi walled nanotube Substances 0.000 description 1
150000004767 nitrides Chemical class 0.000 description 1
231100001223 noncarcinogenic Toxicity 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000006911 nucleation Effects 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
229920001778 nylon Polymers 0.000 description 1
230000033667 organ regeneration Effects 0.000 description 1
239000012766 organic filler Substances 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
230000000399 orthopedic effect Effects 0.000 description 1
230000001582 osteoblastic effect Effects 0.000 description 1
150000003891 oxalate salts Chemical class 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
230000036961 partial effect Effects 0.000 description 1
239000008188 pellet Substances 0.000 description 1
210000000578 peripheral nerve Anatomy 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920001643 poly(ether ketone) Polymers 0.000 description 1
229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
229920006122 polyamide resin Polymers 0.000 description 1
229920001748 polybutylene Polymers 0.000 description 1
229920001707 polybutylene terephthalate Polymers 0.000 description 1
229920001610 polycaprolactone Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229920001225 polyester resin Polymers 0.000 description 1
239000004645 polyester resin Substances 0.000 description 1
229920006149 polyester-amide block copolymer Polymers 0.000 description 1
229920000570 polyether Polymers 0.000 description 1
229920002530 polyetherether ketone Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000921 polyethylene adipate Polymers 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
229920002643 polyglutamic acid Polymers 0.000 description 1
239000004633 polyglycolic acid Substances 0.000 description 1
229920001721 polyimide Polymers 0.000 description 1
239000002952 polymeric resin Substances 0.000 description 1
229920000098 polyolefin Polymers 0.000 description 1
229920005672 polyolefin resin Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
235000013824 polyphenols Nutrition 0.000 description 1
229920006380 polyphenylene oxide Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
239000004800 polyvinyl chloride Substances 0.000 description 1
229920000915 polyvinyl chloride Polymers 0.000 description 1
239000005033 polyvinylidene chloride Substances 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
238000012545 processing Methods 0.000 description 1
239000000047 product Substances 0.000 description 1
238000000275 quality assurance Methods 0.000 description 1
229920005604 random copolymer Polymers 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
230000001172 regenerating effect Effects 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000010839 reverse transcription Methods 0.000 description 1
238000003757 reverse transcription PCR Methods 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000012552 review Methods 0.000 description 1
239000005060 rubber Substances 0.000 description 1
238000004626 scanning electron microscopy Methods 0.000 description 1
CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical class OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 1
239000010703 silicon Substances 0.000 description 1
229910052710 silicon Inorganic materials 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
229910052596 spinel Inorganic materials 0.000 description 1
239000011029 spinel Substances 0.000 description 1
239000011115 styrene butadiene Substances 0.000 description 1
229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical class OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 1
150000003890 succinate salts Chemical class 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
230000009772 tissue formation Effects 0.000 description 1
