[go: up one dir, main page]

ATE473000T1 - DICHLOROACETATE ALONG WITH AN INOTROPIC DRUG FOR CARDIOPROTECTION - Google Patents

DICHLOROACETATE ALONG WITH AN INOTROPIC DRUG FOR CARDIOPROTECTION

Info

Publication number
ATE473000T1
ATE473000T1 AT04702767T AT04702767T ATE473000T1 AT E473000 T1 ATE473000 T1 AT E473000T1 AT 04702767 T AT04702767 T AT 04702767T AT 04702767 T AT04702767 T AT 04702767T AT E473000 T1 ATE473000 T1 AT E473000T1
Authority
AT
Austria
Prior art keywords
dichloroacetate
cardioprotection
along
inotropic drug
inotropic
Prior art date
Application number
AT04702767T
Other languages
German (de)
Inventor
Gary Lopaschuk
Ruth Collins-Nakai
Original Assignee
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Alberta filed Critical Univ Alberta
Application granted granted Critical
Publication of ATE473000T1 publication Critical patent/ATE473000T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides composition and methods for maintaining cardiac function by administering dichloroacetate (DCA) in combination with an inotrope.
AT04702767T 2004-01-16 2004-01-16 DICHLOROACETATE ALONG WITH AN INOTROPIC DRUG FOR CARDIOPROTECTION ATE473000T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2004/000662 WO2005077353A1 (en) 2004-01-16 2004-01-16 Dichloroacetate in combination with an inotrope for cardioprotection

Publications (1)

Publication Number Publication Date
ATE473000T1 true ATE473000T1 (en) 2010-07-15

Family

ID=34746643

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04702767T ATE473000T1 (en) 2004-01-16 2004-01-16 DICHLOROACETATE ALONG WITH AN INOTROPIC DRUG FOR CARDIOPROTECTION

Country Status (8)

Country Link
EP (1) EP1708692B1 (en)
JP (1) JP2007517853A (en)
CN (1) CN1925851A (en)
AT (1) ATE473000T1 (en)
AU (1) AU2004315552A1 (en)
CA (1) CA2489853A1 (en)
DE (1) DE602004028046D1 (en)
WO (1) WO2005077353A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060194878A1 (en) * 2002-10-07 2006-08-31 Lopaschuk Gary D Methods of cardioprotection using dichloroacetate in combination with an inotrope
RU2644305C1 (en) * 2017-01-20 2018-02-08 Федеральное государственное бюджетное образовательное учреждение высшего образования "Кубанский государственный медицинский университет" Министерства здравоохранения Российской Федерации, ФГБОУ ВО КубГМУ Минздрава России Method of hepatocytolisis reducing under conditions of liver partial vascular insulation in the experiment
CN111773204B (en) * 2019-04-03 2023-01-24 上海市浦东新区浦南医院 Application of sodium dichloroacetate in preparing medicine for treating vascular dementia
LT6874B (en) 2020-04-17 2021-12-10 Lietuvos sveikatos mokslų universitetas Use of a combination of valproic acid and dichloroacetate salts in the treatment of cancer
LT7129B (en) 2023-08-22 2025-03-25 Lietuvos sveikatos mokslų universitetas A COMBINATION OF SODIUM DICHLOROACETATE AND VALPROIC ACID SALTS FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS AND INFLAMMATORY DISEASES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2202397C (en) * 1994-10-17 2002-07-16 Peter W. Stacpoole Compositions comprising carbonate/bicarbonate buffered dichloroacetic acid and methods for treatment of metabolic and cardiovascular disorders
GB9410320D0 (en) * 1994-05-24 1994-07-13 Fisons Corp Novel therapeutic method
US6076528A (en) * 1996-05-09 2000-06-20 Cypros Pharmaceutical Corp. Injection of fructose-1,6-diphosphate (FDP) prior to coronary artery bypass grafting surgery
CA2305183C (en) * 1997-10-03 2008-09-23 The Governors Of The University Of Alberta Postsurgical treatment with dichloroacetate
US20040039055A1 (en) * 2002-06-20 2004-02-26 Lopaschuk Gary D. Dichloroacetate in combination with clinically high levels of cardioprotective or hemodynamic drugs
US6693133B1 (en) * 2002-10-07 2004-02-17 University Of Alberta Methods of cardioprotection using dichloroacetate in combination with an inotrope

