ATE551361T1 - Mutante des granulozytenkoloniestimulierenden faktors (g-csf) und chemisch konjugiertes polypeptid davon - Google Patents
Mutante des granulozytenkoloniestimulierenden faktors (g-csf) und chemisch konjugiertes polypeptid davonInfo
- Publication number
- ATE551361T1 ATE551361T1 AT06783354T AT06783354T ATE551361T1 AT E551361 T1 ATE551361 T1 AT E551361T1 AT 06783354 T AT06783354 T AT 06783354T AT 06783354 T AT06783354 T AT 06783354T AT E551361 T1 ATE551361 T1 AT E551361T1
- Authority
- AT
- Austria
- Prior art keywords
- csf
- residue
- mutant
- cysteine
- stimulating factor
- Prior art date
Links
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 title abstract 8
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 title abstract 8
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 238000001727 in vivo Methods 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 abstract 2
- 229920000249 biocompatible polymer Polymers 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 2
- 230000021615 conjugation Effects 0.000 abstract 2
- 235000018417 cysteine Nutrition 0.000 abstract 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 150000001413 amino acids Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020050065746A KR100735784B1 (ko) | 2005-07-20 | 2005-07-20 | 인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물 |
| PCT/KR2006/002841 WO2007011166A1 (en) | 2005-07-20 | 2006-07-19 | Mutant of granulocyte-colony stimulating factor(g-csf) and chemically conjugated polypeptide thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE551361T1 true ATE551361T1 (de) | 2012-04-15 |
Family
ID=37669016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06783354T ATE551361T1 (de) | 2005-07-20 | 2006-07-19 | Mutante des granulozytenkoloniestimulierenden faktors (g-csf) und chemisch konjugiertes polypeptid davon |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8841426B2 (de) |
| EP (2) | EP1919945B1 (de) |
| JP (1) | JP4782834B2 (de) |
| KR (1) | KR100735784B1 (de) |
| CN (2) | CN101213208A (de) |
| AT (1) | ATE551361T1 (de) |
| ES (2) | ES2428863T3 (de) |
| WO (1) | WO2007011166A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0605684D0 (en) * | 2006-03-21 | 2006-05-03 | Sicor Biotech Uab | Method For Purifying Granulocyte-Colony Stimulating Factor |
| WO2008147534A1 (en) * | 2007-05-22 | 2008-12-04 | Maxygen Holdings Ltd. | Method for the treatment of neutropenia by administration of a multi-pegylated granulocyte colony stimulating factor (g-csf) variant |
| WO2009116524A1 (ja) * | 2008-03-17 | 2009-09-24 | 独立行政法人理化学研究所 | 改変タンパク質 |
| EP2274325A4 (de) * | 2008-05-13 | 2011-05-25 | Nora Therapeutics Inc | Analoga von humanem g-csf und verfahren zur herstellung und anwendung davon |
| EP2318029B1 (de) * | 2008-07-23 | 2017-11-01 | Ambrx, Inc. | Modifizierte bovine g-csf-polypeptide und ihre verwendung |
| AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
| US20140187488A1 (en) | 2011-05-17 | 2014-07-03 | Bristol-Myers Squibb Company | Methods for maintaining pegylation of polypeptides |
| EP3694535B1 (de) * | 2017-10-11 | 2025-11-26 | Elanco US Inc. | Varianten des porzinen g-csf und ihre verwendungen |
| JP2021509805A (ja) * | 2017-12-27 | 2021-04-08 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 顆粒球コロニー刺激因子活性を示すポリペプチド |
| CN116334057B (zh) * | 2022-08-16 | 2024-07-19 | 北京理工大学 | 一种利用聚乙二醇马来酰亚胺衍生物构建的酶组装体及其制备方法和应用 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| EP0347041A3 (de) * | 1988-05-13 | 1990-11-22 | Amgen Inc. | Zusammensetzungen und Verfahren zur Behandlung oder Verhütung von Infektionen bei Tieren |
| GB8824591D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
| US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
| US5766897A (en) | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| JP3708151B2 (ja) * | 1994-12-15 | 2005-10-19 | 協和醗酵工業株式会社 | Ｐｅｇ化したヒト顆粒球コロニー刺激因子の定量法 |
| US6066318A (en) * | 1995-10-05 | 2000-05-23 | G.D. Searle & Co. | Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors |
| KR100230579B1 (ko) | 1997-04-23 | 1999-12-01 | 허영섭 | 과립구 콜로니 자극인자를 발현하는 재조합 미생물 및 그로부터 전기 재조합 단백질의 제조방법 |
| IL133974A0 (en) * | 1997-07-14 | 2001-04-30 | Bolder Biotechnology Inc | Derivatives of growth hormone and related proteins |
| US7153943B2 (en) * | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
| US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| KR100260350B1 (ko) * | 1998-02-09 | 2000-07-01 | 허영섭 | 과립구 콜로니 자극인자의 유도체 단백질을 생산하는 재조합 미생물 및 그로부터 전기 재조합 단백질의 제조방법 |
| NZ513077A (en) | 1999-01-14 | 2004-03-26 | Bolder Biotechnology Inc | Methods for making proteins containing free cysteine residues |
| EP2133098A1 (de) | 2000-01-10 | 2009-12-16 | Maxygen Holdings Ltd | G-CSF-Konjugate |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| AU2001238595A1 (en) * | 2000-02-22 | 2001-09-03 | Shearwater Corporation | N-maleimidyl polymer derivatives |
| US7557195B2 (en) * | 2002-03-20 | 2009-07-07 | Biopolymed, Inc. | Stoichiometric conjugates of biocompatible polymers at the unpaired cysteine residue of the wild-type G-CSF |
| JP4412461B2 (ja) * | 2002-11-20 | 2010-02-10 | 日油株式会社 | 修飾された生体関連物質、その製造方法および中間体 |
| KR20040083268A (ko) * | 2003-03-21 | 2004-10-01 | 한미약품 주식회사 | 안정성이 증가된 인간 과립구 콜로니 자극인자 융합체 및이의 제조방법 |
-
2005
- 2005-07-20 KR KR1020050065746A patent/KR100735784B1/ko not_active Expired - Lifetime
-
2006
- 2006-07-19 CN CNA2006800239675A patent/CN101213208A/zh active Pending
- 2006-07-19 US US11/995,968 patent/US8841426B2/en active Active
- 2006-07-19 CN CN2010106059142A patent/CN102153643B/zh active Active
- 2006-07-19 AT AT06783354T patent/ATE551361T1/de active
- 2006-07-19 JP JP2008522703A patent/JP4782834B2/ja active Active
- 2006-07-19 EP EP06783354A patent/EP1919945B1/de active Active
- 2006-07-19 ES ES09010623T patent/ES2428863T3/es active Active
- 2006-07-19 EP EP09010623.8A patent/EP2174951B1/de active Active
- 2006-07-19 ES ES06783354T patent/ES2381256T3/es active Active
- 2006-07-19 WO PCT/KR2006/002841 patent/WO2007011166A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070010817A (ko) | 2007-01-24 |
| EP1919945A1 (de) | 2008-05-14 |
| JP2009501789A (ja) | 2009-01-22 |
| US8841426B2 (en) | 2014-09-23 |
| EP2174951A2 (de) | 2010-04-14 |
| KR100735784B1 (ko) | 2007-07-06 |
| US20080200657A1 (en) | 2008-08-21 |
| CN102153643B (zh) | 2012-12-12 |
| ES2381256T3 (es) | 2012-05-24 |
| EP2174951A3 (de) | 2010-07-07 |
| CN101213208A (zh) | 2008-07-02 |
| JP4782834B2 (ja) | 2011-09-28 |
| ES2428863T3 (es) | 2013-11-12 |
| EP1919945A4 (de) | 2009-02-18 |
| CN102153643A (zh) | 2011-08-17 |
| WO2007011166A1 (en) | 2007-01-25 |
| EP1919945B1 (de) | 2012-03-28 |
| EP2174951B1 (de) | 2013-09-11 |
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