229910052719 titanium Inorganic materials 0.000 description 1
239000010936 titanium Substances 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
239000010456 wollastonite Substances 0.000 description 1
229910052882 wollastonite Inorganic materials 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1
VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
229910052726 zirconium Inorganic materials 0.000 description 1
PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0003—Not used, see subgroups
- A61C8/0004—Consolidating natural teeth
- A61C8/0006—Periodontal tissue or bone regeneration
- A61C8/0007—Stimulation of growth around implant by electrical means
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/443—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2821—Bone stimulation by electromagnetic fields or electric current for enhancing ossification
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00161—Carbon; Graphite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00203—Ceramics or ceramic-like structures based on metal oxides containing alumina or aluminium oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00215—Ceramics or ceramic-like structures based on metal oxides containing silica or silicon oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00227—Ceramics or ceramic-like structures based on metal oxides containing titania or titanium oxide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00185—Ceramics or ceramic-like structures based on metal oxides
- A61F2310/00239—Ceramics or ceramic-like structures based on metal oxides containing zirconia or zirconium oxide ZrO2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00263—Ceramics or ceramic-like structures based on metal borides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00269—Ceramics or ceramic-like structures based on metal carbides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00269—Ceramics or ceramic-like structures based on metal carbides
- A61F2310/00281—Ceramics or ceramic-like structures based on metal carbides containing silicon carbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00299—Ceramics or ceramic-like structures based on metal nitrides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00299—Ceramics or ceramic-like structures based on metal nitrides
- A61F2310/00317—Ceramics or ceramic-like structures based on metal nitrides containing silicon nitride
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Oral & Maxillofacial Surgery (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Transplantation (AREA)
Dermatology (AREA)
Composite Materials (AREA)
Materials Engineering (AREA)
Orthopedic Medicine & Surgery (AREA)
Inorganic Chemistry (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Developmental Biology & Embryology (AREA)
Dentistry (AREA)
Pharmacology & Pharmacy (AREA)
Materials For Medical Uses (AREA)
Dental Prosthetics (AREA)
Conductive Materials (AREA)

AU2001261689A 2000-05-16 2001-05-16 Electrically conducting nanocomposite materials for biomedical applications Abandoned AU2001261689A1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US20441600P	2000-05-16	2000-05-16
US60204416		2000-05-16
PCT/US2001/015910 WO2001087193A1 (fr)	2000-05-16	2001-05-16	Materiaux nanocomposites electroconducteurs destines a des applications biomedicales

Publications (1)

Publication Number	Publication Date
AU2001261689A1 true AU2001261689A1 (en)	2001-11-26

Family

ID=22757779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU2001261689A Abandoned AU2001261689A1 (en)	2000-05-16	2001-05-16	Electrically conducting nanocomposite materials for biomedical applications

Country Status (6)

Country	Link
US (1)	US20030153965A1 (fr)
EP (1)	EP1289453A1 (fr)
JP (1)	JP2003533276A (fr)
AU (1)	AU2001261689A1 (fr)
CA (1)	CA2408172A1 (fr)
