ATE338033T1 - Thiophen- und thiazolsulfonamide als antineoplastische mittel - Google Patents

Thiophen- und thiazolsulfonamide als antineoplastische mittel

Info

Publication number: ATE338033T1
Authority: AT; Austria
Prior art keywords: thiazolesulfonamides; thiophene; antineoplastic agents; antineoplastic; agents
Prior art date: 2001-10-25

Application number

AT02802117T

Other languages

English (en)

Inventor

Dios Alfonso Lilly S A De

Cora Sue Grossman

Philip Arthur Hipskind

Ho-Shen Lin

Karen Lynn Lobb

De Uralde Garmendia Beat Lopez

Jose Eduardo Lopez

Mary Margaret Mader

Michael Enrico Richett

Chaun Shih

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-25

Filing date

2002-10-15

Publication date

2006-09-15

2002-10-15 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2006-09-15 Application granted granted Critical

2006-09-15 Publication of ATE338033T1 publication Critical patent/ATE338033T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02802117T 2001-10-25 2002-10-15 Thiophen- und thiazolsulfonamide als antineoplastische mittel ATE338033T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US35201201P	2001-10-25	2001-10-25

Publications (1)

Publication Number	Publication Date
ATE338033T1 true ATE338033T1 (de)	2006-09-15

Family

ID=23383421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02802117T ATE338033T1 (de)	2001-10-25	2002-10-15	Thiophen- und thiazolsulfonamide als antineoplastische mittel

Country Status (33)

Country	Link
US (2)	US7084170B2 (de)
EP (1)	EP1442030B1 (de)
JP (1)	JP4464681B2 (de)
KR (1)	KR100913471B1 (de)
CN (1)	CN1298709C (de)
AR (1)	AR037248A1 (de)
AT (1)	ATE338033T1 (de)
AU (1)	AU2002334817B2 (de)
BR (1)	BR0212386A (de)
CA (1)	CA2463300C (de)
CY (1)	CY1106247T1 (de)
DE (1)	DE60214413T2 (de)
DK (1)	DK1442030T3 (de)
EA (1)	EA006081B1 (de)
EC (1)	ECSP045078A (de)
EG (1)	EG26021A (de)
ES (1)	ES2269816T3 (de)
HR (1)	HRP20040371B1 (de)
HU (1)	HUP0401638A3 (de)
IL (2)	IL160851A0 (de)
MX (1)	MXPA04003886A (de)
MY (1)	MY130718A (de)
NO (1)	NO20041316L (de)
NZ (1)	NZ531136A (de)
PE (1)	PE20030574A1 (de)
PL (1)	PL208083B1 (de)
PT (1)	PT1442030E (de)
SI (1)	SI1442030T1 (de)
SV (1)	SV2004001367A (de)
TW (1)	TWI281916B (de)
UA (1)	UA75716C2 (de)
WO (1)	WO2003035629A1 (de)
ZA (1)	ZA200403089B (de)