Also Published As

Publication number Publication date
JP2007517853A (en) 2007-07-05
AU2004315552A1 (en) 2005-08-25
DE602004028046D1 (en) 2010-08-19
EP1708692A1 (en) 2006-10-11
WO2005077353A1 (en) 2005-08-25
WO2005077353A8 (en) 2005-12-15
EP1708692B1 (en) 2010-07-07
CA2489853A1 (en) 2005-07-16
CN1925851A (en) 2007-03-07

Similar Documents

Publication Publication Date Title
GB2465677B (en) Non-systemic delivery of satiogens for use in the treatment of obesity and/or diabetes
EA200802184A1 (en) PHARMACEUTICAL COMPOSITIONS WITH DPP IV INHIBITORS
IL244803A0 (en) Humanized anti-beta7 antibodies and uses therefore
EP2468776A3 (en) Anti-Robo4 antibodies and uses therefor
CL2008001373A1 (en) Compounds derived from substituted phenylamino-benzene; Preparation method; pharmaceutical composition; farm kit; and use of said compounds in the treatment of cancer.
ZA200701656B (en) Humanized anti-cment antagonists
WO2007044026A3 (en) Compositions comprising modified collagen and uses therefore
WO2008140493A3 (en) Anti-egfr family antibodies, bispecific anti-egfr family antibodies and methods of use thereof
DE602005015491D1 (en) MEDICAL DEVICE WITH EXPERIMENTAL NANOPOROUS COATINGS FOR TAXED THERAPY SURPLUS
ATE526987T1 (en) DR5 ANTIBODIES AND THEIR USE
CL2009001099A1 (en) Use of a human interleukin-2 mutein for the treatment and / or prevention of an autoimmune disease.
IL191824A0 (en) Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling
ATE495739T1 (en) PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING LEVODOPA AND CARBIDOPA
CL2007001710A1 (en) Substituted amino-pyrazolopyridine derivatives; Preparation method; pharmaceutical composition; and use in the treatment of diseases such as tumors, rheumatoid arthritis, diseases of deregulated vascular growth, among others.
WO2007061939A3 (en) Metabolite derivatives of the hdac inhibitor fk228
ATE482966T1 (en) METHOD FOR PRODUCING 7-ALPHA-ALKYLATED 19-NORSTEROIDS
DE602005021970D1 (en) USE OF PEPTIDE COMPOUNDS FOR THE TREATMENT OF PAIN BY BONE CANCER, CHEMOTHERAPY AND NUCLEOSIDE-RELATED PAIN
DE602005015841D1 (en) AROYL-O-PIPERIDINE DERIVATIVES FOR TREATING PROBLEMS ASSOCIATED WITH DIABETES
DE602004021435D1 (en) INJECTABLE COMPOSITION FOR THE TREATMENT OF CANCER
EP1869190A4 (en) GENETIC INTRODUCTION SYSTEM WITH DECORIN GEN AND PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT CONTAINING THE SYSTEM
MX337358B (en) Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof.
EP2488208A4 (en) COMPOUNDS WITH BONE TARGETED UNITS CONJUGATED PEPTIDES AND METHOD FOR THE PRODUCTION AND USE THEREOF
DE602005027400D1 (en) IL-22 FOR THE TREATMENT OF FATIBILITY, DIABETES, HYPERLIPIDEMIA, HYPERGLYKEMIA AND INSULIN RESISTANCE
WO2007030944A3 (en) Methods of cardioprotection using dichloroacetate in combination with an inotrope
ATE473000T1 (en) DICHLOROACETATE ALONG WITH AN INOTROPIC DRUG FOR CARDIOPROTECTION

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties