[go: up one dir, main page]

ATE527264T1 - Kondensierte heterozyklische verbindungen als hemmer von proteinkinasen - Google Patents

Kondensierte heterozyklische verbindungen als hemmer von proteinkinasen

Info

Publication number
ATE527264T1
ATE527264T1 AT08780617T AT08780617T ATE527264T1 AT E527264 T1 ATE527264 T1 AT E527264T1 AT 08780617 T AT08780617 T AT 08780617T AT 08780617 T AT08780617 T AT 08780617T AT E527264 T1 ATE527264 T1 AT E527264T1
Authority
AT
Austria
Prior art keywords
inhibitors
heterocyclic compounds
protein kinases
condensed heterocyclic
compounds
Prior art date
Application number
AT08780617T
Other languages
English (en)
Inventor
Michael MICHAELIDES
Zhiqin Ji
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE527264T1 publication Critical patent/ATE527264T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT08780617T 2007-05-09 2008-05-09 Kondensierte heterozyklische verbindungen als hemmer von proteinkinasen ATE527264T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91684607P 2007-05-09 2007-05-09
US91683807P 2007-05-09 2007-05-09
PCT/US2008/063197 WO2008141145A1 (en) 2007-05-09 2008-05-09 Condensed heterocyclic compounds as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
ATE527264T1 true ATE527264T1 (de) 2011-10-15

Family

ID=39650562

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08780617T ATE527264T1 (de) 2007-05-09 2008-05-09 Kondensierte heterozyklische verbindungen als hemmer von proteinkinasen

Country Status (8)

Country Link
EP (1) EP2150553B1 (de)
JP (1) JP5412424B2 (de)
CN (1) CN101730700A (de)
AT (1) ATE527264T1 (de)
CA (1) CA2685351A1 (de)
ES (1) ES2372559T3 (de)
MX (1) MX2009012079A (de)
WO (1) WO2008141145A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8624027B2 (en) 2005-05-12 2014-01-07 Abbvie Inc. Combination therapy for treating cancer and diagnostic assays for use therein
US8124759B2 (en) 2007-05-09 2012-02-28 Abbott Laboratories Inhibitors of protein kinases
CN102532042A (zh) * 2010-12-30 2012-07-04 上海医药工业研究院 一种芳基脲类化合物、其中间体及其应用
KR20150061651A (ko) * 2012-09-26 2015-06-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ire1의 조절

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0415395A (pt) * 2003-10-15 2006-12-12 Osi Pharm Inc composto, métodos para inibir a atividade da proteìna quinase e para tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase, e, composição
AR048518A1 (es) * 2004-04-02 2006-05-03 Osi Pharm Inc Inhibidores heterobiciclicos de proteina quinasas sustituidos con anillos 6,6 -biciclicos
US7776865B2 (en) * 2005-10-06 2010-08-17 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
CA2630271C (en) * 2005-11-17 2014-04-08 Osi Pharmaceuticals, Inc. Fused bicyclic mtor inhibitors
AR057960A1 (es) * 2005-12-02 2007-12-26 Osi Pharm Inc Inhibidores de proteina quinasa biciclicos
WO2007087395A2 (en) * 2006-01-25 2007-08-02 Osi Pharmaceuticals, Inc. UNSATURATED mTOR INHIBITORS
EP1996193A2 (de) * 2006-03-13 2008-12-03 OSI Pharmaceuticals, Inc. Kombinierte behandlung mit einem egfr-kinase-hemmber und einem wirkstoff, der tumorzellen für die wirkung von egfr-kinase-hemmern sensibilisiert

Also Published As

Publication number Publication date
CA2685351A1 (en) 2008-11-20
MX2009012079A (es) 2009-11-19
JP5412424B2 (ja) 2014-02-12
JP2010526833A (ja) 2010-08-05
EP2150553B1 (de) 2011-10-05
EP2150553A1 (de) 2010-02-10
ES2372559T3 (es) 2012-01-23
CN101730700A (zh) 2010-06-09
WO2008141145A1 (en) 2008-11-20

Similar Documents

Publication Publication Date Title
DE602007012363D1 (de) 2,4-pyridimediamon-derivate als hemmer von jak-kinasen zur behandlung von autoimmunerkrankungen
ATE499097T1 (de) Monozyklische heterozyklen als kinase-hemmer
UA101478C2 (ru) Соединения, полезные как ингибиторы raf-киназы
EA201100580A1 (ru) Имидазопиридазинкарбонитрилы, используемые в качестве ингибиторов киназы
EA200801291A1 (ru) Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ
EA201001359A1 (ru) Гетероциклические соединения в качестве ингибиторов cxcr2
GEP20135785B (en) Pyrrolopyrimidine compounds as cdk inhibitors
EA200970486A1 (ru) Соединения для ингибирования митоза
EA201000093A1 (ru) Производные пиридазинона
EA200970738A1 (ru) Ингибиторы активности akt
NO20074634L (no) Substituerte heterocykler og deres anvendelse som CHK1-, PDK1- og PAK-inhibitorer
EA201000915A1 (ru) Ингибиторы пролилгидроксилазы
JO3007B1 (ar) مركبات و تركيبات كمثبطات كيناز بروتين
EA200600689A1 (ru) Замещённые бензазолы и их применение в качестве ингибиторов raf киназы
EA201100427A1 (ru) Гетероциклические ингибиторы киназы
EA201070247A1 (ru) Ингибиторы протеасом
EA201101341A1 (ru) Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе
EA200701257A1 (ru) Пирролопиразолы в качестве сильнодействующих ингибиторов киназы
EA200870415A1 (ru) Хиназолины для ингибирования pdk 1
EA201291356A1 (ru) Пиперидиноновые производные как ингибиторы mdm2 для лечения рака
EA200970050A1 (ru) Ингибиторы пролилгидроксилаз
EA201390877A1 (ru) Замещенные 6,6-конденсированные азотсодержащие гетероциклические соединения и их применение
EA200900798A1 (ru) Производные индол-4-илпиримидинил-2-иламина и их применение в качестве ингибиторов циклинзависимой киназы
NO20081893L (no) 4-(3-aminopyrazol)pyrimidinderivater til anvendelse som tyrosin-kinaseinhibitorer i behandling av kreft
EA201000100A1 (ru) Гетероциклические соединения, полезные в качестве ингибиторов mk2

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties