ATE336991T1 - Bis(thio-hydrazid amid) verbindungen zur behandlung von mehrfach resistenten krebs - Google Patents
Bis(thio-hydrazid amid) verbindungen zur behandlung von mehrfach resistenten krebsInfo
- Publication number
- ATE336991T1 ATE336991T1 AT04702560T AT04702560T ATE336991T1 AT E336991 T1 ATE336991 T1 AT E336991T1 AT 04702560 T AT04702560 T AT 04702560T AT 04702560 T AT04702560 T AT 04702560T AT E336991 T1 ATE336991 T1 AT E336991T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- group
- aryl group
- bonded
- taken together
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000016691 refractory malignant neoplasm Diseases 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44040603P | 2003-01-15 | 2003-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE336991T1 true ATE336991T1 (de) | 2006-09-15 |
Family
ID=32771813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04702560T ATE336991T1 (de) | 2003-01-15 | 2004-01-15 | Bis(thio-hydrazid amid) verbindungen zur behandlung von mehrfach resistenten krebs |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7763658B2 (de) |
| EP (1) | EP1583524B1 (de) |
| JP (1) | JP4852409B2 (de) |
| AT (1) | ATE336991T1 (de) |
| AU (1) | AU2004206865B2 (de) |
| CA (1) | CA2512797C (de) |
| CY (1) | CY1106246T1 (de) |
| DE (1) | DE602004002087T2 (de) |
| DK (1) | DK1583524T3 (de) |
| ES (1) | ES2271839T3 (de) |
| PT (1) | PT1583524E (de) |
| TW (1) | TWI330079B (de) |
| WO (1) | WO2004064826A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| WO2005094322A2 (en) | 2004-03-29 | 2005-10-13 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| ES2430373T3 (es) * | 2004-06-23 | 2013-11-20 | Synta Pharmaceuticals Corp. | Sales de bis(tio-hidrazida amida) para tratamiento de cánceres |
| US20060142393A1 (en) * | 2004-09-16 | 2006-06-29 | Sherman Matthew L | Bis(thio-hydrazide amides) for treatment of hyperplasia |
| US20060167106A1 (en) * | 2004-11-19 | 2006-07-27 | Mei Zhang | Compounds acting at the centrosome |
| AU2005306471B2 (en) * | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| WO2006113695A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| AU2006236534A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
| NZ563124A (en) | 2005-05-16 | 2010-12-24 | Synta Pharmaceuticals Corp | Synthesis of bis(thio-hydrazide amide) salts |
| JP2009504740A (ja) * | 2005-08-16 | 2009-02-05 | シンタ ファーマシューティカルズ コーポレーション | ビス（チオ−ヒドラジドアミド）製剤 |
| JP2010501559A (ja) * | 2006-08-21 | 2010-01-21 | シンタ ファーマシューティカルズ コーポレーション | 黒色腫の再発を予防するまたは遅らせるのに使用するためのビス（チオヒドラジドアミド） |
| WO2008024298A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
| WO2008024303A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| AU2007288337B2 (en) | 2006-08-21 | 2012-02-16 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US20100068174A1 (en) * | 2006-08-21 | 2010-03-18 | Synta Pharmaceuticals Corp. | Combination with bis (thiohydrazide amides) for treating cancer |
| EP2061451A2 (de) * | 2006-08-21 | 2009-05-27 | Synta Pharmaceuticals Corporation | Bis(thiohydrazidamide) für melanombehandlung |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| EP2076254A2 (de) * | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Kombination mit bis(thiohydrazidamiden) zur behandlung von krebs |
| EP2061430A2 (de) * | 2006-09-11 | 2009-05-27 | Synta Pharmaceuticals Corporation | Bi-(thiohydrazidamid)-formulierung |
| US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
