[go: up one dir, main page]

AU2001258677A1 - Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them - Google Patents

Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them

Info

Publication number
AU2001258677A1
AU2001258677A1 AU2001258677A AU5867701A AU2001258677A1 AU 2001258677 A1 AU2001258677 A1 AU 2001258677A1 AU 2001258677 A AU2001258677 A AU 2001258677A AU 5867701 A AU5867701 A AU 5867701A AU 2001258677 A1 AU2001258677 A1 AU 2001258677A1
Authority
AU
Australia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
novel compounds
antiinflammatory activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001258677A
Other languages
English (en)
Inventor
Seshagiri Rao Casturi
Prem Kumar Mamnoor
Parimal Misra
Manojit Pal
Rajagopalan Ramanujam
Koteswar Rao Yeleswarapu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Research Foundation
Original Assignee
Dr Reddys Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Research Foundation filed Critical Dr Reddys Research Foundation
Publication of AU2001258677A1 publication Critical patent/AU2001258677A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001258677A 2000-05-22 2001-05-21 Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them Abandoned AU2001258677A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN388/MAS/2000 2000-05-22
IN388MA2000 2000-05-22
IN436/MAS/2000 2000-06-08
IN436MA2000 2000-06-08
PCT/IB2001/000883 WO2001090097A2 (fr) 2000-05-22 2001-05-21 Nouveaux composes possedant une activite anti-inflammatoire, procede de preparation de ceux-ci et compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
AU2001258677A1 true AU2001258677A1 (en) 2001-12-03

Family

ID=26324893

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001258677A Abandoned AU2001258677A1 (en) 2000-05-22 2001-05-21 Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them

Country Status (6)

Country Link
US (1) US6686390B2 (fr)
CN (1) CN1443180A (fr)
AU (1) AU2001258677A1 (fr)
CA (1) CA2412651A1 (fr)
MX (1) MXPA03000161A (fr)
WO (1) WO2001090097A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19818732A1 (de) * 1998-04-27 1999-10-28 Bayer Ag Arylphenylsubstituierte cyclische Ketoenole
EP1406895B1 (fr) * 2001-06-13 2008-08-27 Magnachem International Laboratories, Inc. Formulation de lactone et procede d'utilisation
AU2003287546A1 (en) * 2002-11-05 2004-06-07 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
ES2214130B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 2-3'-bipiridinas.
ES2214129B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 3-fenilfuran-2-onas.
ES2213485B1 (es) * 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
WO2005102315A1 (fr) * 2004-04-23 2005-11-03 Magnachem International Laboratories, Inc. Formulations de lactone synthetique pour maitrise la douleur
EP1916240A1 (fr) * 2006-10-25 2008-04-30 Syngeta Participations AG Nouveaux derivés de pyridazine
AU2009308423B2 (en) * 2008-10-24 2013-08-29 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with Rad9
US9085544B2 (en) 2010-08-18 2015-07-21 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
US9630938B2 (en) 2010-08-18 2017-04-25 Delmar Pharmaceuticals, Inc. Method of synthesis of substituted hexitols such as dianhydrogalactitol
US8921585B2 (en) 2010-08-18 2014-12-30 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
AU2011292045B2 (en) * 2010-08-18 2016-03-24 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
JP2012087113A (ja) * 2010-09-22 2012-05-10 Daicel Corp フェニル酢酸化合物
MX377151B (es) 2013-12-24 2025-03-07 Us Dept Veterans Affairs Usos de sulfatos de colesterol oxigenados (soc).
US11083706B2 (en) 2016-07-21 2021-08-10 Conopco, Inc. Lactams for use in the treatment of skin lesions
WO2018015280A1 (fr) 2016-07-21 2018-01-25 Unilever Plc 4-(4-chlorophényl)-5-méthylène-pyrrol-2-one et 5-méthylène-4-(p-tolyl)pyrrol-2-one destinées à être utilisées dans le traitement d'infections bactériennes gram-négatives
CN109475526A (zh) 2016-07-21 2019-03-15 荷兰联合利华有限公司 用于治疗呼吸道感染的内酰胺
CN107056733B (zh) * 2017-03-24 2019-09-03 中国药科大学 具有抗癌活性的3－o－（对甲磺酸酯苯甲基）抗坏血酸及制备方法
US11191752B2 (en) 2017-04-28 2021-12-07 Case Western Reserve University Compounds and methods of treating retinal degeneration
CN110526844B (zh) * 2018-05-25 2021-11-12 江苏中旗科技股份有限公司 一种苯唑草酮中间体2,3-二甲基苯甲硫醚的合成方法
CN115925597A (zh) * 2022-12-20 2023-04-07 黄冈鲁班药业股份有限公司 双(4-磺酸基苯基)二硫化物的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE895151C (de) * 1951-07-29 1953-11-02 Robert Dr Pfleger Verfahren zur Herstellung von Chlormethylsulfiden
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
GB9615867D0 (en) * 1996-07-03 1996-09-11 Merck & Co Inc Process of preparing phenyl heterocycles useful as cox-2 inhibitors
ES2201466T3 (es) * 1997-03-14 2004-03-16 MERCK FROSST CANADA & CO. `(metilsulfonil)fenil-2-(5h)-furanonas con enlace con oxigeno como inhibidores de cox-2`.
WO1999023087A1 (fr) * 1997-10-30 1999-05-14 Merck Frosst Canada & Co. Diaryl-5-alkyl-5-methyl-2(5h)-furanones utilisees en tant qu'inhibiteurs selectifs de cyclo-oxygenase-2
TNSN99111A1 (fr) * 1998-06-11 2005-11-10 Pfizer Derives de sulfonylbenzene nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.
SK286314B6 (en) * 1999-04-14 2008-07-07 Pacific Corp 4,5-Diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors

Also Published As

Publication number Publication date
MXPA03000161A (es) 2004-02-26
US6686390B2 (en) 2004-02-03
WO2001090097A2 (fr) 2001-11-29
CA2412651A1 (fr) 2001-11-29
CN1443180A (zh) 2003-09-17
US20020032230A1 (en) 2002-03-14
WO2001090097A3 (fr) 2002-04-04

Similar Documents

Publication Publication Date Title
AU2001258677A1 (en) Novel compounds having antiinflammatory activity: process for their preparation and pharmaceutical compositions containing them
HUP0103376A3 (en) New 3-aryl-2-hydroxypropionic acid derivative, pharmaceutical compositions containing it, process for their preparation and their use
HUP0301187A3 (en) Novel benzyl-piperidine-derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0302519A3 (en) Crystalline forms of atorvastatin, process for their preparation and pharmaceutical compositions containing them
HUP0204245A3 (en) Novel n-azabicyclo-amide derivatives, process for their preparation, pharmaceutical compositions containing them and their use
HUP0301069A3 (en) Novel biarylcarboxamides, process for their preparation, pharmaceutical compositions containing them and their use
HUP0204496A3 (en) Novel piperidine compounds and pharmaceutical compositions containing the same and process for preparation the same
AU4949800A (en) 2-arylpurine-9-acetamide derivatives, process for the preparation thereof, medicinal compositions containing the same and intermediates of the derivatives
HUP0203183A3 (en) Novel heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use
HUP0105108A3 (en) Amide compounds, process for their preparation and pharmaceutical compositions containing them
AU2001295939A1 (en) Process for preparation of polyisocyanate composition
AP2002002575A0 (en) Compounds having hypolupedemic and hypocholestermic activities process for their preparation and pharmaceutical compositions containing them
HUP0201402A3 (en) Bis-sulfonamides, process for their preparation and pharmaceutical compositions containing them
HUP0204347A3 (en) Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them and their use
AU2841199A (en) Novel bis-benzamide derivatives, method for making same pharmaceutical compositions containing them and use thereof as medicine
HUP0100489A3 (en) New piperidine-4-sulphonamide compounds, process for their preparation and pharmaceutical compositions containing them
AU2001256570A1 (en) Novel anticancer compounds: process for their preparation and pharmaceutical compositions containing them
HUP0203471A3 (en) Antithrombotic compound, process for their preparation, pharmaceutical compositions containing them and their use
HUP0302912A3 (en) Betha-thio-amino acids, process for their preparation and pharmaceutical compositions containing them
AU2003231920A1 (en) Antiinfectve compounds, process for their preparation and pharmaceutical compositions containing them
HUP0301254A3 (en) Novel compounds, process fo their preparation and pharmaceutical compositions containing them
HUP0204005A3 (en) Novel forms of pravastatin sodium, process for their preparation and pharmaceutical compositions containing them
AU2001256568A1 (en) New compounds having anticancer activity: process for their preparation and pharmaceutical compositions containing them
AU2002210632A1 (en) Novel aminotriazolone compounds, method for preparing same and pharmaceutical compositions containing same
HUP0202379A3 (en) New compounds, process for producing them and pharmaceutical compositions containing them