WO (1)	WO2001087193A1 (fr)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6723299B1 (en)	2001-05-17	2004-04-20	Zyvex Corporation	System and method for manipulating nanotubes
WO2003049795A2 (fr) *	2001-09-28	2003-06-19	Boston Scientific Limited	Dispositifs medicaux a nanocomposites
US6905667B1 (en)	2002-05-02	2005-06-14	Zyvex Corporation	Polymer and method for using the polymer for noncovalently functionalizing nanotubes
US20040034177A1 (en)	2002-05-02	2004-02-19	Jian Chen	Polymer and method for using the polymer for solubilizing nanotubes
US7162308B2 (en)	2002-11-26	2007-01-09	Wilson Greatbatch Technologies, Inc.	Nanotube coatings for implantable electrodes
GB2400605A (en) *	2003-02-18	2004-10-20	Univ Cardiff	Nanocomposites
US7993412B2 (en) *	2003-03-27	2011-08-09	Purdue Research Foundation	Nanofibers as a neural biomaterial
US7972616B2 (en)	2003-04-17	2011-07-05	Nanosys, Inc.	Medical device applications of nanostructured surfaces
US20050038498A1 (en) *	2003-04-17	2005-02-17	Nanosys, Inc.	Medical device applications of nanostructured surfaces
WO2004106420A2 (fr) *	2003-05-22	2004-12-09	Zyvex Corporation	Nanocomposites et procedes
US7354988B2 (en)	2003-08-12	2008-04-08	General Electric Company	Electrically conductive compositions and method of manufacture thereof
US7026432B2 (en)	2003-08-12	2006-04-11	General Electric Company	Electrically conductive compositions and method of manufacture thereof
US7309727B2 (en)	2003-09-29	2007-12-18	General Electric Company	Conductive thermoplastic compositions, methods of manufacture and articles derived from such compositions
US7369900B2 (en) *	2004-05-08	2008-05-06	Bojan Zdravkovic	Neural bridge devices and methods for restoring and modulating neural activity
US8057901B2 (en) *	2004-05-14	2011-11-15	Sony Deutschland Gmbh	Composite materials comprising carbon nanotubes and metal carbonates
EP1789477A2 (fr) *	2004-08-02	2007-05-30	University Of Houston	Nanocomposites polymeres renforces par des nanotubes de carbone
US7296576B2 (en)	2004-08-18	2007-11-20	Zyvex Performance Materials, Llc	Polymers for enhanced solubility of nanomaterials, compositions and methods therefor
US20060093642A1 (en) *	2004-11-03	2006-05-04	Ranade Shrirang V	Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology
JP2006143691A (ja) *	2004-11-24	2006-06-08	Jfe Engineering Kk	ナノカーボン物質からなる生体組織形成材料
WO2006067959A1 (fr)	2004-12-21	2006-06-29	Shinshu University	Instrument medical
US20060165926A1 (en) *	2005-01-27	2006-07-27	Jan Weber	Medical devices including nanocomposites
US7462656B2 (en)	2005-02-15	2008-12-09	Sabic Innovative Plastics Ip B.V.	Electrically conductive compositions and method of manufacture thereof
EP1879522A2 (fr)	2005-04-28	2008-01-23	The Regents of The University of California	Compositions comprenant des nanostructures destinées à la croissance de cellules, de tissus et d'organes artificiels, procédés de préparation et d'utilisation de ces dernières
AU2006249942B2 (en) *	2005-05-26	2011-07-07	Zimmer Dental, Inc.	Prosthetic dental device
US7439731B2 (en)	2005-06-24	2008-10-21	Crafts Douglas E	Temporary planar electrical contact device and method using vertically-compressible nanotube contact structures
KR20120128155A (ko) *	2005-08-12	2012-11-26	캄브리오스 테크놀로지즈 코포레이션	나노와이어 기반의 투명 도전체
WO2007025035A1 (fr)	2005-08-24	2007-03-01	University Of Houston	Nanocomposites de polymeres ayant des nanotubes disperses
US8562346B2 (en)	2005-08-30	2013-10-22	Zimmer Dental, Inc.	Dental implant for a jaw with reduced bone volume and improved osseointegration features
WO2007030752A2 (fr) *	2005-09-09	2007-03-15	University Of Arkansas At Little Rock	Systeme et procede de generation de tissus et de regeneration d'os
US9763788B2 (en)	2005-09-09	2017-09-19	Board Of Trustees Of The University Of Arkansas	Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US8936805B2 (en)	2005-09-09	2015-01-20	Board Of Trustees Of The University Of Arkansas	Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US20100023101A1 (en) *	2006-02-03	2010-01-28	University Of Wollongong	Biocompatible composites
CN103122132B (zh)	2006-07-20	2016-03-16	奥巴斯尼茨医学公司	用于医疗器械的可生物吸收聚合物组合物
US8354855B2 (en) *	2006-10-16	2013-01-15	Formfactor, Inc.	Carbon nanotube columns and methods of making and using carbon nanotube columns as probes
US8130007B2 (en)	2006-10-16	2012-03-06	Formfactor, Inc.	Probe card assembly with carbon nanotube probes having a spring mechanism therein
CN101631513B (zh)	2006-10-20	2013-06-05	奥巴斯尼茨医学公司	可生物吸收的聚合物组合物和医疗设备
US7959942B2 (en)	2006-10-20	2011-06-14	Orbusneich Medical, Inc.	Bioabsorbable medical device with coating
US7783360B2 (en)	2006-10-23	2010-08-24	Bojan Zdravkovic	Sensory system
US7783363B2 (en)	2006-10-23	2010-08-24	Artis Nanomedica, Inc.	Neural bridge gateway and calibrator
TWI317016B (en) *	2006-11-08	2009-11-11	Nat Univ Tsing Hua	Multifunctional nano-probe interface structure for neural prostheses and manufacturing method thereof
US7777397B2 (en) *	2007-03-12	2010-08-17	3M Innovative Properties Company	Multilayer conductive elements
US7897529B2 (en)	2007-03-23	2011-03-01	Lydall, Inc.	Substrate for carrying catalytic particles
JP2008289734A (ja) *	2007-05-25	2008-12-04	Yoshida Dental Mfg Co Ltd	骨芽細胞−基材複合体の作製方法
CA2694518A1 (fr)	2007-07-12	2009-01-15	Nanovis, Inc.	Procede permettant d'accroitre la fonction osteoblastique et de mesurer les proprietes electrochimiques d'un implant medical
US20090061389A1 (en)	2007-08-30	2009-03-05	Matthew Lomicka	Dental implant prosthetic device with improved osseointegration and shape for resisting rotation
US8149007B2 (en) *	2007-10-13	2012-04-03	Formfactor, Inc.	Carbon nanotube spring contact structures with mechanical and electrical components
CA2711177A1 (fr) *	2007-12-31	2009-07-16	3M Innovative Properties Company	Pansement medical avec orifice de bordure et son procede d'utilisation
WO2009142340A1 (fr) *	2008-05-19	2009-11-26	Vericom Co., Ltd.	Composition dentaire contenant un nanotube organique
US9095396B2 (en)	2008-07-02	2015-08-04	Zimmer Dental, Inc.	Porous implant with non-porous threads
US8562348B2 (en)	2008-07-02	2013-10-22	Zimmer Dental, Inc.	Modular implant with secured porous portion
US8899982B2 (en)	2008-07-02	2014-12-02	Zimmer Dental, Inc.	Implant with structure for securing a porous portion
US7935259B2 (en) *	2008-07-03	2011-05-03	The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration	Filtering apparatus and method of use
US10086079B2 (en)	2008-08-11	2018-10-02	Fibralign Corporation	Biocomposites and methods of making the same
US20100114314A1 (en)	2008-11-06	2010-05-06	Matthew Lomicka	Expandable bone implant
US20100217339A1 (en) *	2009-02-23	2010-08-26	Kane Seth A	Carbon nanotube micro-array relay system for providing nerve sitmulation output and sensation input acrodd proximal and distal ends of damaged spinal cord
US8272124B2 (en) *	2009-04-03	2012-09-25	Formfactor, Inc.	Anchoring carbon nanotube columns
US20100252317A1 (en) *	2009-04-03	2010-10-07	Formfactor, Inc.	Carbon nanotube contact structures for use with semiconductor dies and other electronic devices
CN102802571B (zh)	2009-06-16	2016-08-03	3M创新有限公司	具有自支承基底的适形医用敷料
US9707058B2 (en)	2009-07-10	2017-07-18	Zimmer Dental, Inc.	Patient-specific implants with improved osseointegration
US20110085968A1 (en) *	2009-10-13	2011-04-14	The Regents Of The University Of California	Articles comprising nano-materials for geometry-guided stem cell differentiation and enhanced bone growth
US20110089041A1 (en) *	2009-10-19	2011-04-21	Biomet Manufacturing Corp.	Methods of depositing discrete hydroxyapatite regions on medical implants
US8602782B2 (en)	2009-11-24	2013-12-10	Zimmer Dental, Inc.	Porous implant device with improved core
US20110143127A1 (en) *	2009-12-11	2011-06-16	Biomet Manufacturing Corp.	Methods for coating implants
US10065046B2 (en)	2010-07-15	2018-09-04	Fibralign Corporation	Conductive biopolymer implant for enhancing tissue repair and regeneration using electromagnetic fields
EP2613818B1 (fr)	2010-09-10	2019-02-13	Fibralign Corp.	Constructions multicouches biodégradables
US8872176B2 (en)	2010-10-06	2014-10-28	Formfactor, Inc.	Elastic encapsulated carbon nanotube based electrical contacts
WO2012094208A1 (fr) *	2011-01-05	2012-07-12	Children's Medical Center Corporation	Échafaudages tissulaires tridimensionnels à nanofils
DE102013201885A1 (de) *	2013-02-05	2014-08-07	Urs Brodbeck	Keramikkörper, insbesondere zur Verwendung in einem Knochenimplantat, insbesondere als Dentalimplantat
CN104945281B (zh) *	2014-03-31	2017-04-26	中国人民解放军军事医学科学院毒物药物研究所	黄酮乙酸类衍生物、其药物组合物、其制备方法及用途
JP6454550B2 (ja) *	2015-01-07	2019-01-16	株式会社日本触媒	生体適合性材料
US10018615B2 (en) *	2016-03-08	2018-07-10	Lawrence Livermore National Security, Llc	Three-dimensional electronic scaffold for cardiac applications
DE102016107223B4 (de) *	2016-04-19	2018-05-24	Karl Leibinger Medizintechnik Gmbh & Co. Kg	Hybridimplantat aus einem Kompositmaterial
KR101905269B1 (ko) *	2016-11-11	2018-10-08	서강대학교산학협력단	패터닝된 하이드로젤을 이용한 신경줄기세포의 분화 방법
US20200281693A1 (en)	2017-10-26	2020-09-10	Universidade Do Minho	Dental implant with electrostimulation system and its production method
JP2021500189A (ja)	2017-10-26	2021-01-07	ユニベルズィダードドゥミンホＵｎｉｖｅｒｓｉｄａｄｅＤｏＭｉｎｈｏ	電気的治癒特性を有するジルコニアまたはアルミナから作られた歯科用インプラントおよびその製造方法
WO2020227288A1 (fr)	2019-05-06	2020-11-12	Kamran Ansari	Réseaux thérapeutiques de bobines planaires conçues pour générer des champs électromagnétiques pulsés et intégrés dans des vêtements
US11020603B2 (en)	2019-05-06	2021-06-01	Kamran Ansari	Systems and methods of modulating electrical impulses in an animal brain using arrays of planar coils configured to generate pulsed electromagnetic fields and integrated into clothing

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62202884A (ja) *	1986-02-28	1987-09-07	工業技術院長	生体代替セラミツク材料
DE69029735T2 (de) *	1989-09-15	1997-07-31	Chiron Vision Corp., Irvine, Calif.	Synthetisches material, das die anlagerung, das wachstum und die befestigung von epithelzellen fördert, prosthetische vorrichtung zur subepithelialen implantation sowie behandelte linse
WO1995006090A1 (fr) *	1993-08-23	1995-03-02	Alliedsignal Inc.	Nanocomposites polymeres comportant un polymere et un materiau particulaire exfolie derive a l'aide d'organosilanes, d'organotitanates et d'organozirconates disperses dans ledit materiau et leurs procedes de fabrication
US5843741A (en) *	1994-08-01	1998-12-01	Massachusetts Insitute Of Technology	Method for altering the differentiation of anchorage dependent cells on an electrically conducting polymer
US6041253A (en) *	1995-12-18	2000-03-21	Massachusetts Institute Of Technology	Effect of electric field and ultrasound for transdermal drug delivery
US5947921A (en) *	1995-12-18	1999-09-07	Massachusetts Institute Of Technology	Chemical and physical enhancers and ultrasound for transdermal drug delivery
US6013591A (en) *	1997-01-16	2000-01-11	Massachusetts Institute Of Technology	Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
DE19726412A1 (de) *	1997-06-21	1998-12-24	Merck Patent Gmbh	Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US6121027A (en) *	1997-08-15	2000-09-19	Surmodics, Inc.	Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
US6689823B1 (en) *	1999-03-31	2004-02-10	The Brigham And Women's Hospital, Inc.	Nanocomposite surgical materials and method of producing them
US6270347B1 (en) *	1999-06-10	2001-08-07	Rensselaer Polytechnic Institute	Nanostructured ceramics and composite materials for orthopaedic-dental implants

2001