| US7645904B2 (en) | 2006-09-15 | 2010-01-12 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| US8618170B2 (en) * | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
| WO2009073148A2 (en) * | 2007-11-28 | 2009-06-11 | Synta Pharmaceuticals Corp. | Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide) |
| US8581004B2 (en) | 2008-02-21 | 2013-11-12 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| WO2009123704A2 (en) * | 2008-03-31 | 2009-10-08 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
| WO2010048284A1 (en) | 2008-10-22 | 2010-04-29 | Synta Pharmaceuticals Corp. | Transition metal complexes of bis[thiohydrazide amide] compounds |
| JP2012506444A (ja) * | 2008-10-22 | 2012-03-15 | シンタ ファーマシューティカルズ コーポレーション | ビス［チオヒドラジドアミド］化合物の遷移金属錯体 |
| US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
| JP5631327B2 (ja) | 2008-12-01 | 2014-11-26 | シンタ ファーマシューティカルズ コーポレーション | 増殖性障害を治療するための化合物 |
| WO2011069159A2 (en) | 2009-12-04 | 2011-06-09 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
| US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
| EP2776021A1 (de) * | 2011-11-10 | 2014-09-17 | Synta Pharmaceuticals Corp. | Verabreichung einer bis(thiohydrazidamid)verbindung zur behandlung von krebs |
| US20130149392A1 (en) | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| WO2018023017A1 (en) | 2016-07-29 | 2018-02-01 | Janssen Pharmaceutica Nv | Methods of treating prostate cancer |
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| US6602907B1 (en) | 2001-06-08 | 2003-08-05 | University Of Central Florida | Treatment of breast cancer |
| TWI252847B (en) | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
| TWI297335B (en) * | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
| US6924312B2 (en) | 2001-07-10 | 2005-08-02 | Synta Pharmaceuticals Corp. | Taxol enhancer compounds |
| TWI332943B (en) | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
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| AU2006228035B2 (en) | 2003-01-15 | 2010-02-18 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
| EA009919B1 (ru) | 2003-02-11 | 2008-04-28 | Вернэлис (Кембридж) Лимитед | Соединения изоксазола |
| KR100575251B1 (ko) | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | ｐ38／ＪＴＶ－1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법 |
| EP1493445A1 (de) | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibierung von Stress-induzierter Liganden-abhängiger EGFR Aktivierung |
| TWI339206B (en) | 2003-09-04 | 2011-03-21 | Vertex Pharma | Compositions useful as inhibitors of protein kinases |
| KR100544347B1 (ko) | 2003-12-11 | 2006-01-23 | 한국생명공학연구원 | 디아릴이소옥사졸계 화합물을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물 |
| AU2005230867A1 (en) | 2004-03-26 | 2005-10-20 | Amphora Discovery Corporation | Certain triazole-based compounds, compositions, and uses thereof |
| ES2430373T3 (es) | 2004-06-23 | 2013-11-20 | Synta Pharmaceuticals Corp. | Sales de bis(tio-hidrazida amida) para tratamiento de cánceres |
| US20060142393A1 (en) | 2004-09-16 | 2006-06-29 | Sherman Matthew L | Bis(thio-hydrazide amides) for treatment of hyperplasia |
| AU2005306471B2 (en) | 2004-11-19 | 2009-12-17 | Synta Pharmaceuticals Corp. | Bis(thio-hydrazide amides) for increasing Hsp70 expression |
| US20060167106A1 (en) | 2004-11-19 | 2006-07-27 | Mei Zhang | Compounds acting at the centrosome |
| CN101142198B (zh) | 2005-02-17 | 2012-10-31 | 辛塔制药公司 | 用于治疗疾病的异*唑坎布雷它斯丁衍生物 |
| WO2006113695A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
| WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
