ATE395338T1 - Pyrazolderivate, zusammensetzungen, die solche verbindungen enthalten, und anwendungsverfahren - Google Patents

Pyrazolderivate, zusammensetzungen, die solche verbindungen enthalten, und anwendungsverfahren

Info

Publication number: ATE395338T1
Authority: AT; Austria
Prior art keywords: compounds; methods; compositions containing; pyrazole derivatives; pyrazole
Prior art date: 2004-06-04

Application number

AT05754758T

Other languages

English (en)

Inventor

Emma Parmee

Yusheng Xiong

Jian Guo

Rui Liang

Linda Brockunier

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-04

Filing date

2005-05-31

Publication date

2008-05-15

2005-05-31 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2008-05-15 Application granted granted Critical

2008-05-15 Publication of ATE395338T1 publication Critical patent/ATE395338T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Ophthalmology & Optometry (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT05754758T 2004-06-04 2005-05-31 Pyrazolderivate, zusammensetzungen, die solche verbindungen enthalten, und anwendungsverfahren ATE395338T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57711604P	2004-06-04	2004-06-04

Publications (1)

Publication Number	Publication Date
ATE395338T1 true ATE395338T1 (de)	2008-05-15

Family

ID=35335786

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05754758T ATE395338T1 (de)	2004-06-04	2005-05-31	Pyrazolderivate, zusammensetzungen, die solche verbindungen enthalten, und anwendungsverfahren

Country Status (34)

Country	Link
US (2)	US7598285B2 (de)
EP (1)	EP1756064B1 (de)
JP (2)	JP4108739B2 (de)
CN (1)	CN1964947A (de)
AR (2)	AR049291A1 (de)
AT (1)	ATE395338T1 (de)
AU (2)	AU2005252183B2 (de)
BR (1)	BRPI0511703B8 (de)
CA (1)	CA2566945C (de)
CR (1)	CR8766A (de)
CY (1)	CY1108544T1 (de)
DE (1)	DE602005006806D1 (de)
DK (1)	DK1756064T3 (de)
EA (1)	EA012431B1 (de)
EC (1)	ECSP067062A (de)
ES (1)	ES2306165T3 (de)
GE (1)	GEP20094605B (de)
HR (1)	HRP20080311T3 (de)
IL (1)	IL179754A (de)
MA (1)	MA28673B1 (de)
MX (1)	MXPA06014084A (de)
MY (1)	MY143599A (de)
NI (1)	NI200600290A (de)
NO (1)	NO339149B1 (de)
NZ (1)	NZ551405A (de)
PE (1)	PE20060427A1 (de)
PL (1)	PL1756064T3 (de)
PT (1)	PT1756064E (de)
SI (1)	SI1756064T1 (de)
TN (1)	TNSN06397A1 (de)
TW (1)	TWI293952B (de)
UA (1)	UA85884C2 (de)
WO (1)	WO2005121097A2 (de)
ZA (1)	ZA200609489B (de)

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EP1590336B1 (de)	2003-01-27	2010-12-01	Merck Sharp & Dohme Corp.	Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren
GEP20094605B (en)	2004-06-04	2009-02-10	Merck & Co Inc	Pyrazole derivatives, compositions containing such compounds and methods of use thereof
AU2005269792B9 (en) *	2004-07-22	2008-11-27	Merck Sharp & Dohme Corp.	Substituted pyrazoles, compositions containing such compounds and methods of use
US7709658B2 (en)	2005-07-26	2010-05-04	Merck Sharp & Dohme Corp.	Process for synthesizing a substituted pyrazole
AR056574A1 (es) *	2005-10-19	2007-10-10	Merck & Co Inc	Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
WO2008087029A1 (en) *	2007-01-17	2008-07-24	Laboratorios Del Dr. Esteve, S.A.	Substituted pyrazoline compounds with acat inhibition activity
KR20170085615A (ko)	2007-02-09	2017-07-24	메타베이시스 테라퓨틱스, 인크.	글루카곤 수용체의 길항제
EP2170337A4 (de) *	2007-06-28	2013-12-18	Abbvie Inc	Neue triazolopyridazine
US8232413B2 (en) *	2007-09-12	2012-07-31	Merck Sharp & Dohme Corp.	Process for the production of a crystalline glucagon receptor antagonist compound
KR101616140B1 (ko)	2008-03-05	2016-04-27	다케다 야쿠힌 고교 가부시키가이샤	복소환 화합물
WO2009113522A1 (ja)	2008-03-11	2009-09-17	あすか製薬株式会社	固体分散体とその医薬組成物、並びにそれらの製造方法
JP2011520897A (ja)	2008-05-16	2011-07-21	シェーリングコーポレイション	グルカゴン受容体アンタゴニスト、組成物およびそれらの使用方法
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RU2008135294A (ru) *	2008-08-29	2010-03-10	Дик Корпорейшн (Jp)	Нафталиновые производные
WO2010030722A1 (en) *	2008-09-15	2010-03-18	Merck Sharp & Dohme Corp.	Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
AR073412A1 (es) *	2008-10-03	2010-11-03	Schering Corp	Derivados de espiro imidazolona como antagonistas del receptor glucagon y composiciones que los comprende.
WO2010093535A1 (en)	2009-02-12	2010-08-19	Merck Sharp & Dohme Corp.	Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
WO2010098994A1 (en)	2009-02-25	2010-09-02	Merck Sharp & Dohme Corp.	Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use
US8470773B2 (en)	2009-06-12	2013-06-25	Merck Sharp & Dohme Corp.	Thiophenes as glucagon receptor antagonists, compositions, and methods for their use
WO2011037815A1 (en)	2009-09-22	2011-03-31	Schering Corporation	Novel pyrrolidines as glucagon receptor antagonists, compositions, and methods for their use
JP5694561B2 (ja)	2010-12-23	2015-04-01	ファイザー・インク	グルカゴン受容体モジュレーター
WO2012107850A1 (en)	2011-02-08	2012-08-16	Pfizer Inc.	Glucagon receptor modulator
KR20140023441A (ko)	2011-07-22	2014-02-26	화이자 인코포레이티드	퀴놀린일 글루카곤 수용체 조절제
TW201427658A (zh) *	2012-12-10	2014-07-16	Merck Sharp & Dohme	藉由投予升糖素受體拮抗劑及膽固醇吸收抑制劑治療糖尿病之方法
WO2015066252A1 (en)	2013-11-04	2015-05-07	Merck Sharp & Dohme Corp.	Glucagon receptor antagonist compounds, compositions thereof, and methods of use
CN103933032B (zh) *	2013-12-30	2019-08-23	北京赛林泰医药技术有限公司	作为抗癌药物的吡唑类衍生物的使用方法和用途
EP3154956A4 (de)	2014-06-12	2018-01-17	Ligand Pharmaceuticals, Inc.	Glucagonantagonisten
US10995146B2 (en)	2016-08-30	2021-05-04	Regeneron Pharmaceuticals, Inc.	Methods of treating severe insulin resistance by interfering with glucagon receptor signaling
TWI763705B (zh) *	2016-09-06	2022-05-11	比利時商健生藥品公司	可作為升糖素受體拮抗劑之吲哚衍生物
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EP1590336B1 (de) *	2003-01-27	2010-12-01	Merck Sharp & Dohme Corp.	Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren
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GEP20094605B (en)	2004-06-04	2009-02-10	Merck & Co Inc	Pyrazole derivatives, compositions containing such compounds and methods of use thereof
AU2005269792B9 (en) *	2004-07-22	2008-11-27	Merck Sharp & Dohme Corp.	Substituted pyrazoles, compositions containing such compounds and methods of use
AR056574A1 (es) *	2005-10-19	2007-10-10	Merck & Co Inc	Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso

2005
- 2005-05-31 GE GEAP20059788A patent/GEP20094605B/en unknown
- 2005-05-31 HR HR20080311T patent/HRP20080311T3/xx unknown
- 2005-05-31 EP EP05754758A patent/EP1756064B1/de not_active Expired - Lifetime
- 2005-05-31 PL PL05754758T patent/PL1756064T3/pl unknown
- 2005-05-31 AT AT05754758T patent/ATE395338T1/de active
- 2005-05-31 NZ NZ551405A patent/NZ551405A/en not_active IP Right Cessation
- 2005-05-31 WO PCT/US2005/018828 patent/WO2005121097A2/en not_active Ceased
- 2005-05-31 CA CA2566945A patent/CA2566945C/en not_active Expired - Fee Related
- 2005-05-31 JP JP2007515416A patent/JP4108739B2/ja not_active Expired - Fee Related
- 2005-05-31 ES ES05754758T patent/ES2306165T3/es not_active Expired - Lifetime
- 2005-05-31 PT PT05754758T patent/PT1756064E/pt unknown
- 2005-05-31 CN CNA2005800182634A patent/CN1964947A/zh active Pending
- 2005-05-31 BR BRPI0511703A patent/BRPI0511703B8/pt not_active IP Right Cessation
- 2005-05-31 EA EA200602196A patent/EA012431B1/ru not_active IP Right Cessation
- 2005-05-31 UA UAA200700111A patent/UA85884C2/uk unknown
- 2005-05-31 AU AU2005252183A patent/AU2005252183B2/en not_active Ceased
- 2005-05-31 MX MXPA06014084A patent/MXPA06014084A/es active IP Right Grant
- 2005-05-31 DE DE602005006806T patent/DE602005006806D1/de not_active Expired - Lifetime
- 2005-05-31 DK DK05754758T patent/DK1756064T3/da active
- 2005-05-31 MY MYPI20052470A patent/MY143599A/en unknown
- 2005-05-31 SI SI200530296T patent/SI1756064T1/sl unknown
- 2005-06-02 PE PE2005000624A patent/PE20060427A1/es not_active Application Discontinuation
- 2005-06-02 AR ARP050102266A patent/AR049291A1/es active IP Right Grant
- 2005-06-03 US US11/144,332 patent/US7598285B2/en active Active
- 2005-06-03 TW TW094118496A patent/TWI293952B/zh not_active IP Right Cessation
2006
- 2006-11-15 ZA ZA200609489A patent/ZA200609489B/en unknown
- 2006-11-23 CR CR8766A patent/CR8766A/es unknown
- 2006-11-30 IL IL179754A patent/IL179754A/en active IP Right Grant
- 2006-11-30 NI NI200600290A patent/NI200600290A/es unknown
- 2006-12-01 TN TNP2006000397A patent/TNSN06397A1/en unknown
- 2006-12-04 EC EC2006007062A patent/ECSP067062A/es unknown
- 2006-12-20 MA MA29545A patent/MA28673B1/fr unknown
2007
- 2007-01-04 NO NO20070073A patent/NO339149B1/no not_active IP Right Cessation
2008
- 2008-02-05 JP JP2008025035A patent/JP4733153B2/ja not_active Expired - Fee Related
- 2008-07-21 CY CY20081100762T patent/CY1108544T1/el unknown
- 2008-09-30 AU AU2008229701A patent/AU2008229701C1/en not_active Ceased
2009
- 2009-03-17 US US12/405,600 patent/US7799818B2/en not_active Expired - Lifetime
2012
- 2012-11-20 AR ARP120104354A patent/AR088919A2/es unknown

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Publication number	Publication date
PT1756064E (pt)	2008-07-22
HRP20080311T3 (hr)	2008-07-31
CY1108544T1 (el)	2014-04-09
BRPI0511703A (pt)	2008-01-08
TNSN06397A1 (en)	2008-02-22
AU2005252183B2 (en)	2008-07-17
NZ551405A (en)	2009-06-26
ZA200609489B (en)	2007-10-31
MA28673B1 (fr)	2007-06-01
EA200602196A1 (ru)	2007-06-29
TWI293952B (en)	2008-03-01
AU2005252183A1 (en)	2005-12-22
US20090176854A1 (en)	2009-07-09
BRPI0511703B8 (pt)	2021-05-25
CN1964947A (zh)	2007-05-16
IL179754A (en)	2013-12-31
EP1756064B1 (de)	2008-05-14
JP4108739B2 (ja)	2008-06-25
NO20070073L (no)	2007-03-05
US7799818B2 (en)	2010-09-21
AU2008229701C1 (en)	2010-07-29
DE602005006806D1 (de)	2008-06-26
WO2005121097A3 (en)	2006-02-16
IL179754A0 (en)	2007-05-15
ECSP067062A (es)	2007-01-26
SI1756064T1 (sl)	2008-12-31
CR8766A (es)	2007-08-28
MY143599A (en)	2011-06-15
CA2566945A1 (en)	2005-12-22
AR049291A1 (es)	2006-07-12
PE20060427A1 (es)	2006-06-19
AU2008229701B2 (en)	2010-03-04
EP1756064A2 (de)	2007-02-28
DK1756064T3 (da)	2008-09-22
PL1756064T3 (pl)	2008-11-28
NO339149B1 (no)	2016-11-14
MXPA06014084A (es)	2007-02-15
WO2005121097A2 (en)	2005-12-22
EA012431B1 (ru)	2009-10-30
BRPI0511703B1 (pt)	2018-07-17
NI200600290A (es)	2007-08-07
JP2008150388A (ja)	2008-07-03
JP4733153B2 (ja)	2011-07-27
CA2566945C (en)	2010-09-21
AR088919A2 (es)	2014-07-16
ES2306165T3 (es)	2008-11-01
US20050272794A1 (en)	2005-12-08
US7598285B2 (en)	2009-10-06
UA85884C2 (uk)	2009-03-10
GEP20094605B (en)	2009-02-10
TW200604179A (en)	2006-02-01
JP2008505062A (ja)	2008-02-21
AU2008229701A1 (en)	2008-10-30

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