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PL395097A1 (pl) *	2001-06-11	2011-10-10	Vertex Pharmaceuticals (Canada) Incorporated	Sposób wytwarzania związku o wzorze A stanowiącego pochodną tiofenu
SE0102616D0 (sv) *	2001-07-25	2001-07-25	Astrazeneca Ab	Novel compounds
JP2005531608A (ja) *	2002-06-06	2005-10-20	スミスクライン・ビーチャム・コーポレイション	ＮＦ−κＢ阻害剤
ES2345438T3 (es) *	2002-12-10	2010-09-23	Virochem Pharma Inc.	Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus.
SE0300091D0 (sv) *	2003-01-15	2003-01-15	Astrazeneca Ab	Novel compounds
SE0300092D0 (sv) *	2003-01-15	2003-01-15	Astrazeneca Ab	Novel compounds
US20050085531A1 (en) *	2003-10-03	2005-04-21	Hodge Carl N.	Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
US8772269B2 (en)	2004-09-13	2014-07-08	Eisai R&D Management Co., Ltd.	Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030941A1 (ja) *	2004-09-13	2006-03-23	Eisai R & D Management Co., Ltd.	スルホンアミド含有化合物の血管新生阻害物質との併用
JP5134247B2 (ja) *	2004-09-13	2013-01-30	エーザイ・アール・アンド・ディー・マネジメント株式会社	スルホンアミド含有化合物の血管新生阻害物質との併用
US20090047278A1 (en)	2005-02-28	2009-02-19	Eisai R & D Management Co., Ltd.	Novel Combinational Use of Sulfonamide Compound
EP1862179A4 (de) *	2005-02-28	2010-12-15	Eisai R&D Man Co Ltd	Neue verwendung einer sulfonamid-verbindung in kombination mit einem angiogenese-hemmer
WO2006090927A1 (ja) *	2005-02-28	2006-08-31	Eisai R & D Management Co., Ltd.	スルホンアミド化合物の摂食亢進作用
EP2546246A3 (de)	2005-05-13	2013-04-24	Virochem Pharma Inc.	Verbindungen und Verfahren zur Behandlung oder Vorbeugung von Flavivirus-Infektionen
US7208506B2 (en) *	2005-07-07	2007-04-24	Hoffmann-La Roche Inc.	Heteroarylethenyl derivatives, their manufacture and use as pharmaceutical agents
US7625896B2 (en) *	2005-11-25	2009-12-01	Hoffman-La Roche Inc.	Pyridylsulfonamide derivatives
EP2015070A4 (de)	2006-04-20	2010-04-21	Eisai R&D Man Co Ltd	Neuer marker für empfindlichkeit gegenüber einer sulfonamidverbindung
US7939532B2 (en) *	2006-10-26	2011-05-10	Hoffmann-La Roche Inc.	Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
EA201101492A1 (ru)	2006-11-15	2012-09-28	Вирокем Фарма Инк.	Аналоги тиофена для лечения или предупреждения флавивирусных инфекций
EP2148861A1 (de)	2007-05-16	2010-02-03	F. Hoffmann-Roche AG	Arylpyridylsulfonamidderivate, ihre herstellung und verwendung als arzneimittel
CN101899008B (zh) *	2010-05-20	2012-10-17	中国人民解放军第二军医大学	N-取代嘧啶磺酰基-取代苯甲酰胺类化合物及其制备药物的用途
CN103450149B (zh) *	2012-06-01	2015-10-14	中国科学院上海有机化学研究所	苯基噻吩磺酰胺类化合物及其制备方法和用途
JP6364967B2 (ja) *	2014-05-30	2018-08-01	東ソー株式会社	ジチエノベンゾジチオフェンの製造方法
CN106588868A (zh) *	2016-11-16	2017-04-26	武汉理工大学	一种2‑溴‑3‑噻吩甲酸中间体的合成方法
CN108558822B (zh) *	2018-06-01	2020-12-18	盐城锦明药业有限公司	N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法
CN110835345A (zh) *	2018-08-17	2020-02-25	中国科学院上海药物研究所	一类细胞周期依赖性激酶的降解剂、其制备方法、药物组合物及其用途
CN109265437A (zh) *	2018-10-19	2019-01-25	凯莱英医药集团（天津）股份有限公司	一种3-羟基噻吩-2-羧酸酯类化合物的制备方法
WO2024251876A1 (en) *	2023-06-07	2024-12-12	KRæFTENS BEKæMPELSE	PROTACs AND HyT-PD MOLECULES FOR TARGETED PROTEIN DEGRADATION OF DCAF15 AND THEIR USE IN THE TREATMENT OF AMYLOIDOSIS
WO2025031361A1 (zh) *	2023-08-09	2025-02-13	上海科技大学	磺酰胺类化合物作为制备治疗癌症药物的用途

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ZA813332B (en) *	1980-06-21	1982-05-26	Pfizer	Larvicides and isecticides
NZ238911A (en) *	1990-07-17	1993-10-26	Lilly Co Eli	Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor
US5177074A (en) *	1991-03-26	1993-01-05	Merck & Co., Inc.	Angiotensin ii antagonists incorporating a substituted thiophene or furan
US5169860A (en) *	1992-03-13	1992-12-08	Eli Lilly And Company	Antitumor compositions and methods of treatment
EP1023284B1 (de) *	1996-07-05	2005-11-23	THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES	Gesättigte 1,2-dithiaheterocyclische verbindungen enthaltende antivirale pharmazeutische zubereitungen
EP0929540A4 (de) *	1996-10-04	2001-12-12	Lilly Co Eli	Antitumor-zusamensetzungen und behandlungsverfahren
JP4316787B2 (ja)	2000-01-11	2009-08-19	壽製薬株式会社	エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、

2002
- 2002-10-11 TW TW091123452A patent/TWI281916B/zh not_active IP Right Cessation
- 2002-10-15 MX MXPA04003886A patent/MXPA04003886A/es active IP Right Grant
- 2002-10-15 HR HRP20040371AA patent/HRP20040371B1/xx not_active IP Right Cessation
- 2002-10-15 KR KR1020047006058A patent/KR100913471B1/ko not_active Expired - Fee Related
- 2002-10-15 AU AU2002334817A patent/AU2002334817B2/en not_active Ceased
- 2002-10-15 CA CA2463300A patent/CA2463300C/en not_active Expired - Fee Related
- 2002-10-15 US US10/490,935 patent/US7084170B2/en not_active Expired - Fee Related
- 2002-10-15 UA UA20040403046A patent/UA75716C2/uk unknown
- 2002-10-15 HU HU0401638A patent/HUP0401638A3/hu unknown
- 2002-10-15 EP EP02802117A patent/EP1442030B1/de not_active Expired - Lifetime
- 2002-10-15 PL PL368234A patent/PL208083B1/pl not_active IP Right Cessation
- 2002-10-15 WO PCT/US2002/031568 patent/WO2003035629A1/en not_active Ceased
- 2002-10-15 JP JP2003538145A patent/JP4464681B2/ja not_active Expired - Fee Related
- 2002-10-15 BR BR0212386-0A patent/BR0212386A/pt not_active IP Right Cessation
- 2002-10-15 NZ NZ531136A patent/NZ531136A/en not_active IP Right Cessation
- 2002-10-15 SI SI200230399T patent/SI1442030T1/sl unknown
- 2002-10-15 EA EA200400582A patent/EA006081B1/ru not_active IP Right Cessation
- 2002-10-15 ES ES02802117T patent/ES2269816T3/es not_active Expired - Lifetime
- 2002-10-15 IL IL16085102A patent/IL160851A0/xx unknown
- 2002-10-15 DE DE60214413T patent/DE60214413T2/de not_active Expired - Lifetime
- 2002-10-15 PT PT02802117T patent/PT1442030E/pt unknown
- 2002-10-15 CN CNB028212150A patent/CN1298709C/zh not_active Expired - Fee Related
- 2002-10-15 AT AT02802117T patent/ATE338033T1/de active
- 2002-10-15 DK DK02802117T patent/DK1442030T3/da active
- 2002-10-21 EG EG2002101152A patent/EG26021A/en active
- 2002-10-23 MY MYPI20023959A patent/MY130718A/en unknown
- 2002-10-23 AR ARP020104007A patent/AR037248A1/es active IP Right Grant
- 2002-10-24 SV SV2002001367A patent/SV2004001367A/es unknown
- 2002-10-25 PE PE2002001051A patent/PE20030574A1/es not_active Application Discontinuation
2004
- 2004-03-11 IL IL160851A patent/IL160851A/en not_active IP Right Cessation
- 2004-03-30 NO NO20041316A patent/NO20041316L/no not_active Application Discontinuation
- 2004-04-22 ZA ZA200403089A patent/ZA200403089B/en unknown
- 2004-04-23 EC EC2004005078A patent/ECSP045078A/es unknown
2006
- 2006-06-06 US US11/447,457 patent/US7250430B2/en not_active Expired - Fee Related
- 2006-11-16 CY CY20061101669T patent/CY1106247T1/el unknown

Also Published As

Publication number	Publication date
MXPA04003886A (es)	2004-07-08
EP1442030B1 (de)	2006-08-30
IL160851A0 (en)	2004-08-31
IL160851A (en)	2009-11-18
EA200400582A1 (ru)	2004-08-26
DE60214413T2 (de)	2007-03-08
MY130718A (en)	2007-07-31
SI1442030T1 (sl)	2006-12-31
JP4464681B2 (ja)	2010-05-19
TWI281916B (en)	2007-06-01
AU2002334817B2 (en)	2008-02-21
WO2003035629A1 (en)	2003-05-01
HK1068337A1 (en)	2005-04-29
UA75716C2 (en)	2006-05-15
EP1442030A1 (de)	2004-08-04
US20060223871A1 (en)	2006-10-05
EA006081B1 (ru)	2005-08-25
DK1442030T3 (da)	2006-12-27
HUP0401638A3 (en)	2012-09-28
EG26021A (en)	2012-12-10
US20040198784A1 (en)	2004-10-07
ECSP045078A (es)	2004-06-28
HRP20040371B1 (en)	2012-07-31
NZ531136A (en)	2006-08-31
CN1575286A (zh)	2005-02-02
HUP0401638A2 (hu)	2004-11-29
AR037248A1 (es)	2004-11-03
ES2269816T3 (es)	2007-04-01
US7250430B2 (en)	2007-07-31
CA2463300A1 (en)	2003-05-01
CN1298709C (zh)	2007-02-07
PL368234A1 (en)	2005-03-21
KR100913471B1 (ko)	2009-08-25
KR20040062583A (ko)	2004-07-07
PL208083B1 (pl)	2011-03-31
PT1442030E (pt)	2006-12-29
CY1106247T1 (el)	2011-06-08
BR0212386A (pt)	2004-07-27
CA2463300C (en)	2011-07-19
US7084170B2 (en)	2006-08-01
NO20041316L (no)	2004-03-30
HRP20040371A2 (en)	2004-08-31
DE60214413D1 (de)	2006-10-12
SV2004001367A (es)	2004-02-24
PE20030574A1 (es)	2003-07-03
ZA200403089B (en)	2005-04-22
JP2005511547A (ja)	2005-04-28

Publication	Publication Date	Title
ATE338033T1 (de)	2006-09-15	Thiophen- und thiazolsulfonamide als antineoplastische mittel
ATE391531T1 (de)	2008-04-15	Schweisshemmende mittel
ATE392898T1 (de)	2008-05-15	Antiphlogistische mittel
DE60106275D1 (de)	2004-11-11	Dermatologisches mittel
EP1298180A4 (de)	2005-03-09	Hydrophobe und lipophobe zusammensetzung
DE60234652D1 (de)	2010-01-14	Verschleissteil und -anordnung
DE60233227D1 (de)	2009-09-17	Thiophenderivate als antivirale mittel gegen flavivirus-infektion
ATE516030T1 (de)	2011-07-15	Benzimidazolidinon-derivate als muscarinische mittel
ATE550940T1 (de)	2012-04-15	Synergische herbizide mittel
DE60133831D1 (de)	2008-06-12	Verwendung von cci-779 als antineoplastisches mittel
DE60204770D1 (de)	2005-07-28	Scharnier
DE60207318D1 (de)	2005-12-22	Festes kosmetisches Mittel
DE60230470D1 (de)	2009-02-05	Festes kosmetisches Mittel
DE60220505D1 (de)	2007-07-19	Haarwaschmittel
ATE343394T1 (de)	2006-11-15	Endoparasitizide mittel
DE60220799D1 (de)	2007-08-02	Hypoglykämisches mittel
ATE321761T1 (de)	2006-04-15	Indolylpiperidinderivate als antihistaminische und antiallergische mittel
FI20001551A0 (fi)	2000-06-29	Saranat
DK1392670T3 (da)	2005-08-08	Substituerede C-furan-2-yl-methylamin- og C-thiophen-2-yl-methylamin-derivater
DE60136966D1 (de)	2009-01-22	Pflanzenstärkendes mittel
ATE287708T1 (de)	2005-02-15	1-amino-alkylcyclohexanederivate als trypanocide mittel
EP1701736A4 (de)	2008-05-07	Therapeutische mittel und ihre verwendungen
DE60219418T8 (de)	2008-04-30	Silanylphenole und -naphthole
DE60235139D1 (de)	2010-03-11	Recheneinheit und Empfangseinheit
NO20021957L (no)	2002-10-28	Hengsel

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