ATE398130T1 - Diaminopyrroloquinazoline als protein tyrosine phosphatase inhibitoren - Google Patents
Diaminopyrroloquinazoline als protein tyrosine phosphatase inhibitorenInfo
- Publication number
- ATE398130T1 ATE398130T1 AT04731898T AT04731898T ATE398130T1 AT E398130 T1 ATE398130 T1 AT E398130T1 AT 04731898 T AT04731898 T AT 04731898T AT 04731898 T AT04731898 T AT 04731898T AT E398130 T1 ATE398130 T1 AT E398130T1
- Authority
- AT
- Austria
- Prior art keywords
- diaminopyrroloquinazoline
- protein tyrosine
- tyrosine phosphatase
- phosphatase inhibitors
- useful
- Prior art date
Links
- WJIPXHXGFHECTD-UHFFFAOYSA-N C1=CC2=NC=CC2=C2NC(N)=NC(N)=C21 Chemical compound C1=CC2=NC=CC2=C2NC(N)=NC(N)=C21 WJIPXHXGFHECTD-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003806 protein tyrosine phosphatase inhibitor Substances 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 101001087394 Homo sapiens Tyrosine-protein phosphatase non-receptor type 1 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 abstract 1
- 102100033001 Tyrosine-protein phosphatase non-receptor type 1 Human genes 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 108020000494 protein-tyrosine phosphatase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47078003P | 2003-05-15 | 2003-05-15 | |
| US56276304P | 2004-04-16 | 2004-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE398130T1 true ATE398130T1 (de) | 2008-07-15 |
Family
ID=33457197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04731898T ATE398130T1 (de) | 2003-05-15 | 2004-05-10 | Diaminopyrroloquinazoline als protein tyrosine phosphatase inhibitoren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7226915B2 (de) |
| EP (1) | EP1633754B1 (de) |
| JP (1) | JP4477010B2 (de) |
| KR (1) | KR100755579B1 (de) |
| AT (1) | ATE398130T1 (de) |
| AU (1) | AU2004238515B2 (de) |
| BR (1) | BRPI0410390A (de) |
| CA (1) | CA2524709C (de) |
| DE (1) | DE602004014370D1 (de) |
| ES (1) | ES2309518T3 (de) |
| MX (1) | MXPA05012208A (de) |
| PL (1) | PL1633754T3 (de) |
| RU (1) | RU2367664C2 (de) |
| WO (1) | WO2004101569A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7262297B2 (en) * | 2003-05-15 | 2007-08-28 | Hoffmann-La Roche Inc. | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors |
| US7322412B2 (en) * | 2004-08-30 | 2008-01-29 | Halliburton Energy Services, Inc. | Casing shoes and methods of reverse-circulation cementing of casing |
| US8835445B2 (en) | 2010-06-02 | 2014-09-16 | Trius Therapeutics, Inc. | Dihydrofolate reductase inhibitors |
| WO2024123585A1 (en) * | 2022-12-05 | 2024-06-13 | Merck Sharp & Dohme Llc | Substituted quinazoline derivatives and methods of use thereof |
| WO2025253326A1 (ko) * | 2024-06-05 | 2025-12-11 | 에스케이바이오팜 주식회사 | Kras 저해제로서 신규한 3환 화합물 및 이의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4118561A (en) * | 1977-04-06 | 1978-10-03 | American Home Products Corporation | 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines |
| US4208520A (en) * | 1978-06-28 | 1980-06-17 | American Home Products Corporation | 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines |
| US4233445A (en) * | 1979-07-05 | 1980-11-11 | American Home Products Corporation | 7-(Substituted)-7H-pyrrolo[3.2-F]-quinazoline-1,3-diamines |
| US4288595A (en) * | 1980-04-24 | 1981-09-08 | American Home Products Corporation | 7-(Substituted)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamines |
| HU225047B1 (en) * | 1991-03-28 | 2006-05-29 | Eisai Co Ltd | Heterocyclic-piperidin-derivatives, pharmaceutical compositions containing them and process for their production |
| GB9123916D0 (en) | 1991-11-11 | 1992-01-02 | Wellcome Found | Heterocyclic compounds |
| AU3791699A (en) | 1998-05-12 | 1999-11-29 | American Home Products Corporation | Naphtho{2,3-b}heteroar-4-yl derivatives |
| US6740657B2 (en) * | 2001-02-23 | 2004-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists |
| DE10108752A1 (de) | 2001-02-23 | 2002-09-05 | Bayer Ag | Neue Substituierte Imidazotriazinone |
-
2004
- 2004-04-30 US US10/835,713 patent/US7226915B2/en not_active Expired - Fee Related
- 2004-05-10 DE DE602004014370T patent/DE602004014370D1/de not_active Expired - Lifetime
- 2004-05-10 RU RU2005138895/04A patent/RU2367664C2/ru not_active IP Right Cessation
- 2004-05-10 EP EP04731898A patent/EP1633754B1/de not_active Expired - Lifetime
- 2004-05-10 JP JP2006529772A patent/JP4477010B2/ja not_active Expired - Lifetime
- 2004-05-10 MX MXPA05012208A patent/MXPA05012208A/es active IP Right Grant
- 2004-05-10 ES ES04731898T patent/ES2309518T3/es not_active Expired - Lifetime
- 2004-05-10 CA CA002524709A patent/CA2524709C/en not_active Expired - Fee Related
- 2004-05-10 PL PL04731898T patent/PL1633754T3/pl unknown
- 2004-05-10 BR BRPI0410390-4A patent/BRPI0410390A/pt not_active IP Right Cessation
- 2004-05-10 WO PCT/EP2004/004978 patent/WO2004101569A1/en not_active Ceased
- 2004-05-10 AT AT04731898T patent/ATE398130T1/de active
- 2004-05-10 KR KR1020057021778A patent/KR100755579B1/ko not_active Expired - Fee Related
- 2004-05-10 AU AU2004238515A patent/AU2004238515B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| RU2367664C2 (ru) | 2009-09-20 |
| WO2004101569A1 (en) | 2004-11-25 |
| EP1633754A1 (de) | 2006-03-15 |
| CA2524709C (en) | 2009-09-15 |
| PL1633754T3 (pl) | 2008-11-28 |
| AU2004238515A1 (en) | 2004-11-25 |
| DE602004014370D1 (de) | 2008-07-24 |
| BRPI0410390A (pt) | 2006-07-18 |
| RU2005138895A (ru) | 2007-06-27 |
| KR20060011874A (ko) | 2006-02-03 |
| US7226915B2 (en) | 2007-06-05 |
| JP2006528945A (ja) | 2006-12-28 |
| JP4477010B2 (ja) | 2010-06-09 |
| US20040229890A1 (en) | 2004-11-18 |
| ES2309518T3 (es) | 2008-12-16 |
| MXPA05012208A (es) | 2006-02-08 |
| KR100755579B1 (ko) | 2007-09-06 |
| EP1633754B1 (de) | 2008-06-11 |
| CA2524709A1 (en) | 2004-11-25 |
| AU2004238515B2 (en) | 2008-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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