ATE374777T1 - Analoga als antitumorale verbindungen - Google Patents

Analoga als antitumorale verbindungen

Info

Publication number: ATE374777T1
Authority: AT; Austria
Prior art keywords: analogue; antitumoral compounds; antitumoral; compounds; ecteinascidin
Prior art date: 2001-08-07

Application number

AT02753134T

Other languages

English (en)

Inventor

Valentin Martinez

Pilar Gallego

Carmen Cuevas

Simon Munt

Ignacio Manzanares

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-07

Filing date

2002-08-06

Publication date

2007-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9919954&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE374777(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-08-06 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE374777T1 publication Critical patent/ATE374777T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Saccharide Compounds (AREA)
Peptides Or Proteins (AREA)
Compounds Of Unknown Constitution (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT02753134T 2001-08-07 2002-08-06 Analoga als antitumorale verbindungen ATE374777T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0119243.4A GB0119243D0 (en)	2001-08-07	2001-08-07	Antitumoral analogs of ET-743

Publications (1)

Publication Number	Publication Date
ATE374777T1 true ATE374777T1 (de)	2007-10-15

Family

ID=9919954

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02753134T ATE374777T1 (de)	2001-08-07	2002-08-06	Analoga als antitumorale verbindungen

Country Status (22)

Country	Link
US (1)	US7763615B2 (de)
EP (3)	EP1414828B9 (de)
JP (2)	JP4684552B2 (de)
KR (1)	KR20040032150A (de)
CN (1)	CN100334094C (de)
AT (1)	ATE374777T1 (de)
AU (1)	AU2002313540B2 (de)
CA (1)	CA2455768C (de)
CY (1)	CY1107830T1 (de)
DE (1)	DE60222775T2 (de)
DK (1)	DK1414828T3 (de)
ES (1)	ES2294151T3 (de)
GB (1)	GB0119243D0 (de)
HU (1)	HU229779B1 (de)
IL (2)	IL160051A0 (de)
MX (1)	MXPA04001240A (de)
NO (1)	NO337476B1 (de)
NZ (1)	NZ530837A (de)
PL (1)	PL218295B1 (de)
PT (1)	PT1414828E (de)
RU (1)	RU2283842C2 (de)
WO (1)	WO2003014127A1 (de)

Families Citing this family (34)

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GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
KR101614723B1 (ko)	2008-01-11	2016-04-22	알바니 몰레큘라 리써치, 인크.	Ｍｃｈ 길항물질로서 (1-아지논)-치환된 피리도인돌
US8629158B2 (en) *	2009-07-01	2014-01-14	Albany Molecular Research, Inc.	Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) *	2009-07-01	2013-12-31	Albany Molecular Research, Inc.	Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
WO2011003021A1 (en) *	2009-07-01	2011-01-06	Albany Molecular Research, Inc.	Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof
JP2012532144A (ja) *	2009-07-01	2012-12-13	アルバニーモレキュラーリサーチ，インコーポレイテッド	アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
ES2534331T3 (es) *	2010-05-25	2015-04-21	Pharma Mar S.A.	Proceso sintético para la producción de compuestos e intermedios de ecteinascidina
HUE042801T2 (hu) *	2010-11-12	2019-07-29	Pharma Mar Sa	Kombinációs terápia mitózisgátlóval
CN105611297B (zh)	2010-11-26	2018-09-07	日本电气株式会社	视频解码设备、视频解码方法
US8697700B2 (en)	2010-12-21	2014-04-15	Albany Molecular Research, Inc.	Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof
US8993765B2 (en)	2010-12-21	2015-03-31	Albany Molecular Research, Inc.	Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2017067670A1 (en)	2015-10-23	2017-04-27	Pharmathen S.A.	A novel process for the preparation of tryptamines and derivatives thereof
JOP20190254A1 (ar) *	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
TWI824043B (zh) *	2018-10-25	2023-12-01	西班牙商瑪製藥股份有限公司	藥物抗體共軛物
EP4025217A1 (de)	2019-09-03	2022-07-13	Pharma Mar, S.A.	Lurbinectedin zur behandlung von malignem mesotheliom
CN112574234B (zh) *	2019-09-27	2022-05-24	江苏恒瑞医药股份有限公司	一种海鞘素衍生物的制备方法
MA56827B2 (fr) *	2019-11-21	2023-09-27	Pharma Mar Sa	Procédés de traitement du cancer du poumon à petites cellules avec des formulations de lurbinectédine
WO2021228414A1 (en)	2020-05-14	2021-11-18	Pharma Mar, S.A.	Methods of treating small cell lung cancer with lurbinectedin formulations
PH12022551216A1 (en)	2019-11-21	2023-07-17	Pharma Mar Sa	Methods of treating small cell lung cancer with lurbinectedin formulations
JP2023522259A (ja)	2020-04-21	2023-05-29	ファルマ、マール、ソシエダード、アノニマ	薬物抗体コンジュゲート
TW202144369A (zh) *	2020-04-26	2021-12-01	大陸商江蘇恆瑞醫藥股份有限公司	海鞘素類衍生物及其製備方法與醫藥用途
JP2023541010A (ja)	2020-09-04	2023-09-27	ファルマ、マール、ソシエダード、アノニマ	ルルビネクテジンと免疫チェックポイント阻害剤との組合せ
WO2022101255A1 (en)	2020-11-10	2022-05-19	Pharma Mar, S.A.	Lurbinectedin and irinotecan combinations
IN202141039393A (de) *	2021-08-31	2023-03-03
IL312263A (en)	2021-11-08	2024-06-01	Pharma Mar Sa	Lurbinectedin and atezolizumab combinations
CN115246846B (zh) *	2021-11-19	2024-10-01	江苏慧聚药业股份有限公司	卢比替定新晶型及其制备
CN118388507A (zh) *	2022-04-08	2024-07-26	上海皓元医药股份有限公司	一种卢比替定的晶型及其制备方法
CN114940682A (zh) *	2022-05-18	2022-08-26	博瑞制药(苏州)有限公司	芦比替定的晶型及其制备方法和用途
WO2024186263A1 (en) *	2023-03-07	2024-09-12	Axcynsis Therapeutics Pte. Ltd.	Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
WO2024188978A1 (en)	2023-03-10	2024-09-19	Pharma Mar, S.A.	Lurbinectedin as mcl-1 inhibitor and combinations thereof for use in treating cancer
WO2025059336A1 (en) *	2023-09-13	2025-03-20	Navinta, Llc	An improved process for preparation of lurbinectedin
WO2025077996A1 (en)	2023-10-09	2025-04-17	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds
EP4563149A1 (de)	2023-11-30	2025-06-04	Pharma Mar, S.A.	Lurbinectedin, ecubectedin und eine verwandte verbindung zur verwendung bei der behandlung von hautkrebs
TW202532075A (zh) *	2024-02-08	2025-08-16	大陸商映恩生物製藥（蘇州）有限公司	海鞘素類化合物及其應用

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JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
JPS6084288A (ja)	1983-10-13	1985-05-13	Shionogi & Co Ltd	シアノキノナミンアセテ−ト類およびその製造法
US5149804A (en) *	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
US5256663A (en)	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en)	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
AU589282B2 (en)	1986-06-09	1989-10-05	University Of Illinois	Ecteinascidins 729, 743, 745, 759a, 759b and 770
US5478932A (en) *	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US5721362A (en)	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en) *	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
DE69936845T2 (de) *	1998-04-06	2008-05-08	The Board Of Trustees Of The University Of Illinois, Urbana	Halbsynthetische ectein-ascidine
EP1077698B1 (de) *	1998-05-11	2005-03-02	Pharma Mar, S.A.	Ecteinascidinderivate
US6124292A (en)	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
AR035842A1 (es)	1999-05-14	2004-07-21	Pharma Mar Sa	Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
EP1254140A4 (de) *	2000-01-19	2003-03-12	Univ Columbia	Verbindungen der saframycin-ecteinascidin-serie, verwendungen und synthesen davon
ATE299146T1 (de)	2000-04-12	2005-07-15	Pharma Mar Sa	Ecteinaschidin derivate mit antikrebs wirkung
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.

2001
- 2001-08-07 GB GBGB0119243.4A patent/GB0119243D0/en not_active Ceased
2002
- 2002-08-06 US US10/485,536 patent/US7763615B2/en not_active Expired - Lifetime
- 2002-08-06 CA CA2455768A patent/CA2455768C/en not_active Expired - Lifetime
- 2002-08-06 ES ES02753134T patent/ES2294151T3/es not_active Expired - Lifetime
- 2002-08-06 PT PT02753134T patent/PT1414828E/pt unknown
- 2002-08-06 PL PL367940A patent/PL218295B1/pl unknown
- 2002-08-06 JP JP2003519076A patent/JP4684552B2/ja not_active Expired - Lifetime
- 2002-08-06 AU AU2002313540A patent/AU2002313540B2/en active Active
- 2002-08-06 RU RU2004106617/04A patent/RU2283842C2/ru active
- 2002-08-06 IL IL16005102A patent/IL160051A0/xx unknown
- 2002-08-06 MX MXPA04001240A patent/MXPA04001240A/es active IP Right Grant
- 2002-08-06 AT AT02753134T patent/ATE374777T1/de active
- 2002-08-06 DK DK02753134T patent/DK1414828T3/da active
- 2002-08-06 CN CNB028196511A patent/CN100334094C/zh not_active Expired - Lifetime
- 2002-08-06 KR KR10-2004-7001924A patent/KR20040032150A/ko not_active Ceased
- 2002-08-06 EP EP02753134A patent/EP1414828B9/de not_active Expired - Lifetime
- 2002-08-06 EP EP07001308A patent/EP1806349A1/de not_active Ceased
- 2002-08-06 NZ NZ530837A patent/NZ530837A/en not_active IP Right Cessation
- 2002-08-06 EP EP10180740A patent/EP2270018A1/de not_active Withdrawn
- 2002-08-06 HU HU0401174A patent/HU229779B1/hu unknown
- 2002-08-06 DE DE60222775T patent/DE60222775T2/de not_active Expired - Lifetime
- 2002-08-06 WO PCT/GB2002/003592 patent/WO2003014127A1/en not_active Ceased
2004
- 2004-01-26 IL IL160051A patent/IL160051A/en active IP Right Grant
- 2004-03-05 NO NO20040961A patent/NO337476B1/no not_active IP Right Cessation
2007
- 2007-12-12 CY CY20071101576T patent/CY1107830T1/el unknown
2010
- 2010-09-17 JP JP2010209928A patent/JP2011026331A/ja active Pending

Also Published As

Publication number	Publication date
EP2270018A1 (de)	2011-01-05
DE60222775D1 (de)	2007-11-15
US7763615B2 (en)	2010-07-27
CN100334094C (zh)	2007-08-29
RU2004106617A (ru)	2005-04-10
JP2011026331A (ja)	2011-02-10
IL160051A0 (en)	2004-06-20
CN1564822A (zh)	2005-01-12
HU229779B1 (en)	2014-07-28
HUP0401174A2 (hu)	2005-09-28
EP1806349A1 (de)	2007-07-11
HUP0401174A3 (en)	2005-12-28
DE60222775T2 (de)	2008-07-17
CY1107830T1 (el)	2013-06-19
EP1414828A1 (de)	2004-05-06
CA2455768A1 (en)	2003-02-20
WO2003014127A1 (en)	2003-02-20
PL367940A1 (en)	2005-03-07
NO337476B1 (no)	2016-04-18
EP1414828B1 (de)	2007-10-03
KR20040032150A (ko)	2004-04-14
MXPA04001240A (es)	2004-06-03
RU2283842C2 (ru)	2006-09-20
AU2002313540B2 (en)	2008-05-22
IL160051A (en)	2012-01-31
PL218295B1 (pl)	2014-11-28
DK1414828T3 (da)	2008-02-04
PT1414828E (pt)	2007-12-27
EP1414828B9 (de)	2008-02-20
GB0119243D0 (en)	2001-10-03
NZ530837A (en)	2005-07-29
ES2294151T3 (es)	2008-04-01
CA2455768C (en)	2011-10-11
US20060128711A1 (en)	2006-06-15
HK1065786A1 (en)	2005-03-04
JP4684552B2 (ja)	2011-05-18
JP2005501093A (ja)	2005-01-13
NO20040961L (no)	2004-03-05