- 2001-05-16 WO PCT/US2001/015910 patent/WO2001087193A1/fr not_active Ceased
- 2001-05-16 EP EP01935610A patent/EP1289453A1/fr not_active Withdrawn
- 2001-05-16 JP JP2001583664A patent/JP2003533276A/ja active Pending
- 2001-05-16 AU AU2001261689A patent/AU2001261689A1/en not_active Abandoned
- 2001-05-16 CA CA002408172A patent/CA2408172A1/fr not_active Abandoned
2002
- 2002-11-15 US US10/298,158 patent/US20030153965A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2001087193A1 (fr)	2001-11-22
EP1289453A1 (fr)	2003-03-12
US20030153965A1 (en)	2003-08-14
JP2003533276A (ja)	2003-11-11
CA2408172A1 (fr)	2001-11-22

Publication	Publication Date	Title
US20030153965A1 (en)	2003-08-14	Electrically conducting nanocomposite materials for biomedical applications
Supronowicz et al.	2002	Novel current‐conducting composite substrates for exposing osteoblasts to alternating current stimulation
Zhang et al.	2019	Multilayered titanium carbide MXene film for guided bone regeneration
McManus et al.	2005	Evaluation of cytocompatibility and bending modulus of nanoceramic/polymer composites
Ye et al.	2020	Nanomaterial-based scaffolds for bone tissue engineering and regeneration
Liu et al.	2006	Increased osteoblast functions among nanophase titania/poly (lactide‐co‐glycolide) composites of the highest nanometer surface roughness
US6270347B1 (en)	2001-08-07	Nanostructured ceramics and composite materials for orthopaedic-dental implants
Diao et al.	2018	3D‐plotted beta‐tricalcium phosphate scaffolds with smaller pore sizes improve in vivo bone regeneration and biomechanical properties in a critical‐sized calvarial defect rat model
Webster et al.	1999	Design and evaluation of nanophase alumina for orthopaedic/dental applications
US9186190B2 (en)	2015-11-17	Functionalized nanodiamond reinforced biopolymers
Chłopek et al.	2006	In vitro studies of carbon nanotubes biocompatibility
Sirivisoot et al.	2007	Greater osteoblast functions on multiwalled carbon nanotubes grown from anodizednanotubular titanium for orthopedic applications
Streicher et al.	2007	Nanosurfaces and nanostructures for artificial orthopedic implants
Ma et al.	2014	Improved implant osseointegration of a nanostructured titanium surface via mediation of macrophage polarization
Kim et al.	2004	Fluor-hydroxyapatite sol–gel coating on titanium substrate for hard tissue implants
Frosch et al.	2004	Growth behavior, matrix production, and gene expression of human osteoblasts in defined cylindrical titanium channels
Lavos‐Valereto et al.	2001	In vitro and in vivo biocompatibility testing of Ti‐6Al‐7Nb alloy with and without plasma‐sprayed hydroxyapatite coating
Tanaka et al.	2017	A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler
Zhao et al.	2022	Potential load-bearing bone substitution material: carbon-fiber-reinforced magnesium-doped hydroxyapatite composites with excellent mechanical performance and tailored biological properties
Misra et al.	2007	Poly (3-hydroxybutyrate)/Bioglass® composite films containing carbon nanotubes
Kim et al.	2010	Solid free-form fabrication-based PCL/HA scaffolds fabricated with a multi-head deposition system for bone tissue engineering
Cai et al.	2018	The effects of surface bioactivity and sustained-release of genistein from a mesoporous magnesium-calcium-silicate/PK composite stimulating cell responses in vitro, and promoting osteogenesis and enhancing osseointegration in vivo
Lu et al.	2016	The ameloblastin extracellular matrix molecule enhances bone fracture resistance and promotes rapid bone fracture healing
Zhang et al.	2023	Osteogenic differentiation of 3D-printed porous tantalum with nano-topographic modification for repairing craniofacial bone defects
Liao et al.	1997	Responses of bone to titania–hydroxyapatite composite and nacreous implants: a preliminary comparison by in situ hybridization