| AU2006236534A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
| NZ563124A (en) | 2005-05-16 | 2010-12-24 | Synta Pharmaceuticals Corp | Synthesis of bis(thio-hydrazide amide) salts |
| JP2009504740A (ja) | 2005-08-16 | 2009-02-05 | シンタ ファーマシューティカルズ コーポレーション | ビス（チオ−ヒドラジドアミド）製剤 |
| CA2653222A1 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| AU2007288337B2 (en) | 2006-08-21 | 2012-02-16 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| US20100068174A1 (en) | 2006-08-21 | 2010-03-18 | Synta Pharmaceuticals Corp. | Combination with bis (thiohydrazide amides) for treating cancer |
| EP2061451A2 (de) | 2006-08-21 | 2009-05-27 | Synta Pharmaceuticals Corporation | Bis(thiohydrazidamide) für melanombehandlung |
| WO2008024303A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
| JP2010501559A (ja) | 2006-08-21 | 2010-01-21 | シンタ ファーマシューティカルズ コーポレーション | 黒色腫の再発を予防するまたは遅らせるのに使用するためのビス（チオヒドラジドアミド） |
| WO2008024298A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
| EP2076254A2 (de) | 2006-08-31 | 2009-07-08 | Synta Pharmaceuticals Corporation | Kombination mit bis(thiohydrazidamiden) zur behandlung von krebs |
| EP2061430A2 (de) | 2006-09-11 | 2009-05-27 | Synta Pharmaceuticals Corporation | Bi-(thiohydrazidamid)-formulierung |
| AU2007294752A1 (en) | 2006-09-14 | 2008-03-20 | Synta Pharmaceuticals Corp. | Compounds for the treatment of angiogenesis |
| US7645904B2 (en) | 2006-09-15 | 2010-01-12 | Synta Pharmaceuticals Corp. | Purification of bis(thiohydrazide amides) |
| WO2008082579A1 (en) | 2007-01-03 | 2008-07-10 | Synta Pharmaceuticals Corp. | Method for treating cancer |
| TW200922550A (en) | 2007-08-07 | 2009-06-01 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
-
2004
- 2004-01-14 TW TW093100878A patent/TWI330079B/zh not_active IP Right Cessation
- 2004-01-15 EP EP04702560A patent/EP1583524B1/de not_active Expired - Lifetime
- 2004-01-15 ES ES04702560T patent/ES2271839T3/es not_active Expired - Lifetime
- 2004-01-15 PT PT04702560T patent/PT1583524E/pt unknown
- 2004-01-15 DE DE602004002087T patent/DE602004002087T2/de not_active Expired - Lifetime
- 2004-01-15 DK DK04702560T patent/DK1583524T3/da active
- 2004-01-15 JP JP2006500976A patent/JP4852409B2/ja not_active Expired - Fee Related
- 2004-01-15 US US10/758,589 patent/US7763658B2/en not_active Expired - Fee Related
- 2004-01-15 CA CA2512797A patent/CA2512797C/en not_active Expired - Fee Related
- 2004-01-15 AT AT04702560T patent/ATE336991T1/de active
- 2004-01-15 AU AU2004206865A patent/AU2004206865B2/en not_active Ceased
- 2004-01-15 WO PCT/US2004/001089 patent/WO2004064826A1/en not_active Ceased
-
2006
- 2006-11-16 CY CY20061101668T patent/CY1106246T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1583524E (pt) | 2006-12-29 |
| US7763658B2 (en) | 2010-07-27 |
| US20040225016A1 (en) | 2004-11-11 |
| DK1583524T3 (da) | 2006-12-27 |
| EP1583524A1 (de) | 2005-10-12 |
| TWI330079B (en) | 2010-09-11 |
| TW200418449A (en) | 2004-10-01 |
| CA2512797A1 (en) | 2004-08-05 |
| DE602004002087D1 (de) | 2006-10-05 |
| AU2004206865A1 (en) | 2004-08-05 |
| WO2004064826A1 (en) | 2004-08-05 |
| DE602004002087T2 (de) | 2007-03-08 |
| HK1084024A1 (en) | 2006-07-21 |
| JP2006515626A (ja) | 2006-06-01 |
| CY1106246T1 (el) | 2011-06-08 |
| EP1583524B1 (de) | 2006-08-23 |
| JP4852409B2 (ja) | 2012-01-11 |
| CA2512797C (en) | 2012-02-21 |
| AU2004206865B2 (en) | 2006-07-13 |
| ES2271839T3 (es) | 2007-04-16 |
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