Publication	Publication Date	Title
ATE374777T1 (de)	2007-10-15	Analoga als antitumorale verbindungen
NO943002L (no)	1995-02-20	Fosfono-oksymetyletere av taxanderivater
DE60234690D1 (de)	2010-01-21	Neue verbindungen als entzündungshemmende, immunmodulierende und antiproliferative mittel
ATE219938T1 (de)	2002-07-15	Neue 4-arylpiperazine und 4-arylpiperidine
NO20021358D0 (no)	2002-03-19	Alkylendiamin-substituerte heterocykler
DE60030741D1 (de)	2006-10-26	Chinazoline verbindungen als heilmittel
ECSP044997A (es)	2004-04-28	DERIVADOS SUSTITUIDOS DEL INDENO [1,2-c] ISOQUINOLINA
DK0582788T3 (da)	1999-02-01	7-(Substituerede)-9-[(substitueret glycyl)-amido]-demethyl-6-deoxytetracycliner
DE60229736D1 (de)	2008-12-18	Spiroinden- und spiroindan-verbindungen
DK1273299T3 (da)	2006-02-06	Minoxidilinindeholdende praparater
ATE246196T1 (de)	2003-08-15	Sulphostinanaloga und verfahren zur herstellung von sulphostin und analoga davon
BRPI0409376A (pt)	2006-04-25	derivados de indeno como agentes farmacêuticos
DE69708968D1 (de)	2002-01-24	Arylacrylamidderivate als 5HT1 Agoniste oder Antagoniste
MX9702259A (es)	1997-06-28	Derivados de quinoxalina utiles en terapia.
ATE422531T1 (de)	2009-02-15	Organische verbindungen
ATE469902T1 (de)	2010-06-15	Amorphe substanz eines tricyclischen triazolobenzazepinderivats
ATE227713T1 (de)	2002-11-15	1,2-substituierte 2,3-dihydro-1h-5,9- dioxacyclohepta(f)inden-7-one und 7-substituierte benzo(b)(1,4)dioxepin-3-one
DK1085019T3 (da)	2003-05-26	Omoprazolsyntese
DK0878195T3 (da)	2002-07-15	Anvendelse af en 2-aroyl-3-arylbenzo(b)thiophenforbindelse til reduktion af fibrinogenniveauerne
ATE478155T1 (de)	2010-09-15	Glycopeptidantibiotika
DE69434010D1 (de)	2004-10-21	C7-Taxan-Derivate und diese enthaltende pharmazeutische Zusammenstellungen
AR035699A1 (es)	2004-06-23	Asociacion de al menos un derivado de piridoindolona, composicion farmaceutica que comprende al menos un derivado de piridoindolona y kit para el tratamiento de la proliferacion de celulas tumorales
ECSP972237A (es)	1998-09-22	Derivados de 6,5 heterobiciclicos sustituidos
DE69333895D1 (de)	2005-12-01	Pharmazeutische Zusammensetzungen enthaltend neue iso-Butenyl-substituierte Taxane

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